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https://www.readbyqxmd.com/read/29774882/-sleep-wake-rhythm-after-extracorporeal-circulation-in-new-zealand-rabbits
#1
Kaiwei Wang, Jiaqiang Zhang
To evaluate the change of sleep-wake rhythm after extracorporeal circulation (ECC) in New Zealand rabbits, and to explore the role of clock genes in sleep-wake rhythm disorder by ECC.
 Methods: A total of 54 New Zealand rabbits were randomly divided into 3 groups: a normal group (Group N), a sham group (Group S) and a model group (Group ECC). Electrocorticogram (ECOG), electroophthalmogram (EOG) and electromyogram (EMG) were respectively recorded by multipurpose EEG recorder, and the sleep-wake rhythm was also recorded...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29758338/how-do-children-fall-asleep-a-high-density-eeg-study-of-slow-waves-in-the-transition-from-wake-to-sleep
#2
Mathilde Spiess, Giulio Bernardi, Salome Kurth, Maya Ringli, Flavia M Wehrle, Oskar G Jenni, Reto Huber, Francesca Siclari
INTRODUCTION: Slow waves, the hallmarks of non-rapid eye-movement (NREM) sleep, are thought to reflect maturational changes that occur in the cerebral cortex throughout childhood and adolescence. Recent work in adults has revealed evidence for two distinct synchronization processes involved in the generation of slow waves, which sequentially come into play in the transition to sleep. In order to understand how these two processes are affected by developmental changes, we compared slow waves between children and young adults in the falling asleep period...
May 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29755349/ibogaine-acute-administration-in-rats-promotes-wakefulness-long-lasting-rem-sleep-suppression-and-a-distinctive-motor-profile
#3
Joaquín González, José P Prieto, Paola Rodríguez, Matías Cavelli, Luciana Benedetto, Alejandra Mondino, Mariana Pazos, Gustavo Seoane, Ignacio Carrera, Cecilia Scorza, Pablo Torterolo
Ibogaine is a potent psychedelic alkaloid that has been the focus of intense research because of its intriguing anti-addictive properties. According to anecdotic reports, ibogaine has been originally classified as an oneirogenic psychedelic; i.e., induces a dream-like cognitive activity while awake. However, the effects of ibogaine administration on wakefulness (W) and sleep have not been thoroughly assessed. The main aim of our study was to characterize the acute effects of ibogaine administration on W and sleep...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29754107/amantadine-a-new-treatment-for-refractory-electrical-status-epilepticus-in-sleep
#4
Rujuta B Wilson, Yazan Eliyan, Raman Sankar, Shaun A Hussain
PURPOSE: Electrical status epilepticus in sleep (ESES) is an electrographic abnormality linked to language abnormalities and cognitive dysfunction and specifically associated with Landau-Kleffner syndrome (LKS), the syndrome of continuous spike and wave in slow-wave sleep (CSWS), and autistic regression with epileptiform EEG (AREE). As first-line therapies for treatment of ESES display inadequate efficacy and confer substantial risk, we set out to describe our center's experience with amantadine in the treatment of ESES...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29750549/does-breaking-up-prolonged-sitting-when-sleep-restricted-affect-postprandial-glucose-responses-and-subsequent-sleep-architecture-a-pilot-study
#5
Grace E Vincent, Sarah M Jay, Charli Sargent, Katya Kovac, Michele Lastella, Corneel Vandelanotte, Nicola D Ridgers, Sally A Ferguson
This pilot study investigated the impact of breaking up prolonged sitting with light-intensity walking on postprandial glucose responses and sleep architecture. In a randomized, counterbalanced, crossover design, six healthy males completed a sitting condition and an active condition (sitting interrupted with light-intensity walking) for three consecutive days, following 5-h sleep opportunities at night. Postprandial glucose response and sleep (time spent in all stages) was assessed. Breaking up prolonged sitting with light-intensity walking did not affect postprandial glucose responses in sleep-restricted participants; however a small increase (~9 min) in slow-wave sleep was observed...
May 11, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29739092/satb2-associated-syndrome-a-case-report-of-a-de-novo-nonsense-mutation-in-satb2-from-china-and-review-of-literature
#6
Hong-Yan Lv, Rui-Jiang Zheng, Qiu-Li Wang, Peng-Shun Ren, Lin-Hong Jin, Xiu-Ling Gu, Lian-Xiang Li
BACKGROUND: To study the clinical and genetic features from a Chinese child with SATB2-associated syndrome (SAS) and review of literature. METHODS: The girl, 2 years 3 months old, is admitted to the Department of Pediatric Rehabilitation in our hospital. This patient has mental retardation, language development disorder, cleft palate II0, micrognathia, malocclusion, irritability and bilateral oblique palpebral fissure as a clinical manifestation and is treated for 3 months...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737605/chronic-high-caloric-diet-modifies-sleep-homeostasis-in-mice
#7
Maria Panagiotou, Johanna H Meijer, Tom Deboer
Obesity prevalence and sleep habit changes are commonplace nowadays, due to modern lifestyle. A bidirectional relationship likely exists between sleep quality and metabolic disruptions, that could impact quality of life. In our study, we investigated the effects of a chronic high-caloric diet on sleep architecture and sleep regulation in mice. We studied the effect of three months high-caloric diet (HCD, 45% fat) on sleep and the sleep electroencephalogram (EEG) in C57BL/6J mice during 24-h baseline (BL) recordings, and after 6-h sleep deprivation (SD)...
May 8, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29726641/-impact-of-deep-slow-wave-sleep-deprivation-on-oxidative-stress-response-of-the-testis-tissue-in-rats
#8
Fei Xu, Na Yang, Yu-Han Liang, Qi-Jin He, Mei-Wen Zhang, Zi-Han Wang, Yi-Wei Shen, Hai-Zheng Li, Xue-Qian Wang, Lai-Xiang Lin
Objective: To investigate the influence of deep slow-wave sleep deprivation on the oxidative stress of testicular tissue in rats. METHODS: Thirty-six 5-week-old male Wistar rats were equally randomized into deep slow-wave sleep deprivation group (SD1), deep slow-wave sleep and duration sleep deprivation group ( SD2), and a cage control group (CC). The rat model of deep slow-wave sleep deprivation was established using the flowerpot technique. The rats in the SD1 group were interfered every 24 minutes and deprived of 12 hours of sleep at night, those in the SD2 group deprived of 8 minutes of sleep at an interval of 24 minutes and 12 hours of sleep at night, and those in the CC group exposed to 12 hours of daylight and 12 hours of darkness...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29722893/response-to-chronic-sleep-restriction-extension-and-total-sleep-deprivation-in-humans-adaptation-or-preserved-sleep-homeostasis
#9
Jelena Skorucak, Emma Arbon, Derk-Jan Dijk, Peter Achermann
Sleep is regulated by a homeostatic process which in the two-process model of human sleep regulation is represented by EEG slow-wave activity (SWA). Many studies of acute manipulation of wake duration have confirmed the precise homeostatic regulation of SWA in rodents and humans. However, some chronic sleep restriction studies in rodents show that the sleep homeostatic response, as indexed by SWA, is absent or diminishes suggesting adaptation occurs. Here, we investigate the response to 7 days of sleep restriction (6 h time in bed) and extension (10 h time in bed) as well as the response to subsequent total sleep deprivation in 35 healthy participants in a cross-over design...
May 2, 2018: Sleep
https://www.readbyqxmd.com/read/29722079/electrodermal-activity-patterns-in-sleep-stages-and-their-utility-for-sleep-versus-wake-classification
#10
Anne Herlan, Jörg Ottenbacher, Johannes Schneider, Dieter Riemann, Bernd Feige
As the prevalence of sleep disorders is increasing, new methods for ambulatory sleep measurement are required. This paper presents electrodermal activity in different sleep stages and a sleep detection algorithm based on electrodermal activity. We analysed electrodermal activity and polysomnographic data of 43 healthy subjects and 48 patients with sleep disorders. Electrodermal activity was measured using an ambulatory device worn at the wrist. Two parameters to describe electrodermal activity were defined based on previous literature: EDASEF (electrodermal activity-smoothed feature) as parameter for skin conductance level; and EDAcounts (number of electrodermal activity-peaks) as skin conductance responses...
May 2, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29718878/fatal-familial-insomnia-presenting-with-agrypnia-excitata-and-very-low-atonia-index-level-a-case-report-and-literature-review
#11
Tae-Won Yang, Byeongsu Park, Keun Tae Kim, Jin-Sun Jun, Young-Soo Kim, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee, Ki-Young Jung
RATIONALE: Fatal familial insomnia (FFI) is a human prion disease that is characterized by sleep-wake cycle deterioration, loss of slow-wave sleep, and motor overactivation over the daily 24-hour period. PATIENT CONCERNS: Here, we report the case of a 57-year-old man who had an irregular sleep-wake cycle and exhibited frequent movements and vocalizations during sleep. DIAGNOSES: Video-polysomnography showed disrupted sleep structure, rapid alternation between sleep stages, and an absence of sleep spindles and slow-wave sleep...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29704647/preferential-consolidation-of-emotionally-salient-information-during-a-nap-is-preserved-in-middle-age
#12
Sara E Alger, Elizabeth A Kensinger, Jessica D Payne
Sleep preferentially preserves aspects of memory that are most salient and valuable to remember at the expense of memory for less relevant details. Daytime naps and nocturnal sleep enhance this emotional memory trade-off effect, with memory for emotional components correlated with slow-wave sleep during the day and rapid eye movement sleep overnight. However, these studies have primarily sampled from young adult populations. Sleep and memory are altered by middle age, and the aim of the present study was to examine how age affects sleep-based mechanisms of emotional memory prioritization, using a daytime nap protocol to compare young to middle-aged adults...
April 4, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29697841/cortical-region-specific-sleep-homeostasis-in-mice-effects-of-time-of-day-and-waking-experience
#13
Mathilde C C Guillaumin, Laura E McKillop, Nanyi Cui, Simon P Fisher, Russell G Foster, Maarten de Vos, Stuart N Peirson, Peter Achermann, Vladyslav V Vyazovskiy
Sleep-wake history, wake behaviours, lighting conditions and circadian time influence sleep, but neither their relative contribution, nor the underlying mechanisms are fully understood. The dynamics of EEG slow-wave activity (SWA) during sleep can be described using the two-process model, whereby the parameters of homeostatic Process S are estimated using empirical EEG SWA (0.5-4 Hz) in non-rapid eye movement sleep (NREM), and the 24-h distribution of vigilance states. We hypothesised that the influence of extrinsic factors on sleep homeostasis, such as the time of day or wake behaviour, would manifest in systematic deviations between empirical SWA and model predictions...
April 25, 2018: Sleep
https://www.readbyqxmd.com/read/29684437/sleep-dysfunction-following-neonatal-ischemic-seizures-are-differential-by-neonatal-age-of-insult-as-determined-by-qeeg-in-a-mouse-model
#14
S K Kang, S Ammanuel, S Thodupunuri, D A Adler, M V Johnston, S D Kadam
Neonatal seizures associated with hypoxic-ischemic encephalopathy (HIE) pose a challenge in their acute clinical management and are often followed by long-term neurological consequences. We used a newly characterized CD-1 mouse model of neonatal ischemic seizures associated with age-dependent (P7 vs. P10) seizure severity and phenobarbital efficacy (i.e.; PB-resistant vs. PB-efficacious respectively) following unilateral carotid ligation. The long-term consequences following untreated neonatal seizures in P7 vs...
April 20, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29680423/nocturnal-sleep-architecture-in-idiopathic-hypersomnia-a-systematic-review-and-meta-analysis
#15
David T Plante
BACKGROUND: Current sleep medicine nosology places increased importance on nocturnal polysomnographic sleep recordings in the diagnosis of central nervous system disorders of hypersomnolence, particularly idiopathic hypersomnia (IH). OBJECTIVE: Determine what differences in sleep staging and architecture exist between IH and healthy controls using meta-analysis. METHODS: Systematic review identified relevant studies that included nocturnal polysomnography data for IH and healthy control groups...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29674729/in-vitro-cortical-network-firing-is-homeostatically-regulated-a-model-for-sleep-regulation
#16
Sohrab Saberi-Moghadam, Alessandro Simi, Hesam Setareh, Cyril Mikhail, Mehdi Tafti
Prolonged wakefulness leads to a homeostatic response manifested in increased amplitude and number of electroencephalogram (EEG) slow waves during recovery sleep. Cortical networks show a slow oscillation when the excitatory inputs are reduced (during slow wave sleep, anesthesia), or absent (in vitro preparations). It was recently shown that a homeostatic response to electrical stimulation can be induced in cortical cultures. Here we used cortical cultures grown on microelectrode arrays and stimulated them with a cocktail of waking neuromodulators...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667182/breathing-regulation-and-blood-gas-homeostasis-after-near-complete-lesions-of-the-retrotrapezoid-nucleus-in-adult-rats
#17
George M P R Souza, Roy Kanbar, Daniel S Stornetta, Stephen B G Abbott, Ruth L Stornetta, Patrice G Guyenet
The retrotrapezoid nucleus (RTN) is one of several CNS nuclei that contribute, in various capacities (e.g. CO2 detection, neuronal modulation) to the central respiratory chemoreflex (CRC). Here we test how important the RTN is to PCO2 homeostasis and breathing during sleep or wake. RTN Nmb positive neurons were killed with targeted microinjections of substance-P-saporin conjugate in adult rats. Under normoxia, rats with large RTN lesions (92 ± 4 % cell loss) had normal blood pressure (BP) and arterial pH but were hypoxic (-8 mmHg PaO2 ) and hypercapnic (+10 mmHg PaCO2 )...
April 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29666574/local-use-dependent-sleep-in-wakefulness-links-performance-errors-to-learning
#18
Angelica Quercia, Filippo Zappasodi, Giorgia Committeri, Michele Ferrara
Sleep and wakefulness are no longer to be considered as discrete states. During wakefulness brain regions can enter a sleep-like state (off-periods) in response to a prolonged period of activity (local use-dependent sleep). Similarly, during nonREM sleep the slow-wave activity, the hallmark of sleep plasticity, increases locally in brain regions previously involved in a learning task. Recent studies have demonstrated that behavioral performance may be impaired by off-periods in wake in task-related regions...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29666271/desynchronization-of-slow-oscillations-in-the-basal-ganglia-during-natural-sleep
#19
Aviv D Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29660400/hippocampal-coupling-with-cortical-and-subcortical-structures-in-the-context-of-memory-consolidation
#20
Ivan Skelin, Scott Kilianski, Bruce L McNaughton
Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures...
April 13, 2018: Neurobiology of Learning and Memory
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