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JOURNAL ARTICLE
Noam E Kopmar, Kim Quach, Ted A Gooley, Christen H Martino, Sindhu Cherian, Mary-Elizabeth M Percival, Anna B Halpern, Cristina M Ghiuzeli, Vivian G Oehler, Janis L Abkowitz, Roland B Walter, Ryan D Cassaday
IMPORTANCE: Options for adults with relapsed or refractory B-cell acute lymphoblastic leukemia or lymphoma (B-ALL) are limited, and new approaches are needed. Inotuzumab ozogamicin (InO) has been combined with low-intensity chemotherapy, with modest improvements over historical controls, and dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) treatment is safe and active for newly diagnosed ALL. OBJECTIVE: To assess the safety and clinical activity of DA-EPOCH and InO in adults with relapsed or refractory B-ALL...
May 9, 2024: JAMA Oncology
#2
JOURNAL ARTICLE
Jun Wang, Dong Mao, BeiChen Dai, YongJun Rui
Background: Injury of peripheral nerve capable of regeneration with much poorer prognosis affects people's life quality. The recovery of nerve function after transplantation for peripheral nerve injury remain a worldwide problem. Silicon-induced biofilms as vascularized biological conduits can promote nerve regeneration by encapsulating autologous or allogeneic nerve graft. Objective: We proposed to explore the effect of silicon-induced biofilms on nerves regeneration and whether the VEGF/VEGFR2/ERK pathway was involved in the present study...
May 9, 2024: Neurological Research
#3
JOURNAL ARTICLE
Yoshiko Atsuta, Helen Baldomero, Daniel Neumann, Anna Sureda, Jakob D DeVos, Minako Iida, Amado Karduss, Duncan Purtill, Alaa M Elhaddad, Nosa G Bazuaye, Carmem Bonfim, Rafael De la Camara, Naeem A Chaudhri, Fabio Ciceri, Cinthya Correa, Cristobal Frutos, Sebastian Galeano, Laurent Garderet, Oscar Gonzalez-Ramella, Raffaella Greco, Nada Hamad, Mette D Hazenberg, Mary M Horowitz, Krzysztof Kalwak, Bor-Sheng Ko, Yoshihisa Kodera, Mickey Bc Koh, Kaiyan Liu, Donal P McLornan, Joon Ho Moon, Benedicte Neven, Shinichiro Okamoto, Marcelo C Pasquini, Jakob R Passweg, Kristjan Paulson, Damiano Rondelli, Annalisa Ruggeri, Adriana Seber, John A Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Hildegard Greinix, Wael Saber, Mahmoud Aljurf, Dietger Niederwieser
Promoting access to and excellence in hematopoietic cell transplantation (HCT) by collecting and disseminating data on global HCT activities is one of the principal activities of the Worldwide Network for Blood and Marrow Transplantation, a non-Governmental organization in working relations with the World Health Organization. HCT activities are recorded annually by member societies, national registries and individual centers including indication, donor type (allogeneic/autologous), donor match and stem cell source (bone marrow/peripheral blood stem cells/cord blood)...
May 9, 2024: Haematologica
#4
Olivia Ziegler, Neekita R Jikaria, Joseph Cioccio, Jeffery S Scow
Graft-versus-host disease (GvHD) is a common complication following hematopoietic stem cell transplant (HSCT) and has protean manifestations. It results from the activation of transplanted T lymphocytes against the HLA antigens of recipient cells, resulting in tissue destruction. The most commonly involved sites of acute GvHD are the skin and gut, with high mortality reported in the latter. Historically, surgery for gut GvHD has been reserved for those with frank perforations or uncontrolled hemorrhage. Here, we present a case of steroid and ruxolitinib refractory colonic GvHD in a 41-year-old female, which was ultimately managed with robotic-assisted total abdominal colectomy with resolution of enteric symptoms...
April 2024: Curēus
#5
JOURNAL ARTICLE
Nhi T Tran, Tayla R Penny, Kyra Yy Chan, Tanya Tang, Paris C Papagianis, Tara Sepehrizadeh, Lakshmi Nekkanti, Valerie A Zahra, Yen Pham, Tamara Yawno, Ilias Nitsos, Sharmony B Kelly, Alison M Thiel, Michael de Veer, Dhafer M Alahmari, Michael C Fahey, Graham Jenkin, Suzanne L Miller, Robert Galinsky, Graeme R Polglase, Courtney A McDonald
BACKGROUND: Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the potential for early administration to optimise their therapeutic capacities. As preterm infants often require ventilatory support, which can contribute to preterm brain injury, we investigated the efficacy of early UCB cell administration following ventilation to reduce white matter inflammation and injury. METHODS: Preterm fetal sheep (0...
May 8, 2024: Journal of Neuroinflammation
#6
Camilla Frieri, Antoine Poli, Marie Balsat, Flore Sicre de Fontbrune
No abstract text is available yet for this article.
April 18, 2024: Hematology, Transfusion and Cell Therapy
#7
JOURNAL ARTICLE
Aleksandra Kaszyńska, Małgorzata Kępska-Dzilińska, Inga Drożak, Ewa Karakulska-Prystupiuk, Agnieszka Tomaszewska, Grzegorz Władysław Basak, Marcin Żórawski, Jolanta Małyszko
Hematopoietic stem cell transplantation could be complicated by acute kidney injury and chronic kidney disease. It may be due to either previous chemotherapy or exposure to a variety of nephrotoxic drug or other causes. The aim of the study was to assess biomarkers of kidney injury in patients at least 3 months after hematopoetic stem cell transplantation (HSCT) under ambulatory care of the Hematology, Transplantation and Internal Medicine Department. We studied 80 prevalent patients after allogeneic HSCT and 32 healthy volunteers to obtain normal ranges of biomarkers...
May 7, 2024: Transplantation Proceedings
#8
REVIEW
Rei Matsumoto, Tomoaki Kato
The traditional procedure for multivisceral transplant (MVT) is to transplant the stomach, pancreas, intestine, and liver en bloc. During surgery, the native spleen is routinely removed from the recipient, and it usually creates more space in the abdomen to insert the allogeneic graft. Thus, recipients often become asplenic after MVT. Considering all of the risks and benefits, we advocate that temporary transplant of the donor spleen could be the best option for MVT recipients; it could potentially reduce the rate of intestinal allograft rejection without increasing the risk for graft-versus-host disease...
June 2024: Gastroenterology Clinics of North America
#9
JOURNAL ARTICLE
Takaaki Konuma, Megumi Hamatani-Asakura, Maki Monna-Oiwa, Seiko Kato, Masamichi Isobe, Kazuaki Yokoyama, Satoshi Takahashi, Yasuhito Nannya
BACKGROUND: Interleukin-2 (IL-2) is one of the most important cytokines that regulate the activation and proliferation of T cells and natural killer cells. The production of IL-2 may be affected by polymorphisms in the promoter region of the IL-2 gene (rs2069762). In allogeneic hematopoietic cell transplantation (HCT) from adult donors, rs2069762 has been associated with the incidence of acute and chronic graft-versus-host disease (GVHD). However, the impacts of IL-2 polymorphism on cord blood transplantation (CBT) outcomes remain unclear...
May 7, 2024: Cytokine
#10
REVIEW
L Q Cao, X D Mo
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non Hodgkin's lymphoma. The current treatment plan can significantly improve the prognosis of patients, but about 30%-40% of DLBCL patients still experience drug resistance and relapse after treatment. For patients with refractory/relapse DLBCL, clinical treatment remains difficult and their prognosis is poor. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains one of the most important curative methods for refractory/relapse DLBCL patients...
March 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#11
JOURNAL ARTICLE
Q Q Xiao, X L Yu, X C Song, Y X Hou, L Deng, W J Li, F Zhou
Objective: To analyze the efficacy of allo-HSCT with total body irradiation (TBI) and chemotherapy alone in the treatment of adult ALL and to explore the factors affecting prognosis. Methods: The clinical data of 95 adult patients with ALL who underwent allo-HSCT from January 2015 to August 2022 were included. According to the conditioning regimen, the patients were divided into two groups: the TBI plus cyclophosphamide (TBI/Cy) group ( n =53) and the busulfan plus cyclophosphamide (Bu/Cy) group ( n =42). Hematopoietic reconstitution after transplantation, GVHD, transplantation-related complications, relapse rate (RR), non-relapse mortality (NRM), OS, and LFS were compared, and the factors related to prognosis were analyzed...
March 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#12
JOURNAL ARTICLE
[Clinical study of the cytokine panel in the diagnosis of ocular chronic graft-versus-host disease].
X J Cheng, R Ji, R H Huan, S Q Huang, W Fan, Y C Zhao, R D Yuan, X Q Wang, X Zhang
Objective: To investigate the association between cytokines and ocular chronic graft-versus-host disease (cGVHD) and identify specific biomarkers for ocular cGVHD to enhance clinical diagnosis, treatment, and evaluation. Methods: A mouse model of cGVHD was established to explore the correlation between cGVHD and serum cytokines. Based on the findings from the animal experiments and literature review, a panel of 16 cytokine combinations was identified. Enzyme-linked immunosorbent assay (ELISA) was used to compare the cytokine concentrations in the serum and tear samples from patients who underwent allogeneic hematopoietic stem cell transplantation from June 2017 to March 2022 at the Medical Center of Hematology, Xinqiao Hospital, Army Medical University...
March 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#13
Wenguang Jia, Xiaoqin Chen, Jianming Luo, Vikram Sumbly, Hirokazu Kanegane, Yunyan He
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive immune activation and inflammatory response. Conventional immunotherapy and molecular targeted drugs demonstrate varying efficacy. Cytokine storm, the primary pathogenic mechanism of HLH, is driven by interferon-gamma (IFN-γ), interleukin (IL)-2, IL-18, etc., in which IFN-γ plays a critical role in the development of the disease. Emapalumab, a potent IFN-γ inhibitor, effectively reduces the occurrence of cytokine storms in refractory and relapsed HLH...
April 30, 2024: Translational Pediatrics
#14
REVIEW
Y Liu, X J Huang, X D Mo
No abstract text is available yet for this article.
May 1, 2024: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
#15
JOURNAL ARTICLE
Hidehiro Itonaga, Yasushi Miyazaki, Machiko Fujioka, Jun Aoki, Noriko Doki, Tetsuya Nishida, Takahiro Fukuda, Naoyuki Uchida, Yasunori Ueda, Yasufumi Uehara, Yuta Katayama, Shuichi Ota, Toshiro Kawakita, Jun Kato, Ken-Ichi Matsuoka, Tetsuya Eto, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Ken Ishiyama
Poor prognostic factors, such as transfusion dependency and chromosomal risk, need to be considered in the indication of allogeneic hematopoietic cell transplantation (allo-HCT) for patients harboring myelodysplastic syndromes with less than 5% marrow blasts (MDS-Lo). We analyzed the post-transplant outcomes of 1229 MDS-Lo patients who received myeloablative (MAC)(n = 651), reduced-intensity (RIC)(n = 397), and non-myeloablative conditioning (NMAC) regimens (n = 181)...
May 7, 2024: Bone Marrow Transplantation
#16
JOURNAL ARTICLE
Hanna Zielińska, Anna Dukat-Mazurek, Alicja Sadowska-Klasa, Piotr Trzonkowski, Jan Maciej Zaucha, Agnieszka Piekarska
BACKGROUND: Recipient's high resolution HLA typing is required in allogeneic hematopoietic cell transplantation from unrelated donors, as well as for haploidentical family donors. For these purposes, Next-Generation Sequencing (NGS) methods are the gold standard. METHODS: We present a case of a patient with an incorrect HLA typing result caused by the population of circulating lymphoma cells. The first HLA examination was performed from peripheral blood (PB) using NGS in the active phase of diffuse large B-cell lymphoma with bone marrow involvement...
May 6, 2024: Transplantation Proceedings
#17
JOURNAL ARTICLE
Marina Ascunce, Alejandra Coccolo, Yasmina Mozo, Fernando Baquero-Artigao, Paula Rodriguez-Molino, Carlos Toro-Rueda, Paloma García-Clemente, Elena Sánchez-Zapardiel, Eduardo López-Granados, Dolores Corral-Sánchez, David Bueno, Luisa Sisinni, Antonio Pérez-Martínez, Cristina Calvo, Teresa Del Rosal
Hematopoietic stem cell transplant recipients are prone to infectious complications. Infections caused by nontuberculous mycobacteria have increased in adults but literature in children is scarce. We report 6 episodes of disseminated or pulmonary nontuberculous mycobacteria infection among 5 pediatric hematopoietic stem cell transplant recipients. All but one were caused by Mycobacterium avium complex. Four patients died, 2 related to nontuberculous mycobacteria infection.
May 7, 2024: Pediatric Infectious Disease Journal
#18
JOURNAL ARTICLE
Ajda Lenardič, Seraina A Domenig, Joel Zvick, Nicola Bundschuh, Monika Tarnowska-Sengül, Regula Furrer, Falko J Noé, Christine Ling Li Trautmann, Adhideb Ghosh, Giada Bacchin, Pjeter Gjonlleshaj, Xhem Qabrati, Evi Masschelein, Katrien De Bock, Christoph Handschin, Ori Bar-Nur
Satellite cells, the stem cells of skeletal muscle tissue, hold a remarkable regeneration capacity and therapeutic potential in regenerative medicine. However, low satellite cell yield from autologous or donor-derived muscles hinders the adoption of satellite cell transplantation for the treatment of muscle diseases, including Duchenne muscular dystrophy (DMD). To address this limitation, here we investigated whether satellite cells can be derived in allogeneic or xenogeneic animal hosts. First, injection of CRISPR/Cas9-corrected mouse DMD-induced pluripotent stem cells (iPSCs) into mouse blastocysts carrying an ablation system of host satellite cells gave rise to intraspecies chimeras exclusively carrying iPSC-derived satellite cells...
May 7, 2024: Journal of Clinical Investigation
#19
JOURNAL ARTICLE
Albert Y Cheung, Cameron B Reinisch, Joshua H Hou
PURPOSE: The purpose of this study was to describe the use of Descemet membrane anterior keratoplasty (DMAK) with modified allogeneic simple limbal epithelial transplantation to treat a case of partial limbal stem cell deficiency (LSCD) following keratolimbal allograft failure. METHODS: Case report. RESULTS: A 21-year-old woman with autoimmune polyglandular syndrome-related LSCD presented with pain and decreased vision. There was partial failure and recurrence of LSCD after a severe/acute keratolimbal allograft rejection that led to persistent epithelial defects refractory to conservative therapy...
May 3, 2024: Cornea
#20
REVIEW
Chi Gao, Xin Li, Yao Xu, Tongcun Zhang, Haichuan Zhu, Di Yao
Acute myeloid leukaemia (AML) is a fatal and refractory haematologic cancer that primarily affects adults. It interferes with bone marrow cell proliferation. Patients have a 5 years survival rate of less than 30% despite the availability of several treatments, including chemotherapy, allogeneic haematopoietic stem cell transplantation (Allo-HSCT), and receptor antagonist drugs. Allo-HSCT is the mainstay of acute myeloid leukaemia treatment. Although it does work, there are severe side effects, such as graft-versus-host disease (GVHD)...
May 2024: Journal of Cellular and Molecular Medicine
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