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Diabetes and metabolic syndrome

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https://www.readbyqxmd.com/read/29053727/impaired-glucose-metabolism-in-subjects-with-the-williams-beuren-syndrome-a-five-year-follow-up-cohort-study
#1
Maria Elena Lunati, Maria Francesca Bedeschi, Veronica Resi, Valeria Grancini, Eva Palmieri, Simona Salera, Faustina Lalatta, Giuseppe Pugliese, Emanuela Orsi
OBJECTIVE: The Williams-Beuren syndrome (WS) is associated with impaired glucose metabolism (IGM) early in adulthood. However, the pathophysiology of IGM remains poorly defined, due to the lack of longitudinal studies investigating the contribution of β-cell dysfunction and impaired insulin sensitivity. This study aimed at assessing incidence of IGM and the underlying mechanisms in WS adults. METHODS: This observational, longitudinal (5-year), cohort study enrolled thirty-one consecutive WS subjects attending a tertiary referral center...
2017: PloS One
https://www.readbyqxmd.com/read/29052905/metabolic-changes-in-patients-with-prostate-cancer-during-androgen-deprivation-therapy
#2
REVIEW
Koji Mitsuzuka, Yoichi Arai
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture...
October 20, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29052766/decreased-diabetes-risk-over-9%C3%A2-year-after-18-month-oral-l-arginine-treatment-in-middle-aged-subjects-with-impaired-glucose-tolerance-and-metabolic-syndrome-extension-evaluation-of-l-arginine-study
#3
Lucilla D Monti, Elena Galluccio, Valentina Villa, Barbara Fontana, Serena Spadoni, Pier Marco Piatti
PURPOSE: This study aimed to determine whether L-arginine supplementation lasting for 18 months maintained long-lasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes. METHODS: One hundred and forty-four middle-aged subjects with impaired glucose tolerance and metabolic syndrome were randomized in 2006 to an L-arginine supplementation (6...
October 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29052439/predictors-of-mortality-in-hospital-survivors-with-type-2-diabetes-mellitus-and-acute-coronary-syndromes
#4
Stefano Savonitto, Nuccia Morici, Anna Nozza, Francesco Cosentino, Pasquale Perrone Filardi, Ernesto Murena, Giorgio Morocutti, Marco Ferri, Claudio Cavallini, Marinus Jc Eijkemans, Barbara E Stähli, Ilse C Schrieks, Tadashi Toyama, H J Lambers Heerspink, Klas Malmberg, Gregory G Schwartz, A Michael Lincoff, Lars Ryden, Jean Claude Tardif, Diederick E Grobbee
AIM: To define the predictors of long-term mortality in patients with type 2 diabetes mellitus and recent acute coronary syndrome. METHODS AND RESULTS: A total of 7226 patients from a randomized trial, testing the effect on cardiovascular outcomes of the dual peroxisome proliferator-activated receptor agonist aleglitazar in patients with type 2 diabetes mellitus and recent acute coronary syndrome (AleCardio trial), were analysed. Median follow-up was 2 years. The independent mortality predictors were defined using Cox regression analysis...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29051041/retinal-vasculature-and-5-year-metabolic-syndrome-among-women-with-gestational-diabetes-mellitus
#5
Ling-Jun Li, Kok Hian Tan, Izzuddin M Aris, Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Yap Seng Chong, Seang Mei Saw, Peter Gluckman, Tien Yin Wong, Ecosse Lamoureux
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at greater risk of metabolic syndrome (MetS). We studied the association between second-trimester retinal microvasculature and 5-year MetS incidence in women with GDM. METHODS: A total of 142 mothers with GDM were recruited and followed up 5 years after delivery. Retinal photography was performed at 26-28 weeks gestation and metabolic outcomes were assessed at the 5-year postpartum follow-up visit. GDM and MetS were defined based on World Health Organization (WHO) guidelines and Adults Treatment Panel (ATP) III guidelines, respectively...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29051034/pre-operative-and-post-operative-changes-in-crp-and-other-biomarkers-sensitive-to-inflammatory-status-in-patients-with-severe-obesity-undergoing-laparoscopic-sleeve-gastrectomy
#6
Edward W Randell, Laurie K Twells, Deborah M Gregory, Kendra K Lester, Noriko Daneshtalab, Carla Dillon, David Pace, Chris Smith, Darrell Boone
INTRODUCTION: C-reactive protein (CRP) is often elevated in patients living with severe obesity (BMI≥35kg/m(2)). However, there is limited information on how CRP, and other inflammation responsive biomarkers, change in response to weight loss following laparoscopic sleeve gastrectomy (LSG). We studied how CRP, ferritin and albumin change following LSG surgery in relation to obesity, metabolic syndrome (MetS) ATPIII risk components and diabetes mellitus (DM). METHODS: Laboratory parameters (including CRP) were examined in 197 patients prior to LSG, and at 6, 12, 18 and 24months...
October 16, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29050977/prophylactic-role-of-taurine-and-its-derivatives-against-diabetes-mellitus-and-its-related-complications
#7
REVIEW
Poulami Sarkar, Priyanka Basak, Sumit Ghosh, Mousumi Kundu, Parames C Sil
Taurine is a conditionally essential amino acid present in the body in free form. Mammalian taurine is synthesized in the pancreas via the cysteine sulfinic acid pathway. Anti-oxidation and anti-inflammation are two main properties through which it exerts its therapeutic effects. Many studies have shown its excellent therapeutic potential against diabetes mellitus and related complications like diabetic neuropathy, retinopathy, nephropathy, hematological dysfunctions, reproductive dysfunctions, liver and pancreas related complications etc...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29050917/sugar-intake-in-sudanese-individuals-was-associated-with-some-features-of-the-metabolic-syndrome-population-based-study
#8
Eman F El-Sayed, Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Amel A Sulaiman, Ahmed O Almobarak, Mohamed H Ahmed
AIM: The aim of this study was to assess the level of sugar intake among Sudanese individuals. MATERIALS AND METHODS: A cross-sectional study with 323 participants. Respondents were grouped by the total intake of added sugars into two groups, one group with sugar intake more than 200 calories per day and other group with sugar intake less than 200 calories per day. Demographic data were collected with anthropometric measurements like body mass index (BMI) and waist circumference...
October 13, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29049309/validation-of-surrogate-markers-for-metabolic-syndrome-and-cardiometabolic-risk-factor-clustering-in-children-and-adolescents-a-nationwide-population-based-study
#9
Ji-Young Seo, Jae Hyun Kim
Prevalence of metabolic syndrome (MetS) in children is increasing and identifying the risk factors for MetS during childhood is an important first step to prevent chronic diseases later in life. The aim of the present study was to evaluate the prevalence of MetS and cardiometabolic risk factor (CMRF) clustering among Korean children and adolescents and to validate the associated anthropometric and laboratory surrogate markers. We used data from the 2011-2014 Korean National Health and Nutrition Examination Survey...
2017: PloS One
https://www.readbyqxmd.com/read/29049200/subclinical-atherosclerosis-and-history-of-cardiovascular-events-in-italian-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-multicenter-girrcs-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-study
#10
Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Federica Macaluso, Daniela Iacono, Francesca D'Onofrio, Giacomo Emmi, Fabiola Atzeni, Marcella Prete, Federico Perosa, Piercarlo Sarzi-Puttini, Lorenzo Emmi, Francesco Paolo Cantatore, Giovanni Triolo, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini
Several studies have pointed out a significant association between rheumatoid arthritis (RA) and accelerated atherosclerosis. At the best of our knowledge, no such study has been carried out in a large Italian series and, in this study, we aimed to investigate the prevalence of both subclinical atherosclerosis and history of cardiovascular events (CVEs), in patients consecutively admitted from January 1, 2015 to December 31, 2015 to Rheumatology Units throughout the whole Italy.Centers members of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) were invited to enrol patients consecutively admitted from January 1, 2015 to December 31, 2015 and satisfying American College of Rheumatology/ European League Against Rheumatism criteria for RA and to investigate each of them for: traditional cardiovascular risk factors: sex, age, smoking habit, total cholesterol, triglycerides, glycaemia, high blood pressure, metabolic syndrome (MS), type 2 diabetes (T2D); RA features: disease duration as assessed from the first symptom, disease activity as evaluated by DAS28, radiographic damage as assessed by hands and feet x-ray, and previous joint surgery; prevalence of both subclinical atherosclerosis and history of CVEs...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048462/obesity-induced-vascular-dysfunction-and-arterial-stiffening-requires-endothelial-cell-arginase-1
#11
Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A Toque, Jijun Chen, Reem T Atawia, Abdelrahman Y Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B Caldwell, Robert W Caldwell
Aims: Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive L-arginine metabolism towards the production of ornithine, polyamines, and proline, promoting proliferation of vascular smooth muscle cells and collagen formation, leading to perivascular fibrosis. We hypothesized that there is a specific involvement of arginase 1 expression within the vascular endothelial cells in this pathology...
September 7, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29048380/hop-phytochemicals-and-their-potential-role-in-metabolic-syndrome-prevention-and-therapy
#12
REVIEW
Pavel Dostálek, Marcel Karabín, Lukáš Jelínek
Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29045709/joint-effect-of-physical-activity-and-sedentary-behaviour-on-cardiovascular-risk-factors-in-chilean-adults
#13
Carlos Cristi-Montero, Lewis Steell, Fanny Petermann, Alex Garrido-Méndez, Ximena Díaz-Martínez, Carlos Salas-Bravo, Rodrigo Ramirez-Campillo, Cristian Alvarez, Fernando Rodriguez, Nicolas Aguilar-Farias, Maria A Martinez, Ana M Leiva, Felipe Poblete-Valderrama, Naomi D Willis, Carlos A Celis-Morales
Background: To investigate the associations between combined categories of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) with markers of adiposity and cardiovascular risk in adults. Methods: Overall, 5040 participants (mean age 46.4 years and 59.3% women) from the cross-sectional Chilean National Health Survey 2009-2010 were included in this study. MVPA and SB were measured using the Global Physical Activity questionnaire. Four categories were computed using MVPA- and SB-specific cut-offs ('High-SB & Active', 'Low-SB & Active', 'High-SB & Inactive' and 'Low-SB & Inactive')...
October 17, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29044551/disordered-eating-and-obesity-associations-between-binge-eating-disorder-night-eating-syndrome-and-weight-related-comorbidities
#14
REVIEW
Courtney McCuen-Wurst, Madelyn Ruggieri, Kelly C Allison
Binge-eating disorder (BED) and night-eating syndrome (NES) are two forms of disordered eating associated with overweight and obesity. While these disorders also occur in nonobese persons, they seem to be associated with weight gain over time and higher risk of diabetes and other metabolic dysfunction. BED and NES are also associated with higher risk of psychopathology, including mood, anxiety, and sleep problems, than those of similar weight status without disordered eating. Treatments are available, including cognitive behavior therapy (CBT), interpersonal psychotherapy, lisdexamfetamine, and selective serotonin reuptake inhibitors (SSRIs) for BED; and CBT, SSRIs, progressive muscle relaxation, and bright light therapy for NES...
October 16, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29044354/protocol-for-the-evaluation-of-a-chronic-care-model-experience-in-rome
#15
D Mipatrini, A Sinopoli, C Sestili, M Di Marcoberardino, P Giuliani, G Grasso, A Lancia, E Megli, R Mete, M G Pennafina, M Pirrò, S Tartaglia, F Vero, G La Torre
INTRODUCTION: Chronic diseases are the leading cause of death and disability in almost all over the world; in Europe causing over 9 million deaths per year according to WHO estimates. A promising health organization model for chronic disease management is represented by the Chronic Care Model (CCM). In the 12th district of the ASL Roma 2 since 4 years was implemented a CCM for the management of patients affected by diabetes and/or at high cardiovascular risk. OBJECTIVE: Aim of this study is to evaluate the effectiveness of the Chronic Care Model (CCM) for the management of chronic disease in terms of mortality reduction, avoidable hospitalizations reduction and improvement of clinical parameters...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29044172/circulating-mir-19b-and-mir-181b-are-potential-biomarkers-for-diabetic-cardiomyopathy
#16
Camila Uribe Copier, Luis León, Mauricio Fernández, David Contador, Sebastián D Calligaris
Diabetic cardiomyopathy is characterized by metabolic changes in the myocardium that promote a slow and silent dysfunction of muscle fibers, leading to myocardium remodelling and heart failure, independently of the presence of coronary artery diseases or hypertension. At present, no imaging methods allow an early diagnosis of this disease. Circulating miRNAs in plasma have been proposed as biomarkers in the prognosis of several cardiac diseases. This study aimed to determine whether circulating miRNAs could be potential biomarkers of diabetic cardiomyopathy...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043143/focal-segmental-glomerulosclerosis-associated-with-mitochondrial-disease
#17
Kenneth Lim, David Steele, Andrew Fenves, Ravi Thadhani, Eliot Heher, Amel Karaa
Primary mitochondrial diseases (MD) are complex, heterogeneous inherited diseases caused by mutations in either the mitochondrial or nuclear DNA. Glomerular diseases in MD have been reported with tRNA mutation m.3243A>G causing a syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We describe here a case of focal segmental glomerulosclerosis (FSGS) associated with a new tRNA mutation site. A 34-year-old man with a history of living related kidney transplantation, diabetes, hearing loss, and developmental delay presented to the outpatient clinic with complaints of new behavioral difficulties, worsening symptoms, and brain involvement on imaging...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29042391/korean-obesity-surgical-treatment-study-kobess-protocol-of-a-prospective-multicentre-cohort-study-on-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#18
Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo
INTRODUCTION: Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. METHODS AND ANALYSIS: The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040050/latent-autoimmune-diabetes-in-adults-in-north-indian-region-assessment-of-%C3%AE-cell-function-metabolic-and-immunological-features
#19
Alok Kumar, Alberto de Leiva
BACKGROUND: We undertook a study to assess β-cell function and metabolic and immunological features of patients with latent autoimmune diabetes in adults (LADA) and assess heterogeneity within LADA based on low and high glutamic acid decarboxylase autoantibodies (GADA) titers. METHODS: A total of 139 patients with adult-onset diabetes were examined cross-sectionally in the National capital region of Northern India. Medical history of all subjects was reviewed with the aim of collecting clinical data...
October 17, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29033611/stable-ischemic-heart-disease-in-women-current-perspectives
#20
REVIEW
Fatima Samad, Anushree Agarwal, Zainab Samad
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] >25 kg/m(2)), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases...
2017: International Journal of Women's Health
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