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Mustafa Serinken, Cenker Eken, Özgür Karcıoğlu
BACKGROUND: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age. AIMS: The present study aimed to compare the effects of IV paracetamol to dexketoprofen in patients presented with primary dysmenorrhea to the emergency department. STUDY DESIGN: Randomized Controlled Trial. METHODS: Patients over 18 years old presented with pelvic pain related to menstruation were accepted as eligible for the study...
February 2, 2018: Balkan Medical Journal
Umut Demetoglu, Hakan Ocak, Suheyb Bilge
Oroantral communication (OAC) is the opening between the maxillary sinus and oral cavity. It may cause oroantral fistula or maxillary sinusitis if left untreated. The surgical closure of the OAC within 48 hours was recommended to avoid the complications like sinus infections. The aim of this study is to evaluate the treatment of OACs with plasma-rich fibrin (PRF) which is safe and easy to implement in the OACs.This study was conducted with the patients, who required the treatment of the OAC, which was developed after the posterior maxillary tooth extraction in the Dental and Maxillofacial Department of the Faculty of Dentistry in Adnan Menderes University...
February 26, 2018: Journal of Craniofacial Surgery
Jennifer P Pascali, Paolo Fais, Fabio Vaiano, Nicola Pigaiani, Stefano D'Errico, Sandra Furlanetto, Diego Palumbo, Elisabetta Bertol
Drug tampering practices, with the aim to increase availability of drug delivery and/or enhance drug effects, are accessible on Internet and are practiced by some portion of recreational drug users. Not rarely, recreational misuse may result in toxic and even fatal results. The aim of the present study was to assess the tampering risk of medicaments containing different formulations of an opioid in combination with paracetamol or dexketoprofen, following the procedures reported in dedicated forums on the web...
February 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
Dorota Mehrholz, Anna Emilia Urban, Marta Herstowska, Roman Nowicki, Wiesław Cubała, Wioletta Barańska-Rybak
OBJECTIVES: DRESS (drug reaction with eosinophilia and systemic syndrome) is qualified as hypersensitivity after drug reaction. This syndrome may occur due to any medication intake. There are three main groups of symptoms defining DRESS: skin lesions, hematological abnormalities and internal organ involvement. METHODS: A retrospective study was performed on a group of 261 patients with drug reactions hospitalized in the Clinic of Dermatology from 2004 until 2017...
December 30, 2017: Psychiatria Polska
Sergio Terracina, Chiara Robba, Anna Prete, Paola G Sergi, Federico Bilotta
BACKGROUND AND OBJECTIVE: In the last decades, in developed countries, spine procedures (surgical and percutaneous) had the highest absolute increase in case volume trend. Optimal approach to prevent and treat postoperative pain is continuously evolving. This systematic literature review presents evidence on safety and efficacy of pharmacological and non-pharmacological therapies to prevent and treat postoperative pain after lumbar spine procedures. DATABASES AND DATA TREATMENT: Publications listed in PUBMED and EMBASE were considered to identify randomized clinical trials suitable for inclusion in this systematic review...
February 2, 2018: Pain Practice: the Official Journal of World Institute of Pain
R Ortiz de la Tabla González, P Gómez Reja, D Moreno Rey, C Pérez Naranjo, I Sánchez Martín, M Echevarría Moreno
OBJECTIVE: To compare the analgesic efficacy of continuous interpectoral block (CIPB) compared to intravenous analgesia (IV) after breast surgery. MATERIAL AND METHOD: A prospective, comparative and randomised study of women aged from 18-75years, ASAI-III, operated for breast cancer. In group1 (CIPB) after general anaesthetic, an ultrasound-guided interpectoral catheter was placed and 30mL of 0.5% ropivacaine was administered through it. In the event of an increase in heart rate and blood pressure >15% after the surgical incision, intravenous fentanyl 1μg·kg-1 was administered, repeating the dose as necessary...
January 17, 2018: Revista Española de Anestesiología y Reanimación
Arturo Sanchez-Perez, Jesús Muñoz-Peñalver, María José Moya-Villaescusa, Carmen Sanchez-Matas
The fear of postoperative pain is often mentioned by patients as one of the factors that is most frequently associated with dental implants. In an attempt to reduce this factor, a single oral dose of 25 mg dexketoprofen trometamol (DKT) or PLACEBO was administered 15 minutes before implant surgery. One hundred patients who required single-implant treatments were randomly assigned to one of two blinded groups. The patients in the test group were given 25 mg of DKT (DKT group), and those in the control group were given 500 mg of vitamin C as a placebo (PLACEBO group)...
January 22, 2018: Journal of Oral Implantology
Gulen Melike Demirbolat, Levent Altintas, Sukran Yilmaz, Ismail Tuncer Degim
Nanoparticulate systems have been receiving a significant attention especially for the treatment of cancer but one of the main hurdles is to produce these developed and high tech nanosystems in large quantities. Anticancer drug formulations are generally designed for parenteral administrations but oral administration is still the most convenient route. In this study, orally applicable nano-sized chitosan nanoparticles (NPs) were successfully prepared using Nano Spray Dryer. It is possible to produce these NPs in large quantities by simply increasing the processing time using the machine without changing any parameter...
January 12, 2018: Journal of Pharmaceutical Sciences
Hugo F Miranda, Fernando Sierralta, Nicolás Aranda, Viviana Noriega, Juan Carlos Prieto
No abstract text is available yet for this article.
January 9, 2018: Pharmacological Reports: PR
Milind Y Nadkar, Mangesh Tiwaskar, Sanjay Kalra, Siddharth N Shah, B R Bansode, Anjanlal Dutta, Sarita Bajaj, Sameer Aggarwal, Yatan Pal Singh Balhara, A K Das, Puneet Dhamija, Y K Gupta, Jubbin Jacob, Sundeep Mishra, S N Narasingan, C K Ponde, Ram Prabhoo, Balakrishnan S, Manisha Sahay, R K Sahay, I Sathyamurthy, Shilpa Tiwaskar, Agam Vora
Chirally pure molecules or enantiomers are non-superimposable mirror images of each other with a chiral center (such as carbon, sulphur, nitrogen or phosphorous atom). An equimolar mixture of enantiomers forms a racemate. Chirally pure molecules (single enantiomers) are important in the field of drug discovery as the drug targets such as enzymes and receptors are enantioselective in nature. Clinical studies have demonstrated that chirally pure drugs exhibit different pharmacokinetic and metabolic profiles, reduced adverse events, improved safety profiles and similar therapeutic activity at lowered drug dosage as compared with the racemate in many therapeutic areas...
December 2017: Journal of the Association of Physicians of India
Vicente Esparza-Villalpando, Amaury Pozos-Guillén, David Masuoka-Ito, César Gaitán-Fonseca, Daniel Chavarría-Bolaños
Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017...
December 15, 2017: Drug Development Research
L Cáceres-Sánchez, J B García-Benítez, V Coronado-Hijón, M Montero-Pariente
OBJECTIVE: This study compares the efficacy in post-operative pain control of the intraarticular catheter compared to the epidural catheter after primary total knee arthroplasty. MATERIAL AND METHOD: Randomised clinical trial consisting of two groups of patients. A control group with intradural anaesthesia and an intraoperative epidural catheter (ropivacaine) and an intervention group using the same anaesthetic technique and an intraarticular catheter with an elastomeric pump (ropivacaine+dexketoprofen)...
January 2018: Revista Española de Cirugía Ortopédica y Traumatología
R A Moore, H J McQuay, J Tomaszewski, G Raba, D Tutunaru, N Lietuviete, J Galad, L Hagymasy, D Melka, J Kotarski, T Rechberger, B Fülesdi, A Nizzardo, C Guerrero-Bayón, S Cuadripani, B Pizà-Vallespir, M Bertolotti
Following publication of the original article [1], the authors reported that additional file 10 contained a typing error in the table "Percentage of responders (≥50% max TOTPAR) over two, four, six and eight hours (single-dose phase) (ITT Population)". The table is to be read as follows.
November 30, 2017: BMC Anesthesiology
María Victoria Toledo, Laura Estefanía Briand
This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called "chiral switch" in the pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented upon...
November 10, 2017: Critical Reviews in Biotechnology
Behcet Al, Mehmet Mustafa Sunar, Suat Zengin, Mustafa Sabak, Mustafa Bogan, Basri Can, Seval Kul, M Murat Oktay, Sevki Hakan Eren
OBJECTIVE: In this study, we aimed to compare the analgesic efficacy of intravenous dexketoprofen trometamol, fentanyl, and paracetamol in patients presenting to the emergency department with renal colic. MATERIALS AND METHOD: Data obtained from the emergency departments of Gaziantep University's Hospital for Research and Practice along with two other state hospitals in Gaziantep, Turkey between January 2016 and January 2017 was used for this study. A total of three hundred patients (n=300), who presented to the ER with complaints most common to renal colic whose diagnoses were subsequently confirmed with Computerized Tomography were included in the study...
September 14, 2017: American Journal of Emergency Medicine
A Montero Matamala, M Bertolotti, M P Contini, C Guerrero Bayón, A Nizzardo, I Paredes Lario, B Pizà Vallespir, S Scartoni, G Tonini, A Capriati, A Pellacani
Multimodal analgesia constitutes a common strategy in pain management. A tramadol hydrochloride 75 mg/dexketoprofen 25 mg oral fixed combination (TRAM/DKP 75 mg/25 mg) has been recently registered and released in Europe for the treatment of moderate-to-severe acute pain. This paper provides additional analyses on the results of two phase III clinical trials (DEX-TRA-04 and DEX-TRA-05) on postoperative pain to document its sustained effect. The analysis was applied to a modified intention-to-treat population (mITT, n = 933) of patients undergoing active treatment from the first dose, to assess the sustained effect of TRAM/DKP 75 mg/25 mg on pain intensity (PI-VAS 0-100) over 56 h from first drug intake...
June 2017: Drugs of Today
Elvira Mennillo, Augustine Arukwe, Gianfranca Monni, Valentina Meucci, Luigi Intorre, Carlo Pretti
The increased use of nonsteroidal anti-inflammatory drugs (NSAIDs) has resulted in their ubiquitous presence in the environment. The toxicological properties of these 2 widely prescribed NSAIDs, namely racemic ketoprofen and its enantiomer S(+)-ketoprofen (dexketoprofen), were evaluated, firstly, by acute and chronic toxicity tests using 3 representative model organisms (Vibrio fischeri, Pseudokirchneriella subcapitata, and Ceriodaphnia dubia) and, secondly, by evaluating the responses of biotransformation systems and multidrug resistance-associated proteins (MRP1/MRP2) using the Poeciliopsis lucida hepatocellular carcinoma 1 (PLHC-1) fish hepatic cell line...
August 10, 2017: Environmental Toxicology and Chemistry
Ana Dora Bonillo Martínez, Inés Carmen Rodríguez Galán, María Victoria Margarit Bellver
This pre-formulation study assays the capacity of the polyesteramide PADAS, poly (L-alanine-dodecanediol-L-alanine-sebacic), as an insoluble tablet excipient matrix for prolonged drug release. The flow properties of PADAS were suitable for tableting, and the compressibility of tablets containing exclusively PADAS was evaluated by ESEM observation of the microstructure. The tablets were resistant to crushing and non-friable and they did not undergo disintegration (typical features of an inert matrix). Tablets containing 33...
November 2017: AAPS PharmSciTech
Helen Gaskell, Sheena Derry, Philip J Wiffen, R Andrew Moore
BACKGROUND: This review is an update of "Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults" last updated in Issue 4, 2009. Ketoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) used to treat acute and chronic painful conditions. Dexketoprofen is the (S)-enantiomer, which is believed to confer analgesia. Theoretically dexketoprofen is expected to provide equivalent analgesia to ketoprofen at half the dose, with a consequent reduction in gastrointestinal adverse events...
May 25, 2017: Cochrane Database of Systematic Reviews
D Fornasari, M Allegri, S Gerboni, Guido Fanelli
 Acute and chronic pain have an important socio-economical impact. In order to help physicians to choose the appropriate drug, especially for cancer pain, in 1986 WHO has developed a three-step analgesic "ladder" for cancer pain relief in adults. Later it has also been used for acute pain and chronic non-cancer pain. In step I nonsteroidal anti-inflammatory drugs (NSAIDs) are considered with or without adjuvants, in step II the use of weak opioids for mild-moderate pain, with or without NSAIDs and adjuvant, is suggested, while the step III is reserved to strong opioids for moderate-severe pain with or without non-opioids or adjuvants...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
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