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https://www.readbyqxmd.com/read/29683776/coagulase-negative-staphylococci-isolated-from-human-bloodstream-infections-showed-multidrug-resistance-profile
#1
Silvia H S P Pedroso, Savio H C Sandes, Robledo A T Filho, Alvaro C Nunes, Jose C Serufo, Luiz M Farias, Maria A R Carvalho, Maria R Q Bomfim, Simone G Santos
Coagulase-negative staphylococci (CNS) are important pathogens causing nosocomial infections worldwide with increasing resistance to antimicrobials. The aim of this study was to characterize resistance aspects of CNS isolated from patients with bloodstream infections acquired in hospitals in Belo Horizonte, MG, Brazil. Staphylococcus strains were characterized using repetitive sequence-based polymerase chain reaction (rep-PCR) fingerprinting with (GTG)5 primer. Phenotypic resistance was analyzed using AST-P5085 card (bioMérieuxVitek® )...
April 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29679648/in-vitro-activity-of-tigecycline-and-comparators-against-a-european-collection-of-anaerobes-collected-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t-2010-2016
#2
Arne C Rodloff, Michael J Dowzicky
The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) is a global program that aims to monitor the in vitro antimicrobial activities of current therapeutic agents against clinical isolates. This study presents surveillance data for Gram-positive and Gram-negative anaerobic isolates (N = 7008) collected from nine European countries between 2010 and 2016. Presented in this study are antimicrobial susceptibility data, according to the European Committee for Antimicrobial Susceptibility Testing (EUCAST) breakpoints, and minimum inhibitory concentration (MIC) distributions...
April 18, 2018: Anaerobe
https://www.readbyqxmd.com/read/29675006/the-rapid-emergence-of-tigecycline-resistance-in-bla-kpc-2-harboring-klebsiella-pneumoniae-as-mediated-in-vivo-by-mutation-in-teta-during-tigecycline-treatment
#3
Xiaoxing Du, Fang He, Qiucheng Shi, Feng Zhao, Juan Xu, Ying Fu, Yunsong Yu
Tigecycline is one of the last resort treatments for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. Tigecycline resistance often occurs during the clinical treatment of CRKP, yet its mechanism has still not been clearly elucidated. This study presents an analysis of a tigecycline resistance mechanism that developed in clinical isolates from a 56-year-old female patient infected with CRKP during tigecycline treatment. Consecutive clonal consistent K. pneumoniae isolates were obtained during tigecycline treatment...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29672331/tigecycline-associated-acute-pancreatitis
#4
Sana Akhter, Prathik Krishnan, Pratibha Kaul
No abstract text is available yet for this article.
April 10, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29670380/emerging-treatment-options-for-acute-bacterial-skin-and-skin-structure-infections-focus-on-intravenous-delafloxacin
#5
REVIEW
Elda Righi, Alessia Carnelutti, Antonio Vena, Matteo Bassetti
The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), are limited. Delafloxacin is a novel fluoroquinolone available as intravenous and oral formulations and is characterized by an increased efficacy in acidic environments and activity on bacterial biofilm...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29662260/characterization-of-multidrug-resistant-acinetobacter-ssp-strains-isolated-from-medical-intensive-care-units-in-cali-colombia
#6
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29661874/characterization-of-extensively-or-pandrug-resistant-st147-and-st101-oxa-48-producing-klebsiella-pneumoniae-isolates-causing-bloodstream-infections-in-icu-patients
#7
Kalliope Avgoulea, Vincenzo Di Pilato, Olympia Zarkotou, Samanta Sennati, Leda Politi, Antonio Cannatelli, Katerina Themeli-Digalaki, Tommaso Giani, Athanassios Tsakris, Gian Maria Rossolini, Spyros Pournaras
Carbapenem-resistant Klebsiella pneumoniae cause important healthcare-associated infections worldwide. An outbreak of ST11 OXA-48-producing K. pneumoniae isolates (OXA-48-Kp) occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp recovered from 19 ICU patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. β-lactamase genes were detected by PCR. All isolates were typed by PFGE/MLST and 10 representative isolates by next generation sequencing (NGS)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29661029/antimicrobial-stewardship-program-in-a-greek-hospital-implementing-a-mandatory-prescription-form-and-prospective-audits
#8
Vassiliki Pitiriga, Petros Kanellopoulos, Elsa Kampos, George Panagiotakopoulos, Athanasios Tsakris, George Saroglou
AIM: Antimicrobial stewardship programs (ASPs) are urgently needed for Greek hospitals in order to improve antibiotic usage. PATIENTS & METHODS: An ASP was implemented to a Greek hospital since February 2014. A mandatory order form was introduced for five antimicrobials; colistin, tigecycline, daptomycin, doripenem and linezolid. Prospective audits allowed for feedback to the prescribers without direct prescribing restriction. RESULTS: Antimicrobials' consumption at the baseline year and the 3 years of ASP implementation was 93...
April 17, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29630127/research-and-analysis-of-74-bloodstream-infection-cases-of-acinetobacter-baumannii-and-drug-resistance
#9
H-G Wu, W-S Liu, M Zhu, X-X Li
OBJECTIVE: We aimed at investigating the clinical and bacteriological features and drug resistance of bloodstream infection of Acinetobacter baumannii, so as to provide new evidence for treatment of bloodstream infection of Acinetobacter baumannii. PATIENTS AND METHODS: Statistical analysis was carried out for the clinical and bacteriological features and drug sensitivity of 74 bloodstream infection cases of Acinetobacter baumannii who were admitted to this hospital between July 2016 and June 2017...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29626567/evaluation-of-the-intracellular-activity-of-drugs-against-mycobacterium-abscessus-using-a-thp-1-macrophage-model
#10
Carmen Amelia Molina-Torres, Lorena Taméz-Peña, Jorge Castro-Garza, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
April 4, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29626534/pharmacokinetics-pharmacodynamics-and-drug-transport-and-metabolism-nonlinear-protein-binding-not-what-you-think
#11
REVIEW
Amelia N Deitchman, Ravi Shankar Prasad Singh, Hartmut Derendorf
Nonlinear protein binding is traditionally thought of as an increasing fraction unbound with increasing total drug concentration. In the past several years, research into the protein binding of several tetracyclines has shown that an unexpected and counterintuitive phenomenon has been observed. Specifically, that of decreasing unbound drug fraction with increasing total concentrations of drug over certain concentration ranges. While several studies of tigecycline have shown the importance calcium and its chelation may play in the protein-drug interaction, the potential clinical implications and relevance have not been explored...
April 4, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29625340/environmental-surveillance-and-in-vitro-activity-of-antimicrobial-agents-against-legionella-pneumophila-isolated-from-hospital-water-systems-in-campania-south-italy-a-5-year-study
#12
REVIEW
Ida Torre, Rossella Alfano, Tonia Borriello, Osvalda De Giglio, Carmela Iervolino, Maria Teresa Montagna, Marina Silvia Scamardo, Francesca Pennino
BACKGROUND: Legionellosis' treatment failures have been recently reported showing the possibility of resistance development to traditional therapy, especially in healthcare related disease cases. Environmental impact of antibiotic residues, especially in hospital waters, may act on the resistome of Legionella resulting in developing resistance mechanisms. OBJECTIVES: In this study we investigate the antibiotic susceptibility of environmental Legionella pneumophila (Lpn) strains isolated from hospital water systems in Campania, a region located in Southwest Italy...
April 2, 2018: Environmental Research
https://www.readbyqxmd.com/read/29623443/pharmacokinetic-and-pharmacodynamic-considerations-of-antibiotics-of-last-resort-in-treating-gram-negative-infections-in-adult-critically-ill-patients
#13
REVIEW
Mojdeh S Heavner, Kimberly C Claeys, Anne M Masich, Jeffrey P Gonzales
PURPOSE OF REVIEW: We provide an overview of antimicrobials that are considered last resort for the treatment of resistant gram-negative infections in adult critically ill patients. The role in therapy, pharmacodynamic (PD) goals, and pharmacokinetic (PK) changes in critical illness for aminoglycosides, polymyxins, tigecycline, fosfomycin, and fluoroquinolones are summarized. RECENT FINDINGS: Altered PK in septic patients in the intensive care unit (ICU) is observed with many of our agents of last resort...
April 5, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29618039/in-vitro-synergy-with-fluconazole-plus-doxycycline-or-tigecycline-against-clinical-candida-glabrata-isolates
#14
Randol W Hooper, Deborah S Ashcraft, George A Pankey
Candida species, traditionally viewed as opportunistic agents, are increasingly seen as a cause of infection in hospitalized patients. Treatment options are limited to a few classes of drugs. Increased resistance, especially by Candida glabrata, is problematic. We investigated the interaction between fluconazole and doxycycline or tigecycline, using clinically unique blood culture C. glabrata isolates. Eighteen isolates were screened using an Etest® MIC:MIC synergy method. With the doxycycline plus fluconazole combination, 28% of isolates showed synergy; tigecycline plus fluconazole showed 94% synergy...
March 29, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29617860/whole-genome-sequencing-based-characterization-of-antimicrobial-resistance-in-enterococcus
#15
Gregory H Tyson, Jonathan L Sabo, Crystal Rice-Trujillo, Jacqueline Hernandez, Patrick F McDermott
Whole-genome sequencing (WGS) has transformed our understanding of antimicrobial resistance, yielding new insights into the genetics underlying resistance. To date, most studies using WGS to study antimicrobial resistance have focused on gram-negative bacteria in the family Enterobacteriaceae, such as Salmonella spp. and Escherichia coli, which have well-defined resistance mechanisms. In contrast, relatively few studies have been performed on gram-positive organisms. We sequenced 197 strains of Enterococcus from various animal and food sources, including 100 Enterococcus faecium and 97 E...
March 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29615503/genomic-analysis-of-a-pan-resistant-isolate-of-klebsiella-pneumoniae-united-states-2016
#16
Tom J B de Man, Joseph D Lutgring, David R Lonsway, Karen F Anderson, Julia A Kiehlbauch, Lei Chen, Maroya Spalding Walters, Maria Sjölund-Karlsson, J Kamile Rasheed, Alexander Kallen, Alison Laufer Halpin
Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. Here, we report the genomic characterization of an unusual Klebsiella pneumoniae , nonsusceptible to all 26 antibiotics tested, that was isolated from a U.S. PATIENT: The isolate harbored four known beta-lactamase genes, including plasmid-mediated bla NDM-1 and bla CMY-6 , as well as chromosomal bla CTX-M-15 and bla SHV-28 , which accounted for resistance to all beta-lactams tested...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29615166/phenotypic-identification-frequency-distribution-and-antibiogram-of-carbapenemase-producing-enterobacteriaceae-in-clinical-isolates
#17
Maliha Ansari, Tehmina Munir, Nadia Saad
OBJECTIVE: To differentiate between Ambler class A, B and D of carbapenemase-producing Enterobacteriaceae by using simple phenotypic methods that can be carried out in the laboratory without requiring any specialised techniques. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Department, Army Medical College, NUST, Islamabad, from November 2015 to November 2016. METHODOLOGY: Clinical specimens were subjected to identification of Enterobacteriaceae by colony morphology and API 20 E...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29615129/antimicrobial-susceptibility-pattern-of-staphylococcus-aureus-isolates-from-clinical-specimens-at-kenyatta-national-hospital
#18
Wilfred Gitau, Moses Masika, Moses Musyoki, Beatrice Museve, Titus Mutwiri
OBJECTIVE: To determine antibiotic susceptibility pattern of S. aureus isolates from clinical specimens collected from patients at Kenyatta National Hospital from March 2014-February 2016, and to determine the prevalence and quarterly trends of MRSA throughout the study period. RESULTS: A total of 944 S. aureus isolates were analyzed. High sensitivity of S. aureus was observed for quinupristin/dalfopristin (100%), tigecycline (98.2), imipenem (98%), nitrofurantoin (97...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29614915/preliminary-experience-of-tigecycline-treatment-in-critically-ill-children-with-ventilator-associated-pneumonia
#19
Shupeng Lin, Lingfang Liang, Chenmei Zhang, Sheng Ye
Objective Ventilator-associated pneumonia (VAP) is a life-threatening complication for children who are treated in a paediatric intensive care unit. Tigecycline treatment of children with VAP has not been well studied. This study aimed to describe tigecycline use in children with VAP in a tertiary care hospital. Methods We conducted a retrospective chart review in a tertiary hospital from May 1, 2012 to May 1, 2017. Results Twenty-four children (20 girls) with median age of 8 months (range, 27 days to 6 years and 9 months) were treated with tigecycline...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29614366/contributions-of-ferric-uptake-regulator-fur-to-the-sensitivity-and-oxidative-response-of-acinetobacter-baumannii-to-antibiotics
#20
T O Ajiboye, E Skiebe, G Wilharm
Ferric uptake regulator (Fur) is important in the regulation of bacterial iron metabolism and uptake of Fe from the environment. We evaluated the contribution of fur to the sensitivity and oxidative response of A. baumannii to antibiotics. Deletion of fur increased the sensitivity of A. baumannii AB5075 to colistin, gentamicin, rifampicin and tigecycline. Furthermore, activities of superoxide dismutase and catalase in Δfur mutant decreased significantly compared to the parental strain. Conversely, •O2 - and H2 O2 accumulate in colistin, gentamicin, rifampicin or tigecycline-treated Δfur mutant compared to the parental strain...
March 31, 2018: Microbial Pathogenesis
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