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Slow wave sleep

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https://www.readbyqxmd.com/read/29130467/-a-comparative-study-of-three-systems-for-quantifying-the-spike-and-wave-index-in-patients-with-continuous-spikes-and-waves-during-slow-sleep
#1
G Azcona, I G Gurtubay, A Mosquera, B Ibanez, K Cambra, S Aguilera-Albesa, M E Yoldi-Petri
INTRODUCTION: Continuous spikes and waves during slow sleep (CSWS) is an epileptic encephalopathy of childhood with a pattern of epileptiform discharges during sleep, which, if prolonged over time, produce severe neuropsychological impairment. Quantification of the paroxysms by means of a spike and wave index (SWI) > 85% establishes a presumptive diagnosis and allows early therapy to be started to prevent such impairment. AIMS: To compare the results of the classic method for calculating the SWI against two proposals that optimise the relation between the analysis time employed and the diagnostic sensitivity...
November 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29121278/frontal-alpha-delta-eeg-does-not-preclude-volitional-response-during-anaesthesia-prospective-cohort-study-of-the-isolated-forearm-technique
#2
A L Gaskell, D F Hight, J Winders, G Tran, A Defresne, V Bonhomme, A Raz, J W Sleigh, R D Sanders
Background: The isolated forearm test (IFT) is the gold standard test of connected consciousness (awareness of the environment) during anaesthesia. The frontal alpha-delta EEG pattern (seen in slow wave sleep) is widely held to indicate anaesthetic-induced unconsciousness. A priori we proposed that one responder with the frontal alpha-delta EEG pattern would falsify this concept. Methods: Frontal EEG was recorded in a subset of patients from three centres participating in an international multicentre study of IFT responsiveness following tracheal intubation...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29119218/odor-cueing-during-slow-wave-sleep-benefits-memory-independently-of-low-cholinergic-tone
#3
Jens G Klinzing, Sabine Kugler, Surjo R Soekadar, Björn Rasch, Jan Born, Susanne Diekelmann
RATIONALE: Sleep-dependent memory consolidation depends on the concerted reactivation of memories in the hippocampo-neocortical system. The communication of reactivated information from the hippocampus to the neocortex is assumed to be enabled by low levels of acetylcholine, particularly during slow-wave sleep (SWS). Recent studies suggest that the reactivation of memories does not only occur spontaneously but can also be externally triggered by re-presenting learning-associated cues during sleep...
November 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29114733/sodium-oxybate-for-excessive-daytime-sleepiness-and-sleep-disturbance-in-parkinson-disease-a-randomized-clinical-trial
#4
Fabian Büchele, Marc Hackius, Sebastian R Schreglmann, Wolfgang Omlor, Esther Werth, Angelina Maric, Lukas L Imbach, Stefan Hägele-Link, Daniel Waldvogel, Christian R Baumann
Importance: Sleep-wake disorders are a common and debilitating nonmotor manifestation of Parkinson disease (PD), but treatment options are scarce. Objective: To determine whether nocturnal administration of sodium oxybate, a first-line treatment in narcolepsy, is effective and safe for excessive daytime sleepiness (EDS) and disturbed nighttime sleep in patients with PD. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, crossover phase 2a study carried out between January 9, 2015, and February 24, 2017...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29111358/are-there-sleep-promoting-neurons-in-the-mouse-parafacial-zone
#5
K Sakai
Although recent studies have reported that gamma-aminobutyric acid (GABA) neurons in the parafacial zone (PZ) of the rostral medulla are needed for the induction of slow-wave sleep (SWS) and that the PZ is a medullary SWS-promoting center, it remains unknown whether the PZ contains SWS-active or sleep-promoting neurons. In the present study, a total of 125 neurons were recorded, for the first time, in non-anesthetized, head-restrained mice during the complete wake-sleep cycle throughout the PZ of the rostral medulla...
October 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/29106402/selective-neuronal-lapses-precede-human-cognitive-lapses-following-sleep-deprivation
#6
Yuval Nir, Thomas Andrillon, Amit Marmelshtein, Nanthia Suthana, Chiara Cirelli, Giulio Tononi, Itzhak Fried
Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. Moreover, sleep deprivation brings about vehicle accidents and medical errors and is therefore an urgent topic of investigation. During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure, which results in slow behavioral performance (cognitive lapses) typically attributed to attentional thalamic and frontoparietal circuits, but the underlying mechanisms remain unclear...
November 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29101344/dynamic-coupling-between-slow-waves-and-sleep-spindles-during-slow-wave-sleep-in-humans-is-modulated-by-functional-pre-sleep-activation
#7
Juliana Yordanova, Roumen Kirov, Rolf Verleger, Vasil Kolev
Co-existent sleep spindles and slow waves have been viewed as a mechanism for offline information processing. Here we explored if the temporal synchronization between slow waves and spindle activity during slow wave sleep (SWS) in humans was modulated by preceding functional activations during pre-sleep learning. We activated differentially the left and right hemisphere before sleep by using a lateralized variant of serial response time task (SRTT) and verified these inter-hemispheric differences by analysing alpha and beta electroencephalographic (EEG) activities during learning...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29101338/in-human-non-rem-sleep-more-slow-wave-activity-leads-to-less-blood-flow-in-the-prefrontal-cortex
#8
Laura Tüshaus, Ximena Omlin, Ruth O'Gorman Tuura, Andrea Federspiel, Roger Luechinger, Philipp Staempfli, Thomas Koenig, Peter Achermann
Cerebral blood flow (CBF) is related to integrated neuronal activity of the brain whereas EEG provides a more direct measurement of transient neuronal activity. Therefore, we addressed what happens in the brain during sleep, combining CBF and EEG recordings. The dynamic relationship of CBF with slow-wave activity (SWA; EEG sleep intensity marker) corroborated vigilance state specific (i.e., wake, non-rapid eye movement (NREM) sleep stages N1-N3, wake after sleep) differences of CBF e.g. in the posterior cingulate, basal ganglia, and thalamus, indicating their role in sleep-wake regulation and/or sleep processes...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089440/hippocampal-prefrontal-reactivation-during-learning-is-stronger-in-awake-as-compared-to-sleep-states
#9
Wenbo Tang, Justin D Shin, Loren M Frank, Shantanu P Jadhav
Hippocampal sharp-wave ripple (SWR) events occur during both behavior (awake SWRs) and slow-wave sleep (sleep SWRs). Awake and sleep SWRs both contribute to spatial learning and memory, thought to be mediated by the coordinated reactivation of behavioral experiences in hippocampal-cortical circuits seen during SWRs. Current hypotheses suggest that reactivation contributes to memory consolidation processes, but whether awake and sleep reactivation are suited to play similar or different roles remains unclear...
October 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29080950/is-poor-sleep-associated-with-obesity-in-older-adults-a-narrative-review-of-the-literature
#10
Maria C Norton, Stefano Eleuteri, Silvia Cerolini, Andrea Ballesio, Salvatore C Conte, Paolo Falaschi, Fabio Lucidi
INTRODUCTION: To address the worldwide epidemic of obesity, a sizable literature implicates sleep problems in the onset of obesity in younger populations. However, less is known about how this process may operate among older adults, which is of concern, given demographic shifts that have resulted in a much higher proportion of developed nations around the world reaching late life. METHODS: We offer a current review of the literature studying older adults and examining associations between sleep quality and obesity in this population...
October 28, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29080930/dysfunction-of-gabaergic-neurons-in-the-parafacial-zone-mediates-sleep-disturbances-in-a-streptozotocin-induced-rat-model-of-sporadic-alzheimer-s-disease
#11
Jin-Zhi Song, Su-Ying Cui, Xiang-Yu Cui, Xiao Hu, Yu-Nu Ma, Hui Ding, Hui Ye, Yong-He Zhang
Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present study, we characterize the sleep/wake cycles and explore a potential mechanism underlying sleep disturbance in a rat model of sAD induced via intracerebroventricular (icv) injection of streptozotocin (STZ)...
October 28, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29079823/sex-differences-in-light-sensitivity-impact-on-brightness-perception-vigilant-attention-and-sleep-in-humans
#12
Sarah L Chellappa, Roland Steiner, Peter Oelhafen, Christian Cajochen
Artificial light endows a "round-the-clock", 24-h/7-d society. Chronic exposure to light at night contributes to health hazards for humans, including disorders of sleep. Yet the influence of inter-individual traits, such as sex-differences, on light sensitivity remains to be established. Here we investigated potential sex-differences to evening light exposure of 40 lx at 6500 K (blue-enriched) or at 2500 K (non-blue-enriched), and their impact on brightness perception, vigilant attention and sleep physiology...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29073254/combining-mad-and-cpap-as-an-effective-strategy-for-treating-patients-with-severe-sleep-apnea-intolerant-to-high-pressure-pap-and-unresponsive-to-mad
#13
Hsiang-Wen Liu, Yunn-Jy Chen, Yi-Chun Lai, Ching-Yi Huang, Ya-Ling Huang, Ming-Tzer Lin, Sung-Ying Han, Chi-Ling Chen, Chong-Jen Yu, Pei-Lin Lee
INTRODUCTION: This study aimed to determine the effect of combining positive airway pressure (PAP) therapy and mandibular advancement device (MAD) in patients with severe obstructive sleep apnea (OSA) who were pressure intolerant for PAP and were unresponsive to MAD. METHODS: This retrospective study reviewed the medical records of severe OSA patients with apnea-hypopnea index (AHI) ≥ 30/hr who were diagnosed between October 1, 2008 and June 30, 2014. Patients were initially treated with 2 weeks of PAP, and those who were intolerant to high-pressure PAP (≥15 cm H2O) were switched to 12 weeks of MAD, which is a monobloc designed at 75% of maximum protrusion...
2017: PloS One
https://www.readbyqxmd.com/read/29066556/seizures-and-sleep-in-the-thalamus-focal-limbic-seizures-show-divergent-activity-patterns-in-different-thalamic-nuclei
#14
Li Feng, Joshua E Motelow, Chanthia Ma, William Biche, Cian McCafferty, Nicholas Smith, Mengran Liu, Qiong Zhan, Ruonan Jia, Bo Xiao, Alvaro Duque, Hal Blumenfeld
The thalamus plays diverse roles in cortical-subcortical brain activity patterns. Recent work suggests that focal temporal lobe seizures depress subcortical arousal systems and convert cortical activity into a pattern resembling slow wave sleep. The potential simultaneous and paradoxical role of the thalamus in both limbic seizure propagation, and in sleep-like cortical rhythms has not been investigated. We recorded neuronal activity from the central lateral (CL), anterior (ANT) and ventral posteromedial (VPM) nuclei of the thalamus in an established female rat model of focal limbic seizures...
October 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29064336/the-effect-of-dim-light-at-night-on-cerebral-hemodynamic-oscillations-during-sleep-a-near-infrared-spectroscopy-study
#15
Tae-Joon Kim, Byeong Uk Lee, Jun-Sang Sunwoo, Jung-Ick Byun, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Manho Kim, Jong-Min Lim, Eunil Lee, Sang Kun Lee, Ki-Young Jung
Recent studies have reported that dim light at night (dLAN) is associated with risks of cardiovascular complications, such as hypertension and carotid atherosclerosis; however, little is known about the underlying mechanism. Here, we evaluated the effect of dLAN on the cerebrovascular system by analyzing cerebral hemodynamic oscillations using near-infrared spectroscopy (NIRS). Fourteen healthy male subjects underwent polysomnography coupled with cerebral NIRS. The data collected during sleep with dim light (10 lux) were compared with those collected during sleep under the control dark conditions for the sleep structure, cerebral hemodynamic oscillations, heart rate variability (HRV), and their electroencephalographic (EEG) power spectrum...
October 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29063522/remembering-specific-features-of-emotional-events-across-time-the-role-of-rem-sleep-and-prefrontal-theta-oscillations
#16
Marie Roxanne Sopp, Tanja Michael, Hans-Günter Weeß, Axel Mecklinger
When an episode of emotional significance is encountered, it often results in the formation of a highly resistant memory representation that is easily retrieved for many succeeding years. Recent research shows that beyond generic consolidation processes, rapid eye movement (REM) sleep importantly contributes to this effect. However, the boundary conditions of consolidation processes during REM sleep, specifically whether these extend to source memory, have not been examined extensively. The current study tested the effects of putative consolidation processes emerging during REM sleep and slow wave sleep (SWS) on item and source memory of negative and neutral images, respectively...
October 23, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29049297/functional-connectivity-structure-of-cortical-calcium-dynamics-in-anesthetized-and-awake-mice
#17
Patrick W Wright, Lindsey M Brier, Adam Q Bauer, Grant A Baxter, Andrew W Kraft, Matthew D Reisman, Annie R Bice, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver
The interplay between hemodynamic-based markers of cortical activity (e.g. fMRI and optical intrinsic signal imaging), which are an indirect and relatively slow report of neural activity, and underlying synaptic electrical and metabolic activity through neurovascular coupling is a topic of ongoing research and debate. As application of resting state functional connectivity measures is extended further into topics such as brain development, aging and disease, the importance of understanding the fundamental physiological basis for functional connectivity will grow...
2017: PloS One
https://www.readbyqxmd.com/read/29040758/linking-light-exposure-and-subsequent-sleep-a-field-polysomnography-study-in-humans
#18
Emma J Wams, Tom Woelders, Irene Marring, Laura van Rosmalen, Domien G M Beersma, Marijke C M Gordijn, Roelof A Hut
Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory PSG and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing and architecture. Laboratory salivary dim-light melatonin onset (DLMO) was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2=0...
October 11, 2017: Sleep
https://www.readbyqxmd.com/read/29040275/nocturnal-sleep-mediates-the-relationship-between-morningness-eveningness-preference-and-the-sleep-architecture-of-afternoon-naps-in-university-students
#19
Tzu-Yin Lee, Pi-Chen Chang, Ing-Jy Tseng, Min-Huey Chung
The present study investigated the parameters of nocturnal sleep that mediate the relationship between morningness-eveningness preference and the sleep architecture of naps in university students. This study had a cross-sectional, descriptive correlational design. The sleep architecture of 52 students invited to take an afternoon nap in the laboratory was recorded. The morningness-eveningness questionnaire (MEQ) was used to evaluate morningness-eveningness preference. An actigraph was used to collect students' nighttime sleep data in the week preceding the study...
2017: PloS One
https://www.readbyqxmd.com/read/29035709/heart-rate-variability-and-salivary-cortisol-in-very-preterm-children-during-school-age
#20
Natalie Urfer-Maurer, Sebastian Ludyga, Tobias Stalder, Serge Brand, Edith Holsboer-Trachsler, Markus Gerber, Alexander Grob, Peter Weber, Sakari Lemola
The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study...
October 5, 2017: Psychoneuroendocrinology
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