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https://www.readbyqxmd.com/read/27427904/xrp44x-an-inhibitor-of-ras-erk-activation-of-the-transcription-factor-elk3-inhibits-tumour-growth-and-metastasis-in-mice
#1
Kostyantyn Semenchenko, Christine Wasylyk, Henry Cheung, Yves Tourrette, Peter Maas, Jack A Schalken, Gabri van der Pluijm, Bohdan Wasylyk
Transcription factors have an important role in cancer but are difficult targets for the development of tumour therapies. These factors include the Ets family, and in this study Elk3 that is activated by Ras oncogene /Erk signalling, and is involved in angiogenesis, malignant progression and epithelial-mesenchymal type processes. We previously described the identification and in-vitro characterisation of an inhibitor of Ras / Erk activation of Elk3 that also affects microtubules, XRP44X. We now report an initial characterisation of the effects of XRP44X in-vivo on tumour growth and metastasis in three preclinical models mouse models, subcutaneous xenografts, intra-cardiac injection-bone metastasis and the TRAMP transgenic mouse model of prostate cancer progression...
2016: PloS One
https://www.readbyqxmd.com/read/27137807/nanomedicine-interaction-of-biomimetic-apatite-colloidal-nanoparticles-with-human-blood-components
#2
Maëla Choimet, Kim Hyoung-Mi, Oh Jae-Min, Audrey Tourrette, Christophe Drouet
This contribution investigates the interaction of two types of biomimetic-apatite colloidal nanoparticles (negatively-charged 47nm, and positively-charged 190nm NPs) with blood components, namely red blood cells (RBC) and plasma proteins, with the view to inspect their hemocompatibility. The NPs, preliminarily characterized by XRD, FTIR and DLS, showed low hemolysis ratio (typically lower than 5%) illustrating the high compatibility of such NPs with respect to RBC, even at high concentration (up to 10mg/ml)...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26117294/adsorption-of-nucleotides-on-biomimetic-apatite-the-case-of-cytidine-5-monophosphate-cmp
#3
Maëla Choimet, Audrey Tourrette, Christophe Drouet
The chemical interaction between DNA macromolecules and hard tissues in vertebrate is of foremost importance in paleogenetics, as bones and teeth represent a major substrate for the genetic material after cell death. Recently, the empirical hypothesis of DNA "protection" over time thanks to its adsorption on hard tissues was revisited from a physico-chemical viewpoint. In particular, the existence of a strong interaction between phosphate groups of DNA backbone and the surface of apatite nanocrystals (mimicking bone/dentin mineral) was evidenced on an experimental basis...
October 15, 2015: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/25699589/arabidopsis-glutaredoxin-s17-and-its-partner-the-nuclear-factor-y-subunit-c11-negative-cofactor-2%C3%AE-contribute-to-maintenance-of-the-shoot-apical-meristem-under-long-day-photoperiod
#4
Johannes Knuesting, Christophe Riondet, Carlos Maria, Inga Kruse, Noëlle Bécuwe, Nicolas König, Carsten Berndt, Sébastien Tourrette, Jocelyne Guilleminot-Montoya, Enrique Herrero, Frédéric Gaymard, Janneke Balk, Gemma Belli, Renate Scheibe, Jean-Philippe Reichheld, Nicolas Rouhier, Pascal Rey
Glutaredoxins (GRXs) catalyze the reduction of protein disulfide bonds using glutathione as a reductant. Certain GRXs are able to transfer iron-sulfur clusters to other proteins. To investigate the function of Arabidopsis (Arabidopsis thaliana) GRXS17, we applied a strategy combining biochemical, genetic, and physiological approaches. GRXS17 was localized in the nucleus and cytosol, and its expression was elevated in the shoot meristems and reproductive tissues. Recombinant GRXS17 bound Fe2S2 clusters, a property likely contributing to its ability to complement the defects of a Baker's yeast (Saccharomyces cerevisiae) strain lacking the mitochondrial GRX5...
April 2015: Plant Physiology
https://www.readbyqxmd.com/read/22617741/thick-collagen-based-3d-matrices-including-growth-factors-to-induce-neurite-outgrowth
#5
M-N Labour, A Banc, A Tourrette, F Cunin, J-M Verdier, J-M Devoisselle, A Marcilhac, E Belamie
Designing synthetic microenvironments for cellular investigations is a very active area of research at the crossroads of cell biology and materials science. The present work describes the design and functionalization of a three-dimensional (3D) culture support dedicated to the study of neurite outgrowth from neural cells. It is based on a dense self-assembled collagen matrix stabilized by 100-nm-wide interconnected native fibrils without chemical crosslinking. The matrices were made suitable for cell manipulation and direct observation in confocal microscopy by anchoring them to traditional glass supports with a calibrated thickness of ∼50μm...
September 2012: Acta Biomaterialia
https://www.readbyqxmd.com/read/21679392/new-approach-to-modulate-retinal-cellular-toxic-effects-of-high-glucose-using-marine-epa-and-dha
#6
Mélody Dutot, Violaine de la Tourrette, Roxane Fagon, Patrice Rat
BACKGROUND: Protective effects of omega-3 fatty acids against cellular damages of high glucose were studied on retinal pigmented epithelial (RPE) cells. METHODS: Retinal epithelial cells were incubated with omega-3 marine oils rich in EPA and DHA and then with high glucose (25 mM) for 48 hours. Cellular responses were compared to normal glucose (5 mM): intracellular redox status, reactive oxygen species (ROS), mitochondrial succinate deshydrogenase activity, inflammatory cytokines release and caveolin-1 expression were evaluated using microplate cytometry, ELISA and flow cytometry techniques...
2011: Nutrition & Metabolism
https://www.readbyqxmd.com/read/20694658/a-review-of-post-translational-modifications-and-subcellular-localization-of-ets-transcription-factors-possible-connection-with-cancer-and-involvement-in-the-hypoxic-response
#7
REVIEW
Céline Charlot, Hélène Dubois-Pot, Tsvetan Serchov, Yves Tourrette, Bohdan Wasylyk
Post-translational modifications and subcellular localizations modulate transcription factors, generating a code that is deciphered into an activity. We describe our current understanding of these processes for Ets factors, which have recently been recognized for their importance in various biological processes. We present the global picture for the family, and then focus on particular aspects related to cancer and hypoxia. The analysis of Post-translational modification and cellular localization is only beginning to enter the age of "omic," high content, systems biology...
2010: Methods in Molecular Biology
https://www.readbyqxmd.com/read/20037936/the-strange-case-of-dr-frankenstein-and-mr-rossum-can-dystopian-literature-be-considered-as-a-response-to-technological-breakthroughs
#8
L Tourrette
No abstract text is available yet for this article.
2001: Icon: Journal of the International Committee for the History of Technology
https://www.readbyqxmd.com/read/19968320/synthesis-texture-and-photoluminescence-of-lanthanide-containing-chitosan-silica-hybrids
#9
Fengyi Liu, Luis D Carlos, Rute A S Ferreira, João Rocha, Marta C Ferro, Audrey Tourrette, Françoise Quignard, Mike Robitzer
Three different types of photoluminescent hybrid materials containing trivalent lanthanide (Ln(3+) = Eu(3+), Tb(3+)) ions, chitosan, and silica have been prepared with different structural features. The different silica sources lead to diverse microstructures of hybrid materials, with silica being homogeneously dispersed in the chitosan materials (LnChS-H), or forming a core-shell morphology. Postsynthesis treatment is necessary for embedding the luminescent probe. The Ln(3+)-based materials have been investigated by photoluminescence spectroscopy (12-300 K)...
January 14, 2010: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/17544927/spontaneous-duplications-in-diploid-saccharomyces-cerevisiae-cells
#10
Joseph Schacherer, Yves Tourrette, Serge Potier, Jean-Luc Souciet, Jacky de Montigny
The duplication of DNA sequences is a powerful determinant of genomic plasticity and is known to be one of the key factors responsible for evolution. Recent genomic sequence data demonstrate the abundance of duplicated genes in all surveyed organisms. Over the past years, experimental systems were adequately designed to explore the molecular mechanisms involved in their formation in haploid Saccharomyces cerevisiae strains. To obtain a more global and accurate view of the events leading to DNA sequence duplications, we have selected and characterized duplication occurrences in diploid S...
October 1, 2007: DNA Repair
https://www.readbyqxmd.com/read/17493124/spontaneous-deletions-and-reciprocal-translocations-in-saccharomyces-cerevisiae-influence-of-ploidy
#11
Yves Tourrette, Joseph Schacherer, Emilie Fritsch, Serge Potier, Jean-Luc Souciet, Jacky de Montigny
Studying spontaneous chromosomal rearrangements throws light on the rules underlying the genome reshaping events occurring in eukaryotic cells, which are part of the evolutionary process. In Saccharomyces cerevisiae, translocation and deletion processes have been frequently described in haploids, but little is known so far about these processes at the diploid level. Here we investigated the nature and the frequency of the chromosomal rearrangements occurring at this ploidy level. Using a positive selection screen based on a particular mutated allele of the URA2 gene, spontaneous diploid revertants were selected and analysed...
April 2007: Molecular Microbiology
https://www.readbyqxmd.com/read/17208423/-autism-and-mental-retardation-a-study-of-the-early-social-communication
#12
M Viellard, D Da Fonseca, S De Martino, A-M Girardot, D Bastard-Rosset, H Duverger, E Genest, K Yvonnet, H Pala, C Deruelle, F Poinso
OBJECTIVE: To determine developmental communication profiles in young autistic children with mental retardation. METHODS: A group of 19 autistic children (mean age=43 months) were matched with a group of 11 mentally retarded children (mean age=39 months) on mental age (17,6 months). All of these children were without speech (less than 5 words of vocabulary). Communication skills were assessed with the Guidetti-Tourrette scales (ECSP), French adaptation of the Seibert-Hogan scales...
March 2007: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/16083892/pillaring-effects-in-macroporous-carrageenan-silica-composite-microspheres
#13
M Boissière, A Tourrette, J M Devoisselle, F Di Renzo, F Quignard
The impregnation of a carrageenan gel by a silica sol is an efficient method to form a composite material which can be conveniently activated by CO2 supercritical drying. The textural properties of the solids have been characterized by nitrogen adsorption-desorption at 77 K and their composition by thermogravimetric analysis and EDX microprobe. Morphology was examined by SEM. The silica-carrageenan composites present an open macroporous structure. Silica particles retained inside the gel behaved as pillars between the polysaccharide fibrils and form a stick-and-ball network...
February 1, 2006: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/15231745/recovery-of-a-function-involving-gene-duplication-by-retroposition-in-saccharomyces-cerevisiae
#14
Joseph Schacherer, Yves Tourrette, Jean-Luc Souciet, Serge Potier, Jacky De Montigny
The duplication of DNA sequences contributes to genomic plasticity and is known to be one of the key factors responsible for evolution. The mechanisms underlying these rare events, which have been frequently mentioned by authors performing genomic analysis, have not yet been completely elucidated. These mechanisms were approached here in the yeast Saccharomyces cerevisiae, using a positive selection screen based on a particular mutated allele of the URA2 gene. Spontaneous revertants containing a duplication of the terminal part of the URA2 gene were selected and analyzed...
July 2004: Genome Research
https://www.readbyqxmd.com/read/15164610/-neuropsychopharmacological-profile-of-nicotine
#15
REVIEW
Kiyoshi Ando
The reinforcing effects of nicotine have been investigated by intravenous self-administration methods using mice, rats, dogs, squirrel monkeys, rhesus monkeys, baboons, and humans. Based on accumulated data related to these effects, it is clear that subjects show moderate self-administration of nicotine with no marked manifestation in contrast to excessive self-administration of cocaine with hyperactivity and of morphine with withdrawal syndrome. The magnitude of reinforcing effects of nicotine was judged to be lower than that of cocaine and other abused drugs by the progressive ratio schedule method although persistent self-administration behavior for nicotine was maintained under the second-order schedule with conditioned stimulus in monkeys...
April 2004: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
https://www.readbyqxmd.com/read/14279611/-imported-amebiasis-500-cases
#16
H FELIX, F LESBRE, G TOURRETTE
No abstract text is available yet for this article.
June 1964: Bulletin de la Société de Pathologie Exotique et de Ses Filiales
https://www.readbyqxmd.com/read/14224967/-congenital-complete-atrio-ventricular-block-apropos-of-3-observations
#17
M FROMANTIN, G TOURRETTE, J OUGIER
No abstract text is available yet for this article.
October 1964: Bulletin Mensuel—Société de Médecine Militaire Française
https://www.readbyqxmd.com/read/14133439/-hydatid-cyst-of-the-left-diaphragm-with-pleuro-pulmonary-manifestations
#18
J ROUMAGOUX, M JAUBERTDEBEAUJEU, H PIROLLET, G TOURRETTE
No abstract text is available yet for this article.
1964: Le Poumon et le Coeur
https://www.readbyqxmd.com/read/14098224/-clinical-considerations-apropos-of-23-nontuberculous-pleural-effusions
#19
C TOURRETTE, PIROLLET, F MAGERAND, J ROUMAGOUX
No abstract text is available yet for this article.
November 1963: Bulletin Mensuel—Société de Médecine Militaire Française
https://www.readbyqxmd.com/read/14091606/-urinary-infectious-syndromes-and-renal-repercussions-in-the-young-adult-apropos-of-40-cases-of-ascending-nephropathy
#20
C LAVERDANT, A THABAUT, J PAPILLAUD, C TOURRETTE
No abstract text is available yet for this article.
September 28, 1963: La Presse Médicale
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