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https://www.readbyqxmd.com/read/28729205/antimicrobial-susceptibility-of-clostridium-difficile-isolates-in-israel
#1
Linda Tkhawkho, Orna Nitzan, Nina Pastukh, Diana Brodsky, Karen Jackson, Avi Peretz
OBJECTIVES: An increase of Clostridium difficile isolates with reduced susceptibility to various antimicrobial agents has been observed, including isolates that are non-susceptible to antibiotics that are routinely used for treatment of C. difficile, such as vancomycin and metronidazole. We determined the susceptibility rates of C. difficile isolates from hospitals in northern Israel to various antibiotics including tigecycline, which was not previously reported from Israel. METHODS: A total of 81 stool samples were collected from three hospitals in northern Israel from patients with C...
July 17, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28716360/comparison-of-synergism-between-colistin-fosfomycin-and-tigecycline-against-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolates-or-with-carbapenem-resistance
#2
Yee-Huang Ku, Chi-Chung Chen, Mei-Feng Lee, Yin-Ching Chuang, Hung-Jen Tang, Wen-Liang Yu
PURPOSE: To investigate the synergistic and bactericidal effects of antimicrobial combinations of any two of colistin, fosfomycin and tigecycline against the nine extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (KP) clinical isolates, including 4 carbapenem-susceptible strains and five imipenem and/or meropenem-resistant strains. METHODS: In vitro synergism and bactericidal activity of combination of colistin, fosfomycin and tigecycline were evaluated by time-kill studies in standard inoculum of bacterial densities of a suspension containing 5 × 10(5) CFU/mL by using 1/2× MIC for each alone, and both 1/2× and 1/4× MIC for any two drugs...
July 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28713357/extensively-drug-resistant-klebsiella-pneumoniae-causing-nosocomial-bloodstream-infections-in-china-molecular-investigation-of-antibiotic-resistance-determinants-informing-therapy-and-clinical-outcomes
#3
Wenzi Bi, Haiyang Liu, Rhys A Dunstan, Bin Li, Von Vergel L Torres, Jianming Cao, Lijiang Chen, Jonathan J Wilksch, Richard A Strugnell, Trevor Lithgow, Tieli Zhou
The rise in diversity of antimicrobial resistance phenotypes seen in Klebsiella pneumoniae is becoming a serious antibiotic management problem. We sought to investigate the molecular characteristics and clinical implications of extensively drug-resistant (XDR) K. pneumoniae isolated from different nosocomial bloodstream infections (BSIs) patients from July 2013 to November 2015. Even in combination treatment, meropenem did not protect against mortality of BSIs patients (P = 0.015). In contrast, tigecycline in combination with other antimicrobial agents significantly protected against mortality (P = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712104/do-bacteria-isolated-from-icu-patients-eskape-antibiotic-treatment-in-vitro-susceptibility-of-the-enterobacteriaceae-family-to-tigecycline
#4
Katarzyna Talaga-Ćwiertnia, Paweł Krzyściak, Małgorzata Bulanda
BACKGROUND: Enterobacteriaceae are currently causing the majority of healthcare-associated infections (HAI) and simultaneously expressing increasing levels of antibiotic resistance. The purpose of this study is to assess the in vitro sensitivity of MDR strains from the family Enterobacteriaceae to tigecycline in relation to their origin from patients hospitalized in intensive care units (ICUs) and non-ICUs. METHODS: The study involved 156 clinically-significant strains of the Enterobacteriaceae family isolated from patients with cIAIs and/or cSSSIs hospitalized in ICUs and other surgical departments...
July 16, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28706393/cotrimoxazole-a-wonder-drug-in-the-era-of-multiresistance-case-report-and-review-of-literature
#5
Priyam Batra, Vishant Deo, Purva Mathur, Amit Kumar Gupta
Antimicrobial resistance is one of the greatest threats to human health worldwide. The rate of development of newer antibiotics is much slower than the rate of development of antibiotic resistance. A survey reported that it takes 15 years and US$800 million (including preclinical and clinical costs) to bring a single drug to the market, whereas the reuse of the older drugs for antimicrobial use takes $17 million, thereby circumventing 40% of the overall cost. The first case is a patient with nosocomial pyrexia of unknown origin who was given treatment with tigecycline and cefepime/tazobactam but failed to respond to the same...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28705668/in-vitro-activity-of-the-novel-fluorocycline-eravacycline-against-carbapenem-non-susceptible-acinetobacter-baumannii
#6
Harald Seifert, Danuta Stefanik, Joyce A Sutcliffe, Paul G Higgins
The activity of eravacycline was compared with anti-Acinetobacter reference antimicrobials against carbapenem non-susceptible Acinetobacter baumannii isolates associated with an acquired OXA or up-regulation of the intrinsic OXA-51-like enzyme. Antimicrobial susceptibility testing was performed by broth microdilution of 286 non-duplicate, carbapenem non-susceptible A. baumannii isolates to eravacycline, amikacin colistin, doxycycline, imipenem, levofloxacin, meropenem, minocycline, sulbactam, tigecycline, and tobramycin...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28701170/antimicrobial-susceptibility-among-gram-positive-and-gram-negative-organisms-collected-from-the-latin-american-region-between-2004-and-2015-as-part-of-the-tigecycline-evaluation-and-surveillance-trial
#7
Silvio Vega, Michael J Dowzicky
BACKGROUND: The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global surveillance study. METHODS: Minimum inhibitory concentrations (MICs) were determined using the broth microdilution methodology according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
July 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28696233/comparison-of-omadacycline-and-tigecycline-pharmacokinetics-in-the-plasma-epithelial-lining-fluid-and-alveolar-cells-in-healthy-adult-subjects
#8
Mark H Gotfried, Karolyn Horn, Lynne Garrity-Ryan, Stephen Villano, Evan Tzanis, Surya Chitra, Amy Manley, S Ken Tanaka, Keith A Rodvold
The steady-state concentrations of omadacycline and tigecycline in plasma, epithelial lining fluid (ELF), and alveolar cells (AC) concentrations were obtained in 58 healthy adult subjects. Subjects were administered either omadacycline as 100 mg intravenously (IV) every 12 hours for two doses followed by 100 mg IV every 24 hours for three doses or tigecycline as an initial dose of 100 mg IV followed by 50 mg IV every 12 hours for six doses. A bronchoscopy and bronchoalveolar lavage were performed once in each subject following the start of the fifth dose of omadacycline at 0...
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28694232/reinforcement-of-an-antimicrobial-stewardship-task-force-aims-at-a-better-use-of-antibiotics-of-last-resort-the-colitifos-study
#9
Benjamin Davido, Frédérique Bouchand, Aurélien Dinh, Christian Perronne, Maryvonne Villart, Olivia Senard, Jérome Salomon
BACKGROUND: Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available. METHODS: A before and after retrospective study was conducted from January 2008 to June 2016. Prescriptions of parenteral antimicrobials considered as last-resort antibiotics (colistin, fosfomycin, tigecycline and temocillin) were reviewed by 4 infectious disease specialists (according to microbiology results, susceptibility testing, clinical situation and alternative agents), while doses were analyzed by a pharmacist...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28693926/high-in%C3%A2-vitro-activity-of-fidaxomicin-against-clostridium-difficile-isolates-from-a-university-teaching-hospital-in-china
#10
Jing-Wei Cheng, Qi-Wen Yang, Meng Xiao, Shu-Ying Yu, Meng-Lan Zhou, Timothy Kudinha, Fanrong Kong, Jian-Wei Liao, Ying-Chun Xu
BACKGROUND: Clostridium difficile infection (CDI) is a significant cause of morbidity and mortality in both the acute care setting and the wider healthcare system. The purpose of this study was to evaluate the in vitro activity of fidaxomicin against C.difficile isolates from a university teaching hospital in China. METHODS: One hundred and one C.difficile isolates were collected and analyzed for toxin genes by multiplex PCR. The toxin gene positive strains were also typed by multilocus sequence typing (MLST) and PCR-ribotyping...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28693691/prevalence-of-carbapenem-resistant-klebsiella-pneumoniae-crkp-and-the-distribution-of-class-1-integron-in-their-strains-isolated-from-a-hospital-in-central-china
#11
Ou Qin, Li Wenfang, Li Bei, Yu Chunfang
Objective The aim of our study is to investigate the prevalence of Carbapenem-resistant Klebsiella pneumoniae (CRKP) and the genetic characteristics of the class 1 integron in CRKP on multi-drug resistance.Methods Clinical Klebsiella pneumoniae strains were collected from multiple departments of a hospital in central China. CRKP strains were identified among the isolates, and antibiotics susceptibility of CRKP strains was analyzed. The polymerase chain reaction (PCR) was adopted to amplify the class 1 integron variable area...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28692823/high-hiv-infection-prevalence-in-a-group-of-men-who-have-sex-with-men-msm
#12
Raquel Maria Cardoso Torres, Marly Marques da Cruz, André Reynaldo Santos Périssé, Denise Ribeiro Franqueira Pires
OBJECTIVE: To evaluate, by phenotypic and genotypic parameters, the presence of virulence and resistance factors in clinical Acinetobacter baumannii strains and verify the correlation between these variables. SETTINGS: Observational study conducted in an Universitary Hospital in Belo Horizonte, Brazil. METHODS: The confirmation of A. baumannii-calcoaceticus complex was performed by blaOXA51 detection, through the polymerase chain reaction (PCR) multiplex, as well as to investigate the presence of other oxacillinases (blaOXA23, 24, 58)...
July 7, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28689923/in-vitro-activity-of-ceftolozane-tazobactam-in-combination-with-other-classes-of-antibacterial-agents
#13
Cédric Jacqueline, Karen Howland, Laurent Chesnel
OBJECTIVES: Combination antibiotic therapy has been used successfully to treat some patients with bacterial infections. However, although certain combinations may result in beneficial synergistic activity, others may produce antagonistic effects resulting in poor treatment outcomes. Ceftolozane/tazobactam is an antibacterial agent with potent activity against Pseudomonas aeruginosa and many other Gram-negative pathogens, including extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae...
July 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28687975/prevalence-and-drug-resistance-characteristics-of-carbapenem-resistant-enterobacteriaceae-in-hangzhou-china
#14
Yan Yang, Jian Chen, Di Lin, Xujian Xu, Jun Cheng, Changgui Sun
With the abuse of antimicrobial agents in developing countries, increasing number of carbapenem-resistant Enterobacteriaceae (CRE) attracted considerable public concern. A retrospective study was conducted based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drug resistance characteristics of CRE in southeast China. Bacterial species were identified. Antimicrobial susceptibility was examined by broth microdilution method or epsilometer test. Resistant β-lactamase genes were identified by polymerase chain reaction and sequencing...
July 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28687078/prolonged-and-high-dosage-of-tigecycline-successful-treatment-of-spondylodiscitis-caused-by-multidrug-resistant-acinetobacter-baumannii-a-case-report
#15
Olga Tsachouridou, Adamantini Georgiou, Sideris Nanoudis, Theofilos Chrysanthidis, Georgia Loli, Petros Morfesis, Pantelis Zebekakis, Symeon Metallidis
BACKGROUND: The incidence of infectious spondylodiscitis has been increasing over the last few years. This reflects the expanding elderly and immunocompromised populations and the rising implementation of invasive spinal procedures. Infection may be inoculated into the disc space directly during invasive spinal procedures. Osteomyelitis caused by Acinetobacter species is rare and mainly caused by multidrug-resistant strains. CASE PRESENTATION: We present the case of a 72-year-old Greek woman with postoperative spondylodiscitis caused by a multidrug-resistant Acinetobacter baumannii strain that was successfully treated, after she declined surgical treatment, with prolonged and high dosage of tigecycline...
July 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28679413/double-carbapenem-as-a-rescue-strategy-for-the-treatment-of-severe-carbapenemase-producing-klebsiella-pneumoniae-infections-a-two-center-matched-case-control-study
#16
Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane, Massimo Antonelli
BACKGROUND: Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate the clinical impact of such a regimen in critically ill patients. METHODS: This case-control (1:2), observational, two-center study involved critically ill adults with a microbiologically documented CR-Kp invasive infection treated with the DC regimen matched with those receiving a standard treatment (ST) (i...
July 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28677837/determination-of-tigecycline-in-human-plasma-by-lc-ms-ms-and-its-application-to-population-pharmacokinetics-study-in-chinese-patients-with-hospital-acquired-pneumonia
#17
Rong Shao, Xingang Li, Yangmin Hu, Jinliang Chen, Honggang Lou, Haibin Dai
A selective, sensitive, and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of Tigecycline (TGC) in human plasma, using Tigecycline-d9 as an internal standard (IS). Analytical samples were prepared using a protein precipitation method coupled with a concentration process. The analyte and IS were separated on a reversed-phase Waters Acquity UPLC® BEH-C18 column (2.1 mm × 50 mm ID, 1.7 μm) with a flow rate of 0.25 ml/min. The mobile phase consisted of water, containing 0...
July 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28676346/bloodstream-infections-caused-by-acinetobacter-species-with-reduced-susceptibility-to-tigecycline-clinical-features-and-risk-factors
#18
Ga Eun Park, Cheol-In Kang, Min Kyeong Cha, Sun Young Cho, Hyeri Seok, Ji Hye Lee, Ji Yeon Kim, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
INTRODUCTION: During recent decades, the rates of multidrug resistance, including resistance to carbapenems, have increased dramatically among Acinetobacter species. Tigecycline has activity against multidrug-resistant Acinetobacter spp, including carbapenem-resistant isolates. However, reports of tigecycline-resistant Acinetobacter spp are emerging from different parts of the world. The purpose of this study was to evaluate potential risk factors associated with tigecycline non-susceptible Acinetobacter bacteremia...
July 1, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28674056/clinical-features-of-breakthrough-acinetobacter-bacteremia-during-carbapenem-therapy-a-multicenter-study
#19
Yi-Tzu Lee, Yung-Chih Wang, Shu-Chen Kuo, Chung-Ting Chen, Chang-Pan Liu, Yuag-Meng Liu, Te-Li Chen, Ya-Sung Yang
Breakthrough Acinetobacter bacteremia during carbapenem therapy is not uncommon and creates therapeutic dilemmas for clinicians. This study was conducted to evaluate the clinical and microbiological characteristics of breakthrough Acinetobacter bacteremia during carbapenem therapy and to assess the efficacy of various antimicrobial therapies. We analyzed 100 adults who developed breakthrough Acinetobacter bacteremia during carbapenem therapy at 4 medical centers over a 6-year period. Their 30-day mortality rate was 57...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28670975/carbapenem-resistant-klebsiella-pneumoniae-isolated-from-bloodstream-infection-indian-experience
#20
Balaji Veeraraghavan, Chaitra Shankar, Susmitha Karunasree, Shantha Kumari, Raji Ravi, Ravikar Ralph
Increased incidence of multidrug resistant (MDR) Gram negative infection has resulted in high rates of morbidity and mortality. Klebsiella pneumoniae is one of the commonest MDR pathogens causing bacteraemia with limited therapeutic options such as colistin and tigecycline. Present study focused on molecular characterisation of MDR K. pneumoniae from bloodstream infection and their clinical outcome. A total of 115 K. pneumoniae from January 2015 to September 2016 were included in the study which comprised of phenotypically identified ESBL and carbapenem resistant (CR) isolates...
July 2, 2017: Pathogens and Global Health
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