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https://www.readbyqxmd.com/read/29456841/successful-treatment-of-extensively-drug-resistant-acinetobacter-baumannii-ventriculitis-with-polymyxin-b-and-tigecycline-a-case-report
#1
Wei Guo, Shao-Chun Guo, Min Li, Li-Hong Li, Yan Qu
Background: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier. Case presentation: A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29450214/-mycobacterium-abscessus-complex-infections-a-retrospective-cohort-study
#2
Maroun Sfeir, Marissa Walsh, Rossana Rosa, Laura Aragon, Sze Yan Liu, Timothy Cleary, Marylee Worley, Corey Frederick, Lilian M Abbo
Background: Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States. Methods: A retrospective cohort study of hospitalized adults with a positive culture for M. abscessus in Miami, Florida (January 1, 2011, to December 31, 2014). Demographics, comorbidities, the source of infection, antimicrobial susceptibilities, and clinical outcomes were analyzed...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29448851/salvage-tigecycline-in-high-risk-febrile-neutropenic-patients-with-hematological-malignancies-a-prospective-multicenter-study
#3
Xin-Ping Zhou, Xiu-Jin Ye, Jian-Ping Shen, Jian-Ping Lan, Hui-Fang Jiang, Jin Zhang, Xue-Jin Zhang, Li Li, Shen-Xian Qian, Hong-Yan Tong
The purpose of this prospective, multi-center study was to examine the efficacy and safety of tigecycline as empirical treatment in neutropenic patients with hematological malignancies who failed to respond to first-line antibiotics. A total of 125 patients with persistent fever (>72 h) despite first-line antibiotics received empirical treatment with tigecycline (loading dose of 100 mg, followed by 50 mg every 12 h). The use of other antimicrobial agents was not restricted. Treatment success rate was 68...
February 16, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29444952/treatment-of-infections-caused-by-extended-spectrum-beta-lactamase-ampc-and-carbapenemase-producing-enterobacteriaceae
#4
REVIEW
Jesús Rodríguez-Baño, Belén Gutiérrez-Gutiérrez, Isabel Machuca, Alvaro Pascual
Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is challenging, and some of the few active drugs are not available in many countries. For extended-spectrum β-lactamase and AmpC producers, carbapenems are the drugs of choice, but alternatives are needed because the rate of carbapenem resistance is rising. Potential active drugs include classic and newer β-lactam-β-lactamase inhibitor combinations, cephamycins, temocillin, aminoglycosides, tigecycline, fosfomycin, and, rarely, fluoroquinolones or trimethoprim-sulfamethoxazole...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29416274/trend-analysis-of-bacterial-uropathogens-and-their-susceptibility-pattern-a-4-year-2013-2016-study-from-aseer-region-saudi-arabia
#5
Abdulaziz Alamri, Mohamed E Hamid, Muhammad Abid, Abdulrahman M Alwahhabi, Khalid M Alqahtani, Mohammed S Alqarni, Mosleh Abomughaid
Purpose: To analyze the prevalence and resistance rates of bacterial agents causing urinary tract infections (UTIs) in Aseer, Saudi Arabia (2013-2016). Patients and Methods: This was a 4-year (2013-2016) retrospective study undertaken in Aseer Central Hospital, Saudi Arabia. A total of 49,779 urine and other UT specimens obtained from patients suspected of having a UTI were analyzed. Urine specimens were inoculated onto cystine lactose electrolyte deficient agar following standard procedures...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29411661/novel-pharmacotherapy-for-the-treatment-of-hospital-acquired-and-ventilator-associated-pneumonia-caused-by-resistant-gram-negative-bacteria
#6
James M Kidd, Joseph L Kuti, David P Nicolau
Introduction Hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) are among the most prevalent infections in hospitalized patients, particularly those in the intensive care unit. Importantly, the frequency of multidrug resistant (MDR) Gram-negative (GN) bacteria as the bacteriologic cause of HABP/VABP is increasing. These include MDR Pseudomonas aeruginosa, Acinetobacter baumannii, and carbapenem resistant Enterobactericeae (CRE). Few antibiotics are currently available when such MDR Gram-negatives are encountered and older agents such as polymyxin B, colistin (polymyxin E), and tigecycline have typically performed poorly in HABP/VABP...
February 7, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29410368/surveillance-of-tigecycline-activity-tested-against-clinical-isolates-from-a-global-north-america-europe-latin-america-and-asia-pacific-collection-2016
#7
Michael A Pfaller, Michael D Huband, Jennifer Streit, Robert K Flamm, Helio S Sader
Tigecycline and comparators were tested by reference broth microdilution method against 33,348 non-duplicate bacterial isolates collected prospectively in 2016 from medical centers in Asia-Pacific (3,443 isolates), Europe (13,530 isolates), Latin America (3,327 isolates), and United States (13,048 isolates). Among 7,098 Staphylococcus aureus isolates tested, >99.9% were inhibited by ≤0.5 mg/L of tigecycline (MIC50/90, 0.06/0.12 mg/L), including >99.9% of methicillin-resistant S. aureus and 100.0% of methicillin-susceptible S...
February 1, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29410250/differences-in-the-rate-of-carbapenem-resistant-enterobacteriaceae-colonization-or-clostridium-difficile-infection-following-frontline-treatment-with-tigecycline-versus-meropenem-for-intra-abdominal-infections
#8
Michele Bartoletti, Sara Tedeschi, Renato Pascale, Luigi Raumer, Alberto Enrico Maraolo, Giulia Palmiero, Fabio Tumietto, Francesco Cristini, Simone Ambretti, Maddalena Giannella, Russell Edward Lewis, Pierluigi Viale
OBJECTIVES: We hypothesized that treatment with a tigecycline-based antimicrobial regimens for intra-abdominal-infection (IAI) could be associated with lower rates of subsequent for carbapenem-resistant Enterobacteriaceae (CRE) colonization or Clostridium difficile infection (CDI) compared to a meropenem-based regimen. Methods We performed a retrospective, single-centre, matched (1:1) cohort analysis of all patients who received at least five days of TIG or MER-based, empiric or targeted, treatment regimens for IAI, over a 50-month period...
February 1, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29410094/antibiotic-treatment-of-infections-caused-by-carbapenem-resistant-gram-negative-bacilli-an-international-escmid-cross-sectional-survey-among-infection-diseases-specialists-practicing-in-large-hospitals
#9
Lea Papst, Bojana Beović, Céline Pulcini, Emanuele Durante-Mangoni, Jesús Rodríguez-Baño, Keith S Kaye, George L Daikos, Lul Raka, Mical Paul
OBJECTIVES: To explore contemporary antibiotic management of infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB) in hospitals. METHODS: Cross-sectional, internet-based questionnaire survey. We contacted representatives of all hospitals with more than 800 acute-care hospital beds in France, Greece, Israel, Italy, Kosovo, Slovenia, Spain and selected hospitals in the United States. We asked respondents to describe the most common actual practice at their hospital regarding management of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa through close-ended questions...
January 30, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29405898/efficacy-and-safety-of-tigecycline-monotherapy-versus-combination-therapy-for-the-treatment-of-hospital-acquired-pneumonia-hap-a-meta-analysis-of-cohort-studies
#10
Xiang-Rong Bai, Jia-Ming Liu, De-Chun Jiang, Su-Ying Yan
The broad spectrum antibiotic tigecycline shows promising efficacy against many multiple drug resistant (MDR) pathogens. However, its clinical efficacy in the treatment of hospital-acquired pneumonia (HAP) is unclear. Several studies have reported on the treatment failures of tigecycline monotherapy, suggesting that it may not be sufficient to control severe infections. Combination therapy has become an option to treat MDR bacterial infections. We conducted a literature search using PubMed, Cochrane Library, Embase, Elsevier and the Web of Knowledge databases up to 29 February 2017 to identify relevant published studies...
February 6, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29404396/auto-commentary-on-targeting-mitochondrial-oxidative-phosphorylation-eradicates-therapy-resistant-chronic-myeloid-leukemia-stem-cells
#11
Lucie de Beauchamp, Pablo Baquero, Elodie M Kuntz, Eyal Gottlieb, G Vignir Helgason
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models.
2018: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/29387342/efficacy-of-intravenous-plus-intrathecal-intracerebral-ventricle-injection-of-polymyxin-b-for-post-neurosurgical-intracranial-infections-due-to-mdr-xdr-acinectobacter-baumannii-a-retrospective-cohort-study
#12
Sijun Pan, Xiaofang Huang, Yesong Wang, Li Li, Changyun Zhao, Zhongxiang Yao, Wei Cui, Gensheng Zhang
Background: Post-neurosurgical intracranial infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii are difficult to treat and associated with high mortality. In this study, we analyzed the therapeutic efficacy of intravenous combined with intrathecal/intracerebral ventricle injection of polymyxin B for this type of intracranial infection. Methods: This retrospective study was conducted from January 2013 to September 2017 at the Second Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou,China) and included 61 cases for which cerebrospinal fluid (CSF) cultures were positive for multidrug-resistant or extensively drug-resistant A...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29386360/therapeutic-synergy-between-tigecycline-and-venetoclax-in-a-preclinical-model-of-myc-bcl2-double-hit-b-cell-lymphoma
#13
Micol Ravà, Aleco D'Andrea, Paola Nicoli, Ilaria Gritti, Giulio Donati, Mirko Doni, Marco Giorgio, Daniela Olivero, Bruno Amati
High-grade B cell lymphomas with concurrent activation of the MYC and BCL2 oncogenes, also known as double-hit lymphomas (DHL), show dismal prognosis with current therapies. MYC activation sensitizes cells to inhibition of mitochondrial translation by the antibiotic tigecycline, and treatment with this compound provides a therapeutic window in a mouse model of MYC-driven lymphoma. We now addressed the utility of this antibiotic for treatment of DHL. BCL2 activation in mouse Eμ-myc lymphomas antagonized tigecycline-induced cell death, which was specifically restored by combined treatment with the BCL2 inhibitor venetoclax...
January 31, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29384877/acute-appendicitis-complicated-with-necrotizing-fasciitis-in-a-patient-with-adult-onset-still-s-disease-a-case-report
#14
Zheng-Hao Huang, Yu-Chen Chiu, Li-Lu Ho, Hsiu-Lung Fan, Chun-Chi Lu
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. PATIENT CONCERNS: A previously healthy 65-year-old man with history of AOSD was referred to our hospital for persistent right lower quadrant abdominal pain for 2 days...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29363242/the-outcome-of-patients-with-severe-and-severe-complicated-clostridium-difficile-infection-treated-with-tigecycline-combination-therapy-a-retrospective-observational-study
#15
Emma Jane Bishop, Ravindranath Tiruvoipati, Julie Metcalfe, Catherine Marshall, John Botha, Peter G Kelley
BACKGROUND: Tigecycline is a third-line therapy for severe Clostridium difficile infection (CDI) in Australasian guidelines. Differences in strain types make it difficult to extrapolate international tigecycline efficacy data with combination or monotherapy to Australian practice, where experience is limited. AIMS: To evaluate the efficacy and adverse effects associated with tigecycline combination therapy for severe and severe-complicated CDI in an Australian health care setting...
January 24, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29358291/population-pharmacokinetics-of-high-dose-tigecycline-in-patients-with-sepsis-or-septic-shock
#16
Agnieszka Borsuk-De Moor, Elżbieta Rypulak, Beata Potręć, Paweł Piwowarczyk, Michał Borys, Justyna Sysiak, Dariusz Onichimowski, Grzegorz Raszewski, Mirosław Czuczwar, Paweł Wiczling
Background and objective: Tigecycline is a glycylcycline often used in critically ill patients as antibiotic of last resort. The pharmacokinetics (PK) of tigecycline in Intensive Care Unit (ICU) patients can be affected by severe pathophysiological changes so that standard dosing might not be adequate. The aim of this study was to describe population PK of high dose tigecycline in patients with sepsis or septic shock and evaluate relationship between individual PK parameters and patient's covariates.Materials and Methods: The study population consisted of 37 adult ICU patients receiving 200 mg loading dose of tigecycline followed by multiple doses of 100 mg every 12 h...
January 22, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29338931/in-vitro-activity-of-eravacycline-against-2213-gram-negative-and-2424-gram-positive-bacterial-pathogens-isolated-in-canadian-hospital-laboratories-canward-surveillance-study-2014-2015
#17
George G Zhanel, Melanie R Baxter, Heather J Adam, Joyce Sutcliffe, James A Karlowsky
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute broth microdilution method. The concentration of eravacycline inhibiting 90% of isolates (MIC90) ranged from 0.5 to 2μg/mL for 9 species of Enterobacteriaceae tested (n=2067). Eravacycline activity was largely unaffected by extended-spectrum β-lactamase phenotypes in Escherichia coli (n=141) and Klebsiella pneumoniae (n=21)...
December 22, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29319497/comparison-of-the-treatment-efficacy-between-tigecycline-plus-high-dose-cefoperazone-sulbactam-and-tigecycline-monotherapy-against-ventilator-associated-pneumonia-caused-by-extensively-drug-resistant-acinetobacter-baumannii
#18
Youfa Qin, Jie Zhang, Lei Wu, Dailong Zhang, Lunjiao Fu, Xiaoyan Xue
OBJECTIVE: The present study examined the effect of high-dose cefoperazone-sulbactam combined with tigecycline against ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). MATERIALS AND METHODS: 42 patients with VAP due to XDR-AB infection were randomized into two groups: the TIG group (received tigecycline injection) and the TIG+CFS group (received tigecycline and cefoperazone-sulbactam (1 : 1) injection)...
January 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29319271/sinus-node-dysfunction-a-rare-side-effect-of-tigecyclin
#19
Mukta Agarwal, Divendhu Bhushan
No abstract text is available yet for this article.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29316830/use-of-monte-carlo-simulation-to-evaluate-the-efficacy-of-tigecycline-and-minocycline-for-the-treatment-of-pneumonia-due-to-carbapenemase-producing-klebsiella-pneumoniae
#20
Wentao Ni, Guobao Li, Jin Zhao, Junchang Cui, Rui Wang, Zhancheng Gao, Youning Liu
BACKGROUND: Pneumonia caused by carbapenemase-producing Klebsiella pneumoniae (CP-KP) are increasingly encountered in hospitals worldwide, causing high mortality due to lack of treatment options. The goal of this study was to assess the efficacy of tigecycline and minocycline for CP-KP hospital-acquired pneumonia (HAP) by using Monte Carlo simulation. METHODS: A total of 164 non-duplicated CP-KP strains were collected from sputum or blood in patients with HAP. The MICs for antimicrobials were determined by the agar dilution method...
January 9, 2018: Infectious Diseases
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