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https://www.readbyqxmd.com/read/27912180/radicals-formed-from-proton-loss-of-carotenoid-radical-cations-a-special-form-of-carotenoid-neutral-radical-occurring-in-photoprotection
#1
A Ligia Focsan, Lowell D Kispert
In an organized assembly in Arabidopsis thaliana plant, proton loss from the radical cation of zeaxanthin (Zea(+)) was found to occur under intense illumination, a possible component in photoprotection. A stable neutral radical is formed because of the favorable proton loss at C4(4') position(s) of the terminal ends of Zea(+) that extends the unpaired spin density distribution (notation Zea(4) or Zea(4') by symmetry). Proton loss from the radical cation of β-carotene (β-car(+)) to available proton acceptors was also detected in a PSII sample upon irradiation...
November 19, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27911884/desorption-of-water-from-hydrophilic-mcm-41-mesopores-positron-annihilation-ftir-and-md-simulation-studies
#2
Priya Maheshwari, D Dutta, T Muthulakshmi, B Chakraborty, N Raje, P K Pujari
The desorption mechanism of water from the hydrophilic mesopores of MCM-41 was studied using positron annihilation lifetime spectroscopy (PALS) and attenuated total reflection Fourier transform infrared spectroscopy supplemented with molecular dynamics (MD) simulation. PALS results indicated that water molecules do not undergo sequential evaporation in a simple layer-by-layer manner during desorption from MCM-41 mesopores. The results suggested that the water column inside the uniform cylindrical mesopore become stretched during desorption and induces cavitation (as seen in the case of ink-bottle type pores) inside it, keeping a dense water layer at the hydrophilic pore wall, as well as a water plug at both the open ends of the cylindrical pore, until the water was reduced to a certain volume fraction where the pore catastrophically empties...
December 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27898365/capillary-electrophoresis-with-online-stacking-in-combination-with-agnps-mcm-41-reinforced-hollow-fiber-solid-liquid-phase-microextraction-for-quantitative-analysis-of-capecitabine-and-its-main-metabolite-5-fluorouracil-in-plasma-samples-isolated-from-cancer
#3
Mehrdad Forough, Khalil Farhadi, Rahim Molaei, Hedayat Khalili, Ramin Shakeri, Asghar Zamani, Amir Abbas Matin
The purpose of this study is the development and validation of a simple, novel, selective and fast off-line microextraction technique combining capillary electrophoresis with in-column field-amplified sample injection (FASI) for the simultaneous determination of capecitabine (CAP) and its active metabolite, 5-Fluorouracil (5-FU), in human plasma. At the moment, there is a lack of using cost-effective CE tool combined with novel miniaturized sample clean-up techniques for analysis of these important anti-cancer agents in plasma samples...
November 18, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27888379/medical-co-morbidities-among-patients-with-severe-mental-illnesses-in-a-community-health-facility-in-nigeria
#4
Victor Olufolahan Lasebikan, Joachim Azegbeobor
To examine prevalence of medical comorbidity (MCM) in schizophrenia (n = 1310) and in bipolar disorder (n = 1307) and the association of high burden of MCM (≥3 MCM) with duration of untreated illness, number of episodes, functioning, poly-medication and lifetime hospitalization for the mental disorder. Participants were recruited from a private psychiatric facility in Ibadan, Nigeria between 2004 and 2013 and enquiry made about the lifetime occurrence of 20 common chronic diseases including common tropical diseases...
November 25, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27886289/hydration-in-silica-based-mesoporous-materials-a-dft-model
#5
Maciej Gierada, Ivan Petit, Jarosław Handzlik, Frederik Tielens
The MCM-41 material is very commonly used as a support for catalysts. However, theoretical investigations are significantly limited due to the lack of appropriate models that well and accurately describe the real material and enable effective computation at the same time. In this work, our aim is to obtain calculable models at the DFT level of MCM-41 which are as close as possible to the real material. In particular the hydration degree has been investigated, and we present and characterize here for the first time a model for the MCM-41 unit cell filled with explicit solvent water molecules...
November 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27865542/high-capacity-hollow-porous-dummy-molecular-imprinted-polymers-using-ionic-liquid-as-functional-monomer-for-selective-recognition-of-salicylic-acid
#6
Haiyan Xiang, Mijun Peng, Hui Li, Sheng Peng, Shuyun Shi
The existence of strong intramolecular hydrogen bond in salicylic acid (SA) weakens its intermolecular hydrogen bonding with functional monomer, then it is a challenge work to fabricate molecularly imprinted polymers (MIPs) for SA recognition with high capacity and good selectivity. Here, hollow porous dummy MIPs (HPDMIPs) were prepared using benzoic acid (BA) as dummy template, ionic liquid (i.e. 1-vinyl-3-methylimidazolium chloride) as functional monomer, and MCM-48 as sacrificial support. Factors that affected adsorption, such as type of template and porogen, mole ratio of template-functional monomer-cross-linker and type of binding solvent, were optimized in detail...
January 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27864938/harms-of-cervical-cancer-screening-in-the-united-states-and-the-netherlands
#7
Dik Habbema, Sheila Weinmann, Marc Arbyn, Aruna Kamineni, Andrew E Williams, Inge McM de Kok, Folkert van Kemenade, Terry S Field, Joost van Rosmalen, Martin Brown
We studied harms related to cervical cancer screening and management of screen-positive women in the United States (US) and the Netherlands. We utilised data from four US integrated health care systems (SEARCH), the US National Health Interview Survey, New Mexico state, the Netherlands national histopathology registry, and included studies on adverse health effects of cervical screening. We compared the number of Papanicolaou (Pap) smear tests, abnormal test results, punch biopsies, treatments, health problems (anxiety, pain, bleeding, and discharge), and preterm births associated with excisional treatments...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27858253/microemulsion-transdermal-formulation-for-simultaneous-delivery-of-valsartan-and-nifedipine-formulation-by-design
#8
Jatin Sood, Bharti Sapra, Ashok K Tiwary
The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of two poorly soluble antihypertensive drugs. Surface response methodology of Box-Behnken design was utilized to evaluate the effect of two oils (Captex 500 - x1 and Capmul MCM - x2) and surfactant (Acrysol EL135 - x3) on response y1 (particle size), y2 (solubility of valsartan), and y3 (solubility of nifedipine). The important factors which significantly affected the responses were identified and validated using ANOVA...
November 17, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27854200/china-s-growing-contribution-to-military-chinese-medicine-2005-2014-a-ten-year-literature-survey
#9
Zheng Gan, Ge-Liang Yang, Yi-Fu Fan, Hong-Yun Chen, Wei Gu, Chang-Quan Ling
OBJECTIVE: In China, people have relied on traditional Chinese medicine (TCM) for thousands of years to keep healthy and treat diseases. TCM also plays an important role in military health services and now forms a new discipline called military Chinese medicine (MCM). However, the type, quality and focus of research articles about MCM have not been reported. The present study was performed to analyze the growing trends of MCM and investigate China's contribution to military health services...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27849061/mitigation-of-radiation-induced-hematopoietic-injury-by-the-polyphenolic-acetate-7-8-diacetoxy-4-methylthiocoumarin-in-mice
#10
Kavya Venkateswaran, Anju Shrivastava, Paban K Agrawala, Ashok Prasad, Namita Kalra, Parvat R Pandey, Kailash Manda, Hanumantharao G Raj, Virinder S Parmar, Bilikere S Dwarakanath
Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents (MCM) to combat radiation-induced lethality. In the present study, we investigated the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to ameliorate radiation-induced hematopoietic damage and the associated mortality following total body irradiation (TBI) in C57BL/6 mice. Administration of DAMTC 24 hours post TBI alleviated TBI-induced myelo-suppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of mice, while bone marrow (BM) cellularity was restored through enhanced proliferation of the stem cells...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27848090/environmental-geochemistry-of-the-abandoned-mamut-copper-mine-sabah-malaysia
#11
Antony van der Ent, Mansour Edraki
The Mamut Copper Mine (MCM) located in Sabah (Malaysia) on Borneo Island was the only Cu-Au mine that operated in the country. During its operation (1975-1999), the mine produced 2.47 Mt of concentrate containing approximately 600,000 t of Cu, 45 t of Au and 294 t of Ag, and generated about 250 Mt of overburden and waste rocks and over 150 Mt of tailings, which were deposited at the 397 ha Lohan tailings storage facility, 15.8 km from the mine and 980 m lower in altitude. The MCM site presents challenges for environmental rehabilitation due to the presence of large volumes of sulphidic minerals wastes, the very high rainfall and the large volume of polluted mine pit water...
November 15, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27847225/mesoporous-silica-nanoparticle-based-enzyme-responsive-system-for-colon-specific-drug-delivery-through-guar-gum-capping
#12
Balmiki Kumar, Senthilguru Kulanthaivel, Animesh Mondal, Smruti Mishra, Biplab Banerjee, Asim Bhaumik, Indranil Banerjee, Supratim Giri
In the global context of increasing colonic diseases, colon specific oral drug delivery systems have shown promise as an effective therapeutic modality. Herein, we developed a mesoporous silica nanoparticle (MSN) based enzyme responsive materials for colon specific drug delivery. We have utilized guar gum, a natural carbohydrate polymer as a capping layer to contain a model drug, such as 5-flurouracil (5FU) within the mesoporous channels of MSN. Analytical characterization including electron microscopy, PXRD, nitrogen sorption, thermogravimetric analysis and FTIR, confirmed that the synthesized MSN with size less than 100nm is of MCM-41type...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27845710/a-digital-lock-in-amplifier-for-use-at-temperatures-of-up-to-200-%C3%A2-c
#13
Jingjing Cheng, Yingjun Xu, Lei Wu, Guangwei Wang
Weak voltage signals cannot be reliably measured using currently available logging tools when these tools are subject to high-temperature (up to 200 °C) environments for prolonged periods. In this paper, we present a digital lock-in amplifier (DLIA) capable of operating at temperatures of up to 200 °C. The DLIA contains a low-noise instrument amplifier and signal acquisition and the corresponding signal processing electronics. The high-temperature stability of the DLIA is achieved by designing system-in-package (SiP) and multi-chip module (MCM) components with low thermal resistances...
November 11, 2016: Sensors
https://www.readbyqxmd.com/read/27837251/mcm7-polymorphisms-associated-with-the-aml-relapse-and-overall-survival
#14
Jin Sol Lee, Hyun Sub Cheong, Youngil Koh, Kwang-Sung Ahn, Hyoung Doo Shin, Sung-Soo Yoon
The minichromosome maintenance complex component 7 (MCM7) encodes a member of MCM complex, which plays a critical role in the initiation of gene replication. Due to the importance of MCM complex, MCM7 gene has been regarded as a candidate gene for cancer development. In the present study, seven MCM7 polymorphisms were genotyped in 344 subjects composed of 103 acute myeloid leukemia (AML) patients and 241 normal controls to examine the possible associations between MCM7 polymorphisms and the risk of AML. MCM7 polymorphisms were not associated with the risk of AML (P > 0...
November 12, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27836746/trf2-recruits-orc-through-trfh-domain-dimerization
#15
Mitsunori Higa, Tatsunori Kushiyama, Seiichiro Kurashige, Daisuke Kohmon, Kouki Enokitani, Satoko Iwahori, Nozomi Sugimoto, Kazumasa Yoshida, Masatoshi Fujita
Telomeres are specialized chromatin structures that prevent the degradation and instability of the ends of linear chromosomes. While telomerase maintains long stretches of the telomeric repeat, the majority of telomeric DNA is duplicated by conventional DNA replication. A fundamental step in eukaryotic DNA replication involves chromatin binding of the origin recognition complex (ORC). In human cells, telomeric repeat binding factor 2 (TRF2) is thought to play a role in the recruitment of ORC onto telomeres...
November 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27829925/diels-alder-reactions-in-confined-spaces-the-influence-of-catalyst-structure-and-the-nature-of-active-sites-for-the-retro-diels-alder-reaction
#16
Ángel Cantín, M Victoria Gomez, Antonio de la Hoz
Diels-Alder cycloaddition between cyclopentadiene and p-benzoquinone has been studied in the confined space of a pure silica zeolite Beta and the impact on reaction rate due to the concentration effect within the pore and diffusion limitations are discussed. Introduction of Lewis or Brønsted acid sites on the walls of the zeolite strongly increases the reaction rate. However, contrary to what occurs with mesoporous molecular sieves (MCM-41), Beta zeolite does not catalyse the retro-Diels-Alder reaction, resulting in a highly selective catalyst for the cycloaddition reaction...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27829026/cross-species-rhesus-cytomegalovirus-infection-of-cynomolgus-macaques
#17
Benjamin J Burwitz, Daniel Malouli, Benjamin N Bimber, Jason S Reed, Abigail B Ventura, Meaghan H Hancock, Luke S Uebelhoer, Amruta Bhusari, Katherine B Hammond, Renee G Espinosa Trethewy, Alex Klug, Alfred W Legasse, Michael K Axthelm, Jay A Nelson, Byung S Park, Daniel N Streblow, Scott G Hansen, Louis J Picker, Klaus Früh, Jonah B Sacha
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of multiple new CMV field isolates derived from two closely related nonhuman primate species, Indian-origin rhesus macaques (RM) and Mauritian-origin cynomolgus macaques (MCM), revealed distinct and tight lineage clustering according to the species of origin, with MCM CMV isolates mirroring the limited genetic diversity of their primate host that underwent a population bottleneck 400 years ago...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27827497/hybrid-materials-based-on-novel-2d-lanthanide-coordination-polymers-covalently-bonded-to-amine-modified-sba-15-and-mcm-41-assembly-characterization-structural-features-thermal-and-luminescence-properties
#18
Jun Wang, Wei Dou, Alexander M Kirillov, Weisheng Liu, Cailing Xu, Ran Fang, Lizi Yang
Three novel 2D coordination polymers [Tb2(μ4-L)2(μ-HL)(μ-HCOO)(DEF)]n (Tb-L), [Eu(μ4-L)(L)(H2O)2]n (Eu-L), and [Nd(μ4-L)(L)(H2O)2]n (Nd-L) were assembled from the corresponding lanthanide(iii) nitrates and 5 methoxy-(4-benzaldehyde)-1,3-benzenedicarboxylic acid (H2L) as a main multifunctional building block bearing carboxylate and aldehyde functional groups, using H2O/DEF {DEF = N,N-diethylformamide} as a reaction medium. The obtained coordination polymers were isolated as stable microcrystalline solids and fully characterized by elemental analysis, FT-IR spectroscopy, TGA, BET, PXRD, and single-crystal X-ray diffraction methods...
November 9, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27824294/anti-oxidant-actions-of-selenium-in-orbital-fibroblasts-a-basis-for-the-effects-of-selenium-in-graves-orbitopathy
#19
Giovanna Rotondo Dottore, Marenza Leo, Giamberto Casini, Francesco Latrofa, Luca Cestari, Stefano Sellari-Franceschini, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marino
Background A recent clinical trial has shown a beneficial effect of the antioxidant agent selenium in Graves' orbitopathy (GO). In order to shed light on the cellular mechanisms on which selenium may act, here we investigated its effects in cultured orbital fibroblasts. Methods Primary cultures of orbital fibroblasts from 6 GO patients and 6 control subjects were established. Cells were treated with H2O2 to induce oxidative stress, after pre-incubation with selenium-(Methyl)selenocysteine (SeMCys). The following assays were performed: glutathione disulfide (GSSG), as a measure of oxidative stress, glutathione peroxidase (GPX) activity, cell proliferation, hyaluronic acid (HA) and pro-inflammatory cytokines...
November 8, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27823917/alternaria-alternata-acts-on-human-monocyte-derived-dendritic-cells-to-mediate-th2-th17-polarisation
#20
A Loghmani, R Raoofi, A Ownagh, N Delirezh
INTRODUCTION: Although the mechanism of asthma is not precisely understood in humans, clinical and epidemiological studies have offered a potential relationship between exposure to environmental fungi, such as Alternaria alternata (A. alternata) and the development and exacerbation of asthma. The aim of this project is to investigate the mechanisms of Th2 responses by A. alternata as a clinically relevant model for the environmental exposure. MATERIALS AND METHODS: Plastic adherent monocytes were cultured with granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4) to convert these cells into Monocyte-derived Dendritic cells (MoDc) and then matured in the presence of Monocyte-Conditioned Medium (MCM) as the control group and MCM+ A...
November 4, 2016: Allergologia et Immunopathologia
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