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Fish oil and inflammation

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https://www.readbyqxmd.com/read/29679994/food-pyramid-for-subjects-with-chronic-pain-foods-and-dietary-constituents-as-anti-inflammatory-and-antioxidant-agents
#1
Mariangela Rondanelli, Milena Anna Faliva, Alessandra Miccono, Maurizio Naso, Mara Nichetti, Antonella Riva, Fabio Guerriero, Manuela De Gregori, Gabriella Peroni, Simone Perna
Emerging literature suggests that diet constituents may play a modulatory role in chronic pain (CP) through management of inflammation/oxidative stress, resulting in attenuation of pain. We performed a narrative review to evaluate the existing evidence regarding the optimum diet for the management of CP, and we built a food pyramid on this topic. The present review also describes the activities of various natural compounds contained in foods (i.e. phenolic compounds in extra-virgin olive oil (EVO)) listed on our pyramid, which have comparable effects to drug management therapy...
April 22, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29615288/cardiac-effects-of-fish-oil-in-a-rat-model-of-streptozotocin-induced-diabetes
#2
F Mayyas, R Jaradat, K H Alzoubi
BACKGROUND AND AIMS: Fish oil (FO) is rich in omega-3 polyunsaturated fatty acids, which have cardio-protective effects. This study aims to evaluate effects of FO in a rat model of streptozotocin (STZ) induced diabetes. METHODS AND RESULTS: Adults male Wistar rats were assigned to control (4 μl corn oil/g corn oil given by oral gavage), FO (4 μl Menhaden FO/g body weight given by oral gavage), diabetes (DM, 35 mg/kg STZ single intraperitoneal injection, corn oil), and DM + FO groups for 8 weeks...
February 25, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29599972/effects-of-fish-and-krill-oil-on-gene-expression-in-peripheral-blood-mononuclear-cells-and-circulating-markers-of-inflammation-a-randomised-controlled-trial
#3
Amanda Rundblad, Kirsten B Holven, Inge Bruheim, Mari C Myhrstad, Stine M Ulven
Marine n -3 (omega-3) fatty acids alter gene expression by regulating the activity of transcription factors. Krill oil is a source of marine n -3 fatty acids that has been shown to modulate gene expression in animal studies; however, the effect in humans is not known. Hence, we aimed to compare the effect of intake of krill oil, lean and fatty fish with a similar content of n -3 fatty acids, and high-oleic sunflower oil (HOSO) with added astaxanthin on the expression of genes involved in glucose and lipid metabolism and inflammation in peripheral blood mononuclear cells (PBMC) as well as circulating inflammatory markers...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29589997/rearing-zebrafish-on-black-soldier-fly-hermetia-illucens-biometric-histological-spectroscopic-biochemical-and-molecular-implications
#4
Arturo Vargas, Basilio Randazzo, Paola Riolo, Cristina Truzzi, Giorgia Gioacchini, Elisabetta Giorgini, Nino Loreto, Sara Ruschioni, Matteo Zarantoniello, Matteo Antonucci, Sara Polverini, Gloriana Cardinaletti, Simona Sabbatini, Francesca Tulli, Ike Olivotto
A desirable goal of the aquaculture sector is to replace most of fish meal and fish oil with more sustainable, cost-effective, and environmental friendly ingredients ensuring fish health and welfare standards. Due to minimal environmental impact, compared with most conventional feed commodities, insects deserve a growing attention as candidate ingredients for aquafeeds. The present study investigated, for the first time, the possible application of a 100% insect diet in zebrafish larval rearing. Through a multidisciplinary approach, the major biological responses of fish to the new diets were assessed...
March 28, 2018: Zebrafish
https://www.readbyqxmd.com/read/29580307/n-3-pufa-and-obesity-from-peripheral-tissues-to-the-central-nervous-system
#5
Aline Haas de Mello, Marcela Fornari Uberti, Bianca Xavier de Farias, Nathalia Alberti Ribas de Souza, Gislaine Tezza Rezin
The current paradigms of prevention and treatment are unable to curb obesity rates, which indicates the need to explore alternative therapeutic approaches. Obesity leads to several damages to the body and is an important risk factor for a number of other chronic diseases. Furthermore, despite the first alterations in obesity being observed and reported in peripheral tissues, studies indicate that obesity can also cause brain damage. Obesity leads to a chronic low-grade inflammatory state, and the therapeutic manipulation of inflammation can be explored...
March 27, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29566189/effects-of-n-3-long-chain-pufa-supplementation-to-lactating-mothers-and-their-breastfed-children-on-child-growth-and-morbidity-a-2-%C3%A3-2-factorial-randomized-controlled-trial-in-rural-ethiopia
#6
Alemayehu Argaw, Mekitie Wondafrash, Kimberley P Bouckaert, Patrick Kolsteren, Carl Lachat, Tefera Belachew, Bruno De Meulenaer, Lieven Huybregts
Background: Recurrent infections and inflammation contribute to growth faltering in low-income countries. n-3 (ω-3) Long-chain polyunsaturated fatty-acids (LC-PUFAs) may improve immune maturation, resistance to infections, and growth in young children who are at risk. Objective: We evaluated the independent and combined effects of fish oil (500 mg n-3 LC-PUFAs/d) supplementation to lactating mothers and their breastfed children, aged 6-24 mo, on child morbidity, systemic inflammation, and growth in southwest Ethiopia...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29512716/high-fish-oil-diet-promotes-liver-inflammation-and-activates-the-complement-system
#7
Huimin Jin, Cheng Yan, Tengfei Xiao, Nannan Yan, Jie Xu, Liping Zhou, Xiaoming Zhou, Qixiang Shao, Sheng Xia
Diets rich in n-3 polyunsaturated fatty acid (n-3 PUFA) fish oil (FO) have beneficial effects in obesity‑associated metabolic disease. However, contradictory roles in inflammatory disease intervention have been reported. Our previous work revealed that a high‑FO diet promoted myeloid cell differentiation by modifying the bone marrow microenvironment; however, its effects on liver inflammation and complement system activation remain unknown. By performing ELISA, reverse transcription‑quantitative polymerase chain reaction, flow cytometry and histology on mice fed with high‑FO and low‑fat diets, the present study demonstrated that a 4‑week high‑FO diet promoted liver inflammation in mice without affecting body or liver weight...
March 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29503145/statin-dose-reduction-with-complementary-diet-therapy-a-pilot-study-of-personalized-medicine
#8
Bianca Scolaro, Marina S Nogueira, Aline Paiva, Adriana Bertolami, Lucia P Barroso, Tomas Vaisar, Sean P Heffron, Edward A Fisher, Inar A Castro
OBJECTIVE: Statin intolerance, whether real or perceived, is a growing issue in clinical practice. Our aim was to evaluate the effects of reduced-dose statin therapy complemented with nutraceuticals. METHODS: First phase: Initially, 53 type 2 diabetic statin-treated patients received a supplementation with fish oil (1.7 g EPA + DHA/day), chocolate containing plant sterols (2.2 g/day), and green tea (two sachets/day) for 6 weeks. Second phase: "Good responders" to supplementation were identified after multivariate analysis (n = 10), and recruited for a pilot protocol of statin dose reduction...
February 20, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29494205/how-does-high-dha-fish-oil-affect-health-a-systematic-review-of-evidence
#9
Samaneh Ghasemi Fard, Fenglei Wang, Andrew J Sinclair, Glenn Elliott, Giovanni M Turchini
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content, have attracted much scientific attention in the last four decades. Fish oils that contain higher amounts of eicosapentaenoic acid (EPA; 20:5n-3) than docosahexaenoic acid (DHA; 22:6n-3), in a distinctive ratio of 18/12, are typically the most abundantly available and are commonly studied. Although the two fatty acids have traditionally been considered together, as though they were one entity, different physiological effects of EPA and DHA have recently been reported...
March 1, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29459508/hepatic-regeneration-and-reno-protection-by-fish-oil-nigella-sativa-oil-and-combined-fish-oil-nigella-sativa-volatiles-in-ccl-4-treated-rats
#10
Sahar Y Al-Okbi, Doha A Mohamed, Thanaa E Hamed, Amr E Edris, Karem Fouda
The aim of the present research was to investigate the effect of fish oil, crude Nigella sative oil and combined fish oil/Nigella sative volatile oil as hepato-regenerative and renal protective supplements. The oils were administered as emulsions to rat model with liver injury induced by CCl4 . Plasma activities of transaminases (AST and ALT) were evaluated as liver function indicators, while plasma creatinine and urea and creatinine clearance were determined as markers of kidney function. Plasma malondialdehyde (MDA), nitrite (NO) and tumor necrosis factor-α (TNF-α) were estimated to assess the exposure to oxidative stress and subsequent inflammation...
February 19, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29413488/marine-fish-oil-is-more-potent-than-plant-based-n-3-polyunsaturated-fatty-acids-in-the-prevention-of-mammary-tumors
#11
Jiajie Liu, Salma A Abdelmagid, Christopher J Pinelli, Jennifer M Monk, Danyelle M Liddle, Lyn M Hillyer, Barbora Hucik, Anjali Silva, Sanjeena Subedi, Geoffrey A Wood, Lindsay E Robinson, William J Muller, David W L Ma
Marine-derived n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to inhibit mammary carcinogenesis. However, evidence regarding plant-based α-linolenic acid (ALA), the major n-3 PUFA in the Western diet, remains equivocal. The objective of this study was to examine the effect of lifelong exposure to plant- or marine-derived n-3 PUFAs on pubertal mammary gland and tumor development in MMTV-neu(ndl)-YD5 mice. It is hypothesized that lifelong exposure to n-3 PUFA reduces terminal end buds during puberty leading to delayed tumor onset, volume and multiplicity...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29391271/eicosapentaenoic-acid-reduces-fecal-levels-of-calprotectin-and-prevents-relapse-in-patients-with-ulcerative-colitis
#12
Eleonora Scaioli, Alessandro Sartini, Matteo Bellanova, Massimo Campieri, Davide Festi, Franco Bazzoli, Andrea Belluzzi
BACKGROUND & AIMS: High fecal levels of calprotectin indicate mucosal inflammation and have been shown to predict relapse in patients with ulcerative colitis (UC). Eicosapentaenoic acid (EPA), the major component of n-3 fish oil, has anti-inflammatory properties in patients with chronic inflammatory disorders. We performed a placebo-controlled trial of patients with UC at risk of relapse to determine the ability of the free fatty acid form of EPA (EPA-FFA) to reduce intestinal inflammation, using fecal level of calprotectin as a marker...
January 31, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29385062/a-randomized-double-blinded-placebo-controlled-trial-investigating-the-effect-of-fish-oil-supplementation-on-gene-expression-related-to-insulin-action-blood-lipids-and-inflammation-in-gestational-diabetes-mellitus-fish-oil-supplementation-and-gestational-diabetes
#13
Mehri Jamilian, Mansooreh Samimi, Naghmeh Mirhosseini, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Mohsen Taghizadeh, Zatollah Asemi
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, and it is mostly associated with postpartum diabetes, insulin resistance, and dyslipidemia. Fish oil (omega-3) supplementation has been shown to reduce the risk of different chronic diseases such as cardiovascular disease, type 2 diabetes, and cancers, though the evidence of its impact on gestational diabetes is scarce. Our goal in this study was to determine the effect of fish oil administration on gene expression related to insulin action, blood lipids, and inflammation in women with GDM...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29382923/effect-of-a-fish-oil-based-lipid-emulsion-on-intestinal-failure-associated-liver-disease-in-children
#14
Tian Zhang, Nan Wang, Weihui Yan, Lina Lu, Yijing Tao, Fang Li, Ying Wang, Wei Cai
BACKGROUND/OBJECTIVES: The aim of this study was to assess the effects of a fish oil-based lipid emulsion on intestinal failure-associated liver disease (IFALD) in children. SUBJECTS/METHODS: From January 2014 through June 2017, we enrolled 32 children with IF on long-term parenteral nutrition (PN). When the levels of any three of seven liver indicators (TBA, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, gamma glutamyl transferase (γ-GT), total bilirubin (TB), or direct bilirubin (DB)) were two times higher than normal levels, we switched a 50:50 mix of soybean oil and medium-chain triglycerides (MCT) lipid emulsion (with an average dose of 1...
January 30, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29359480/the-effects-of-fish-oil-on-gene-expression-in-patients-with-polycystic-ovary-syndrome
#15
Elham Rahmani, Mehri Jamilian, Bahareh Dadpour, Zahra Nezami, Zahra Vahedpoor, Samaneh Mahmoodi, Esmat Aghadavod, Mohsen Taghizadeh, Abolfazl Beiki Hassan, Zatollah Asemi
BACKGROUND: This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, aged 18-40 years. Subjects were randomly allocated into two groups to take either 1000 mg omega-3 fatty acids from fish oil (n = 20) or placebo (n = 20) twice a day for 12 weeks...
March 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29343310/effect-of-dietary-fish-oil-on-selected-inflammatory-markers-in-pigs
#16
T Komprda, P Ondráčková, M Vícenová, V Rozíková, N Procházková, L Levá, M Faldyna
The present study tested a hypothesis that dietary fish oil (eicosapentaenoic acid+docosahexaenoic acid) in a commonly achievable dose ameliorates a systemic inflammation in pigs. Two groups of pigs of 16 animals each were fed a diet with either 2.5% of fish oil (F) or a control diet with 2.5% of palm oil (P). After 70 days of fattening, eight F and eight P pigs were challenged (F+; P+) i.v. by lipopolysaccharide. After 3 h, all pigs were sacrificed and blood, liver and visceral adipose tissue (VAT) samples were taken...
January 18, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29329427/ozone-induced-vascular-contractility-and-pulmonary-injury-are-differentially-impacted-by-diets-enriched-with-coconut-oil-fish-oil-and-olive-oil
#17
Samantha J Snow, Wan-Yun Cheng, Andres Henriquez, Myles Hodge, Virgina Bass, Gail M Nelson, Gleta Carswell, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Brian Chorley, Kymberly M Gowdy, Haiyan Tong, Urmila P Kodavanti
Fish, olive, and coconut oil dietary supplementation have several cardioprotective benefits, but it is not established if they protect against air pollution-induced adverse effects. We hypothesized that these dietary supplements would attenuate ozone-induced systemic and pulmonary effects. Male Wistar Kyoto rats were fed either a normal diet, or a diet supplemented with fish, olive, or coconut oil for 8 weeks. Animals were then exposed to air or ozone (0.8 ppm), 4h/day for 2 days. Ozone exposure increased phenylephrine-induced aortic vasocontraction, which was completely abolished in rats fed the fish oil diet...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29321047/effects-of-concentrated-long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-before-radical-prostatectomy-on-prostate-cancer-proliferation-inflammation-and-quality-of-life-study-protocol-for-a-phase-iib-randomized-double-blind-placebo-controlled-trial
#18
Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising intervention for prostate cancer patients. The aim of the study is to evaluate the effects of long-chain omega-3 polyunsaturated fatty acids (LCn3), more precisely eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation, on prostate cancer proliferation, inflammation mediators and quality of life among men who will undergo radical prostatectomy...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29249211/remodelling-of-primary-human-cd4-t-cell-plasma-membrane-order-by-n-3-pufa
#19
Yang-Yi Fan, Natividad R Fuentes, Tim Y Hou, Rola Barhoumi, Xian C Li, Nicolaas E P Deutz, Marielle P K J Engelen, David N McMurray, Robert S Chapkin
Cell membrane fatty acids influence fundamental properties of the plasma membrane, including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests that dietary n-3 PUFA may target the plasma membrane of immune cells by altering plasma membrane lipid dynamics, thereby regulating the attenuation of immune cell activation and suppression of inflammation. As lipid-based immunotherapy might be a promising new clinical strategy for the treatment of inflammatory disorders, we conducted in vitro and in vivo experiments to examine the effects of n-3 PUFA on CD4+ T cell membrane order, mitochondrial bioenergetics and lymphoproliferation...
January 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29237497/hyaluronic-acid-is-associated-with-organ-dysfunction-in-acute-respiratory-distress-syndrome
#20
Anthony J Esposito, Pavan K Bhatraju, Renee D Stapleton, Mark M Wurfel, Carmen Mikacenic
BACKGROUND: Hyaluronic acid (HA), an extracellular matrix component, is degraded in response to local tissue injury or stress. In various animal models of lung injury, HA has been shown to play a mechanistic role in modulating inflammation and injury. While HA is present in the lungs of patients with acute respiratory distress syndrome (ARDS), its relationship to patient outcomes is unknown. METHODS: We studied 86 patients with ARDS previously enrolled in the Phase II Randomized Trial of Fish Oil in Patients with Acute Lung Injury (NCT00351533) at five North American medical centers...
December 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
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