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https://www.readbyqxmd.com/read/29780110/bevacizumab-induced-aortic-arterial-thrombosis
#1
Kazuo Suzuki, Takahiro Yanagimura, Kazumasa Ohashi, Hiroshi Kagamu, Toshinori Takada
A 65-year-old man was diagnosed with advanced non-small, non-squamous lung cancer. He was treated with chemotherapy containing bevacizumab as well as cisplatin and pemetrexed. After 2 courses of treatment, computed tomography revealed that his abdominal aortic artery was almost occluded by a thrombus; however, he had no ischemic symptoms. Heparin infusion and warfarin reduced the size of the arterial thrombus and the patient was subsequently treated with chemotherapy without bevacizumab. No thrombotic events occurred during the subsequent treatment...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29768322/lung-cancer-screening-ct-based-coronary-artery-calcification-in-predicting-cardiovascular-events-a-systematic-review-and-meta-analysis
#2
Lili Fan, Kaikai Fan
BACKGROUND: Coronary artery calcificition (CAC) is a well-established predictor of cardiovascular events (CVEs). We aimed to evaluate whether lung cancer screening computed tomography (CT)-based CAC score has a good cost-effectiveness for predicting CVEs in heavy smokers. METHODS: A literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pubmed, EMBASE, and Cochrane library databases were systematically searched for relevant studies that investigated the association between lung cancer screening CT-based CAC and CVEs up to December 31, 2017...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29748003/frequency-and-distribution-of-incidental-findings-deemed-appropriate-for-s-modifier-designation-on-low-dose-ct-in-a-lung-cancer-screening-program
#3
Michael J Reiter, Allison Nemesure, Ezemonye Madu, Lisa Reagan, April Plank
PURPOSE: To describe the frequency, distribution and reporting patterns of incidental findings receiving the Lung-RADS S modifier on low-dose chest computed tomography (CT) among lung cancer screening participants. METHODS: This retrospective investigation included 581 individuals who received baseline low-dose chest CT for lung cancer screening between October 2013 and June 2017 at a single center. Incidental findings resulting in assignment of Lung-RADS S modifier were recorded as were incidental abnormalities detailed within the body of the radiology report only...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29741690/severe-multisystem-involvement-of-chronic-granulomatous-disease-in-a-pediatric-patient
#4
Zuhal Bayramoglu, Ibrahim Adaletli, Emine Caliskan, Manolya Acar, Selda Hancerli Torun, Ayper Somer
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder identified by recurrent pyogenic and fungal infections infections secondary to defective nicotinamide adenine dinucleotide phosphate oxidase enzyme. In the present study, we demonstrated a case with a history of multiple segmental lung resections because of invasive bronchopulmonary aspergillosis, multifocal hepatic and splenic granulomas, bilateral adnexal calcific foci presumed to be related with old granulomatous infection and finally gastric outlet obstruction secondary to the involvement of the stomach wall thickening with granulomatous tissue...
May 7, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29642833/-management-and-treatment-difficulties-of-multi-drug-resistant-pulmonary-tuberculosis-in-a-pediatric-case
#5
Selda Hançerli Törün, Emine Manolya Acar, Ayper Somer, Gonca Erköse, Dilek Şatana, Zuhal Bayramoğlu, Emine Çalışkan, Zeki Kılıçaslan
Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29608811/metastatic-pulmonary-calcification-experience-from-a-single-center-in-singapore
#6
Swee Ping Teh, Yuen Li Ng, Chau Ang Anthony Yii, Hui Lin Lina Choong, Jiunn Wong
Metastatic pulmonary calcification (MPC) was seen in 79% of patients with end-stage renal disease (ESRD) during autopsy. However, it is not commonly diagnosed in vivo. Its pathogenesis is not fully understood. We report a retrospective series of 5 cases of MPC from a single center in Singapore. MPC were diagnosed using radiological or histological features. Mean onset of MPC from diagnosis of ESRD was 22.6 ± 3.1 years. One patient remains asymptomatic. Four patients died, one was related to MPC. All patients had calcifications at the lung apices on radiological studies...
April 2, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29600734/inhalation-therapy-for-repairing-damaged-elastin-fibers-and-decelerating-elastinolysis-in-chronic-obstructive-pulmonary-disease
#7
Rob Janssen, Ianthe Piscaer, Emiel Fm Wouters
Current pharmacologic therapy of chronic obstructive pulmonary disease (COPD) can reduce respiratory symptoms and exacerbation frequency. However, no single COPD intervention except for lung transplantation has proven effective in recovering lung function. Lung elasticity is reduced in COPD lungs, which is for a large part due to chronically enhanced elastin degradation. Elastin calcification and formation of advanced glycation end products (AGEs) may also contribute to this. Areas covered: We propose inhalation therapy to induce repair of damaged pulmonary elastin fibers by stimulating tropoelastin synthesis, assembly and crosslinking in order to improve lung function in patients with COPD...
May 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29564321/prenatally-detected-thoracic-neuroblastoma
#8
Yejin Park, Hyun Jin Lee, Yun Ji Jung, Joon Ho Lee, Ja Young Kwon, Young-Han Kim
Neuroblastoma is the most common pediatric extracranial solid tumor derived from primitive neural crest cells of the sympathetic nervous system. Although one-fifths of all neuroblastomas occurs within the thorax, thoracic neuroblastomas detected in fetus have been rarely reported. We report a case of fetal thoracic neuroblastoma with massive pleural effusion detected with prenatal ultrasonography. A 34-year-old Korean second-gravida was referred to our hospital at 30 weeks of gestation for evaluation, after the right lung mass found in the fetus...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29563365/potential-asbestos-exposure-among-patients-with-primary-lung-cancer-in-japan
#9
Akihiko Tamura, Mitsuhiko Funakoshi, Naw Awn J-P, Kichinori Hasegawa, Atsushi Ishimine, Akio Koike, Noriyuki Tannai, Masami Fujii, Makoto Hattori, Harukazu Hirano, Kenji Nakamura, Masanobu Funakoshi, Kazuhiko Satomi, Yoshihito Yamashita, Yasuma Fukuchi, Narufumi Suganuma
OBJECTIVE: To investigate the extent of asbestos exposure among patients with primary lung cancer in Japan. METHODS: A retrospective estimation of potential asbestos-exposed individuals, as determined by the presence of pleural plaques identified on chest computed tomography (CT), was conducted on 885 pathologically confirmed primary lung cancer patients (mean age 71.3 years, 641 males). All patients were diagnosed at 29 hospitals across Japan between 2006 and 2007...
March 20, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29487246/computed-tomography-of-solitary-fibrous-tumor-of-the-pleura-abutting-the-mediastinum-a-diagnostic-challenge
#10
Luciano Cardinale, Giorgia Dalpiaz, Ilaria Pulzato, Francesco Ardissone
Background: Solitary fibrous tumor of the pleura (SFTP) arising from the mediastinal pleura may be confused with primary mediastinal tumors. We studied the computerized tomographic (CT) findings of patients with SFTP that could suggest a diagnosis of SFTP. Materials and Methods: At our hospital from January 1995 to June 2012, 39 patients with histologically confirmed SFTP were surgically treated; seven of them abutting the mediastinal pleura. The study group included seven patients aged between 53 and 81 years...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29486012/a-decision-tree-model-for-predicting-mediastinal-lymph-node-metastasis-in-non-small-cell-lung-cancer-with-f-18-fdg-pet-ct
#11
Kyoungjune Pak, Keunyoung Kim, Mi-Hyun Kim, Jung Seop Eom, Min Ki Lee, Jeong Su Cho, Yun Seong Kim, Bum Soo Kim, Seong Jang Kim, In Joo Kim
We aimed to develop a decision tree model to improve diagnostic performance of positron emission tomography/computed tomography (PET/CT) to detect metastatic lymph nodes (LN) in non-small cell lung cancer (NSCLC). 115 patients with NSCLC were included in this study. The training dataset included 66 patients. A decision tree model was developed with 9 variables, and validated with 49 patients: short and long diameters of LNs, ratio of short and long diameters, maximum standardized uptake value (SUVmax) of LN, mean hounsfield unit, ratio of LN SUVmax and ascending aorta SUVmax (LN/AA), and ratio of LN SUVmax and superior vena cava SUVmax...
2018: PloS One
https://www.readbyqxmd.com/read/29483527/the-influence-of-a-high-fat-diet-on-bone-and-soft-tissue-formation-in-matrix-gla-protein-knockout-mice
#12
S A Lanham, F R Cagampang, R O C Oreffo
Studies suggest bone growth and development are influenced by maternal nutrition, during intrauterine and early postnatal life. This study assessed the role of MGP and a maternal high fat diet on vitamin K-dependent proteins' gene expression and their impact on bone formation. Knockout (KO) offspring were smaller than wild type (WT) littermates, yet possessed the same volume of intrascapular brown adipose tissue. The total proportion of body fat was reduced, but only in animals on a control diet. Lung air volume was observed to be comparable in both KO and WT animals on the same diet...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29461888/some-unanticipated-consequences-of-early-cardiac-catheterization-insights-into-pulmonary-pathophysiology
#13
John B West
One of the most interesting unanticipated findings by André Cournand and Dickinson Richards in their groundbreaking studies of cardiac catheterization was the very low pressure in the normal pulmonary circulation. At the time, in the 1940s, the significance of this was not appreciated. For example, in their speeches at the Nobel Prize ceremony, neither of these laureates referred to the low pressure, although they did discuss other features of the pulmonary circulation. It was up to the cardiologist, William Dock, to point out that these low pressures implied a very uneven distribution of blood flow in the lung, and in particular that in the normal upright lung, the blood flow to the apex would be extremely small...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29459606/clinical-and-neuro-radiological-presentation-of-tuberous-sclerosis-complex-in-tertiary-care-centre
#14
G K Kundu, S Ahmed, S Akhter, M T Islam, T Dwa, A M Sabbir
Tuberous sclerosis complex (TSC) is a common neurocutaneous disorder characterized by hamartomatous changes in the lungs, brain, kidneys, skin, heart, and other organs. This retrospective study was done to see the clinical presentation and neuro imaging pattern of TSC in a tertiary care centre of Bangladesh and was conducted at Pediatric Neurology Unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2013 to December 2013. Among total 10 patients male-female ratio was 3:2...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29457229/radiomics-analysis-of-pulmonary-nodules-in-low-dose-ct-for-early-detection-of-lung-cancer
#15
Wookjin Choi, Jung Hun Oh, Sadegh Riyahi, Chia-Ju Liu, Feng Jiang, Wengen Chen, Charles White, Andreas Rimner, James G Mechalakos, Joseph O Deasy, Wei Lu
PURPOSE: To develop a radiomics prediction model to improve pulmonary nodule (PN) classification in low-dose CT. To compare the model with the American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) for early detection of lung cancer. METHODS: We examined a set of 72 PNs (31 benign and 41 malignant) from the Lung Image Database Consortium image collection (LIDC-IDRI). One hundred three CT radiomic features were extracted from each PN...
April 2018: Medical Physics
https://www.readbyqxmd.com/read/29434948/granulocyte-colony-stimulating-factor-producing-mucinous-cystic-neoplasm-with-an-associated-invasive-carcinoma-of-the-pancreas
#16
Kazuhide Shimamatsu, Yoshiki Naito, Yutaro Mihara, Masamichi Nakayama, Masahiko Tanigawa, Yushi Abe, Ken Nakamura, Toshihiro Araki, Kenji Sakata, Kazunori Noguchi, Jun Akiba, Hirohisa Yano, Osamu Nakashima
The present case study documents an autopsy case of granulocyte-colony stimulating factor (G-CSF)-producing mucinous cystic neoplasm (MCN), with an associated invasive carcinoma of the pancreas. A 65-year-old woman presented to Omuta City Hospital (Omuta Japan) with a primary complaint of abdominal pain. Multiple liver nodules and a pancreatic cyst were detected upon abdominal computed tomography. Initially, liver abscess was suspected as the patient exhibited leukocytosis and elevated C-reactive protein level...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432063/approach-to-pulmonary-hypertension-from-ct-to-clinical-diagnosis
#17
Felipe Aluja Jaramillo, Fernando R Gutierrez, Federico G Díaz Telli, Sebastian Yevenes Aravena, Cylen Javidan-Nejad, Sanjeev Bhalla
Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary circulation. It may be idiopathic or arise in the setting of other clinical conditions. Patients with PH tend to present with nonspecific cardiovascular or respiratory symptoms. The clinical classification of PH was recently revised at the World Health Organization symposium in Nice, France, in 2013. That consensus statement provided an updated classification based on the shared hemodynamic characteristics and management of the different categories of PH...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29408789/automatic-calcium-scoring-in-low-dose-chest-ct-using-deep-neural-networks-with-dilated-convolutions
#18
Nikolas Lessmann, Bram van Ginneken, Majd Zreik, Pim A de Jong, Bob D de Vos, Max A Viergever, Ivana Isgum
Heavy smokers undergoing screening with low-dose chest CT are affected by cardiovascular disease as much as by lung cancer. Low-dose chest CT scans acquired in screening enable quantification of atherosclerotic calcifications and thus enable identification of subjects at increased cardiovascular risk. This paper presents a method for automatic detection of coronary artery, thoracic aorta, and cardiac valve calcifications in low-dose chest CT using two consecutive convolutional neural networks. The first network identifies and labels potential calcifications according to their anatomical location and the second network identifies true calcifications among the detected candidates...
February 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29383526/leveraging-the-coronary-calcium-scan-beyond-the-coronary-calcium-score
#19
REVIEW
Daniel Bos, Maarten J G Leening
Non-contrast cardiac computed tomography in order to obtain the coronary artery calcium score has become an established diagnostic procedure in the clinical setting, and is commonly employed in clinical and population-based research. This state-of-the-art review paper highlights the potential gain in information that can be obtained from the non-contrast coronary calcium scans without any necessary modifications to the scan protocol. This includes markers of cardio-metabolic health, such as the amount of epicardial fat and liver fat, but also markers of general health including bone density and lung density...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29375904/chest-wall-a-structure-underestimated-in-ultrasonography-part-iii-neoplastic-lesions
#20
REVIEW
Andrzej Smereczyński, Katarzyna Kołaczyk, Elżbieta Bernatowicz
Chest wall neoplasms mainly include malignancies, metastatic in particular. Differential diagnosis should include clinical data; tumor location, extent, delineation; the degree of homogeneity; the presence of calcifications; the nature of bone destruction and the degree of vascularization. The aim of the paper is to present both the benefits and limitations of ultrasound for the diagnosis of chest wall neoplasms. The neoplastic process may be limited to the chest wall; it may spread from the chest wall into the intrathoracic structures or spread from the inside of the chest towards the chest wall...
December 2017: Journal of Ultrasonography
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