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Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
Vanessa Bellini Bardella, Sebastián Pita, André Luis Laforga Vanzela, Cleber Galvão, Francisco Panzera
The subfamily Triatominae (Hemiptera, Reduviidae) includes 150 species of blood-sucking insects, vectors of Chagas disease or American trypanosomiasis. Karyotypic information reveals a striking stability in the number of autosomes. However, this group shows substantial variability in genome size, the amount and distribution of C-heterochromatin, and the chromosome positions of 45S rDNA clusters. Here, we analysed the karyotypes of 41 species from six different genera with C-fluorescence banding in order to evaluate the base-pair richness of heterochromatic regions...
October 2016: Memórias do Instituto Oswaldo Cruz
Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Paul Willner
Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in clinical studies to be effective in treatment-resistant patients, with an effect that appears within hours and lasts for a few days. Chronic mild stress (CMS) is a well-established and widely used animal model of depression, in which anhedonia, anxiogenesis and cognitive dysfunction can be observed reliably. Studies using acute or brief ketamine treatment following withdrawal from CMS have replicated the clinical finding of a rapid onset of antidepressant action...
October 18, 2016: Behavioural Pharmacology
Y Krylova, V Polyakova, I Kvetnoy, I Kogan, L Dzhemlikhanova, D Niauri, A Gzgzyan, E Ailamazyan
: Abstracts Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. MATERIALS AND METHODS: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015...
October 2016: Gynecological Endocrinology
R T Pivik, Aline Andres, Shasha Bai, Mario A Cleves, Kevin B Tennal, Yuyuan Gu, Thomas M Badger
Since maturational processes triggering increased attunement to native language features in early infancy are sensitive to dietary factors, infant-diet related differences in brain processing of native-language speech stimuli might indicate variations in the onset of this tuning process. We measured cortical responses (ERPs) to syllables in 4 and 5 month old infants fed breast milk, milk formula, or soy formula and found syllable discrimination (P350) and syntactic-related functions (P600) but not syllable perception (P170) varied by diet, but not gender or background measures...
October 19, 2016: Developmental Neuropsychology
Ashley Galati, Alyson Hock, Ramesh S Bhatt
Configural information (spacing between features) contributes to face-processing expertise in adulthood. We examined whether infants can be "trained" to process this information. In Experiment 1, 3.5-month-olds failed to discriminate changes in the spacing between facial features. However, in Experiments 2 and 3, infants processed the same information after being primed with faces in which the spacing was repeatedly altered. Experiment 4 found that priming was not effective with inverted faces or with faces depicting changes in features but not relations among features, indicating that the priming exhibited in Experiments 2 and 3 was specific to upright faces depicting spacing changes...
November 2016: Developmental Psychobiology
Eric S Orwoll, Jodi Lapidus, Patty Y Wang, Liesbeth Vandenput, Andrew Hoffman, Howard Fink, Gail A Laughlin, Maria Nethander, Östen Ljunggren, Andreas Kindmark, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Anthony Kwok, Sundeep Khosla, Timothy Kwok, Claes Ohlsson
Measurement of serum testosterone (T) levels is recommended in the evaluation of osteoporosis in older men and estradiol (E2) and sex hormone binding globulin (SHBG) levels are associated with the rate of bone loss and fractures, but the clinical utility of sex steroid and SHBG measurements for the evaluation of osteoporosis in men has not been examined. To evaluate whether measurements of T, E2 and/or SHBG are useful for the prediction of fracture risk or the rate of bone loss in older men, we analyzed longitudinal data from 5487 community-based men participating in the MrOS Study in the US, Sweden and Hong Kong...
October 18, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jessica Shaw, Rebecca Campbell, Debi Cain
Prior research has documented the problematic community response to sexual assault: the majority of sexual assaults reported to police are never prosecuted. Social dominance theory suggests that this response is a form of institutional discrimination, intended to maintain existing social structures, and that police personnel likely draw upon shared ideologies to justify their decision-making in sexual assault case investigations. This study drew upon social dominance theory to examine how police justified their investigatory decisions to identify potential leverage points for change...
October 18, 2016: American Journal of Community Psychology
Pamela L Geller, Christopher M Stojanowksi
OBJECTIVES: This article uses craniometric allocation as a platform for discussing the legacy of Samuel G. Morton's collection of crania, the process of racialization, and the value of contextualized biohistoric research perspectives in biological anthropology. MATERIALS AND METHODS: Standard craniometric measurements were recorded for seven Seminoles in the Samuel G. Morton Crania Collection and 10 European soldiers from the Fort St. Marks Military Cemetery; all individuals were men and died in Florida during the 19th century...
October 18, 2016: American Journal of Physical Anthropology
Bernd Schmidt, Grit Rehbein, Michael Fleischhacker
Extracellular miRNAs cannot only be isolated from different body fluids like plasma and serum, but also from bronchial lavage samples (BL) obtained by bronchoscopy. Alterations in the expression of microRNAs might be useful for a discrimination of lung cancer patients from patients with a benign lung disease. We profiled extracellular microRNAs from three BL pools of lung cancer patients and three BL pools from a control group (patients with a benign lung disease) with TaqMan MicroRNA Array cards. For the confirmation of these results, we analyzed a panel of eight miRNAs in a qRT-PCR of the BL of 30 different lung cancer and non-cancerous patients...
2016: Advances in Experimental Medicine and Biology
Ivan D Osipov, Ivan A Zaporozhchenko, Anna A Bondar, Marat M Zaripov, Vladimir E Voytsitskiy, Valentin V Vlassov, Pavel P Laktionov, Evgeny S Morozkin
Expression levels of five miRNAs (miR-19b, miR-21, miR-126, miR-141, miR-205) were measured in the plasma of healthy donors and prostate cancer patients. It was shown that miR-141 expression level efficiently discriminates early stage prostate cancer patients and correlates with the Gleason score.
2016: Advances in Experimental Medicine and Biology
Jenny L Wiley, Julie A Marusich, Brian F Thomas
Originally developed as research tools for use in structure-activity relationship studies, synthetic cannabinoids contributed to significant scientific advances in the cannabinoid field. Unfortunately, a subset of these compounds was diverted for recreational use beginning in the early 2000s. As these compounds were banned, they were replaced with additional synthetic cannabinoids with increasingly diverse chemical structures. This chapter focuses on integration of recent results with those covered in previous reviews...
October 18, 2016: Current Topics in Behavioral Neurosciences
Richard W Handel
The Minnesota Multiphasic Personality Inventory-Adolescent-Restructured Form (MMPI-A-RF; Archer, Handel, Ben-Porath, & Tellegen, 2016) is a new broadband measure of adolescent psychopathology and personality. The MMPI-A-RF is the adolescent counterpart of the MMPI-2-RF (Ben-Porath & Tellegen, 2008/2011). The goal of the MMPI-2-RF development project was to capture the clinically significant substance of the MMPI-2 item pool with a psychometrically sound measure linked to contemporary models of personality and psychopathology (Ben-Porath & Tellegen, 2008/2011)...
October 17, 2016: Journal of Clinical Psychology in Medical Settings
Anees A Ansari, Abdul K Parchur, Brijesh Kumar, S B Rai
The design of nanostructured materials with highly stable water-dispersion and luminescence efficiency is an important concern in nanotechnology and nanomedicine. In this paper, we described the synthesis and distinct surface modification on the morphological structure and optical (optical absorption, band gap energy, excitation, emission, decay time, etc.) properties of highly crystalline water-dispersible CaF2:Ce/Tb nanocrystals (core-nanocrystals). The epitaxial growth of inert CaF2 and silica shell, respectively, on their surface forming as CaF2:Ce/Tb@CaF2 (core/shell) and CaF2:Ce/Tb@CaF2@SiO2 (core/shell/SiO2) nanoarchitecture...
December 2016: Journal of Materials Science. Materials in Medicine
Ibrahim Ali Kabbash, Ehab A Abo Ali, Mostafa Mahmoud Elgendy, Mostafa Mohamed Abdrabo, Helal Mohamed Salem, Mohammed Ramadan Gouda, Yousef Saleh Elbasiony, Nader Elboshy, Mohammed Hamed
HIV/AIDS-related stigma and discrimination among health care professionals is one of the most important factors of this disease expansion. This study aimed to assess the stigmatized attitude among health care providers toward people living with HIV (PLHIV) at Tanta University Hospitals. The study is a cross-sectional survey. Data was gathered from randomly selected 310 health care workers at Tanta University Hospital using a structured questionnaire. Among studied participants, only 24.0 % had previous contact with HIV patients during work and 21...
October 18, 2016: Environmental Science and Pollution Research International
Will Kew, Ian Goodall, David Clarke, Dušan Uhrín
Scotch Whisky is an important product, both culturally and economically. Chemically, Scotch Whisky is a complex mixture, which comprises thousands of compounds, the nature of which are largely unknown. Here, we present a thorough overview of the chemistry of Scotch Whisky as observed by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Eighty-five whiskies, representing the majority of Scotch Whisky produced and sold, were analyzed by untargeted high-resolution mass spectrometry. Thousands of chemical formulae were assigned for each sample based on parts-per-billion mass accuracy of FT-ICR MS spectra...
October 17, 2016: Journal of the American Society for Mass Spectrometry
Divya Balaji, Linda B Mlunde, Olivia C Tran, Barrot Lambdin, Jessie Mbwambo, Cassian Nyandindi, Eva Matiko, Michael Copenhaver, R Douglas Bruce
High prevalence of human immunodeficiency virus (HIV) among females who use drugs in Dar es Salaam, Tanzania, contrasts strikingly with their low enrollment in HIV risk reduction services such as methadone assisted therapy (MAT). We conducted a case-control study to examine factors associated with non-enrollment in MAT, with a focus on gender-based violence. We interviewed 202 female heroin users not enrolled in MAT as cases and 93 females enrolled in MAT. We fitted logistic regression models with MAT enrollment as the outcome of interest...
October 17, 2016: AIDS and Behavior
Christina Dyar, Brian A Feinstein, Nicholas R Eaton, Bonita London
The negative impact of discrimination on mental health among lesbian, gay, and bisexual populations has been well documented. However, the possible mediating roles of sexual orientation rejection sensitivity and rejection-based proximal stress in the association between discrimination and internalizing symptoms remain unclear. Rejection-based proximal stress is a subset of proximal stressors that are theorized to arise from concerns about and expectations of sexual orientation-based rejection and discrimination...
October 17, 2016: Archives of Sexual Behavior
Samuel Beaulieu, Antoine Comby, Baptiste Fabre, Dominique Descamps, Amélie Ferré, Gustavo Garcia, Romain Géneaux, Francois Légaré, Laurent Nahon, Stéphane Petit, Thierry Ruchon, Bernard Pons, Valérie Blanchet, Yann Mairesse
Measuring the ultrafast dynamics of chiral molecules in the gas phase has been a long standing and challenging quest of molecular physics. The main limitation to reach that goal has been the lack of highly sensitive chiroptical measurement. By enabling chiral discrimination with up to several 10% of sensitivity, photoelectron circular dichroism (PECD) offers a solution to this issue. However, tracking ultrafast processes requires measuring PECD with ultrashort light pulses. Here we compare the PECD obtained with different light sources, from the extreme ultraviolet to the mid-infrared range, leading to different ionization regimes: single-photon, resonance-enhanced multiphoton, above-threshold and tunnel ionization...
October 18, 2016: Faraday Discussions
Mike Horton, Amanda E Perry
Aims and method To explore the modern psychometric properties of the Patient Health Questionnaire (PHQ-9), we used the Rasch analysis in a sample of 767 primary care patients with depression. Results The analysis highlighted dependency issues between items 1 and 2 ('Little interest or pleasure in doing things' and 'Feeling down, depressed, or hopeless'), and items 3 and 4 ('Trouble falling or staying asleep, or sleeping too much' and 'Feeling tired or having little energy'). Items 1 and 2 displayed an over-discrimination, suggesting their potential redundancy within the complete item set...
October 2016: BJPsych Bulletin
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