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https://www.readbyqxmd.com/read/27911467/a-systematic-investigation-of-the-charging-effect-in-scanning-electron-microscopy-for-metal-nanostructures-on-insulating-substrates
#1
R Flatabø, A Coste, M M Greve
Scanning electron microscopy is perhaps the most important method for investigating and characterizing nanostructures. A well-known challenge in scanning electron microscopy is the investigation of insulating materials. As insulating materials do not provide a path to ground they accumulate charge, evident as image drift and image distortions. In previous work, we have seen that sample charging in arrays of metal nanoparticles on glass substrates leads to a shrinkage effect, resulting in a measurement error in the nanoparticle dimension of up to 15% at 10 kV and a probe current of 80 ± 10 pA...
December 2, 2016: Journal of Microscopy
https://www.readbyqxmd.com/read/27911261/targeted-deletion-of-akap7-in-dentate-granule-cells-impairs-spatial-discrimination
#2
Brian W Jones, Jennifer Deem, Thomas J Younts, Michael Weisenhaus, Christina A Sanford, Margaret C Slack, Jenesa Chin, Daniela Nachmanson, Alex McKennon, Pablo E Castillo, G Stanley McKnight
Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals...
December 2, 2016: ELife
https://www.readbyqxmd.com/read/27910923/protein-expression-from-unintegrated-hiv-1-dna-introduces-bias-in-primary-in-vitro-post-integration-latency-models
#3
Pawel Bonczkowski, Marie-Angélique De Scheerder, Eva Malatinkova, Alexandra Borch, Zora Melkova, Renate Koenig, Ward De Spiegelaere, Linos Vandekerckhove
To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed. In an attempt to mimic the in vivo situation as closely as possible, several models use primary cells and replication-competent viruses in combination with antiretroviral compounds to prevent ongoing replication. Latency is subsequently measured by HIV RNA and/or protein production after cellular activation. To discriminate between pre- and post-integration latency, integrase inhibitors are routinely used, preventing novel integrations upon cellular activation...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910906/analysis-of-the-serum-lipid-profile-in-polypoidal-choroidal-vasculopathy
#4
Miaoling Li, Xiongze Zhang, Nanying Liao, Baikang Ye, Yuting Peng, Yuying Ji, Feng Wen
Polypoidal choroidal vasculopathy (PCV), the predominant subtype of neovascular age-related macular degeneration in the Asian population, is associated with genetic polymorphism of lipid metabolism. In this study, we performed the untargeted lipidomics approach of ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) to reveal the potential discriminating lipid profile of PCV patients in serum (21 PCV patients and 19 age-matched controls). Unsupervised principal component, supervised orthogonal partial least squares analysis, correlation analysis, and heatmap analysis were performed with the data obtained by UPLC-MS...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910903/prostate-cancer-patients-negative-biopsy-controls-discrimination-by-untargeted-metabolomics-analysis-of-urine-by-lc-qtof-upstream-information-on-other-omics
#5
M A Fernández-Peralbo, E Gómez-Gómez, M Calderón-Santiago, J Carrasco-Valiente, J Ruiz-García, M J Requena-Tapia, M D Luque de Castro, F Priego-Capote
The existing clinical biomarkers for prostate cancer (PCa) diagnosis are far from ideal (e.g., the prostate specific antigen (PSA) serum level suffers from lack of specificity, providing frequent false positives leading to over-diagnosis). A key step in the search for minimum invasive tests to complement or replace PSA should be supported on the changes experienced by the biochemical pathways in PCa patients as compared to negative biopsy control individuals. In this research a comprehensive global analysis by LC-QTOF was applied to urine from 62 patients with a clinically significant PCa and 42 healthy individuals, both groups confirmed by biopsy...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910869/multiparameter-mechanical-and-morphometric-screening-of-cells
#6
Mahdokht Masaeli, Dewal Gupta, Sean O'Byrne, Henry T K Tse, Daniel R Gossett, Peter Tseng, Andrew S Utada, Hea-Jin Jung, Stephen Young, Amander T Clark, Dino Di Carlo
We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply machine-learning approaches to discriminate different cell types and states. When employing the full 15 dimensional dataset, the technique robustly classifies individual cells based on their pluripotency, with accuracy above 95%. Rheological and morphological properties of cells while deforming were critical for this classification...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#7
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27910790/exploring-geographical-differentiation-of-the-hoelen-medicinal-mushroom-wolfiporia-extensa-agaricomycetes-using-fourier-transform-infrared-spectroscopy-combined-with-multivariate-analysis
#8
Yan Li, Ji Zhang, Yanli Zhao, Honggao Liu, Yuanzhong Wang, Hang Jin
In this study the geographical differentiation of dried sclerotia of the medicinal mushroom Wolfiporia extensa, obtained from different regions in Yunnan Province, China, was explored using Fourier-transform infrared (FT-IR) spectroscopy coupled with multivariate data analysis. The FT-IR spectra of 97 samples were obtained for wave numbers ranging from 4000 to 400 cm-1. Then, the fingerprint region of 1800-600 cm-1 of the FT-IR spectrum, rather than the full spectrum, was analyzed. Different pretreatments were applied on the spectra, and a discriminant analysis model based on the Mahalanobis distance was developed to select an optimal pretreatment combination...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910788/metabolomic-investigation-of-rat-serum-following-oral-administration-of-the-willow-bracket-medicinal-mushroom-phellinus-igniarius-agaricomycetes-by-uplc-hdms
#9
Yu Dong, Ying He, Zhongming Yu, Yang Zhang, Nani Wang, Dan Shou, Changyu Li
The medicinal willow bracket mushroom, Phellinus igniarius, is a species that has been reported to possess antibacterial, antioxidative, antitumor, antidiabetic, and antihyperlipidemia activities. The aim of this study was to elucidate the changes in endogenous metabolites after oral administration of a decoction of Ph. Igniarius. Ultraperformance liquid chromatography (UPLC)/electrospray ionization synapt high-definition mass spectrometry (ESI-HDMS) combined with pattern recognition approaches, including principal component analysis and orthogonal partial least squares discriminant analysis, were integrated to discover differentiating metabolites...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910762/genetic-diversity-and-relationships-of-24-strains-of-genus-auricularia-agaricomycetes-assessed-using-srap-markers
#10
Ping Du, Tian-Xu Cao, Bao-Kai Cui, Yuan Yuan, Yu-Cheng Dai
Auricularia species are well known for their traditional edible and medicinal importance. In this study, sequence-related amplified polymorphism (SRAP) markers were used to evaluate the genetic diversity and relationships of 24 Auricularia strains obtained from different ecological regions of China. A total of 402 polymorphic loci were detected using 11 SRAP primer combinations with 100% polymorphic loci. The similarity coefficient ranged from 0.662 to 0.903, with an average of 0.73. Cluster analysis using the pair-group method using arithmetic average, based on the data from SRAP loci amplified by 11 primer pairs, showed that 24 Auricularia strains were distinguished into 4 groups with 73% similarity...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910678/first-results-from-the-thomson-scattering-diagnostic-on-proto-mpex
#11
T M Biewer, S Meitner, J Rapp, H Ray, G Shaw
A Thomson scattering (TS) diagnostic has been successfully implemented on the prototype Material Plasma Exposure eXperiment (Proto-MPEX) at Oak Ridge National Laboratory. The diagnostic collects the light scattered by plasma electrons and spectroscopically resolves the Doppler shift imparted to the light by the velocity of the electrons. The spread in velocities is proportional to the electron temperature, while the total number of photons is proportional to the electron density. TS is a technique used on many devices to measure the electron temperature (Te) and electron density (ne) of the plasma...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910492/development-towards-a-fast-ion-loss-detector-for-the-reversed-field-pinch
#12
P J Bonofiglo, J K Anderson, A F Almagri, J Kim, J Clark, W Capecchi, S H Sears, J Egedal
A fast ion loss detector has been constructed and implemented on the Madison Symmetric Torus (MST) to investigate energetic ion losses and transport due to energetic particle and MHD instabilities. The detector discriminates particle orbits solely on pitch and consists of two thin-foil, particle collecting plates that are symmetric with respect to the device aperture. One plate collects fast ion signal, while the second aids in the minimization of background and noise effects. Initial measurements are reported along with suggestions for the next design phase of the detector...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910457/applying-the-new-gamma-ray-imager-diagnostic-to-measurements-of-runaway-electron-bremsstrahlung-radiation-in-the-diii-d-tokamak-invited
#13
C M Cooper, D C Pace, C Paz-Soldan, N Commaux, N W Eidietis, E M Hollmann, D Shiraki
A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909988/predicting-the-abuse-liability-of-entactogen-class-new-and-emerging-psychoactive-substances-via-preclinical-models-of-drug-self-administration
#14
Shawn M Aarde, Michael A Taffe
Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as cocaine and methamphetamine. Members of the entactogen class of psychostimulants (drugs that produce an "open mind state" including feelings of interpersonal closeness, intimacy and empathy) have been less frequently studied in self-administration models...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27909939/a-novel-fuzzy-approach-for-automatic-brunnstrom-stage-classification-using-surface-electromyography
#15
Luca Liparulo, Zhe Zhang, Massimo Panella, Xudong Gu, Qiang Fang
Clinical assessment plays a major role in post-stroke rehabilitation programs for evaluating impairment level and tracking recovery progress. Conventionally, this process is manually performed by clinicians using chart-based ordinal scales which can be both subjective and inefficient. In this paper, a novel approach based on fuzzy logic is proposed which automatically evaluates stroke patients' impairment level using single-channel surface electromyography (sEMG) signals and generates objective classification results based on the widely used Brunnstrom stages of recovery...
December 1, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27909926/metals-as-chemical-tracers-to-discriminate-ecological-populations-of-threatened-franciscana-dolphins-pontoporia-blainvillei-from-argentina
#16
M B Romero, P Polizzi, L Chiodi, A Robles, K Das, M Gerpe
Franciscana dolphins are the most impacted small cetacean in the Southwestern Atlantic Ocean, classified as Vulnerable A3d by IUCN. Essential (Fe, Mo, Mn, Cr, Ni, Co) and non-essential (Ag, Pb, Sn) trace elements (TEs) were measured in liver, kidney, and brain samples of by-catch Franciscana dolphins that were living in estuarine (n = 21) and marine (n = 21) habitats (1) to assess whether TEs posed a threat and (2) to evaluate the suitability of TEs for discriminating ecological populations of this species in Argentinean waters...
December 1, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27909807/german-validation-of-the-bidq-s-questionnaire-on-body-image-disturbance-in-idiopathic-scoliosis
#17
Mark Wetterkamp, Meinald T Thielsch, Georg Gosheger, Patrick Boertz, Jan Henrik Terheyden, Tobias L Schulte
PURPOSE: The Body Image Disturbance Questionnaire-Scoliosis (BIDQ-S) is a seven-item questionnaire inquiring into patients' worries about back shape and associated problems at school, at work, with friends or family, and whether the patients are avoiding certain activities. The aim of this study was to translate the BIDQ-S into German (G-BIDQ-S), test its reliability, and establish its convergent, divergent, concurrent, and discriminant validity. METHODS: In a prospective cohort study, 259 patients with idiopathic scoliosis (mean age 30...
December 1, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27909775/gender-effect-on-public-stigma-changes-towards-psychosis-in-the-hong-kong-chinese-population-a-comparison-between-population-surveys-of-2009-and-2014
#18
S K W Chan, K W Lee, C L M Hui, W C Chang, E H M Lee, E Y H Chen
PURPOSE: Public stigma is an important barrier to the recovery of patients with psychosis. The current study aimed to investigate the change in stigma towards psychosis and knowledge about psychosis between 2009 and 2014 among the Chinese population in Hong Kong, with a specific focus on gender role. METHODS: Random telephone survey of general population in Hong Kong was conducted in 2009 and 2014. Stigma was measured with the revised Link's Perceived Discrimination-Devaluation Scale (LPDDS)...
December 1, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27909706/out-of-plane-integration-of-a-multimode-optical-fiber-for-single-particle-cell-detection-at-multiple-points-on-a-microfluidic-device-with-applications-to-particle-cell-counting-velocimetry-size-discrimination-and-the-analysis-of-single-cell-lysate-injections
#19
Jalal Sadeghi, Damith E W Patabadige, Anne H Culbertson, Hamid Latifi, Christopher T Culbertson
In this paper a single particle/cell-tracking microfluidic device that integrates an out-of-plane multimode optical fiber (OP-MMF) is reported. This OP-MMF is used to generate three excitation light-lines and three detection spots using only one excitation source and one detector. It takes advantage of an optical tunneling mode to create two excitation lines in a microfluidic channel emanating from a single fiber end. This method was used to accurately count particles/cells and perform velocity measurements and size discrimination...
December 2, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27909617/diagnostic-value-of-micrornas-in-prostate-cancer-patients-with-prostate-specific-antigen-psa-levels-between-2-and-10-ng-ml
#20
Serin Akbayır, Necati Muşlu, Sema Erden, Murat Bozlu
OBJECTIVE: Prostate specific antigen (PSA), used for the early diagnosis of prostate cancer (PCa), is one of the best tumour markers known so far. However, in situations when PSA is between 2-10 ng/mL, which is named as grey zone, PSA falls short of distinguishing benign prostate diseases from PCa. On the other hand, it was demonstrated in many previous studies that microRNA (miRNA) could be a marker for cancer. Therefore, in this study, it was aimed to enhance the diagnostic power of PSA, especially with grey zone patients, by the use of miRNA...
December 2016: Turkish Journal of Urology
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