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https://www.readbyqxmd.com/read/29135613/68ga-dotatate-uptake-in-ischemic-stroke
#1
Émilie Vallée, Nancy Paquet, James Patrick Buteau, Éric Turcotte
A 76-year-old man known to have a pancreatic neuroendocrine tumor with hepatic and lymph nodes metastasis had a follow-up Ga-DOTATATE PET/CT before Lu-DOTATATE therapy. A new cerebral lesion expressing somatostatin receptors was discovered in the right temporal lobe, suggestive of an ischemic stroke territory. This was later confirmed from the hospital chart where an ischemic stroke was described a month ago.
November 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29133263/prospective-evaluation-of-pasireotide-in-patients-undergoing-pancreaticoduodenectomy-the-washington-university-experience
#2
Ismael Dominguez-Rosado, Ryan C Fields, Cheryl A Woolsey, Gregory Williams, Timothy A Horwedel, J Bart Rose, Chet W Hammill, Maria B Doyle, William C Chapman, Steven M Strasberg, William G Hawkins, Dominic E Sanford
BACKGROUND: Pasireotide is a newer generation somatostatin analogue which led to a significant reduction in pancreatic fistula after pancreatectomy in a single-center randomized controlled trial. We sought to determine if pasireotide reduces the incidence of pancreatic fistula and other complications following pancreaticoduodenectomy at our high volume center. STUDY DESIGN: All patients between April 2011 and January 2017 undergoing pancreaticoduodenectomy were prospectively followed and their complications graded using the Modified Accordion Grading System (MAGS) in our institutional complications database...
November 10, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29131531/modifying-expression-modes-of-human-neurotensin-receptor-type-1-alters-sensing-capabilities-for-agonists-in-yeast-signaling-biosensor
#3
Hiroki Hashi, Yasuyuki Nakamura, Jun Ishii, Akihiko Kondo
Neurotensin receptor type 1 (NTSR1), a member of the G-protein-coupled receptor (GPCR) family, is naturally activated by binding of a neurotensin peptide, leading to a variety of physiological effects. The budding yeast Saccharomyces cerevisiae is a proven host organism for assaying the agonistic activation of human GPCRs. Previous studies showed that yeast cells can functionally express human NTSR1 receptor, permitting the detection of neurotensin-promoted signaling using a ZsGreen fluorescent reporter gene...
November 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29127701/release-kinetics-of-somatostatin-from-self-assembled-nanostructured-hydrogels
#4
Uma Rai, Thilini R Thrimawithana, Durga Dharmadana, Celine Valery, Simon A Young
Somatostatin-14 is a native neuropeptide with widespread functions in the body. Self-assembly of somatostatin-14 into amyloid-like nanofibrils has been previously demonstrated in aqueous media. We here hypothesize that the somatostatin nanofibrils can form a stable depot that release monomers in a controlled manner. This study aims to investigate if somatostatin monomers are released from physical hydrogels formed in water and in the presence of electrolytes. The release kinetics of the somatostatin monomers is investigated for the first time...
November 11, 2017: Biopolymers
https://www.readbyqxmd.com/read/29124519/prognostic-and-predictive-role-of-the-pi3k-akt-mtor-pathway-in-neuroendocrine-neoplasms
#5
REVIEW
P Gajate, T Alonso-Gordoa, O Martínez-Sáez, J Molina-Cerrillo, E Grande
Neuroendocrine neoplasms (NENs) are considered a heterogeneous and rare entity. Its natural history is influenced by multiple clinicopathological characteristics, which guide the management of these patients. The development of molecular biology reveals that the PI3K-AKT-mTOR pathway plays a relevant role in tumorigenesis and progression of NENs. Mammalian target of rapamycin (mTOR) inhibitors, targeted agents that block this pathway, has improved outcomes in neuroendocrine tumors (NETs). Different therapeutic approaches, such as somatostatin analogs, chemotherapy, peptide receptor radionuclide therapy, and targeted agents, have shown benefits in the treatment of NETs...
November 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29120923/carcinoid-syndrome-recent-advances-current-status-and-controversies
#6
Tetsuhide Ito, Lingaku Lee, Robert T Jensen
PURPOSE OF REVIEW: To review recent advances and controversies in all aspects of carcinoid-syndrome. RECENT FINDINGS: Over the last few years there have been a number of advances in all aspects of carcinoid syndrome as well as new therapies. These include new studies on its epidemiology which demonstrate it is increasing in frequency; increasing insights into the pathogenesis of its various clinical manifestations and into its natural history: definition of prognostic factors; new methods to verify its presence; the development of new drugs to treat its various manifestations, both initially and in somatostatin-refractory cases; and an increased understanding of the pathogenesis, natural history and management of carcinoid heart disease...
November 7, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29110720/first-intraindividual-comparison-of-contrast-enhanced-mri-fet-and-dotatoc-pet-in-patients-with-intracranial-meningiomas
#7
Jan Oliver Dittmar, Clemens Kratochwil, Anne Dittmar, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Frederik L Giesel, Uwe Haberkorn, Jürgen Debus, Stephanie E Combs
BACKGROUND: For irradiation treatment planning of meningiomas the use of PET-scans is well established. The most frequently used tracers are either based on amino acids or the somatostatin receptor ligand DOTATOC. Since up to now no inter-institutionally accepted standard PET-tracer has been defined, the aim of this study was to evaluate the influence of these different types of PET-tracers on the GTV-definition. METHODS: Twenty-one patients suffering from intracranial meningiomas underwent CT, MRI, FET- and DOTATOC-PET...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29108816/obestatin-stimulates-the-somatotrophic-axis-activity-in-sheep
#8
Anna Wójcik-Gładysz, Michał Szlis, Anna Misztal, Bartosz Jarosław Przybył, Jolanta Polkowska
The effects of obestatin (an anorexigenic peripheral peptide) on somatotrophic axis activity in ruminants have not yet been determined. The aim of this study was to investigate the consequence of intracerebroventricular infusions of obestatin on the activity of the somatotrophic axis in peripubertal female sheep. Animals were randomly divided into two groups: control group received intracerebroventricular infusions of the vehicle, and the obestatin group was infused with obestatin (25 µg/120 µL h(-1)). The series of four hourly infusions on three consecutive days were performed...
November 3, 2017: Brain Research
https://www.readbyqxmd.com/read/29105291/enhanced-permeability-and-binding-activity-of-isobutylene-grafted-peptides
#9
Shuang Sun, Ismael Compañón, Nuria Martínez-Sáez, João D Seixas, Omar Boutureira, Francisco Corzana, Gonçalo J L Bernardes
We present a new peptide macrocyclization strategy with an isobutylene graft. The reaction is mild and proceeds rapidly and efficiently both on linear and cyclic peptides. The resulting isobutylene-grafted peptides possess improved passive membrane permeability due to the shielding of the polar backbone of the amides, as demonstrated by NMR and molecular dynamics (MD) simulations. The isobutylene-stapled structures are fully stable in human plasma and in the presence of glutathione. This strategy can be applied to bioactive cyclic peptides such as somatostatin...
November 3, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29104801/childhood-adversities-are-not-a-predictors-of-sstr4met-in-alcoholics
#10
Dominika Berent, Michał Pogórski, Dominika Kulczycka-Wojdala, Ewa Kusideł, Marian Macander, Zofia Pawłowska
Background: Genome methylation may modulate synaptic plasticity, being a potential background for mental disorder. Adverse childhood experiences (ACEs), known to be frequently reported by patients with alcohol dependence (AD), have been proposed as one of environmental inequities influencing DNA methylation. The study is aiming 1.To assess a promoter region methylation in gene for somatostatin receptor subtype-4 (SSTR4), a receptor for somatostatin, a neurotransmitter engaged in neuroplasticity and memory formation, in patients with AD; 2...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/29104610/functional-pancreatic-neuroendocrine-tumour-causing-cushing-s-syndrome-the-effect-of-chemotherapy-on-clinical-symptoms
#11
Paulo Henrique do Amor Divino, Katia Regina Marchetti, Madson Q Almeida, Rachel P Riechelmann
Background: Neuroendocrine tumours (NETs) are a heterogeneous group of diseases that can originate from any part of the gastrointestinal tract, bronchi, thyroid and pancreas. These tumours may be functioning or not depending on their ability to produce active substances, such as adrenocorticotrophic hormone (ACTH). ACTH-producing pancreatic neuroendocrine tumours are rare, with limited data about effective antitumor therapies. Case Report: A 58-year-old man with a history of type-2 diabetes mellitus and arterial hypertension was diagnosed with Cushing's syndrome (CS) secondary to an ACTH ectopic production from a well-differentiated neuroendocrine tumour of the pancreas metastatic to the liver...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104117/characterization-of-somatostatin-receptors-and-associated-signaling-pathways-in-pancreas-of-r6-2-transgenic-mice
#12
Rishi K Somvanshi, Amrit Jhajj, Michael Heer, Ujendra Kumar
The present study describes the status of somatostatin receptors (SSTRs) and their colocalization with insulin (β), glucagon (α) and somatostatin (δ) producing cells in the pancreatic islets of 11weeks old R6/2 Huntington's Disease transgenic (HD tg) and age-matched wild type (wt) mice. We also determined expression of tyrosine hydroxylase (TH), glutamic acid decarboxylase (GAD) and presynaptic marker synaptophysin (SYP) in addition to signal transduction pathways associated with diabetes. In R6/2 mice, islets are relatively smaller in size, exhibit enhanced expression and nuclear inclusion of mHtt along with the loss of insulin, glucagon and somatostatin expression...
November 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29102861/an-isolated-metachronous-metastasis-to-the-adrenal-gland-from-a-pancreatic-neuroendocrine-tumor-a-case-report
#13
Yasunaru Sakuma, Naohiro Sata, Kazuhiro Endo, Yoshikazu Yasuda, Shinichiro Yokota, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyoshi Fukushima, Shoko Asakawa, Yuuki Kawarai Shimada, Chieko Kawarai Lefor, Alan Kawarai Lefor
INTRODUCTION: Pancreatic neuroendocrine tumors are rare. Treatment includes aggressive local management of the primary lesion and metastases, and systemic somatostatin. This is the first report of an isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor that presented 90 months after the primary tumor. PRESENTATION OF CASE: The patient presented as a 53yo man with a left upper quadrant mass and synchronous metastases to the spleen and liver (pancreatic neuroendocrine tumor T4N0M1, Stage IV), which were resected (CD56-, synaptophysin+, chromogranin+, Ki-67<1%)...
October 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29098163/changes-in-somatostatin-like-immunoreactivity-in-the-sympathetic-neurons-projecting-to-the-prepyloric-area-of-the-porcine-stomach-induced-by-selected-pathological-conditions
#14
Katarzyna Palus, Michał Bulc, Jarosław Całka
The aim of the present study was to define changes in the expression of somatostatin (SOM) in the sympathetic perikarya innervating the porcine stomach prepyloric area during acetylsalicylic-acid-induced gastritis (ASA) and experimentally induced hyperacidity (HCL) and following partial stomach resection (RES). On day 1, the stomachs were injected with neuronal retrograde tracer Fast Blue (FB). Animals in the ASA group were given acetylsalicylic acid orally for 21 days. On the 22nd day after FB injection, partial stomach resection was performed in RES animals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29097943/correlation-of-somatostatin-receptor-2-expression-with-gallium-68-dota-tate-uptake-in-neuroblastoma-xenograft-models
#15
Libo Zhang, Douglass C Vines, Deborah A Scollard, Trevor McKee, Teesha Komal, Milan Ganguly, Trevor Do, Bing Wu, Natasha Alexander, Reza Vali, Amer Shammas, Travis Besanger, Sylvain Baruchel
Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as (68)Ga-DOTA-TATE and (177)Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with (68)Ga-DOTA-TATE uptake and (177)Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft models. We demonstrated variable SSTR2 expression profiles in eight NB cell lines. From micro-PET imaging and autoradiography, a higher uptake of (68)Ga-DOTA-TATE was observed in SSTR2 high-expressing NB xenografts (CHLA-15) compared to SSTR2 low-expressing NB xenografts (SK-N-BE(2))...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29082242/colonic-transit-time-and-gut-peptides-in-adult-patients-with-slow-and-normal-colonic-transit-constipation
#16
Giuseppe Riezzo, Guglielmina Chimienti, Caterina Clemente, Benedetta D'Attoma, Antonella Orlando, Caterina Mammone Rinaldi, Francesco Russo
PURPOSE: To investigate whether pathophysiological differences exist among healthy controls (HC) and patients with slow and normal transit constipation (STC and NTC), we evaluated (1) gastrointestinal (GI) symptoms using validated questionnaires; (2) circulating concentrations of neurotensin, motilin, corticotrophin-releasing factor (CRF), and somatostatin; and (3) possible differences in frequency distribution of the neurotensin rs1800832 A/G and Neurotensin Receptor 1 rs6090453 C/G SNPs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29081664/impact-of-prior-therapies-on-everolimus-activity-an-exploratory-analysis-of-radiant-4
#17
Roberto Buzzoni, Carlo Carnaghi, Jonathan Strosberg, Nicola Fazio, Simron Singh, Fabian Herbst, Antonia Ridolfi, Marianne E Pavel, Edward M Wolin, Juan W Valle, Do-Youn Oh, James C Yao, Rodney Pommier
BACKGROUND: Recently, everolimus was shown to improve median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of lung or gastrointestinal (GI) tract compared with placebo (HR, 0.48; 95% CI, 0.35-0.67; P<0.00001) in the Phase III, RADIANT-4 study. This post hoc analysis evaluates the impact of prior therapies (somatostatin analogs [SSA], chemotherapy, and radiotherapy) on everolimus activity...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29080965/how-to-improve-effectiveness-of-pegvisomant-treatment-in-acromegalic-patients
#18
M Ragonese, S Grottoli, P Maffei, A Alibrandi, M R Ambrosio, G Arnaldi, A Bianchi, S Puglisi, M C Zatelli, L De Marinis, E Ghigo, A Giustina, F Maffezzoni, C Martini, L Trementino, S Cannavo
PURPOSE: Pegvisomant (PEGV) treatment in acromegaly patients resistant to somatostatin analogues is less effective in the real life than in clinical trials. This is a multicenter, observational, retrospective, longitudinal study. The aim was to detect characteristics which improve long-term PEGV effectiveness. METHODS: 87 acromegalic patients treated with PEGV have been enrolled in seven referral Italian centres. PEGV was administered for up to 4 years, at doses up titrated until IGF-1 normalization or to ≥ 30 mg/day...
October 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29080025/early-postnatal-development-of-somastostatinergic-systems-in-brainstem-respiratory-network
#19
Isabel Llona, Paula Farías, Jennifer L Troc-Gajardo
Somatostatin is a peptide able to stop breathing, acting in the neural network that generates and control the respiratory rhythm. In this chapter, we present data on the early postnatal development of somatostatinergic systems in the mouse brainstem and summarize evidence for their influence on the generation and control of the respiratory rhythm.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29076910/optimizing-somatostatin-receptor-imaging-in-patients-with-neuroendocrine-tumors-the-impact-of-99mtc-hynictoc-spect-spect-ct-versus-68ga-dotatate-pet-ct-upon-clinical-management
#20
Jolanta Kunikowska, Valerie Lewington, Leszek Krolicki
AIM: The presence of somatostatin receptors in neuroendocrine tumors allows visualization with radiolabeled somatostatin analogs in vivo. The aim of this prospective study was to compare somatostatin receptor imaging using Tc-HYNICTOC with Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) with respect to sensitivity, specificity, and impact upon clinical decision making. METHODS: Sixty-eight patients (30 men, 38 women; aged 56.4 ± 13.5 years) with disseminated, histologically proven neuroendocrine tumor were enrolled...
December 2017: Clinical Nuclear Medicine
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