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Brandy E Wade, Jingru Zhao, Jing Ma, C Michael Hart, Roy L Sutliff
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
Jordana E Hoppe, Brandie D Wagner, Frank J Accurso, Edith T Zemanick, Scott D Sagel
BACKGROUND: Pulmonary exacerbations (PEx) in children with cystic fibrosis (CF) are frequently treated in the outpatient setting with oral antibiotics. However, little is known about the characteristics of PEx managed on an outpatient basis and the effectiveness of oral antibiotic therapy. We sought to prospectively evaluate clinical and laboratory changes associated with oral antibiotic treatment for PEx. METHODS: Children with CF between 8 and 18 years of age prescribed two weeks of oral antibiotics for a PEx were eligible to enroll...
June 16, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Brandi M Heckel, David Eshar, Kelli M Almes
Because black-tailed prairie dogs (Cynomys ludovicianus) are used as a model for research on gallstones and bacterial infections, performing urinary evaluations can provide invaluable data. This case report involves 5 prairie dogs that developed moist necrotic skin lesions after urine collection by cystocentesis. The information presented here serves as a resource regarding a potential adverse event that may develop after cystocentesis in black-tailed prairie dogs.
June 1, 2018: Comparative Medicine
Xi Chen, Yannan Zhao, Xing Li, Zhifeng Xiao, Yuanjiang Yao, Yun Chu, Balázs Farkas, Ilaria Romano, Fernando Brandi, Jianwu Dai
Many factors contribute to the poor axonal regrowth and ineffective functional recovery after spinal cord injury (SCI). Biomaterials have been used for SCI repair by promoting bridge formation and reconnecting the neural tissue at the lesion site. The mechanical properties of biomaterials are critical for successful design to ensure the stable support as soon as possible when compressed by the surrounding spine and musculature. Poly(propylene fumarate) (PPF) scaffolds with high mechanical strength have been shown to provide firm spatial maintenance and to promote repair of tissue defects...
June 19, 2018: Advanced Healthcare Materials
Jock C Lillard, Garrett T Venable, Nickalus R Khan, Ruth G Tatevossian, James Dalton, Brandy N Vaughn, Paul Klimo
BACKGROUND: Pediatric supratentorial ependymomas (SEs) have distinct molecular and behavioral differences from their infratentorial counterparts. OBJECTIVE: To present our experience with pediatric SEs over a 24-yr period. METHODS: Clinical, operative, and radiographic information was abstracted retrospectively. Our primary outcomes were progression-free survival (PFS) and overall survival (OS). Detection of C11orf95-RELA rearrangement was performed using interphase fluorescence in situ hybridization (iFISH)...
June 16, 2018: Neurosurgery
Julian M Dymacek, Brandi N Snyder-Talkington, Rebecca Raese, Chunlin Dong, Salvi Singh, Dale W Porter, Barbara Ducatman, Michael G Wolfarth, Michal E Andrew, Lori Battelli, Vincent Castranova, Yong Qian, Nancy L Guo
Respiratory exposure to multiwalled carbon nanotubes (MWCNT) or asbestos results in fibrosis; however, the mechanisms to reach this end point may be different. A previous study by our group identified pulmonary effects and significantly altered messenger RNA (mRNA) signaling pathways following exposure to 1, 10, 40, and 80 µg MWCNT and 120 µg crocidolite asbestos on mouse lungs over time at 1-month, 6-month, and 1-year postexposure following pulmonary aspiration. As a continuation to the above study, this current study took an in-depth look at the signaling pathways involved in fibrosis development at a single time point, 1 year, and exposure, 40 µg MWCNT, the lowest exposure at which fibrosis was pathologically evident...
January 1, 2018: International Journal of Toxicology
Martina T Ayad, Brandie D Taylor, Ramkumar Menon
PROBLEM: Oxidative stress (OS)-induced, p38 mitogen-activated protein kinase (p38MAPK)-mediated chorioamniotic senescence and inflammation (senescence-associated secretory phenotype [SASP]) are associated with parturition. In response to OS-inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK-mediated senescence and SASP...
June 17, 2018: American Journal of Reproductive Immunology: AJRI
Brandy A Briones, Vincent D Tang, Amanda E Haye, Elizabeth Gould
Increases in the number and/or the size of dendritic spines, sites of excitatory synapses, have been linked to different types of learning as well as synaptic plasticity in several brain regions, including the hippocampus, sensory cortex, motor cortex, and cerebellum. By contrast, a previous study reported that training on a maze task that requires the dorsal striatum has no effect on medium spiny neuron dendritic spines in the dorsal striatum. These findings might suggest brain region-specific differences in levels of plasticity as well as different cellular processes underlying different types of learning...
June 14, 2018: Neurobiology of Learning and Memory
Megan N Huizenga, Brandy E Fureman, Ivan Soltesz, Nephi Stella
No abstract text is available yet for this article.
June 14, 2018: Epilepsy & Behavior: E&B
Shane Jacobeen, Elyes C Graba, Colin G Brandys, Thomas C Day, William C Ratcliff, Peter J Yunker
The evolutionary transition to multicellularity transformed life on earth, heralding the evolution of large, complex organisms. Recent experiments demonstrated that laboratory-evolved multicellular "snowflake yeast" readily overcome the physical barriers that limit cluster size by modifying cellular geometry [Jacobeen et al., Nat. Phys. 14, 286 (2018)10.1038/s41567-017-0002-y]. However, it is unclear why this route to large size is observed, rather than an evolved increase in intercellular bond strength...
May 2018: Physical Review. E
Colette Nickodem, Michael F Criscitiello, Fuller Bazer, Olayinka Abiodun-Ojo, Brandie D Taylor
PROBLEM: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. METHOD OF STUDY: Vaginal or cervical specimens from 30 pregnant women were obtained from the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) repository...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
Brandy Schillace
No abstract text is available yet for this article.
June 2018: Medical Humanities
Joseph J Pariser, Omar E Soto-Aviles, Brandi Miller, Maha Husainat, Richard A Santucci
OBJECTIVES: To propose a simple classification system for buried penis repairs and present an analysis of perioperative data based on category. METHODS: Patients undergoing buried penis repair at a single institution were examined. Classification was as follows: Category I - Penile Unburying with Local Flap; II - Skin Graft; III - Scrotal Surgery; IV - Escutcheonectomy; V - Abdominal Panniculectomy. Complex repairs were Category III or above. Success was defined as an unburied penis without additional unburying surgery...
June 10, 2018: Urology
Donn J Colby, Lydie Trautmann, Suteeraporn Pinyakorn, Louise Leyre, Amélie Pagliuzza, Eugène Kroon, Morgane Rolland, Hiroshi Takata, Supranee Buranapraditkun, Jintana Intasan, Nitiya Chomchey, Roshell Muir, Elias K Haddad, Sodsai Tovanabutra, Sasiwimol Ubolyam, Diane L Bolton, Brandie A Fullmer, Robert J Gorelick, Lawrence Fox, Trevor A Crowell, Rapee Trichavaroj, Robert O'Connell, Nicolas Chomont, Jerome H Kim, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
June 11, 2018: Nature Medicine
Giosuè Annibalini, Serena Contarelli, Mauro De Santi, Roberta Saltarelli, Laura Di Patria, Michele Guescini, Anna Villarini, Giorgio Brandi, Vilberto Stocchi, Elena Barbieri
Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These proIGF-1s have a common IGF-1 mature sequence but different E-domains. The structure of the E-domains has not been resolved, and their molecular functions are still unclear. Here, we show that E-domains are Intrinsically Disordered Regions that have distinct regulatory functions on proIGF-1s production...
June 11, 2018: Scientific Reports
Elizabeth K K Glennon, Dewi Megawati, Brandi K Torrevillas, Isaac Ssewanyana, Liusheng Huang, Fran Aweeka, Bryan Greenhouse, L Garry Adams, Shirley Luckhart
Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite transmission to mosquitoes. Here, we report that higher circulating ABA levels were associated with a reduced risk of symptomatic malaria in a cohort of Plasmodium falciparum-infected Ugandan children...
June 11, 2018: Scientific Reports
Brandy A Wicklow, Elizabeth A C Sellers, Atul K Sharma, Kristine Kroeker, Nathan C Nickel, Wanda Philips-Beck, Garry X Shen
Importance: Type 2 diabetes is increasing worldwide, disproportionately affecting First Nations (FN) people. Identifying early-life determinants of type 2 diabetes is important to address the intergenerational burden of illness. Objective: To investigate the association of in utero exposure to gestational diabetes and type 2 diabetes, stratified by FN status, with the development of type 2 diabetes in offspring. Design, Setting, and Participants: This cohort study was derived from the linkage of a pediatric diabetes clinical database and a population-based research data repository in Manitoba, Canada...
June 11, 2018: JAMA Pediatrics
Marquis Philip Vawter, Robert Philibert, Brandi Rollins, Patricia L Ruppel, Terry W Osborn
This study developed potential blood-based biomarker tests for diagnosing and differentiating schizophrenia (SZ), bipolar disorder type I (BD), and normal control (NC) subjects using mRNA gene expression signatures. A total of 90 subjects ( n = 30 each for the three groups of subjects) provided blood samples at two visits. The Affymetrix exon microarray was used to profile the expression of over 1.4 million probesets. We selected potential biomarker panels using the temporal stability of the probesets and also back-tested them at two different visits for each subject...
May 2018: Molecular Neuropsychiatry
William R Dardick, Brandi A Weiss
This article introduces three new variants of entropy to detect person misfit ( Ei , EMi , and EMRi ), and provides preliminary evidence that these measures are worthy of further investigation. Previously, entropy has been used as a measure of approximate data-model fit to quantify how well individuals are classified into latent classes, and to quantify the quality of classification and separation between groups in logistic regression models. In the current study, entropy is explored through conceptual examples and Monte Carlo simulation comparing entropy with established measures of person fit in item response theory (IRT) such as lz , lz *, U , and W ...
October 2017: Applied Psychological Measurement
Jeanette M Daly, Raul Calderon, Daniel J Hoffman-Zinnel, Laura A Wynohrad, Brandy N Powers, Tami L Mohr, Barcey T Levy
Cancer prevention efforts at the community level are essential in the fight against cancer. Understanding community dynamics provides insights into building meaningful relationships between researchers and community organizations. In this study, community assistants were hired to organize and host forums to encourage interdisciplinary collaboration, with the goal of strengthening and transforming relationships between a university academic health center and communities. A 19-item questionnaire was developed to determine the strategies community assistants used to schedule and host community forums...
June 6, 2018: European Journal of Cancer Care
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