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https://www.readbyqxmd.com/read/28530339/-health-scares-a-chronicle-unnecessary-anxiety
#1
REVIEW
Iftach Sagy, Dan Greenberg, Alan Jotkowitz, Leonid Barski, Victor Novack
A health scare is an event characterized by fear of catastrophic consequences with little actual results. Regardless of these negligible results, the health, social and economic impacts of such events may be significant. Health scares are spread throughout four major groups: the media, relevant medical experts, policy makers and the public at large. In this review, we described two recent cases in Israel: the case of Eltroxin exchange that occurred in Israel as well as other countries, in addition to the polio virus spread in sewage, in the context of health scares...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28529139/psychopharmacology-of-combined-activation-of-the-serotonin1a-and-%C3%AF-1-receptors
#2
REVIEW
Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
The selective serotonin (5-HT) reuptake inhibitors (SSRIs) are generally used for the treatment of major depressive disorders, and the 5-HT1A and σ1 receptors are considered to be targets for treatment of psychiatric disorders. Some SSRIs such as fluvoxamine have agonistic activity towards for the σ1 receptor, but it is not known whether the effect on the receptor plays a key role in the pharmacological effects. We have recently demonstrated that fluvoxamine shows an anti-anhedonic effect in picrotoxin-induced model of anxiety/depression, while the SSRI paroxetine, which have little affinity for the σ1 receptor, does not...
May 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28528930/clinical-and-psychosocial-predictors-of-urologic-chronic-pelvic-pain-symptom-change-over-one-year-a-prospective-study-from-the-mapp-research-network
#3
Bruce D Naliboff, Alisa J Stephens, H Henry Lai, James W Griffith, J Quentin Clemens, Susan Lutgendorf, Larissa V Rodriguez, Craig Newcomb, Siobhan Sutcliffe, Wensheng Guo, John W Kusek, J Richard Landis
OBJECTIVE: To examine baseline clinical and psychosocial characteristics that predict 12- month symptom change in men and women with urologic chronic pelvic pain syndromes (UCPPS). METHODS: 221 female and 176 male UCPPS patients were recruited from 6 academic medical centers in the United States and evaluated at baseline with a comprehensive battery of symptom, psychosocial, and illness-impact measures. Based on biweekly symptom reports, a functional clustering procedure classified participant's outcome as worse, stable, or improved on pain and urinary symptom severity...
May 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28528457/exposure-to-parents-negative-emotions-as-a-developmental-pathway-to-the-family-aggregation-of-depression-and-anxiety-in-the-first-year-of-life
#4
REVIEW
Evin Aktar, Susan M Bögels
Depression and anxiety load in families. In the present study, we focus on exposure to parental negative emotions in first postnatal year as a developmental pathway to early parent-to-child transmission of depression and anxiety. We provide an overview of the little research available on the links between infants' exposure to negative emotion and infants' emotional development in this developmentally sensitive period, and highlight priorities for future research. To address continuity between normative and maladaptive development, we discuss exposure to parental negative emotions in infants of parents with as well as without depression and/or anxiety diagnoses...
May 20, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/28528227/treatment-non-response-associations-with-smoking-expectancies-among-treatment-seeking-smokers
#5
Lorra Garey, Samar A Taha, Brooke Y Kauffman, Kara F Manning, Clayton Neighbors, Norman B Schmidt, Michael J Zvolensky
Despite the high rate of smoking cessation treatment non-response, relatively little empirical work has examined predictors of treatment non-response. The present study sought to explore the effect of smoking outcome expectancies on treatment response in a sample of treatment-seeking adult daily smokers (N=182; 53.3% female; Mage=40.67; SD=13.63). Results indicated that expectancies for smoking to reduce negative affect were related to an increased likelihood of treatment non-response (OR=0.73, CI: 0.54, 0...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#6
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28525828/peripheral-immune-factors-are-elevated-in-women-with-current-or-recent-alcohol-dependence-and-associated-with-altered-mood-and-memory
#7
Clare J Wilhelm, Bret E Fuller, Marilyn Huckans, Jennifer M Loftis
BACKGROUND: The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. METHODS: Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n=51) or without (n=31) a current or recent history of alcohol dependence...
May 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28525541/safety-behaviors-and-stuttering
#8
Robyn Lowe, Fjola Helgadottir, Ross Menzies, Rob Heard, Sue O'Brian, Ann Packman, Mark Onslow
Purpose: Those who are socially anxious may use safety behaviors during feared social interactions to prevent negative outcomes. Safety behaviors are associated with anxiety maintenance and poorer treatment outcomes because they prevent fear extinction. Social anxiety disorder is often comorbid with stuttering. Speech pathologists reported in a recent publication (Helgadottir, Menzies, Onslow, Packman, & O'Brian, 2014a) that they often recommended procedures for clients that could be safety behaviors...
May 19, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28522735/d3-receptors-regulate-excitability-in-a-unique-class-of-prefrontal-pyramidal-cell
#9
Rebecca L Clarkson, Alayna T Liptak, Steven M Gee, Vikaas S Sohal, Kevin J Bender
The D3 dopamine receptor, a member of the Gi-coupled D2-family of dopamine receptors, is expressed throughout limbic circuits affected in neuropsychiatric disorders, including prefrontal cortex. These receptors are important for prefrontal executive function, as pharmacological and genetic manipulations that affect prefrontal D3 receptors alter anxiety, social interaction, and reversal learning. And yet, the mechanisms by which D3 receptors regulate prefrontal circuits, and whether D3 receptors regulate specific prefrontal subnetworks, remain unknown...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28521247/cognitive-performance-of-juvenile-monkeys-after-chronic-fluoxetine-treatment
#10
Mari S Golub, Edward P Hackett, Casey E Hogrefe, Csaba Leranth, John D Elsworth, Robert H Roth
Potential long term effects on brain development are a concern when drugs are used to treat depression and anxiety in childhood. In this study, male juvenile rhesus monkeys (three-four years of age) were dosed with fluoxetine or vehicle (N=16/group) for two years. Histomorphometric examination of cortical dendritic spines conducted after euthanasia at one year postdosing (N=8/group) suggested a trend toward greater dendritic spine synapse density in prefrontal cortex of the fluoxetine-treated monkeys. During dosing, subjects were trained for automated cognitive testing, and evaluated with a test of sustained attention...
May 1, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28521005/using-directed-acyclic-graphs-in-epidemiological-research-in-psychosis-an-analysis-of-the-role-of-bullying-in-psychosis
#11
Giusi Moffa, Gennaro Catone, Jack Kuipers, Elizabeth Kuipers, Daniel Freeman, Steven Marwaha, Belinda R Lennox, Matthew R Broome, Paul Bebbington
Modern psychiatric epidemiology researches complex interactions between multiple variables in large datasets. This creates difficulties for causal inference. We argue for the use of probabilistic models represented by directed acyclic graphs (DAGs). These capture the dependence structure of multiple variables and, used appropriately, allow more robust conclusions about the direction of causation. We analyzed British national survey data to assess putative mediators of the association between bullying victimization and persecutory ideation...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28515684/selegiline-ameliorates-depression-like-behavior-in-mice-lacking-the-cd157-bst1-gene-a-risk-factor-for-parkinson-s-disease
#12
Satoka Kasai, Toru Yoshihara, Olga Lopatina, Katsuhiko Ishihara, Haruhiro Higashida
Parkinson's disease (PD), a neurodegenerative disorder, is accompanied by various non-motor symptoms including depression and anxiety, which may precede the onset of motor symptoms. Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and is widely used in the treatment of PD and major depression. However, there are few reports about the effects of selegiline on non-motor symptoms in PD. The aim of this study was to explore the antidepressant and anxiolytic effects of selegiline, using CD157/BST1 knockout (CD157 KO) mouse, a PD-related genetic model displaying depression and anxiety, compared with other antiparkinsonian drugs and an antidepressant, and was to investigate the effects of selegiline on biochemical parameters in emotion-related brain regions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28514530/curious-thoughtful-and-affirmative-young-children-s-meanings-of-participation-in-healthcare-situations-when-using-an-interactive-communication-tool
#13
Anna Stålberg, Anette Sandberg, Thomas Larsson, Imelda Coyne, Maja Söderbäck
AIM: to describe young children's demonstrated participation in healthcare situations while using an interactive communication tool. BACKGROUND: participation is a multidimensional concept influenced by situational and contextual issues. In child participation, verbal and non-verbal communicative expressions are of interest, as both demonstrate the child's perspective. Children have a right to participate in all situations that matter to them, for instance healthcare situations...
May 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28513787/does-the-trait-anxiety-affect-the-dental-fear
#14
Yusuf Cetin Doganer, Umit Aydogan, Hande Ucler Yesil, James Edwin Rohrer, Mark Douglas Williams, David Charles Agerter
The aims of the present study were to evaluate possible associations between trait anxiety, dental fear and the predictors of these interactions including demographic characteristics and dental history of patients applied to the dental care center in Ankara, Turkey. A sample of 607 participants (mean age: 21.02 ± 2.32) responded to a Turkish version of the Modified Dental Fear Survey (MDFS), the State-Trait Anxiety Inventory (STAI-T) and a questionnaire regarding previous negative dental experience. Multiple logistic regression analysis was used to identify the association between dental fear and the independent variables including trait anxiety, age groups, education level, dental visit frequency, experience and the source of dental knowledge...
May 4, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28512692/virtual-reality-enhanced-extinction-of-phobias-and-post-traumatic-stress
#15
REVIEW
Jessica L Maples-Keller, Carly Yasinski, Nicole Manjin, Barbara Olasov Rothbaum
Virtual reality (VR) refers to an advanced technological communication interface in which the user is actively participating in a computer-generated 3-dimensional virtual world that includes computer sensory input devices used to simulate real-world interactive experiences. VR has been used within psychiatric treatment for anxiety disorders, particularly specific phobias and post-traumatic stress disorder, given several advantages that VR provides for use within treatment for these disorders. Exposure therapy for anxiety disorder is grounded in fear-conditioning models, in which extinction learning involves the process through which conditioned fear responses decrease or are inhibited...
May 16, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28511978/behavioural-outcomes-of-adult-female-offspring-following-maternal-stress-and-perinatal-fluoxetine-exposure
#16
Veronika Kiryanova, Sara J Meunier, Richard H Dyck
Depression, anxiety, and stress are common in pregnant women. One of the primary pharmacological treatments for anxiety and depression is the antidepressant fluoxetine (Flx). Maternal stress, depression, and Flx exposure are known to effect neurodevelopment of the offspring, however, their combined effects have been scarcely studied, especially in female offspring. The present study investigated the combined effects of maternal stress during pregnancy and perinatal exposure to Flx on the behaviour of female mice as adults...
May 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#17
S Kasper, W E Müller, H P Volz, H J Möller, E Koch, A Dienel
OBJECTIVE: Silexan is a lavender oil preparation available in capsules containing 80 mg. Here we review clinical trials investigating its anxiolytic efficacy, safety, and tolerability in humans as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
May 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28511484/efficacy-of-structured-yoga-intervention-for-sleep-gastrointestinal-and-behaviour-problems-of-asd-children-an-exploratory-study
#18
Kumar Narasingharao, Balaram Pradhan, Janardhana Navaneetham
INTRODUCTION: Autism Spectrum Disorder (ASD) is a neuro developmental disorder which appears at early childhood age between 18 and 36 months. Apart from behaviour problems ASD children also suffer from sleep and Gastrointestinal (GI) problems. Major behaviour problems of ASD children are lack of social communication and interaction, less attention span, repetitive and restrictive behaviour, lack of eye to eye contact, aggressive and self-injurious behaviours, sensory integration problems, motor problems, deficiency in academic activities, anxiety and depression etc...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509622/attachment-insecurity-as-a-mediator-of-the-relationship-between-childhood-trauma-and-adult-dissociation
#19
Seong Sook Kong, Dae Ryong Kang, Min Jung Oh, Nam Hee Kim
This study aimed to investigate whether attachment insecurity mediates the relationship between childhood trauma and adult dissociation, specifically in regards to individual forms of childhood maltreatment. Psychiatric outpatients who visited a specialized trauma clinic (n = 115) participated in the study. Data were collected via the Childhood Trauma Questionnaire, Revised Adult Attachment Scale, and Dissociative Experience Scale. Structural equation modeling and path analysis were performed to analyze the mediating effects of attachment insecurity on the relationship between childhood trauma and adult dissociation...
May 16, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28509583/the-influence-of-attachment-styles-on-sexual-communication-behavior
#20
Julia McNeil, Uzma S Rehman, Erin Fallis
Attachment theory is one of the major theoretical frameworks for understanding romantic relationships. Attachment styles are formed through interactions with caregivers and shape an individual's expectations of subsequent interpersonal relationships. In this study, we examined how attachment styles influence participants' ability to communicate with their partners about problems in their sexual relationship. A community sample of 81 couples engaged in two video-recorded discussions, one representing an aspect of the couple's sexual relationship where the male partner wanted change and the second representing an aspect of the sexual relationship where the female partner wanted change...
May 16, 2017: Journal of Sex Research
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