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https://www.readbyqxmd.com/read/28339884/paraneoplastic-panel-orders-in-the-context-of-an-existing-utilization-management-strategy
#1
Yaolin Zhou, Elizabeth M Staley, Brandi McCleskey, Benjamin Taylor, Robinna Lorenz
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28334921/internal-hydrolysis-indicator-for-sample-specific-monitoring-of-%C3%AE-glucuronidase-activity
#2
Lacy L Taylor, Noah A Flint, Vinh Ma, Brandy M Hill, Chantry J Clark, Frederick G Strathmann
Metabolized forms of benzodiazepines (benzos) can cause issues with mass spectrometry identification. Benzodiazepines undergo a process called glucuronidation during metabolism that attaches a glucuronic acid for increased solubility. Often in clinical testing an enzymatic hydrolysis step is implemented to increase the sensitivity of benzodiazepines by hydrolyzing β-D-glucuronic acid from benzodiazepine-glucuronide conjugates in urine samples using the β-Glucuronidase enzyme. In this study resorufin β-D-glucuronide, a substrate of the β-Glucuronidase enzyme, was added to patient samples to determine if proper hydrolysis had occurred...
March 18, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28332412/drug-safety-evaluation-of-parathyroid-hormone-for-hypocalcemia-in-patients-with-hypoparathyroidism
#3
Gemma Marcucci, Giuseppe Della Pepa, Maria Luisa Brandi
Hypoparathyroidism is a rare disorder characterized by low serum calcium levels and high serum phosphate levels. This disease is commonly treated with calcium supplements and active vitamin D metabolites or analogues, but large doses of these supplements are often utilized to relieve the symptoms caused by hypocalcemia, without guarantee of a physiological normalization of calcium-phosphate homeostasis. Areas covered: Several studies have investigated replacement therapy with recombinant human PTH [rhPTH (1-84) and rhPTH (1-34)] for subjects with hypoparathyroidism...
March 23, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28326239/nanostructured-carbon-materials-decorated-with-organophosphorus-moieties-synthesis-and-application
#4
Giacomo Biagiotti, Vittoria Langè, Cristina Ligi, Stefano Caporali, Maurizio Muniz-Miranda, Anna Flis, K Michał Pietrusiewicz, Giacomo Ghini, Alberto Brandi, Stefano Cicchi
A new synthetic approach for the production of carbon nanomaterials (CNM) decorated with organophosphorus moieties is presented. Three different triphenylphosphine oxide (TPPO) derivatives were used to decorate oxidized multiwalled carbon nanotubes (ox-MWCNTs) and graphene platelets (GPs). The TPPOs chosen bear functional groups able to react with the CNMs by Tour reaction (an amino group), nitrene cycloaddition (an azido group) or CuAAC reaction (one terminal C-C triple bond). All the adducts were characterized by FTIR, Raman spectroscopy, TEM, XPS, elemental analysis and ICP-AES...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28323974/phenotypic-spectrum-in-osteogenesis-imperfecta-due-to-mutations-in-tmem38b-unravelling-a-complex-cellular-defect
#5
Emma A Webb, Meena Balasubramanian, Nadja Fratzl-Zelman, Wayne A Cabral, Hannah Titheradge, Atif Alsaedi, Vrinda Saraff, Julie Vogt, Trevor Cole, Susan Stewart, Nicola J Crabtree, Brandi M Sargent, Sonja Gamsjaeger, Eleftherios P Paschalis, Paul Roschger, Klaus Klaushofer, Nick J Shaw, Joan C Marini, Wolfgang Högler
Context: Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Objectives: Clinical and bone material phenotype description and osteoblast differentiation studies. Design and Setting: Natural history study in paediatric research centres. Patients: Eight patients with type XIV OI. Main Outcome Measures: Clinical examinations included: bone mineral density, radiographs, echocardiography and muscle biopsy...
March 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28315148/a-case-of-cardiac-tamponade-due-to-an-isolated-abscess-in-the-ascending-aorta-of-a-pregnant-woman-with-a-history-of-intravenous-substance-abuse
#6
Brandy Shattuck, John Livingstone
We describe the case of a 23-year-old white female, 10-12 weeks pregnant, with a history of intravenous drug use and a recently diagnosed pneumonia, who was found deceased in her bed after a night of sleep. Although postmortem serum toxicology tested positive for alprazolam, tetrahydrocannabinol, and morphine, the ultimate cause of death was determined to be cardiac tamponade secondary to an isolated abscess in the ascending aorta. The patient had several risk factors for aortic rupture and cardiac tamponade including intravenous drug use, pneumonia, and pregnancy...
March 17, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28314252/clinical-target-volume-in-biliary-carcinoma-a-systematic-review-of-pathological-studies
#7
REVIEW
Ilaria Marinelli, Alessandra Guido, Lorenzo Fuccio, Andrea Farioli, Valeria Panni, Lucia Giaccherini, Alessandra Arcelli, Giorgio Ercolani, Giovanni Brandi, Silvia Cammelli, Andrea Galuppi, Gabriella Macchia, Rezarta Frakulli, Gian C Mattiucci, Francesco Cellini, Milly Buwenge, Matteo Renzulli, Francesco Deodato, Savino Cilla, Vincenzo Valentini, Vincenzo Tombolini, Rita Golfieri, Alessio G Morganti
BACKGROUND/AIM: Radiotherapy is a treatment option for both adjuvant and neo-adjuvant settings for biliary tract cancer. Guidelines on the delineation of the target volume of lymph nodes are lacking; only generic indications are available, without specific recommendations for different primary tumour locations (e.g. intrahepatic, extrahepatic biliary tract or gallbladder cancer). The aim of this study was to systematically review available literature to provide recommendations on lymph node target volume delineation in patients with unresectable biliary tumour...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28304263/battling-a-tangled-web-the-lived-experience-of-nurses-providing-end-of-life-care-on-an-acute-medical-unit
#8
Irene Oliveira, Frances Fothergill-Bourbonnais, Christine McPherson, Brandi Vanderspank-Wright
Meeting the heath care needs of patients at the end of life is becoming more complex. In Canada, most patients with life-limiting illness will die in hospitals, many on medical units. Yet, few studies have qualitatively investigated end-of-life care (EOLC) in this context, or from the perspectives of nurses providing EOLC. The purpose of this study was to seek to understand the lived experience of nurses on a medical unit providing EOLC to patients. Interpretive phenomenology guided the method and analysis...
November 1, 2016: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28304253/ventricular-parasystole-in-a-neonatal-rhesus-macaque-macaca-mulatta
#9
Dalis E Collins, Brandy L Dozier, Jeffrey J Stanton, Lois Ma Colgin, Rhonda MacAllister
A 6-d-old Indian-origin female rhesus macaque (Macaca mulatta) presented with bradycardia shortly after sedation with ketamine. No other cardiac abnormalities were apparent. Approximately 2 wk after the initial presentation, the macaque was again bradycardic and exhibited a regularly irregular arrhythmia on a prestudy examination. ECG, echocardiography, blood pressure measurement, SpO2 assessment, and a CBC analysis were performed. The echocardiogram and bloodwork were normal, but the infant was hypotensive at the time of echocardiogram...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28297895/gradient-driven-diffusion-and-pattern-formation-in-crowded-mixtures
#10
Prithviraj Nandigrami, Brandy Grove, Andrew Konya, Robin L B Selinger
Gradient-driven diffusion in crowded, multicomponent mixtures is a topic of high interest because of its role in biological processes such as transport in cell membranes. In partially phase-separated solutions, gradient-driven diffusion affects microstructure, which in turn affects diffusivity; a key question is how this complex coupling controls both transport and pattern formation. To examine these mechanisms, we study a two-dimensional multicomponent lattice gas model, where "tracer" molecules diffuse between a source and a sink separated by a solution of sticky "crowder" molecules that cluster to form dynamically evolving obstacles...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297709/erratum-single-cell-spatial-reconstruction-reveals-global-division-of-labour-in-the-mammalian-liver
#11
Keren Bahar Halpern, Rom Shenhav, Orit Matcovitch-Natan, Beáta Tóth, Doron Lemze, Matan Golan, Efi E Massasa, Shaked Baydatch, Shanie Landen, Andreas E Moor, Alexander Brandis, Amir Giladi, Avigail Stokar-Avihail, Eyal David, Ido Amit, Shalev Itzkovitz
No abstract text is available yet for this article.
March 15, 2017: Nature
https://www.readbyqxmd.com/read/28290007/impact-of-urban-neighborhood-disadvantage-on-late-stage-breast-cancer-diagnosis-in-virginia
#12
Pam Baker DeGuzman, Wendy F Cohn, Fabian Camacho, Brandy L Edwards, Vanessa N Sturz, Anneke T Schroen
Research suggests that residents of inner-city urban neighborhoods have higher rates of late stage cancer diagnosis. Identifying urban neighborhoods with high rates of both concentrated disadvantage and late stage cancer diagnosis may assist health care providers to target screening interventions to reduce disparities. The purposes of this study were to (1) create an index to evaluate concentrated disadvantage (CD) using non-racial measures of poverty, (2) determine the impact of neighborhood CD on late stage breast cancer diagnosis in US cities, and (3) to understand the role of obesity on this relationship...
March 13, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28289801/erratum-to-assessing-risk-of-osteoporotic-fractures-in-primary-care-development-and-validation-of-the-fra-hs-algorithm
#13
Francesco Lapi, Elisa Bianchini, Raffaella Michieli, Alessandro Pasqua, Iacopo Cricelli, Giampiero Mazzaglia, Bruno Frediani, Daniel Prieto-Alhambra, Maria Luisa Brandi, Claudio Cricelli
No abstract text is available yet for this article.
March 13, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28289299/disseminating-comparative-effectiveness-research-through-community-based-experiential-learning
#14
Richard A Hansen, Margaret Williamson, Lynn Stevenson, Brandy R Davis, R Lee Evans
Objectives. To launch and evaluate a comparative effectiveness research education and dissemination program as part of an introductory pharmacy practice experience (IPPE). Methods. First- through third-year PharmD students received training on comparative effectiveness research and disseminated printed educational materials to patients in the community who they were monitoring longitudinally (n=314). Students completed an assessment and initial visit documentation form at the first visit, and a follow-up assessment and documentation form at a subsequent visit...
February 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28289287/energy-transduction-and-alternating-access-of-the-mammalian-abc-transporter-p-glycoprotein
#15
Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A Koteiche, Robert K Nakamoto, Emad Tajkhorshid, Hassane S Mchaourab
ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding of the transduction of ATP energy to the work of substrate translocation remains elusive. Here we used double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as ABCB1), which has a central role in the clearance of xenobiotics and in cancer resistance to chemotherapy...
March 13, 2017: Nature
https://www.readbyqxmd.com/read/28288063/doctor-did-you-put-a-mesh-on-me-that-is-no-longer-recommended
#16
Claudio Brandi, Santiago Bertone, Sebastian Roche, Fernando Cetolini, Eugenia Fratantoni
No abstract text is available yet for this article.
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28285526/lipophilization-of-hydroxytyrosol-enriched-fractions-from-olea-europaea-l-by-products-and-evaluation-of-the-in-vitro-effects-on-a-model-of-colorectal-cancer-cells
#17
Roberta Bernini, Isabella Carastro, Gaia Palmini, Annalisa Tanini, Roberto Zonefrati, Patrizia Pinelli, Maria Luisa Brandi, Annalisa Romani
A hydroxytyrosol (HTyr)-enriched fraction containing HTyr 6% w/w, derived from Olea europaea L. by-products, obtained using an environmentally and economically sustainable technology was lipophilized under green chemistry conditions. The effects of three fractions containing hydroxytyrosyl butanoate, octanoate and oleate and unreacted HTyr, named, respectively, lipophilic fraction 5, 6 and 7, on the human colon cancer cell line HCT8-β8 engineered to overexpress estrogen receptor  (ER) were evaluated and compared to those of pure HTyr...
March 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28282807/radiological-pathological-correlation-in-alzheimer-s-disease-systematic-review-of-antemortem-magnetic-resonance-imaging-findings
#18
Caroline Dallaire-Théroux, Brandy L Callahan, Olivier Potvin, Stéphan Saikali, Simon Duchesne
BACKGROUND: The standard method of ascertaining Alzheimer's disease (AD) remains postmortem assessment of amyloid plaques and neurofibrillary degeneration. Vascular pathology, Lewy bodies, TDP-43, and hippocampal sclerosis are frequent comorbidities. There is therefore a need for biomarkers that can assess these etiologies and provide a diagnosis in vivo. OBJECTIVE: We conducted a systematic review of published radiological-pathological correlation studies to determine the relationship between antemortem magnetic resonance imaging (MRI) and neuropathological findings in AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28277873/periodontal-disease-and-women-s-health
#19
Maria Luisa Martelli, Maria Luisa Brandi, Marialaura Martelli, Piero Nobili, Enzo Medico, Francesco Martelli
BACKGROUND: Periodontal disease (PD) is a multifactorial inflammatory condition in which inappropriate interaction between the host immune response and specific groups of bacterial pathogens leads to destruction of connective and bone tissues supporting the tooth. Dissemination of pathogens, toxins, and immune complexes from and to periodontal lesions is at the basis of the increasingly recognized association between PD and various systemic diseases (SDs). Considering the growing attention of the medical community to "gender medicine", this review focuses on the association between PD and six systemic conditions heavily impacting women's health, with the aim of providing evidence in support of a joint effort between physicians and dentists to improve clinical management of these conditions...
March 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28276683/main-group-semiconductor-cluster-molecules-as-synthetic-intermediates-to-nanostructures
#20
Max R Friedfeld, Jennifer L Stein, Brandi M Cossairt
Main-group-semiconductor clusters are attractive atomically precise precursors for materials design. In particular, magic-sized clusters, those with elevated thermodynamic stability relative to other clusters of similar size, have been implicated as important intermediates in the synthesis of semiconductor nanostructures. A survey of the literature on the intermediacy of clusters in nanomaterial synthesis reveals two predominant mechanistic trends: monomer-driven growth and cluster assembly. In this Forum Article, we compare and contrast the systems in which these mechanisms are operative and attempt to extract the emerging design principles governing these transformations...
March 9, 2017: Inorganic Chemistry
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