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Slow wave sleep

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https://www.readbyqxmd.com/read/28939975/ketamine-induced-glutamatergic-mechanisms-of-sleep-and-wakefulness-insights-for-developing-novel-treatments-for-disturbed-sleep-and-mood
#1
Wallace C Duncan, Elizabeth D Ballard, Carlos A Zarate
Ketamine, a drug with rapid antidepressant effects and well-described effects on slow wave sleep (SWS), is a useful intervention for investigating sleep-wake mechanisms involved in novel therapeutics. The drug rapidly (within minutes to hours) reduces depressive symptoms in individuals with major depressive disorder (MDD) or bipolar disorder (BD), including those with treatment-resistant depression. Ketamine treatment elevates extracellular glutamate in the prefrontal cortex. Glutamate, in turn, plays a critical role as a proximal element in a ketamine-initiated molecular cascade that increases synaptic strength and plasticity, which ultimately results in rapidly improved mood...
September 23, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28939929/stimulus-induced-transitions-between-spike-wave-discharges-and-spindles-with-the-modulation-of-thalamic-reticular-nucleus
#2
Denggui Fan, Qingyun Wang, Jianzhong Su, Hongguang Xi
It is believed that thalamic reticular nucleus (TRN) controls spindles and spike-wave discharges (SWD) in seizure or sleeping processes. The dynamical mechanisms of spatiotemporal evolutions between these two types of activity, however, are not well understood. In light of this, we first use a single-compartment thalamocortical neural field model to investigate the effects of TRN on occurrence of SWD and its transition. Results show that the increasing inhibition from TRN to specific relay nuclei (SRN) can lead to the transition of system from SWD to slow-wave oscillation...
September 22, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28939859/cortical-up-states-induce-the-selective-weakening-of-subthreshold-synaptic-inputs
#3
Julian Bartram, Martin C Kahn, Simon Tuohy, Ole Paulsen, Tony Wilson, Edward O Mann
Slow-wave sleep is thought to be important for retuning cortical synapses, but the cellular mechanisms remain unresolved. During slow-wave activity, cortical neurons display synchronized transitions between depolarized Up states and hyperpolarized Down states. Here, using recordings from LIII pyramidal neurons from acute slices of mouse medial entorhinal cortex, we find that subthreshold inputs arriving during the Up state undergo synaptic weakening. This does not reflect a process of global synaptic downscaling, as it is dependent on presynaptic spiking, with network state encoded in the synaptically evoked spine Ca(2+) responses...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28934530/intraindividual-increase-of-homeostatic-sleep-pressure-across-acute-and-chronic-sleep-loss-a-high-density-eeg-study
#4
Angelina Maric, Caroline Lustenberger, Esther Werth, Christian R Baumann, Rositsa Poryazova, Reto Huber
Study Objectives: To compare intraindividually the effects of acute sleep deprivation (ASD) and chronic sleep restriction (CSR) on the homeostatic increase in slow wave activity (SWA) and to relate it to impairments in basic cognitive functioning, that is, vigilance. Methods: The increase in SWA after ASD (40 hours of wakefulness) and after CSR (seven nights with time in bed restricted to 5 hours per night) relative to baseline sleep was assessed in nine healthy, male participants (age = 18-26 years) by high-density electroencephalography...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934526/mechanisms-of-memory-retrieval-in-slow-wave-sleep
#5
Scott A Cairney, Justyna M Sobczak, Shane Lindsay, M Gareth Gaskell
Study Objectives: Memories are strengthened during sleep. The benefits of sleep for memory can be enhanced by re-exposing the sleeping brain to auditory cues; a technique known as targeted memory reactivation (TMR). Prior studies have not assessed the nature of the retrieval mechanisms underpinning TMR: the matching process between auditory stimuli encountered during sleep and previously encoded memories. We carried out two experiments to address this issue. Methods: In Experiment 1, participants associated words with verbal and nonverbal auditory stimuli before an overnight interval in which subsets of these stimuli were replayed in slow-wave sleep...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28932187/linking-network-activity-to-synaptic-plasticity-during-sleep-hypotheses-and-recent-data
#6
REVIEW
Carlos Puentes-Mestril, Sara J Aton
Research findings over the past two decades have supported a link between sleep states and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain this relationship. For example, multiple studies have shown structural alterations to synapses (including changes in synaptic volume, spine density, and receptor composition) indicative of synaptic weakening after a period of sleep. Direct measures of neuronal activity and synaptic strength support the idea that a period of sleep can reduce synaptic strength...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28922194/benign-neonatal-sleep-myoclonus-evokes-somatosensory-responses
#7
Emma Losito, Monika Eisermann, Patricia Vignolo, Shushanik Hovhannisyan, Jean François Magny, Anna Kaminska
PURPOSE: Benign neonatal sleep myoclonus is a common nonepileptic condition occurring in neurologically normal full-term newborns. During jerks, EEG has always been described as normal. The aim of this study was to describe EEG changes associated with the myoclonic jerks. METHODS: Polygraphic video-EEG recordings of four full-term neonates presenting benign neonatal sleep myoclonus were studied. Myoclonic jerks were analyzed regarding their topography, frequency, propagation pattern, and reflex component...
September 14, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28921856/disruption-of-perineuronal-nets-increases-the-frequency-of-sharp-wave-ripple-events
#8
ZhiYong Sun, P Lorenzo Bozzelli, Adam Caccavano, Megan Allen, Jason Balmuth, Stefano Vicini, Jian-Young Wu, Katherine Conant
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems level memory consolidation. SWRs are initiated by CA2 or CA3 pyramidal cells and require initial excitation of CA1 pyramidal cells as well as participation of parvalbumin (PV) expressing fast spiking (FS) inhibitory interneurons...
September 16, 2017: Hippocampus
https://www.readbyqxmd.com/read/28921043/slow-wave-activity-and-executive-dysfunction-in-children-with-sleep-disordered-breathing
#9
Jessica A Christiansz, Chloe R Lappin, Aidan J Weichard, Gillian M Nixon, Margot J Davey, Rosemary S C Horne, Sarah N Biggs
PURPOSE: This study aimed to examine slow wave activity (SWA), a marker of homeostatic regulation, as a potential mechanism linking sleep disordered breathing (SDB) with executive dysfunction in children. METHODS: Executive function domains of working memory, spatial planning, information processing, and sustained attention were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in children (N = 40; 5-12 years) referred for clinical diagnosis of SDB...
September 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28913599/the-mediating-role-of-cortical-thickness-and-gray-matter-volume-on-sleep-slow-wave-activity-during-adolescence
#10
Aimée Goldstone, Adrian R Willoughby, Massimiliano de Zambotti, Peter L Franzen, Dongjin Kwon, Kilian M Pohl, Adolf Pfefferbaum, Edith V Sullivan, Eva M Müller-Oehring, Devin E Prouty, Brant P Hasler, Duncan B Clark, Ian M Colrain, Fiona C Baker
During the course of adolescence, reductions occur in cortical thickness and gray matter (GM) volume, along with a 65% reduction in slow-wave (delta) activity during sleep (SWA) but empirical data linking these structural brain and functional sleep differences, is lacking. Here, we investigated specifically whether age-related differences in cortical thickness and GM volume and cortical thickness accounted for the typical age-related difference in slow-wave (delta) activity (SWA) during sleep. 132 healthy participants (age 12-21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study were included in this cross-sectional analysis of baseline polysomnographic, electroencephalographic, and magnetic resonance imaging data...
September 14, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28910914/-changes-to-sleep-patterns-in-young-migrants-at-high-altitude
#11
Z D Ha, K L Pan, X L Jian, J P Luo, S Q Guan, W W Guo
Objective: To explore the relationship between the level of acclimatization and the changes to sleep architecture in migrants at high altitude. Methods: Nocturnal sleep recordings of 50 subjects aged between 18 and 25 years [mean age (20.9±2.0) years] were analyzed. Those young volunteers were divided into 3 700 m-3 m group(n=10, migrated to an altitude of 3 700 metres for 3 months), 3 700 m-1 y group(n=10, for 1 year) , 5 380 m-3 m group(n=8), 5 380 m-1 y group(n=9), and compared with a control group(n=13, at 1 400 m altitude)...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28899014/slow-wave-sleep-disruption-increases-cerebrospinal-fluid-amyloid-%C3%AE-levels
#12
Yo-El S Ju, Sharon J Ooms, Courtney Sutphen, Shannon L Macauley, Margaret A Zangrilli, Gina Jerome, Anne M Fagan, Emmanuel Mignot, John M Zempel, Jurgen A H R Claassen, David M Holtzman
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer's disease pathologies including tauopathy or inflammation. To date, studies have not examined which aspect of sleep modulates amyloid-β or other Alzheimer's disease biomarkers. Seventeen healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-β, tau, total protein, YKL-40, and hypocretin...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28882722/cognition-in-patients-with-benign-epilepsy-with-centrotemporal-spikes-a-study-with-long-term-veeg-and-rs-fmri
#13
Xinxin Yan, Qing Yu, Yuting Gao, Liting Li, Danhua Yu, Ying Chen, Xiaojuan Yao, Weidong Yang, Zhijuan Chen, Jianzhong Yin, Yang An, Ke Tan
OBJECTIVE: The purpose of this study was to investigate the relationship between alterations of functional brain network and cognition in patients with benign epilepsy with centrotemporal spikes (BECTS) as a function of spike-wave index (SWI) during slow wave sleep. METHODS: Resting-state functional magnetic resonance imaging (RS-fMRI) data and Intelligence Quotient (IQ) were collected from two groups of patients with BECTS, including a SWI<50% group (5 cases) and a SWI≥50% group (7 cases)...
September 4, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28874450/hypothalamic-tuberomammillary-nucleus-neurons-electrophysiological-diversity-and-essential-role-in-arousal-stability
#14
Akie Fujita, Patricia Bonnavion, Miryam H Wilson, Laura E Mickelsen, Julien Bloit, Luis de Lecea, Alexander C Jackson
Histaminergic (HA) neurons, found in the posterior hypothalamic tuberomammillary nucleus (TMN), extend fibers throughout the brain and exert modulatory influence over numerous physiological systems. Multiple lines of evidence suggest that the activity of HA neurons is important in the regulation of vigilance despite the lack of direct, causal evidence demonstrating its requirement for the maintenance of arousal during wakefulness. Given the strong correlation between HA neuron excitability and behavioral arousal, we investigated both the electrophysiological diversity of HA neurons in brain slices and the effect of their acute silencing in vivo in male mice...
September 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28866052/sleep-inducing-effect-of-substance-p-cholera-toxin-a-subunit-in-mice
#15
Mark R Zielinski, Dmitry Gerashchenko
Evidence indicates that the neuropeptide substance P (SP) can act through neurokinin receptors to alter sleep and/or non-rapid eye movement (NREM) sleep slow-wave activity. Consequently, drugs acting on SP receptors could potentially be used as a novel treatment for sleep-related disorders. In the present study, we used SP conjugated with cholera toxin A subunit (SP-CTA), which enhances its duration of activity on SP receptor-expressing cells, to determine the effects of selectively activating SP receptor-expressing brain cells on sleep regulation in mice...
September 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28859716/non-rem-sleep-instability-in-children-with-primary-monosymptomatic-sleep-enuresis
#16
Leticia Azevedo Soster, Rosana Cardoso Alves, Simone Nascimento Fagundes, Adrienne Lebl, Eliana Garzon, Vera H Koch, Raffaele Ferri, Oliviero Bruni
STUDY OBJECTIVES: Sleep enuresis is one of the most common sleep disturbances in childhood. Parental perception of deeper sleep in children with sleep enuresis is not confirmed by objective studies. However, evidence of disturbed sleep has been demonstrated by questionnaire, actigraphy, and polysomnographic studies, but no neurophysiological correlation with low arousability has been found. The goal of this study was to analyze the sleep microstructure of children with sleep enuresis using cyclic alternating pattern (CAP) analysis...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28845310/developmental-changes-in-sleep-oscillations-during-early-childhood
#17
Eckehard Olbrich, Thomas Rusterholz, Monique K LeBourgeois, Peter Achermann
Although quantitative analysis of the sleep electroencephalogram (EEG) has uncovered important aspects of brain activity during sleep in adolescents and adults, similar findings from preschool-age children remain scarce. This study utilized our time-frequency method to examine sleep oscillations as characteristic features of human sleep EEG. Data were collected from a longitudinal sample of young children (n = 8; 3 males) at ages 2, 3, and 5 years. Following sleep stage scoring, we detected and characterized oscillatory events across age and examined how their features corresponded to spectral changes in the sleep EEG...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28845178/transdermal-nicotine-patch-effects-on-eeg-power-spectra-and-heart-rate-variability-during-sleep-of-healthy-male-adults
#18
Jong-Bae Choi, Yu-Jin G Lee, Do-Un Jeong
OBJECTIVE: The effect of transdermal nicotine patch on sleep physiology is not well established. The current study aimed to examine the influence of nicotine patch on homeostatic sleep propensity and autonomic nervous system. METHODS: We studied 16 non-smoking young healthy volunteers with nocturnal polysomnography in a double blind crossover design between sleep with and without nicotine patch. We compared the sleep variables, sleep EEG power spectra, and heart rate variability...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28843017/motor-hyperactivity-of-the-iron-deficient-rat-an-animal-model-of-restless-legs-syndrome
#19
Yuan-Yang Lai, Yu-Hsuan Cheng, Kung-Chiao Hsieh, Darian Nguyen, Keng-Tee Chew, Lalini Ramanathan, Jerome M Siegel
BACKGROUND: Abnormal striatal dopamine transmission has been hypothesized to cause restless legs syndrome. Dopaminergic drugs are commonly used to treat restless legs syndrome. However, they cause adverse effects with long-term use. An animal model would allow the systematic testing of potential therapeutic drugs. A high prevalence of restless legs syndrome has been reported in iron-deficient anemic patients. We hypothesized that the iron-deficient animal would exhibit signs similar to those in restless legs syndrome patients...
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28835407/sleep-architecture-and-the-risk-of-incident-dementia-in-the-community
#20
Matthew P Pase, Jayandra J Himali, Natalie A Grima, Alexa S Beiser, Claudia L Satizabal, Hugo J Aparicio, Robert J Thomas, Daniel J Gottlieb, Sandford H Auerbach, Sudha Seshadri
OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male)...
August 23, 2017: Neurology
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