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Mako Tsuji, Tomoki Tanaka, Ryosuke Nagashima, Yuka Sagisaka, Yuko Tousen, Yoriko Nishide, Yoshiko Ishimi, Yukio Ishimi
It has been reported that daidzein and equol stimulate DNA replication and proliferation of MCF-7 cells. However, their molecular mechanisms of action are still unclear. We examined the effects of daidzein and equol on DNA replication of MCF-7 cells, focusing on MCM2-7 proteins, which function as the replicative helicase. In the presence of either 1 μM of daidzein or equol, the number of cells in S-phase, which was determined by detecting bromodeoxyuridine incorporated into replicated DNA, almost doubled...
January 15, 2018: Journal of Biochemistry
Li-Jing Du, Ling Yi, Li-Hong Ye, Yu-Bo Chen, Jun Cao, Li-Qing Peng, Yu-Ting Shi, Qiu-Yan Wang, Yu-Han Hu
A simple and effective method of miniaturized solid-phase extraction (mini-SPE) was developed for the simultaneous purification and enrichment of macrolide antibiotics (MACs) (i.e. azithromycin, clarithromycin, erythromycin, lincomycin and roxithromycin) from honey and skim milk. Mesoporous MCM-41 silica was synthesized and used as sorbent in mini-SPE. Several key parameters affecting the performance of mini-SPE procedure were thoroughly investigated, including sorbent materials, amount of sorbent and elution solvents...
January 3, 2018: Journal of Chromatography. A
H M Moura, N L Gibbons, S A Miller, H O Pastore
Multiple synthetic strategies were performed in order to tether a zirconium-based catalyst to the 2D and 3D molecular sieves for olefin polymerizations. The anchoring of fluorene silane to the mesoporous MCM-41 was performed in order to obtain a stable catalyst for olefin polymerization (1@MCM-41). Using spectroscopic methods, this system was shown to have the metal center locked on a face down conformation with the surface. Also, immobilized zirconium complexes have been prepared on three different types of aminopropyl-modified supports (2@magadiite, 2@MCM-41 and 3@MCM-48)...
January 10, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Giovanna Gomes Lara, Marcelo Fernandes Cipreste, Gracielle Ferreira Andrade, Wellington Marcos da Silva, Edésia Martins Barros de Sousa
Recently, flufenamic acid (FFA) was discovered among fenamates as a free radical scavenger and gap junction blocker; however, its effects have only been studied in cancer cells. Normal cells in the surroundings of a tumor also respond to radiation, although they are not hit by it directly. This phenomenon is known as the bystander effect, where response molecules pass from tumor cells to normal ones, through communication channels called gap junctions. The use of the enhanced permeability and retention effect, through which drug-loaded nanoparticles smaller than 200 nm may accumulate around a tumor, can prevent the local side effect upon controlled release of the drug...
January 9, 2018: Bioengineering
Xiaoliu Wang, Lingjun Zhu, Yincong Liu, Shurong Wang
CO2 as a raw feed combined with renewable hydrogen for the production of useful chemicals and alternative energy products is one of the solutions to environmental and energy problems. In this study, a series of Ni-xCeO2/MCM-41 catalysts with a nickel content of 20wt% were prepared through deposition precipitation method for CO2 methanation. Different characterization methods, including BET, XRD, TEM, SEM, H2-TPR and H2-TPD were applied to help explore the influence mechanism of CeO2 on Ni/MCM-41 in CO2 methanation...
January 3, 2018: Science of the Total Environment
Mostafa Fatholahi, Shahnaz Rostamizadeh, Alimohammad Amani
The present study has developed an efficient and eco-friendly protocol for the synthesis of aryl-14-H-dibenzo[a,j] xanthenes through a one-pot condensation reaction of 2-naphthol and arylaldehydes in aqueous media using the nanocatalytic MCM-41-SO3H under ultrasonic illumination. The suggested route demonstrates very promising properties like higher yields, decrease in the time of reaction (5-10 min), mild and straightforward conditions, low level of toxicity, and inclusion of a cost-efficient and ecofriendly catalyst having considerable reusability...
January 3, 2018: Combinatorial Chemistry & High Throughput Screening
Johan Cedervall, Elise Nonnet, Daniel Hedlund, Lennart Häggström, Tore Ericsson, Mirosław Werwiński, Alexander Edström, Ján Rusz, Peter Svedlindh, Klas Gunnarsson, Martin Sahlberg
The substitutional effects of cobalt in (Fe1-xCox)5PB2 have been studied with respect to crystalline structure and chemical order with X-ray diffraction and Mössbauer spectroscopy. The magnetic properties have been determined from magnetic measurements, and density functional theory calculations have been performed for the magnetic properties of both the end compounds, as well as the chemically disordered intermediate compounds. The crystal structure of (Fe1-xCox)5PB2 is tetragonal (space group I4/mcm) with two different metal sites, with a preference for cobalt atoms in the M(2) position (4c) at higher cobalt contents...
January 3, 2018: Inorganic Chemistry
Samson O Akpotu, Brenda Moodley
In this study, ASM41 (as-synthesised MCM-41), MCM-41, MCM-41 encapsulated with graphene oxide (MCM-41-GO) and reduced graphene oxide (MCM-41-G) were fabricated and utilized in the remediation of acetaminophen and aspirin from water. A surfactant template (cetyltrimethylammonium bromide) was added to ASM41 to make it more hydrophobic and its effects on the remediation of acetaminophen and aspirin from wastewater was studied. To further improve the adsorption capacity of the adsorbent, MCM-41 was encapsulated with GO and G which also aided in easy separation of the adsorbent from the aqueous solution...
December 29, 2017: Journal of Environmental Management
Christopher Kobierzycki, Aleksandra Piotrowska, Krzysztof Latkowski, Maciej Zabel, Ewa Nowak-Markwitz, Marek Spaczynski, Witold Kedzia, Bartosz Pula, Marzenna Podhorska-Okolow, Piotr Dziegiel
BACKGROUND/AIM: It has been shown in many studies that expression of pyruvate kinase (PK) enzyme plays a key role during cellular metabolism. There is evidence that cancer cells manifesting very dynamic proliferation may control their division in various mechanisms, i.a. by expression of PKM2 isoform. The exact role of PKM2 in ovarian cancer (OC) cells and cancer associated fibroblasts (CAFs) have not been elucidated. MATERIALS AND METHODS: The present study was focused on analysis of PKM2 expression in cancer cells and CAFs in 97 OC cases, mostly of serous histological type...
January 2018: Anticancer Research
Penghao Liu, Gaojian Huang, Tong Wei, Jing Gao, Chenglin Huang, Mengwei Sun, Limin Zhu, Weili Shen
Defective autophagy of monocytes or macrophages might result in NLRP3 inflammasome activation and cause vascular metabolic inflammation. However, the mechanism underlying the initiation of the autophagy response to hyperlipidaemia remains unclear. Sirtuin 3 (SIRT3), an NAD-dependent deacetylase, is sensitive to the metabolic status and mediates adaptation responses. In this study, we investigated the role of SIRT3-mediated autophagy in regulating NLRP3 inflammasome activation. We determined that the inhibition of autophagy and the activation of the NLRP3 inflammasome were concomitant with reduced SIRT3 levels both in peripheral blood monocytes from obese humans and in palmitate-treated THP-1 cells...
December 20, 2017: Biochimica et Biophysica Acta
Weirui Chen, Xukai Li, Yiming Tang, Jialu Zhou, Dan Wu, Yin Wu, Laisheng Li
A flexible catalyst, Fe-Cu-MCM-41, was employed to enhance diclofenac (DCF) mineralization and inhibit bromate formation in catalytic ozonation process. Greater TOC removal was achieved in Fe-Cu-MCM-41/O3 process (78%) than those in Fe-MCM-41/O3 (65%), Cu-MCM-41/O3 (73%) and sole ozonation (42%). But it was interesting that both Cu-MCM-41/O3 and Fe-MCM-41/O3 achieved 93% bromate inhibition efficiency, only 71% inhibition efficiency was observed in Fe-Cu-MCM-41/O3. Influence of pH, TBA/NaHSO3 and detection of by-products were conducted to explore the mechanism...
December 16, 2017: Journal of Hazardous Materials
Satoru Mimura, Yumiko Kubota, Haruhiko Takisawa
The minichromosome maintenance (MCM) complex, consisting of six subunits, Mcm2-7, is loaded onto replication origins through loading factors (origin recognition complex [ORC], Cdc6, and Cdt1) and forms an MCM double hexamer that licenses the initiation of DNA replication. Previous studies with Xenopus egg extracts showed that loading factors, especially Cdc6, dissociate from chromatin on MCM loading, but the molecular mechanism and physiological significance remain largely unknown. Using a cell-free system for MCM loading onto plasmid DNA in Xenopus egg extracts, we found that MCM loaded onto DNA prevents DNA binding of the loading factors ORC, Cdc6, and Cdt1...
December 20, 2017: Cell Cycle
Chong Chen, Nengjie Feng, Qirui Guo, Zhong Li, Xue Li, Jing Ding, Lei Wang, Hui Wan, Guofeng Guan
A novel hybrid material constituted of MIL-101(Cr) and mesoporous silica was successfully assembled through an in-situ hydrothermal method. The MCM-41 with well-ordered mesopores acted as the structure-directing agent, which regulated the growth of MIL-101(Cr) crystals along a certain direction and restricted the expansion of framework. Meanwhile, the hydroxyl groups existed in MCM-41 preferentially coordinated with the Cr3+ centers in MOF, followed by the layer-packed arrangement of MIL-101(Cr) nanocrystals on the surface of matrix...
December 5, 2017: Journal of Colloid and Interface Science
Shufang Zhang, Bin Zhang, Haojie Liang, Yequn Liu, Yan Qiao, Yong Qin
The heterogenization of homogeneous metal complex catalysts has attracted great attention. Herein, we report the encapsulation of metal complexes into nanochannels of mesoporous materials by coating metal oxides at/near the pore entrance via diffusion-limited atomic layer deposition (ALD) to produce a "hollow plug". The pore size of the hollow plug is precisely controlled on the sub-nanometer scale by the number of ALD cycles to fit various metal complexes with different molecular sizes. Typically, Co or Ti complexes are successfully encapsulated into the nanochannels of SBA-15, SBA-16 and MCM-41...
December 12, 2017: Angewandte Chemie
Anick Bérard, Jin-Ping Zhao, Irene Shui, Susan Colilla
OBJECTIVES: Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans. METHODS: From a cohort of 289 688 pregnancies in Montreal, Quebec, Canada, from 1998 to 2015, first-trimester leflunomide exposure and other antirheumatic drug exposures were studied for their association with MCM and spontaneous abortions...
December 8, 2017: Annals of the Rheumatic Diseases
Dong Woo Yeom, Bo Ram Chae, Jin Han Kim, Jun Soo Chae, Dong Jun Shin, Chang Hyun Kim, Sung Rae Kim, Ji Ho Choi, Seh Hyon Song, Dongho Oh, Se Il Sohn, Young Wook Choi
In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul® MCM (13.2 mg), Tween® 80 (59.2 mg), Transcutol® P (59.2 mg), and Poloxamer 407 (13.2 mg). In the present study, by using Florite® PS-10 (119.1 mg) and Vivapur® 105 (105.6 mg) as solid carriers, VST-loaded solidified SuSMEDDS (S-SuSMEDDS) granules were successfully developed, which possessed good flow properties and rapid drug dissolution...
November 7, 2017: Oncotarget
Chad Swank, Sattam Almutairi, Ann Medley
Background: Outcome measures typically assess single domains making holistic assessment difficult. Our purpose was to develop a mobility composite measure (MCM) based on four commonly used outcome measures and compare this composite score to the individual measures in patients with neurologic disorders. Methods: We retrospectively reviewed 148 medical records for inclusion of primary neurologic diagnosis and scoring for 5 times sit-to-stand test (5TSST), 10-meter walk test (10MWT), 2-minute walk test (2MWT), and activities-specific balance confidence (ABC) scale...
2017: Rehabilitation Research and Practice
Kian Khodadad, Shirin Karimi, Zahra Esfahani-Monfared, Adnan Khosravi, Bizhan Bandarchi-Chamkhaleh
Minichromosome maintenance complex component 6 (MCM-6) is one of the six proteins of the MCM family, which are involved in the initiation of DNA replication, represents a marker of proliferating cells. The goal of this study was to evaluate the prognostic relevance of the neoplastic cell proliferation rate in patients with Hodgkin's lymphoma (HL). We evaluated the formalin-fixed paraffin-embedded lymph node biopsy specimens from 55 patients by using monoclonal antibody against MCM-6 and compared these findings with clinical data and treatment outcome...
September 2017: Acta Medica Iranica
Ji-Rong Lei, Long-Xiang Xie, Jian Liu
Due to environmental changes and manufacturing errors, uncertainties inherently exist in phononic crystals, especially in the material properties and geometric parameters. To handle the uncertainties with limited information, two different methods are proposed for band structure analysis of phononic crystals with uncertainties. One is the Monte Carlo method (MCM). The main shortcoming of it is the high computational cost. The other is the simplex Chebyshev polynomial expansion (SPCE) method. In addition, the computational efficiency of the SPCE method is much higher...
November 2017: Journal of the Acoustical Society of America
Xiaolai Zhou, Björn Spittau
Microglia are the resident immune cells of the central nervous system (CNS) and respond to a variety of endogenous and exogenous stimuli in order to restore cell and tissue homeostasis. Lipopolysaccharide (LPS) is one of these exogenous stimuli, constitutes a major component of the outer membrane of Gram-negative bacteria, and binds to the microglial pattern recognition receptor Toll-like receptor 4 (TLR4). LPS-induced microglia activation is believed to promote neurodegeneration by release of neurotoxic factors such as interleukin-1β, tumor necrosis factor α, or nitric oxide...
November 29, 2017: Neurotoxicity Research
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