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https://www.readbyqxmd.com/read/28230931/spatially-assembled-bilayer-cell-sheets-of-stem-cells-and-endothelial-cells-using-thermosensitive-hydrogels-for-therapeutic-angiogenesis
#1
Indong Jun, Taufiq Ahmad, Seongwoo Bak, Joong-Yup Lee, Eun Mi Kim, Jinkyu Lee, Yu Bin Lee, Hongsoo Jeong, Hojeong Jeon, Heungsoo Shin
Although the coculture of multiple cell types has been widely employed in regenerative medicine, in vivo transplantation of cocultured cells while maintaining the hierarchical structure remains challenging. Here, a spatially assembled bilayer cell sheet of human mesenchymal stem cells and human umbilical vein endothelial cells on a thermally expandable hydrogel containing fibronectin is prepared and its effect on in vitro proangiogenic functions and in vivo ischemic injury is investigated. The expansion of hydrogels in response to a temperature change from 37 to 4 °C allows rapid harvest and delivery of the bilayer cell sheet to two different targets (an in vitro model glass surface and in vivo tissue)...
February 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28230791/the-temporal-pattern-flux-and-function-of-autophagy-in-spinal-cord-injury
#2
REVIEW
Kailiang Zhou, Charles A Sansur, Huazi Xu, Xiaofeng Jia
Previous studies have indicated that autophagy plays a critical role in spinal cord injury (SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord injury (IRSCI). However, while the understanding of mechanisms underlying autophagy in SCI has progressed, there remain several controversial points: (1) temporal pattern results of autophagic activation after SCI are not consistent across studies; (2) effect of accumulation of autophagosomes due to the blockade or enhancement of autophagic flux is uncertain; (3) overall effect of enhanced autophagy remains undefined, with both beneficial and detrimental outcomes reported in SCI literature...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230626/resiliency-and-quality-of-life-trajectories-after-injury
#3
Ben L Zarzaur, Teresa M Bell, Stephen A Zanskas
BACKGROUND: Injury can greatly impact patients' long-term quality of life. Resilience refers to an individual's ability to positively adapt after facing stress or trauma. The objective of this study was to examine the relationship between pre-injury resiliency scores and quality of life after injury. METHODS: 225 adults admitted with an injury severity score > 10 but without neurological injury were included. The SF-36 was administered at the time of admission and repeated at 1, 2, 4 and 12 months after injury...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28230006/evaluation-of-the-safety-and-efficacy-of-percutaneous-radiofrequency-ablation-for-treating-multiple-breast-fibroadenoma
#4
Ping Li, Tang Xiao-Yin, Dan Cui, Jia-Chang Chi, Zhi Wang, Tao Wang, Xing-Xing Qi, Bo Zhai
BACKGROUND: This study was conducted to evaluate the safety and efficacy of ultrasound (US)-guided percutaneous radiofrequency ablation (RFA) for multiple breast fibroadenoma as an alternative to surgical resection. PATIENTS AND METHODS: Sixty-five patients with multiple breast fibroadenoma accepted general anesthesia and US-guided percutaneous RFA in our hospital from September 2014 to January 2016. Contrast-enhanced US (CEUS) was used immediately after operation to determine whether the tumor was ablated completely...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229936/neurons-of-the-rat-cervical-spinal-cord-express-vimentin-and-neurofilament-after-intraparenchymal-injection-of-kainic-acid
#5
Fabián Nishida, Susana M Sisti, Carolina N Zanuzzi, Claudio G Barbeito, Enrique L Portiansky
Intermediate filaments (IF) can be altered under disorders such as neurodegenerative diseases. Kainic acid (KA) induce behavioral changes and histopathological alterations of the spinal cord of injected rats. Our goal was to evaluate the IF expression in neurons during this injury model. Animals were injected with KA at the C5 segment of the cervical spinal cord and euthanized at 1, 3 and 7 post injection (pi) days. Neuronal cell counting showed a significant loss of neurons at the injection site when compared with those of sham and non-operated animals...
February 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28229457/randomized-controlled-trial-of-local-progesterone-vs-corticosteroid-injection-for-carpal-tunnel-syndrome
#6
S A Raeissadat, S Shahraeeni, L Sedighipour, B Vahdatpour
OBJECTIVES: A number of studies have demonstrated the neuroprotective effects of progesterone and its influence on the recovery after neural injury. Few studies investigated the efficacy of local progesterone in carpal tunnel syndrome. The objective of this study was to compare the long-term effects of progesterone vs corticosteroid local injections in patients with mild and moderate carpal tunnel syndrome. METHODS: In this randomized clinical trial, 78 patients with carpal tunnel syndrome were assigned to two groups...
February 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28229410/therapeutic-application-of-placental-mesenchymal-stem-cells-reprogrammed-neurospheres-in-spinal-cord-injury-of-scid
#7
Vikram Sabapathy, Franklin Jebaraj Herbert, Sanjay Kumar
Mesenchymal stromal cells (MSCs) and induced pluripotent stem cells (iPSCs) have stimulated much interest in the scientific community and hopes among the general public since their discovery in 1966 due to a variety of potential applications it has in the field of regenerative medicine. Copious amount of literature, as well as long-term animal and human clinical trials, indicates that MSCs can be successfully used for therapeutic purpose without any extreme adversities. MSCs have been isolated from adult and fetal tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229400/trans-synaptic-retrograde-degeneration-in-the-human-visual-system-slow-silent-and-real
#8
REVIEW
Marc Dinkin
Degeneration of neuron and axons following injury to cells with which they synapse is termed trans-synaptic degeneration. This phenomenon may be seen in postsynaptic neurons (anterograde) or in presynaptic neurons (retrograde). Retrograde trans-synaptic degeneration (RTSD) of the retinal ganglion cells and retinal nerve fiber layer following injury to the occipital lobe has been well documented histologically in animal studies, but its occurrence in the human retina was, for many years, felt to be limited to cases of neonatal injury during a critical period of neuronal development...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28229330/the-involvement-of-the-myelin-associated-inhibitors-and-their-receptors-in-cns-plasticity-and-injury
#9
REVIEW
Anthony G Boghdadi, Leon Teo, James A Bourne
The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair...
February 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28229327/two-years-after-injury-prevalence-and-early-post-injury-predictors-of-ongoing-injury-related-problems
#10
Suzanne J Wilson, Gabrielle Davie, Sarah Derrett
PURPOSE: To determine, in a cohort with injuries classified anatomically as mainly minor or moderate and for which only 25% were hospitalised acutely, the prevalence of ongoing problems attributed by participants to their injury 2 years prior, and to examine whether three-month post-injury experiences and expectations predict such problems. METHODS: Participants (N = 2231; 18-64 years at injury) were those in the Prospective Outcomes of Injury Study who completed the initial three-month and final two-year interviews...
February 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28228404/endothelial-colony-forming-cells-ameliorate-endothelial-dysfunction-via-secreted-factors-following-ischemia-reperfusion-injury
#11
Jason A Collett, Purvi Mehrotra, Allison Crone, W Christopher Shelley, Mervin C Yoder, David P Basile
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and in vivo vessel forming potential. We hypothesized that ECFCs may ameliorate the degree of AKI and/or promote repair of the renal vasculature following ischemia/reperfusion (I/R). Rat pulmonary microvascular ECs (PMVEC) with high proliferative potential were compared with pulmonary artery ECs (PAEC) with low proliferative potential in rats subjected to renal I/R...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28228109/fms-like-tyrosine-kinase-3-ligand-increases-resistance-to-burn-wound-infection-through-effects-on-plasmacytoid-dendritic-cells
#12
Leon Bae, Julia K Bohannon, Weihua Cui, Monika Vinish, Tracy Toliver-Kinsky
BACKGROUND: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. In a murine model of burn wound infection, the enhancement of DCs after injury by treatment with the DC growth factor Fms-like tyrosine kinase-3 ligand (FL) enhances neutrophil migration to infection, improves bacterial clearance, and increases survival in a DC-dependent manner...
February 22, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28228060/resuscitation-with-lyophilized-plasma-is-safe-and-improves-neurologic-recovery-in-a-long-term-survival-model-of-swine-subjected-to-traumatic-brain-injury-hemorrhagic-shock-and-polytrauma
#13
Patrick E Georgoff, Vahagn C Nikolian, Ihab Halaweish, Kiril Chtraklin, Peter J Bruhn, Hassan Eidy, Monica Rasmussen, Yongqing Li, Ashok Srinivasan, Hasan B Alam
We have previously shown that fresh frozen plasma (FFP) and lyophilized plasma decrease brain lesion size and improve neurologic recovery in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS). In this study, we examine whether these findings can be validated in a clinically relevant model of severe TBI, HS, and polytrauma. Female Yorkshire swine were subjected to TBI (controlled cortical impact), hemorrhage (40% volume), grade III liver and splenic injuries, rib fracture, and rectus abdominis crush...
February 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28227743/mri-measures-of-fat-infiltration-in-the-lower-extremities-following-motor-incomplete-spinal-cord-injury-reliability-and-potential-implications-for-muscle-activation
#14
Andrew C Smith, Maria Knikou, Katrina L Yelick, Abigail R Alexander, Margaret M Murnane, Andrew A Kritselis, Paul J Houmpavlis, Jacob G McPherson, Marie Wasielewski, Mark A Hoggarth, James M Elliott, Andrew C Smith, Maria Knikou, Katrina L Yelick, Abigail R Alexander, Margaret M Murnane, Andrew A Kritselis, Paul J Houmpavlis, Jacob G McPherson, Marie Wasielewski, Mark A Hoggarth, James M Elliott, Margaret M Murnane, Paul J Houmpavlis, Katrina L Yelick, Mark A Hoggarth, Marie Wasielewski, James M Elliott, Maria Knikou, Jacob G McPherson, Abigail R Alexander, Andrew A Kritselis, Andrew C Smith
Muscle fat infiltration (MFI) is an expected consequence of incomplete spinal cord injury (iSCI). The MFI magnitude may have clinical value in determining functional recovery. However, there is a lack of understanding of how MFI relates to the volitional muscle activity in people with motor incomplete spinal cord injury (iSCI). Five iSCI and 5 uninjured age-matched control subjects participated in the study. In this preliminary study, we established the reliability of MFI quantification of select lower extremity muscles across different raters...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227643/effect-of-environmental-factors-on-level-of-trip-disturbance-a-simulation-study
#15
Ming Liu, Peter Bohlen, He Helen Huang, Ming Liu, Peter Bohlen, He Helen Huang, Peter Bohlen, He Helen Huang, Ming Liu
Above knee amputees exhibit a higher risk of falling than able-bodied people, so the capacity to recover from trips (a major cause of unintentional falls) is critical for these amputees to prevent fall-related injuries. Although trip recovery approaches using powered prostheses have been proposed, the effectiveness of these approaches has not been evaluated with varied trip-related disturbance levels. Here, we conducted a simulation study to understand the relationship between trip-related disturbance levels and environmental factors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227554/cortical-excitability-effects-of-stimulation-intensity-change-speed-during-nmes
#16
Shenglong Jiang, Zhongpeng Wang, Weibo Yi, Feng He, Shuang Liu, Hongzhi Qi, Dong Ming, Shenglong Jiang, Zhongpeng Wang, Weibo Yi, Feng He, Shuang Liu, Hongzhi Qi, Dong Ming, Shuang Liu, Shenglong Jiang, Zhonapeng Wang, Dong Ming, Feng He, Qi Hongzhi, Weibo Yi
Rehabilitation method of motor dysfunction is a challenging issue of neural rehabilitation. Neuromuscular electrical stimulation (NMES) has been frequently used in rehabilitation therapy to improve neural recovery such as stroke and spinal cord injury. Stimulus, acting on sensorimotor neural system components, resulted in the increased cortical excitability which accompanied with motor performance improvement. Stimulus information conveyed by sensory system included below four elementary attributes: modality, location, intensity, and timing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227407/recursive-feature-elimination-for-biomarker-discovery-in-resting-state-functional-connectivity
#17
Hariharan Ravishankar, Radhika Madhavan, Rakesh Mullick, Teena Shetty, Luca Marinelli, Suresh E Joel, Hariharan Ravishankar, Radhika Madhavan, Rakesh Mullick, Teena Shetty, Luca Marinelli, Suresh E Joel, Suresh E Joel, Teena Shetty, Luca Marinelli, Rakesh Mullick, Hariharan Ravishankar, Radhika Madhavan
Biomarker discovery involves finding correlations between features and clinical symptoms to aid clinical decision. This task is especially difficult in resting state functional magnetic resonance imaging (rs-fMRI) data due to low SNR, high-dimensionality of images, inter-subject and intra-subject variability and small numbers of subjects compared to the number of derived features. Traditional univariate analysis suffers from the problem of multiple comparisons. Here, we adopt an alternative data-driven method for identifying population differences in functional connectivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227235/split-belt-controllable-treadmill-with-differential-velocity-based-fall-stimulation-and-motion-analysis
#18
Yasutaka Nakashima, Hiroki Noutsuka, Takanori Fukui, Motoji Yamamoto, Yasutaka Nakashima, Hiroki Noutsuka, Takanori Fukui, Motoji Yamamoto, Takanori Fukui, Hiroki Noutsuka, Yasutaka Nakashima, Motoji Yamamoto
Amid trends toward aging populations in developed nations, the number of people requiring nursing care has increased markedly. Slips and falls during ordinary daily activities are a common cause of fractured bones and muscle injury. Several studies have analyzed the movements produced by artificially generated slip and fall stimuli, but few have investigated these stimuli. We analyzed lower-limb motion following a slip and fall stimulus produced using a pulled free-walking system consisting of a controllable split-belt treadmill, where a speed difference between the belts could be applied to produce a slipping motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227095/a-small-portable-battery-powered-brain-computer-interface-system-for-motor-rehabilitation
#19
Colin M McCrimmon, Ming Wang, Lucas Silva Lopes, Po T Wang, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Colin M McCrimmon, Ming Wang, Lucas Silva Lopes, Po T Wang, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Ming Wang, An H Do, Zoran Nenadic, Colin M McCrimmon, Alireza Karimi-Bidhendi, Lucas Silva Lopes, Po T Wang, Charles Y Liu, Payam Heydari
Motor rehabilitation using brain-computer interface (BCI) systems may facilitate functional recovery in individuals after stroke or spinal cord injury. Nevertheless, these systems are typically ill-suited for widespread adoption due to their size, cost, and complexity. In this paper, a small, portable, and extremely cost-efficient (<;$200) BCI system has been developed using a custom electroencephalographic (EEG) amplifier array, and a commercial microcontroller and touchscreen. The system's performance was tested using a movement-related BCI task in 3 able-bodied subjects with minimal previous BCI experience...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226875/dihydrocapsaicin-induced-hypothermia-after-asphyxiai-cardiac-arrest-in-rats
#20
Junyun He, Leanne Young, Xiaofeng Jia, Junyun He, Leanne Young, Xiaofeng Jia, Xiaofeng Jia, Leanne Young, Junyun He
Cardiac arrest (CA) is one of the leading causes of mortality and morbidity in the world. Fast, reversible and controllable pharmaceutical-induced hypothermia (PIH) is strongly desired to treat ischemia-reperfusion brain injury. Dihydrocapsaicin (DHC), an agonist of transient receptor potential vanilloid type 1 cation channel (TRPV1), is an emerging candidate for PIH. Its capability to lower body temperature has been validated in both healthy and stroke animal models. However, DHC has shown cardiovascular effects and its safety and feasibility in a CA model has not been tested...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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