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https://www.readbyqxmd.com/read/28549347/the-roles-of-ing5-in-gliomas-a-good-marker-for-tumorigenesis-and-a-potential-target-for-gene-therapy
#1
Shuang Zhao, Zhi-Juan Zhao, Hao-Yu He, Ji-Cheng Wu, Xiao-Qing Ding, Lei Yang, Ning Jia, Zhi-Jie Li, Hua-Chuan Zheng
To elucidate the anti-tumor effects and molecular mechanisms of ING5 on glioma cells, we overexpressed it in U87 cells, and examined the phenotypes and their relevant molecules. It was found that ING5 overexpression suppressed proliferation, energy metabolism, migration, invasion, and induced G2/M arrest, apoptosis, dedifferentiation, senescence, mesenchymal- epithelial transition and chemoresistance to cisplatin, MG132, paclitaxel and SAHA in U87 cells. There appeared a lower expression of N-cadherin, Twist, Slug, Zeb1, Zeb2, Snail, Ac-H3, Ac-H4, Cdc2, Cdk4 and XIAP, but a higher expression of Claudin 1, Histones 3 and 4, p21, p53, Bax, β-catenin, PI3K, Akt, and p-Akt in ING5 transfectants...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548955/exploring-brusatol-as-a-new-anti-pancreatic-cancer-adjuvant-biological-evaluation-and-mechanistic-studies
#2
Zheng Lu, Zheng-Quan Lai, Albert W N Leung, Po Sing Leung, Zhao-Shen Li, Zhi-Xiu Lin
Pancreatic cancer is highly resistant to chemotherapeutic agents and is known to have a poor prognosis. The development of new therapeutic entities is badly needed for this deadly malignancy. In this study, we demonstrated for the first time that brusatol, a natural quassinoid isolated from a Chinese herbal medicine named Bruceae Fructus, possessed potent cytotoxic effect against different pancreatic adenocarcinoma cell lines. Its anti-pancreatic cancer effect was comparable to that of the first-line chemotherapeutic agents such as gemcitabine and 5-fluorouracil, with a more favorable safety profile...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28547740/biliary-duodenal-anastomosis-using-magnetic-compression-following-massive-resection-of-small-intestine-due-to-strangulated-ileus-after-living-donor-liver-transplantation-a-case-report
#3
Ryusuke Saito, Hiroyuki Tahara, Seiichi Shimizu, Masahiro Ohira, Kentaro Ide, Kohei Ishiyama, Tsuyoshi Kobayashi, Hideki Ohdan
BACKGROUND: Despite the improvements of surgical techniques and postoperative management of patients with liver transplantation, biliary complications are one of the most common and important adverse events. We present a first case of choledochoduodenostomy using magnetic compression following a massive resection of the small intestine due to strangulated ileus after living donor liver transplantation. CASE PRESENTATION: The 54-year-old female patient had end-stage liver disease, secondary to liver cirrhosis, due to primary sclerosing cholangitis with ulcerative colitis...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28545522/brd4-inhibition-suppresses-cell-growth-migration-and-invasion-of-salivary-adenoid-cystic-carcinoma
#4
Limei Wang, Xiuyin Wu, Ruolin Wang, Chengzhe Yang, Zhi Li, Cunwei Wang, Fenghe Zhang, Pishan Yang
BACKGROUND: Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). METHODS: The human normal epithelial cells and SACC cells (ACC-LM and ACC-83) were treated with JQ1 at concentrations of 0, 0.1, 0.5 or 1 μM. Cell Counting Kit-8 (CCK-8) assay was performed to evaluate cell proliferation...
May 25, 2017: Biological Research
https://www.readbyqxmd.com/read/28544627/epithelial-to-mesenchymal-transition-transcription-factors-in-cancer-associated-fibroblasts
#5
REVIEW
Josep Baulida
Beyond inducing epithelial-to-mesenchymal transcription (EMT), transcriptional factors of the Snail, ZEB and Twist families (EMT-TFs) control global plasticity programs affecting cell stemness and fate. Literature addressing the reactivation of these factors in adult tumour cells is very extensive, as they enable cancer cell plasticity and fuel both tumour initiation and metastatic spread. Incipient data reveal that EMT-TFs are also expressed in fibroblasts, providing these with additional properties. Here, I will review recent reports on the expression of EMT-TFs in cancer-associated fibroblasts (CAFs)...
May 24, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28544624/pyrimidine-containing-epidermal-growth-factor-receptor-kinase-inhibitors-synthesis-and-biological-evaluation
#6
Gaurav Joshi, Himanshu Nayyar, Sourav Kalra, Praveen Sharma, Anjana Munshi, Sandeep Singh, Raj Kumar
Structure based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a-d are reported. The compounds (1a-d) inhibited the EGFR kinase activity in vitro with IC50 range 740 nM to 3 μM. mRNA expression of EGFR downstream target genes i.e. twist, c-fos and aurora were found to be altered upon treatment with compounds 1a-d. The compounds 1a-d exhibited excellent anticancer activity at low micromolar level (3.2-9 μM) in lung, colon and breast cancer cell lines...
May 23, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28544454/flexible-nanowire-cluster-as-a-wearable-colorimetric-humidity-sensor
#7
Zhiqiang Wei, Zhang-Kai Zhou, Qiuyu Li, Jiancai Xue, Andrea Di Falco, Zhongjian Yang, Jianhua Zhou, Xuehua Wang
Wearable plasmonic devices combine the advantages of high flexibility, ultrathinness, light weight, and excellent integration with the optical benefits mediated by plasmon-enhanced electric fields. However, two obstacles severely hinder further developments and applications of a wearable plasmonic device. One is the lack of efficient approach to obtaining devices with robust antimotion-interference property, i.e., the devices can work independently on the morphology changes of their working structures caused by arbitrary wearing conditions...
May 22, 2017: Small
https://www.readbyqxmd.com/read/28544063/ag-films-with-hierarchical-chiralities
#8
Shunai Che, Liguo Ma, Yuanyuan Cao, Yingying Duan, Lu Han
Preparing chiral metallic films is one of the primary challenges in materials science. Although physical fabrication methods for metal films with singular and large-sized chirality exist, chemical preparation of that with multi-structured chirality from atomic to larger scales have not been reported yet. Here, we report the chiral molecule-induced formation of chiral Ag films on a copper substrate through a redox reaction. Three levels of chirality were identified, primary twisted 'nanoflakes' with atomic crystal lattices, secondary helical stacking of these nanoflakes to form 'nanoplates' and tertiary micrometre-sized 'circinate' consisting of chiral arranged nanoplates...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28542355/hexahedral-mesh-generation-via-constrained-quadrilateralization
#9
Feifei Shang, Yangke Gan, Yufei Guo
Decomposing a volume into high-quality hexahedral cells is a challenging task in finite element simulations and computer graphics. Inspired by the use of a spatial twist continuum and frame field in previous hexahedral mesh generation methods, we present a method of hexahedral mesh generation via constrained quadrilateralization that combines a spatial twist continuum and frame fields. Given a volume represented by a tetrahedral mesh, surface quadrilateral mesh and frame field, we first extend the loop of the surface of a solid to a layer of hexahedral elements, then divide the solid into two smaller sub-solids by the layer, and finally handle them recursively until all of the sub-solids are empty...
2017: PloS One
https://www.readbyqxmd.com/read/28539961/yiqi-huayu-jiedu-decoction-inhibits-the-invasion-and-metastasis-of-gastric-cancer-cells-through-tgf-%C3%AE-smad-pathway
#10
Ting-Ting Wu, Jun Lu, Pei-Qiu Zheng, Shen-Lin Liu, Jian Wu, Wei Sun, Qing-Min Sun, Nai-Xia Ma, Xue-Lian Ding, Min Chen, Xi Zou
Background. Yiqi Huayu Jiedu Decoction (YHJD) can obviously improve the quality of life of those patients with gastric cancer and prolong their survival. Methods. In vitro experiments, we observe YHJD's effect on the cells' proliferation by MTT assay. Cell adhesion assay, wound-healing assay, and Transwell invasion assay serve to detect its influence on cells' adhesion, migration, and invasion, respectively. Inhibitor (10 μM/L of SB431542) and activator (10 ng/mL of TGF-β) of TGF-β/Smad pathway were used to estimate whether YHJD's impact on the biological behavior of gastric cancer cells was related to TGF-β/Smad pathway...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28539959/tardive-dystonia-related-with-aripiprazole
#11
Sunghwan Kim, Seung-Yup Lee, MinSeob Kim, Kyoung-Uk Lee
Tardive dystonia is characterized by sustained, generally slow involuntary twisting movements. It is estimated to occur at a frequency of 1% to 4% among patients who are taking an antipsychotic agent. Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. For aripiprazole, only a few cases have been reported for tardive dystonia. We present a young male, who developed a severe tardive dystonia after taking aripiprazole for 5 years...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28538155/structure-and-intermolecular-interactions-between-l-type-straight-flagellar-filaments
#12
Daniel Louzon, Avi Ginsburg, Walter Schwenger, Tom Dvir, Zvonimir Dogic, Uri Raviv
Bacterial mobility is powered by rotation of helical flagellar filaments driven by rotary motors. Flagellin isolated from the Salmonella Typhimurium SJW1660 strain, which differs by a point mutation from the wild-type strain, assembles into straight filaments in which flagellin monomers are arranged in a left-handed helix. Using small-angle x-ray scattering and osmotic stress methods, we investigated the structure of SJW1660 flagellar filaments as well as the intermolecular forces that govern their assembly into dense hexagonal bundles...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28537375/flexible-and-wearable-fiber-micro-supercapacitors-based-on-carbon-nanotube-agarose-gel-composite-electrodes
#13
Sung Kon Kim, Hyung-Jun Koo, Jinyun Liu, Paul V Braun
Fiber electrodes provide interesting opportunities for energy storage by providing both mechanical flexibility and the opportunity to impart multifunctionality to fabrics. We show here carbon nanotube (CNTs)-embedded agarose gel composite fiber electrodes with a diameter of ~120 μm consisting of 60 wt% CNTs that can serve as the basis for flexible and wearable fiber micro-supercapacitors (mSCs). Via an extrusion process, CNT bundles are induced to align in an agarose filament matrix. Due to the shear alignment of the CNT bundles, the dehydrated filaments have an electrical conductivity as high as 8...
May 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28536729/clinics-in-diagnostic-imaging-177-medical-meniscus-bucket-handle-tear-with-medial-oblique-meniscomeniscal-ligament
#14
Poh Lye Paul See
A 29-year-old man with a previous football injury to his left knee presented with pain of the same knee. The patient twisted it as he was turning a corner quickly while going up the stairs, leading to internal rotation of his femur on his tibia with his knee in flexion. MR imaging revealed a bucket-handle tear of the medial meniscus, as well as a complete tear of the anterior cruciate ligament. However, image interpretation was complicated by the presence of a medial oblique meniscomeniscal ligament, a rare normal variant among intermeniscal ligaments of the knee...
May 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28534391/understanding-electron-transport-in-disk-shaped-triphenylene-tris-naphthaleneimidazole-s-through-structural-modification-and-theoretical-investigation
#15
Yue Zhang, David A Hanifi, M Paz Fernandez-Liencres, Liana M Klivansky, Biwu Ma, Amparo Navarro, Yi Liu
Disk-shaped molecules with large aromatic π-surface are a class of organic semiconductors of which the charge carrier transport properties could be greatly facilitated by preferred intermolecular stacking of the π-surfaces. The optical and electronic properties are not only determined by the core aromatic structure of these disk-shaped molecules, but also strongly dependent on the sidechains, which directly impact the molecular self-assembly behavior in condensed phases. Triphenylene-tris(naphthaleneimidazole) (TP-TNI) is a recently reported n-type semiconductor featuring a large π-core and branched sidechains with an electron transporting mobility reaching 10-4 cm2V-1s-1...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533975/an-exhaustive-survey-of-regular-peptide-conformations-using-a-new-metric-for-backbone-handedness-h
#16
Ranjan V Mannige
The Ramachandran plot is important to structural biology as it describes a peptide backbone in the context of its dominant degrees of freedom-the backbone dihedral angles φ and ψ (Ramachandran, Ramakrishnan & Sasisekharan, 1963). Since its introduction, the Ramachandran plot has been a crucial tool to characterize protein backbone features. However, the conformation or twist of a backbone as a function of φ and ψ has not been completely described for both cis and trans backbones. Additionally, little intuitive understanding is available about a peptide's conformation simply from knowing the φ and ψ values of a peptide (e...
2017: PeerJ
https://www.readbyqxmd.com/read/28530665/molecular-engineering-of-chiral-colloidal-liquid-crystals-using-dna-origami
#17
Mahsa Siavashpouri, Christian H Wachauf, Mark J Zakhary, Florian Praetorius, Hendrik Dietz, Zvonimir Dogic
Establishing precise control over the shape and the interactions of the microscopic building blocks is essential for design of macroscopic soft materials with novel structural, optical and mechanical properties. Here, we demonstrate robust assembly of DNA origami filaments into cholesteric liquid crystals, one-dimensional supramolecular twisted ribbons and two-dimensional colloidal membranes. The exquisite control afforded by the DNA origami technology establishes a quantitative relationship between the microscopic filament structure and the macroscopic cholesteric pitch...
May 22, 2017: Nature Materials
https://www.readbyqxmd.com/read/28529789/3-hy-droxy-2-phenyl-2-3-3a-7a-tetra-hydro-1h-5h-pyrano-3-2-b-pyrrol-5-one-crystal-structure-and-hirshfeld-surface-analysis
#18
Julio Zukerman-Schpector, Angélica V Moro, Marcelo R Dos Santos, Carlos Roque D Correia, Mukesh M Jotani, Edward R T Tiekink
The title isoaltholactone derivative, C13H13NO3, has an NH group in place of the ether-O atom in the five-membered ring of the natural product. The five-membered ring is twisted about the N-C bond linking it to the six-membered ring, which has a half-chair conformation with the O atom connected to the ether-O atom lying above the plane defined by the remaining atoms. The dihedral angle between the mean planes of the rings comprising the fused-ring system is 75.10 (8)°. In the crystal, hy-droxy-O-H⋯N(amine) hydrogen bonding sustains linear supra-molecular chains along the a axis...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28529787/crystal-structure-of-2-chloro-1-3-bis-2-6-diiso-propyl-phen-yl-1-3-2-di-aza-phospho-lidine-2-oxide
#19
Alex J Veinot, Arthur D Hendsbee, Jason D Masuda
The title compound, C26H38ClN2OP, was synthesized by reacting phosphoryl chloride with N,N'-bis-(2,6-diiso-propyl-phen-yl)ethane-1,2-di-amine in the presence of N-methyl-morpholine which acted as an auxilliary base to quench the HCl released as a by-product. The resultant N-heterocyclic phosphine five-membered ring adopts a half-chair conformation and features a tetra-coordinate P atom ligated by the chelating di-amine [P-N = 1.6348 (14) and 1.6192 (14) Å], one double-bonded O atom [P1-O1 = 1.4652 (12) Å] and one Cl atom [P1-Cl1 = 2...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28529781/crystal-structure-of-catena-poly-di-aqua-bis-2-4-6-tri-methyl-benzoato-%C3%AE%C2%BAo-cobalt-ii-%C3%AE-aqua-%C3%AE%C2%BA-2-o-o-dihydrate
#20
Tuncer Hökelek, Nurcan Akduran, Safiye Özkaya, Hacali Necefoğlu
The asymmetric unit of the title one-dimensional polymeric compound, {[Co(C10H11O2)2(H2O)3]·2H2O} n , contains one Co(II) cation situated on a centre of inversion, one-half of a coordinating water mol-ecule, one 2,4,6-tri-methyl-benzoate (TMB) anion together with one coordinating and one non-coordinating water mol-ecule; the TMB anion acts as a monodentate ligand. In the anion, the carboxyl-ate group is twisted away from the attached benzene ring by 84.9 (2)°. The Co(II) atom is coordinated by two TMB anions and two water mol-ecules in the basal plane, while another water mol-ecule bridges the Co(II) atoms in the axial directions, forming polymeric chains running along [001]...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
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