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Qingwan Xue, Gustav Markkula, Xuedong Yan, Natasha Merat
Previous studies have shown the effect of a lead vehicle's speed, deceleration rate and headway distance on drivers' brake response times. However, how drivers perceive this information and use it to determine when to apply braking is still not quite clear. To better understand the underlying mechanisms, a driving simulator experiment was performed where each participant experienced nine deceleration scenarios. Previously reported effects of the lead vehicle's speed, deceleration rate and headway distance on brake response time were firstly verified in this paper, using a multilevel model...
June 18, 2018: Accident; Analysis and Prevention
Bowen Hu, Xi Yang, Huiliang Yang, Limin Liu, Peiran Chen, Linnan Wang, Ce Zhu, Chunguang Zhou, Yueming Song
BACKGROUND: Choosing the fusion level for posterior fusion in Lenke 5C adolescent idiopathic scoliosis patients is highly associated with coronal balance. Previous studies indicated that in patients with lowest end vertebra tilt > 25°, surgeons could extend distal fusion to avoid coronal imbalance. This study aimed to assess the risk factors for coronal imbalance in Lenke 5C scoliosis, and to discuss how to select fusion level. METHODS: We reviewed 59 Lenke 5C AIS patients in one institution with at least 2-years' follow-up from 2010 through 2015...
June 18, 2018: World Neurosurgery
Alexander Jones, Christian Rank, Yanik Becker, Christian Malchau, Ignacio Funes-Ardoiz, Feliu Maseras, Frederic William Patureau
The mechanism of a trinuclear cooperative dehydrogenative C-N bond forming reaction is investigated in this work, which avoids the use of chelate assisting directing groups. Two new highly efficient Ru/Cu co-catalyzed systems were identified, allowing three orders of magnitude greater TOFs than the previous state of the art. In-depth kinetic studies were performed in combination with advanced DFT calculations, which reveal a decisive rate-determining trinuclear Ru-Cu cooperative reductive elimination step (CRE)...
June 21, 2018: Chemistry: a European Journal
N L Gerlach
The aim of this study was to determine the accuracy of the pre-surgical assessment of the mandible using cone beam computed tomography (CBCT) images. For surgical procedures in the mandible, it is important to determine the position of the mandibular canal in order to avoid damage to the inferior alveolar nerve (IAN). The best method to investigate this nerve is with the help of panoramic reconstructed images combined with cross-sectional reconstructed images. To protect the IAN during treatment, this research indicates that a minimal safety zone of 1...
June 2018: Nederlands Tijdschrift Voor Tandheelkunde
Janine Steinberg, David Bauer, Falco Reissig, Martin Köckerling, Hans-Jürgen Pietzsch, Constantin Mamat
Invited for this month's cover picture is the group around Dr. Constantin Mamat at the Institute of Radiopharmaceutical Cancer Research at the Helmholtz-Zentrum Dresden-Rossendorf (Germany) together with Prof. Martin Köckerling from the University of Rostock (Germany). The cover picture shows the ability of special functionalized calix[4]crown-6 derivatives to stably bind group 2 metals like barium. This binding mode is highly important for radiopharmaceutical applications not to lose the respective radiometal in vivo to avoid high background signals and/or false positive results and damages in other tissues...
June 2018: ChemistryOpen
Lu Hong, Hui Qiu, Zijie Mei, Hui Zhang, Shaopin Liu, Hong Cao
Supra-clavicular lymph node metastasis from ovarian cancer is rare. The present study reports the unique case of a 43-years-old patient who initially presented with left supra-clavicular lymph node metastasis, and was nulliparous. According to fine-needle aspiration cytology of the metastatic left supra-clavicular lymph nodes and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) scan, the patient was diagnosed with poorly differentiated serous carcinoma of ovarian cancer, stage IV...
July 2018: Oncology Letters
Nobuyuki Maruyama, Kazuhide Nishihara, Toshiyuki Nakasone, Masanao Saio, Tessho Maruyama, Iori Tedokon, Tetsuya Ohira, Fumikazu Nimura, Akira Matayoshi, Ken-Nosuke Karube, Naoki Yoshimi, Akira Arasaki
Second primary malignancy (SPM) is a severe issue for cancer survivors, particularly for osteosarcoma (OS) survivors. To date, the associations between subsequent SPM and OS have been well reported. Hematogenic and solid malignancies tend to occur following OS treatment. Reportedly, 2-[18 F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) is mainly used in OS patients for initial cancer staging, to evaluate the response of neoadjuvant chemotherapy, and when recurrence or metastasis is clinically suspected...
June 2018: Oncology Letters
Thomas Brandt, Eva Grill, Michael Strupp, Doreen Huppert
Aims: To determine the susceptibility to visual height intolerance (vHI) in patients with acquired bilateral vestibulopathy (BVP). The question was whether postural instability in BVP, which is partially compensated for by visual substitution of the impaired vestibular control of balance, leads to an increased susceptibility. This is of particular importance since fear of heights is dependent on body posture, and visual control of balance at heights can no longer substitute vestibular input. For comparison susceptibility to vHI was determined in patients with other vestibular or functional disorders...
2018: Frontiers in Neurology
Lan Anh Trinh, Mikael Ekström, Baran Cürüklü
Recent industrial developments in autonomous systems, or agents, which assume that humans and the agents share the same space or even work in close proximity, open for new challenges in robotics, especially in motion planning and control. In these settings, the control system should be able to provide these agents a reliable path following control when they are working in a group or in collaboration with one or several humans in complex and dynamic environments. In such scenarios, these agents are not only moving to reach their goals, i...
2018: Frontiers in Neurorobotics
Aakash Mugalur
Equalizing limb length is of paramount importance for optimal outcome in patients undergoing hip arthroplasty(HA). Numerous techniques have been described for avoiding limb length discrepancy (LLD) in patients undergoing HA. However their applicability in patients undergoing HA for neck of femur(NOF) fractures remains questionable due to dissociation between the femur and the head. I hereby describe a novel yet simple technique for better utilization of already established techniques to avoid LLD in NOF fractures undergoing HA...
June 2018: Journal of Clinical Orthopaedics and Trauma
Manuel Robustillo, Luis Parra Pont, Georgios Pafitanis, Pedro Ciudad, Daniel Grandes, Israel Iglesias
DIEP flap has become the gold standard method for patients undergoing autologous breast reconstruction; however, previous surgery or scars in the abdominal area have been considered a relative contraindication for the use of abdominal tissue. Longitudinal midline abdominal scars may be specially problematic because of the poor midline crossover of blood and the high risk of necrosis of the distal flap. Patients with small breast may be easily reconstructed with hemi-DIEP flap; however, patients with large breast need more tissue available...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Medha Anand Bhave
Context: Seroma formation is a common complication after lipoabdominoplasty. Conventionally, drains have been placed to prevent seroma; however, there are problems with drains, namely, pain, compromised mobilisation, breakage, tissue irritation and infection. Strategies to prevent seroma, such as the use of glue or quilting sutures have all been attempted with variable and unpredictable benefit. Aims: The author extrapolated the experience with own liposuction protocols to lipoabdominoplasty and began doing away with drains from the year 2006 onwards unless absolutely indicated...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Brian M Sweis, Mark J Thomas, A David Redish
Regret can be defined as the subjective experience of recognizing that one has made a mistake and that a better alternative could have been selected. The experience of regret is thought to carry negative utility. This typically takes two distinct forms: augmenting immediate postregret valuations to make up for losses, and augmenting long-term changes in decision-making strategies to avoid future instances of regret altogether. While the short-term changes in valuation have been studied in human psychology, economics, neuroscience, and even recently in nonhuman-primate and rodent neurophysiology, the latter long-term process has received far less attention, with no reports of regret avoidance in nonhuman decision-making paradigms...
June 2018: PLoS Biology
Rachel L O'Connell, Rosa Di Micco, Komel Khabra, Anna M Kirby, Paul A Harris, Stuart E James, Kieran Power, Kelvin Wd Ramsey, Jennifer E Rusby
INTRODUCTION: The aim of this study was to investigate aesthetic outcome and patient satisfaction in women who have undergone DIEP reconstruction in the setting of PMRT. Patients who underwent DIEP reconstruction without PMRT were the control group. METHODS: Participants who had undergone DIEP between 9/1/2009-9/1/2014 were recruited, answered the BREAST-Q and underwent 3D surface-imaging. A panel assessed the aesthetic outcome by reviewing these images. RESULTS: 167 women participated...
June 12, 2018: Plastic and Reconstructive Surgery
Cecilia L Dalle Ore, Peter Abraham, Luke P Burns, Samuel Lance, Amanda Gosman, Hal S Meltzer
Reconstructive cranioplasty can be associated with many complications and add to the not insignificant potential risks associated with decompressive craniectomy. In the setting of post-traumatic hydrocephalus, treatment with a ventriculoperitoneal (VP) shunt prior to reconstructive cranioplasty likely increases these risks even further. The authors report a case of a 17-year-old male with a history of a severe closed head injury who initially suffered a life-threatening complication associated with intracranial hypotension after cranioplasty only to succumb to malignant intracranial hypertension following a second cranioplasty attempt...
June 20, 2018: Journal of Craniofacial Surgery
Rukiye Çolak Sivri, Hayriye Hizarcioğlu Gülşen, Arzu Yilmaz
Phagophobia is a condition characterized by an avoidance of swallowing foods and an intense fear of choking while eating solid foods in the absence of physiological and anatomical abnormalities. Phagophobia is mentioned in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and International Classification of Diseases, 11th Edition in the new diagnostic category of avoidant/restrictive food intake disorder. The literature concerning phagophobia is sparse, and there is no specific treatment modality for this life-threatening condition...
June 20, 2018: Clinical Neuropharmacology
Mohamed M Nasr
PURPOSE: Central pancreatectomy (CP) has been used sparingly because the spectrum of indications is quite narrow. The author has modified the procedure of CP in such a way to avoid distal pancreatic segment drainage, in addition to reserving the patient euo-insulinemic. MATERIALS AND METHODS: Between March 2010 and January 2015, 41 cases have been recruited. Cases presented with blunt abdominal trauma showing central pancreatic transection with or without duodenal transection have been recruited...
June 20, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Paul Phamduy, John-Ross Rizzo, Todd E Hudson, Marina Torre, Kalle Levon, Maurizio Porfiri
Research into sensory substitution systems has expanded, as alternative senses are utilized in real-time to afford object recognition or spatial understanding. Tactile stimulation has long shown promise as a communicatory strategy when applied unobtrusively to the redundant surface areas of the skin. Here, a novel belt, integrating a matrix of macro fiber composites, is purposed to deliver tactile stimuli to the abdomen. The design and development of the belt is presented and a systematic experimental study is conducted to analyze the impact of frequency and duty cycle...
April 2018: IEEE Transactions on Haptics
David H Smith, Maureen O'Keeffe Rosetti, David M Mosen, A Gabriela Rosales, Erin Keast, Nancy Perrin, Adrianne C Feldstein, Theodore R Levin, Elizabeth G Liles
Colorectal cancer (CRC) causes more than 50,000 deaths each year in the United States but early detection through screening yields survival gains; those diagnosed with early stage disease have a 5-year survival greater than 90%, compared to 12% for those diagnosed with late stage disease. Using data from a large integrated health system, this study evaluates the cost-effectiveness of fecal immunochemical testing (FIT), a common CRC screening tool. A probabilistic decision-analytic model was used to examine the costs and outcomes of positive test results from a 1-FIT regimen compared with a 2-FIT regimen...
June 21, 2018: Population Health Management
Alessandro Cuomo, Giuseppe Maina, Stephen M Neal, Graziella De Montis, Gianluca Rosso, Simona Scheggi, Bruno Beccarini Crescenzi, Simone Bolognesi, Arianna Goracci, Anna Coluccia, Fabio Ferretti, Andrea Fagiolini
The World Health Organization recommends newborns to be breastfed but this may be challenging if the mother needs to be treated for depression, since strong evidence to inform treatment choice is missing. Areas covered: We provide a critical review of the literature to guide clinicians who are considering sertraline for the management of depression during postpartum. Expert opinion: Sertraline is one of the safest antidepressants during breastfeeding. In most cases, women already taking sertraline should be advised to breastfeed and continue the medication...
June 21, 2018: Expert Opinion on Drug Safety
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