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https://www.readbyqxmd.com/read/29148559/exploring-the-geometric-magnetic-and-electronic-properties-of-hofmann-mofs-for-drug-delivery
#1
Bikash Mandal, Jin Suk Chung, Sung Gu Kang
The geometric, magnetic, and electronic properties and the drug capturing abilities of Hofmann-type metal organic frameworks (MOFs) were examined using theoretical calculations. The detailed theoretical calculations predicted that the Hofmann sheet can have two different conformations, planar and twisted. The Ni-Co sheet was the most stable among the systems studied, whereas the Ni-Fe sheet was the least stable. All of the sheets were magnetic spin semiconductors, having Dirac-like and dispersionless bands, which give rise to a major spatial separation between the charge carriers upon excitation...
November 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29147673/the-regulation-of-snail-on-the-ubiquitin-edge
#2
Qian Yu, Binhua P Zhou, Yadi Wu
Metastasis accounts for a majority of cancer death. One key feature during metastasis is epithelial-mesenchymal transition (EMT), which is regulated by transcription factors such as Snail and Twist. In non-malignant cells, Snail has a short half-life and is degraded via ubiquitination, but its stability is increased in cancer cell. However, the mechanism by which Snail escapes ubiquitination and degradation remains unknown. Recently, we found that Dub3 is a deubiquinase of Snail. Most importantly, we determined that Dub3 responded to extracellular signals such as IL-6, and that the resultant signaling prevented Snail degradation, and promoted cancer growth, invasion, and migration...
2017: Cancer Cell & Microenvironment
https://www.readbyqxmd.com/read/29147478/abdominal-pain-with-a-twist-a-rare-presentation-of-acute-gastric-volvulus
#3
David P Chen, Saqib Walayat, Imran L Balouch, Daniel K Martin, Teresa J Lynch
Acute gastric volvulus is a life threatening condition requiring early diagnosis and aggressive management. Diagnosis of gastric volvulus remains a challenge for clinicians due to variable, non-specific clinical presentation, which requires a high level of suspicion. It should be considered in patients presenting with chest pain and/or epigastric pain, especially in the elderly population. Endoscopic de-rotation could be initially attempted as a therapeutic modality especially in patients who cannot undergo surgery...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146775/synthetic-tangled1-auxin-induced-in-roots9-mutant-phenotype-used-to-assess-tangled1-function
#4
Ricardo Mir, Victoria H Morris, Henrik Buschmann, Carolyn Rasmussen
TANGLED1 (TAN1) and AUXIN-INDUCED-IN-ROOTS 9 (AIR9) are microtubule binding proteins with cortical division site localization in plants. Their function in Arabidopsis thaliana remained unclear because neither tan1 nor air9 single mutants have a strong phenotype. We show that tan1 air9 double mutants have a synergistic phenotype consisting of short, twisted roots that are hypersenstive to a microtubule depolymerizing drug. The tan1 air9 double mutants have significant defects in division plane orientation due to failures in placing the new cell wall at the correct division site...
November 16, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29144765/triazoliptycenes-a-twist-on-iptycene-chemistry-for-regioselective-cross-coupling-to-build-nonstacking-fluorophores
#5
Taewon Kang, Hongsik Kim, Dongwhan Lee
Triazoliptycene fluorophores have been designed and synthesized, in which a three-dimensional propeller-like iptycene motif is employed to suppress intermolecular π-π stacking in the solid state. Key to the success of this modular synthesis is a stereoelectronic bias imposed by the iptycene scaffold, which assists the desired regioselectivity in the C-N cross-coupling step as the last-stage structure diversification from a common precursor.
November 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29144131/twisting-and-tilting-1-1-bis-dialkylphosphino-ferrocene-bound-to-low-valent-tricarbonylmaganese-i-to-i
#6
K Michael Schäfer, Leonie Reinders, Jan Fiedler, Mark R Ringenberg
Recently we had reported the noninnocent behavior of 1,1'-bis(diphenylphosphino)ferrocene (dppf) in Fe(CO)3dppf [Ringenberg et al., Inorg. Chem., 2017, 56, 7501]. Moving to the left in the periodic table, HMn(CO)3(dRpf) where dRpf = dppf (1H) and 1,1'-bis(diisopropylphosphino)ferrocene (dippf) (2H) were synthesized. The hydride ligand was removed by protonation with [(Et2O)2H][B(Ar(F))4] ([B(Ar(F))4](-) = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate), resulting in the rapid evolution of H2 followed by the formation of an Fe→Mn interaction...
November 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29143829/spectral-properties-of-ionic-benzotristhiazole-based-donor-acceptor-nlo-phores-in-polymer-matrices-and-their-one-and-two-photon-cellular-imaging-ability
#7
M Danko, P Hrdlovič, A Martinická, A Benda, M Cigáň
A series of ionic benzotristhiazolium (BTT) push-pull chromophores, with different nitrogen donor groups and different lengths of conjugated bridges, was successfully doped in polar polymer matrices (PVC and PSS). The spectral (photophysical) properties of their low concentration thin polymeric films are compared with those in solution and are discussed in terms of matrix polarity/viscosity influence, specific polymer-chromophore interaction, structure-spectral property relationship and Twisted Intramolecular Charge-Transfer (TICT) state formation...
November 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29142882/incidence-of-apical-crack-formation-and-propagation-during-removal-of-root-canal-filling-materials-with-different-engine-driven-nickel-titanium-instruments
#8
Taha Özyürek, Vildan Tek, Koray Yılmaz, Gülşah Uslu
Objectives: To determine the incidence of crack formation and propagation in apical root dentin after retreatment procedures performed using ProTaper Universal Retreatment (PTR), Mtwo-R, ProTaper Next (PTN), and Twisted File Adaptive (TFA) systems. Materials and Methods: The study consisted of 120 extracted mandibular premolars. One millimeter from the apex of each tooth was ground perpendicular to the long axis of the tooth, and the apical surface was polished...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29140912/reliable-testing-battery-for-assessing-physical-qualities-of-elite-academy-rugby-league-players
#9
Nick Dobbin, Richard Hunwicks, Jamie Highton, Craig Twist
Dobbin, N, Hunwicks, R, Highton, J, and Twist, C. Reliable testing battery for assessing physical qualities of elite academy rugby league players. J Strength Cond Res XX(X): 000-000, 2017-This study assessed the interday reliability of a testing battery for the assessment of physical qualities of rugby league players. Fifty players (age 17.1 ± 1.1 years; stature 181.3 ± 6.3 cm; and body mass 89.0 ± 11.6 kg) from 3 Super League academies participated in this study. Tests of countermovement jump performance, 10- and 20-m sprint performance, change of direction, medicine ball throw, and a modified Yo-Yo Intermittent Recovery Test Level 1 (prone Yo-Yo IR1) were completed on 3 separate occasions...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140283/templated-sphere-phase-liquid-crystals-for-tunable-random-lasing
#10
Ziping Chen, Dechun Hu, Xingwu Chen, Deren Zeng, Yungjui Lee, Xiaoxian Chen, Jiangang Lu
A sphere phase liquid crystal (SPLC) composed of three-dimensional twist structures with disclinations among them exists between isotropic phase and blue phase in a very narrow temperature range, about several degrees centigrade. A low concentration polymer template is applied to improve the thermal stability of SPLCs and broadens the temperature range to more than 448 K. By template processing, a wavelength tunable random lasing is demonstrated with dye doped SPLC. With different polymer concentrations, the reconstructed SPLC random lasing may achieve more than 40 nm wavelength continuous shifting by electric field modulation...
November 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29138449/haemodynamic-recovery-properties-of-the-torsioned-testicular-artery-lumen
#11
Selda Goktas, Ozlem Yalcin, Erhan Ermek, Senol Piskin, Can T Capraz, Yusuf O Cakmak, Kerem Pekkan
Testicular artery torsion (twisting) is one such severe vascular condition that leads spermatic cord injury. In this study, we investigate the recovery response of a torsioned ram testicular artery in an isolated organ-culture flow loop with clinically relevant twisting modes (90°, 180°, 270° and 360° angles). Quantitative optical coherence tomography technique was employed to track changes in the lumen diameter, wall thickness and the three-dimensional shape of the vessel in the physiological pressure range (10-50 mmHg)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138221/immature-cml-cells-implement-a-bmp-autocrine-loop-to-escape-tki-treatment
#12
Elodie Grockowiak, Bastien Laperrousaz, Sandrine Jeanpierre, Thibault Voeltzel, Boris Guyot, Stéphanie Gobert, Franck E Nicolini, Véronique Maguer-Satta
The BCR-ABL specific Tyrosine Kinase Inhibitors (TKI) changed the outcome of Chronic Myeloid Leukemia (CML), turning a life-threatening disease into a chronic illness. However, TKI are not yet curative, since most patients retain leukemic stem cells (LSC) and their progenitors in bone marrow and relapse following treatment cessation. At diagnosis, deregulations of the Bone Morphogenetic Proteins (BMP) pathway are involved in LSC and progenitors expansion. Here, we report that BMP pathway alterations persist in TKI-resistant patients...
November 14, 2017: Blood
https://www.readbyqxmd.com/read/29136474/characterization-of-the-sub-micrometer-hierarchy-levels-in-the-twist-bend-nematic-phase-with-nanometric-helices-via-photopolymerization-explanation-for-the-sign-reversal-in-the-polar-response
#13
Vitaly P Panov, Sithara P Sreenilayam, Yuri Panarin, Jagdish K Vij, Chris Welch, Georg H Mehl
Photo-polymerization of a reactive mesogen mixed with a mesogenic dimer, shown to exhibit the twist-bend nematic phase NTB, reveals the complex structure of the self-deformation patterns observed in planar cells. The polymerized reactive mesogen retains the structure formed by liquid crystalline molecules in the twist bend phase, thus enabling observation by Scanning Electron Microscopy (SEM). Hierarchical ordering scales from tens of nanometers to micrometers are imaged in detail. Submicron features, anticipated from earlier X-ray experiments, are visualized directly...
November 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/29135004/floppy-molecules-as-candidates-for-achieving-optoelectronic-molecular-devices-without-skeletal-rearrangement-or-bond-breaking
#14
Ioan Bâldea
Molecular species investigated as possible candidates for molecular photoswitches often toggle between two (low and high conductance) conformations implying skeletal rearrangement, bond breaking, and substantial changes of molecular length. All these represent shortcomings that impede the switching speed and straightforward incorporation in nanodevices. In the present paper we propose a mechanism wherein the photoinduced switching is from a nonplanar conformation to a planar conformation, and involves neither skeletal rearrangement nor bond breaking or significant molecular length changes...
November 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29134103/allometry-of-wing-twist-and-camber-in-a-flower-chafer-during-free-flight-how-do-wing-deformations-scale-with-body-size
#15
Yonatan Meresman, Gal Ribak
Intraspecific variation in adult body mass can be particularly high in some insect species, mandating adjustment of the wing's structural properties to support the weight of the larger body mass in air. Insect wings elastically deform during flapping, dynamically changing the twist and camber of the relatively thin and flat aerofoil. We examined how wing deformations during free flight scale with body mass within a species of rose chafers (Coleoptera: Protaetia cuprea) in which individuals varied more than threefold in body mass (0...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133405/parallel-magnetic-field-suppresses-dissipation-in-superconducting-nanostrips
#16
Yong-Lei Wang, Andreas Glatz, Gregory J Kimmel, Igor S Aranson, Laxman R Thoutam, Zhi-Li Xiao, Golibjon R Berdiyorov, François M Peeters, George W Crabtree, Wai-Kwong Kwok
The motion of Abrikosov vortices in type-II superconductors results in a finite resistance in the presence of an applied electric current. Elimination or reduction of the resistance via immobilization of vortices is the "holy grail" of superconductivity research. Common wisdom dictates that an increase in the magnetic field escalates the loss of energy since the number of vortices increases. Here we show that this is no longer true if the magnetic field and the current are applied parallel to each other. Our experimental studies on the resistive behavior of a superconducting Mo0...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29131954/ultrafast-wiggling-and-jiggling-ir2-1-8-diisocyanomenthane-4-2
#17
Martin Pizl, Bryan M Hunter, Gregory M Greetham, Michael Towrie, Stanislav Zalis, Harry B Gray, Antonin Vlcek
Binuclear complexes of d8 metals (PtII, IrI, RhI, ) exhibit diverse photonic behavior including dual emission from relatively long-lived singlet and triplet excited states, as well as photochemical energy-, electron-, and atom transfer. Time-resolved optical spectroscopic and X-ray studies have revealed the behavior of the dimetallic core, confirming that M-M bonding is strengthened upon d*p excitation. We report the bridging ligand dynamics of Ir2(1,8-diisocyanomenthane)42+ (Ir(dimen)), investigated by fs-ns time-resolved IR spectroscopy (TRIR) in the region of CN stretching vibrations, (CN), 2000-2300 cm-1...
November 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29131542/the-three-dimensional-structure-of-twisted-benzo-ghi-perylene-triimide-dimer-as-a-non-fullerene-acceptor-for-inverted-perovskite-solar-cells
#18
Priyadharsini Karuppuswamy, Hung-Cheng Chen, Pen-Cheng Wang, Chao-Ping Hsu, Ken-Tsung Wong, Chih Wei Chu
In this work, we introduced benzo[ghi]perylenetriimide (BPTI) derivatives including monomer and twisted dimer (t-BPTI) as an alternative electron transport layer (ETL) material to replace the commonly used PC61BM in inverted planar heterojunction perovskite solar cells. Moreover, the double ETL layer was applied in our perovskite solar cells with structure of glass/ITO/PEDOT:PSS/perovskite/BPTI/C60 or PDI-C4/BCP/Al. Use of a double ETL layer structure can effectively eliminate the leakage current. The devices with the t-BPTI/C60 double ETL layer yield an average power conversion efficiency of 10...
November 12, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29130522/rhoj-promotes-hypoxia-induced-endothelial-to-mesenchymal-transition-by-activating-wdr5-expression
#19
Li Liu, Junliang Chen, Lina Sun
Endothelial-to-mesenchymal transition (EndMT) contributes to the pathogenesis of a host of human diseases. RhoJ, a small G protein, is abundantly expressed in endothelial cells. In the present study we investigated the potential role RhoJ plays in EndMT. We report that RhoJ depletion by small interfering RNA attenuated hypoxia induced EndMT in both immortalized endothelial cells and human primary microvascular endothelial cells. RhoJ knockdown blocked the recruitment of TWIST and SNAIL, two transcriptional repressors, to the promoter region of VE-CADHERIN, a prominent endothelial marker...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29130109/deubiquitinase-usp9x-promotes-cell-migration-invasion-and-inhibits-apoptosis-of-human-pancreatic-cancer
#20
Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Ren
Ubiquitin specific peptidase 9, X-linked (USP9X), a significant regulatory protease in protein ubiquitination, has been proven to act as a proto-oncogene in several types of cancers, such as cervix, colon, breast, brain and lung cancers. The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to its high invasive and metastatic abilities. Nevertheless, whether USP9X acts as a proto-oncogene or a tumor-suppressor gene in PDAC is controversial and the mechanism of metastasis remains unknown...
December 2017: Oncology Reports
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