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Xukai Li, Weirui Chen, Yiming Tang, Laisheng Li
Fe-MCM-48 catalyst with a three-dimensional cubic pore structure was directly synthesized via a hydrothermal method, and the mineralization efficiency of diclofenac (DCF) in the catalytic ozonation process (Fe-MCM-48/O3 ) was assessed. X-ray diffraction (XRD), N2 adsorption desorption, transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) characterizations revealed that Fe existed in the framework of MCM-48, and Fe-MCM-48 possessed a large surface area and a highly ordered cubic mesoporous structure, which could accelerate reactants and products diffusion...
May 12, 2018: Chemosphere
Stefan P Tarnawsky, Wen-Mei Yu, Cheng-Kui Qu, Rebecca J Chan, Mervin C Yoder
Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. Somatic mutations in Ptpn11 are the most frequent cause of JMML and they commonly occur in utero . Animal models of mutant Ptpn11 have probed the signaling pathways that contribute to JMML. However, existing models may inappropriately exacerbate MPN features by relying on non-hematopoietic-restricted Cre-loxP strains or transplantations into irradiated recipients. In this study we generate hematopoietic-restricted models of Ptpn11E76K-mediated disease using Csf1r-MCM and Flt3Cre...
April 24, 2018: Oncotarget
U T Uthappa, Varsha Brahmkhatri, G Sriram, Ho-Young Jung, Jingxian Yu, Nikita Kurkuri, Tejraj M Aminabhavi, Tariq Altalhi, Gururaj M Neelgund, Mahaveer D Kurkuri
Diatoms, unicellular photosynthetic algae covered with siliceous cell wall, are also called frustule. These are the most potential naturally available materials for the development of cost-effective drug delivery systems because of their excellent biocompatibility, high surface area, low cost and ease of surface modification. Mesoporous silica materials such as MCM-41 and SBA-15 have been extensively used in drug delivery area. Their synthesis is challenging, time consuming, requires toxic chemicals and are energy intensive, making the entire process expensive and non-viable...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Tanasan Intana, Karin Föttinger, Günther Rupprechter, Paisan Kongkachuichay
Copper species in the structure of Cu/core-shell Al-MCM-41 catalysts prepared by different techniques of Cu loading-substitution (S), ion-exchange (E), and impregnation (I) methods-were tested for NO reduction via a selective catalytic reaction with methane. Cerium was added to enhance the performance of copper. It was found that the 1.5%Ce-SEI-Cu/Al-MCM-41, in which Cu was loaded by all three techniques gave the highest NO conversion of 85% at 500 °C. Based on the results from FT-IR in-situ experiment, the mechanism of SCR-CH4 reaction is proposed...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Yongchao Chi, Junjie Xue, Jiankun Zhuo, Dahu Zhang, Mi Liu, Qiang Yao
Fast pyrolysis is one of the most economical and efficient technologies to convert biomass to bio-oil and valuable chemical products. Co-pyrolysis with hydrogen rich materials such as plastics over zeolite catalysts is one of the significant solutions to various problems of bio-oil such as high oxygen content, low heat value and high acid content. This paper studied pyrolysis of cellulose and polypropylene (PP) separately and co-pyrolysis of cellulose and PP over MCM-41 and Al-MCM-41. The pyrolysis over different heating rates (10K/min, 20K/min, 30K/min) was studied by Thermogravimetry Analysis (TGA) and kinetic parameters were obtained by Coats-Redfern method and isoconversion method...
August 15, 2018: Science of the Total Environment
Shijuan Zhang, Fengli Lu, Xiaoyun Ma, Mingbo Yue, Yanxin Li, Jiammin Liu, Jinmao You
MCM-48 mesoporous silica was functionalized with dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride, a quaternary ammonium salt with a long hydrophobic chain, to prepare a new sorbent for the dispersive solid-phase extraction (DSPE) of seven endocrine disrupting compounds (EDCs) including 4-hexylphenol, 4-octylphenol, 4-nonylphenol, bisphenol A, estrone, 17β-estradiol and estriol in water. A series of differently functionalized MCM-48 materials were also synthesized, and they served as reference materials to study the mechanism...
May 7, 2018: Journal of Chromatography. A
Hong-Qing Cai, Zhi-Jian Cheng, Hai-Peng Zhang, Peng-Fei Wang, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang, Jing-Hai Wan
Minichromosome maintenance proteins (MCMs) play an essential role in DNA replication and other cellular activities. However, their expression levels and clinical value in glioma are unclear. In the present study, we analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas, and found that MCM6 presented high expression and was associated with poor survival. Immunohistochemistry analysis of an independent dataset of 423 glioma tissues confirmed the overexpression of MCM6 protein, especially in glioblastomas (GBMs) with shorter overall survival (OS)...
May 9, 2018: Human Pathology
Mohammad Reza Toosi, Mohammad Reza Sarmasti Emami, Sudeh Hajian
MCM-41 mesopore was prepared by hydrothermal method and used for synthesis of polyaniline/MCM-41 nanocomposite via in situ polymerization. The nanocomposite was blended with polysulfone to prepare mixed matrix membrane in different content of nanocomposite by phase inversion method. Structural and surface properties of the samples were characterized by SEM, XRD, FTIR, AFM, TGA, BET, and zeta potential measurements. Effect of the nanocomposite content on the hydrophilicity, porosity, and permeability of the membrane was determined...
May 11, 2018: Environmental Science and Pollution Research International
Héctor Martínez Pérez-Cejuela, Isabel Ten-Doménech, Jamal El Haskouri, Pedro Amorós, Ernesto F Simó-Alfonso, José Manuel Herrero-Martínez
In this study, mesoporous silica materials (MSMs) with bimodal pore systems (namely, UVM-7), MCM-41 silica, and a commercial silica-based material were evaluated as solid-phase extraction (SPE) sorbents for the isolation of phospholipids (PLs) using phosphatidylcholine as a test compound. Morphological characterization (including TEM, surface, and size pore measurements) of these materials was carried out. The mechanism of interaction of the target analyte with the MSMs was also studied. With regard to the SPE process, several experimental parameters that affect the extraction performance (e...
May 11, 2018: Analytical and Bioanalytical Chemistry
Zhichuan Shen, Hongjun Zhou, Huayao Chen, Hua Xu, Chunhua Feng, Xinhua Zhou
Salicylaldimine-modified mesoporous silica (Sal-MCM-3 and Sal-MCM-9) was prepared through a co-condensation method with different amounts of added salicylaldimine. With the coordination from the salicylaldimine, zinc ions were impregnated on Sal-MCM-3 and Sal-MCM-9. Then, Zn-Sal-MCM-3 and Zn-Sal-MCM-9 were calcined to obtain nano-zinc oxide loaded on mesoporous silica (ZnO-MCM-3 and ZnO-MCM-9). The material structures were systematically studied by Fourier transform infrared spectroscopy (FTIR), N₂ adsorption/desorption measurements, X-ray powder diffraction (XRD), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), ultraviolet diffused reflectance spectrum (UV-vis DRS), and thermogravimetry (TGA)...
May 9, 2018: Nanomaterials
Kyle Frohna, Tejas Deshpande, John Harter, Wei Peng, Bradford A Barker, Jeffrey B Neaton, Steven G Louie, Osman M Bakr, David Hsieh, Marco Bernardi
Methylammonium lead iodide perovskite (MAPbI3 ) exhibits long charge carrier lifetimes that are linked to its high efficiency in solar cells. Yet, the mechanisms governing these unusual carrier dynamics are not completely understood. A leading hypothesis-disproved in this work-is that a large, static bulk Rashba effect slows down carrier recombination. Here, using second harmonic generation rotational anisotropy measurements on MAPbI3 crystals, we demonstrate that the bulk structure of tetragonal MAPbI3 is centrosymmetric with I4/mcm space group...
May 8, 2018: Nature Communications
L Briones, M Andrews, F Pizarro, M Arredondo-Olguín
Obesity is characterized by a chronic inflammatory process, with an increased volume of total adipose tissue, especially visceral, which secretes pro-inflammatory cytokines such as TNF-α and IL-6. Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism. Still there are questions remain regarding the interaction of these factors. Our aim was to study the effect of a macrophage-conditioned medium (MCM) on adipocyte cells challenged with glucose and/or iron...
May 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Ahmet Ulu, Imren Ozcan, Suleyman Koytepe, Burhan Ates
The scope of our research was to prepare the organosilane-modified Fe3 O4 @MCM-41 core-shell magnetic nanoparticles, used for L-ASNase immobilization and explored screening of immobilization conditions such as pH, temperature, thermal stability, kinetic parameters, reusability and storage stability. In this content, Fe3 O4 core-shell magnetic nanoparticles were prepared via co-precipitation method and coated with MCM-41. Then, Fe3 O4 @MCM-41 magnetic nanoparticles were functionalized by (3-glycidyloxypropyl) trimethoxysilane (GPTMS) as an organosilane compound...
May 1, 2018: International Journal of Biological Macromolecules
Ana B A Wallis, Conrad A Nieduszynski
Background: Understanding DNA replication initiation is essential to understand the mis-regulation of replication seen in cancer and other human disorders. DNA replication initiates from DNA replication origins. In eukaryotes, replication is dependent on cell cycle kinases which function during S phase. Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) act to phosphorylate the DNA helicase (composed of mini chromosome maintenance proteins: Mcm2-7) and firing factors to activate replication origins...
2018: Wellcome Open Research
Kaihua Gou, Jingwei Liu, Xue Feng, Hao Li, Yuan Yuan, Chengzhong Xing
Minichromosome maintenance proteins (MCM) played a critical role in replication and cell cycle progression. However, their prognostic roles in cancer remain controversial. Therefore, we performed a meta-analysis to investigate the prognostic value of MCMs in cancers. Totally 31 eligible articles with 7653 cancer patients were included in this meta-analysis. We evaluated the relationship between MCMs expression and overall survival (OS) in various cancer patients by using pooled hazard ratios (HRs) and risk ratios (RRs) with 95% confidence intervals (CIs)...
2018: Journal of Cancer
Coşkun Güzel, Natalia I Govorukhina, G Bea A Wisman, Christoph Stingl, Lennard J M Dekker, Harry G Klip, Harry Hollema, Victor Guryev, Peter L Horvatovich, Ate G J van der Zee, Rainer Bischoff, Theo M Luider
Laser capture microdissection (LCM) allows the capture of cell types or well-defined structures in tissue. We compared in a semi-quantitative way the proteomes from an equivalent of 8,000 tumor cells from patients with squamous cell cervical cancer (SCC, n = 22) with healthy epithelial and stromal cells obtained from normal cervical tissue ( n = 13). Proteins were enzymatically digested into peptides which were measured by high-resolution mass spectrometry and analyzed by "all-or-nothing" analysis, Bonferroni, and Benjamini-Hochberg correction for multiple testing...
April 6, 2018: Oncotarget
Zilong Wu, Xiaodong Chen, Mingsong Wang, Jianwen Dong, Yuebing Zheng
Ultrathin active chiral metamaterials with dynamically tunable and responsive optical chirality enable new optical sensors, modulators and switches. Herein, we develop ultrathin active chiral metamaterials of highly tunable chiroptical responses by inducing tunable near-field coupling in the metamaterials, and exploit the metamaterials as ultrasensitive sensors to detect trace amount of solvent impurities. To demonstrate the active chiral metamaterials mediated by tunable near-field coupling, we design moiré chiral metamaterials (MCMs) as model metamaterials, which consist of two layers of identical Au nanohole arrays stacked upon one another in moiré patterns with a dielectric spacer layer between the Au layers...
April 30, 2018: ACS Nano
Xiaolong Zheng, Meiyu Wang, Qiuping Li
Due to the wide potential application in the fields of sensing, lighting materials, and optical⁻electrical multifunctional devices, rare earth complex hybrid materials have been studied extensively over the past decades. A poly(ionic liquid)/mesoporous-based hybrid system which has been functionalized by the covalently linked europium complexes was reported here. Through surface modification with a coupling agent bearing an vinyl group, MCM-41 was chosen as the carrier matrix for poly(ionic liquids) (PILs) and europium compounds, and based on that, novel luminescent hybrid materials were prepared by confining the ionic liquid and europium complexes into the inorganic Si⁻O frameworks...
April 26, 2018: Materials
Elham Khodaverdi, Mina Ahmadi, Hossein Kamali, Farzin Hadizadeh
Objective: Synthetic Mobil Crystalline Material 41 (MCM-41) as a mesoporous material and functionalized MCM-41 using aminopropyl groups were studied in order to investigate their ability to encapsulate and to control the release of diclofenac sodium and piroxicam. Materials and Methods: MCM-41 was synthesized through sol-gel procedure and functionalized with aminopropyl groups. The physicochemical properties of MCM-41 were studied through particle size analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and carbon-hydrogen-nitrogen analysis...
October 2017: International Journal of Pharmaceutical Investigation
Julia D López, Enbal Shacham, Tawnya Brown
Medical case management (MCM) is a core medical service in The Ryan White HIV/AIDS Program and aims to provide treatment and care for people living with HIV/AIDS by engaging, identifying and eliminating barriers to HIV care. Little research has examined the impact of this intervention; therefore, the purpose of this study was to examine the how MCM affects HIV clinical outcomes. The study took place at a midwestern, outpatient infectious diseases clinic. This study utilized a longitudinal, retrospective study design to analyze to the impact of MCM engagement on HIV clinical outcomes (viral loads, CD4 counts) from 2009 to 2015 as a time-varying predictor...
April 24, 2018: AIDS and Behavior
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