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https://www.readbyqxmd.com/read/29679952/injuries-to-cyclists-due-to-a-dog-bicycle-interaction
#1
Randall T Loder, Alan P Yaacoub
BACKGROUND:  Both dogs and bicycles are common in our society and thus a dog-bicycle interaction resulting in an injury to a cyclist is possible. It was the purpose of this study to investigate such injuries. METHODS:  The National Electronic Injury Surveillance System (NEISS) data for the 10-year period from 2006 through 2015 associated with bicycles were accessed. Injuries involving dogs were identified and the mechanism of injury determined. Due to the stratified and weighted nature of the NEISS data, statistical analyses were performed with SUDAAN 10 software (RTI International, Research Triangle Park, North Carolina, United States)...
April 21, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#2
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679914/a-multi-site-proof-of-concept-investigation-of-computerized-approach-avoidance-training-in-adolescent-cannabis-users
#3
Joanna Jacobus, Charles T Taylor, Kevin M Gray, Lindsay R Meredith, Anna M Porter, Irene Li, Norma Castro, Lindsay M Squeglia
BACKGROUND: Few effective treatment options exist for cannabis-using youth. This pilot study aimed to test Approach-Avoidance Training to reduce cannabis use with non-treatment-seeking adolescents. METHODS: Eighty cannabis-using non-treatment-seeking adolescents (average age 19) were recruited from San Diego, California and Charleston, South Carolina, and randomized to complete either six sessions of Cannabis Approach-Avoidance Task Training (CAAT-training) designed to reduce automatic approach biases for cannabis cues or CAAT-sham training...
April 11, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29679825/technologies-for-the-management-of-msw-incineration-ashes-from-gas-cleaning-new-perspectives-on-recovery-of-secondary-raw-materials-and-circular-economy
#4
REVIEW
Margarida J Quina, Elza Bontempi, Anna Bogush, Stefan Schlumberger, Gisela Weibel, Roberto Braga, Valerio Funari, Jiri Hyks, Erik Rasmussen, Jakob Lederer
Environmental policies in the European Union focus on the prevention of hazardous waste and aim to mitigate its impact on human health and ecosystems. However, progress is promoting a shift in perspective from environmental impacts to resource recovery. Municipal solid waste incineration (MSWI) has been increasing in developed countries, thus the amount of air pollution control residues (APCr) and fly ashes (FA) have followed the same upward trend. APCr from MSWI is classified as hazardous waste in the List of Waste (LoW) and as an absolute entry (19 01 07*), but FA may be classified as a mirror entry (19 0 13*/19 01 14)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679820/joy-guilt-and-disappointment-an-interpretative-phenomenological-analysis-of-the-experiences-of-women-transferred-from-midwifery-led-to-consultant-led-care
#5
Patricia Larkin
BACKGROUND: Irish maternity services are predominantly medicalised and consultant led, therefore women who choose midwifery led care (MLC) do so in the context of limited birth choices. Transfers to consultant led unit (CLU) for consultant led care (CLC) can be unpredictable and can affect women's birth experiences. This study provides an in-depth exploration of women's experiences of transfer fromMLC to CLC during late pregnancy or labour. METHODS: Transfer experiences are explored through qualitative explorative in-depth interviews using interpretative phenomenological analysis (IPA)...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29679795/self-controlled-release-of-oxaliplatin-prodrug-from-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-tpgs-functionalized-mesoporous-silica-nanoparticles-for-cancer-therapy
#6
Chaoyu Liang, Heping Wang, Min Zhang, Wei Cheng, Zihuang Li, Junpeng Nie, Gan Liu, Daizheng Lian, Zhenhua Xie, Laiqiang Huang, Xiaowei Zeng
Oxaliplatin is a promising antitumor drug, but its effectiveness is limited by its side effects in vivo. In this study, we introduced an Oxaliplatin prodrug (Oxa(IV)) self-controlled release strategy, in which Oxa(IV) is encapsulated by TPGS functionalized mesoporous silica nanoparticles (MSNs), and its release is controlled by biological stimuli, such as acidic environments in tumor tissue and high concentrations of reductants in cancer cells. Despite the lack of auxiliary "gatekeepers" to MSNs, this simplified model of Oxa(IV)-MSNs-TPGS could fine-tune the movements of the drug release...
April 16, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679730/stand-alone-lateral-lumbar-interbody-fusion-for-the-treatment-of-symptomatic-adjacent-segment-degeneration-following-previous-lumbar-fusion
#7
Philip K Louie, Arya G Varthi, Ankur S Narain, Victor Lei, Daniel D Bohl, Grant D Shifflett, Frank M Phillips
BACKGROUND CONTEXT: Revision posterior decompression and fusion for patients with symptomatic ASD is associated with significant morbidity and is technically challenging. The use of a stand-alone LLIF in patients with symptomatic ASD may avoid many of the complications associated with revision posterior surgery. PURPOSE: To assess the clinical and radiographic outcomes of patients who underwent stand-alone lateral lumbar interbody fusion (LLIF) for symptomatic adjacent segment disease (ASD)...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679724/harvest-and-trade-of-caterpillar-mushroom-ophiocordyceps-sinensis-and-the-implications-for-sustainable-use-in-the-tibet-region-of-southwest-china
#8
Jun He
ETHNOPHARMACOLOGICAL RELEVANCE: caterpillar mushroom (Ophiocordyceps sinensis) is a unique medicinal fungi which is only found in alpine grasslands in Himalayan mountain regions and the Tibetan Plateau. Known locally as Yartsa Gunbu, it has been widely used in Tibetan and Chinese Medicine for centuries. It is crucial to understand local commercial harvest and trade practices of caterpillar mushroom to support the sustainable management of this valuable resource. However, data derived from empirically grounded research is currently limited, particularly in China...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#9
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679572/a-novel-strategy-to-improve-the-thermostability-of-penicillium-camembertii-mono-and-di-acylglycerol-lipase
#10
Yanhua Liu, Dongjuan Yuan, Zexin Zhao, Dongming Lan, Bo Yang, Yonghua Wang
Penicillium camembertii (PCL), a mono- and di-acylglycerol lipase (DGL), has the vital potential in the oil chemistry for food industry. However, known DGLs are mesophilic enzymes which restricts its application in the industry. To improve thermostability of PCL, we used amino acid substitution by comparison of amino acids compositions of PCL and protein sequences from typical thermophilic bacteria. Then, some conservative residues around active center were avoided to mutate according to homologous alignment analyses...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679561/drosophila-nucleostemin-3-is-required-to-maintain-larval-neuroblast-proliferation
#11
Patrick W Johnson, Chris Q Doe, Sen-Lin Lai
Stem cells must maintain proliferation during tissue development, repair and homeostasis, yet avoid tumor formation. In Drosophila, neural stem cells (neuroblasts) maintain proliferation during embryonic and larval development and terminate cell cycle during metamorphosis. An important question for understanding how tissues are generated and maintained is: what regulates stem cell proliferation versus differentiation? We performed a genetic screen which identified nucleostemin 3 (ns3) as a gene required to maintain neuroblast proliferation...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#12
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29679289/cross-state-dependency-of-learning-between-tramadol-and-mk-801-in-the-mouse-dorsal-hippocampus-involvement-of-nitric-oxide-no-signaling-pathway
#13
Majid Jafari-Sabet, Shiva Amiri, Ramin Ataee
RATIONALE: Tramadol, an atypical μ-opioid receptor agonist, as a psychoactive drug, is frequently abused by human beings. Understanding the neurobiological mechanisms of drug-associated learning and memory formation may help prevent drug addiction and relapse. Previous study revealed that dorsal hippocampus (CA1) plays a crucial role in the retrieval of tramadol-associated memory and that its role depends on the expression of CA1 N-methyl-D-aspartate (NMDA) receptors (Jafari-Sabet et al...
April 21, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29679245/a-systematic-review-of-minimally-invasive-surgery-for-retrorectal-tumors
#14
REVIEW
T G Mullaney, A L Lightner, M Johnston, S R Kelley, D W Larson, E J Dozois
Retrorectal tumors are rare tumors that require resection for symptoms, malignancy and potential malignant transformation. Traditional approaches have included laparotomy, perineal excision or a combination. Multiple minimally invasive techniques are available which have the potential to minimize morbidity and enhance recovery. We performed a systematic review of the literature to determine the feasibility and surgical outcomes of retrorectal tumors approached using minimally invasive surgical techniques. Publications in which adult patients (≥ 18 years) had a minimally invasive approach (laparoscopic or robotic) for resection of a primary retrorectal tumor were included...
April 20, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29679242/automatic-organ-segmentation-for-ct-scans-based-on-super-pixel-and-convolutional-neural-networks
#15
Xiaoming Liu, Shuxu Guo, Bingtao Yang, Shuzhi Ma, Huimao Zhang, Jing Li, Changjian Sun, Lanyi Jin, Xueyan Li, Qi Yang, Yu Fu
Accurate segmentation of specific organ from computed tomography (CT) scans is a basic and crucial task for accurate diagnosis and treatment. To avoid time-consuming manual optimization and to help physicians distinguish diseases, an automatic organ segmentation framework is presented. The framework utilized convolution neural networks (CNN) to classify pixels. To reduce the redundant inputs, the simple linear iterative clustering (SLIC) of super-pixels and the support vector machine (SVM) classifier are introduced...
April 20, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29679166/composite-resection-of-the-left-upper-lobe-and-superior-segment-s6-of-the-lower-lobe-for-lung-cancer-with-a-mediastinal-lingular-and-basal-pulmonary-artery
#16
Tomoyuki Nakano, Shigemi Ishikawa, Yasunori Sohara, Shunsuke Endo
BACKGROUND: Preoperative evaluation and awareness of anatomical variations in the pulmonary vessel is essential for a secure pulmonary resection. We herein present a patient who underwent complex pulmonary resection for lung cancer with a mediastinal lingular and basal pulmonary artery that had been detected by preoperative three-dimensional computed tomography. CASE PRESENTATION: The patient was an asymptomatic 66-year-old woman who had a 39-pack-year smoking habit...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29679142/conflict-modification-predictable-production-of-congruent-situations-facilitates-responding-in-a-stroop-task
#17
Constantin Schmidts, Anna Foerster, Wilfried Kunde
Humans cope with cognitive conflict in various ways, such as focusing on task-relevant instead of task-irrelevant information or avoiding situations where conflict is likely. These adaptations to conflict resemble those used to cope with negative affect. We examined whether situation modification, a strategy derived from the extended process model of emotion regulation, may influence responding in cognitive conflict tasks. This should be evident by a facilitation of actions that consistently modify situations towards congruent (positive) situations rather than to incongruent (negative) situations...
April 20, 2018: Psychological Research
https://www.readbyqxmd.com/read/29679032/comparison-of-an-unsupervised-machine-learning-algorithm-and-surgeon-diagnosis-in-the-clinical-differentiation-of-metopic-craniosynostosis-and-benign-metopic-ridge
#18
Min-Jeong Cho, Rami R Hallac, Maleeh Effendi, James R Seaward, Alex A Kane
Metopic suture closure can manifest as a benign metopic ridge (BMR), a variant of normal, to "true" metopic craniosynostosis (MCS), which is associated with severe trigonocephaly. Currently, there is no gold standard for how much associated orbitofrontal dysmorphology should trigger surgical intervention. In our study, we used three-dimensional (3D) curvature analysis to separate the phenotypes along the spectrum, and to compare surgeons' thresholds for operation. Three-dimensional curvature analyses on 43 subject patients revealed that the mean curvature of mid-forehead vertical ridge was higher for patients who underwent operation than those who did not undergo operation by 1...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678952/subverting-the-mechanisms-of-cell-death-flavivirus-manipulation-of-host-cell-responses-to-infection
#19
REVIEW
Elisa Vicenzi, Isabel Pagani, Silvia Ghezzi, Sarah L Taylor, Timothy R Rudd, Marcelo A Lima, Mark A Skidmore, Edwin A Yates
Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, cells and tissues. Flaviviruses are largely transmitted by mosquito bites and humans are usually incidental, dead-end hosts, with the notable exceptions of YFV, DENV and ZIKV. Infection by flaviviruses elicits cellular responses including cell death via necrosis, pyroptosis (involving inflammation) or apoptosis (which avoids inflammation)...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29678929/antibiotic-use-after-removal-of-penicillin-allergy-label
#20
David Vyles, Asriani Chiu, John Routes, Mariana Castells, Elizabeth J Phillips, Jennifer Kibicho, David C Brousseau
BACKGROUND: Penicillin allergy is commonly reported in the pediatric emergency department. We previously performed 3-tier penicillin allergy testing on children with low-risk symptoms, and 100% tolerated a penicillin challenge without an allergic reaction. We hypothesized that no serious allergic reactions would occur after re-exposure to penicillin and that prescription practices would change after testing. METHODS: We performed a follow-up case series of 100 children whose test results were negative for penicillin allergy...
April 20, 2018: Pediatrics
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