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https://www.readbyqxmd.com/read/29771718/evaluation-of-drug-effects-on-cerebral-blood-flow-and-glucose-uptake-in-un-anesthetized-and-un-stimulated-rats-application-of-free-moving-apparatus-enabling-to-keep-rats-free-during-pet-spect-tracer-injection-and-uptake
#1
Taku Sugita, Yusuke Kondo, Seigo Ishino, Ikuo Mori, Takashi Horiguchi, Mikako Ogawa, Yasuhiro Magata
OBJECTIVES: The purpose of this study is the development of novel fluorine-18-fluorodeoxyglucose (F-FDG)-PET and Tc-hexamethylpropylene amine oxime (HMPAO) SPECT methods with free-moving apparatus on conscious rats to investigate brain activity without the effects of anesthesia and tactual stimulation. We also assessed the sensitivity of the experimental system by an intervention study using fluoxetine as a reference drug. MATERIALS AND METHODS: A catheter was inserted into the femoral vein and connected to a free-moving cannula system...
May 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29764036/-comparison-of-prognostic-value-of-18-f-fdg-pet-ct-myocardial-metabolism-imaging-and-coronary-collateral-circulation-in-patients-with-cto-lesions
#2
G Y Zhai, J L Wang, Y Y Liu, Y J Zhou
Objective: To evaluate the location, extent of viable myocardial of chronic total coronary occlusions(CTO)lesions by (18)F-FDG PET myocardial metabolism imaging and then compare with coronary collateral circulation(CCC) to evaluate the prognostic evaluation in patients with CTO lesions. Methods: A total of Sixty consecutive patients with CTO lesions referred for viability assessment from April 2016 to April 2017 in Department of Cardiology, Beijing Anzhen Hospital were included in the study. These patients underwent (99m)Tc-sestamibi ECG-gated SPECT rest myocardial perfusion imaging and ECG-gated (18)F-FDG PET/CT myocardial metabolic imaging, as well as coronary arteriography were recruited in this study...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29761296/neuroimaging-in-lewy-body-dementia
#3
REVIEW
Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis
Lewy body dementia (DLB) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65 years. Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive dementias. Current practice involves the use of [123 I]FP-CIT-SPECT, [18 F]FDG PET and [123 I]MIBG molecular imaging to support diagnostic procedures. Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLB-like phenotype, as well as aiding differential diagnosis through illustrating disease-specific patterns of atrophy...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29751831/intravenous-injection-of-allogeneic-umbilical-cord-derived-multipotent-mesenchymal-stromal-cells-reduces-the-infarct-area-and-ameliorates-cardiac-function-in-a-porcine-model-of-acute-myocardial-infarction
#4
Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-Bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li, Jianming Li, Yihu Fang, Jianhua Gao, Zhongchao Han
BACKGROUND: Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injection of allogeneic umbilical cord (UC) MSCs in preclinical models of porcine myocardial infarction. METHODS: Different dosages of allogeneic UC-MSCs or the vehicle [phosphate-buffered saline (PBS)] were delivered intravenously into an acute myocardial infarction (AMI) porcine model twice after coronary ligation...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29751364/ictal-and-interictal-electric-source-imaging-in-presurgical-evaluation-a-prospective-study
#5
Praveen Sharma, Michael Scherg, Lars H Pinborg, Martin Fabricius, Guido Rubboli, Birthe Pedersen, Anne-Mette Leffers, Peter Uldall, Bo Jespersen, Jannick Brennum, Otto Mølby Henriksen, Sándor Beniczky
BACKGROUND: Accurate localization of the epileptic focus is essential for surgical treatment of patients with drug- resistant epilepsy. EEG source imaging (ESI) is increasingly used in presurgical evaluation. However, most previous studies analysed interictal discharges. Prospective studies comparing feasibility and accuracy of interictal (II) and ictal (IC) ESI are lacking. METHODS: We prospectively analysed long-term video EEG recordings (LTM) of patients admitted for presurgical evaluation...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29736155/noninferiority-of-99m-tc-ethylenedicysteine-glucosamine-as-an-alternative-analogue-to-18-f-fluorodeoxyglucose-in-the-detection-and-staging-of-non-small-cell-lung-cancer
#6
Dong Dai, F David Rollo, Jerry Bryant, E Edmund Kim
Objective. 99m Tc-ethylenedicysteine-glucosamine (99m Tc-EC-G) was developed as a potential alternative to 18 F-FDG for cancer imaging. A Phase 2 study was conducted to compare 18 F-FDG PET/CT and 99m Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC). This study was aimed to demonstrate that 99m Tc-EC-G SPECT/CT was not inferior to 18 F-FDG PET/CT in patients with confirmed NSCLC. Methods. Seventeen patients with biopsy proven NSCLC were imaged with 99m Tc-EC-G and 18 F-FDG to detect and stage their cancers...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29729443/positron-emission-tomography-pet-and-single-photon-emission-computed-tomography-spect-imaging-of-macrophages-in-large-vessel-vasculitis-current-status-and-future-prospects
#7
REVIEW
William Febry Jiemy, Peter Heeringa, Jan A A M Kamps, Conny J van der Laken, Riemer H J A Slart, Elisabeth Brouwer
Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, 18 F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of 18 F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#8
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29723846/diagnostic-value-of-nineteen-different-imaging-methods-for-patients-with-breast-cancer-a-network-meta-analysis
#9
Xiao-Hong Zhang, Can Xiao
BACKGROUND/AIMS: We performed a network meta-analysis (NMA) to investigate and compare the diagnostic value of 19 different imaging methods used for breast cancer (BC). METHODS: Cochrane Library, PubMed and EMBASE were searched to collect the relevant literature from the inception of the study until November 2016. A combination of direct and indirect comparisons was performed using an NMA to evaluate the combined odd ratios (OR) and draw the surface under the cumulative ranking curves (SUCRA) of the diagnostic value of different imaging methods for BC...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29720959/role-of-neuroimaging-as-a-biomarker-for-neurodegenerative-diseases
#10
REVIEW
Soichiro Shimizu, Daisuke Hirose, Hirokuni Hatanaka, Naoto Takenoshita, Yoshitsugu Kaneko, Yusuke Ogawa, Hirofumi Sakurai, Haruo Hanyu
It has recently been recognized that neurodegenerative diseases are caused by common cellular and molecular mechanisms including protein aggregation and inclusion body formation. Each type of neurodegenerative disease is characterized by the specific protein that aggregates. In these days, the pathway involved in protein aggregation has been elucidated. These are leading to approaches toward disease-modifying therapies. Neurodegenerative diseases are fundamentally diagnosed pathologically. Therefore, autopsy is essential for a definitive diagnosis of a neurodegenerative disease...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29720565/implementation-of-a-cardiac-pet-stress-program-comparison-of-outcomes-to-the-preceding-spect-era
#11
Stacey Knight, David B Min, Viet T Le, Kent G Meredith, Ritesh Dhar, Santanu Biswas, Kurt R Jensen, Steven M Mason, Jon-David Ethington, Donald L Lappe, Joseph B Muhlestein, Jeffrey L Anderson, Kirk U Knowlton
BACKGROUND: Cardiac positron emission testing (PET) is more accurate than single photon emission computed tomography (SPECT) at identifying coronary artery disease (CAD); however, the 2 modalities have not been thoroughly compared in a real-world setting. We conducted a retrospective analysis of 60-day catheterization outcomes and 1-year major adverse cardiovascular events (MACE) after the transition from a SPECT- to a PET-based myocardial perfusion imaging (MPI) program. METHODS: MPI patients at Intermountain Medical Center from January 2011-December 2012 (the SPECT era, n = 6,777) and January 2014-December 2015 (the PET era, n = 7,817) were studied...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29714716/y-90-spect-ml-image-reconstruction-with-a-new-model-for-tissue-dependent-bremsstrahlung-production-using-ct-information-a-proof-of-concept-study
#12
Hongki Lim, Jeffrey A Fessler, Scott J Wilderman, Allen Fredrick Brooks, Yuni K Dewaraja
While the yield of positrons used in Y-90 PET is independent of tissue media, Y-90 SPECT imaging is complicated by the tissue dependence of bremsstrahlung photon generation. The probability of bremsstrahlung production is proportional to the square of the atomic number of the medium. Hence, the same amount of activity in different tissue regions of the body will produce different numbers of bremsstrahlung photons. Existing reconstruction methods disregard this tissue-dependency, potentially impacting both qualitative and quantitative imaging of heterogeneous regions of the body such as bone with marrow cavities...
May 1, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29714486/melanoma-imaging-using-18-f-labeled-%C3%AE-melanocyte-stimulating-hormone-derivatives-with-positron-emission-tomography
#13
Chengcheng Zhang, Zhengxing Zhang, Kuo-Shyan Lin, Joseph Lau, Jutta Zeisler, Nadine Colpo, David M Perrin, Francois Benard
Melanocortin 1 receptor (MC1R) is specifically expressed in the majority of melanomas, a leading cause of death related to skin cancers. Accurate staging and early detection is crucial in managing melanoma. Based on the α-melanocyte-stimulating hormone (αMSH) sequence, MC1R-targeted peptides have been studied for melanoma imaging, predominately for use with single-photon emission computed tomography (SPECT), with few attempts made for positron emission tomography (PET). 18 F is a commonly used PET isotope due to readily available cyclotron production, pure positron emission and a favorable half-life (109...
May 1, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29700129/regional-myocardial-perfusion-disturbance-in-experimental-chronic-chagas-cardiomyopathy
#14
Luciano F L Oliveira, James T Thackeray, José A Marin Neto, Minna M D Romano, Eduardo E V Carvalho, Jorge Mejia, Denise M Tanaka, Grace K Silva, Douglas R Abdalla, Carlos Malamut, Frank M Bengel, Maria L Higuchi, André Schmidt, Edécio Cunha-Neto, Marcus V Simões
Background: Altered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPD) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters ( n = 34) were infected with 3.5x104 to 105 trypomastigote forms of T. cruzi Y-strain and 6 to 10 months afterwards were submitted to in vivo imaging including: rest 99m Tc-sestamibi SPECT imaging, segmental and global left ventricular (LV) function assessment by using 2D-echocardiogram, and 18 F-FDG PET for evaluation of myocardial viability...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29698545/the-role-of-molecular-imaging-in-assessing-degenerative-parkinsonism-an-updated-review
#15
Nicolas Nicastro, Valentina Garibotto, Pierre R Burkhard
Diagnosing degenerative forms of parkinsonism still relies on a thorough clinical assessment, which in Parkinson's disease involves the presence of an asymmetric bradykinesia with rest tremor and/or rigidity that respond substantially to levodopa. Conversely, atypical forms, including multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, exhibit additional features (cerebellar or pyramidal signs, early postural instability), a poor response to dopamine replacement therapy and a bad prognosis...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29694338/cerebral-hypoperfusion-in-autism-spectrum-disorder
#16
Geir Bjørklund, Janet K Kern, Mauricio A Urbina, Khaled Saad, Amira A El-Houfey, David A Geier, Salvatore Chirumbolo, Mark R Geier, Jyutika A Mehta, Jan Aaseth
Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single‑photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices; thalami; basal ganglia; cingulate cortex; caudate nucleus; the limbic system including the hippocampal area; putamen; substantia nigra; cerebellum; and associative cortices...
2018: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/29694246/development-and-validation-of-rapid-a-patient-specific-monte-carlo-three-dimensional-internal-dosimetry-platform
#17
Abigail E Besemer, You Ming Yang, Joseph J Grudzinski, Lance T Hall, Bryan P Bednarz
This work describes the development and validation of a patient-specific Monte Carlo internal dosimetry platform called RAPID (Radiopharmaceutical Assessment Platform for Internal Dosimetry). RAPID utilizes serial PET/CT or SPECT/CT images to calculate voxelized three-dimensional (3D) internal dose distributions with the Monte Carlo code Geant4. RAPID's dosimetry calculations were benchmarked against previously published S-values and specific absorbed fractions (SAFs) calculated for monoenergetic photon and electron sources within the Zubal phantom and for S-values calculated for a variety of radionuclides within spherical tumor phantoms with sizes ranging from 1 to 1000 g...
April 25, 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29689381/on-the-use-of-superparamagnetic-hydroxyapatite-nanoparticles-as-an-agent-for-magnetic-and-nuclear-in-vivo-imaging
#18
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
April 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29679489/data-driven-motion-correction-will-replace-motion-tracking-devices-in-molecular-imaging-guided-radiation-therapy-treatment-planning
#19
Adam Kesner, Tinsu Pan, Habib Zaidi
The last decade has seen abundant literature demonstrating the advantages of hybrid imaging modalities combining morphological and molecular imaging in clinical oncology. Commercial systems merging SPECT and CT, PET and CT or PET and MRI are now widely used in the clinic and have had significant impact on patient management. Ultimately, molecular imaging-guided radiotherapy holds the promise of improved definition of tumor target volumes. However, respiratory motion management remains one of the main challenges of this technique...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29675701/incidental-findings-on-hybrid-spect-ct-and-pet-ct-scanners-is-it-time-for-new-training-and-reporting-guidelines
#20
EDITORIAL
Steven Port
No abstract text is available yet for this article.
April 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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