Jie Yang, Lin Lin, Guang-Jing Zou, Lai-Fa Wang, Fang Li, Chang-Qi Li, Yan-Hui Cui, Fu-Lian Huang
Cognitive behavioral therapy, rooted in exposure therapy, is currently the primary approach employed in the treatment of anxiety-related conditions, including post-traumatic stress disorder (PTSD). In laboratory settings, fear extinction in animals is a commonly employed technique to investigate exposure therapy; however, the precise mechanisms underlying fear extinction remain elusive. Casein kinase 2 (CK2), which regulates neuroplasticity via phosphorylation of its substrates, has a significant influence in various neurological disorders, such as Alzheimer's disease and Parkinson's disease, as well as in the process of learning and memory...
March 15, 2024: Behavioural Brain Research