Juliette Cholet, Caroline Decombat, Laetitia Delort, Maël Gainche, Alexandre Berry, Clémence Ogeron, Isabelle Ripoche, Marjolaine Vareille-Delarbre, Marion Vermerie, Didier Fraisse, Catherine Felgines, Adrien Rossary, Edwige Ranouille, Jean-Yves Berthon, Albert Tourrette, Julien Priam, Etienne Saunier, Yves Troin, François Senejoux, Pierre Chalard, Florence Caldefie-Chézet
(1) Interest in the Juncaceae family has risen as some members have shown anti-inflammatory properties and interesting compounds. In this regard, we decided to investigate the antioxidant and anti-inflammatory properties of Luzula sylvatica , a Juncaceae not yet extensively studied, in the context of osteoarthritis. (2) The Luzula sylvatica Ethanol extract (LS-E) was used to test the production of reactive oxygen species (ROS) by leucocytes, the IL1β and PGE2 production by peripheral blood mononuclear cells (PBMCs), the production of EP4, and the activation of NFκB in THP-1, as well as the IL1β-activated normal human knee articular chondrocytes (NHAC-Kn) gene expression, grown in monolayers or maintained in alginate beads...
December 21, 2022: International Journal of Molecular Sciences