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https://www.readbyqxmd.com/read/29031650/tigecycline-based-prolonged-salvage-therapy-in-patients-presenting-with-complex-bone-and-joint-infection
#1
J Wach, A Dinh, H Dutronc, O R Sipahi, A Candevir, F Valour, V Zeller, S Lustig, F Laurent, C Chidiac, T Ferry
OBJECTIVES: To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS: Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS: Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most frequently isolated bacteria were Enterobacteriaceae and staphylococci. Tigecycline (50mg BID, mainly in combination (69...
October 12, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29031431/implementing-an-antibiotic-stewardship-program-at-a-long-term-acute-care-hospital-in-detroit-michigan
#2
Ammara Mushtaq, Reda A Awali, Suganya Chandramohan, Amar Krishna, Caitlin Biedron, Olufemi Jegede, Teena Chopra
BACKGROUND: The objective of the study was to assess health care providers' (HCPs) knowledge and attitude toward antimicrobial resistance (AMR) and implement an antimicrobial stewardship program (ASP) in a long-term acute care hospital (LTACH). METHODS: A questionnaire on antibiotic use and resistance was administered to HCP in an LTACH in Detroit, Michigan, between August 2011 and October 2011. Concurrently, a retrospective review of common antibiotic prescription practices and costs was conducted...
October 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29030448/prevalence-and-antimicrobial-resistance-of-enterococci-isolated-from-retail-meats-in-the-united-states-2002-2014
#3
Gregory H Tyson, Epiphanie Nyirabahizi, Emily Crarey, Claudine Kabera, Claudia Lam, Crystal Rice-Trujillo, Patrick F McDermott, Heather Tate
Bacteria of the genus Enterococcus are important human pathogens that are frequently resistant to a number of clinically important antibiotics. They are also used as a marker of animal fecal contamination of human foods, and are employed as sentinel organisms for tracking trends in resistance to antimicrobials with gram-positive activity. As part of the National Antimicrobial Resistance Monitoring System (NARMS), we evaluated several retail meat commodities for the presence of enterococci from 2002-2014, finding 92...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29026871/tigecycline-as-a-second-line-agent-for-legionnaires-disease-in-severely-ill-patients
#4
Deepika Slawek, Diana Altshuler, Yanina Dubrovskaya, Eddie Louie
Treatment of Legionnaires' disease in severely ill or immunosuppressed patients presents a clinical challenge. Tigecycline (TG) achieves high concentrations intracellularly and has been shown to be effective against L. pneumophila in animal and cell models. We report our experience using TG as second-line therapy. Clinical response was seen in most patients after switching to TG alone or as a combination therapy.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29021722/bacterial-and-antimicrobial-susceptibility-profile-and-the-prevalence-of-sepsis-among-burn-patients-at-the-burn-unit-of-cipto-mangunkusumo-hospital
#5
A Wardhana, R Djan, Z Halim
Infection is a major cause of mortality and morbidity among burn patients. An effective measure to reduce infection is routine monitoring of bacterial infection and antimicrobial susceptibility patterns at the burn unit. This will help to create a burn centre-specific empirical antibiotic therapy protocol. A retrospective, descriptive study was conducted at the Cipto Mangunkusumo Hospital (RSCM) Burn Unit between September-November 2016. Data regarding bacterial culture isolates, antimicrobial susceptibility spectrum, and the number of burn patients diagnosed with sepsis were collected...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29019016/repurposing-zidovudine-in-combination-with-tigecycline-for-treating-carbapenem-resistant-enterobacteriaceae-infections
#6
S M S Ng, J S P Sioson, J M Yap, F M Ng, H S V Ching, J W P Teo, R Jureen, J Hill, C S B Chia
The global emergence of carbapenem-resistant Enterobacteriaceae (CRE) presents a significant clinical concern, prompting the WHO to prioritize CRE as a top priority pathogen in their 2017 global antibiotic-resistant bacteria priority list. Due to the fast-depleting antibiotic arsenal, clinicians are now resorting to using once-abandoned, highly toxic antibiotics such as the polymyxins and aminoglycosides, creating an urgent need for new antibiotics. Drug repurposing, the application of an approved drug for a new therapeutic indication, is deemed a plausible solution to this problem...
October 10, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29017452/whole-genome-sequencing-for-the-molecular-characterization-of-carbapenem-resistant-klebsiella-pneumoniae-strains-isolated-at-the-italian-asst-fatebenefratelli-sacco-hospital-2012-2014
#7
Sara Giordana Rimoldi, Bernardina Gentile, Cristina Pagani, Annamaria Di Gregorio, Anna Anselmo, Anna Maria Palozzi, Antonella Fortunato, Valentina Pittiglio, Anna Lisa Ridolfo, Maria Rita Gismondo, Giuliano Rizzardini, Florigio Lista
BACKGROUND: The emergence of carbapenem-resistant Klebsiella pneumoniae strains is threatening antimicrobial treatment. METHODS: Sixty-eight carbapenemase-producing K. pneumoniae strains isolated at Luigi Sacco University Hospital-ASST Fatebenefratelli Sacco (Milan, Italy) between 2012 and 2014 were characterised microbiologically and molecularly. They were tested for drug susceptibility and carbapenemase phenotypes, investigated by means of repetitive extra-genic palindromic polymerase chain reaction (REP-PCR), and fully sequenced by means of next-generation sequencing for the in silico analysis of multi-locus sequence typing (MLST), their resistome, virulome and plasmid content, and their core single nucleotide polymorphism (SNP) genotypes...
October 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28981866/outer-membrane-protein-a-contributes-to-antimicrobial-resistance-of-acinetobacter-baumannii-through-the-ompa-like-domain
#8
Hyo Il Kwon, Shukho Kim, Man Hwan Oh, Seok Hyeon Na, Yoo Jeong Kim, Young Ho Jeon, Je Chul Lee
Objectives: Acinetobacter baumannii outer membrane protein A (AbOmpA) is involved in bacterial pathogenesis. However, the role of AbOmpA in the antimicrobial resistance of A. baumannii has not been fully elucidated. This study aimed to investigate the role of the OmpA-like domain of AbOmpA in the antimicrobial resistance of A. baumannii . Methods: The MICs of antimicrobial agents for the WT A. baumannii ATCC 17978, Δ ompA mutant, OmpA-like domain-deleted (amino acids 223-356) AbOmpA mutant and single-copy ompA -complemented strain were determined by the Etest method...
July 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28976340/use-of-tigecycline-for-diabetic-foot-infections
#9
Bilgin Arda, Serhat Uysal, Meltem Taşbakan, Ilgın Yıldırım Şimşir, Murat Öztürk, İlgen Ertam, Ayşe Uysal, Sercan Ulusoy
OBJECTIVE: The aim of this study is to evaluate tigecycline for diabetic foot infections (DFIs). MATERIALS AND METHODS: In this prospective observational study, the investigators included patients who had consultation with the Diabetic Foot Council of Ege University Faculty of Medicine (Izmir, Turkey) between March 2013 and July 2015 and who used tigecycline during their treatment. Treatment success was assessed by design-specific criteria for each evaluation. RESULTS: The study included 105 cases...
September 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28972857/identification-of-carbapenem-resistant-klebsiella-pneumoniae-with-emphasis-on-new-delhi-metallo-beta-lactamase-1-blandm-1-in-bandar-abbas-south-of-iran
#10
Saeed Shoja, Maryam Ansari, Forogh Faridi, Mohsen Azad, Parivash Davoodian, Sedigheh Javadpour, Abbas Farahani, Banafsheh Douzandeh Mobarrez, Afsaneh Karmostaji
BACKGROUND AND OBJECTIVE: The spread of carbapenem-resistant Klebsiella pneumoniae especially blaNDM-1-carrying isolates is a great concern worldwide. In this study we describe the molecular basis of carbapenem-resistant K. pneumoniae in three teaching hospitals at Bandar Abbas, south of Iran. MATERIALS AND METHODS: A total of 170 nonduplicate clinical isolates of K. pneumoniae were investigated. Antimicrobial susceptibility test was performed by disc diffusion method...
October 3, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28972552/tigecycline-resistant-klebsiella-pneumoniae-isolated-from-austrian-river-water
#11
Alexander Hladicz, Clemens Kittinger, Gernot Zarfel
Abstract: Antibiotic-resistant bacteria are spreading worldwide in medical settings but also in the environment. These resistant bacteria illustrate a major health problem in our times, and last-line antibiotics such as tigecycline represent an ultimate therapy option. Reports on tigecycline non-susceptible Enterobacteriaceae are presented with regard to medical settings but are rare with that for the environment. The aim of this study was to characterize two tigecycline non-susceptible Klebsiella pneumoniae isolates from the river Mur, and to question the resistance mechanism...
October 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28970161/the-combined-use-of-tigecycline-with-high-dose-colistin-might-not-be-associated-with-higher-survival-in-critically-ill-patients-with-bacteraemia-due-to-carbapenem-resistant-acinetobacter-baumannii
#12
Tania Amat, Antonio Gutiérrez-Pizarraya, Isabel Machuca, Irene Gracia-Ahufinger, Elena Pérez-Nadales, Álvaro Torre-Giménez, José Garnacho-Montero, José Miguel Cisneros, Julian Torre-Cisneros
OBJECTIVE: To assess the association of survival and treatment with colistin and tigecycline in critically ill patients with carbapenem-resistant A. baumannii bacteraemia. METHODS: An observational cohort study was carried out. Targeted therapy consisted of monotherapy with colistin (9 millions UI/day) or combined therapy with colistin and tigecycline (100 g/day). The primary outcome was 30-day crude mortality. The association between combined targeted therapy and mortality was controlled for empirical therapy with colistin, propensity score of combined therapy and other potential confounding variables in a multivariate Cox regression analysis...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28963358/tigecycline-may-selectively-target-leukemic-stem-cells-in-cml
#13
(no author information available yet)
Tigecycline inhibits mitochondrial oxidative phosphorylation to target leukemic stem cells (LSC).
September 29, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28951106/in-vitro-interaction-of-ceftazidime-avibactam-in-combination-with-different-antimicrobials-against-kpc-producing-klebsiella-pneumoniae-clinical-isolates
#14
Paolo Gaibani, Russell E Lewis, Silvia L Volpe, Maddalena Giannella, Caterina Campoli, Maria Paola Landini, PierLuigi Viale, Maria Carla Re, Simone Ambretti
OBJECTIVES: Combination therapy has been recommended when using ceftazidime-avibactam (CAZ-AVI) for the treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp), but the optimal combination is unknown. Six common antimicrobial agents (ertapenem, imipenem, meropenem, gentamicin, tigecycline, and ciprofloxacin) were evaluated for synergy with the recently approved cephalosporin-β-lactamase inhibitor combination CAZ-AVI in this study. METHODS: Different antimicrobial combinations were tested against 13 KPC-Kp, including CAZ-AVI-susceptible (n=11) and resistant (n=2) clinical isolates...
September 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28951056/antimicrobial-activity-among-gram-positive-and-gram-negative-organisms-collected-from-the-asia-pacific-region-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-comparison-of-2015-results-with-previous-years
#15
Qiwen Yang, Ying-Chun Xu, Pattarachai Kiratisin, Michael J Dowzicky
We report the in vitro activity of tigecycline and comparators against Gram-negative and Gram-positive organisms collected from Asia-Pacific during 2004-2010 and 2015. MICs were determined by broth microdilution using CLSI guidelines. Antimicrobial susceptibility was assessed using CLSI breakpoints, except for tigecycline FDA breakpoints. For Acinetobacter baumannii, multidrug-resistant (MDR) rates were 81.8% in 2015 and 48.5% during 2004-2010. Among Escherichia coli and Klebsiella pneumoniae respectively, rates of extended-spectrum β-lactamase-producers in 2015 were 24...
August 31, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28943993/effectiveness-of-a-glycylcycline-antibiotic-for-reducing-the-pathogenicity-of-superantigen-producing-methicillin-resistant-staphylococcus-aureus-in-burn-wounds
#16
Lauren B Nosanov, Daniel Y Jo, Pranay R Randad, Lauren T Moffatt, Bonnie C Carney, Rachel T Ortiz, Jeffrey W Shupp
Objective: Burn-injured patients are highly susceptible to infectious complications, which are often associated with increased morbidity and mortality. Rates of antibiotic resistance have increased, and resistant species such as methicillin-resistant Staphylococcus aureus provide additional challenges in the form of virulence factors. Proteins can disrupt local healing, leading to systemic immune disruption. To optimize outcomes, treatments that reduce pathogenicity must be identified. This study aims to compare a glycylcycline antibiotic-tigecycline-with clindamycin for effectiveness in treating superantigenic methicillin-resistant Staphylococcus aureus in burn wounds...
2017: Eplasty
https://www.readbyqxmd.com/read/28943144/the-epidemiology-antibiograms-and-predictors-of-mortality-among-critically-ill-patients-with-central-line-associated-bloodstream-infections
#17
Shin-Huei Kuo, Wei-Ru Lin, Jun-You Lin, Chung-Hao Huang, Ya-Ting Jao, Pei-Wen Yang, Jong-Rung Tsai, Wen-Hung Wang, Yen-Hsu Chen, Ching-Tzu Hung, Po-Liang Lu
BACKGROUND/PURPOSE: For high risk of central line-associated bloodstream infections (CLABSIs) in patients of intensive care units (ICUs) and scarcely epidemiology and therapeutic recommendations in Asia, we aimed to evaluate the annual change in epidemiology, antibiogram, and risk factors for 14-day mortality. METHODS: A retrospective study of ICUs patients with CLABSIs at a medical center in Taiwan (2010-2016), where central line care bundle implemented since 2014, by reviewing clinical data, pathogens, and the antibiogram...
September 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28941790/resistance-mechanism-and-clinical-characteristics-of-linezolid-resistant-enterococcus-faecium-a-single-center-study-in-korea
#18
Sun Young Cho, Hye Mee Kim, Doo Ryeon Chung, So Hyun Kim, Hee Jae Huh, Cheol-In Kang, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
OBJECTIVES: This study aimed to determine the prevalence of linezolid-resistant vancomycin-resistant Enterococcus (LR-VRE) and investigate the mechanisms for linezolid resistance with clinical and microbiological characterization. METHODS: All vancomycin-resistant Enterococcus faecium (VREF) isolates from blood and rectal swab cultures during 2012-2015 were tested for linezolid resistance. LR-VREF isolates were tested for antimicrobial susceptibility, genes for glycopeptide resistance, and virulence genes...
September 20, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28929962/-determination-of-in-vitro-susceptibilities-of-brucella-spp-strains-against-11-different-antibacterial-gents-isolated-from-blood-cultures
#19
Recep Keşli, Hüseyin Bilgin, Halim Yılmaz
Brucellosis is a worldwide zoonotic disease and still continuous to be a major public health problem. In this study, it was aimed to identify the Brucella strains to the species level isolated from blood cultures, and to determine the rate of antimicrobial susceptibility against eleven antibacterial agents. A total of 106 Brucella spp. strains were included in the study, which were isolated from blood cultures in University of Health Sciences, Konya Training and Research Hospital, Medical Microbiology Laboratory between January 2011 and June 2013...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28927988/impact-of-experimental-variables-on-the-protein-binding-of-tigecycline-in-human-plasma-as-determined-by-ultrafiltration
#20
Christoph Dorn, Alexander Kratzer, Uwe Liebchen, Michael Schleibinger, Alexandra Murschhauser, Jens Schlossmann, Frieder Kees, Philipp Simon, Martin G Kees
Tigecycline, a tetracycline derivative, shows atypical plasma-protein-binding behavior. The unbound fraction decreases with increasing concentration at therapeutic concentrations. Moreover, uncertainty exists about the magnitude of tigecyline's protein binding in man. Unbound fractions between 2.5 and 35% have been reported in plasma from healthy volunteers, and between 25 and 100 % in patients, respectively. In the present study, the protein binding of tigecycline has been investigated by ultrafiltration using different experimental conditions...
September 16, 2017: Journal of Pharmaceutical Sciences
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