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Esomeprazole

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https://www.readbyqxmd.com/read/29327523/association-of-physicians-of-india-position-statement-on-role-of-chirally-pure-molecules-in-clinical-practice
#1
Milind Y Nadkar, Mangesh Tiwaskar, Sanjay Kalra, Siddharth N Shah, B R Bansode, Anjanlal Dutta, Sarita Bajaj, Sameer Aggarwal, Yatan Pal Singh Balhara, A K Das, Puneet Dhamija, Y K Gupta, Jubbin Jacob, Sundeep Mishra, S N Narasingan, C K Ponde, Ram Prabhoo, Balakrishnan S, Manisha Sahay, R K Sahay, I Sathyamurthy, Shilpa Tiwaskar, Agam Vora
Chirally pure molecules or enantiomers are non-superimposable mirror images of each other with a chiral center (such as carbon, sulphur, nitrogen or phosphorous atom). An equimolar mixture of enantiomers forms a racemate. Chirally pure molecules (single enantiomers) are important in the field of drug discovery as the drug targets such as enzymes and receptors are enantioselective in nature. Clinical studies have demonstrated that chirally pure drugs exhibit different pharmacokinetic and metabolic profiles, reduced adverse events, improved safety profiles and similar therapeutic activity at lowered drug dosage as compared with the racemate in many therapeutic areas...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29314277/erasmus-syndrome-associated-with-an-immune-thrombocytopenic-purpura
#2
Maxime Fouchard, Brigitte Pan Petesch, Claire Abasq-Thomas, Alain Saraux, Laurent Misery, Emilie Brenaut
We report the observation of a 57-year-old patient followed for an Erasmus syndrome (a systemic sclerosis developing secondary to silica exposure) (1) diagnosed in 2002 after being exposed as a dental technician, for whom a severe thrombocytopenia was discovered. He suffered from a pulmonary fibrosis, polyarthralgia, esophageal dysphagia and cutaneous involvement such as finger ulcerations and sclerodactylia. The treatment was made of nifedipine 30mg/day, esomeprazole 20mg/day and bosentan 25 mg twice a day...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29310119/efficacy-of-reduced-dosage-of-amoxicillin-in-an-eradication-therapy-for-helicobacter-pylori-infection-in-patients-on-hemodialysis-a-randomized-controlled-trial
#3
Shu Sahara, Mitsushige Sugimoto, Hitomi Ichikawa, Takuma Kagami, Yukitoshi Sakao, Naro Ohashi, Yoshiaki Horio, Ken Sugimoto, Akihiko Kato, Takahisa Furuta, Hideo Yasuda
BACKGROUND: An optimum Helicobacter pylori-eradication regimen for hemodialysis patients is yet to be established because of different pharmacokinetics of amoxicillin involved between hemodialysis patients and healthy subjects. We investigated to establish appropriate doses of amoxicillin for H. pylori infection eradication in hemodialysis patients. METHODS: Of 409 hemodialysis patients screened for H. pylori infection, 37 H. pylori-positive patients were randomized to different 1-week eradication regimens: esomeprazole 20 mg twice a day (b...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29307999/first-week-clinical-responses-to-dexlansoprazole-60-mg-and-esomeprazole-40-mg-for-the-treatment-of-grades-a-and-b-gastroesophageal-reflux-disease
#4
Chih-Ming Liang, Ming-Te Kuo, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsing-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu, Seng-Kee Chuah
AIM: To compare the one-week clinical effects of single doses of dexlansoprazole and esomeprazole on grades A and B erosive esophagitis. METHODS: We enrolled 175 adult patients with gastroesophageal reflux disease (GERD). The patients were randomized in a 1:1 ratio into two sequence groups to define the order in which they received single doses of dexlansoprazole (n = 88) and esomeprazole (n = 87) for an intention-to-treat analysis. The primary end-points were the complete symptom resolution (CSR) rates at days 1, 3, and 7 after drug administration...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29280391/development-of-a-new-esomeprazole-delayed-release-gastro-resistant-pellet-formulation-with-improved-storage-stability
#5
Panagiotis Barmpalexis, Agni Grypioti
The present study describes the development of a new esomeprazole (ESO) delayed release gastro-resistant formulation with improved storage stability. A three step (drug-, sub(seal)- and enteric-) coating process was employed with the aid of a fluid bed coater. Several formulation factors (namely size and quantity of starting non-pareil sugar spheres, binder quantity during drug-layering, sub(seal)-coating polymer type and quantity and enteric coating quantity) were evaluated and the whole process was modelled with the aid of feed-forward back-propagation artificial neural networks (ANNs)...
December 27, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29280047/an-evaluation-of-the-protective-effect-of-esomeprazole-in-an-experimental-model-of-renal-ischemia-reperfusion
#6
Tayyar Alp Ozkan, Nihat Karakoyunlu, Reyhan Polat, Gülistan Sanem Sarıbaş, Nevzat Can Şener, Seyda Özdemir, Kevser Peker, Dilek Ünal, Can Tuygun
PURPOSE: The ischemia and subsequent reperfusion (IR) which occurs in partial nephrectomy used in the treatment of renal tumors causes loss of parenchyma in the damaged kidney. The aim of this study is to evaluate, both biochemically and histologically, the efficacy of esomeprazole in an ischemia-reperfusion model in rat kidneys. METHODS: The rats were randomized into three groups of seven animals each, referred to as the sham, control, and PPI groups. In the sham group, only a laparotomy was performed...
December 26, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29260533/-effect-of-proton-pump-inhibitors-on-severe-acute-pancreatitis-a-prospective-randomized-trial
#7
Xiao Ma, Cheng-Wei Tang, Zhi-Yin Huang, Ming-Guang Zhang, Fang Liu, Chun-Hui Wang, Rui Wang, Huan Tong, Ling Liu
OBJECTIVE: To evaluate the effect of proton pump inhibitors (PPIs) therapy on severe acute pancreatitis (SAP) patients. METHODS: Forty five patients with SAP recruited in our center from October 2015 to October 2016,were randomly assigned into two groups: convention group (C group,n=21) and convention+esomeprazole group (C+E group,n=24). C+E group received esomeprazole 40 mg/d intravenously for 1 week,whereas C group only received baseline treatment. Serum C-reactive protein (CRP),interleukin-6 (IL-6) and interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) were detected by ELISA on the first day (baseline) and the seventh day...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29223273/a-79-year-old-woman-with-dyspnea-and-hypoxemia-that-worsened-in-an-upright-position
#8
Tjeerd van der Veer, Johannes C C M In 't Veen, Wijnand K den Dekker, Jelle Miedema
A 79-year-old woman presented to the ED with complaints of gradually worsening exertional dyspnea, dizziness, and chest discomfort. For several weeks she had not been able to perform light household work. The patient's medical history mentioned pulmonary embolism following immobilization (2012), several fractures after trauma, an ischemic cerebral vascular accident (2014), and curative treatment for breast cancer (1995). Her current medication included esomeprazole, clopidogrel, simvastatin, calcium/vitamin D, amitriptyline, and acetaminophen...
December 2017: Chest
https://www.readbyqxmd.com/read/29218061/a-comparative-study-of-efficacy-and-safety-of-two-eradication-regimens-for-helicobacter-pylori-infection
#9
Carmen Monica Preda, Doina Proca, Irina Sandra, Larisa Elena Fulger, Boroka Claudia Horeanga, Mircea Manuc, Teodora Manuc, Catalin Andrei Dutei, Mihaela Barbu, Letitia Tugui, Adriana-Corina Andrei, Bogdan Ionut Slavulete, Mircea Diculescu
Introduction: Helicobacter pylori infection is one of the most frequent diseases around the world, affecting about half of the world population. The infection is known to be associated with upper gastrointestinal diseases. The aim of this paper is to identify which of the following two first-line therapy options (ECA vs ECM - see abbreviations below) is more efficient and to assess the improvement in the quality of life among these patients. Material and Methods: 96 patients with proven Helicobacter pylori infection were divided in two treatment groups, as follows: 47 patients received a 10-day triple therapy with esomeprazole 80 mg/day, amoxicillin 2000 mg/day and clarithromycin 1000 mg/day (ECA) and the rest of 49 received a 10-day sequential therapy: esomeprazole 40 mg and amoxicillin 1000 mg twice daily for five days, followed by esomeprazole 40 mg, clarithromycin 500 mg and metronidazole 500 mg (ECM) twice daily for another five days...
September 2017: Mædica
https://www.readbyqxmd.com/read/29215618/is-double-dose-esomeprazole-with-bismuth-really-safe
#10
Angelo Zullo, Vincenzo De Francesco, Dino Vaira
No abstract text is available yet for this article.
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29195714/-gastric-acid-rebound-after-a-proton-pump-inhibitor-narrative-review-of-literature
#11
Michaël Rochoy, Sébastien Dubois, Raymond Glantenet, Sophie Gautier, Marc Lambert
BACKGROUND: Since the introduction of the first proton pump inhibitor (PPI) 20 years ago, studies have examined the presence of a rebound effect when this treatment is discontinued. These studies are heterogeneous and contradictory: the last literature review on the rebound in gastric acidity dates from 2006 and did not allow to conclude on the subject. Our objective was to carry out an up-to-date literature review on the existence and characteristics of this gastric acid rebound at the end of PPIs...
October 26, 2017: Thérapie
https://www.readbyqxmd.com/read/29186640/-esomeprazol-induced-cutaneous-lupus-erythematosus
#12
Nina Gliem, Sigrid Maria Caroline Broekaert, Cornelia Sabine Seitz, Michael P Schön, Volker Ellenrieder
Proton pump inhibitors are among the most commonly used drugs worldwide. They are considered to be largely safe and cause little side-effects. We report a 69-year-old woman who suffered from erythematous plaques 2 months after initiating therapy with esomeprazole. The diagnosis of subacute cutaneous lupus erythematosus was based on the clinical picture together with characteristic histological features of a skin biopsy specimen and the detection of anti-Ro/SSA antibodies. In particular, the temporal relationship with the onset of proton pump inhibitor therapy led to the high-level suspicion of a drug-induced pathogenesis...
September 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29180558/using-drug-prescribing-patterns-to-identify-stewards-of-cost-conscious-care
#13
Nicole Michele Gastala, Peter Wingrove, Winston Liaw, Stephen Petterson, Andrew Bazemore
PURPOSE: To characterize family physicians (FPs) who are stewards of care by consistently prescribing omeprazole over esomeprazole. METHODS: Cross-sectional analysis of physicians prescribing omeprazole or esomeprazole under Medicare Part D in 2014. RESULTS: There was a regional trend with 49% of Western FPs but only 6% of Southern FPs rarely prescribing esomeprazole. Physicians had increased odds of being a steward if they worked with a care coordinator (P < ...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29161792/-trend-in-the-eradication-rates-of-helicobacter-pylori-infection-over-the-last-10-years-in-west-gyeonggi-do-korea-a-single-center-experience
#14
Jong Seol Park, Ji Eun Park, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo, Jaehoon Jahng, Yong Sung Kim
Background/Aims: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. Methods: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29156525/esomeprazole-ameliorates-ccl4-induced-liver-fibrosis-in-rats-via-modulating-oxidative-stress-inflammatory-fibrogenic-and-apoptotic-markers
#15
Heba M Eltahir, Maiiada H Nazmy
BACKGROUND: Hepatic fibrosis is a major health problem that requires further medical attention. Proton pump inhibitors are proven to possess other therapeutic potentials apart of their acid anti-secretory actions. AIM OF THE WORK: To test possible anti-fibrotic effect of esomeprazole magnesium trihydrate in management of liver fibrosis compared to silymarin, the well-known hepatoprotective agent. MATERIALS & METHODS: 40 male albino rats were divided into 4 groups: normal control group; CCl4-treated group (1 mL/kg 40% CCl4, diluted in olive oil) I...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156514/esophageal-baseline-impedance-reflects-mucosal-integrity-and-predicts-symptomatic-outcome-with-proton-pump-inhibitor-treatment
#16
Chenxi Xie, Daniel Sifrim, Yuwen Li, Minhu Chen, Yinglian Xiao
Background/Aims: Esophageal baseline impedance, which is decreased in gastroesophageal reflux disease (GERD) patients, is related to the severity of acid reflux and the integrity of the esophageal mucosa. The study aims to compare the baseline impedance and the dilated intercellular spaces (DIS) within patients with typical reflux symptoms and to evaluate the correlation of baseline impedance with DIS, esophageal acid exposure, as well as the efficacy of proton pump inhibitor (PPI) treatment...
November 21, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29149805/observational-cohort-study-safety-outcomes-in-children-using-proton-pump-inhibitors-or-histamine-2-receptor-antagonists
#17
Eline Houben, Saga Johansson, Péter Nagy, Fernie J A Penning-van Beest, Ernst J Kuipers, Ron M C Herings
OBJECTIVE: Acid suppression with histamine-2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) is recommended for children with persistent gastroesophageal reflux disease symptoms. In this retrospective, observational postauthorization study, we aimed to assess and compare safety outcomes in pediatric first-time users of esomeprazole, other PPIs or H2RAs. METHODS: Data on children (aged 0-18 years) first dispensed esomeprazole, other PPIs or H2RAs between September 2008 and August 2011 was obtained from the Dutch PHARMO Database Network...
November 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29128277/a-fast-sensitive-and-high-throughput-method-for-the-determination-of-esomeprazole-in-dog-plasma-by-uhplc-ms-ms-application-to-formulation-development-of-the-compound-preparation-of-esomeprazole
#18
Ran Liu, Pei Li, Jie Xiao, Yidi Yin, Zheng Sun, Kaishun Bi, Qing Li
To investigate deeply into the preclinical pharmacokinetics and prescription design of esomeprazole, a sensitive, high throughput and robust UHPLC-MS/MS method had been developed and fully validated for the analysis of esomeprazole in dog plasma. Esomeprazole and diazepam (IS) were fast extracted from plasma by alkalified organic solvent, and separated on MP-C18 column with methanol and 0.1% formic acid. The quantification of esomeprazole and IS had been achieved using fragmentation transitions of m/z 346.1→198...
November 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29119724/evaluation-of-first-line-bismuth-containing-7-day-concomitant-quintuple-therapy-for-helicobacter-pylori-eradication
#19
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29105152/proton-pump-inhibitor-alters-oral-microbiome-in-gastrointestinal-tract-of-healthy-volunteers
#20
Tsuyoshi Mishiro, Kentaro Oka, Yasutoshi Kuroki, Motomichi Takahashi, Kasumi Tatsumi, Tsukasa Saitoh, Hiroshi Tobita, Norihisa Ishimura, Shuichi Sato, Shunji Ishihara, Joji Sekine, Koichiro Wada, Yoshikazu Kinoshita
BACKGROUND AND AIM: Acid suppressive agents including proton pump inhibitors (PPIs) are used as first-line treatment for various acid-related gastrointestinal disorders. Although known to profoundly reduce gastric acid production, their influence on inhibition of acid secretion as part of the function of the gastrointestinal tract microbiome remains to be elucidated. The aim of the present study was to examine the effects of PPI usage on oral and gut microbiota in healthy volunteers. METHODS: Ten healthy adult volunteers receiving no medications were enrolled...
November 4, 2017: Journal of Gastroenterology and Hepatology
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