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https://www.readbyqxmd.com/read/29143354/synthesis-and-biological-properties-of-radiohalogenated-%C3%AE-%C3%AE-disubstituted-amino-acids-for-pet-and-spect-imaging-of-amino-acid-transporters-aats
#1
Mark M Goodman, Weiping Yu, Nashwa Jarkas
Fluorine-18 and iodine-123 labeled non-natural alicyclic and methyl branched disubstituted α,α-amino acids are a diverse and useful class of tumor imaging agents suitable for positron emission tomography (PET) and single photon emission computed tomography (SPECT). These tracers target the increased expression of the cell membrane amino acid transporter systems L, ASC and A exhibited by many human tumor cells. The most established clinical use for these radiolabeled amino acids is imaging primary and recurrent gliomas, and primary, recurrent and metastatic prostate cancer...
November 16, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29135109/18f-fdg-pet-ct-versus-99tcm-mibi-spect-which-is-better-for-detection-of-solitary-pulmonary-nodules
#2
Guoliang Xia, Chuanguo An, Zonghua Ming, Hong Guo, Lihong Liu, Yufeng Li
PURPOSE: To compare the diagnostic value of 99Tcm-MIBI- SPECT and 18F-FDG-PET/CT in differentiating benign from malignant solitary pulmonary nodules (SPNs). METHODS: 170 SPNs were involved in this study (78 with 99Tcm-MIBI-SPECT and 92 with 18F-FDG-PET/CT). Definite diagnosis of SPNs was determined by biopsy. The diagnostic efficiency of 99Tcm-MIBI-SPECT and 18F-FDGPET/ CT in differentiating benign from malignant SPNs was analyzed and compared. RESULTS: Seventy-eight patients with SPNs were examined with 99Tcm-MIBI-SPECT (26 with malignant SPNs and 52 with benign SPNs)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#3
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29116145/cingulate-island-sign-temporally-changes-in-dementia-with-lewy-bodies
#4
Tomomichi Iizuka, Rui Iizuka, Masashi Kameyama
The cingulate island sign (CIS) that reflects sparing of the posterior cingulate cortex (PCC) relative to the precuneus plus cuneus on FDG-PET and brain perfusion SPECT, has been proposed as a feature of dementia with Lewy bodies (DLB). As the CIS is influenced by concomitant Alzheimer's disease (AD)-type neurofibrillary tangle (NFT) pathology, we postulated that the CIS gradually disappears as DLB progresses. To determine temporal changes in the CIS, 24 patients with mild DLB and 7 with prodromal DLB underwent (123)I-IMP-SPECT and MMSE twice at an interval of two years...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114915/radiopharmaceuticals-for-imaging-and-endoradiotherapy-of-neurotensin-receptor-positive-tumors
#5
Simone Maschauer, Olaf Prante
The neurotensin receptors are overexpressed in various tumor types, especially in highly progressive pancreatic tumors. As this cancer has a poor 5-year survival prognosis, there is an urgent need to improve early diagnosis and treatment strategies. This review article provides an overview of the latest developments in radiopharmaceuticals for neurotensin receptor-positive tumors, including peptidic and non-peptidic radiopharmaceuticals, not only for SPECT and PET but also for endoradiotherapy.
November 7, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29108860/fibrosis-imaging-current-concepts-and-future-directions
#6
Maike Baues, Anshuman Dasgupta, Josef Ehling, Jai Prakash, Peter Boor, Frank Tacke, Fabian Kiessling, Twan Lammers
Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suffer from several drawbacks, including their invasive nature, sampling variability and limited spatial information. To overcome these limitations, multiple different imaging tools and technologies have been evaluated over the years, including x-ray imaging, computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
November 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29101165/myocardial-contrast-echocardiography-in-mice-technical-and-physiological-aspects
#7
Melissa Verkaik, Erik van Poelgeest, Rick F J Kwekkeboom, Piet M Ter Wee, Charissa E van den Brom, Marc G Vervloet, Etto C Eringa
Myocardial contrast echocardiography (MCE) offers the opportunity to study myocardial perfusion defects in mice in detail. The value of MCE compared to SPECT, PET and CT consists of high spatial resolution, the possibility of quantification of blood volume and relatively low costs. Nevertheless, a number of technical and physiological aspects should be considered to ensure reproducibility among research groups. The aim of this overview is to describe technical aspects of MCE and the physiological parameters that influence myocardial perfusion data obtained with this technique...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29098376/e-edmund-kim-hyung-jun-im-dong-soo-lee-keon-wook-kang-atlas-and-anatomy-of-pet-mri-pet-ct-and-spect-ct-springer-international-publishing-switzerland-2016-isbn-978-3-319-28650-1
#8
Giuseppe Danilo Di Stasio, Luigi Mansi
No abstract text is available yet for this article.
November 2, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29097943/correlation-of-somatostatin-receptor-2-expression-with-gallium-68-dota-tate-uptake-in-neuroblastoma-xenograft-models
#9
Libo Zhang, Douglass C Vines, Deborah A Scollard, Trevor McKee, Teesha Komal, Milan Ganguly, Trevor Do, Bing Wu, Natasha Alexander, Reza Vali, Amer Shammas, Travis Besanger, Sylvain Baruchel
Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as (68)Ga-DOTA-TATE and (177)Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with (68)Ga-DOTA-TATE uptake and (177)Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft models. We demonstrated variable SSTR2 expression profiles in eight NB cell lines. From micro-PET imaging and autoradiography, a higher uptake of (68)Ga-DOTA-TATE was observed in SSTR2 high-expressing NB xenografts (CHLA-15) compared to SSTR2 low-expressing NB xenografts (SK-N-BE(2))...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097932/high-contrast-pet-imaging-of-grpr-expression-in-prostate-cancer-using-cobalt-labeled-bombesin-antagonist-rm26
#10
Bogdan Mitran, Helge Thisgaard, Ulrika Rosenström, Johan Hygum Dam, Mats Larhed, Vladimir Tolmachev, Anna Orlova
High gastrin releasing peptide receptor (GRPR) expression is associated with numerous cancers including prostate and breast cancer. The aim of the current study was to develop a (55)Co-labeled PET agent based on GRPR antagonist RM26 for visualization of GRPR-expressing tumors. Labeling with (57)Co and (55)Co, stability, binding specificity, and in vitro and in vivo characteristics of (57)Co-NOTA-PEG2-RM26 were studied. NOTA-PEG2-RM26 was successfully radiolabeled with (57)Co and (55)Co with high yields and demonstrated high stability...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097917/post-mortem-leukocyte-scintigraphy-in-juvenile-pigs-with-experimentally-induced-osteomyelitis
#11
Pia Afzelius, Ole Lerberg Nielsen, Svend Borup Jensen, Aage Kristian Olsen Alstrup
We have previously demonstrated that (111)In-labeled autologous leukocyte scintigraphy is able to detect osteomyelitis in living juvenile pigs. In animal research studies, it may well be an advantage if the animals could be scanned after euthanasia. Applying traditional scanning of living animals to euthanized animals will render anaesthesia unnecessary and be ideal for obtaining good and reliable scans for the correct interpretation of imaging afterwards, since the animals do not move. The autologous leukocytes of the pigs were collected, marked with (111)In, and reinjected into the pigs and allowed for homing to the site of infections as usual while the pigs were alive...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29093372/-development-of-spect-probes-for-in-vivo-imaging-of-%C3%AE-amyloid-and-tau-aggregates-in-the-alzheimer-s-disease-brain
#12
Hiroyuki Watanabe
 Alzheimer's disease (AD) is the most common form of irreversible dementia among elderly people. In the postmortem brains of AD patients, the deposition of senile plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles composed of highly phosphorylated tau proteins are two neuropathological hallmarks. Therefore, the in vivo imaging of Aβ and tau aggregates with positron-emission tomography (PET) or single-photon emission computed tomography (SPECT) would promote drug development, early diagnosis, and monitoring of the disease status in AD patients...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29083933/beyond-dose-using-pretherapy-biomarkers-to-improve-dose-prediction-of-outcomes-for-radioimmunotherapy-of-non-hodgkin-lymphoma
#13
Peter L Roberson, Lauren B Smith, Meredith A Morgan, Matthew J Schipper, Scott J Wilderman, Anca M Avram, Mark S Kaminski, Yuni K Dewaraja
INTRODUCTION: Non-Hodgkin Lymphoma patients respond differently to therapy according to inherent biological variations. Pretherapy biomarkers may improve dose-response prediction. MATERIALS AND METHODS: Hybrid single-photon emission computed tomography (SPECT)/computed tomography (CT) three-dimensional imaging at multiple time points plus follow-up positron emission tomography (PET)/CT or CT at 2 and 6 months post therapy were used to fit tumor response to combined biological effect and cell clearance models from which three biological effect response parameters (radiosensitivity, cold effect sensitivity, and proliferation potential) were determined per patient...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29076911/abdominal-splenosis-mimicking-peritoneal-metastasis-in-prostate-specific-membrane-antigen-pet-ct-confirmed-with-selective-spleen-spect-ct
#14
Emre Demirci, Duygu Has Simsek, Levent Kabasakal, Mehmet Mülazimoğlu
Ga-prostate-specific membrane antigen (PSMA) PET/CT is a rapidly evolving diagnostic technique to image prostate cancer. In contrast to the name PSMA, various tissues show Ga-PSMA uptake in PET/CT imaging. We present a case of a 68-year-old man with prostate cancer who underwent Ga-PSMA PET/CT. Along with metastatic lymph nodes, multiple nodular lesions within the peritoneal spaces of all 4 quadrants of the abdomen showed high PSMA expression. Because of a history of splenic rupture, a Tc-labeled heat-denatured erythrocyte scintigraphy and SPECT were performed...
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29076910/optimizing-somatostatin-receptor-imaging-in-patients-with-neuroendocrine-tumors-the-impact-of-99mtc-hynictoc-spect-spect-ct-versus-68ga-dotatate-pet-ct-upon-clinical-management
#15
Jolanta Kunikowska, Valerie Lewington, Leszek Krolicki
AIM: The presence of somatostatin receptors in neuroendocrine tumors allows visualization with radiolabeled somatostatin analogs in vivo. The aim of this prospective study was to compare somatostatin receptor imaging using Tc-HYNICTOC with Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) with respect to sensitivity, specificity, and impact upon clinical decision making. METHODS: Sixty-eight patients (30 men, 38 women; aged 56.4 ± 13.5 years) with disseminated, histologically proven neuroendocrine tumor were enrolled...
December 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29075922/mouse-models-of-neurodegenerative-disease-preclinical-imaging-and-neurovascular-component
#16
Sandra Albanese, Adelaide Greco, Luigi Auletta, Marcello Mancini
Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals. Translational research might contribute to the study of neurodegenerative diseases. The mouse has become a key model for studying disease mechanisms that might recapitulate in part some aspects of the corresponding human diseases. Neurodegenerative disorders are very complicated and multifactorial. This has to be taken in account when testing drugs...
October 26, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29051933/peptide-based-fibrin-targeting-probes-for-thrombus-imaging
#17
Bruno L Oliveira, Peter Caravan
The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques...
October 31, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29041875/-myocardial-perfusion-imaging-modalities-what-do-we-really-see
#18
A A Ansheles, B V Sergienko
Assessment of perfusion, severity of ischemia and the volume of viable myocardium, including single-photon or positron emission tomography (SPECT and PET) is one of the most important stages of examination of patients with ischemic heart disease. However, in recent years "perfusion" prefix was added to other cardiologic modalities (echocardiography, magnetic resonance and computed tomography). Such a terminological uncertainty leads cardiologists to an erroneous evaluation of real possibilities of these methods...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29025988/advanced-methods-for-radiolabelling-nanomedicines-for-multi-modality-nuclear-mr-imaging
#19
Jennifer R Lamb, Jason P Holland
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? Any attempt to answer this question must also address how the physical, chemical, and biological properties of a unified imaging agent can be tailored to ensure that optimum specificity and contrast is achieved simultaneously for both imaging modalities...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28990131/diagnosis-and-management-of-cognitive-and-behavioral-changes-in-dementia-with-lewy-bodies
#20
REVIEW
Babak Tousi
Proper diagnosis of dementia with Lewy bodies (DLB) in clinical practice remains suboptimal as many cases are misdiagnosed, usually as Alzheimer disease (AD) or Parkinson's disease (PD) and, in rare cases, psychosis. Therefore, it is important for patients with dementia to be thoroughly evaluated by a specialist who is familiar with current diagnostic tests and treatment options. New diagnostic criteria from the Dementia with Lewy Bodies Consortium have been developed to increase diagnostic sensitivity for DLB (Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium; McKeith et al...
October 9, 2017: Current Treatment Options in Neurology
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