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Diabetes and metabolic syndrome

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https://www.readbyqxmd.com/read/29906708/biochemical-derangements-related-to-metabolic-syndrome-in-epileptic-patients-on-treatment-with-valproic-acid
#1
Yadav Nisha, Zachariah Bobby, Vaibhav Wadwekar
PURPOSE: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid. METHODS: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study...
June 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29906034/schmidt%C3%A2-s-syndrome-a-difficult-diagnosis-in-the-latin-american-context
#2
Claudia Barreda-Velit, Rodrigo Salcedo-Pereda, Jesús Ticona
Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. The diagnosis consists in the concomitant presentation of Addison disease, autoimmune thyroid disease and other autoimmune endocrinological conditions. The aim of this paper is to describe a case of Schmidt’s syndrome in the peruvian context and to analyze the difficulties in the diagnosis. Clinical case: We present the case of a 43-year-old woman that presents to the emergency room with headache, nausea, vomits and a “syncope episode”...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905009/history-of-gestational-diabetes-and-future-cardiovascular-disease-what-have-we-learned
#3
Cherng-Lan Hsu, Wayne H-H Sheu
It is well established that history of gestational diabetes mellitus (GDM) will increase risks of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (DM) and often subsequently link to future risk of cardiovascular disease (CVD). Recommendations from The American Diabetes Association (ADA) indicates that GDM is one of risk factors for future CVD in women based on previous evidence showing strong associations between GDM and CVD, such as myocardial infarction and stroke1 . However, most of those relationships were obtained from analysis of retrospective data...
June 15, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29904722/underrated-enemy-from-nonalcoholic-fatty-liver-disease-to-cancers-of-the-gastrointestinal-tract
#4
REVIEW
Aleksandra Derra, Martyna Bator, Tomasz Menżyk, Michał Kukla
Nonalcoholic fatty liver disease (NAFLD) is intrahepatic ectopic lipid deposition which is present despite a lack of other causes of secondary hepatic fat accumulation. It is the most common chronic liver disorder in the welldeveloped countries. NAFLD is a multidisciplinary disease that affects various systems and organs and is inextricably linked to simple obesity, metabolic syndrome, insulin resistance and overt diabetes mellitus type 2. The positive energy balance related to obesity leads to a variety of systemic changes including modified levels of insulin, insulin- like growth factor-1, adipokines, hepatokines and cytokines...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904633/physiology-of-hyperuricemia-and-urate-lowering-treatments
#5
REVIEW
Caroline L Benn, Pinky Dua, Rachel Gurrell, Peter Loudon, Andrew Pike, R Ian Storer, Ciara Vangjeli
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29903689/interplay-between-epicardial-adipose-tissue-metabolic-and-cardiovascular-diseases
#6
Olga Bornachea, Angela Vea, Vicenta Llorente-Cortes
Cardiovascular disease is the primary cause of death in obese and diabetic patients. In these groups of patients, the alterations of epicardial adipose tissue (EAT) contribute to both vascular and myocardial dysfunction. Therefore, it is of clinical interest to determine the mechanisms by which EAT influences cardiovascular disease. Two key factors contribute to the tight intercommunication among EAT, coronary arteries and myocardium. One is the close anatomical proximity between these tissues. The other is the capacity of EAT to secrete cytokines and other molecules with paracrine and vasocrine effects on the cardiovascular system...
June 11, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29903175/-prevalence-of-metabolic-syndrome-and-its-family-factors-for-children-and-adolescents-in-chongqing-city-in-2014
#7
Xuting Cheng, Hong Wang, Baocheng Yuan, Peiyu Guan, Lingyi Wang
OBJECTIVE: To study the prevalence and family factors on metabolic syndrome( MS) in children and adolescents for Chongqing City. METHODS: Multi-stage cluster sampling was used to recruit 1309 children and adolescents between 10 and 17 years old for physical examination( height, weight, waist circumference and blood pressure), blood biochemical examination( fasting plasma glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol)and questionnaire for family factors( breast feeding, delivery mode, birth weight, education of parents, height and weight of parents, family history of hypertension and diabetes, and so on)...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902116/association-between-the-modified-dietary-approaches-to-stop-hypertension-and-metabolic-syndrome-in-postmenopausal-women-without-diabetes
#8
Seok Hui Kang, Kyu Hyang Cho, Jun Young Do
BACKGROUND: The aim of our study was to evaluate the association between the dietary approaches to stop hypertension (DASH) and metabolic syndrome in postmenopausal Korean women without diabetes. METHODS: Our study enrolled postmenopaual women without diabetes (n = 6826). We used the DASH-Korean quartile (KQ) model using six nutrients. For protein, fiber, calcium, and potassium, we scored 1 for the first quartile (1Q), 2 for the second quartile (2Q), 3 for the third quartile (3Q), and 4 for the fourth quartile (4Q)...
June 14, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29901625/high-density-lipoprotein-cholesterol-functionality-and-metabolic-syndrome-protocol-for-review-and-meta-analysis
#9
Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai
INTRODUCTION: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900890/latent-tuberculosis-infection-among-patients-with-coronary-artery-stenosis-a-case-control-study
#10
Ahmad Farooq Alsayed Hasanain, Khalid M El-Maghraby, Ali A H Zayed, Amany M A Nafee, Sherif M Abdel-Aal, Sally M Bakkar
Background: The activation of the cell-mediated immune responses by Mycobacterium tuberculosis can promote atherogenesis. Aims: The aim of this study is to determine the frequency of latent tuberculosis infection (LTBI) among patients with coronary artery stenosis (CAS) and to explore the association between LTBI and development of CAS. We conducted a case-control study which included 183 patients' who underwent percutaneous coronary angiography (121 patients with CAS and 62 patients without as a control group)...
April 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29900143/long-chain-n-3-fatty-acids-improve-depression-syndrome-in-type-2-diabetes-mellitus
#11
Maryam Mazaherioun, Ahmad Saedisomeolia, Mohammad Hassan Javanbakht, Fariba Koohdani, Mahnaz Zarei, Samaneh Ansari, Fatemeh Khoshkhoo Bazargani, Mahmoud Djalali
Background: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms. Methods: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted...
April 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29900131/the-prevalence-of-metabolic-syndrome-in-iran-a-systematic-review-and-meta-analysis
#12
REVIEW
Saeideh Mazloomzadeh, Zahra Rashidi Khazaghi, Nouraddin Mousavinasab
Background: Metabolic syndrome (MS) is a collection of metabolic disorders which leads to early cardiovascular disease and diabetes type II. Regarding the wide range of its prevalence in Iran, this systematic review and meta-analysis determined the overall prevalence of the metabolic syndrome in Iran. Methods: In this systematic review and meta-analysis, the Medline, ISI, IranMedex, and SID were searched using "metabolic syndrome", "syndrome X", "prevalence", and "Iran" keywords from 2002 to 2012...
April 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29898754/metformin-inhibits-stromal-aromatase-expression-and-tumor-progression-in-a-rodent-model-of-postmenopausal-breast-cancer
#13
Erin D Giles, Sonali Jindal, Elizabeth A Wellberg, Troy Schedin, Steven M Anderson, Ann D Thor, Dean P Edwards, Paul S MacLean, Pepper Schedin
BACKGROUND: Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast cancer risk, a greater pathologic complete response to neoadjuvant therapy, and improved breast cancer survival. We hypothesized that metformin may be especially effective when targeted to the menopausal transition, as this is a lifecycle window when weight gain and metabolic syndrome increase, and is also when the risk for obesity-related breast cancer increases...
June 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29898634/meta-analysis-of-the-effects-of-exercise-training-on-markers-of-metabolic-syndrome-in-solid-organ-transplant-recipients
#14
Caixia Li, Jianming Xu, Wei Qin, Yan Hu, Huijuan Lu
BACKGROUND: The markers of metabolic syndrome can prompt the development of metabolic syndrome and are associated with worse graft function among transplant recipients. Studies have shown that exercise might be effective in reducing incidence rate of metabolic syndrome components in nontransplant patients. However, there is no sufficient evidence to determine whether exercise training is safe or effective for markers of metabolic syndrome among solid organ transplant recipients. OBJECTIVE: To evaluate the safety and efficacy of exercise training programs for risk markers of metabolic syndrome and to further evaluate its long-term effects in solid organ transplant recipients...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29898045/prevalence-and-factors-associated-with-metabolic-syndrome-among-brazilian-adult-population-national-health-survey-2013
#15
Elyssia Karine Nunes Mendonça Ramires, Risia Cristina Egito de Menezes, Giovana Longo-Silva, Taíse Gama Dos Santos, Patrícia de Menezes Marinho, Jonas Augusto Cardoso da Silveira
BACKGROUND: In Brazil, population-based researches analyzing prevalence and factors associated with metabolic syndrome (MS), a recognized predictor of cardiovascular diseases (CVD), and an important cause of disability and death in the country are scarce. OBJECTIVE: To evaluate prevalence of MS and its associated factors in Brazilian population. METHODS: Secondary analysis of the 2013 National Health Survey, a cross-sectional survey with national representativeness of Brazilian adult population (n = 59,402)...
May 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29895440/exploratory-lipidomics-in-patients-with-nascent-metabolic-syndrome
#16
Neeraj Ramakrishanan, Travis Denna, Sridevi Devaraj, Beverley Adams-Huet, Ishwarlal Jialal
BACKGROUND: Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potential to shed more light on the pathogenesis of MetS. OBJECTIVE: The aim of this study was to explore the lipidome in an unbiased fashion in patients with nascent MetS uncomplicated by diabetes and CVD...
May 25, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29895010/metabolic-syndrome-in-thyroid-disease
#17
K Alexander Iwen, Rebecca Oelkrug, Hannes Kalscheuer, Georg Brabant
Cardiometabolic risk factors like abdominal obesity, hyperglycemia, low high-density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension are defined as metabolic syndrome (MetS), which represents one of the most frequent endocrine disorders particularly in a society with increasing weight problems. As more and more evidence is accumulated that thyroid hormones affect components of the MetS, the present review aims to summarize the rapidly expanding knowledge on the pathophysiological interaction between thyroid hormone status and MetS...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29895006/the-metabolic-syndrome-in-central-hypogonadotrophic-hypogonadism
#18
Andrew A Dwyer, Richard Quinton
The metabolic syndrome (MetS) is a term used to describe the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, non-alcoholic fatty liver disease and arterial hypertension. Notably, a number of studies have shown high rates of testosterone (T) deficiency in men with MetS and type 2 diabetes mellitus (T2DM). Both hypogonadism and MetS confer increased health risk for morbidity and mortality as men with the MetS are at twice the risk for developing cardiovascular disease and at 5-fold higher risk for developing T2DM...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894997/metabolic-syndrome-in-hyperprolactinemia
#19
Marianne Andersen, Dorte Glintborg
The metabolic syndrome (MetS) is a conglomerate of clinical findings that convey into increased morbidity and mortality from type 2 diabetes mellitus (T2D) and cardiovascular disease. Hyperprolactinemia (hyperPRL) is associated with components of MetS, especially during pregnancy. Endogenous levels of sex steroids are high during pregnancy in contrast to untreated or replaced hypogonadism in most patients with a prolactinoma and hypogonadism may confer increased risk of MetS in hyperPRL. Dopamine-D2-agonist therapy can improve MetS in patients with a prolactinoma and lower glucose levels in patients with T2D...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894990/metabolic-syndrome-in-polycystic-ovary-syndrome
#20
Renato Pasquali
Both prevalence and incidence of the metabolic syndrome is very high in women with polycystic ovary syndrome (PCOS). Obesity and visceral fat enlargement play a dominant role in determining the final phenotype of PCOS. Androgen excess and insulin resistance may be responsible for the development of all features of the metabolic syndrome. The major factors responsible for this association seem to be related to a triumvirate including androgen excess, insulin resistance and associated hyperinsulinemia, and obesity, particularly the abdominal-visceral phenotype...
2018: Frontiers of Hormone Research
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