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https://www.readbyqxmd.com/read/28221274/pharmacy-use-in-the-first-year-of-the-veterans-choice-program-a-mixed-methods-evaluation
#1
Walid F Gellad, Francesca E Cunningham, Chester B Good, Joshua M Thorpe, Carolyn T Thorpe, Brandi Bair, KatieLynn Roman, Susan L Zickmund
BACKGROUND: The Veterans Choice Program (VCP) was created to ensure timely access to health care in the Department of Veterans Affairs (VA). Under this program, medications may be ordered by select non-VA clinicians to be dispensed by VA pharmacies, creating new challenges in ensuring medication safety. OBJECTIVES: To examine pharmaceutical use during the first year of the VCP and to understand barriers and facilitators for VA pharmacists to dispensing medications under the VCP...
February 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28218286/vinculin-variant-m94i-identified-in-sudden-unexplained-nocturnal-death-syndrome-decreases-cardiac-sodium-current
#2
Jianding Cheng, John W Kyle, Brandi Wiedmeyer, Di Lang, Ravi Vaidyanathan, Jonathan C Makielski
Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy. We hypothesized VCL mutations underlie risk for SUNDS. A rare heterozygous variant VCL-M94I was found in a SUNDS victim who suffered sudden nocturnal tachypnea and lacked pathogenic variants in known arrhythmia-causing genes. VCL was identified to interact with SCN5A in vitro/vivo. The VCL-M94I was co-expressed with the cardiac sodium channel in HEK293 cells and also overexpressed in induced pluripotent stem cells derived cardiomyocytes (iPSCs-CM)...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216833/silicone-breast-implants-and-echocardiographic-interactions-a-brand-new-study
#3
Roberto Cuomo, Giuseppe Nisi, Luca Grimaldi, Cesare Brandi, Carlo D'Aniello
No abstract text is available yet for this article.
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28213492/peer-leadership-for-pharmacy-students
#4
Brett J Bailey, Brandi L Bowers, Drayton A Hammond
No abstract text is available yet for this article.
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28210823/non-ablative-erbium-yag-laser-for-the-treatment-of-type-iii-stress-urinary-incontinence-intrinsic-sphincter-deficiency
#5
Adrian Gaspar, Hugo Brandi
The objective of this pilot study was to determine the safety and efficacy of a new non-ablative erbium YAG laser procedure for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency) in women. Twenty-two patients with a Valsalva leak point pressure less than 60 cm H2O were recruited and treated with a non-ablative erbium laser delivering low fluence pulses inside the whole length of the urethra through a specially designed cannula. Treatment consisted of two treatment sessions with a 3-week interval in-between...
February 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28199835/rapid-automatic-motor-encoding-of-competing-reach-options
#6
Jason P Gallivan, Brandie M Stewart, Lee A Baugh, Daniel M Wolpert, J Randall Flanagan
Mounting neural evidence suggests that, in situations in which there are multiple potential targets for action, the brain prepares, in parallel, competing movements associated with these targets, prior to implementing one of them. Central to this interpretation is the idea that competing viewed targets, prior to selection, are rapidly and automatically transformed into corresponding motor representations. Here, by applying target-specific, gradual visuomotor rotations and dissociating, unbeknownst to participants, the visual direction of potential targets from the direction of the movements required to reach the same targets, we provide direct evidence for this provocative idea...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28198194/assessing-the-clinical-utility-of-the-question-is-your-child-are-you-back-to-normal-in-pediatric-concussion-symptom-resolution
#7
Brandi L Vollmer, Michael W Kirkwood, R Dawn Comstock, Dustin Currie, Joseph A Grubenhoff
This study investigates the relationship between the general question, "Is your child/are you back to normal?" and a validated postconcussive symptom scale when assessing symptom resolution following concussion. Children with acute concussion were enrolled during an emergency department visit. Sensitivity and specificity analyses compared the true/false question, "My child is/I am back to normal" at 3 days postinjury with the Concussion Symptom Inventory (CSI; gold standard). A total of 201 participants were enrolled in the study with complete data...
February 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28192856/persistent-double-dorsal-aorta-a-systematic-review-of-the-literature
#8
Brandy Mills, Thomas Gest
INTRODUCTION: Our discovery of a case of persistent double dorsal aorta prompted us to systematically review the literature of all previously reported cases of this anomaly. For our case, we present a completely separated double dorsal aorta, with the right accessory aorta arising from the abdominal aorta and ascending through the aortic hiatus to supply posterior intercostal arteries (PIAs) to the 9(th) -3(rd) spaces bilaterally. MATERIALS AND METHODS: We examined and compiled data from the ten previously reported cases, along with our observations from our cadaver, into a systematic review of all known cases of persistent double dorsal aorta...
February 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28179975/particulate-release-from-nanoparticle-loaded-shape-memory-polymer-foams
#9
Adam L Nathan, Grace K Fletcher, Mary Beth B Monroe, Wonjun Hwang, Scott M Herting, Sayyeda M Hasan, Brandis K Keller, Duncan J Maitland
Highly porous, open-celled shape memory polymer (SMP) foams are being developed for a number of vascular occlusion devices. Applications include abdominal aortic and neurovascular aneurysm or peripheral vascular occlusion. A major concern with implanting these high surface area materials in the vasculature is the potential to generate unacceptable particulate burden, in terms of number, size, and composition. This study demonstrates that particulate numbers and sizes in SMP foams are in compliance with limits stated by the most relevant standard and guidance documents...
March 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/28168608/barriers-facilitators-and-benefits-of-implementation-of-dialectical-behavior-therapy-in-routine-care-results-from-a-national-program-evaluation-survey-in-the-veterans-health-administration
#10
Sara J Landes, Allison L Rodriguez, Brandy N Smith, Monica M Matthieu, Lindsay R Trent, Janet Kemp, Caitlin Thompson
National implementation of evidence-based psychotherapies (EBPs) in the Veterans Health Administration (VHA) provides important lessons on the barriers and facilitators to implementation in a large healthcare system. Little is known about barriers and facilitators to the implementation of a complex EBP for emotional and behavioral dysregulation-dialectical behavioral therapy (DBT). The purpose of this study was to understand VHA clinicians' experiences with barriers, facilitators, and benefits from implementing DBT into routine care...
February 6, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28167431/adeno-associated-viral-vector-mediated-preprosomatostatin-expression-suppresses-induced-seizures-in-kindled-rats
#11
Gowri Natarajan, Jeffrey A Leibowitz, Junli Zhou, Yang Zhao, Jessica A McElroy, Michael A King, Brandi K Ormerod, Paul R Carney
Somatostatin is expressed widely in the hippocampus and notably in hilar GABAergic neurons that are vulnerable to seizure neuropathology in chronic temporal lobe epilepsy. We previously demonstrated that sustained bilateral preprosomatostatin (preproSST) expression in the hippocampus prevents the development of generalized seizures in the amygdala kindling model of temporal lobe epilepsy. Here we tested whether sustained preproSST expression is anticonvulsant in rats already kindled to high-grade seizures. Rats were kindled until they exhibited 3 consecutive Racine Grade 5 seizures before adeno-associated virus serotype 5 (AAV5) vector driving either eGFP (AAV5-CBa-eGFP) or preproSST and eGFP (AAV5-CBa-preproSST-eGFP) expression was injected bilaterally into the hippocampal dentate gyrus and CA1 region...
January 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28166538/single-cell-spatial-reconstruction-reveals-global-division-of-labour-in-the-mammalian-liver
#12
Keren Bahar Halpern, Rom Shenhav, Orit Matcovitch-Natan, Beáta Tóth, Doron Lemze, Matan Golan, Efi E Massasa, Shaked Baydatch, Shanie Landen, Andreas E Moor, Alexander Brandis, Amir Giladi, Avigail Stokar-Avihail, Eyal David, Ido Amit, Shalev Itzkovitz
The mammalian liver consists of hexagon-shaped lobules that are radially polarized by blood flow and morphogens. Key liver genes have been shown to be differentially expressed along the lobule axis, a phenomenon termed zonation, but a detailed genome-wide reconstruction of this spatial division of labour has not been achieved. Here we measure the entire transcriptome of thousands of mouse liver cells and infer their lobule coordinates on the basis of a panel of zonated landmark genes, characterized with single-molecule fluorescence in situ hybridization...
February 16, 2017: Nature
https://www.readbyqxmd.com/read/28163344/predictors-of-prosocial-behavior-differences-in-middle-aged-and-older-adults
#13
Jennifer R Wenner, Brandy A Randall
Generativity, contributing to the next generation, is important for well-being throughout middle and late life. Therefore, it is crucial to understand what contributes to generativity during these life stages. Parenting and work are common, but not the only, ways people engage generatively; prosocial behavior is another. A community connection may encourage generative contributions in adults. However, older adults may face obstacles to being generative, and may need an additional drive to engage in these behaviors...
October 2016: Personality and Individual Differences
https://www.readbyqxmd.com/read/28163105/nerve-growth-factor-derivative-ngf61-100-promotes-outgrowth-of-primary-sensory-neurons-with-reduced-signs-of-nociceptive-sensitization
#14
C Severini, P Petrocchi Passeri, M T Ciotti, F Florenzano, C Petrella, F Malerba, B Bruni, M D'Onofrio, I Arisi, R Brandi, R Possenti, P Calissano, A Cattaneo
Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease. However, the development of an NGF-based therapy is limited by its potent pain activity. We have developed a "painless" derivative form of human NGF (NGF61/100), characterized by identical neurotrophic properties but a reduced nociceptive sensitization activity in vivo. Here we characterized the response of rat dorsal root ganglia neurons (DRG) to the NGF derivative NGF61/100, in comparison to that of control NGF (NGF61), analyzing the expression of noxious pro-nociceptive mediators...
February 2, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28161859/infant-adiposity-is-independently-associated-with-a-maternal-high-fat-diet-but-not-related-to-niacin-intake-the-healthy-start-study
#15
Allison L B Shapiro, Brandy M Ringham, Deborah H Glueck, Jill M Norris, Linda A Barbour, Jacob E Friedman, Dana Dabelea
Objectives Over-nutrition during pregnancy resulting from maternal obesity or an unhealthy diet can lead to excess infant adiposity at birth. Specific dietary macro- and micronutrients have been shown to increase fat cell development in both in-vitro and in-vivo models and may therefore link maternal diet to increased infant adiposity. We hypothesized that high maternal dietary niacin intake during pregnancy, especially in combination with a high-fat diet (HFD) would increase infant adiposity. Methods We included 1040 participants from a pre-birth cohort of mother-infant pairs...
February 4, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28161200/predictors-of-infant-body-composition-at-5-months-of-age-the-healthy-start-study
#16
Katherine A Sauder, Jill L Kaar, Anne P Starling, Brandy M Ringham, Deborah H Glueck, Dana Dabelea
OBJECTIVE: To examine associations of demographic, perinatal, and infant feeding characteristics with offspring body composition at approximately 5 months of age. STUDY DESIGN: We collected data on 640 mother/offspring pairs from early pregnancy through approximately 5 months of age. We assessed offspring body composition with air displacement plethysmography at birth and approximately 5 months of age. Linear regression analyses examined associations between predictors and fat-free mass, fat mass, and percent fat mass (adiposity) at approximately 5 months...
February 1, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161005/surgery-investigators-funded-through-the-national-institutes-of-health-a-rebirth
#17
Yinin Hu, Brandy L Edwards, Kevin Hu, Kendall D Brooks, Craig L Slingluff
BACKGROUND: Funding toward surgical research through the National Institutes of Health has decreased relative to other medical specialties. This study was initiated to characterize features of academically successful surgeon-scientists and departments of surgery. We hypothesized that there may be decreases in young investigators obtaining independent National Institutes of Health awards and that successful academic departments of surgery may be depending increasingly on PhD faculty. METHODS: The National Institutes of Health RePORTER database was queried for grants awarded to departments of surgery during fiscal years 2003 and 2013...
February 1, 2017: Surgery
https://www.readbyqxmd.com/read/28160251/erratum-to-pediatric-emergency-medicine-point-of-care-ultrasound-summary-of-the-evidence
#18
Jennifer R Marin, Alyssa M Abo, Alexander C Arroyo, Stephanie J Doniger, Jason W Fischer, Rachel Rempell, Brandi Gary, James F Holmes, David O Kessler, Samuel H F Lam, Marla C Levine, Jason A Levy, Alice Murray, Lorraine Ng, Vicki E Noble, Daniela Ramirez-Schrempp, David C Riley, Turandot Saul, Vaishali Shah, Adam B Sivitz, Ee Tein Tay, David Teng, Lindsey Chaudoin, James W Tsung, Rebecca L Vieira, Yaffa M Vitberg, Resa E Lewiss
No abstract text is available yet for this article.
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28160026/assessing-risk-of-osteoporotic-fractures-in%C3%A2-primary-care-development-and-validation-of-the-fra-hs-algorithm
#19
Lapi Francesco, Bianchini Elisa, Michieli Raffaella, Pasqua Alessandro, Cricelli Iacopo, Mazzaglia Giampiero, Frediani Bruno, Prieto-Alhambra Daniel, Brandi Maria Luisa, Cricelli Claudio
We aimed to develop and validate the FRActure Health Search (FRA-HS) score for prediction of risk of osteoporotic fractures in primary care in Italy. We selected a cohort of patients aged 40 years between 1999 and 2002. They were followed until the occurrence of osteoporotic fracture, death, end of data registration, or end of data availability (December 31, 2012). Age, sex, history of osteoporotic fractures, secondary osteoporosis, long-term use of corticosteroids, rheumatoid arthritis, body mass index, smoking, and alcohol abuse/alcohol-related diseases, and the interaction terms sex*use of corticosteroids and age*secondary osteoporosis were entered in a competing-risk regression (Fine and Gray method) to predict the risk of hip/femur or overall major osteoporotic fractures...
February 3, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28159297/validation-and-application-of-a-quantitative-real-time-pcr-assay-to-detect-common-wheat-adulteration-of-durum-wheat-for-pasta-production
#20
Elisa Carloni, Giulia Amagliani, Enrica Omiccioli, Veronica Ceppetelli, Michele Del Mastro, Luca Rotundo, Giorgio Brandi, Mauro Magnani
Pasta is the Italian product par excellence and it is now popular worldwide. Pasta of a superior quality is made with pure durum wheat. In Italy, addition of Triticum aestivum (common wheat) during manufacturing is not allowed and, without adequate labeling, its presence is considered an adulteration. PCR-related techniques can be employed for the detection of common wheat contaminations. In this work, we demonstrated that a previously published method for the detection of T. aestivum, based on the gliadin gene, is inadequate...
June 1, 2017: Food Chemistry
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