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https://www.readbyqxmd.com/read/29034056/effects-of-sterilization-on-shape-memory-polyurethane-embolic-foam-devices
#1
Rachael Muschalek, Landon Nash, Ryan Jones, Sayyeda M Hasan, Brandis K Keller, Mary Beth B Monroe, Duncan J Maitland
Polyurethane shape memory polymer (SMP) foams have been developed for various embolic medical devices due to their unique properties in minimally invasive biomedical applications. These polyurethane materials can be stored in a secondary shape, from which they can recover their primary shape after exposure to an external stimulus, such as heat and water exposure. Tailored actuation temperatures of SMPs provide benefits for minimally invasive biomedical applications, but incur significant challenges for SMP-based medical device sterilization...
September 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29029997/correlation-of-general-and-oral-health-related-quality-of-life-in-malocclusion-patients-treated-with-a-combined-orthodontic-and-maxillofacial-surgical-approach
#2
Johannes Alexander Tamme, Michael Rohnen, Volker Gaßling, Robert Ciesielski, Helge Fischer-Brandies, Jörg Wiltfang, Bernd Koos
PURPOSE: The aim of the study was to collect information about the oral health-related quality of life (OHRQoL) after combined orthodontic and maxillofacial surgical treatment as well as its influence on health-related quality of life (HRQoL). MATERIALS AND METHODS: The study includes data from a total of 130 subjects, 65 of whom (21 male, 44 female, mean age at baseline: 24 years, mean age at the time of surgery: 26 years) were compared with control subjects matched on the basis of gender and age...
August 31, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29029919/the-doll-hairline-a-clue-for-the-diagnosis-of-frontal-fibrosing-alopecia
#3
Nicolò Brandi, Michela Starace, Aurora Alessandrini, Francesca Bruni, Bianca Maria Piraccini
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29024931/brain-metastases-from-biliary-tract-cancer-a-monocentric-retrospective-analysis-of-450-patients
#4
Giorgio Frega, Ingrid Garajová, Andrea Palloni, Maria Aurelia Barbera, Marco Trossello Pastore, Luca Faccioli, Luca Spinardi, Stefania De Lorenzo, Marta Cubelli, Maria Abbondanza Pantaleo, Guido Biasco, Giovanni Brandi
OBJECTIVE: Brain metastases (BMs) from biliary tract cancer (BTC) are extremely rare. The aim of our study was to report the incidence of BMs in patients with BTC. METHODS: We retrospectively analyzed a series of 450 patients with BTC. Presence of brain lesions was investigated only when symptoms were evident. Cumulative incidence, median overall survival (OS) from detection of BMs, median OS from cancer diagnosis, and median time from cancer diagnosis to detection of BMs were evaluated...
October 13, 2017: Oncology
https://www.readbyqxmd.com/read/29024808/critical-care-nurses-experiences-of-withdrawal-of-treatment-a-systematic-review-of-qualitative-evidence
#5
REVIEW
Brandi Vanderspank-Wright, Nikolaos Efstathiou, Amanda D Vandyk
BACKGROUND: Death and dying is a reality of the clinical context of the intensive care unit. Death often follows a decision to withdraw life-sustaining treatments. Critical care nurses, are the primary care providers to patients and families at the end-of-life in the intensive care unit. OBJECTIVE: To synthesize qualitative evidence on the experiences of critical care nurses who have cared for patients and families throughout the process of withdrawal of life-sustaining treatment...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29022895/impairment-of-ptx3-expression-in-osteoblasts-a-key-element-for-osteoporosis
#6
Manuel Scimeca, Antonietta Salustri, Elena Bonanno, Daniela Nardozi, Cecilia Rao, Eleonora Piccirilli, Maurizio Feola, Virginia Tancredi, Annamaria Rinaldi, Giovanni Iolascon, Augusto Orlandi, Elena Gasbarra, Nicola Maffulli, Maria Luisa Brandi, Umberto Tarantino
Pentraxin 3 (PTX3) is a multifunctional glycoprotein regulating inflammatory response, cell proliferation and migration and deposition and remodelling of the extracellular matrix by a variety of cells. In this study, we investigated the possible role of PTX3 in bone homeostasis. To this end, we compared the expression and function of PTX3 in human osteoblasts of osteoporotic, osteoarthritic patients and young subjects not affected by bone diseases. Immunohistochemical analysis performed on bone head biopsies showed a close association between bone health and the number of osteoblasts expressing PTX3...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020329/vitamin-d3-supplementation-increases-spine-bone-mineral-density-in-adolescents-and-young-adults-with-hiv-infection-being-treated-with-tenofovir-disoproxil-fumarate-a-randomized-placebo-controlled-trial
#7
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, D Robert Harris, Georgine Price, Alyne Baker, William A Meyer, Craig M Wilson, Rohan Hazra, Bill G Kapogiannis, Kathleen Mulligan
Background: Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized vitamin D3 (VITD3) would increase BMD in youth receiving TDF. Methods: Randomized double-blind placebo-controlled trial of directly observed VITD3 vs. placebo every 4 weeks for 48 weeks in youth ages 16-24 years with HIV, viral load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N=214) received a daily multivitamin containing VITD3 400 IU and calcium 162 mg, plus monthly randomized VITD3 50,000 IU (N=109) or placebo (N=105)...
August 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019160/the-role-of-cognitive-reserve-in-cognitive-aging-what-we-can-learn-from-parkinson-s-disease
#8
Nicoletta Ciccarelli, Maria Rita Lo Monaco, Domenico Fusco, Davide Liborio Vetrano, Giuseppe Zuccalà, Roberto Bernabei, Vincenzo Brandi, Maria Stella Pisciotta, Maria Caterina Silveri
Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29016551/pectoral-fascial-pecs-i-and-ii-blocks-as-rescue-analgesia-in-a-patient-undergoing-minimally-invasive-cardiac-surgery
#9
Suraj Yalamuri, Rebecca Y Klinger, W Michael Bullock, Donald D Glower, Brandi A Bottiger, Jeffrey C Gadsden
INTRODUCTION: Patients undergoing minimally invasive cardiac surgery have the potential for significant pain from the thoracotomy site. We report the successful use of pectoral nerve block types I and II (Pecs I and II) as rescue analgesia in a patient undergoing minimally invasive mitral valve repair. CASE REPORT: In this case, a 78-year-old man, with no history of chronic pain, underwent mitral valve repair via right anterior thoracotomy for severe mitral regurgitation...
October 6, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28990404/dietary-planning-self-efficacy-and-outcome-expectancies-play-a-role-in-an-online-intervention-on-fruit-and-vegetable-consumption
#10
Ralf Schwarzer, Lisa M Warner, Lena Fleig, Maryam Gholami, Lluis Serra-Majem, Joy Ngo, Luisella Cianferotti, Maria Kritikou, Piergiorgio Mossi, Evangelia Ntzani, Maria L Brandi
OBJECTIVE: An online intervention to improve fruit and vegetable (FV) intake examines the role of planning, outcome expectancies, self-efficacy and gender. Women are not only expected to eat more FV than men, but they are also expected to be more responsive to nutritional advice and benefit more from treatment. METHOD: A two-arm digital intervention with 269 men and 395 women (Mage = 41.2, SDage = 11.45; range: 19-66 years) was conducted in Italy, Spain and Greece, followed up at three and six months, comparing a static with a dynamic, feedback-intensive platform...
October 9, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28989267/the-impact-of-transcription-writing-interventions-for-first-grade-students
#11
Jeanne Wanzek, Brandy Gatlin, Stephanie Al Otaiba, Young-Suk Grace Kim
We examined the effects of transcription instruction for students in first grade. Students in the lowest 70% of the participating schools were selected for the study. These 81 students were randomly assigned to: (a) spelling instruction, (b) handwriting instruction, (c) combination spelling and handwriting instruction, or (d) no intervention. Intervention was provided in small groups of 4 students, 25 min a day, 4 days a week for 8 weeks. Students in the spelling condition outperformed the control group on spelling measures with moderate effect sizes noted on curriculum-based writing measures (e...
2017: Reading & Writing Quarterly: Overcoming Learning Difficulties
https://www.readbyqxmd.com/read/28988289/whole-body-magnetic-resonance-imaging-wb-mri-and-brain-mri-baseline-surveillance-in-tp53-germline-mutation-carriers-experience-from-the-li-fraumeni-syndrome-education-and-early-detection-lead-clinic
#12
Jasmina Bojadzieva, Behrang Amini, Suzanne F Day, Tiffiny L Jackson, Parijatham S Thomas, Brandy J Willis, Whitney R Throckmorton, Najat C Daw, Therese B Bevers, Louise C Strong
Individuals with Li-Fraumeni syndrome (LFS) have a significantly increased lifetime cancer risk affecting multiple organ sites. Therefore, novel comprehensive screening approaches are necessary to improve cancer detection and survival in this population. The objective of this study was to determine the diagnostic performance of whole body MRI (WB-MRI) and dedicated brain MRI screening as part of a comprehensive screening clinic called Li-Fraumeni Education and Early Detection (LEAD) at MD Anderson Cancer Center...
October 7, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28986375/stringent-response-regulators-contribute-to-the-recovery-from-glucose-phosphate-stress-in-escherichia-coli
#13
Julie R Kessler, Brandi L Cobe, Gregory R Richards
In enteric bacteria like Escherichia coli, the transcription factor SgrR and the small RNA SgrS regulate the response to glucose-phosphate stress, a metabolic dysfunction that results in growth inhibition and stems from the intracellular accumulation of sugar-phosphates. SgrR activates transcription of sgrS, and SgrS helps to rescue cells from stress in part by inhibiting uptake of stressor sugar-phosphates. While the regulatory targets of this stress response are well described, less is known about how the SgrR-SgrS response itself is regulated...
October 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28985953/effects-of-biodegradable-hydrogel-spacer-injection-on-contralateral-submandibular-gland-sparing-in-radiotherapy-for-head-and-neck-cancers
#14
Avani D Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M Rosati, Carole Fakhry, John Wong, Theodore L DeWeese, Harry Quon, Kai Ding, Ana Kiess
Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.
October 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28985178/sarcoidosis-mimicking-lytic-osseous-metastases
#15
Anahy M Brandy-García, Ivan Cabezas-Rodriguez, Luis Caminal-Montero, Carlos Suarez-Cuervo, Pilar Redondo-Buil
No abstract text is available yet for this article.
October 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28975221/association-of-an-asthma-improvement-collaborative-with-health-care-utilization-in-medicaid-insured-pediatric-patients-in-an-urban-community
#16
Carolyn M Kercsmar, Andrew F Beck, Hadley Sauers-Ford, Jeffrey Simmons, Brandy Wiener, Lisa Crosby, Susan Wade-Murphy, Pamela J Schoettker, Pavan K Chundi, Zeina Samaan, Mona Mansour
Importance: Asthma is the most common chronic condition of childhood. Hospitalizations and emergency department (ED) visits for asthma are more frequently experienced by minority children and adolescents and those with low socioeconomic status. Objective: To reduce asthma-related hospitalizations and ED visits for Medicaid-insured pediatric patients residing in Hamilton County, Ohio. Design, Setting, and Participants: From January 1, 2010, through December 31, 2015, a multidisciplinary team used quality-improvement methods and the chronic care model to conduct interventions in inpatient, outpatient, and community settings in a large, urban academic pediatric hospital in Hamilton County, Ohio...
September 18, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28973620/effect-of-genotype-guided-warfarin-dosing-on-clinical-events-and-anticoagulation-control-among-patients-undergoing-hip-or-knee-arthroplasty-the-gift-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Brian F Gage, Anne R Bass, Hannah Lin, Scott C Woller, Scott M Stevens, Noor Al-Hammadi, Juan Li, Tomás Rodríguez, J Philip Miller, Gwendolyn A McMillin, Robert C Pendleton, Amir K Jaffer, Cristi R King, Brandi DeVore Whipple, Rhonda Porche-Sorbet, Lynnae Napoli, Kerri Merritt, Anna M Thompson, Gina Hyun, Jeffrey L Anderson, Wesley Hollomon, Robert L Barrack, Ryan M Nunley, Gerard Moskowitz, Victor Dávila-Román, Charles S Eby
Importance: Warfarin use accounts for more medication-related emergency department visits among older patients than any other drug. Whether genotype-guided warfarin dosing can prevent these adverse events is unknown. Objective: To determine whether genotype-guided dosing improves the safety of warfarin initiation. Design, Setting, and Patients: The randomized clinical Genetic Informatics Trial (GIFT) of Warfarin to Prevent Deep Vein Thrombosis included patients aged 65 years or older initiating warfarin for elective hip or knee arthroplasty and was conducted at 6 US medical centers...
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28973182/perceived-importance-of-pursuing-osteopathic-recognition-in-the-single-accreditation-system-a-survey-of-medical-students-residents-and-faculty
#18
Kari Hortos, William Corser, Brandy Church, Jonathan Rohrer, Kirsten Waarala
Context: As graduate medical education evolves under the single accreditation system, osteopathic residency programs and consortia strive for sustainable ways to achieve and support the Osteopathic Recognition (OR) designation. Objective: To determine whether differences existed in perceived importance of OR from 3 cohorts of osteopathic stakeholders: students, residents, and faculty. Methods: A nonexperimental quantitative cross-sectional online survey was administered during February and March 2016 to osteopathic medical students at Michigan State University College of Osteopathic Medicine and residents and faculty from the affiliated Statewide Campus System...
October 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28967291/the-influence-of-physicochemical-properties-on-the-reactivity-and-stability-of-acyl-glucuronides
#19
Patrick Camilleri, Akshay Buch, Brandi Soldo, Andrew J Hutt
1. Formation of 1-O-acyl-β-D-glucuronide conjugates is a significant pathway in the metabolism of drugs containing a carboxylic acid group. The formation of acyl glucuronides results in an increase in both the aqueous solubility and molecular mass of the conjugate in comparison to the parent drug and thus facilitates excretion in both urine and bile. 2. Acyl glucuronides are effectively esters, which undergo first order decomposition by both hydrolysis and the intra-migration of the acyl group around the glucuronide ring to yield 2-, 3- and 4-O-glucuronic acid esters which, unlike the metabolically formed 1-O-acyl-β-D-glucuronides, are not substrates for β-glucuronidase...
October 2, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28967259/solid-state-nanopore-analysis-of-diverse-dna-base-modifications-using-a-modular-enzymatic-labeling-process
#20
Fanny Wang, Osama K Zahid, Brandi Swain, Derek Parsonage, Thomas Hollis, Scott Harvey, Dr Fred Perrino, Rahul M Kohli, Ethan W Taylor, Adam R Hall
Many regulated epigenetic elements and base lesions found in genomic DNA can both directly impact gene expression and play a role in disease processes. However, due to their non-canonical nature, they are challenging to assess with conventional technologies. Here, we present a new approach for the targeted detection of diverse modified bases in DNA. We first use enzymatic components of the DNA base excision repair pathway to install an individual affinity label at each location of a selected modified base with high yield...
October 2, 2017: Nano Letters
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