keyword
https://read.qxmd.com/read/38522078/impaired-neuronal-macroautophagy-in-the-prelimbic-cortex-contributes-to-comorbid-anxiety-like-behaviors-in-rats-with-chronic-neuropathic-pain
#21
JOURNAL ARTICLE
Su Fu, Haojie Sun, Jiaxin Wang, Shuaixin Gao, Liu Zhu, Kun Cui, Shimeng Liu, Xuetao Qi, Rui Guan, Xiaocen Fan, Qingying Liu, Wen Chen, Li Su, Shuang Cui, Feifei Liao, Fengyu Liu, Catherine C L Wong, Ming Yi, You Wan
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulation in the PrL...
March 24, 2024: Autophagy
https://read.qxmd.com/read/38522025/potential-function-of-3-5-dihydroxy-4-methoxybenzyl-alcohol-from-pacific-oyster-crassostrea-gigas-in-brain-of-old-mice
#22
JOURNAL ARTICLE
MinYu Chen, Min Liu, JingHong Chen, Xinwei Liu, LiWei Tang, Chao Wang, Ziniu Yu, Yang Zhang, Jing Tian
SCOPE: 3,5-Dihydroxy-4-methoxybenzyl alcohol (DHMBA) is found in oyster extracts in recent years and is reported to have antioxidant activity. Although it has been reported to be protective in various models of oxidative stress, the therapeutic effect of DHMBA on neurological damage caused by aging remains to be demonstrated. METHODS AND RESULTS: The present study investigates the potential functions of DHMBA in brain of old C57BL/6J mice and aging cell model...
March 24, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38520470/comparison-of-conventional-anesthesia-nurse-education-and-an-artificial-intelligence-chatbot-chatgpt-intervention-on-preoperative-anxiety-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Musashi Yahagi, Rie Hiruta, Chisato Miyauchi, Shoko Tanaka, Aya Taguchi, Yuichi Yaguchi
PURPOSE: This study aimed to evaluate the effects of an artificial intelligence (AI) chatbot (ChatGPT-3.5, OpenAI) on preoperative anxiety reduction and patient satisfaction in adult patients undergoing surgery under general anesthesia. DESIGN: The study used a single-blind, randomized controlled trial design. METHODS: In this study, 100 adult patients were enrolled and divided into two groups: 50 in the control group, in which patients received standard preoperative information from anesthesia nurses, and 50 in the intervention group, in which patients interacted with ChatGPT...
March 21, 2024: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://read.qxmd.com/read/38519972/the-long-term-intercorrelation-between-post-burn-pain-anxiety-and-depression-a-post-hoc-analysis-of-the-re-energize-double-blind-randomized-multicenter-placebo-controlled-trial
#24
RANDOMIZED CONTROLLED TRIAL
Adriana C Panayi, Daren K Heyland, Christian Stoppe, Marc G Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K Bigdeli, Ulrich Kneser, Dennis P Orgill, Gabriel Hundeshagen
BACKGROUND: Despite the growing prevalence of burn survivors, a gap persists in our understanding of the correlation between acute burn trauma and the long-term impact on psychosocial health. This study set out to investigate the prevalence of long-term pain and symptoms of anxiety and depression in survivors of extensive burns, comparing this to the general population, and identify injury and demographic-related factors predisposing individuals to psychosocial compromise. METHODS: RE-ENERGIZE was an international, double-blinded, randomized-controlled trial that enrolled 1200 patients with partial- or full-thickness burns that required surgical treatment...
March 22, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38519539/interaction-between-fokl-polymorphism-and-vitamin-d-deficiency-in-the-symptoms-of-mental-disorders-in-adults-a-population-based-study
#25
JOURNAL ARTICLE
Thaís da Silva Sabião, Luiz Antônio Alves de Menezes-Júnior, Aline Priscila Batista, Samara Silva de Moura, Adriana Lúcia Meireles, Mariana Carvalho de Menezes, George Luiz Lins Machado-Coelho, Júlia Cristina Cardoso Carraro
Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38518541/nutritional-status-of-women-with-non-metastatic-breast-cancer-receiving-outpatient-chemotherapy
#26
JOURNAL ARTICLE
Júlia Anhoque Cavalcanti Marcarini, Wesley Rocha Grippa, Luiz Claudio Barreto Silva Neto, Olívia Perim Galvão Podestá, Andressa Bolsoni-Lopes, Karolini Zuqui Nunes, Luís Carlos Lopes-Júnior
OBJECTIVES: The aim of this study was to evaluate and compare the nutritional status of women with stage I to III breast cancer in the first and third cycles of outpatient chemotherapy and to identify factors associated with it. METHODS: The prospective longitudinal study was conducted at a Reference Hospital for Cancer Care in Brazil and included women aged ≥18 y diagnosed with stage I to III breast cancer receiving outpatient chemotherapy. Assessments were performed during the 1st and 3rd cycles of chemotherapy, including anthropometric measurements, sociodemographic data, clinical information, and quality of life...
February 29, 2024: Nutrition
https://read.qxmd.com/read/38518395/unique-and-interactive-effects-of-emotion-regulation-difficulties-and-perceived-stress-on-covid-19-traumatic-stress-anxiety-and-safety-behavior-use-a-four-year-prospective-study
#27
JOURNAL ARTICLE
Sarah C Jessup, Alexandra M Adamis, Catherine E Rast, Rebecca C Cox, Bunmi O Olatunji
Given that emotion regulation difficulties confer risk for poor responses to stress, they may predict who is at risk for adverse psychological reactions to major, chronic stressors such as the COVID-19 pandemic. Specific adverse reactions to the pandemic may include more severe traumatic stress, anxiety, and excessive safety behavior use (i.e., hand washing). While emotion regulation difficulties may be a diathesis for adverse reactions to chronic stressors, the context(s) by which they may confer elevated risk is unclear...
March 16, 2024: Behaviour Research and Therapy
https://read.qxmd.com/read/38518270/psychedelic-therapy-a-primer-for-primary-care-clinicians-ibogaine
#28
JOURNAL ARTICLE
Kirsten Cherian, Kenneth Shinozuka, Burton J Tabaac, Alejandro Arenas, Bryce D Beutler, Viviana D Evans, Chelsey Fasano, Owen S Muir
BACKGROUND: Ibogaine is a plant-derived alkaloid that has been used for thousands of years in rites of passage and spiritual ceremonies in West-Central Africa. In the West, it has primarily been used and studied for its anti-addictive properties and more recently for other neuropsychiatric indications, including post-traumatic stress disorder, depression, anxiety, and traumatic brain injury. AREAS OF UNCERTAINTY: Ibogaine requires careful patient screening and monitoring because of significant safety issues...
March 2024: American Journal of Therapeutics
https://read.qxmd.com/read/38516908/meal-related-symptoms-in-youth-with-chronic-abdominal-pain-relationship-to-anxiety-depression-and-sleep-dysfunction
#29
JOURNAL ARTICLE
Achintya Benegal, Hunter Friesen, Jennifer Schurman, Jennifer Colombo, Craig Friesen
OBJECTIVE: The objective of the current study was to describe meal-related symptoms in youth with chronic abdominal pain fulfilling criteria for a disorder of gut-brain interaction (DGBI) and their associations with anxiety, depression, and sleep disturbances. METHODS: This was a retrospective evaluation of 226 consecutive patients diagnosed with an abdominal pain-associated DGBI. As part of routine care, all had completed a standardized symptom history, the Sleep Disturbances Scale for Children (utilized to assess for disorders of initiation and maintenance of sleep and excessive daytime somnolence) and the Behavior Assessment System for Children-Third Edition (utilized to assess for anxiety and depression)...
March 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38516370/maternal-grandmothers-buffer-the-effects-of-ethnic-discrimination-among-pregnant-latina-mothers
#30
JOURNAL ARTICLE
Delaney A Knorr, Molly M Fox
Ethnic discrimination during pregnancy is linked to maternal psychological distress, adverse birth outcomes and increased offspring morbidity and mortality. An evolutionary perspective reframes offspring health issues as a risk to maternal fitness. We argue that kin may be evolutionarily motivated to buffer psychosocial stressors for the mother during pregnancy. Previously, we found that the relationship of a pregnant woman with her own mother (fetus' maternal grandmother) had a positive association on maternal prenatal psychology, above and beyond her relationship with her fetus' father...
2024: Evolutionary human sciences
https://read.qxmd.com/read/38515504/antidepressants-in-people-with-chronic-liver-disease-and-depression-when-are-they-warranted-and-how-to-choose-the-suitable-one
#31
REVIEW
Swapnajeet Sahoo, Eepsita Mishra, Madhumita Premkumar
Most chronic medical illnesses are associated with significant psychiatric comorbidity, especially in the form of depression, anxiety, and suicidality. Chronic liver disease (CLD) is no exception to this and rather is placed uniquely as compared to other diseases because of its intersection with alcohol use disorder and other substance use, which in itself is a mental illness. Patients with CLD may have comorbid psychiatric illnesses; the pharmacokinetic concerns arising out of hepatic dysfunction which affects pharmacotherapy for depression and vice versa...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38515123/humanistic-burden-of-pediatric-type-1-diabetes-on-children-and-informal-caregivers-systematic-literature-reviews
#32
REVIEW
Veleka Allen, Aymeric Mahieu, Ellen Kasireddy, Walid Shouman, Mir-Masoud Pourrahmat, Jean-Paul Collet, Andriy Cherkas
BACKGROUND: Diagnosis of children with type 1 diabetes (T1D) imposes an unprecedented burden on children and their caregivers. OBJECTIVE: To assess the burden of T1D on children and their informal caregivers, both after a recent diagnosis or after a longer duration of disease. METHODS: A series of systematic literature reviews were performed to explore the burden of T1D on children with the disease and their primary informal caregivers, based on the time of diagnosis...
March 21, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38515062/-anxiety-is-not-cute-analysis-of-twitter-users-discourses-on-romanticizing-mental-illness
#33
JOURNAL ARTICLE
Barikisu Issaka, Ebenezer Ato Kwamena Aidoo, Sandra Freda Wood, Fatima Mohammed
BACKGROUND: The proliferation of social media platforms has provided a unique space for discourse on mental health, originally intended to destigmatize mental illness. However, recent discourses on these platforms have shown a concerning shift towards the romanticization of mental health issues. This research focuses on Twitter (now called X) users' authentic discussions on the phenomenon of romanticizing mental health, aiming to uncover unique perspectives, themes, and language used by users when engaging with this complex topic...
March 21, 2024: BMC Psychiatry
https://read.qxmd.com/read/38514800/the-comparative-study-of-chronically-ill-and-healthy-children-and-adolescents-in-the-light-of-their-general-mental-health
#34
JOURNAL ARTICLE
Péter Boris, Karolina Eszter Kovács, Beáta Erika Nagy
Children's hospitalisation is difficult for the family and the immediate environment. In these cases, the provision of psychological support is particularly important. Chronically ill children who are regularly hospitalised are in a particularly difficult situation, often feeling vulnerable. Our research aims to explore and analyse in detail the psychological state, attitudes and mental health of chronically ill children and to compare patient groups (children receiving care in pulmonology, gastroenterology, onco-haematology and rehabilitation) to understand the interacting factors, which may be of great importance for quality patient care and for measures to improve patient care in the future...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514244/wilding-cities-for-biodiversity-and-people-a-transdisciplinary-framework
#35
JOURNAL ARTICLE
Sébastien Bonthoux, Simon Chollet
Accelerating urbanisation and associated lifestyle changes result in loss of biodiversity and diminished wellbeing of people through fewer direct interactions and experiences with nature. In this review, we propose the notion of urban wilding (the promotion of autonomous ecological processes that are independent of historical land-use conditions, with minimal direct human maintenance and planting interventions) and investigate its propensity to improve biodiversity and people-nature connections in cities. Through a large interdisciplinary synthesis, we explore the ecological mechanisms through which urban wilding can promote biodiversity in cities, investigate the attitudes and relations of city dwellers towards urban wild spaces, and discuss the integration of urban wilding into the fabric of cities and its governance...
March 21, 2024: Biological Reviews of the Cambridge Philosophical Society
https://read.qxmd.com/read/38513774/lower-cerebrovascular-reactivity-in-prefrontal-cortex-and-weaker-negative-functional-connectivity-between-prefrontal-cortex-and-insula-contribute-to-white-matter-hyperintensity-related-anxiety-or-depression
#36
JOURNAL ARTICLE
Lili Huang, Xin Liu, Yue Cheng, Ruomeng Qin, Dan Yang, Yuting Mo, Zhihong Ke, Zheqi Hu, Chenglu Mao, Ying Chen, Jingwei Li, Yun Xu
BACKGROUND: White matter hyperintensities (WMHs) are associated with higher anxiety or depression (A/D) incidence. We investigated associations of WMHs with A/D, cerebrovascular reactivity (CVR), and functional connectivity (FC) to identify potential pathomechanisms. METHODS: Participants with WMH (n = 239) and normal controls (NCs, n = 327) were assessed for A/D using the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD)...
March 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38512593/efficacy-of-probiotic-supplements-in-improving-the-symptoms-of-psychosis-anxiety-insomnia-and-anorexia-due-to-amphetamine-and-methamphetamine-use-a-randomized-clinical-trial
#37
JOURNAL ARTICLE
Rahim Badrfam, Atefeh Zandifar, Amirhossein Hajialigol, Maryam Rashidian, Norman Brad Schmidt, Danielle Morabito, Mostafa Qorbani, Ehsan Shahrestanaki, Mahboobeh Mehrabani Natanzi
RATIONALE: Changes in the density and diversity of gut microbiota in chronic use of methamphetamine have been mentioned as contributors to psychotic and anxiety symptoms, sleep problems, and loss of appetite. OBJECTIVE: In this placebo-controlled clinical trial, we investigated the effect of the probiotic Lactobacillus Acidophilus in improving psychiatric symptoms among hospitalized patients with chronic methamphetamine use along with psychotic symptoms. METHODS: 60 inpatients with a history of more than 3 years of methamphetamine use, were randomly assigned to one of two groups receiving either a probiotic capsule or placebo along with risperidone for 8 weeks based on a simple randomization method...
March 21, 2024: Psychopharmacology
https://read.qxmd.com/read/38512380/association-of-mental-health-related-patient-reported-outcomes-with-blood-pressure-in-adults-and-children-with-primary-proteinuric-glomerulopathies
#38
JOURNAL ARTICLE
Matthew Schuchman, Tammy M Brady, Dorey A Glenn, Katherine R Tuttle, Gabriel Cara-Fuentes, Rebecca V Levy, Agustin Gonzalez-Vicente, Fadhl M Alakwaa, Tarak Srivastava, Christine B Sethna
INTRODUCTION: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in primary proteinuric glomerulopathies is not well characterized. This study explored longitudinal relationships between psychosocial patient-reported outcomes and BP status among individuals with proteinuric glomerulopathies. METHODS: An observational cohort study was performed using data from 745 adults and children enrolled in the Nephrotic Syndrome Study Network (NEPTUNE)...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38512063/caregiver-distress-and-child-behavior-problems-in-children-with-developmental-delay-from-predominantly-minoritized-backgrounds
#39
JOURNAL ARTICLE
Brynna H Blanchet, Timothy Hayes, Caroline Gillenson, Keara Neuman, Perrine Heymann, Jonathan S Comer, Daniel M Bagner
IMPORTANCE: Child behavior problems have been shown to contribute to caregiver distress and vice versa among youth with developmental delay (DD). However, studies have not examined these associations among children and caregivers from underrepresented ethnic/racial backgrounds. Furthermore, research has not explored how associations function differently following internet-delivered treatment or based on the level of acculturation and enculturation. OBJECTIVE: We examined bidirectional associations between caregiver distress (i...
March 21, 2024: Journal of Clinical Child and Adolescent Psychology
https://read.qxmd.com/read/38510803/deployment-of-attention-to-facial-expressions-varies-as-a-function-of-emotional-quality-but-not-in-alexithymic-individuals
#40
JOURNAL ARTICLE
Chiara Surber, Dennis Hoepfel, Vivien Günther, Anette Kersting, Michael Rufer, Thomas Suslow, Charlott Maria Bodenschatz
BACKGROUND: Alexithymia is a risk factor for emotional disorders and is characterized by differences in automatic and controlled emotion processing. The multi-stimulus free-viewing task has been used to detect increased negative and reduced positive attentional biases in depression and anxiety. In the present eye-tracking study, we examined whether lexical emotional priming directs attention toward emotion-congruent facial expressions and whether alexithymia is related to impairments in lexical priming and spontaneous attention deployment during multiple face perception...
2024: Frontiers in Psychiatry
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