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https://www.readbyqxmd.com/read/28205456/histochemical-study-of-encephalitozoon-cuniculi-spores-in-the-kidneys-of-naturally-infected-new-zealand-rabbits
#1
Luis E Rodríguez-Tovar, Alejandra Villarreal-Marroquín, Alicia M Nevárez-Garza, Uziel Castillo-Velázquez, Heidi G Rodríguez-Ramírez, Magda C Navarro-Soto, Juan J Zárate-Ramos, Gustavo Hernández-Vidal, Armando Trejo-Chávez
Encephalitozoon cuniculi is an important microsporidian pathogen that is considered an emergent, zoonotic, and opportunistic. It infects both domestic and laboratory rabbits, generating severe chronic interstitial and granulomatous nephritis with fibrosis and granulomatous encephalitis. Encephalitozoonosis is diagnosed in paraffin-embedded sections by examining the spores in the host tissues. The spores are difficult to observe when the samples are stained with hematoxylin and eosin (H&E), particularly when there is an inflammatory reaction and tissue damage...
February 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28202682/protein-s-palmitoylation-in-cellular-differentiation
#2
REVIEW
Mingzi M Zhang, Howard C Hang
Reversible protein S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity, as well as protein-protein and membrane-protein associations. Enabled by technological advances, global studies revealed S-palmitoylation to be an important and pervasive posttranslational modification in eukaryotes with the potential to coordinate diverse biological processes as cells transition from one state to another. Here, we review the strategies and tools to analyze in vivo protein palmitoylation and interrogate the functions of the enzymes that put on and take off palmitate from proteins...
February 8, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28202022/hematologic-manifestations-of-babesiosis
#3
REVIEW
Tamer Akel, Neville Mobarakai
BACKGROUND: Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in humans that is attracting attention worldwide. Most cases of human babesiosis are reported in the United States and Europe. The disease is caused by the protozoa of the genus Babesia, which invade human erythrocytes and lyse them causing a febrile hemolytic anemia. The infection is usually asymptomatic or self-limited in the immunocompetent host, or follows a persistent, relapsing, and/or life threatening course with multi-organ failure, mainly in the splenectomized or immunosuppressed patients...
February 15, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28198506/inhibition-of-mitochondrial-calcium-uptake-1-in-drosophila-neurons
#4
P G M'Angale, B E Staveley
The mitochondrial calcium uptake 1 (MICU1) is a regulatory subunit of the mitochondrial calcium uniporter that plays an important role in calcium sensing. It contains two EF-hand domains that are well conserved across diverse species from protozoa to plants and metazoans. The loss of MICU1 function in mammals is attributed to several neurological disorders that involve movement dysfunction. The CG4495 gene in Drosophila melanogaster was identified as a putative homolog of MICU1 in the HomoloGene database of the National Centre for Biotechnology Information (NCBI)...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28197133/metatranscriptomics-reveals-the-active-bacterial-and-eukaryotic-fibrolytic-communities-in-the-rumen-of-dairy-cow-fed-a-mixed-diet
#5
Sophie Comtet-Marre, Nicolas Parisot, Pascale Lepercq, Frédérique Chaucheyras-Durand, Pascale Mosoni, Eric Peyretaillade, Ali R Bayat, Kevin J Shingfield, Pierre Peyret, Evelyne Forano
Ruminants have a unique ability to derive energy from the degradation of plant polysaccharides through the activity of the rumen microbiota. Although this process is well studied in vitro, knowledge gaps remain regarding the relative contribution of the microbiota members and enzymes in vivo. The present study used RNA-sequencing to reveal both the expression of genes encoding carbohydrate-active enzymes (CAZymes) by the rumen microbiota of a lactating dairy cow and the microorganisms forming the fiber-degrading community...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28187346/hydrologic-land-cover-and-seasonal-patterns-of-waterborne-pathogens-in-great-lakes-tributaries
#6
P L Lenaker, S R Corsi, M A Borchardt, S K Spencer, A K Baldwin, M A Lutz
Great Lakes tributaries are known to deliver waterborne pathogens from a host of sources. To examine the hydrologic, land cover, and seasonal patterns of waterborne pathogens (i.e. protozoa (2), pathogenic bacteria (4) human viruses, (8) and bovine viruses (8)) eight rivers were monitored in the Great Lakes Basin over 29 months from February 2011 to June 2013. Sampling locations represented a wide variety of land cover classes from urban to agriculture to forest. A custom automated pathogen sampler was deployed at eight sampling locations which provided unattended, flow-weighted, large-volume (120-1630 L) sampling...
February 7, 2017: Water Research
https://www.readbyqxmd.com/read/28187061/bronchopulmonary-disease-caused-by-flagellated-protozoa-infection-in-15-chinese-children
#7
Jinrong Liu, Shaogang Li, Huimin Li, Yimu Fan, Haiming Yang, Hui Xu, Yuelin Shen, Shunying Zhao
BACKGROUND: Bronchopulmonary disease caused by flagellated protozoa infection (BPFP) is thought to be rare in children but may be an emerging or underestimated disease, especially in developing countries. METHODS: In this study, we retrospectively reviewed records of 15 patients who presented with a cough, wheezing, or bronchopulmonary disease of unknown causes at admission and were finally diagnosed with BPFP from January 2014 to January 2015 were enrolled. Protozoa were observed in bronchoalveolar lavage fluid by light microscopy...
December 13, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28185826/chaetocin-a-histone-methyltransferase-inhibitor-impairs-proliferation-arrests-cell-cycle-and-induces-nucleolar-disassembly-in-trypanosoma-cruzi
#8
Aline Araujo Zuma, Jean de Oliveira Santos, Isabela Mendes, Wanderley de Souza, Carlos Renato Machado, E Maria Cristina M Motta
The Trypanosomatidae family includes pathogenic species of medical and veterinary interest. Chagas disease is endemic in Latin America, and about 8 million people are infected worldwide. There is a need for more effective drugs for the acute, undetermined and chronic phases of the disease that, in addition, do not cause side effects, stimulating the search for identification of new drug targets, as well as new chemotherapeutic targets. Trypanosomatids contain characteristic structures, such as the nucleus that undergoes a closed mitosis without chromosome formation and variations of chromatin packing in the different protozoa developmental stages...
February 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28185379/feed-degradability-rumen-fermentation-and-blood-metabolites-in-response-to-essential-oil-addition-to-fistulated-non-lactating-dairy-cow-diets
#9
Wisitiporn Suksombat, Atitthan Nanon, Chayapol Meeprom, Pipat Lounglawan
The effects of essential oils (EOs) on ruminal nutrient disappearance, rumen fermentation and blood metabolites in fistulated non-lactating dairy cows were studied. Four fistulated non-lactaing dairy cows were used in a 4 × 4 Latin square design; the experiment consisted of four periods of 21 days in each period, with the first 14 days for adaptation followed by 7 days of measurement period. Animals were fed 3 kg/day of 21% crude protein (CP) concentrate and ad libitum corn silage. Treatments were: (i) control; (ii) 2 mL Allicin/cow/day; (iii) 2 mL zingiberene/cow/day; and (iv) 2 mL citral/cow/day...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28183814/comparative-proteomics-of-purified-pathogen-vacuoles-correlates-intracellular-replication-of-legionella-pneumophila-with-the-small-gtpase-rap1
#10
Johanna Schm Oumllders, Christian Manske, Andreas Otto, Christine Hoffmann, Bernhard Steiner, Amanda Welin, D Oumlrte Becher, Hubert Hilbi
Legionella pneumophila is an opportunistic bacterial pathogen that causes a severe lung infection termed Legionnaires disease. The pathogen replicates in environmental protozoa as well as in macrophages within a unique membrane-bound compartment, the Legionella-containing-vacuole (LCV). LCV formation requires the bacterial Icm/Dot type IV secretion system, which translocates ca. 300 effector proteins into host cells, where they target distinct host factors. The L. pneumophila pentuple mutant (Δpentuple) lacks 5 gene clusters (31% of the effector proteins) and replicates in macrophages but not in Dictyostelium discoideum amoeba...
February 9, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28182579/synthesis-and-biological-evaluation-of-newer-1-3-4-oxadiazoles-incorporated-with-benzothiazepine-and-benzodiazepine-moieties
#11
Patel Navin, Patel Sarvil, Purohit Amit, Patel Divyesh, Rajani Dhansukh, Rosa Moo-Puc, Gildardo Rivera
A series of thiazepines and diazepines having 1,3,4-oxadiazole moiety were synthesized, and they were analyzed for their in vitro antimicrobial activity against several bacteria (Staphylococcus aureus, Staphylococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger, and Aspergillus Clavatus) and protozoa (Entamoeba histolytica, Giardia lamblia, Trypanosoma cruzi and Leishmania mexicana). Few of the selected compounds were tested for their antitubercular activity...
February 9, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28179027/genome-scaffolding-and-annotation-for-the-pathogen-vector-ixodes-ricinus-by-ultra-long-single-molecule-sequencing
#12
Wibke J Cramaro, Oliver E Hunewald, Lesley Bell-Sakyi, Claude P Muller
BACKGROUND: Global warming and other ecological changes have facilitated the expansion of Ixodes ricinus tick populations. Ixodes ricinus is the most important carrier of vector-borne pathogens in Europe, transmitting viruses, protozoa and bacteria, in particular Borrelia burgdorferi (sensu lato), the causative agent of Lyme borreliosis, the most prevalent vector-borne disease in humans in the Northern hemisphere. To faster control this disease vector, a better understanding of the I...
February 8, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28177373/a-strategy-to-improve-nitrogen-utilization-reduce-environmental-impact-and-increase-performance-and-antioxidant-capacity-of-fattening-lambs-using-pomegranate-peel-extract
#13
M Rajabi, Y Rouzbehan, J Rezaei
Dietary natural plant secondary metabolites (PSM) extracted from a pomegranate peel (PP) byproduct have the potential to improve milk yield and the milk fatty acid profile of dairy cows. This experiment was performed to assess the influence of different dietary levels of PP extract (PPE) on feedlot performance, ruminal status, nutrient utilization, and antioxidant status in fattening Moghani lambs. Thirty-two lambs (initial BW of 22 ± 1.2 kg) were used in a completely randomized design with a 72-d period and 4 treatments: PPE0 (no extract), PPE15 (15 mL PPE/kg of diet DM), PPE30 (30 mL PPE/kg of diet DM), and PPE45 (45 mL PPE/kg of diet DM)...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28172850/p144-protozoa-and-bacterial-infections-are-relevant-for-clinical-outcomes-in-ulcerative-colitis-a-study-from-latin-american-country
#14
Y Gutierrez-Grobe, C Barrera-Ochoa, J Yamamoto-Furusho
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168399/prevalence-and-risk-factors-of-cryptosporidium-infection-in-farmed-pigs-in-zhejiang-guangdong-and-yunnan-provinces-china
#15
Yang Zou, Jian-Gang Ma, Dong-Mei Yue, Wen-Bin Zheng, Xiao-Xuan Zhang, Quan Zhao, Xing-Quan Zhu
Cryptosporidiosis is caused by species of Cryptosporidium protozoa that can infect a wide range of host animals worldwide. However, data regarding Cryptosporidium infection in farmed pigs in subtropical areas in China is limited. Therefore, a total of 396 fecal samples were obtained from farmed pigs from Zhejiang (n = 124), Guangdong (n = 72), and Yunnan (n = 200) provinces, China, and were tested by PCR amplification of the small subunit (SSU) rRNA gene. The overall prevalence of Cryptosporidium in pigs was 17...
February 6, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28167597/epidemiology-of-soil-transmitted-helminth-and-intestinal-protozoan-infections-in-preschool-aged-children-in-the-amhara-region-of-ethiopia
#16
Kristen Aiemjoy, Sintayehu Gebresillasie, Nicole E Stoller, Ayalew Shiferaw, Zerihun Tadesse, Melsew Chanyalew, Solomon Aragie, Kelly Callahan, Jeremy D Keenan
Intestinal parasites are important contributors to global morbidity and mortality and are the second most common cause of outpatient morbidity in Ethiopia. This cross-sectional survey describes the prevalence of soil-transmitted helminths and intestinal protozoa in preschool children 0-5 years of age in seven communities in the Amhara region of Ethiopia, and investigates associations between infection, household water and sanitation characteristics, and child growth. Stool samples were collected from children 0-5 years of age, 1 g of sample was preserved in sodium acetate-acetic acid-formalin, and examined for intestinal helminth eggs and protozoa cysts ether-concentration method...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28167559/anti-trypanosomal-activity-of-sterol-14%C3%AE-demethylase-cyp51-inhibitors-vni-and-vfv-in-the-swiss-mouse-models-of-chagas-disease-induced-by-the-y-strain-trypanosoma-cruzi
#17
F H Guedes-da-Silva, D G J Batista, C F Da Silva, J S De Araújo, B P Pavão, M R Simões-Silva, M B Meuser, K C Demarque, O C Moreira, C Britto, G I Lepesheva, M N C Soeiro
Chagas disease is a life-threatening infection caused by a variety of genetically diverse strains of the protozoan parasite Trypanosoma cruzi The current treatment (benznidazole and nifurtimox) is unsatisfactory, and potential alternatives include inhibitors of sterol 14α-demethylase (CYP51), the cytochrome P450 enzyme essential for biosynthesis of sterols in eukaryotes and the major target for clinical and agricultural antifungals. Here we performed a comparative investigation of two protozoa-specific CYP51 inhibitors, VNI and its CYP51 structure-based derivative VFV, in the murine models of infection caused by the Y strain T...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28164484/significance-of-nitric-oxide-level-in-giardiasis
#18
Mitra Zarebavani, Delaram Dargahi, Nahid Einollahi, Nasrin Dashti, Fatemeh Safari, Mostafa Rezaeian
BACKGROUND: Giardiasis is one of the most prevalent intestinal protozoa infections in humans. Nowadays, nitric oxide (NO) is known to be involved in the immune system against Giardia intestinalis. Therefore, the aim of the present study was to evaluate the level of NO in individuals with giardiasis in comparison to normal subjects. METHODS: This descriptive study was conducted among 49 Giadia positive and 39 age and gender matched healthy volunteers. Examination of stool samples was done by wet mount technique and formol-ether concentration method...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28163258/proteomics-tracing-the-footsteps-of-infectious-disease
#19
Todd M Greco, Ileana M Cristea
Every year, a major cause of human disease and death worldwide is infection with the various pathogens - viruses, bacteria, fungi, and protozoa - that are intrinsic to our ecosystem. In efforts to control the prevalence of infectious disease and develop improved therapies, the scientific community has focused on building a molecular picture of pathogen infection and spread. These studies have been aimed at defining the cellular mechanisms that allow pathogen entry into hosts cells, their replication and transmission, as well as the core mechanisms of host defense against pathogens...
February 5, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28161848/eukaryotic-molecular-diversity-at-different-steps-of-the-wastewater-treatment-plant-process-reveals-more-phylogenetic-novel-lineages
#20
Rakia Chouari, Marie Leonard, Moez Bouali, Sonda Guermazi, Naima Rahli, Ines Zrafi, Loïc Morin, Abdelghani Sghir
Wastewater microbiota represents important actors of organic depollution. Nowadays, some species used as bioindicators of the effluent quality are still identified by microscopy. In the present study, we investigated eukaryotic diversity at the different steps of the treatment process of a wastewater treatment plant (aerobic, anaerobic, clarifier basins and anaerobic digester) using the 18S rRNA gene sequencing approach. Of the 1519 analysed sequences, we identified 160 operational taxonomic units. Interestingly, 56...
March 2017: World Journal of Microbiology & Biotechnology
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