keyword
MENU ▼
Read by QxMD icon Read
search

Fish oil and inflammation

keyword
https://www.readbyqxmd.com/read/29209514/fish-oil-supplementation-in-chronic-obstructive-pulmonary-disease-feasibility-of-conducting-a-randomised-controlled-trial
#1
Ashley S Fulton, Alison M Coates, Marie T Williams, Peter R C Howe, Manohar L Garg, Lisa G Wood, Peter Frith, Alison M Hill
Background: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a randomised controlled trial of LCn-3PUFA supplementation in adults with COPD. Methods: A 16-week parallel, double-blind, randomised, placebo-controlled dietary supplementation trial was conducted...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29194424/functional-foods-and-lifestyle-approaches-for-diabetes-prevention-and-management
#2
REVIEW
Ahmad Alkhatib, Catherine Tsang, Ali Tiss, Theeshan Bahorun, Hossein Arefanian, Roula Barake, Abdelkrim Khadir, Jaakko Tuomilehto
Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular consumption of functional foods may be associated with enhanced anti-oxidant, anti-inflammatory, insulin sensitivity, and anti-cholesterol functions, which are considered integral to prevent and manage T2DM. Components of the Mediterranean diet (MD)-such as fruits, vegetables, oily fish, olive oil, and tree nuts-serve as a model for functional foods based on their natural contents of nutraceuticals, including polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, and unsaturated fatty acids...
December 1, 2017: Nutrients
https://www.readbyqxmd.com/read/29186929/integrated-immunomodulatory-mechanisms-through-which-long-chain-n-3-polyunsaturated-fatty-acids-attenuate-obese-adipose-tissue-dysfunction
#3
REVIEW
Danyelle M Liddle, Amber L Hutchinson, Hannah R Wellings, Krista A Power, Lindsay E Robinson, Jennifer M Monk
Obesity is a global health concern with rising prevalence that increases the risk of developing other chronic diseases. A causal link connecting overnutrition, the development of obesity and obesity-associated co-morbidities is visceral adipose tissue (AT) dysfunction, characterized by changes in the cellularity of various immune cell populations, altered production of inflammatory adipokines that sustain a chronic state of low-grade inflammation and, ultimately, dysregulated AT metabolic function. Therefore, dietary intervention strategies aimed to halt the progression of obese AT dysfunction through any of the aforementioned processes represent an important active area of research...
November 27, 2017: Nutrients
https://www.readbyqxmd.com/read/29142166/fish-oil-feeding-reverses-hepatomegaly-and-disrupted-hepatic-function-due-to-the-lack-of-fxr-signaling
#4
Masaaki Miyata, Kouhei Shinno, Tomoki Kinoshita, Yuichi Kinoshita, Yoshimasa Sugiura
Mice lacking farnesoid X receptor (FXR) are used as a model for nonalcoholic fatty liver disease because their livers exhibit hepatomegaly, hepatic steatosis, and hepatic inflammation. The influence of fish oil feeding on hepatomegaly and disrupted hepatic function was investigated using female Fxr-null mice and wild-type mice fed a fish oil diet (2% fish oil and 2% corn oil) or a control diet (4% corn oil) for 4 weeks. Hepatic n-3 polyunsaturated fatty acid (PUFA) levels, including 22:6 n-3 docosahexaenoic acid (DHA) and 20:5 n-3 eicosapentaenoic acid (EPA) were significantly higher in the fish oil group than those in the control group of Fxr-null mice and wild-type mice...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29109025/fish-oil-feeding-attenuates-neuroinflammatory-gene-expression-without-concomitant-changes-in-brain-eicosanoids-and-docosanoids-in-a-mouse-model-of-alzheimer-s-disease
#5
Kathryn E Hopperton, Marc-Olivier Trépanier, Nicholas C E James, Raphaël Chouinard-Watkins, Richard P Bazinet
BACKGROUND: Neuroinflammation is a recognized hallmark of Alzheimer's disease, along with accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 polyunsaturated fatty acids (PUFA) and molecules derived from them, including eicosapentaenoic acid-derived eicosanoids and docosahexaenoic acid-derived docosanoids, are known to have both anti-inflammatory and pro-resolving properties, while human observational data links consumption of these fatty acids to a decreased risk of Alzheimer's disease...
November 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29080699/therapeutic-potential-of-omega-3-fatty-acid-derived-epoxyeicosanoids-in-cardiovascular-and-inflammatory-diseases
#6
REVIEW
Wolf-Hagen Schunck, Anne Konkel, Robert Fischer, Karsten-Henrich Weylandt
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering, amelioration of inflammatory, and neurodegenerative disorders. This review covers recent findings indicating that a variety of these beneficial effects are mediated by "omega-3 epoxyeicosanoids", a class of novel n-3 LC-PUFA-derived lipid mediators, which are generated via the cytochrome P450 (CYP) epoxygenase pathway. CYP enzymes, previously identified as arachidonic acid (20:4n-6; AA) epoxygenases, accept eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA), the major fish oil n-3 LC-PUFAs, as efficient alternative substrates...
November 7, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29080687/a-comparative-study-difference-in-omega-6-omega-3-balance-and-saturated-fat-in-diets-for-atlantic-salmon-salmo-salar-affect-immune-fat-metabolism-oxidative-and-apoptotic-gene-expression-and-eicosanoid-secretion-in-head-kidney-leukocytes
#7
Elisabeth Holen, Pedro Araujo, Nini H Sissener, Grethe Rosenlund, Rune Waagbø
The aim of this study was to compare how different dietary vegetable oil n-6/n-3 ratios affect gene responses involved in inflammation, signaling pathways, fatty acid synthesis and oxidation, oxidation and apoptosis as well as eicosanoid production in salmon head kidney tissues and isolated head kidney leukocytes. Salmon smolts (200 g) were fed four different diets where the main lipid components were palm oil (n-6/n-3 ratio = 0.7), rapeseed oil (n-6/n-3 ratio = 0.9), and soybean oil (n-6/n-3 ratio = 2...
October 30, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29035816/docosahexaenoic-acid-attenuates-carbon-tetrachloride-induced-hepatic-fibrosis-in-rats
#8
Jianlin He, Kaikai Bai, Bihong Hong, Feng Zhang, Shizhong Zheng
Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health effects, including hepatoprotection. However, the effect of DHA alone has not been well studied, and the mechanism is not fully understood. In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl4) induced hepatic fibrosis. Compared with the control group, the CCl4 group showed hepatic damage as evidenced by histological changes and elevation in serum transaminase activity, fibrosis, inflammation and oxidative stress levels...
October 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29025396/a-description-of-the-gross-pathology-of-drowning-and-other-causes-of-mortality-in-seabirds
#9
Victor R Simpson, David N Fisher
BACKGROUND: Mortality of seabirds due to anthropogenic causes, especially entrapment in fishing gear, is a matter of increasing international concern. This study aimed at characterising the gross pathology of seabirds that drowned in fishing nets and comparing it with that in other common causes of mortality. RESULTS: Post-mortem examinations were performed on 103 common guillemots, 32 razorbills, 37 shags and 5 great northern divers found stranded in Cornwall during 1981-2016...
October 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28987035/the-psychoneuroimmunological-role-of-omega-3-polyunsaturated-fatty-acids-in-major-depressive-disorder-and-bipolar-disorder
#10
Ian Hunter Rutkofsky, Anser Saeed Khan, Sindhu Sahito, Vikram Kumar
Context • Psychoneuroimmunology is the interdisciplinary study that links behavioral health with the neuroendocrinal system and investigates that link's bidirectional impact on the human immune system. Mechanistic studies have shown how omega-3 polyunsaturated fatty acids (PUFAs), like those found in fish oil, can modulate key pathways involved in inflammation, sympathetic activity, oxidative stress, transcription factors, and inflammatory cytokine production. Objective • The research team intended to investigate the effects that PUFAs have on the brain and the immune system, including the effects of proinflammatory cytokines and oxidative stress, and their therapeutic benefits in major depressive disorder (MDD) and bipolar disorder, either as an alternative monotherapy or a complementary adjunct treatment...
July 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28900017/omega-3-fatty-acids-and-inflammatory-processes-from-molecules-to-man
#11
REVIEW
Philip C Calder
Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n-3) fatty acids and explain the roles of bioactive members of those fatty acid families in inflammatory processes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements...
October 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28893413/fish-oil-emulsion-supplementation-might-improve-quality-of-life-of-diabetic-patients-due-to-its-antioxidant-and-anti-inflammatory-properties
#12
Lucia Laubertová, Katarína Koňariková, Helena Gbelcová, Zdeňka Ďuračková, Jana Muchová, Iveta Garaiova, Ingrid Žitňanová
Diabetes-related complications, including cardiovascular disease, retinopathy, nephropathy, and neuropathy, are a significant cause of increased morbidity and mortality among people with diabetes. Previous studies have confirmed that hyperglycemia has pro-oxidative and proinflammatory properties which cause diabetic complications. We hypothesized that supplementation of fish oil emulsion (FOE), rich in omega-3 polyunsaturated fatty acids, to diabetic patients might reduce hyperglycemia-induced pathological changes due to specific properties of FOE...
August 3, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28887275/ffa4-gpr120-as-a-fatty-acid-sensor-involved-in-appetite-control-insulin-sensitivity-and-inflammation-regulation
#13
REVIEW
Dong-Soon Im
Unsaturated long-chain fatty acids have been suggested to be beneficial in the context of cardiovascular disorders based in epidemiologic studies conducted in Greenland and Mediterranean. DHA and EPA are omega-3 polyunsaturated fatty acids that are plentiful in fish oil, and oleic acid is an omega-9 monounsaturated fatty acid, rich in olive oil. Dietary intake of these unsaturated long-chain fatty acids have been associated with insulin sensitivity and weight loss, which contrasts with the impairment of insulin sensitivity and weight gain associated with high intakes of saturated long-chain fatty acids...
September 8, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28800645/analysis-of-endogenous-lipids-during-intestinal-wound-healing
#14
Yunna Lee, Jieun Choo, Su Jin Kim, Gwangbeom Heo, Charalabos Pothoulakis, Yong-Hak Kim, Eunok Im
Intestinal wound healing is a new therapeutic goal for inflammatory bowel disease (IBD) as complete healing of the mucosa is the key element of clinical remission in IBD. Previous studies showed that termination of inflammation can be achieved by adding pro-resolving lipids like DHA and EPA exogenously. However, the roles of these lipids in mucosal healing have not been investigated. To recapitulate intestinal healing process, mice were received dextran sodium sulfate (DSS) for 7 days in the drinking water followed by regular tap water for 5 additional days...
2017: PloS One
https://www.readbyqxmd.com/read/28792885/fish-oil-containing-lipid-emulsions-in-adult-parenteral-nutrition-a-review-of-the-evidence
#15
Osman Abbasoglu, Gil Hardy, William Manzanares, Alessandro Pontes-Arruda
BACKGROUND: There is evidence from laboratory and animal studies that fish oil-containing intravenous lipid emulsions (FOC-IVLEs) have a beneficial effect on inflammation and the immune response, suggesting a possible clinical benefit. Clinical studies of FOC-IVLEs have reported mixed results. The aim of this review is to present findings from recent randomized controlled clinical trials and other quality clinical studies investigating the effects of administering intravenous fish oil alone or as part of a multilipid emulsion and to examine the quality of these studies in an objective, evidence-based manner...
August 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28767202/effects-of-parenteral-fish-oil-on-plasma-nonesterified-fatty-acids-and-systemic-inflammatory-mediators-in-dogs-following-ovariohysterectomy
#16
Kaoru Tsuruta, Robert C Backus, Amy E DeClue, Kevin L Fritsche, Fred A Mann
OBJECTIVE: To evaluate the effects of intravenous (IV) infusion of fish oil (FO) emulsion following ovariohysterectomy (OVH) on inflammatory mediators and plasma omega-3 nonesterified fatty acids (NEFA) concentrations in dogs. DESIGN: Prospective clinical study. SETTING: University teaching hospital. ANIMALS: Twenty-nine privately owned dogs undergoing routine OVH. INTERVENTIONS: Postoperative 3-hour IV infusion of saline (n = 9), FO (Omegaven, n = 10), or soybean oil (SO, intralipid, n = 10) emulsion and blood collected before, 5 and 24 hours following OVH for plasma NEFA and RBC membrane fatty acids (FAs) concentrations, leukocyte cytokine production capacity, and C-reactive protein (CRP) measurement...
September 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28758717/epa%C3%A2-%C3%A2-dha-supplementation-reduces-pmn-activation-in-microenvironment-of-chronic-venous-leg-ulcers-a-randomized-double-blind-controlled-study
#17
Jodi C McDaniel, Laura Szalacha, Michelle Sales, Sashwati Roy, Scott Chafee, Narasimham Parinandi
Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN-derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth factors. The bioactive components of fish oil (n-3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong inflammation-resolving actions and have been shown to assuage PMN activity, but have not been tested in CVLU patients...
July 31, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28734043/enabling-reduction-of-low-grade-inflammation-in-seniors-pilot-study-concept-rationale-and-design
#18
RANDOMIZED CONTROLLED TRIAL
Todd M Manini, Stephen D Anton, Daniel P Beavers, Jane A Cauley, Mark A Espeland, Roger A Fielding, Stephen B Kritchevsky, Christiaan Leeuwenburgh, Kristina H Lewis, Christine Liu, Mary M McDermott, Michael E Miller, Russell P Tracy, Jeremy D Walston, Barbara Radziszewska, Jane Lu, Cindy Stowe, Samuel Wu, Anne B Newman, Walter T Ambrosius, Marco Pahor
OBJECTIVES: To test two interventions to reduce interleukin (IL)-6 levels, an indicator of low-grade chronic inflammation and an independent risk factor for impaired mobility and slow walking speed in older adults. DESIGN: The ENabling Reduction of low-Grade Inflammation in SEniors (ENRGISE) Pilot Study was a multicenter, double-blind, placebo-controlled randomized pilot trial of two interventions to reduce IL-6 levels. SETTING: Five university-based research centers...
September 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28729463/dietary-pufas-attenuate-nlrp3-inflammasome-activation-via-enhancing-macrophage-autophagy
#19
Lulu Shen, Yan Yang, Tiantong Ou, Chia-Chi C Key, Sarah H Tong, Russel C Sequeira, Jonathan M Nelson, Yan Nie, Zhan Wang, Elena Boudyguina, Swapnil V Shewale, Xuewei Zhu
Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood. We fed Ldlr(-/-) mice diets containing 10% (calories) palm oil (PO) and 0.2% cholesterol, supplemented with an additional 10% of calories as PO, fish oil (FO), echium oil (EO, containing 18:4 n-3), or borage oil (BO, containing 18:3 n-6). Inflammasome activation, autophagic flux, and mitochondrial function were measured in peritoneal macrophages, blood monocytes, or liver from diet-fed mice...
September 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28684736/fish-oil-enriched-nutrition-combined-with-systemic-chemotherapy-for-gastrointestinal-cancer-patients-with-cancer-cachexia
#20
Yumiko Shirai, Yoshinaga Okugawa, Asahi Hishida, Aki Ogawa, Kyoko Okamoto, Miki Shintani, Yuki Morimoto, Ryutaro Nishikawa, Takeshi Yokoe, Koji Tanaka, Hisashi Urata, Yuji Toiyama, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Donald C McMillan, Chikao Miki
Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy...
July 6, 2017: Scientific Reports
keyword
keyword
36166
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"