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https://www.readbyqxmd.com/read/28632690/noninvasive-nuclear-spect-myocardial-blood-flow-quantitation-to-guide-management-for-coronary-artery-disease
#1
Lung-Ching Chen, Bor-Hsin Jong, Sheng-Che Lin, Chi-Tai Ku, Ing-Jou Chen, Yen-Kung Chen, Bailing Hsu
Recently, myocardial blood flow quantitation with dynamic SPECT has been validated to enhance the detection of multivessel coronary artery disease (CAD) and conclude equivocal SPECT myocardial perfusion study. This advance opened an important clinical application to utilize the tool in guiding CAD management for area where myocardial perfusion tracers for PET are unavailable or unaffordable. We present a clinical patient with ongoing recursive angina who underwent multiple nuclear stress tests for a sequence of CAD evaluation in 26 months and demonstrated that SPECT myocardial blood flow quantitation properly guided CAD management to warrant patient outcome...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28623525/comparison-of-czt-spect-and-conventional-spect-for-assessment-of-contractile-function-mechanical-synchrony-and-myocardial-scar-in-patients-with-heart-failure
#2
Dayong Wu, Zongyao Zhang, Rongzheng Ma, Feng Guo, Lei Wang, Wei Fang
AIM: The aim of this study was to compare CZT-SPECT (CZT SPECT) to conventional SPECT (C-SPECT) in the assessment of left ventricular myocardial scar, contractile function, and mechanical synchrony in patients with heart failure (HF). METHODS: Fifty-nine patients with HF who were referred for myocardial perfusion/metabolism imaging were enrolled. All patients underwent resting (99m)Tc-MIBI gated myocardial perfusion imaging using a CZT SPECT camera and a C-SPECT camera, respectively, and (18)F-FDG PET myocardial metabolism imaging within three days...
June 16, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28623512/phosphatidylethanolamine-targeting-for-cell-death-imaging-in-early-treatment-response-evaluation-and-disease-diagnosis
#3
REVIEW
Filipe Elvas, Sigrid Stroobants, Leonie Wyffels
Phosphatidylethanolamine (PE) is one of the most abundant phospholipids in mammalian plasma membranes. In healthy cells, PE resides predominantly in the inner leaflet of the cell membrane. In dead or dying cells on the other hand, PE is externalized to the outer leaflet of the plasma membrane. The exposure of PE on the cell surface has therefore become an attractive target for the molecular imaging of cell death using single-photon emission computed tomography (SPECT) and positron emission tomography (PET)...
June 16, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28621621/indications-technique-and-safety-profile-of-insular-stereoelectroencephalography-electrode-implantation-in-medically-intractable-epilepsy
#4
Soha Alomar, Jeffrey P Mullin, Saksith Smithason, Jorge Gonzalez-Martinez
OBJECTIVE Insular epilepsy is relatively rare; however, exploring the insular cortex when preoperative workup raises the suspicion of insular epilepsy is of paramount importance for accurate localization of the epileptogenic zone and achievement of seizure freedom. The authors review their clinical experience with stereoelectroencephalography (SEEG) electrode implantation in patients with medically intractable epilepsy and suspected insular involvement. METHODS A total of 198 consecutive cases in which patients underwent SEEG implantation with a total of 1556 electrodes between June 2009 and April 2013 were reviewed...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28611426/radioiodination-of-bodipy-and-its-application-to-a-nuclear-and-optical-dual-functional-labeling-agent-for-proteins-and-peptides
#5
Masahiro Ono, Hiroyuki Watanabe, Yuki Ikehata, Ning Ding, Masashi Yoshimura, Kohei Sano, Hideo Saji
In molecular imaging research, the development of multimodal imaging probes has recently attracted much attention. In the present study, we prepared radioiodinated BODIPY and applied it as a nuclear and optical dual functional labeling agent for proteins and peptides. We designed and synthesized [(125)I]BODIPY with a N-hydroxysuccinimide (NHS) ester, and evaluated its utility as a nuclear and fluorescent dual labeling agent for proteins and peptides. In the radioiodination reaction of BODIPY-NHS with [(125)I]NaI, [(125)I]BODIPY-NHS was obtained at a 48% radiochemical yield...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611245/optimization-of-spect-measurement-of-myocardial-blood-flow-with-corrections-for-attenuation-motion-and-blood-binding-compared-to-pet
#6
R Glenn Wells, Brian Marvin, Marlie Poirier, Jennifer M Renaud, Robert A deKemp, Terrence D Ruddy
Myocardial blood flow (MBF) and flow reserve (MFR) measured with positron emission tomography (PET) have clinical value. Single-photon emission computed tomography (SPECT) cameras with solid-state detectors can obtain dynamic images for measurement of MBF and MFR. In this study, SPECT measurements of MBF made using (99m)Tc-tetrofosmin were compared to PET in the same patients. Methods: Thirty-one patients had PET MBF rest-stress studies performed with (82)Rb or (13)N- ammonia within one month of their SPECT...
June 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28604617/targeted-magnetic-nanotheranostics-of-cancer
#7
REVIEW
Irina Belyanina, Olga Kolovskaya, Sergey Zamay, Ana Gargaun, Tatiana Zamay, Anna Kichkailo
Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28595975/brain-molecular-imaging-in-pharmacoresistant-focal-epilepsy-current-practice-and-perspectives
#8
A Verger, S Lagarde, L Maillard, F Bartolomei, E Guedj
This review aims to synthesize all the available data on brain molecular imaging, such as single-photon emission computed tomography (SPECT) and interictal fluorodeoxyglucose positron emission tomography (FDG-PET), in focal epilepsies. SPECT imaging is able to measure regional cerebral blood flow and its major innovation remains its ictal imaging value. On the other hand, FDG-PET, which has higher spatial resolution and lower background activity than SPECT, enables glycolytic metabolism to be identified in interictal states...
June 5, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28585933/neuroimaging-studies-of-gaba-in-schizophrenia-a-systematic-review-with-meta-analysis
#9
REVIEW
A Egerton, G Modinos, D Ferrera, P McGuire
Data from animal models and from postmortem studies suggest that schizophrenia is associated with brain GABAergic dysfunction. The extent to which this is reflected in data from in vivo studies of GABA function in schizophrenia is unclear. The Medline database was searched to identify articles published until 21 October 2016. The search terms included GABA, proton magnetic resonance spectroscopy ((1)H-MRS), positron emission tomography (PET), single photon emission computed tomography (SPECT), schizophrenia and psychosis...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28585034/myocardial-perfusion-imaging-in-women-for-the-evaluation-of-stable-ischemic-heart-disease-state-of-the-evidence-and-clinical-recommendations
#10
Viviany R Taqueti, Sharmila Dorbala, David Wolinsky, Brian Abbott, Gary V Heller, Timothy M Bateman, Jennifer H Mieres, Lawrence M Phillips, Nanette K Wenger, Leslee J Shaw
This document from the American Society of Nuclear Cardiology represents an updated consensus statement on the evidence base of stress myocardial perfusion imaging (MPI), emphasizing new developments in single-photon emission tomography (SPECT) and positron emission tomography (PET) in the clinical evaluation of women presenting with symptoms of stable ischemic heart disease (SIHD). The clinical evaluation of symptomatic women is challenging due to their varying clinical presentation, clinical risk factor burden, high degree of comorbidity, and increased risk of major ischemic heart disease events...
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28578510/trans-falcine-and-contralateral-sub-frontal-electrode-placement-in-pediatric-epilepsy-surgery-technical-note
#11
Jonathan Pindrik, Nguyen Hoang, R Shane Tubbs, Brandon J Rocque, Curtis J Rozzelle
INTRODUCTION: Phase II monitoring with intracranial electroencephalography (ICEEG) occasionally requires bilateral placement of subdural (SD) strips, grids, and/or depth electrodes. While phase I monitoring often demonstrates a preponderance of unilateral findings, individual studies (video EEG, single photon emission computed tomography [SPECT], and positron emission tomography [PET]) can suggest or fail to exclude a contralateral epileptogenic onset zone. This study describes previously unreported techniques of trans-falcine and sub-frontal insertion of contralateral SD grids and depth electrodes for phase II monitoring in pediatric epilepsy surgery patients when concern about bilateral abnormalities has been elicited during phase I monitoring...
June 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28577291/a-czt-based-blood-counter-for-quantitative-molecular-imaging
#12
Romain Espagnet, Andrea Frezza, Jean-Pierre Martin, Louis-André Hamel, Laëtitia Lechippey, Jean-Mathieu Beauregard, Philippe Després
BACKGROUND: Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokinetic modeling of tracer uptake. For this purpose, a new automated tool for the determination of blood activity as a function of time is presented. The device, compact enough to be used on the patient bed, relies on a peristaltic pump for continuous blood withdrawal at user-defined rates...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28572290/the-variability-of-translocator-protein-signal-in-brain-and-blood-of-genotyped-healthy-humans-using-in-vivo-123-i-clinde-spect-imaging-a-test-retest-study
#13
Ling Feng, Per Jensen, Gerda Thomsen, Agnete Dyssegaard, Claus Svarer, Lars V Knudsen, Kirsten Møller, Carsten Thomsen, Jens D Mikkelsen, Denis Guilloteau, Gitte M Knudsen, Lars H Pinborg
(123)I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was to examine the test-retest variability of (123)I-CLINDE binding in healthy subjects. Methods: SPECT scans were acquired over 90 min in 16 healthy controls (9 women, 8 mixed-affinity binders [MABs] and 8 high-affinity binders [HABs] twice with an interval of 35 ± 15 d)...
June 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#14
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28559934/the-current-status-of-spect-or-spect-ct-in-south-korea
#15
REVIEW
Ikdong Yoo, Eun Kyoung Choi, Yong-An Chung
The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used...
June 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28556793/syntheses-of-radioiodinated-pyrimidine-2-4-6-triones-as-potential-agents-for-non-invasive-imaging-of-matrix-metalloproteinases
#16
Hans-Jörg Breyholz, Klaus Kopka, Michael Schäfers, Stefan Wagner
Dysregulated expression or activation of matrix metalloproteinases (MMPs) is observed in many kinds of live-threatening diseases. Therefore, MMP imaging for example with radiolabelled MMP inhibitors (MMPIs) potentially represents a valuable tool for clinical diagnostics using non-invasive single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. This work includes the organic chemical syntheses and in vitro evaluation of five iodinated barbiturate based MMPIs and the selection of derivative 9 for radiosyntheses of isotopologues [(123)I]9 potentially useful for MMP SPECT imaging and [(124)I]9 for MMP PET imaging...
May 30, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28556264/design-of-a-tri-pet-collimator-for-high-resolution-whole-body-mouse-imaging
#17
Frank P DiFilippo
PURPOSE: Tri-PET refers to high-resolution 511-keV emission tomography using a multi-pinhole collimator in conjunction with lower-resolution PET detectors operating in coincidence mode. Tri-PET is unique in that three spatial locations are associated with each event (two detector coordinates and one pinhole location). Spatial resolution and sensitivity are similar to that of 511-keV SPECT and are governed mainly by the collimator design. However because of a third spatial location in Tri-PET, the line of response is overdetermined...
May 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/28554409/imaging-in-parkinson-s-disease
#18
Marios Politis, Gennaro Pagano, Flavia Niccolini
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the loss of nigrostriatal dopaminergic neurons and aggregation of misfolded α-synuclein in Lewy bodies. The underlying mechanisms of neurodegeneration in PD are still unknown, and there are no disease-modifying treatments to slow the neurodegenerative processes. There is an urgent need to identify biomarkers that are able to monitor disease progression and assess the development and efficacy of novel disease-modifying drugs. Over the past years, neuroimaging techniques such as magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET) have provided important advances in our understanding of PD...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28540215/myocardial-flow-reserve-mfr-with-positron-emission-tomography-pet-computed-tomography-ct-clinical-impact-in-diagnosis-and-prognosis
#19
REVIEW
Maria Cecilia Ziadi
In recent years, radionuclide myocardial perfusion imaging (MPI) using positron emission tomography/computed tomography (PET/CT) has emerged as a robust tool for the diagnosis, risk stratification and management of patients with known or established coronary artery disease (CAD). Cardiac PET/CT imaging affords key advantages compared to single photon emission computed tomography (SPECT) that encompass: (I) improved diagnostic accuracy; (II) decreased radiation exposure due to the utilization of short-lived radiopharmaceuticals, and importantly; (III) the ability to quantify noninvasively myocardial blood flow (MBF) in absolute terms, that is in ml per minute per gram of tissue...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28536968/clinical-and-imaging-based-prognostic-factors-in-radioembolisation-of-liver-metastases-from-colorectal-cancer-a-retrospective-exploratory-analysis
#20
Kathy P Willowson, Aimee R Hayes, David L H Chan, Michael Tapner, Elizabeth J Bernard, Richard Maher, Nick Pavlakis, Stephen J Clarke, Dale L Bailey
BACKGROUND: The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [(90)Y]-resin microspheres and to explore possible clinical and imaging derived prognostic factors. METHODS: FDG PET/CT was used to measure response of individual lesions to a measured absorbed dose, derived from post-treatment (90)Y PET imaging. Predicted dose was also derived from planning [(99m)Tc]-MAA SPECT data...
December 2017: EJNMMI Research
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