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interleukin 8, term labour

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https://www.readbyqxmd.com/read/27780541/atf3-is-a-negative-regulator-of-inflammation-in-human-fetal-membranes
#1
Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas
INTRODUCTION: Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9, which play a central role in myometrial contractions and rupture of fetal membranes. In human and mouse immune cells, activating transcription factor 3 (ATF3) is a negative regulator of inflammation. No studies have examined the role of ATF3 in human labour. METHODS: Primary amnion cells were used to determine the effect of interleukin (IL)-1β and the bacterial product fibroblast-stimulating lipopeptide (fsl-1) on ATF3 expression, and the effect of ATF3 siRNA on pro-labour mediators...
November 2016: Placenta
https://www.readbyqxmd.com/read/26733542/copper-metabolism-domain-containing-1-represses-the-mediators-involved-in-the-terminal-effector-pathways-of-human-labour-and-delivery
#2
Martha Lappas
STUDY HYPOTHESIS: Does Copper Metabolism MURR1 Domain 1 (COMMD1) play a role in regulating the mediators involved in the terminal processes of human labour and delivery? STUDY FINDING: COMMD1 plays a critical role in the termination of nuclear factor-κB (NF-κB) activity and the control of pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Inflammation and infection are the biggest aetiological factors associated with preterm birth...
April 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/25965269/inflammatory-signalling-in-fetal-membranes-increased-expression-levels-of-tlr-1-in-the-presence-of-preterm-histological-chorioamnionitis
#3
Gareth J Waring, Stephen C Robson, Judith N Bulmer, Alison J Tyson-Capper
Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause of preterm birth. No studies have characterised the global change in expression of genes involved in the toll-like receptor (TLR) signalling pathways in the presence of HCA in the setting of preterm birth (pHCA). Fetal membranes were collected immediately after delivery and underwent histological staging for inflammation to derive 3 groups; term spontaneous labour without HCA (n = 9), preterm birth <34 weeks gestation without HCA (n = 8) and pHCA <34 weeks (n = 12)...
2015: PloS One
https://www.readbyqxmd.com/read/25048443/prostaglandin-pathway-gene-expression-in-human-placenta-amnion-and-choriodecidua-is-differentially-affected-by-preterm-and-term-labour-and-by-uterine-inflammation
#4
Robert J Phillips, Michel A Fortier, Andrés López Bernal
BACKGROUND: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term induction. Prostaglandins act at all stages of human reproduction, and are potentially activators of labour. METHODS: Expression of 15 genes involved in prostaglandin synthesis, transport and degradation was measured by qPCR using tissue samples from human placenta, amnion and choriodecidua at preterm and full-term vaginal and caesarean delivery...
July 22, 2014: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/24693199/cancer-incidence-and-novel-therapies-developed-in-japan
#5
M Iwasaki
According to the ministry of Health, Labour and welfare of Japan, Cancer has been the leading cause of death in Japan since 1981. ([1]) As per the data in 2010, in Japan, one in every three deaths was due to cancer. ([2]) The Japanese Government has introduced so far, three terms of 10 years strategies for Cancer control since 1984 till date. The budget allocated for cancer control in 2009 was 52.5 billion yen in Japan. ([3]) Lung is the leading site for cancer in both males and females in Japan. In males, following the lung, stomach, liver, colon and pancreas are other leading sites while in the females, stomach, colon, pancreas and breast are the other leading sites...
2012: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/23778262/forkhead-box-o1-foxo1-in-pregnant-human-myometrial-cells-a-role-as-a-pro-inflammatory-mediator-in-human-parturition
#6
Martha Lappas
Prematurity is the most important complication contributing to neonatal morbidity and mortality. It is the untimely activation of the terminal events of human parturition that lead to preterm birth, with inflammation playing a driving role in initiating uterine contractions. The purpose of this study was to investigate the role of Forkhead box O1 (FOXO1), a pro-inflammatory modulator, during human parturition. FOXO1 mRNA expression was quantified using qRT-PCR, and protein expression using Western blotting in myometrial biopsies from pregnant non-labouring and labouring women at term...
September 2013: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/23445904/development-and-validation-of-primary-human-myometrial-cell-culture-models-to-study-pregnancy-and-labour
#7
Andrea A Mosher, Kelly J Rainey, Seunghwa S Bolstad, Stephen J Lye, Bryan F Mitchell, David M Olson, Stephen L Wood, Donna M Slater
BACKGROUND: The development of the in vitro cell culture model has greatly facilitated the ability to study gene expression and regulation within human tissues. Within the human uterus, the upper (fundal) segment and the lower segment may provide distinct functions throughout pregnancy and during labour. We have established primary cultured human myometrial cells, isolated from both upper and lower segment regions of the pregnant human uterus, and validated them for the purpose of studying human pregnancy and labour...
2013: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/22729138/labour-induction-at-term-clinical-biophysical-and-molecular-predictive-factors
#8
MULTICENTER STUDY
Francesca Riboni, Greta Garofalo, Irene Pascoli, Anna Vitulo, Marinella Dell'avanzo, Giuseppe Battagliarin, Delia Paternoster
PURPOSE: The aim of this multicentric study is to compare clinical, biophysical and molecular parameters in the prediction of the success of labour induction with prostaglandins. METHODS: We included 115 women, who underwent to labour induction at term with vaginal prostaglandin gel. We evaluated the diagnostic efficiency of endocervical phosphorylated insulin-like growth factor-binding protein (phIGFBP-1), cervicovaginal interleukins 6 (IL-6) and 8 (IL-8). We analyzed the transvaginal sonographic measurement of cervical length...
November 2012: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/22685373/nf%C3%AE%C2%BAb-and-ap-1-drive-human-myometrial-il8-expression
#9
Shirin Khanjani, Vasso Terzidou, Mark R Johnson, Phillip R Bennett
The uterine expression of the chemokine IL8 increases dramatically with the onset of labour both at term and preterm. The IL8 promoter contains binding sites for the transcription factors nuclear factor-kappa B (NFκB), activator protein-1 (AP-1), and CCAAT/enhancer-binding protein (CEBP). In this study we investigated the roles of these transcription factors in IL1B regulation of the IL8 gene in human myometrium. Using chromatin immune precipitation (ChIP) assay, we showed that each of NFκB, CEBP, and AP-1 binds to the IL8 promoter upon IL1B stimulation...
2012: Mediators of Inflammation
https://www.readbyqxmd.com/read/22341631/changes-in-placental-progesterone-receptors-in-term-and-preterm-labour
#10
E Zachariades, D Mparmpakas, Y Pang, M Rand-Weaver, P Thomas, E Karteris
Currently, preterm labour is associated with increased fetal mortality and morbidity and is often associated with elevated levels of inflammatory cytokines. However, the exact mechanisms that lead to this pathology are not fully elucidated. In the present study evidence was obtained using a specific membrane progesterone receptor (mPR) agonist, Org OD 02-0, that the progestin antagonism of apoptotic effects of a cytokine, IL-1β, on human placental BeWo cells is mediated through mPRs. Therefore the aim of this study was to determine whether the gene expression of mPRs and all other known progesterone receptors changes in human placentas at term and during labour...
May 2012: Placenta
https://www.readbyqxmd.com/read/22319205/nuclear-factor-%C3%AE%C2%BAb-mediates-placental-growth-factor-induced-pro-labour-mediators-in-human-placenta
#11
Martha Lappas
Prostaglandins, pro-inflammatory cytokines, extracellular matrix remodelling enzymes and nuclear factor-kappa B (NF-κB) are involved in the mechanisms of term and preterm parturition. Recent studies have reported an increase in angiogenesis-related genes during term and preterm labour, including placental growth factor (PLGF). In non-gestational tissues, PLGF induces inflammation via NF-κB. The aim of this study was to determine the effect of PLGF on the gene expression and release of pro-labour mediators in human placenta...
July 2012: Molecular Human Reproduction
https://www.readbyqxmd.com/read/21839801/visfatin-regulates-the-terminal-processes-of-human-labour-and-delivery-via-activation-of-the-nuclear-factor-%C3%AE%C2%BAb-pathway
#12
Martha Lappas
The inflammatory process plays a pivotal role during the pathogenesis of human labour, both at term and preterm. Visfatin levels increase during normal human pregnancy and in infection associated preterm labour. The effects of visfatin in the processes of human labour and delivery, however, are not known. The aim of this study was to determine the effect of visfatin on the expression and release of pro-labour mediators in human placenta. Samples were obtained from normal pregnancies at the time of Caesarean section...
January 2, 2012: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/21414766/the-anti-inflammatory-and-antioxidative-effects-of-nicotinamide-a-vitamin-b-3-derivative-are-elicited-by-foxo3-in-human-gestational-tissues-implications-for-preterm-birth
#13
Martha Lappas, Michael Permezel
The inflammatory process plays a pivotal role during the pathogenesis of human labour, both at term and at preterm. Nicotinamide, a vitamin B(3) derivative, exerts anti-inflammatory and antioxidative properties in several cell types by interaction with various intracellular signalling proteins via modulating the activity of various transcription factors, including activation of the O subfamily of Forkhead/winged helix transcription factors (FoxO) and inhibition of nuclear factor-κB (NF-κB). The aim of this study was to determine the effect of nicotinamide on the expression of pro-labour and mediators in human placenta...
December 2011: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/21294128/chronic-chorioamnionitis-displays-distinct-alterations-of-the-amniotic-fluid-proteome
#14
Giovanna Oggé, Roberto Romero, Deug-Chan Lee, Francesca Gotsch, Nandor Gabor Than, Joonho Lee, Tinnakorn Chaiworapongsa, Zhong Dong, Pooja Mittal, Sonia S Hassan, Chong Jai Kim
Acute chorioamnionitis of infectious origin and chronic chorioamnionitis of immunological origin are two major placental lesions of spontaneous preterm birth with elevated amniotic fluid interleukin-6 and CXCL10 concentrations, respectively. The changes in the amniotic fluid proteome associated with intra-amniotic infection and acute chorioamnionitis are well defined, yet alterations unique to chronic chorioamnionitis remain to be elucidated. This study was conducted to determine those amniotic fluid proteins changing specifically in the presence of chronic chorioamnionitis...
March 2011: Journal of Pathology
https://www.readbyqxmd.com/read/20515822/effects-of-epidural-and-systemic-maternal-analgesia-in-term-infants-the-nopil-study
#15
Carlo Dani, Silvia Perugi, Giulia Fontanelli, Giovanna Bertini, Simone Pratesi, Giuseppe Buonocore, Mariangela Longini, Fabrizio Proietti, Cosetta Felici, Riccardo Ciuti, Paola D'Onofrio, Annamaria Melani Novelli, Marco Pezzati, Davide Gambi, Gianfranco Scarselli, Alessandro Frigiola, Alessandro Giamberti, Raul Abella, Firmino F Rubaltelli
The aim of the No Pain in Labour (NoPiL) study was to evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, beta-endorphin, oxidative stress markers (ie: total hydroperoxide (TH) and advanced oxidation protein products (AOPP)), interleukin-1beta (IL-1beta), and interleukin-8 (IL-8) cytokines were measured in arterial cord blood samples...
2010: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/19969371/a-role-for-il-17-in-induction-of-an-inflammation-at-the-fetomaternal-interface-in-preterm-labour
#16
Mika Ito, Akitoshi Nakashima, Takao Hidaka, Motonori Okabe, Nguyen Duy Bac, Shihomi Ina, Satoshi Yoneda, Arihiro Shiozaki, Shigeki Sumi, Koichi Tsuneyama, Toshio Nikaido, Shigeru Saito
Chorioamnionitis (CAM) is a major cause of preterm delivery. Inflammatory cytokines and chemokines play important roles in the pathogenesis of preterm delivery. Interleukin (IL)-17 is a key cytokine which induces inflammation and is critical to host defense. In this study, we examined the role of IL-17 in the pathogenesis of preterm delivery. The levels of cytokines including IL-17, IL-8 and tumor necrosis factor (TNF) alpha were measured by ELISA in amniotic fluid from 154 cases of preterm labor. Flow cytometry and immunohistochemical staining were performed to determine the distribution of IL-17-producing cells...
January 2010: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/19338208/-selected-cytokine-gene-polymorphisms-and-the-risk-of-preterm-delivery-in-the-population-of-polish-women
#17
Jarosław Kalinka, Adam Bitner
OBJECTIVE: Recent studies suggest that preterm delivery might be conditioned genetically. The main aim of this study was to examine the relationship between spontaneous preterm delivery (PTD) and the carriage of polymorphic genes that code the following cytokines: interleukin-1beta [IL1beta (+3953C>T)], interleukin-6 promoter [IL6 (-174G>C)], tumour necrosis factor-alpha promoter [TNFalpha (-308G>A)] and interleukin-1 receptor antagonist (IL1RN) in the population of Polish women...
February 2009: Ginekologia Polska
https://www.readbyqxmd.com/read/18550178/inflammatory-processes-in-preterm-and-term-parturition
#18
REVIEW
Inge Christiaens, Dean B Zaragoza, Larry Guilbert, Sarah A Robertson, Bryan F Mitchell, David M Olson
A role for the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, IL-8 and tumor necrosis factor alpha (TNF-alpha) is evident in term and preterm delivery, and this is independent of the presence of infection. All uterine tissues progress through a staged transformation near the end of pregnancy that leads from relative uterine quiescence and maintenance of pregnancy to the activation of the uterus that prepares it for the work of labour and production of stimulatory molecules that trigger the onset of labour and delivery...
October 2008: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/18367515/pro-labour-myometrial-gene-expression-are-preterm-labour-and-term-labour-the-same
#19
COMPARATIVE STUDY
Mark Tattersall, Neelam Engineer, Shirin Khanjani, Suren R Sooranna, Victoria H Roberts, Peta L Grigsby, Zhiqing Liang, Les Myatt, Mark R Johnson
Preterm labour (PTL) is the most important cause of neonatal morbidity and mortality. While some causes have been identified, the mechanisms involved remain elusive. This study investigates whether term labour (TL) is an appropriate model for PTL by examining pro-labour gene expression, using quantitative rtPCR, and protein synthesis, using Western analysis, in preterm and term myometrial samples obtained from the upper and lower uterine segments before and after the onset of labour. In the lower segment, the levels of prostaglandin H synthase type-2 (PGHS-2), interleukin-1beta (IL-1beta), IL-6 and IL-8 mRNA expression were significantly higher in TL compared with PTL samples...
April 2008: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/16935997/myometrial-prostaglandin-e2-synthetic-enzyme-mrna-expression-spatial-and-temporal-variations-with-pregnancy-and-labour
#20
COMPARATIVE STUDY
S R Sooranna, P L Grigsby, N Engineer, Z Liang, K Sun, L Myatt, M R Johnson
We have investigated the hypothesis that the expression of the enzymes involved in PGE(2) synthesis in the human uterus is co-ordinated. We have studied (i) the mRNA expression of the enzymes involved in PGE(2) synthesis [phospholipases (cPLA(2) and sPLA(2)), prostaglandin H synthase (PGHS)-2 and PG E synthases (PGES-1 and -2)] and their relationship to the expression of inflammatory cytokines in samples of myometrium obtained from pregnant women undergoing caesarean section (LSCS) either before or after the onset of labour at or before term; and (ii) the effect of IL-1beta, IL-6, TNF-alpha, PGE(2) and stretch on PGE(2) enzyme mRNA expression...
October 2006: Molecular Human Reproduction
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