H4

OBJECTIVES: This study aimed to compare the efficacy of royal jelly (RJ) and its major fatty acid 10-hydroxy-2-decenoic acid (10-HDA) on ischemic stroke-related pathologies using histological and molecular approaches. METHODS: Male rats were subjected to middle cerebral artery occlusion (MCAo) to induce ischemic stroke and were supplemented daily with either vehicle (control group), RJ or 10-HDA for 7 days starting on the day of surgery. On the eighth day, rats were sacrificed and brain tissue and blood samples were obtained to analyze brain infarct volume, DNA damage as well as apoptotic, inflammatory and epigenetic parameters...

Boron compounds have attracted the attention of chemists because of their unique catalytic properties and potential wider material applications. Although group 13 metal compounds, which are based on the bis-(benzoxazol-2-yl)-methane system (Box, ({NCOC6 H4 }2 CH2 )), have been reported in the last several years, boron containing Box compounds were still missing. Now we report their successful syntheses and spectroscopic characterisation in this work. The borane compound [({NCOC6 H3 }2 CH)BH2 ] (1) and haloboranes [({NCOC6 H3 }2 CH)BF2 ] (2), [({NCOC6 H3 }2 CH)BCl2 ] (3) and [({NCOC6 H3 }2 CH)BBr2 ] (4) were characterised in the solid state by single crystal X-ray diffraction and in solution by NMR techniques...

Ethanol steam reforming (ESR) over a Ni/Al2 O3 catalyst prepared by reduction of a NiAl2 O4 spinel is a promising alternative route to produce H2 from biomass. This work deepens into the effect of reaction conditions (450-650 °C, a steam/ethanol (S/E) ratio of 3-9, and a weight space time up to 1.3 h) and evaluates the time on stream evolution of the yields of H2 , gaseous byproducts (CO, CO2 , CH4 , C2 H4 , C2 H4 O), and formed carbon/coke. The results are explained taking into consideration the thermodynamics, the extent of each individual reaction, and the catalyst deactivation...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as H4 R antagonist (pKi 6.2) and therefore the effects and pharmacological efficacy on a DSS-induced mice model of UC were assessed in this work. Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test compound LINS01007 was administered daily i...

Phenanthroline-based ligands with bulky aryl groups flanking the metal binding pocket enabled the synthesis and detailed investigation of ethylene complexes of copper(I), silver(I), and gold(I), including structural data of [{2,9-bis(2,4,6-triisopropylphenyl)-1,10-phenanthroline}M(C2 H4 )][SbF6 ] (M = Cu, Ag, Au), Additionally, a related copper(I)-ethylene complex with a highly fluorinated ligand is also reported. Gold(I) affects the ethylene moiety significantly as evident from the notable upfield coordination shifts of ethylene carbon signals in the NMR and lengthening of the ethylene CC bond length...

Ultramicroporous metal-organic frameworks (MOFs) are demonstrated to be advantageous for the separation and purification of light hydrocarbons such as C2 H2 , C2 H4 , and CH4 . The introduction of transition metal sites with strong π-complexation affinity into MOFs is more effective than other adsorption sites for the selective adsorption of π-electron-rich unsaturated hydrocarbon gases from their mixtures. However, lower coordination numbers make it challenging to produce robust MOFs directly utilizing metal ions with π-coordination activity, such as Cu+ , Ag+ , and Pd2+ ...

We have prepared a bis(compartmental) Mannich base ligand H4 L (1,4,8,11-tetraaza-1,4,8,11-tetrakis(2-hydroxy-3-methoxy-5-methylbenzyl)cyclotetradecane) specifically designed to obtain bis(TMII LnIII ) tetranuclear complexes (TM = transition metal). In this regard, we have succeeded in obtaining three new complexes of the formula [Zn2 (μ-L)(μ-OAc)Dy2 (NO3 )2 ]·[Zn2 (μ-L)(μ-OAc)Dy2 (NO3 )(OAc)]·4CHCl3 ·2MeOH (1) and [TM2 (μ-H2 L)2 (μ-succinate)Ln2 (NO3 )2 ] (NO3 )2 ·2H2 O·6MeOH (TMII = Zn, LnIII = Dy (2); TMII = Co, LnIII = Dy (3))...

Improving the gas separation performance of metal-organic frameworks (MOFs) by crystal downsizing is an important but often overlooked issue. Here, we report three different-sized flexible ZUL-520 MOFs (according to the crystal size from large to small, the three samples are, respectively, named ZUL-520-0, ZUL-520-1, and ZUL-520-2) with the same chemical structure for optimizing trace acetylene (C2 H2 ) removal from acetylene/ethylene (C2 H2 /C2 H4 ) mixture. The three differently sized activated ZUL-520 (denoted as ZUL-520a) exhibited almost identical C2 H2 uptake of 4...

Multi-interpenetrated metal-organic frameworks (MOFs) have exhibited excellent performance in selective adsorption due to the variable post-interspersed flexibility, but the design and control remain challenging. Herein, two anthracene-based ligands, 4,4'-(anthracene-9,10-diyl)dibenzoic acid (H2 L1) and 9,10-di(pyridin-4-yl)anthracene (L2), are used to construct a new three-dimensional 6-fold interpenetrated MOF [Zn(L1)(L2)] n ( NBU-X1 ), which exhibits multiple C-H···π interactions that enhance the structural rigidity, thereby entangling with a C2 H2 /C2 H4 separation performance...

Single atom metal-nitrogen-carbon materials have emerged as remarkably potent catalysts, demonstrating unprecedented potential for the photo-driven reduction of CO2 . Herein, a unique Cu@g-C3 N5 catalyst obtained by cooperation of single atom Cu and nitrogen-rich g-C3 N5 is proposed. The particular CuN diatomic active sites (DAS) in Cu@g-C3 N5 contribute to the formation of highly stable CuOCN adsorption, a key configuration for CO2 activation and CC coupling. The synergistic diatomic active sites interaction is found responsible for the efficient photoreduction of CO2 to C2 H4 which has been demonstrated in our Gibbs free energy calculation and COHP analysis...

Two fluorescent probes, Y1-2 were synthesized from 2-acetonaphthone, 4-acetylbiphenyl, and phenyl hydrazine by Vilsmeier-Haack reaction and Knoevenagel condensation. Their recognition efficacies for N2 H4 were tested by UV-visible absorption spectroscopy and fluorescence emission spectroscopy. The recognition mechanism were studies by density-functional theory calculations, and the effect of pH on N2 H4 recognition was also studied. The results showed that the probe Y1-2 has high selectivity and a low detection limit for N2 H4 , and the recognition of N2 H4 can be accomplished at physiological pH...

A novel strain, MA3_2.13T , was isolated from deep-sea sediment of Madeira Archipelago, Portugal, and characterized using a polyphasic approach. This strain produced dark brown soluble pigments, bronwish black substrate mycelia and an aerial mycelium with yellowish white spores, when grown on GYM 50SW agar. The main respiratory quinones were MK-10(H4 ), MK-10(H6 ) and MK-10(H8 ). Diphosphatidylglycerol, phosphatidylethanolamine, three unidentified phospholipids and two glycophospholipids were identified as the main phospholipids...

Since ethylene (C2 H4 ) is important feedstock in the chemical industry, developing economical and energy-efficient adsorption separation techniques based on ethane (C2 H6 )-selective adsorbents to replace the energy-intensive cryogenic distillation is highly demanded, which however remains a daunting challenge. While previous anionic boron cluster hybrid microporous materials display C2 H4 -selective features, we herein reported that the incorporation of a neutral para -carborane backbone and aliphatic 1,4-diazabicyclo[2...

To systematically investigate the dependence of the initiating group and metal size on polymerization performance, a family of rare-earth metal bis(alkyl)/bis(benzyl)/bis(amide) complexes supported by a monoanionic tridentate amidinate ligand [(2,6- i Pr2 C6 H3 )NC(Ph)N(C6 H4 -2-OMe]- ( HL ) were synthesized and well-characterized. Treatment of rare-earth metal tris(alkyl)/tris(benzyl)/tris(amide) complexes Y(CH2 C6 H4 NMe2 - o )3 or Y(CH2 SiMe3 )3 (THF)2 or Ln[N(SiHMe2 )2 ]3 (THF) x (Ln = Sc, x = 1; Ln = Y, La, Sm, Lu, x = 2) with 1 equiv of HL gave the corresponding mono(amidinate) rare-earth metal bis(alkyl)/bis(benzyl)/bis(amide) complexes [(2,6- i Pr2 C6 H4 )NC(Ph)N(C6 H4 -2-OMe)]Y(CH2 C6 H4 NMe2 - o )2 ( 1 ), [(2,6- i Pr2 C6 H4 )NC(Ph)N(C6 H4 -2-OMe)]Y(CH2 SiMe3 )2 (THF) ( 2 ), and [(2,6- i Pr2 C6 H4 )NC(Ph)N(C6 H4 -2-OMe)]Ln[N(SiHMe2 )2 ]2 (THF) n (Ln = Y, n = 1 ( 3 ); Ln = La, n = 1 ( 4 ); Ln = Sc, n = 0 ( 5 ); Ln = Lu, n = 0 ( 6 ); Ln = Sm, n = 0 ( 7 )) in good isolated yields...

Highly connected molecular building blocks (MBBs) have been demonstrated to play a crucial role in reticular chemistry, particularly in predicting the topologies of metal-organic frameworks. Metal phosphonate clusters exhibit considerable advantages in constructing high-connectivity MBBs, owing to the multiple coordination modes offered by phosphonic ligands. Herein, four metal (M = CoII , MnII ) phosphonocarboxylate frameworks (CoPCF-1,2 and MnPCF-1,2) were successfully prepared under solvothermal conditions by utilizing the phosphonocarboxylic ligand, 4'-phosphonobiphenyl-3,5-dicarboxylic acid (H4 pbpdc), and their structural characterization was performed using single-crystal X-ray diffraction (SCXRD)...

Selenosalicylic acid ( ortho -HSeC6 H4 CO2 H), the heavy element congener of the widely studied thiosalicylic acid, was prepared by reaction of 2-carboxybenzenediazonium chloride (HO2 CC6 H4 N2 + Cl- ) with Na2 Se2 , followed by reduction of the resulting diselenide (SeC6 H4 CO2 H)2 with zinc and acetic acid. The coordination chemistry of the selenosalicylate ligand towards a variety of platinum(ii), palladium(ii), nickel(ii), gold(iii), gold(i), rhodium(iii), iridium(iii) and ruthenium(ii) centres was explored...

BACKGROUND: Camels are important animals in Egypt and other Arab countries on the basis of their economic value and ethnic culture. Escherichia coli is implicated in several gastrointestinal infections and outbreaks worldwide, especially in developing countries. It causes infections that might lead to death. Numerous biological activities, such as antioxidative, antibacterial, anti-diabetic, anti-mutagenic, anti-inflammatory, neuroprotective, and diuretic, are associated with coriander and coriander essential oils...

A low-triggering potential and a narrow-potential window are anticipated to decrease the electrochemical interference and cross talk of electrochemiluminescence (ECL). Herein, by exploiting the low oxidative potential (0.82 V vs Ag/AgCl) of dihydrolipoic acid-capped sliver nanoclusters (DHLA-AgNCs), a coreactant ECL system of DHLA-AgNCs/hydrazine (N2 H4 ) is proposed to achieve efficient and oxidative-reduction ECL with a low-triggering potential of 0.82 V (vs Ag/AgCl) and a narrow-potential window of 0.22 V...

The taxonomic position of three actinobacterial strains, BCCO 10_0061T , BCCO 10_0798T , and BCCO 10_0856T , recovered from bare soil in the Sokolov Coal Basin, Czech Republic, was established using a polyphasic approach. The multilocus sequence analysis based on 100 single-copy genes positioned BCCO 10_0061T in the same cluster as Lentzea waywayandensis , strain BCCO 10_0798T in the same cluster as Lentzea flaviverrucosa , Lentzea californiensis , Lentzea violacea , and Lentzea albidocapillata , and strain BCCO 10_0856T clustered together with Lentzea kentuckyensis and Lentzea alba ...

Small molecule photoswitches capable of toggling between two distinct molecular states in response to light are versatile tools to monitor biological processes, control photochemistry, and design smart materials. In this work, six novel dicyanorhodanine-based pyrrole-containing photoswitches are reported. The molecular design avails both the Z and E isomers from synthesis, where each can be isolated using chromatographic techniques. Inter- and intramolecular hydrogen bonding (H-bonding) interactions available to the E and Z isomers, respectively, uniquely impart thermal stability to each isomer over long time periods...