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https://www.readbyqxmd.com/read/29224235/long-term-cardiovascular-re-programming-by-short-term-perinatal-exposure-to-nicotine-s-main-metabolite-cotinine
#1
Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen
AIM: Gather "proof-of-concept" evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine / tobacco smoke exposure). METHODS: Pregnant C57 mice drank nicotine or cotinine-laced water for 6wks from conception (NPRE = 2% saccharin+100μg nicotine/ml; CPRE = 2% saccharin + 10μg cotinine/ml) or 3wks after birth (CPOST = 2% saccharin + 30μg cotinine/ml). Controls drank 2% saccharin (CTRL). At 17±1weeks (male pups; CTRL n=6; CPOST n=6; CPRE n=8; NPRE n=9) we assessed (i) cardiovascular control during sleep; (ii) arterial reactivity ex vivo; (iii) expression of genes involved in arterial constriction / dilation...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29224063/an-efficient-scheme-for-mental-task-classification-utilizing-reflection-coefficients-obtained-from-autocorrelation-function-of-eeg-signal
#2
M M Rahman, M A Chowdhury, S A Fattah
Classification of different mental tasks using electroencephalogram (EEG) signal plays an imperative part in various brain-computer interface (BCI) applications. In the design of BCI systems, features extracted from lower frequency bands of scalp-recorded EEG signals are generally considered to classify mental tasks and higher frequency bands are mostly ignored as noise. However, in this paper, it is demonstrated that high frequency components of EEG signal can provide accommodating data for enhancing the classification performance of the mental task-based BCI...
December 9, 2017: Brain Informatics
https://www.readbyqxmd.com/read/29224058/systematic-assessment-and-characterization-of-chronic-pain-in-multiple-sclerosis-patients
#3
Diana Ferraro, Domenico Plantone, Franca Morselli, Giulia Dallari, Anna M Simone, Francesca Vitetta, Patrizia Sola, Guido Primiano, Viviana Nociti, Matteo Pardini, Massimiliano Mirabella, Catello Vollono
Pain is one of the most disabling clinical symptoms in patients with multiple sclerosis (MS). Several studies have already assessed the prevalence of pain in MS patients, reporting variable results, probably due to methodological differences. The aim of this single-centre cross-sectional study was to define the prevalence and characteristics of chronic pain in a population of MS patients using validated tools, and to analyse these data in relation to demographic and clinical features, including disease duration and disability (EDSS and its single functional system scores)...
December 9, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29224050/maldi-imaging-combined-with-laser-microdissection-based-microproteomics-for-protein-identification-application-to-intratumor-heterogeneity-studies
#4
Rémi Longuespée, Deborah Alberts, Dominique Baiwir, Gabriel Mazzucchelli, Nicolas Smargiasso, Edwin De Pauw
Matrix-assisted laser desorption ionization (MALDI) imaging is widely used for in situ proteomic mapping and finds multiple applications in pathology. However, low fragmentation yields in MALDI avoid an optimal identification of peptides from tissues. On the other hand, LMD-based microproteomic analyses allow for the identification of hundreds to thousands of proteins from small tissue regions. Herein, we present the combination of MALDI imaging and LMD-based microproteomic approaches for parallel identification...
December 10, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224023/negative-symptoms-and-avoidance-of-social-interaction-a-study-of-non-verbal-behaviour
#5
Elizabeth Worswick, Sara Dimic, Christiane Wildgrube, Stefan Priebe
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. SAMPLING AND METHODS: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped...
December 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/29223875/snakes-exhibit-tissue-specific-variation-in-cardiotonic-steroid-sensitivity-of-na-k-atpase
#6
Shabnam Mohammadi, Georg Petschenka, Susannah S French, Akira Mori, Alan H Savitzky
Toads are among several groups of organisms chemically defended with lethal concentrations of cardiotonic steroids. As a result, most predators that prey on amphibians avoid toads. However, several species of snakes have gained resistance-conferring mutations of Na+/K+-ATPase, the molecular target of cardiotonic steroids, and can feed on toads readily. Despite recent advances in our understanding of this adaptation at the genetic level, we have lacked functional evidence for how mutations of Na+/K+-ATPase account for cardiotonic steroid resistance in snake tissues...
December 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29223794/a-new-t2-lesion-in-a-patient-with-the-clinically-isolated-syndrome-does-not-necessarily-imply-a-conversion-to-multiple-sclerosis
#7
Fioravante Capone, Marco Puthenparampil, Carlo Augusto Mallio, Alessandra Ida Celia, Lucia Florio, Paolo Gallo, Vincenzo Di Lazzaro
In the follow-up of patients with the clinically isolated syndrome, both clinical and MRI findings should be carefully evaluated by clinicians to avoid misinterpretation and inappropriate diagnosis of multiple sclerosis. We describe a case of a patient with a previous diagnosis of clinically isolated syndrome who developed a new asymptomatic brain lesion at the MRI follow-up. The careful evaluation of clinical history and radiological findings allowed the correct diagnosis of cocaine-associated ischemic stroke...
December 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29223742/network-analysis-reveals-disrupted-functional-brain-circuitry-in-drug-naive-social-anxiety-disorder
#8
REVIEW
Xun Yang, Jin Liu, Yajing Meng, Mingrui Xia, Zaixu Cui, Xi Wu, Xinyu Hu, Wei Zhang, Gaolang Gong, Qiyong Gong, John A Sweeney, Yong He
Social anxiety disorder (SAD) is a common and disabling condition characterized by excessive fear and avoidance of public scrutiny. Neuroimaging studies have suggested that the emotional and behavior deficits in SAD are associated with abnormalities in regional brain function and functional connectivity. However, little is known about whether intrinsic functional brain networks in patients with SAD are topologically disrupted. Here, we collected resting-state fMRI data from 33 drug-naive patients with SAD and 32 healthy controls (HC), constructed functional networks with 34 predefined regions based on previous meta-analytic research with task-based fMRI in SAD, and performed network-based statistic and graph-theory analyses...
December 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29223710/behavioral-responses-of-cd-1-mice-to-conspecific-and-heterospecific-blood-odors-and-to-a-blood-odor-component
#9
Christian Lahger, Matthias Laska
The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species we assessed behavioral responses of male CD-1 mice (n=60) to the odor of blood of same-sex and opposite-sex conspecifics, of a natural predator of mice (cat), and of a herbivore (horse) and an omnivore (human) non-predator of mice. Further, we assessed their behavior towards the mammalian blood odor component trans-4,5-epoxy-(E)-2-decenal which recent studies have shown to be as attractive to mammalian predators as the odor of real blood...
December 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29223626/sleep-and-quality-of-life-of-patients-with-glycogen-storage-disease-on-standard-and-modified-uncooked-cornstarch
#10
Isabelle Rousseau-Nepton, Céline Huot, Diane Laforte, Elise Mok, Daphna Fenyves, Evelyn Constantin, John Mitchell
BACKGROUND: Glycemic control in hepatic glycogen storage diseases (GSDs) relies on specific nutritional recommendations, including strict avoidance of a fasting period. Uncooked cornstarch (UCCS) is an important therapeutic component. A new modified UCCS, Glycosade™, was created with the objective of prolonging euglycemia. We aimed to determine the length of euglycemia on Glycosade™ using a continuous glucose monitor (CGM) and to evaluate whether longer euglycemia and thus less nighttime interruptions would improve sleep and quality of life (QoL) after the introduction of the modified cornstarch...
September 11, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29223518/synchronous-central-nervous-system-atypical-teratoid-rhabdoid-tumor-and-malignant-rhabdoid-tumor-of-the-kidney-case-report-of-a-long-term-survivor-and-review-of-the-literature
#11
Mohammad H Abu Arja, Priyal Patel, Summit H Shah, Jeffery J Auletta, Erin K Meyer, Suzanne E Conley, Jennifer H Aldrink, Jonathan A Pindrik, Mohamed S AbdelBaki
BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) with synchronous or metachronous extra-CNS disease is a rare childhood malignancy with a dismal prognosis. CASE DESCRIPTION: We report a seven-week-old female with metastatic AT/RT and synchronous malignant rhabdoid tumor of the kidney who received an intensive multimodal approach combining surgical resection, intrathecal chemotherapy, and high-dose chemotherapy with autologous peripheral blood stem cell transplant (PBSCT)...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29223451/mineralization-in-newborn-calves-contributes-to-health-improve-the-antioxidant-system-and-reduces-bacterial-infections
#12
Patrícia Glombowsky, Aleksandro S da Silva, Natan M Soldá, Gabriela M Galli, Angelisa H Biazus, Gabriela Campigotto, Nathieli B Bottari, Rejane S Sousa, Maiara C Brisola, Lenita M Stefani, Matheus D Baldissera, Marta L R Leal, Vera M Morsch, Maria Rosa C Schetinger, Gustavo Machado
The first phase of life of dairy calves has elevated mortality indices linked with low immunity and sanitary challenges, mainly bacterial infections are involved in the pathogenesis of diarrhea, the leading cause of death. Also, other important problem is the nutritional deficiencies, such as the mineral deficiency. Thus, the aim of this study was to evaluate whether an intramuscular mineral supplementation based on selenium, copper, potassium, magnesium and phosphorus possess beneficial effects on health of dairy calves...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29223345/synergy-between-root-hydrotropic-response-and-root-biomass-in-maize-zea-mays-l-enhances-drought-avoidance
#13
Delfeena Eapen, Jesús Martínez-Guadarrama, Oralia Hernández-Bruno, Leonardo Flores, Jorge Nieto-Sotelo, Gladys I Cassab
Roots of higher plants change their growth direction in response to moisture, avoiding drought and gaining maximum advantage for development. This response is termed hydrotropism. There have been few studies of root hydrotropism in grasses, particularly in maize. Our goal was to test whether an enhanced hydrotropic response of maize roots correlates with a better adaptation to drought and partial/lateral irrigation in field studies. We developed a laboratory bioassay for testing hydrotropic response in primary roots of 47 maize elite DTMA (Drought Tolerant Maize for Africa) hybrids...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29223183/conversion-between-addenbrooke-s-cognitive-examination-iii-and-mini-mental-state-examination
#14
Jordi A Matías-Guiu, Vanesa Pytel, Ana Cortés-Martínez, María Valles-Salgado, Teresa Rognoni, Teresa Moreno-Ramos, Jorge Matías-Guiu
BACKGROUND: We aim to provide a conversion between Addenbrooke's Cognitive Examination III (ACE-III) and Mini-Mental State Examination (MMSE) scores, to predict the MMSE result based on ACE-III, thus avoiding the need for both tests, and improving their comparability. METHODS: Equipercentile equating method was used to elaborate a conversion table using a group of 400 participants comprising healthy controls and Alzheimer's disease (AD) patients. Then, reliability was assessed in a group of 100 healthy controls and patients with AD, 52 with primary progressive aphasia and 22 with behavioral variant frontotemporal dementia...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223137/sysmex-uf-1000i-flow-cytometer-to-screen-urinary-tract-infections-the-uriscam-multicentre-study
#15
O Herráez, M A Asencio, R Carranza, M M Jarabo, M Huertas, O Redondo, A Arias, S Jiménez-Álvarez, S Solís, P Zamarrón, M S Illescas, M A Galán
The new Sysmex UF-1000i analyzer - which incorporates bacteria morphology distinction - allows to automatically screen samples to be cultured at microbiology laboratories. We have evaluated the feasibility and accuracy of Sysmex UF-1000i to screen urine tract infections (UTIs). A total amount of 2,468 urine samples from six Spanish hospitals were analysed. Demographic and clinical data such as age, gender, source and sample type, preserving conditions, cytometer parameters (bacteria, leucocytes, and bacteria morphology) as well as urine culture results (gold standard) were recorded...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29223081/dispersion-of-traffic-derived-air-pollutants-into-urban-parks
#16
Yang Xing, Peter Brimblecombe
Scarce land resources in dense cities means that small urban parks are important as a leisure and amenity resource for the urban population. However, streets with heavily traffic often surround these fragmented parks and increase the potential user exposure to air pollutants from vehicles. The dispersion profiles of PM2.5 and black carbon from roadside into urban parks at pedestrian level, in Hong Kong, were measured using mobile high time resolution instruments. In the downwind direction, pollutant concentrations decreased rapidly from roadside and by some tens of metres reached relatively constant values...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223052/wavelength-selection-for-portable-noninvasive-blood-component-measurement-system-based-on-spectral-difference-coefficient-and-dynamic-spectrum
#17
Ximeng Feng, Gang Li, Haixia Yu, Shaohui Wang, Xiaoqing Yi, Ling Lin
Noninvasive blood component analysis by spectroscopy has been a hotspot in biomedical engineering in recent years. Dynamic spectrum provides an excellent idea for noninvasive blood component measurement, but studies have been limited to the application of broadband light sources and high-resolution spectroscopy instruments. In order to remove redundant information, a more effective wavelength selection method has been presented in this paper. In contrast to many common wavelength selection methods, this method is based on sensing mechanism which has a clear mechanism and can effectively avoid the noise from acquisition system...
November 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29222990/rapid-and-irreversible-sorption-behavior-of-7be-assessed-to-evaluate-its-use-as-a-catchment-sediment-tracer
#18
N Ryken, B Al-Barri, W Blake, A Taylor, F M G Tack, E Van Ranst, S Bodé, P Boeckx, A Verdoodt
Beryllium-7 (7Be) has been used as a sediment tracer to evaluate soil redistribution rates at hillslopes and as a tool to estimate sediment residence time in river systems. A key assumption for the use of 7Be as a sediment tracer is the rapid and irreversible sorption of 7Be upon contact with the soil particles. However, recent studies have raised questions about the validity of these assumptions. Seven soil types were selected to assess the adsorption rate of 7Be on the soil particles, subsequently an extraction experiment was performed to assess the rate of desorption...
December 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29222978/cobalt-nanofibers-coated-with-layered-nickel-silicate-coaxial-core-shell-composites-as-excellent-anode-materials-for-lithium-ion-batteries
#19
Xuefang Chen, Ying Huang, Kaichuang Zhang
A novel type of cobalt nanofibers coated with layered nickel silicate (Co nanofibers @ voids @ Ni3Si2O5(OH)4) coaxial core-shell composites were successfully prepared via a well-known Stöber process and two hydrothermal methods. In the composites, the international nanosheet structure of the nickel silicate provided interlayer spaces for lithium ions in the process of insertion and extraction. The cobalt nanofibers served as a mechanical support for the nickel silicate nanosheets, which increased the electrical conductivity of the whole electrode...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29222814/siena-xl-for-improving-the-assessment-of-gray-and-white-matter-volume-changes-on-brain-mri
#20
Marco Battaglini, Mark Jenkinson, Nicola De Stefano
In this article, SIENA-XL, a new segmentation-based longitudinal pipeline is introduced, for: (i) increasing the precision of longitudinal volume change estimation for white (WM) and gray (GM) matter separately, compared with cross-sectional segmentation methods such as SIENAX; and (ii) avoiding potential biases in registration-based methods when Jacobians are used, with a smoothing extent larger than spatial scale between tissue-interfaces, which is where atrophy usually occurs. SIENA-XL implements a new brain extraction procedure and a multi-time-point intensity equalization step before performing the final segmentation that also includes separate segmentation of deep GM structures by using FMRIB's Integrated Registration and Segmentation Tool...
December 8, 2017: Human Brain Mapping
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