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Fish oil and inflammation

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https://www.readbyqxmd.com/read/27916361/oral-omega-3-fatty-acids-promote-resolution-in-chemical-peritonitis
#1
Alexander C Chacon, Brett E Phillips, Miranda A Chacon, Deborah Brunke-Reese, Shannon L Kelleher, David I Soybel
BACKGROUND: Recent studies suggest that purified omega-3 fatty acids may attenuate acute inflammation and hasten the transition to healing. In this study, we tested the hypothesis that pretreatment with omega-3-rich fish oil (FO) would promote resolution of peritoneal inflammation through production of specific lipid mediators. METHODS: C57/BL6 mice were given a daily 200-μL oral gavage of saline (CTL) or FO (1.0-1.5 g/kg/d docosahexaenoic acid and 1.3-2.0 g/kg/d eicosapentaenoic acid) for 7 d before chemical peritonitis was induced with thioglycollate...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27902774/intravenous-treatment-with-a-long-chain-omega-3-lipid-emulsion-provides-neuroprotection-in-a-murine-model-of-ischemic-stroke-a-pilot-study
#2
Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P Eckert
Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Omegaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subjected to 90 minutes of MCAO...
2016: PloS One
https://www.readbyqxmd.com/read/27898676/dietary-butyrate-helps-to-restore-the-intestinal-status-of-a-marine-teleost-sparus-aurata-fed-extreme-diets-low-in-fish-meal-and-fish-oil
#3
Itziar Estensoro, Gabriel Ballester-Lozano, Laura Benedito-Palos, Fabian Grammes, Juan Antonio Martos-Sitcha, Liv-Torunn Mydland, Josep Alvar Calduch-Giner, Juan Fuentes, Vasileios Karalazos, Álvaro Ortiz, Margareth Øverland, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánchez
There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period...
2016: PloS One
https://www.readbyqxmd.com/read/27847435/evaluation-of-fish-oil-rich-in-mufas-for-anti-diabetic-and-anti-inflammation-potential-in-experimental-type-2-diabetic-rats
#4
Waranya Keapai, Sopida Apichai, Doungporn Amornlerdpison, Narissara Lailerd
The advantages of monounsaturated fatty acids (MUFAs) on insulin resistance and type 2 diabetes mellitus (T2DM) have been well established. However, the molecular mechanisms of the anti-diabetic action of MUFAs remain unclear. This study examined the anti-hyperglycemic effect and explored the molecular mechanisms involved in the actions of fish oil- rich in MUFAs that had been acquired from hybrid catfish (Pangasius larnaudii×Pangasianodon hypophthalmus) among experimental type 2 diabetic rats. Diabetic rats that were fed with fish oil (500 and 1,000 mg/kg BW) for 12 weeks significantly reduced the fasting plasma glucose levels without increasing the plasma insulin levels...
November 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27816052/postprandial-serum-endotoxin-in-healthy-humans-is-modulated-by-dietary-fat-in-a-randomized-controlled-cross-over-study
#5
Joshua M Lyte, Nicholas K Gabler, James H Hollis
BACKGROUND: High-fat diets may contribute to metabolic disease via postprandial changes in serum endotoxin and inflammation. It is unclear how dietary fat composition may alter these parameters. We hypothesized that a meal rich in n-3 (ω3) fatty acids would reduce endotoxemia and associated inflammation but a saturated or n-6 (ω6) fatty acid-rich meal would increase postprandial serum endotoxin concentrations and systemic inflammation in healthy adults. METHODS: Healthy adults (n = 20; mean age 25 ± 3...
November 5, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27815837/fish-oil-prevents-lipopolysaccharide-induced-depressive-like-behavior-by-inhibiting-neuroinflammation
#6
Zhe Shi, Huixia Ren, Zhijian Huang, Yu Peng, Baixuan He, Xiaoli Yao, Ti-Fei Yuan, Huanxing Su
Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas...
November 4, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27811230/in-vivo-activation-of-leukocyte-gpr120-ffar4-by-polyunsaturated-fatty-acids-has-minimal-impact-on-atherosclerosis-in-ldl-receptor-knockout-mice
#7
Swapnil V Shewale, Amanda L Brown, Xin Bi, Elena Boudyguina, Janet K Sawyer, Martha A Alexander-Miller, John S Parks
G protein-coupled receptor 120 (GPR120/FFAR4) activation by n-3 PUFAs attenuates inflammation, but its impact on atherosclerosis is unknown. We determined whether in vivo activation of leukocyte GPR120/FFAR4 by n-3 vs. n-6 PUFA is atheroprotective. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation. Mice were fed one of the four atherogenic diets containing 0.2% cholesterol and 10% calories as palm oil (PO) + 10% calories as: 1) PO, 2) fish oil (FO; 20:5 n-3 and 22:6 n-3 enriched), 3) echium oil (EO; 18:4 n-3 enriched), or 4) borage oil (BO; 18:3 n-6 enriched) for 16 weeks...
November 3, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27785012/docosahexaenoic-acid-liposomes-for-targeting-chronic-inflammatory-diseases-and-cancer-an-in-vitro-assessment
#8
Amr Alaarg, Nan Yeun Jordan, Johan Jf Verhoef, Josbert M Metselaar, Gert Storm, Robbert J Kok
Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and cancer. ω3 polyunsaturated fatty acids (PUFAs; also known as omega3 fatty acids or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these effects cannot be fully exploited unless diets are enriched with high concentrations of fish oil supplements over long periods of time. Here, a nanomedicine-based approach is presented for delivering effective levels of PUFAs to inflammatory cells...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27716366/the-effect-of-n-3-n-6-polyunsaturated-fatty-acids-on-acute-reflux-esophagitis-in-rats
#9
Ze-Hao Zhuang, Jing-Jing Xie, Jing-Jing Wei, Du-Peng Tang, Li-Yong Yang
BACKGROUND: Polyunsaturated fatty acids (PUFAs) play various roles in inflammation. However, the effect of PUFAs in the development of reflux esophagitis (RE) is unclear. This study is to investigate the potential effect of n-3/n-6 PUFAs on acute RE in rats along with the underlying protective mechanisms. METHODS: Forty Sprague Dawley rats were randomly divided into four groups (n = 10 in each group). RE model was established by pyloric clip and section ligation...
October 4, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27713004/biological-and-pathophysiological-roles-of-end-products-of-dha-oxidation
#10
Valentin P Yakubenko, Tatiana V Byzova
BACKGROUND: Polyunsaturated fatty acids (PUFA) are known to be present and/or enriched in vegetable and fish oils. Among fatty acids, n-3 PUFA are generally considered to be protective in inflammation-related diseases. The guidelines for substituting saturated fatty acids for PUFAs have been highly publicized for decades by numerous health organizations. Recently, however, the beneficial properties of n-3 PUFA are questioned by detailed analyses of multiple randomized controlled clinical trials...
October 3, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27708849/highly-purified-eicosapentaenoic-acid-ameliorates-cardiac-injury-and-adipose-tissue-inflammation-in-a-rat-model-of-metabolic-syndrome
#11
S Ito, Y Sano, K Nagasawa, N Matsuura, Y Yamada, A Uchinaka, T Murohara, K Nagata
INTRODUCTION: n-3 Polyunsaturated fatty acids such as eicosapentaenoic acid (EPA), which are abundant in fish oil, have been shown to delay the onset of cardiovascular events. We previously established DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, which are derived from a cross between Dahl salt-sensitive and Zucker rats, as a model of metabolic syndrome. This study has now explored the influence of highly purified EPA on cardiac and adipose tissue pathophysiology in this animal model. MATERIALS AND METHODS: DS/obese rats were administered EPA (300 or 1,000 mg kg(-1) d(-1), per os) or vehicle from age 9 to 13 weeks...
September 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27669173/dietary-enrichment-with-20-fish-oil-decreases-mucus-production-and-the-inflammatory-response-in-mice-with-ovalbumin-induced-allergic-lung-inflammation
#12
Jean A Hall, Jaye Hartman, Monica M Skinner, Adam R Schwindt, Kay A Fischer, William R Vorachek, Gerd Bobe, Beth A Valentine
The prevalence of asthma has increased in recent decades, which may be related to higher dietary intake of (n-6) polyunsaturated fatty acids (PUFA) and lower intake of (n-3) PUFA, e.g., those contained in fish oil. The objective of this study was to determine if dietary PUFA enrichment decreases mucus production or the inflammatory response associated with ovalbumin (OVA)-induced allergic lung inflammation. Mice (n = 10/group) were fed control, 20% fish oil, or 20% corn oil enriched diets for a total of 12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27637335/the-impact-of-an-omega-3-fatty-acid-rich-lipid-emulsion-on-fatty-acid-profiles-in-critically-ill-septic-patients
#13
Thomas C Hall, Dilraj K Bilku, Christopher P Neal, Jill Cooke, Helena L Fisk, Philip C Calder, Ashley R Dennison
BACKGROUND: Death from sepsis in the intensive therapy unit (ITU) is frequently preceded by the development of multiple organ failure as a result of uncontrolled inflammation. Treatment with omega-3 (n-3) fatty acids (FAs), principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been demonstrated to attenuate the effects of uncontrolled inflammation and may be clinically beneficial in reducing mortality from organ dysfunction. Fish oil (FO) is a source of EPA and DHA...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27633106/omega-3-polyunsaturated-fatty-acids-and-oxylipins-in-neuroinflammation-and-management-of-alzheimer-disease
#14
REVIEW
Jessay Gopuran Devassy, Shan Leng, Melissa Gabbs, Md Monirujjaman, Harold M Aukema
Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative conditions worldwide. Although the disease progression is becoming better understood, current medical interventions can only ameliorate some of the symptoms but cannot slow disease progression. Neuroinflammation plays an important role in the advancement of this disorder, and n-3 (ω-3) polyunsaturated fatty acids (PUFAs) are involved in both the reduction in and resolution of inflammation. These effects may be mediated by the anti-inflammatory and proresolving effects of bioactive lipid mediators (oxylipins) derived from n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in fish oil...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27620176/novel-fish-oil-based-bigel-system-for-controlled-drug-delivery-and-its-influence-on-immunomodulatory-activity-of-imiquimod-against-skin-cancer
#15
Khurram Rehman, Mohd Hanif Zulfakar
PURPOSE: To characterize bigel system as a topical drug delivery vehicle and to establish the immunomodulatory role of imiquimod-fish oil combination against skin cancer and inflammation resulting from chemical carcinogenesis. METHODS: Imiquimod-loaded fish oil bigel colloidal system was prepared using a blend of carbopol hydrogel and fish oil oleogel. Bigels were first characterized for their mechanical properties and compared to conventional gel systems. Ex vivo permeation studies were performed on murine skin to analyze the ability of the bigels to transport drug across skin and to predict the release mechanism via mathematical modelling...
September 12, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27564420/fish-oil-supplements-longevity-and-aging
#16
João Pedro de Magalhães, Michael Müller, G Ed Rainger, Wilma Steegenga
Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can increase lifespan, affecting pathways like inflammation and oxidation thought to be involved in the regulation of aging. Could fish oil and its omega-3 fatty acids act as geroprotectors? Probably not...
August 2016: Aging
https://www.readbyqxmd.com/read/27548217/evidence-to-support-the-anti-cancer-effect-of-olive-leaf-extract-and-future-directions
#17
REVIEW
Anna Boss, Karen S Bishop, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO...
2016: Nutrients
https://www.readbyqxmd.com/read/27546289/anti-inflammatory-effects-of-docosahexaenoic-acid-implications-for-its-cancer-chemopreventive-potential
#18
Hye-Won Yum, Hye-Kyung Na, Young-Joon Surh
The implication of inflammatory tissue damage in pathophysiology of human cancer as well as some metabolic disorders has been under intense investigation. Numerous studies have identified a series of critical signaling molecules involved in cellular responses to inflammatory stimuli. These include nuclear factor κB, peroxisome proliferator-activated receptor γ, nuclear factor erythroid 2 p45-related factor 2 and sterol regulatory element-binding protein 1. The proper regulation of these transcription factors mediating pro- and anti-inflammatory signaling hence provides an important strategy for the chemoprevention of inflammation-associated cancer...
October 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27516961/in-vivo-response-of-gsdma3-dfl-mice-to-topically-applied-fish-oil-effects-on-cellular-markers-and-macrophages
#19
Mohd Hanif Zulfakar, Rebecca M Porter, Charles M Heard
Psoriasis is an incurable autoimmune disease characterized by patches of abnormal red, itchy and scaly skin. This work examined the modulation of inflammation, hyperproliferation and immune cell markers following topical application of fish oil (FO) in comparison to the antipsoriatic agents, betamethasone dipropionate (BD) and salicylic acid (SA), to GsdmA3(Dfl)/+ mice, a hair loss mutant which also exhibits epidermal hyperproliferation akin to psoriasis. The mice were dosed with 100 mg of the test formulation and after 10 days, the mice were sacrificed, skin sections excised and subjected to immunohistochemical determination of COX-2, K17 and MAC-1; and immunofluorescence of Ki-67...
August 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27499372/adipocyte-in-vascular-wall-can-induce-the-rupture-of-abdominal-aortic-aneurysm
#20
Hirona Kugo, Nobuhiro Zaima, Hiroki Tanaka, Youhei Mouri, Kenichi Yanagimoto, Kohsuke Hayamizu, Keisuke Hashimoto, Takeshi Sasaki, Masaki Sano, Tatsuro Yata, Tetsumei Urano, Mitsutoshi Setou, Naoki Unno, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving the gradual dilation of the abdominal aorta. It has been reported that development of AAA is associated with inflammation of the vascular wall; however, the mechanism of AAA rupture is not fully understood. In this study, we investigated the mechanism underlying AAA rupture using a hypoperfusion-induced animal model. We found that the administration of triolein increased the AAA rupture rate in the animal model and that the number of adipocytes was increased in ruptured vascular walls compared to non-ruptured walls...
2016: Scientific Reports
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