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https://www.readbyqxmd.com/read/27935776/chronic-postsurgical-pain
#1
Steven R Wooden
Chronic postsurgical pain (CPSP) is defined as a persistent pain state that exists more than 2 months postoperatively and cannot be explained by other causes such as recurrence of disease, apparent inflammation, or other nonsurgical related factors. CPSP is a type of persistent pain condition that often complicates recovery from surgical procedures. It is thought to be caused by surgical nerve injury, but the fact that an identifiable nerve injury can be found in only one-third of CPSP patients suggests that the problem may be far more complex than a simple surgically created nerve injury...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935209/tailoring-the-physicochemical-and-shape-memory-properties-of-the-biodegradable-polymer-poly-glycerol-dodecanoate-via-curing-conditions
#2
Loran D Solorio, Martin L Bocks, Scott J Hollister
A major challenge in the repair and regeneration of soft tissue damage occurring as a result of aging, injury, or disease is recapitulating the biomechanical properties of the native tissue. Ideally, a candidate biomaterial for soft tissue engineering applications should be biocompatible, nonlinearly elastic to match soft tissue mechanical behavior, biodegradable to enable tissue remodeling, and tailorable to achieve a range of nonlinear elastic mechanical properties to match specific soft tissues. In addition, for cardiac and other applications, the biomaterial should have shape memory characteristics to facilitate minimally invasive and/or catheter-based delivery...
December 9, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27933093/long-term-consumption-of-an-obesogenic-high-fat-diet-prior-to-ischemia-reperfusion-mediates-cardioprotection-via-epac1-dependent-signaling
#3
F Edland, A Wergeland, R Kopperud, K S Åsrud, E A Hoivik, S L Witsø, R Æsøy, L Madsen, K Kristiansen, M Bakke, S O Døskeland, A K Jonassen
BACKGROUND: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the "obesity paradox". This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. METHODS: Wild type (wt), Epac1 (Epac1(-/-)) and Epac2 (Epac2(-/-)) deficient mice were fed a high fat (HFD) or normal chow diet (ND) for 33 ± 1 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27932774/-five-cases-of-interstitial-heterotopic-pregnancy-after-ivf-et-treated-by-laparoscopic-surgery
#4
Qiong Pan, Min Xue, Guang Shu
To evaluate the efficency and safety of laparoscopic surgery in the treatment of interstitial heterotopic pregnancy (IHP) after IVF-ET, five patients with interstitial heterotopic pregnancy after IVF-ET treated by laparoscopy in our hospital from Jan. 2012 to Jan. 2015 were retrospectively analyzed. All operations were finished laparoscopically without any major complications and they successfully delivered. The results suggest that laparosccpic surgery is feasible and safe for IHP to maintain the trauterine pregnancy, and it can diagnose and treat IHP at early stage, which cause mininmal injuries and less disturbance to trauterine pregnancy and ensure rapid recovery...
November 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27931776/cd47-deficiency-improves-neurological-outcomes-of-traumatic-brain-injury-in-mice
#5
Song Zhao, Zhanyang Yu, Yu Liu, Yang Bai, Yinghua Jiang, Klaus van Leyen, Yong-Guang Yang, Josephine M Lok, Michael J Whalen, Eng H Lo, Xiaoying Wang
CD47 is a receptor for signal-regulatory protein alpha (SIRPα) in self-recognition by the innate immune system, and a receptor of thrombospondin-1 (TSP-1) contributing to vascular impairment in response to stress. However, the roles of CD47 in traumatic brain injury (TBI) have not been investigated. In this study we aimed to test our hypothesis that CD47 mediates early neutrophil brain infiltration and late brain vascular remodeling after TBI. Mice were subjected to TBI using a controlled cortical impact (CCI) device...
December 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27931505/phase-iii-clinical-trial-assessing-safety-and-efficacy-of-umbilical-cord-blood-mononuclear-cell-transplant-therapy-of-chronic-complete-spinal-cord-injury
#6
Hui Zhu, Waisang Poon, Yansheng Liu, Gilberto Ka-Kit Leung, Yatwa Wong, Yaping Feng, Stephanie C P Ng, Kam Sze Tsang, David T F Sun, David K Yeung, Caihong Shen, Fang Niu, Zhexi Xu, Pengju Tan, Shaofeng Tang, Hongkun Gao, Yun Cha, Kwok-Fai So, Robert Fleischaker, Dongming Sun, John Chen, Jan Lai, Wendy Cheng, Wise Young
Umbilical cord blood-derived mononuclear cell (UCB-MNC) transplants improve recovery in animal spinal cord injury (SCI) models. We transplanted UCB-MNCs into 28 patients with chronic complete SCI in Hong Kong (HK) and Kunming (KM). Stemcyte Inc. donated UCB-MNCs isolated from human leukocyte antigen (HLA 4:6)-matched UCB units. In HK, four patients received four 4-l injections (1.6 million cells) into dorsal entry zones above and below the injury site, and another four received 8-l injections (3.2 million cells)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27931169/a-mouse-model-of-bilateral-cervical-contusion-compression-spinal-cord-injury
#7
Nicole Forgione, Mahmood Chamankhah, Michael Fehlings
Cervical spinal cord injury (cSCI) occurs in over half of all cases of traumatic SCI, yet we lack therapies that can generate significant functional recovery in these patients. The development of animal models of cSCI will aid in the pre-clinical assessment of therapies and in understanding basic pathophysiological mechanisms. Here we describe a clinically relevant model of cervical contusion-compression injury in the mouse. Using a modified aneurism clip we generated a bilateral, incomplete injury that mimics contusion-compression injuries most commonly seen in humans...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27931151/regulation-of-mitochondrial-function-and-glutamatergic-system-are-the-target-of-guanosine-effect-in-traumatic-brain-injury
#8
Fernando Dobrachinski, Rogério da Rosa Gerbatin, Glaubia Sartori, Naiane Ferreira Marques, Ana Paula Pegoraro Zemolin, Luiz Fernando Almeida Silva, Jeferson Luis Franco, Luiz Fernando Freire Royes, Michele Rechia Fighera, Félix Alexandre Antunes Soares
Traumatic brain injury (TBI) is a highly complex multi-factorial disorder. Experimental trauma involves primary and secondary injury cascades that underlie delayed neuronal dysfunction and death. Mitochondrial dysfunction and glutamatergic excitotoxicity are the most important mechanisms of damage. In order to be successful, pharmacologic intervention requires a multifaceted approach. Guanosine (GUO) is known for its neuromodulator effects in different models of brain pathology, which regulates the glutamatergic system...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27930553/the-effects-of-hyaluronic-acid-on-hemiplegic-shoulder-injury-and-pain-in-patients-with-subacute-stroke-a-randomized-controlled-pilot-study
#9
Yu-Chi Huang, Chau-Peng Leong, Lin Wang, Mei-Ju Chen, Chien-Yi Chuang, Mei-Yun Liaw, Lin-Yi Wang
BACKGROUND: Hemiplegic shoulder pain (HSP) is one of the most common comorbidities in stroke patients with flaccid shoulders. The pain limits functional motor recovery and affects the activities of daily living after acute stroke. This study investigated the effects of hyaluronic acid (HA) injection on pain reduction and motor function in subacute stroke patients with HSP and injury. METHODS: A randomized, double-blinded controlled trial was conducted in a medical center...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929325/social-competence-in-pediatric-burn-survivors-a-systematic-review
#10
Margo M Szabo, Kaitlyn A Ferris, Lauryn Urso, Ariel M Aballay, Christina L Duncan
OBJECTIVE: Youth sustaining burn injuries during childhood have dramatically increased survival rates due to improvements in medical treatment and multidisciplinary approaches to burn critical care and recovery. Despite positive advancements in burn treatment, youth sustaining such injuries may experience social deficits. Thus, this systematic review without meta-analysis investigation contributes to the growing literature on this topic by comparing social competence of pediatric burn survivors to youth without burns, and examining potential correlates of social competence among children and adolescents who have sustained burn injuries...
December 8, 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27929116/a-proteolytic-modification-of-aim-promotes-its-renal-excretion
#11
Tomoko Yamazaki, Ryoichi Sugisawa, Emiri Hiramoto, Ryosuke Takai, Ayaka Matsumoto, Yoshie Senda, Katsuhiko Nakashima, Peter S Nelson, Jared M Lucas, Andrew Morgan, Zhenghua Li, Ken-Ichi Yamamura, Satoko Arai, Toru Miyazaki
Apoptosis inhibitor of macrophage (AIM, encoded by cd5l) is a multi-functional circulating protein that has a beneficial role in the regulation of a broad range of diseases, some of which are ameliorated by AIM administration in mice. In blood, AIM is stabilized by association with IgM pentamers and maintains its high circulating levels. The mechanism regulating the excessive accumulation of blood AIM remains unknown, although it is important, since a constitutive increase in AIM levels promotes chronic inflammation...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928735/linking-acute-kidney-injury-to-chronic-kidney-disease-the-missing-links
#12
REVIEW
Mohammed A Kaballo, Mohamed E Elsayed, Austin G Stack
Acute kidney injury (AKI) is considered to be a major public health problem around the globe, and it is associated with major adverse clinical outcomes and significant health care costs. There is growing evidence suggesting that AKI is associated with the subsequent development of chronic kidney disease (CKD). While recovery of kidney function occurs in the majority of patients surviving an AKI episode, a large number of patients do not recover completely. Similarly, CKD is a well-known risk factor for the development of AKI...
December 7, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27928720/cardioprotection-of-exercise-preconditioning-involving-heat-shock-protein-70-and-concurrent-autophagy-a-potential-chaperone-assisted-selective-macroautophagy-effect
#13
Yang Yuan, Shan-Shan Pan, Yu-Jun Shen
It has been confirmed that exercise preconditioning (EP) has a protective effect on acute cardiovascular stress. However, how Hsp70 participates in EP-induced cardioprotection is unknown. EP may involve Hsp70 to repair unfolded proteins or may also stabilize the function of the endoplasmic reticulum via Hsp70-related autophagy to work on a protective formation. Our EP protocol involves four periods of 10 min running with 10 min recovery intervals. We added a period of exhaustive running to test this protective effect, using histology and molecular biotechnology methods to detect related markers...
December 7, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27928652/enhanced-proteostasis-in-post-ischemic-stroke-mouse-brains-by-ubiquilin-1-promotes-functional-recovery
#14
Yanying Liu, Fangfang Qiao, Hongmin Wang
Stroke is pathologically associated with oxidative stress, protein damage, and neuronal loss. We previously reported that overexpression of a ubiquitin-like protein, ubiquilin-1 (Ubqln), protects neurons against ischemia-caused brain injury, while knockout of the gene exacerbates cerebral ischemia-caused neuronal damage and delays functional recovery. Although these observations indicate that Ubqln is a potential therapeutic target, transgenic manipulation-caused overexpression of Ubqln occurs before the event of ischemic stroke, and it remains unknown whether delayed Ubqln overexpression in post-ischemic brains within a clinically relevant time frame is still beneficial...
December 7, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27928029/local-changes-in-network-structure-contribute-to-late-communication-recovery-after-severe-brain-injury
#15
Daniel J Thengone, Henning U Voss, Esteban A Fridman, Nicholas D Schiff
Spontaneous recovery of brain function after severe brain injury may evolve over a long time period and is likely to involve both structural and functional reorganization of brain networks. We longitudinally tracked the recovery of communication in a patient with severe brain injury using multimodal brain imaging techniques and quantitative behavioral assessments measured at the bedside over a period of 2 years and 9 months (21 months after initial injury). Structural diffusion tensor imaging revealed changes in brain structure across interhemispheric connections and in local brain regions that support language and visuomotor function...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27927955/gpr126-adgrg6-has-schwann-cell-autonomous-and-nonautonomous-functions-in-peripheral-nerve-injury-and-repair
#16
Amit Mogha, Breanne L Harty, Dan Carlin, Jessica Joseph, Nicholas E Sanchez, Ueli Suter, Xianhua Piao, Valeria Cavalli, Kelly R Monk
: Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27927055/improving-the-therapeutic-efficacy-of-neural-progenitor-cell-transplantation-following-spinal-cord-injury
#17
Michael A Lane, Angelo C Lepore, Itzhak Fischer
There have been a wide range of preclinical studies testing cellular therapies to repair the injured spinal cord, yet they remain a challenge to translate because of inconsistencies in efficacy, difficulties in obtaining reliable and safe sources of donor cells, limited number of patients with acute/subacute SCI and the high costs of clinical trials. Area covered: This paper focusses on the therapeutic potential of neural precursor cells (NPCs) because they can provide the cellular components capable of promoting repair and enhancing functional improvement following spinal cord injury (SCI)...
December 7, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27927015/isolated-oculomotor-nerve-palsy-in-patients-with-mild-head-injury
#18
Tamara Tajsic, Angelos G Kolias, Tilak Das, Daniel Scoffings, Brinda Muthusamy, Matthew R Garnett, Peter J A Hutchinson
Isolated oculomotor nerve palsy following head injury is uncommon. It can only be diagnosed with confidence if it is known to have developed immediately following trauma and if adequate investigations exclude secondary causes. The recovery is only partial and this has repercussion on patients' quality of life.
December 7, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27925241/vertebral-subluxation-repair-in-a-pet-goat
#19
Sara Nannarone, Enrico Bellezza, Yves P Moens, Paula Larenza Menzies
OBJECTIVES: To describe the perioperative management, including surgery, anesthesia, metabolic derangements, and physiotherapy, in a goat referred for paraparesis secondary to a road traffic accident. STUDY DESIGN: Case report. ANIMALS: 2-year-old mixed breed dwarf 44 kg female pet goat. METHODS: Clinical examination showed symptoms of early compensatory stages of shock, paraparesis with hyperextension of the thoracic limbs, pain on palpation of the thoracolumbar spine, increased patellar reflexes of both pelvic limbs without superficial sensitivity, but preserved deep pain sensation...
December 7, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27924614/gdf11-treatment-attenuates-the-recovery-of-skeletal-muscle-function-after-injury-in-older-rats
#20
Yu Zhou, Neel Sharma, David Dukes, Maria B Myzithras, Priyanka Gupta, Ashraf Khalil, Julius Kahn, Jennifer S Ahlberg, David B Hayes, Michael Franti, Tracy Criswell
Loss of skeletal muscle mass and function results in loss of mobility for elderly patients. Novel therapies that can protect and/or restore muscle function during aging would have profound effects on the quality of life for this population. Growth differentiation factor 11 (GDF11) has been proposed as a "youthful" circulating factor that can restore cardiac, neural, and skeletal muscle functions in aging animals. However, conflicting data has been recently published that casts doubt on these assertions. We used a complex rat model of skeletal muscle injury that physiologically mimics injuries seen in patients; to investigate the ability of GDF11 and to enhance skeletal muscle regeneration after injury in older rats...
December 6, 2016: AAPS Journal
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