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https://www.readbyqxmd.com/read/29166387/effects-of-total-sleep-deprivation-on-divided-attention-performance
#1
Eric Chern-Pin Chua, Eric Fang, Joshua J Gooley
Dividing attention across two tasks performed simultaneously usually results in impaired performance on one or both tasks. Most studies have found no difference in the dual-task cost of dividing attention in rested and sleep-deprived states. We hypothesized that, for a divided attention task that is highly cognitively-demanding, performance would show greater impairment during exposure to sleep deprivation. A group of 30 healthy males aged 21-30 years was exposed to 40 h of continuous wakefulness in a laboratory setting...
2017: PloS One
https://www.readbyqxmd.com/read/29162717/reference-values-for-the-6-min-walk-distance-6mwt-in-healthy-children-aged-7-to-12-years-in-brazil-main-results-of-the-tc6minbrasil-multi-center-study
#2
Lucas de Assis Pereira Cacau, Vitor Oliveira Carvalho, Alessandro Dos Santos Pin, Carlos Raphael Araujo Daniel, Daisy Satomi Ykeda, Eliane Maria de Carvalho, Juliana Valente Francica, Luíza Martins Faria, Mansueto Gomes-Neto, Marcelo Fernandes, Marcelo Velloso, Marlus Karsten, Patrícia de Sá Barros, Valter Joviniano de Santana-Filho
INTRODUCTION: Brazil is a country with great climatic, socioeconomic, and cultural differences that does not yet have a reference value for the 6-min walk test (6MWT) in healthy children. To avoid misinterpretation, the use of equations to predict the maximum walking distance should be established in each country. OBJECTIVES: We sought to establish reference values and to develop an equation to predict the 6-min walk distance (6MWT) for healthy children in Brazil...
November 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29162543/identification-expression-analysis-and-antibacterial-activity-of-nk-lysin-from-common-carp-cyprinus-carpio
#3
Gai Ling Wang, Ming Cheng Wang, Ying Li Liu, Qian Zhang, Chuan Feng Li, Pan Ting Liu, En Zhong Li, Pin Nie, Hai Xia Xie
Natural killer lysin (NK-lysin), produced by cytotoxic T lymphocytes and natural killer cells, is a cationic antimicrobial peptide that has a broad antimicrobial spectrum, including bacteria, viruses, and parasites. Nevertheless, the implication of NK-lysin in the protection against bacterial infection is not aware in common carp. In this study, six different NK-lysin genes (nkl1, nkl2, nkl3, nkl4, nkl5 and nkl6) were identified in the common carp genome. Each of the mature peptides of common carp NK-lysin has six well-conserved cysteine residues, and shares a Saposin B domain, characteristic of saposin-like protein (SALIP) family...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29162445/the-neuromorphological-caudate-putaminal-clustering-of-neostriate-interneurons-kohonen-self-organizing-maps-and-supervised-artificial-neural-networks-with-multivariate-analysis
#4
Ivan Grbatinić, Nebojša Milošević, Bojana Krstonošić
AIMS: The objective of this study is to investigate the possibility of the neuromorphotopological clustering of neostriate interneurons (NSIN) and their consequent classification into caudate (CIN) and putaminal neuron type (PIN), according to the nuclear localization of the neurons. It tends to discover whether these two topological neuron types are morphologically different. MATERIAL AND METHODS: The binary images of adult human NSIN are used for the purposes of the analysis...
November 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29162245/ultrasound-guided-supra-acetabular-pin-placement-in-pelvic-external-fixation-description-of-a-surgical-technique-and-results
#5
Francisco Chana-Rodríguez, Manuel Cuervas-Mons, José Rojo-Manaute, Félix Mora, Juan Arnal, Javier Vaquero-Martín
INTRODUCTION: Pelvic fracture in trauma patients can lead to hemodynamic instability. External fixation is a treatment capable of stabilizing these injuries in the context of damage control surgery. Supra-acetabular pin offers the greater biomechanical stability but requires the use of intraoperative fluoroscopy. The aim of this study was to analyze our results for an ultrasound-guided supra-acetabular pinning. MATERIAL AND METHODS: Cross-sectional study with cadaveric specimens...
November 2017: Injury
https://www.readbyqxmd.com/read/29162108/reduced-suppressive-effect-of-%C3%AE-2-adrenoceptor-agonist-on-fibrocyte-function-in-severe-asthma
#6
Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
BACKGROUND: Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β2-AR agonists, alone or in combination with corticosteroids, on fibrocyte function. METHODS: Non-adherent non-T cells from peripheral blood mononuclear cells isolated from healthy subjects and patients with non-severe or severe asthma were treated with the β2-AR agonist, salmeterol, in the presence or absence of the corticosteroid dexamethasone...
November 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29160725/management-of-neurologic-deformity-of-the-ankle-and-foot-with-concurrent-osteomyelitis-with-the-ilizarov-method
#7
Nikolay Mikhailovich Kliushin, Anatoliy Sergeyevich Sudnitsyn, Koushik Narayan Subramanyam, Jefferson George
BACKGROUND: The combination of neurologic deformity of the ankle and foot with osteomyelitis is a therapeutic challenge. We investigated the role of Ilizarov with regard to eradication of infection, correction of deformities and improvement of patient function. METHODS: We retrospectively reviewed 77 patients (77 feet) with neurologic deformity of the ankle and foot with osteomyelitis treated sequentially in 3 stages by Ilizarov method. The 3 stages were (1) active debridement and Ilizarov stabilization, (2) further strengthening of Ilizarov fixator and active osteosynthesis consisting of strategies like arthrodesis, osteotomy distraction, bone transport, or combination thereof, (3) consolidation of fusion/regeneration achieved in second stage...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29160723/automation-of-a-dosing-disc-capsule-filler-from-the-perspective-of-reliability-and-safety
#8
Bernhard Wagner, Thomas Brinz, Stephanie Otterbach, Johannes Khinast
The aim of this paper is to explore the possibility to develop an automatically adjustable, reliable and safe capsule filling operation. Process parameters that are critical for the tamping pin process were reviewed based on the literature and via experiment. Dosing disc height, powder bed height, machine speed, pressure on the tamping pin and immersion depth were reviewed. Two investigations were performed on a GKF 702. In the first one, the powder feed rate onto the dosing disc was examined and modified. A distance sensor with a PID controller enabled a constant powder bed level with an online changeable set point...
November 21, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29160138/a-case-of-dedifferentiated-chondrosarcoma-arising-in-the-cricoid-cartilage-that-mimicked-an-aneurysmal-bone-cyst
#9
Lixiao Chen, Ziwei Yu, Rui Jiang, Pin Dong, Bin Shen, Yu Li
Dedifferentiated chondrosarcoma of the larynx is a rare and highly malignant tumor. We present the report of a 59-year-old man with dedifferentiated laryngeal chondrosarcoma, which was difficult to diagnose even under microscopic examination. The original diagnosis was an aneurysmal bone cyst, and the final diagnosis was established only after careful consideration of the imaging, surgical, and microscopic findings. In clinical practice, there are many similarities between dedifferentiated chondrosarcoma and aneurysmal bone cysts...
November 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29159972/vitamin-b12-deficiency-and-impaired-expression-of-amnionless-during-aging
#10
Alice Pannérec, Eugenia Migliavacca, Antonio De Castro, Joris Michaud, Sonia Karaz, Laurence Goulet, Serge Rezzi, Tze Pin Ng, Nabil Bosco, Anis Larbi, Jerome N Feige
BACKGROUND: Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitamin B12 deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether aging and frailty associate with altered vitamin B12 homeostasis in humans and investigated the underlying molecular mechanisms using preclinical models...
November 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29159851/comparison-of-three-fixation-methods-in-treatment-of-tibial-fracture-in-adolescents
#11
REVIEW
Lixiang Lin, Yang Liu, Chuanlu Lin, Yifei Zhou, Yongzeng Feng, Xiaolong Shui, Kehe Yu, Xiaolang Lu, Jianjun Hong, Yang Yu
BACKGROUND: Tibial fractures are the most common musculoskeletal injury in adolescents. The optimal management of tibial fractures in adolescents is controversial. In this study, we compared the outcomes including complications of three fixation methods in tibial fractures of adolescents and explored the factors associated with the complications. METHODS: A retrospective cohort study about 83 diaphyseal tibial fractures in 79 children and adolescents, who were treated with plate fixation (PF), elastic stable intramedullary nail fixation (ESINF), or external fixation (EF), was conducted...
November 21, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29159265/characterizing-biomarker-features-of-cognitively-normal-individuals-with-ventriculomegaly
#12
Xiaofeng Li, Maowen Ba, Kok Pin Ng, Sulantha Mathotaarachchi, Tharick A Pascoal, Pedro Rosa-Neto, Serge Gauthier
Introduction: The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods: We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29158645/evaluation-of-functional-outcome-of-pilon-fractures-managed-with-limited-internal-fixation-and-external-fixation-a-prospective-clinical-study
#13
Umesh Kumar Meena, Mahesh Chand Bansal, Prateek Behera, Rahul Upadhyay, Gyan Chand Gothwal
Introduction: The management of pilon fractures is controversial primarily due to the high rate of complications irrespective of the mode of treatment. Limited internal fixation with external fixation is associated with minimal soft tissue handling. This may reduce the chances of wound dehiscence and infection. This study was designed to evaluate the functional and clinical outcomes in patients treated with limited internal fixation combined with external fixation in pilon fractures. Material and methods: This study was conducted as a prospective clinical study on 56 skeletally mature patients with closed fractures with poor skin condition, and with open grade 1 and grade 2 distal tibial intra-articular fractures...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29158549/hypoxia-inducible-factor-1%C3%AE-mediates-the-profibrotic-effect-of-albumin-in-renal-tubular-cells
#14
Junping Hu, Weili Wang, Fan Zhang, Pin-Lan Li, Krishna M Boini, Fan Yi, Ningjun Li
Proteinuria is closely associated with the progression of chronic kidney diseases (CKD) by producing renal tubulointerstitial fibrosis. Over-activation of hypoxia inducible factor (HIF)-1α has been implicated in the progression of CKD. The present study tested the hypothesis that HIF-1α mediates albumin-induced profibrotic effect in cultured renal proximal tubular cells. Incubation of the cells with albumin (40 μg/ml) for 72 hrs significantly increased the protein levels of HIF-1α, tissue inhibitor of metalloproteinase (TIMP)-1 and collagen-I, which were blocked by HIF-1α shRNA...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158057/the-wnt-%C3%AE-catenin-pathway-contributes-to-the-regulation-of-adipocyte-development-induced-by-docosahexaenoic-acid-in-grass-carp-ctenopharyngodon-idellus
#15
Pin Liu, Jing-Jing Tian, Hong Ji, Jian Sun, Chao Li, Ji-Qin Huang, Yang Li, Hai-Bo Yu, Er-Meng Yu, Jun Xie
Docosahexaenoic acid (DHA) has been suggested to inhibit adipogenesis in fish; the mechanism behind this observation remains largely unknown. The present study was to investigate the effects of DHA on the adipocyte differentiation of grass carp by using transcriptomic technology. Confluent primary cultured differentiating adipocytes were co-incubated with either 0μM or 100μM DHA for 2days (early phase of differentiation) and 7days (late phase). The results showed that 100μM DHA promoted adipogenesis at 2days but decreased lipid accumulation at 7days of treatment compared to that of the control...
November 17, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29157991/percutaneous-k-wire-fixation-in-pediatric-lateral-condylar-fractures-of-humerus-a-prospective-study
#16
Ramji Lal Sahu
BACKGROUND: We evaluated the radiographic and clinical functional results of K-wire fixation in the treatment of displaced lateral condyle fractures of the humerus. MATERIALS AND METHODS: A prospective longitudinal study was undertaken in our hospital during the period December 2010-December 2014. A total number of 85 children (18 girls and 67 boys) mean age 7.76 years; range 2-13 years with displaced (>2mm) lateral condyle fractures of the humerus. All the patients were treated by close reduction and internal fixation with two K-wires for three weeks...
November 17, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29157841/acute-management-of-high-energy-lisfranc-injuries-a-simple-approach
#17
Dolfi Herscovici, Julia M Scaduto
INTRODUCTION: The aims of this study were to (1) describe the use of the K-wire for the initial management of high-energy Lisfranc dislocations or fracture dislocations, (2) to evaluate whether this standalone technique allowed for adequate reduction of these injuries, (3) to evaluate whether reductions were maintained until definitive fixation was performed, (4) and to determine if it contributed to any increase in complications prior to or after definitive fixation. PATIENTS AND METHODS: A retrospective review was performed on all patients who presented with tarsometatarsal injuries from January 2005 through June 2015...
November 16, 2017: Injury
https://www.readbyqxmd.com/read/29156742/prmda-personalized-recommendation-based-mirna-disease-association-prediction
#18
Zhu-Hong You, Luo-Pin Wang, Xing Chen, Shanwen Zhang, Xiao-Fang Li, Gui-Ying Yan, Zheng-Wei Li
Recently, researchers have been increasingly focusing on microRNAs (miRNAs) with accumulating evidence indicating that miRNAs serve as a vital role in various biological processes and dysfunctions of miRNAs are closely related with human complex diseases. Predicting potential associations between miRNAs and diseases is attached considerable significance in the domains of biology, medicine, and bioinformatics. In this study, we developed a computational model of Personalized Recommendation-based MiRNA-Disease Association prediction (PRMDA) to predict potential related miRNA for all diseases by implementing personalized recommendation-based algorithm based on integrated similarity for diseases and miRNAs...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156632/neurotropism-in-vitro-and-mouse-models-of-severe-and-mild-infection-with-clinical-strains-of-enterovirus-71
#19
Pin Yu, Linlin Bao, Lili Xu, Fengdi Li, Qi Lv, Wei Deng, Yanfeng Xu, Chuan Qin
Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild EV71 infection are lacking. The aim of the study was to investigate the neurovirulence of EV71 strains and the differences in serum cytokine and chemokine levels in mouse models of severe and mild EV71 infection. Nine EV71 isolates belonging to the C4 subgenogroup (proposed as genotype D) displayed infectivity in human neuroblastoma SK-N-SH cells; moreover, ultrastructural observation confirmed viral particle replication...
November 20, 2017: Viruses
https://www.readbyqxmd.com/read/29156167/advancements-in-bone-fixation-utilizing-novel-biointegrative-fixation-technology
#20
REVIEW
Bob Baravarian, Tal Pnina Lindner, Ronit Merchav-Feuermann
Advancement in orthopedics have been increasing rapidly. The most important advances have been in fixation. With time, metallic hardware will begin to be replaced by materials that become one with the body. This progress will not only aid in the repair process it will allow permanent and improved reinforcement of the fixated region. Biointegrative technology is a promising new generation of materials capable of achieving this goal. Over time, it is expected that plates, screws, pins, interference screws, and even possibly joint replacements will incorporate into patients' bodies, negating the need for hardware removal and adding structure and stability to an iatrogenically weakened area...
January 2018: Clinics in Podiatric Medicine and Surgery
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