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Pelin S Çiftçi Türetken, Gülşen Altuğ
Isolation and characterization studies of marine heterotrophic bacteria are important to describe and understand eco-metobolism of the marine environments. In this study, diversity and community structures of the culturable heterotrophic bacteria, metabollicaly active bacteria and bacterial pollution in the coastal and offshore areas of Gökçeada Island, in the Northern Aegean Sea, Turkey were investigated from March 2012 to November 2013. The primary hydrographic parameters were recorded in situ. The frequency of the metabolically active bacteria was determined by using a modified staining technique...
February 2016: Environmental Monitoring and Assessment
Marija Jelić, Tatjana Cvetković, Vidojko Djordjević, Goran Damnjanovć, Predrag Vlahović, Gordana Kocić, Natasa Djindjić, Biljana Jovović, Ana Antić
BACKGROUND/AIM: [corrected] Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). METHODS: The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation...
April 2013: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Balázs Börzsönyi, Csaba Demendi, Attila Pajor, János Rigó, Krisztina Marosi, Annamária Agota, Zsolt B Nagy, József Gábor Joó
OBJECTIVE: To assess 11-β-hydroxysteroid dehydrogenase 2 (11β-HSD2) gene expression patterns in human placental samples from intrauterine growth restriction (IUGR) pregnancies using normal pregnancy as control. STUDY DESIGN: We compared 11-β-HSD2 gene expression in placental samples from all IUGR pregnancies treated in our clinic between January 1, 2010 and January 1, 2011 vs. 140 normal pregnancy samples from the same study period. Clinical characteristics were also assessed and compared between the IUGR and normal pregnancy groups...
March 2012: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Wenjun Tu, Jian He, Fang Dai, Xinyu Wang, Ying Li
OBJECTIVE: To estimate the incidence of Inborn errors of metobolism (IEM) in Neonatal intensive care unit (NICU) using tandem mass spectrometry and to determine the impact that these disorders have on NICU resources. METHODS: During the period of study, 724 (81% eligible cases) dried blood filter-paper samples were collected from a NICU. The samples were analysed using tandem mass spectrometry. The diagnosis was further confirmed through clinical symptoms and by gas chromatography-mass spectrometry...
April 2012: Indian Journal of Pediatrics
Prasad Neerati, Jyothsna Gade
Atorvastatin is a selective HMG-CoA reductase competitive inhibitor, used for the treatment of hyperlipidaemia. It is metabolized by CYP 3A4 and 3A5 isoenzymes in liver. It also has moderate inhibition on metabolizing enzymes like CYP 2C9, 2D6 and 3A4. Hence there is more possibility of atorvastatin for inhibition of metabolism of glyburide, by both CYP 2C9 and 3A4. We have studied the effects of atorvastatin on the pharmacodynamics and pharmacokinetics of glyburide in experimental diabetic rats. Atorvastatin (20mg/kg p...
February 14, 2011: European Journal of Pharmaceutical Sciences
Xiuguo Li, Jun-Shik Choi
As many anticancer agents paclitaxel is a substrate for ATP-binding cassette (ABC) transporters such as P-glycoprotein-mediated efflux, and its metabolism in humans mainly catalyzed by CYP 3A4 and 2C8. Genistein, an isoflavonoid, is supposed to be an inhibitor of some ABC transporters, and its oxidative metobolism catalyzed by CYP 3A4 and 2C8. The purpose of this study was to investigate the effect of orally administered genistein on the pharmacokinetics of paclitaxel administered through oral and intravenous (i...
June 7, 2007: International Journal of Pharmaceutics
Atsushi Ishikawa
The Arabidopsis lesion initiation 1 (len1) mutant develops lesions on leaves without pathogen attack. The len1 plants display lesion formation as they grow under short-day conditions (SD), but not under long-day conditions (LD). This study was conducted to examine how lesion formation, viz., cell death, in len1 plants occurs under SD. I present genetic and physiological data to show that tetrapyrrole metobolism is necessary for lesion formation in len1 plants. Lesion formation was suppressed in the len1lin2 double mutant under SD...
October 2005: Bioscience, Biotechnology, and Biochemistry
H Yu, Z Shen
Vitreoscilla is a Gram-negative obligate aerobic bacterium, whose most important property is the ability to produce the Vitreoscilla hemoglobin (VHb). VHb is encoded by a single gene called Vitreoscilla hemoglobin gene (vgb) containing the natural promoter, and the expression of vgb gene is regulated by dissolved oxygen at the level of transcription. The oxygen binding VHb participate in the metobolism process of cells and make them grow well in the hypoxic habitats. It also facilitates the bacteria growing and the potein producing obviously...
October 1999: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
Brian K Irons, Kathleen A Snella, Kenneth McCall, Eric J MacLaughlin, Maumi Villarreal
The third edition of guidelines from the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III]) is discussed. The most recent classifications for low-density-lipoprotein (LDL) cholesterol, high-density-lipoprotein (HDL), total cholesterol, and triglycerides are provided. LDL cholesterol goals, cardiovascular risk assessment, therapeutic goals, and pharmacologic treatment options are discussed for both primary and secondary prevention of cardiovascular disease...
September 1, 2002: American Journal of Health-system Pharmacy: AJHP
T Moss, D Howes, F M Williams
triclosan is widely used in many products that contact the skin of consumers. This study compares in vivo and in vitro skin absorption of triclosan and determines the potential of skin to metobolize it prior to entering the blood stream. After in vivo topical application of a 64.5mM alcoholic solution of [(3)H]triclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application...
April 2000: Food and Chemical Toxicology
K Alexander, P Nissen, H J Mitzkat
No abstract text is available yet for this article.
1967: Angiologica
M Nagasaka
No abstract text is available yet for this article.
December 1973: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
G Hübner, C Voss, N Hartmann
No abstract text is available yet for this article.
January 15, 1974: Zeitschrift Für die Gesamte Innere Medizin und Ihre Grenzgebiete
R E Cater
In a previous paper evidence was presented to show that Helicobacter-induced chronic gastritis is the probable cause of most chronic hypochlorhydria. In this article evidence is presented for the clinical relevance of reduced stomach acid secretion. Reduced mineral absorption is fairly well documented and has sound theoretical support from basic chemistry. Impaired digestion of protein has been suggested by a few studies. Small intestinal bacterial overgrowth in hypochlorhydria probably leads to putrefactive breakdown of the metobolically useful products of protein digestion, thereby reducing their availability for certain essential pathways...
December 1992: Medical Hypotheses
H W Heiss, J Barmeyer, K Wink, G Huber, G Hagemann, G Beiter, J Keul, H Reindell
No abstract text is available yet for this article.
1975: Verhandlungen der Deutschen Gesellschaft Für Kreislaufforschung
W Dehnen
Alveolar macrophages play a significant role in the elimination of inhaled foreign compounds and particles from the lung. The question arises, if alveolar macrophages participate in the detoxification or activation of environmental carcinogenic compounds. In the first communication on this subject we describe experiments concerning the uptake of benzo(a)pyrene and the activity of the metobolizing enzymes. The alveolar macrophages are obtained by lung lavage from guinea pigs (Fig. 1,2,3). The cells are grown in monolayers in petri dishes or on the surface of cover slips or glass-vials...
May 1975: Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Präventive Medizin
H G Selander, D M Jerina, J W Daly
No abstract text is available yet for this article.
May 1975: Archives of Biochemistry and Biophysics
A Hagen, R Lahl
Frequency and appearance of atypical macroglia in the frontal cortex and striatum in 400 human brains of cases with non-hepatogenic diseases were investigated and compared with results in 150 human brains of cases with severe liver diseases. Quantitative and qualitative differences between the non-hepatogenic (I---III) and hepatogenic (IV) groups were statistically significant. Evidence for the so-called Alzheimer-II-cells could only be obtained in metobolic disturbances of hepatogenic origin and in a few cases of cerebral coma...
1978: Zentralblatt Für Allgemeine Pathologie und Pathologische Anatomie
R Karler
No abstract text is available yet for this article.
July 1977: NIDA Research Monograph
Y Hasumura, J Takeuchi
Alcohol interacts with a number of drugs in a paradoxical way; when alcohol and drugs are coingested, effect of drug on the body appears to be prolonged and enhanced, not only by additive process at the target organ but also by means of impaired absorption and metabolism of drug (= drug tolerance). By contrast, chronic alcoholics, who have proliferated endoplasmic reticulum and adaptively induced drug-metabolizing enzymes in the liver, when sober, require larger doses of drug than usually in order to produce a proper effect (= drug tolerance)...
October 1978: Leber, Magen, Darm
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