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https://www.readbyqxmd.com/read/29352975/pinocembrin-from-penthorum-chinense-pursh-suppresses-hepatic-stellate-cells-activation-through-a-unified-sirt3-tgf-%C3%AE-smad-signaling-pathway
#1
Fayang Zhou, Anqi Wang, Dan Li, Yitao Wang, Ligen Lin
The inactivation of hepatic stellate cells (HSCs) has been verified to be an effective therapeutic strategy for treatment of liver fibrosis. Penthorum chinense Pursh has been widely used to protect liver in China; while, the role of P. chinense Pursh in treatment of liver fibrosis is still unexplored. In the current study, the aqueous extract of P. chinense Pursh (PCE) was found to suppress the expressions of fibrotic markers, including collagen I and α-smooth muscle actin (α-SMA), in human HSCs (LX-2); and its major active constituent, pinocembrin (PIN), was discovered to inhibit the expressions of fibrotic markers in LX-2 cells and rat HSCs (HSC-T6)...
January 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29352689/morbidity-and-safety-of-iliac-crest-reference-array-pins-in-navigated-total-hip-arthroplasty-a-prospective-cohort-study
#2
Anton P Lambers, Xiang G Salim, Robert Jennings, Andrew T Bucknill
BACKGROUND: Navigated total hip arthroplasty (THA) can employ intra-osseous pins through a separate incision to secure reference arrays to the iliac crest. This study is the first to investigate the consequences of pin use in THA in vivo. METHODS: A prospective, consecutive series of 43 patients presenting for navigated THA were included. Two temporary 125 × 4 mm Schanz screws were inserted into the iliac crest for the attachment of a reference array. Telephone follow-up occurred at 6 and 12 weeks post-operatively...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352436/posterolateral-tibial-plateau-fractures-how-to-buttress-reversed-l-posteromedial-or-the-posterolateral-approach-a-comparative-cadaveric-study
#3
Wich Orapiriyakul, Theerachai Apivatthakakul, Chanakarn Phornphutkul
INTRODUCTION: The selection of a surgical approach for buttressing posterolateral tibial plateau fractures is controversial. OBJECTIVE: This study compared the surgical exposure area between the reversed L posteromedial approach (R-PM) and the posterolateral (PL) approach using the lateral plateau width as a metric. MATERIALS AND METHODS: Twenty lower extremities from fresh frozen cadavers were included. The R-PM approach was used first and the boundary of the posterior tibial cortex exposure was marked with metal pins...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352144/pressure-assisted-enhancement-in-superconducting-properties-of-fe-substituted-nbse2-single-crystal
#4
Manikandan Krishnan, Rukshana Pervin, Kalai Selvan Ganesan, Kannan Murugesan, Govindaraj Lingannan, Akshay Kumar Verma, Parasharam M Shirage, Arumugam Sonachalam
The impact of hydrostatic pressure (P) up to 1 GPa on T c , J c and the nature of the pinning mechanism in FexNbSe2 single crystals have been investigated within the framework of the collective theory. We found that the pressure can induce a transition from the regime where pinning is controlled by spatial variation in the critical transition temperature (δT c ) to the regime controlled by spatial variation in the mean free path (δℓ). Furthermore, T c and low field J c are slightly induced, although the J c drops more rapidly at high fields than at ambient P...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29350774/hepatitis-b-virus-surface-gene-pre-s2-mutant-as-a-high-risk-serum-marker-for-hepatoma-recurrence-after-curative-hepatic-resection
#5
Chia-Jui Yen, Yu-Lin Ai, Hung-Wen Tsai, Shih-Huang Chan, Chia-Sheng Yen, Kuang-Hsiung Cheng, Yun-Ping Lee, Chia-Wei Kao, Yu-Chun Wang, Yi-Lin Chen, Cheng-Han Lin, Tsunglin Liu, Huey-Pin Tsai, Jen-Ren Wang, Ih-Jen Su, Wenya Huang
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S2 mutant large HBV surface antigen (LHBS) is highly associated with HCC. This study aimed to analyze the expression of the large form of surface protein in tumors and to evaluate the LHBS with mutations within the pre-S2 region as a high-risk recurrence marker in HCC patients after curative hepatic resection. By the analyses of immunohistochemical staining (N = 12) and Western Blotting (N = 22), the HBV surface protein, which is mainly comprised of the major form of HBS, was greatly diminished in the tumors...
January 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29350233/stacking-faults-in-zr-fe-cr-2-laves-structured-secondary-phase-particle-in-zircaloy-4-alloy
#6
Chengze Liu, Geping Li, Fusen Yuan, Fuzhou Han, Yingdong Zhang, Hengfei Gu
Stacking faults (SFs) in secondary phase particles (SPPs), which generally crystallize in the Laves phase in Zircaloy-4 (Zr-4) alloy, have been frequently observed by researchers. However, few investigations on the nano-scale structure of SFs have been carried out. In the present study, an SF containing C14 structured SPP, which located at grain boundaries (GBs) in the α-Zr matrix, was chosen to be investigated, for its particular substructure as well as location, aiming to reveal the nature of the SFs in the SPPs in Zr-4 alloy...
January 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29348394/hoxc6-predicts-invasion-and-poor-survival-in-hepatocellular-carcinoma-by-driving-epithelial-mesenchymal-transition
#7
Pin-Dong Li, Peng Chen, Xin Peng, Charlie Ma, Wen-Jie Zhang, Xiao-Fang Dai
Aberrant expression of HOXC6 has been reported in several malignant tumors, yet little is known about the value of HOXC6 in invasion and prognosis of hepatocellular carcinoma (HCC). HOXC6 expression was positively correlated with high AFP level, liver cirrhosis, larger tumor, vascular invasion and BCLC stage. Kaplan-Meier analysis revealed that HOXC6 was an independent predictor for overall survival (OS) and time to recurrence (TTR). In addition, HOXC6 status could act as prognostic predictor in different risk subgroups...
January 15, 2018: Aging
https://www.readbyqxmd.com/read/29347746/topological-defects-in-two-dimensional-orientation-field-models-for-grain-growth
#8
Bálint Korbuly, Mathis Plapp, Hervé Henry, James A Warren, László Gránásy, Tamás Pusztai
Standard two-dimensional orientation-field-based phase-field models rely on a continuous scalar field to represent crystallographic orientation. The corresponding order parameter space is the unit circle, which is not simply connected. This topological property has important consequences for the resulting multigrain structures: (i) trijunctions may be singular; (ii) for each pair of grains there exist two different grain boundary solutions that cannot continuously transform to one another; (iii) if both solutions appear along a grain boundary, a topologically stable, singular point defect must exist between them...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347514/pinning-of-a-drop-by-a-junction-on-an-incline
#9
Joël De Coninck, Juan Carlos Fernández Toledano, François Dunlop, Thierry Huillet
The shape of a drop pinned on an inclined substrate is a long-standing problem where the complexity of real surfaces, with heterogeneities and hysteresis, makes it complicated to understand the mechanisms behind the phenomena. Here we consider the simple case of a drop pinned on an incline at the junction between a hydrophilic half plane (the top half) and a hydrophobic one (the bottom half). Relying on the equilibrium equations deriving from the balance of forces, we exhibit three scenarios depending on the way the contact line of the drop on the substrate either simply leans against the junction or overfills (partly or fully) into the hydrophobic side...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347457/pinning-and-unbinding-of-ideal-polymers-from-a-wedge-corner
#10
Raz Halifa Levi, Yacov Kantor, Mehran Kardar
A polymer repelled by unfavorable interactions with a uniform flat surface may still be pinned to attractive edges and corners. This is demonstrated by considering adsorption of a two-dimensional ideal polymer to an attractive corner of a repulsive wedge. The well-known mapping between the statistical mechanics of an ideal polymer and the quantum problem of a particle in a potential is then used to analyze the singular behavior of the unbinding transition of the polymer. The divergence of the localization length is found to be governed by an exponent that varies continuously with the angle (when reflex)...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347436/quantification-of-tension-to-explain-bias-dependence-of-driven-polymer-translocation-dynamics
#11
P M Suhonen, J Piili, R P Linna
Motivated by identifying the origin of the bias dependence of tension propagation, we investigate methods for measuring tension propagation quantitatively in computer simulations of driven polymer translocation. Here, the motion of flexible polymer chains through a narrow pore is simulated using Langevin dynamics. We measure tension forces, bead velocities, bead distances, and bond angles along the polymer at all stages of translocation with unprecedented precision. Measurements are done at a standard temperature used in simulations and at zero temperature to pin down the effect of fluctuations...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347352/simple-scaling-laws-for-the-evaporation-of-droplets-pinned-on-pillars-transfer-rate-and-diffusion-limited-regimes
#12
Ruth Hernandez-Perez, José L García-Cordero, Juan V Escobar
The evaporation of droplets can give rise to a wide range of interesting phenomena in which the dynamics of the evaporation are crucial. In this work, we find simple scaling laws for the evaporation dynamics of axisymmetric droplets pinned on millimeter-sized pillars. Different laws are found depending on whether evaporation is limited by the diffusion of vapor molecules or by the transfer rate across the liquid-vapor interface. For the diffusion-limited regime, we find that a mass-loss rate equal to 3/7 of that of a free-standing evaporating droplet brings a good balance between simplicity and physical correctness...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347292/boundary-conditions-for-a-one-sided-numerical-model-of-evaporative-instabilities-in-sessile-drops-of-ethanol-on-heated-substrates
#13
Sergey Semenov, Florian Carle, Marc Medale, David Brutin
The work is focused on obtaining boundary conditions for a one-sided numerical model of thermoconvective instabilities in evaporating pinned sessile droplets of ethanol on heated substrates. In the one-sided model, appropriate boundary conditions for heat and mass transfer equations are required at the droplet surface. Such boundary conditions are obtained in the present work based on a derived semiempirical theoretical formula for the total droplet's evaporation rate, and on a two-parametric nonisothermal approximation of the local evaporation flux...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347134/dynamics-of-scroll-waves-in-a-cylinder-jacket-geometry
#14
Christian Bruns, Marcus J B Hauser
The dynamics of scroll waves in a narrow cylinder jacket-shaped reactor is investigated experimentally by optical tomography. The fate of the scroll waves of excitation in the Belousov-Zhabotinsky reaction depends on the thickness of the cylinder jacket. While at sufficiently wide cylinder jackets vertically oriented scroll waves remain stable, the probability that the filament of a scroll hits a lateral wall increases as the cylinder jacket narrows. This may lead to the rupture of the initial filament and pinning of the filament ends at the lateral walls...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347108/in-silico-optimization-of-critical-currents-in-superconductors
#15
Gregory Kimmel, Ivan A Sadovskyy, Andreas Glatz
For many technological applications of superconductors the performance of a material is determined by the highest current it can carry losslessly-the critical current. In turn, the critical current can be controlled by adding nonsuperconducting defects in the superconductor matrix. Here we report on systematic comparison of different local and global optimization strategies to predict optimal structures of pinning centers leading to the highest possible critical currents. We demonstrate performance of these methods for a superconductor with randomly placed spherical, elliptical, and columnar defects...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345710/small-degree-of-anisotropic-wetting-on-self-similar-hierarchical-wrinkled-surfaces
#16
Gaojian Lin, Qiuting Zhang, Cunjing Lv, Yichao Tang, Jie Yin
We studied the wetting behavior of multiscale self-similar hierarchical wrinkled surfaces. The hierarchical surface was fabricated on poly(dimethylsiloxane) (PDMS) substrates by manipulating the sequential strain release and combined plasma/ultraviolet ozone (UVO) treatment. The generated structured surface shows an independently controlled dual-scale roughness with level-1 small-wavelength wrinkles (wavelength of 700-1500 nm and amplitude of 50-500 nm) resting on level-2 large-wavelength wrinkles (wavelength of 15-35 μm and amplitude of 3...
January 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29343943/the-oral-bioavailability-excretion-and-cytochrome-p450-inhibition-properties-of-epiberberine-an-in-vivo-and-in-vitro-evaluation
#17
Ning Chen, Xiao-Yan Yang, Chang-E Guo, Xin-Ning Bi, Jian-Hua Chen, Hong-Ying Chen, Hong-Pin Li, Hong-Ying Lin, Yu-Jie Zhang
Epiberberine (EPI) is a novel and potentially effective therapeutic and preventive agent for diabetes and cardiovascular disease. To evaluate its potential value for drug development, a specific, sensitive and robust high-performance liquid chromatography-tandem mass spectrometry assay for the determination of EPI in rat biological samples was established. This assay was used to study the pharmacokinetics, bioavailability and excretion of EPI in rats after oral administration. In addition, a cocktail method was used to compare the inhibition characteristics of EPI on cytochrome P450 (CYP450) isoforms in human liver microsomes (HLMs) and rat liver microsomes (RLMs)...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29343852/a-new-class-of-magnetically-actuated-pumps-and-valves-for-microfluidic-applications
#18
Joshua K Hamilton, Matthew T Bryan, Andrew D Gilbert, Feodor Y Ogrin, Thomas O Myers
We propose a new class of magnetically actuated pumps and valves that could be incorporated into microfluidic chips with no further external connections. The idea is to repurpose ferromagnetic low Reynolds number swimmers as devices capable of generating fluid flow, by restricting the swimmers' translational degrees of freedom. We experimentally investigate the flow structure generated by a pinned swimmer in different scenarios, such as unrestricted flow around it as well as flow generated in straight, cross-shaped, Y-shaped and circular channels...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343155/carboxymethyl-chitosan-zinc-coating-for-prevention-of-pin-tract-infection-an-animal-model
#19
Vidmi Taolam Martin, Lei Wang, Rong Zeng, DeQiang You, XianRong Zhang, Welera Haissou Elodie, Bin Yu
BACKGROUND: Pin tract infection is a common problem in orthopedic and traumatology surgery. The aim of this study was to investigate the efficacy of an implant coated with carboxymethyl chitosan-zinc (CMC-Zn2+) in prevention of pin tract infection. MATERIALS AND METHODS: Twenty-four male New Zealand White rabbits were randomized into two equal groups ( n = 12, uncoated and CMC-Zn2+). The implants were colonized with 1 × 106 colony forming units of Staphylococcus aureus and inserted into the lateral right proximal tibia in each rabbit...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29342110/medlay-a-reconfigurable-micro-power-management-to-investigate-self-powered-systems
#20
Jan Kokert, Tobias Beckedahl, Leonhard M Reindl
In self-powered microsystems, a power management is essential to extract, transfer and regulate power from energy harvesting sources to loads such as sensors. The challenge is to consider all of the different structures and components available and build the optimal power management on a microscale. The purpose of this paper is to streamline the design process by creating a novel reconfigurable testbed called Medlay. First, we propose a uniform interface for management functions e.g., power conversion, energy storing and power routing...
January 17, 2018: Sensors
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