Pauline Brochet, Barbara Ianni, João P S Nunes, Amanda F Frade, Priscila C Teixeira, Charles Mady, Ludmila R P Ferreira, Andreia Kuramoto, Cristina W Pissetti, Bruno Saba, Darlan D S Cândido, Fabrício Dias, Marcelo Sampaio, José A Marin-Neto, Abílio Fragata, Ricardo C F Zaniratto, Sergio Siqueira, Giselle D L Peixoto, Vagner O C Rigaud, Paula Buck, Rafael R Almeida, Hui Tzu Lin-Wang, André Schmidt, Martino Martinelli, Mario H Hirata, Eduardo Donadi, Virmondes Rodrigues Junior, Alexandre C Pereira, Jorge Kalil, Lionel Spinelli, Edecio Cunha-Neto, Christophe Chevillard
Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of people develop chronic forms, including Chronic Chagas Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form: the moderate form, characterized by a heart ejection fraction (EF) ≥ 0.4, and the severe form, associated to an EF < 0.4. We propose two sets of DNA methylation biomarkers which can predict in blood CCC occurrence, and CCC stage...
2022: Frontiers in Immunology