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https://www.readbyqxmd.com/read/28328031/post-traumatic-stress-disorder-and-antepartum-complications-a-novel-risk-factor-for-gestational-diabetes-and-preeclampsia
#1
Jonathan G Shaw, Steven M Asch, Jodie G Katon, Kate A Shaw, Rachel Kimerling, Susan M Frayne, Ciaran S Phibbs
BACKGROUND: Prior work shows that Post-traumatic Stress Disorder (PTSD) predicts an increased risk of preterm birth, but the causal pathway(s) are uncertain. We evaluate the associations between PTSD and antepartum complications to explore how PTSD's pathophysiology impacts pregnancy. METHODS: This retrospective cohort analysis of all Veterans Health Administration (VA)-covered deliveries from 2000-12 used the data of VA clinical and administration. Mothers with current PTSD were identified using the ICD-9 diagnostic codes (i...
March 22, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28327894/statistical-controversies-in-clinical-research-overlap-and-errors-in-the-meta-analyses-of-microrna-genetic-association-studies-in-cancers
#2
J H Park, M Eisenhut, H J Vliet, J I Shin
Background: : Various errors in the design, conduct, and analysis of medical and public health research studies can produce false results and waste valuable resources. While systematic reviews and meta-analyses are arguably considered the most dependable source of evidence-based medicine, increasing numbers of studies are indicating that, on the contrary to the public's belief, many of these investigations are redundant, erroneous, and even biased. Methods: 94 meta-analyses on microRNA polymorphism and risk of cancer were extracted from Pubmed database on August 2016...
January 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327545/calibration-free-assays-on-standard-real-time-pcr-devices
#3
Pawel R Debski, Kamil Gewartowski, Seweryn Bajer, Piotr Garstecki
Quantitative Polymerase Chain Reaction (qPCR) is one of central techniques in molecular biology and important tool in medical diagnostics. While being a golden standard qPCR techniques depend on reference measurements and are susceptible to large errors caused by even small changes of reaction efficiency or conditions that are typically not marked by decreased precision. Digital PCR (dPCR) technologies should alleviate the need for calibration by providing absolute quantitation using binary (yes/no) signals from partitions provided that the basic assumption of amplification a single target molecule into a positive signal is met...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327202/patients-perspective-of-disease-and-medication-adherence-for-type-2-diabetes-in-an-urban-area-in-bangladesh-a-qualitative-study
#4
Sheikh Mohammed Shariful Islam, Tuhin Biswas, Faiz A Bhuiyan, Kamrun Mustafa, Anwar Islam
BACKGROUND: Patients' perspective of diabetes and adherence to its prescribed medications is a significant predictor of glycemic control and overall management of the disease. However, there is a paucity of such information in Bangladesh. This study aimed to explore patients' perspective of diabetes, their experience of taking oral hypoglycemic medications and explore factors that contribute to medication adherence in patients with type 2 diabetes in Bangladesh. METHODS: We conducted in-depth face-to-face interviews with 12 type 2 diabetes patients attending a tertiary hospital in Dhaka city between February and March, 2014...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28326795/digital-health-care-by-in-silico-glycation-of-hba1-blood-cells
#5
James M Minor, Leslie M Rickey, Richard M Bergenstal
BACKGROUND: Diabetes health care relies on the HbA1c (A1c) assay and associated average glucose (AG) to evaluate and control chronic glycemia. However, the A1c assay is plagued with significant noise, lag time, and specificity issues. Current studies support the significant health care advantage of clinical action based on real-time blood glucose (BG) metrics. We seek to improve diabetes management by directly relating such metrics to AG levels as mediated by recently discovered recurrent endocrine cycles...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28325441/a-review-of-fuzzy-cognitive-maps-in-medicine-taxonomy-methods-and-applications
#6
REVIEW
Abdollah Amirkhani, Elpiniki I Papageorgiou, Akram Mohseni, Mohammad R Mosavi
BACKGROUND AND OBJECTIVE: A high percentage of medical errors, committed because of physician's lack of experience, huge volume of data to be analyzed, and inaccessibility to medical records of previous patients, can be reduced using computer-aided techniques. Therefore, designing more efficient medical decision-support systems (MDSSs) to assist physicians in decision-making is crucially important. Through combining the properties of fuzzy logic and neural networks, fuzzy cognitive maps (FCMs) are among the latest, most efficient, and strongest artificial intelligence techniques for modeling complex systems...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28325023/an-affordable-cuff-less-blood-pressure-estimation-solution
#7
Monika Jain, Niranjan Kumar, Sujay Deb
This paper presents a cuff-less hypertension pre-screening device that non-invasively monitors the Blood Pressure (BP) and Heart Rate (HR) continuously. The proposed device simultaneously records two clinically significant and highly correlated biomedical signals, viz., Electrocardiogram (ECG) and Photoplethysmogram (PPG). The device provides a common data acquisition platform that can interface with PC/laptop, Smart phone/tablet and Raspberry-pi etc. The hardware stores and processes the recorded ECG and PPG in order to extract the real-time BP and HR using kernel regression approach...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323607/language-based-inequity-in-health-care-who-is-the-poor-historian
#8
Alexander R Green, Chijioke Nze
Patients with limited English proficiency (LEP) are among the most vulnerable populations. They experience high rates of medical errors with worse clinical outcomes than English-proficient patients and receive lower quality of care by other metrics. However, we have yet to take the issue of linguistic inequities seriously in the medical system and in medical education, tacitly accepting that substandard care is either unavoidable or not worth the cost to address. We argue that we have a moral imperative to provide high-quality care to patients with LEP and to teach our medical trainees that such care is both expected and feasible...
March 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28321300/identifying-highlighting-and-reducing-polypharmacy-in-a-uk-hospice-inpatient-unit-using-improvement-science-methods
#9
Alison Phippen, Jennie Pickard, Douglas Steinke, Matt Cope, Dai Roberts
Polypharmacy, the concurrent use of multiple medications by one individual is a growing global issue driven by an ageing population and increasing prevalence of multi-morbidity[1]. Polypharmacy can be problematic: interactions between medications, reduced adherence to medication, burden of medication to patients, administration time, increased risk of errors and increased cost. Quality improvement methods were applied to identify and highlight polypharmacy patients with the aim of reducing their average number of regular tablets/capsules per day by 25%...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28321134/ismp-medication-error-report-analysis
#10
Michael R Cohen, Judy L Smetzer
These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your news-letters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program...
February 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28321014/homogeneous-assays-for-ldl-c-and-hdl-c-are-reliable-in-both-the-postprandial-and-fasting-state
#11
Takashi Miida, Kunihiro Nishimura, Satoshi Hirayama, Yoshihiro Miyamoto, Masakazu Nakamura, Daisaku Masuda, Shizuya Yamashita, Masaji Ushiyama, Toshiaki Komori, Naohisa Fujita, Shinji Yokoyama, Tamio Teramoto
AIM: Most epidemiological and clinical studies calculated low-density lipoprotein-cholesterol (LDL-C) by Friedewald's formula which cannot be used in the postprandial samples. Although the homogeneous assays with poor analytical performance were withdrawn from the market, it remained unclear whether the currently available reagents for LDL-C and high-density lipoprotein-cholesterol (HDL-C) are as accurate for postprandial samples as for fasting samples. METHODS: Fresh blood samples were collected from 59 non-diseased and 109 diseased subjects...
March 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28320691/microsoft-kinect-based-continuous-performance-test-an-objective-attention-deficit-hyperactivity-disorder-assessment
#12
David Delgado-Gomez, Inmaculada Peñuelas-Calvo, Antonio Eduardo Masó-Besga, Silvia Vallejo-Oñate, Itziar Baltasar Tello, Elsa Arrua Duarte, María Constanza Vera Varela, Juan Carballo, Enrique Baca-García
BACKGROUND: One of the major challenges in mental medical care is finding out new instruments for an accurate and objective evaluation of the attention deficit hyperactivity disorder (ADHD). Early ADHD identification, severity assessment, and prompt treatment are essential to avoid the negative effects associated with this mental condition. OBJECTIVE: The aim of our study was to develop a novel ADHD assessment instrument based on Microsoft Kinect, which identifies ADHD cardinal symptoms in order to provide a more accurate evaluation...
March 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28319551/a-contemporary-medicolegal-analysis-of-implanted-devices-for-chronic-pain-management
#13
Christopher R Abrecht, Penny Greenberg, Ellen Song, Richard D Urman, James P Rathmell
BACKGROUND: Analysis of closed malpractice claims allows the study of rare but serious complications and likely results in improved patient safety by raising awareness of such complications. Clinical studies and closed claims analyses have previously reported on the common complications associated with intrathecal drug delivery systems (IDDS) and spinal cord stimulators (SCS). This study provides a contemporary analysis of claims from within the past 10 years. METHODS: We performed a closed claims analysis for a period January 1, 2009 to December 31, 2013 for cases with pain medicine as the primary service...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28319042/smartphone-application-for-mechanical-quality-assurance-of-medical-linear-accelerator
#14
Hwiyoung Kim, Hyunseok Lee, Jong In Park, Chang Heon Choi, So-Yeon Park, Hee Jung Kim, Young Suk Kim, Sung-Joon Ye
Mechanical quality assurance (QA) of medical linear accelerators consists of time consuming and human-error prone procedures. We developed a smartphone-application system for mechanical QA. The system consists of two smartphones; one attached to the gantry to obtain real-time information on mechanical parameters of medical linear accelerator, and the other to display the real-time information by bluetoothing the former. Motion sensors embedded in the smartphone were used to measure gantry and collimator rotations...
March 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28318834/medical-errors-and-patient-safety-in-ophthalmology
#15
J J González-López, P Hernández-Martínez, F J Muñoz-Negrete
No abstract text is available yet for this article.
March 16, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28318505/machine-learning-in-the-prediction-of-cardiac-epicardial-and-mediastinal-fat-volumes
#16
É O Rodrigues, V H A Pinheiro, P Liatsis, A Conci
We propose a methodology to predict the cardiac epicardial and mediastinal fat volumes in computed tomography images using regression algorithms. The obtained results indicate that it is feasible to predict these fats with a high degree of correlation, thus alleviating the requirement for manual or automatic segmentation of both fat volumes. Instead, segmenting just one of them suffices, while the volume of the other may be predicted fairly precisely. The correlation coefficient obtained by the Rotation Forest algorithm using MLP Regressor for predicting the mediastinal fat based on the epicardial fat was 0...
February 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28316887/comparison-of-methods-of-alert-acknowledgement-by-critical-care-clinicians-in-the-icu-setting
#17
Andrew M Harrison, Charat Thongprayoon, Christopher A Aakre, Jack Y Jeng, Mikhail A Dziadzko, Ognjen Gajic, Brian W Pickering, Vitaly Herasevich
BACKGROUND: Electronic Health Record (EHR)-based sepsis alert systems have failed to demonstrate improvements in clinically meaningful endpoints. However, the effect of implementation barriers on the success of new sepsis alert systems is rarely explored. OBJECTIVE: To test the hypothesis time to severe sepsis alert acknowledgement by critical care clinicians in the ICU setting would be reduced using an EHR-based alert acknowledgement system compared to a text paging-based system...
2017: PeerJ
https://www.readbyqxmd.com/read/28314101/a-dielectrophoresis-system-for-testing-antimicrobial-susceptibility-of-gram-negative-bacteria-to-beta-lactam-antibiotics
#18
I-Hsiu Su, Wen-Chien Ko, Chung-Hsin Shih, Fang-Hao Yeh, Yung-Nien Sun, Jung-Chih Chen, Po-Lin Chen, Hsien-Chang Chang
Gram-negative bacteria (GNBs) are common pathogens causing severe sepsis. Rapid evaluation of drug susceptibility would guide effective antibiotic treatment, and promote life-saving. A total of 78 clinical isolates of 13 gram-negative species collected between April 2013 and November 2013 from two medical centers in Tainan were tested. Bacterial morphology changes in different concentrations of antibiotics were observed under the electric field of a quadruple electrode array using light microscopy. The minimal inhibitory concentrations (MICs) of four antimicrobial agents, namely cefazolin, ceftazidime, cefepime, and doripenem, were determined by the dielectrophoretic antimicrobial susceptibility testing (dAST) and by the conventional broth dilution testing (BDT)...
March 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28306610/30-day-potentially-avoidable-readmissions-due-to-adverse-drug-events
#19
Olivia Dalleur, Patrick E Beeler, Jeffrey L Schnipper, Jacques Donzé
OBJECTIVE: To analyze the patterns of potentially avoidable readmissions due to adverse drug events (ADEs) to identify the most appropriate risk reduction interventions. METHODS: In this observational study, we analyzed a random sample of 534 potentially avoidable 30-day readmissions from 10,275 consecutive discharges from the medical department of an academic hospital. Readmissions due to ADEs were reviewed to identify the causative drugs and the severity and interventions to prevent them...
March 17, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28306589/older-adult-kidney-function-assessment-and-rounding-creatinine-led-to-medication-dosing-error
#20
Timothy Nguyen, Yanique Foster, Shpres Cekaj
BACKGROUND/AREAS OF UNCERTAINTY: Kidney function assessment in older adults can be unreliable because of many factors, and inaccurate assessment can lead to medication dosing error. Practitioners may have adopted the method of rounding creatinine to an arbitrary number 1.0 because of change in muscle mass and age-related change. This has in fact proven to cause more harm than good, potentially leading to underdosing of many medications. DATA SOURCES: A literature search performed using PubMed with the following key words (rounding serum creatinine, rounding serum creatinine AND pharmacist or pharmacy, rounding serum creatinine AND doctor or physician or healthcare, rounding serum creatinine AND kidney function) with no restrictions (dates or any other requirement)...
March 1, 2017: American Journal of Therapeutics
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