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Yanbin Ma, Haofeng Zhang, Chaoliang Xiong, Zheng Liu, Qingji Xu, Jing Feng, Jun Zhang, Zhaoqing Wang, Xiyun Yan
Cadherin switch is an initiating factor of epithelial-mesenchymal transition (EMT) and is intimately correlated with cancer metastatic potential; however, its underlying mechanisms remain unclear. Here, using a transforming growth factor-β (TGF-β)-induced EMT model, we provide explicit evidence that CD146, with elevated expression and activity in a variety of cancers, is a key factor involved in the cadherin switch. We show that CD146 can be induced by TGF-β signaling. Moreover, CD146 expression is positively correlated with the activation levels of STAT3/Twist and ERK pathways...
May 16, 2018: Cancer Letters
Maxim V Pyatnov, Stepan Ya Vetrov, Ivan V Timofeev
Coupling between the defect mode of a cholesteric liquid crystal and the localized mode of a cholesteric liquid crystal-phase plate-metal structure is theoretically demonstrated. It is shown that the transmittance spectrum can be tuned by changing the twist-defect angle and helix pitch, which are governed by external factors. The spectra for different circular polarizations of the incident light are different; specifically, at the nondiffracting polarization, there is no defect-mode transmittance peak.
March 2018: Physical Review. E
Amalia Maria Paschou, Maria Katsikini, Dimitrios Christofilos, John Arvanitidis, Sotirios Ves
The high pressure response of type-I collagen from bovine Achilles tendon is investigated with micro-Raman spectroscopy. Fluorinert™ and methanol-ethanol mixtures were used as pressure transmitting media (PTM) in a diamond anvil cell. The Raman spectrum of collagen is dominated by three bands centred at approximately 1450, 1660 and 2930 cm-1 , attributed to C-H deformation, C=O stretching of the peptide bond (amide-I band) and C-H stretching modes, respectively. Upon pressure increase, using Fluorinert™ as PTM, a shift towards higher frequencies of the C-H stretching and deformation peaks is observed...
May 18, 2018: FEBS Journal
Xiaoxu Zhou, Chongxiang Xiong, Evelyn Tolbert, Ting C Zhao, George Bayliss, Shougang Zhuang
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial-mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 were highly expressed in mouse kidney with unilateral ureteral obstruction and cultured mouse kidney proximal tubular (TKPT) cells undergoing EMT. Inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) attenuated renal fibrosis, which was associated with preserving E-cadherin expression and inhibiting Vimentin up-regulation in the obstructed kidney...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sebile Işık Büyükekşi, Ahmet Karatay, Nursel Acar, Betül Küçüköz, Ayhan Elmali, Abdurrahman Şengül
Perylene diimides (PDIs) are among the most versatile and functional dyes for supramolecular structures displaying characteristic high absorptions and photo-luminescence properties as the prerequisite for optoelectronic thin film devices. Despite intense investigations into these semi-conducting and electro-active materials, details of their electronic structure are still under examination. In particular, non-planar twisted PDIs as an electron acceptor is a promising model system for efficient charge generation and transport processes...
May 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P Zhou, Jian Shi, Tiebang Kang
Rationale: Twist is a key transcription factor for induction of epithelial-mesenchymal transition (EMT), which promotes cell migration, invasion, and cancer metastasis, confers cancer cells with stem cell-like characteristics, and provides therapeutic resistance. However, the functional roles and targeted genes of Twist in EMT and cancer progression remain elusive. Methods: The potential targeted genes of Twist were identified from the global transcriptomes of T47D/Twist cells by microarray analysis. EMT phenotype was detected by western blotting and immunofluorescence of marker proteins...
2018: Theranostics
Nathan A Carter, Tijana Z Grove
Generation of electric potential upon external stimulus has attracted much attention for the development of highly functional sensors and devices. Herein, we report large-displacement, fast actuation in the self-assembled engineered repeat protein Consensus Tetratricopeptide Repeat protein (CTPR18) materials. The ionic nature of the CTPR18 protein coupled to the long-range alignment upon self-assembly results in the measured conductivity of 7.1 × 10-2 S cm-1, one of the highest reported for protein materials...
May 17, 2018: Journal of the American Chemical Society
Amin Rahpeyma, Saeedeh Khajehahmadi
Circumpalatal wiring has 2 negative points. The first is premature loosening of the wire and the second is tongue irritation caused by exposed wire in roof of the mouth. In this article, a modified technique (palatal wiring) is introduced in which these 2 problems are targeted. In this technique, a small bur hole is created into the hard palate, without the need for flap reflection and wire is passed through it, grasps in the nose, and returns to the oral cavity via sublabial puncture point then 2 ends are twisted in labial vestibule...
May 15, 2018: Journal of Craniofacial Surgery
Carsten Schmuck, Xiao-Yu Hu, Martin Ehlers, Elio Zellermann, Stefanie Mosel, Hao Jiang, Jan-Erik Ostwaldt, Shirley Knauer, Leyong Wang, Tingting Wang
Small peptides capable of assembling into well-defined nanostructures have attracted extensive attention due to their interesting applications as biomaterials. Herein, we report the first example of a pillararene functionalized with a guanidiniocarbonyl pyrrole (GCP)-conjugated short peptide segment. The obtained amphiphilic peptide 1 spontaneously self-assembles into a supramolecular β-sheet in aqueous solution based on host-guest interaction between pillararene and GCP unit as well as hydrogen-bonding between the peptide strands...
May 17, 2018: Chemistry: a European Journal
James R Usherwood, Benjamin J H Smith
Many medium and large herbivores locomote forwards very slowly and intermittently when grazing. While the footfall order during grazing is the same as for walking, the relative fore-hind timing-phasing-is quite different. Extended periods of static stability are clearly required during grazing; however, stability requirements are insufficient to account for the timing. Aspects of relatively rapid rolling and pitching-toppling due to the resistance of the back to bending and twisting-can be included in a simplifying geometric model to explain the observation that, in grazing livestock, a step forward with a forefoot is consistently and immediately followed by a step forward from the hind; but not vice versa...
May 2018: Biology Letters
Van-Chien Bui, Thi-Huong Nguyen
Cations-induced DNA aggregation can modify the local structure of oligonucleotides and has potential applications in medicine and biotechnology. Here, we used atomic force microscopy to investigate λ-DNA aggregation on Mg2+ -treated glass (Mg2+ /glass) and in Mg2+ solution. Atomic force microscopy topography images showed that some DNA fragments were slightly stacked together on 10 mM Mg2+ /glass and stacked stronger on ≥50 mM Mg2+ /glass. They also showed that DNA aggregated stronger in Mg2+ solution than on Mg2+ /glass, ie, DNAs are strongly stacked and twisted at 10 mM Mg2+ , rolled together at 50 mM Mg2+ , and slightly aggregated to form small particles at 100 mM Mg2+ ...
May 15, 2018: Journal of Molecular Recognition: JMR
U Segal, H Bar, J Shani
OBJECTIVES: To describe a surgical technique using bilateral twisted string-of-pearls locking plates for lumbosacral fracture-luxation in dogs and cats. MATERIALS AND METHODS: Twisted string-of-pearls locking plates were used to stabilise lumbosacral fracture-luxation between 2013 and 2017. Decompression of the cauda equina was achieved by dorsal laminectomy through a dorso-medial approach. Stabilisation was achieved using bilateral string-of-pearls plates attached to the lateral aspects of the vertebral body cranial to the fractured vertebra and the iliosacral joints...
May 15, 2018: Journal of Small Animal Practice
Serkan Fazlı Çelik, Cemşit Karakurt, Yılmaz Tabel, Taner Elmas, Saim Yoloğlu
BACKGROUND: There is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. METHODS: Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography...
May 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Łukasz Kielesiński, Daniel T Gryko, Andrzej L Sobolewski, Olaf W Morawski
The fluorescence intensity of bis-coumarins linked via CONH and COO functionalities are shown to exhibit a strong dependance on solvent polarity. The presence of the intramolecular hydrogen bond between the C[double bond, length as m-dash]O oxygen atom of coumarin and amide-NH moieties reduces the number of thermodynamically populated conformations in both ground and electronically excited states and an anti-arrangement of coumarin units is favored. Additionally, the rigidity of the linker raises the barrier to the conical intersection with the ground state, and in non-polar solvents strong fluorescence is observed...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
Anamarija Knežević, Irena Dokli, Marin Sapunar, Suzana Šegota, Ute Baumeister, Andreja Lesac
The investigation of liquid crystal (LC) mixtures is of great interest in tailoring material properties for specific applications. The recent discovery of the twist-bend nematic phase (NTB ) has sparked great interest in the scientific community, not only from a fundamental viewpoint, but also due to its potential for innovative applications. Here we report on the unexpected phase behaviour of a binary mixture of twist-bend nematogens. A binary phase diagram for mixtures of imino-linked cyanobiphenyl (CBI) dimer and imino-linked benzoyloxy-benzylidene (BB) dimer shows two distinct domains...
2018: Beilstein Journal of Nanotechnology
Takeshi Oishi, Makoto Yoritate, Takaaki Sato, Noritaka Chida
The title compound, C17 H23 NO4 ·H2 O, is an epimer of the natural tetra-cyclic alkaloid isosaxorumamide which consists of a fused 5-7-5 tricyclic core and a di-hydro-furan-one substituent. The terminal di-hydro-furan ring is essentially planar with a maximum deviation of 0.0273 (14) Å from the mean plane and oxolane, azepane and pyrrolidine rings in the tricyclic ring system adopt twist, twist-chair and envelope forms, respectively. In the crystal, the amide and water mol-ecules are linked by O-H⋯O hydrogen bonds, forming a tape structure running along the b- axis direction...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Young-Inn Kim, Seong-Jae Yun, Sung Kwon Kang
The title compound, C26 H20 N2 , was obtained during a search for new π-extended ligands with the potential to generate efficient phosphors with iridium(III) for organic light-emitting devices (OLEDs). The benzoquinoxaline ring system is almost planar (r.m.s. deviation = 0.076 Å). A pseudo-twofold rotation axis runs through the midpoints of the C2-C3 and C9-C10 bonds. The two phenyl rings are twisted relative to the benzoquinoxaline ring system, making dihedral angles of 53.91 (4) and 36.86 (6)°. In the crystal, C-H⋯π (arene) inter-actions link the mol-ecules, but no π-π inter-actions between aromatic rings are observed...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Dian Alwani Zainuri, Ibrahim Abdul Razak, Suhana Arshad
The title compound, C31 H20 O, was synthesized using a Claisen-Schmidt condensation. The enone group adopts an s - trans conformation and the anthracene ring systems are twisted at angles of 85.21 (19) and 83.98 (19)° from the enone plane. In the crystal, mol-ecules are connected into chains along [100] via weak C-H⋯π inter-actions. The observed band gap of 3.03 eV is in excellent agreement with that (3.07 eV) calculated using density functional theory (DFT) at the B3LYP/6-311++G(d,p) level. The Hirshfeld surface analysis indicates a high percentage of C⋯H/H⋯C (41...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Maria Makarova, Alexey A Tsygankov, Olga Chusova, Ivan V Linko, Pavel V Dorovatovskii, Yan V Zubavichus
The title compound, [RuCl2 (C10 H14 )(C26 H35 O2 P)] ( I ), crystallizes in the monoclinic space group P 21 / c with two crystallographically independent mol-ecules ( A and B ) in the asymmetric unit. The geometries of both mol-ecules are very similar and distinguished only by the twist angles of the two benzene rings in the phosphine substituents [89.54 (14) and 78.36 (14)° for mol-ecules A and B , respectively]. The Ru atoms have classical pseudo-tetra-hedral piano-stool coordination environments. The conformation of each mol-ecule is stabilized by intra-molecular C-H⋯O and C-H⋯Cl hydrogen bonds and C-H⋯π inter-actions...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Patrick O'Brien, Matthias Zeller, Wei-Tsung Lee
The title compound, [NiBr(C25 H29 N2 O)], contains an NiII atom with a slightly distorted square-planar coordination environment defined by one O and two N atoms from the 2-{[(8-aminona-phthalen-1-yl)imino]-meth-yl}-4,6-di- tert -butyl-phenolate ligand and a bromide anion. The Ni-O and Ni-N bond lengths are slightly longer than those observed in the phenyl backbone counterpart, which can be attributed to the larger steric hindrance of the naphthyl group in the structure of the title compound. The mol-ecule as a whole is substanti-ally distorted, with both the planar naphthalene-1,8-di-amine and imino-meth-yl-phenolate substitutents rotated against the NiN2 OBr plane by 38...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
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