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https://www.readbyqxmd.com/read/28927656/features-and-outcomes-from-a-retrospective-study-of-570%C3%A2-hospitalized-chinese-patients-with-drug-induced-liver-injury
#1
Lili Pang, Wanna Yang, Fengqin Hou
AIMS: To investigate the clinical features and outcomes of hospitalized patients with drug-induced liver injury (DILI). METHODS: The medical records of hospitalized patients with DILI from January 1997 through July 2016 were reviewed. RESULTS: Five hundred seventy cases were reviewed, of which 381 (66.8%) were female. Four hundred fifty-eight cases (80.4%) presented with hepatocellular injury, 53 (9.3%) with cholestatic injury and 59 (10...
September 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28915873/a-prospective-cohort-study-on-ambient-air-pollution-and-respiratory-morbidities-including-childhood-asthma-in-adolescents-from-the-western-cape-province-study-protocol
#2
Toyib Olaniyan, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, Mark Davey, Kees de Hoogh, Dilys Berman, Bhawoodien Parker, Joy Leaner, Mohamed Aqiel Dalvie
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28895915/-autoimmune-like-drug-and-herb-induced-liver-injury-new-insights-into-molecular-pathogenesis
#3
REVIEW
Marcial Sebode, Lisa Schulz, Ansgar W Lohse
Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term "autoimmune(-like)" DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from "classical" DILI/HDS...
September 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28887374/rem-sleep-behavior-disorder-is-related-to-enteric-neuropathology-in-parkinson-disease
#4
Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Séverine Le Dily, Fabienne Vavasseur, Marie Dalichampt, Yann Péréon, Michel Neunlist, Pascal Derkinderen
OBJECTIVE: To determine whether REM sleep behavior disorder (RBD) in Parkinson disease (PD) is associated with lesions and dysfunctions of the autonomic nervous system by evaluating enteric phosphorylated α-synuclein histopathology (PASH) and permeability. METHODS: A total of 45 patients with PD were included in this cross-sectional study. RBD was diagnosed on the basis of a standardized clinical interview and confirmed by polysomnography. For each patient, 5 biopsies were taken at the junction between the sigmoid and descending colon during the course of a rectosigmoidoscopy...
September 8, 2017: Neurology
https://www.readbyqxmd.com/read/28873351/frequency-and-pathological-characteristics-of-drug-induced-liver-injury-in-a-tertiary-medical-center
#5
Mark Ettel, Gabriel Acosta Gonzalez, Shweta Gera, Ogechukwu Eze, Samuel Sigal, James S Park, Ruliang Xu
Drug-induced liver injury (DILI) accounts for approximately 10% of acute hepatitis cases. DILI can arise as idiosyncratic or intrinsic injury from hundreds of drugs, herbals, and nutritional supplements and is essential to recognize as one of the differential diagnoses of hepatitis in a liver biopsy. The purpose of this study is to investigate the frequency and pathological characteristics of DILI related to the variety of hepatotoxic agents. We searched our pathology database for all patients with hepatitis diagnosed on liver biopsy from January 2012 to May 2016, and selected patients with a diagnosis of DILI...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28868048/extracellular-vesicles-from-adipose-tissue-a-potential-role-in-obesity-and-type-2-diabetes
#6
REVIEW
Xuan Gao, Carlos Salomon, Dilys J Freeman
Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae, such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride can lead to adipose tissue inflammation and spillover of fatty acids from this tissue and accumulation of fatty acids as lipid droplets in ectopic sites, such as liver and muscle. Extracellular vesicles (EVs) are released from adipocytes and have been proposed to be involved in adipocyte/macrophage cross talk and to affect insulin signaling and transforming growth factor β expression in liver cells leading to metabolic disease...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28865237/dose-dependent-acute-liver-injury-with-hypersensitivity-features-in-humans-due-to-a-novel-microsomal-prostaglandin-e-synthase-1-inhibitor
#7
Yan Jin, Arie Regev, Jeanelle Kam, Krista Phipps, Claire Smith, Judith Henck, Kristina Campanale, Leijun Hu, D Greg Hall, Xiao Yan Yang, Masako Nakano, Terry Ann McNearney, Jack Uetrecht, William Landschulz
AIM: LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies and a single ascending dose study demonstrated an acceptable toxicity, safety, and tolerability profile. METHODS: Healthy subjects were randomised to receive LY3031207 (25, 75, and 275 mg), placebo, or celecoxib (400 mg) once daily for 28 days. The safety, tolerability, and pharmacokinetic and pharmacodynamic profiles of LY3031207 were evaluated...
September 2, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28865179/histopathological-challenges-in-suspected-drug-induced-liver-injury
#8
REVIEW
David E Kleiner
When a patient with suspected drug-induced liver injury (DILI) undergoes liver biopsy, the pathologist is confronted with two major challenges. The first and most important is to establish the pattern(s) of injury which are present. Patterns of injury represent stereotypical responses of an organ to injury and relate to specific etiologies of liver damage. The pattern of injury and the histological details of that injury can then be analyzed with respect to the patient's intercurrent diseases and medication history...
September 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28856081/genetic-factors-influencing-drug-induced-liver-injury-do-they-have-a-role-in-prevention-and-diagnosis
#9
REVIEW
Kathleen E Clare, Michael H Miller, John F Dillon
PURPOSE OF REVIEW: The pathogenesis of DILI is currently unknown; however, research has shown strong genetic associations with some DILIs. This paper describes the variant alleles uncovered by GWAS and discusses their potential role as susceptibility biomarkers. RECENT FINDINGS: An association with HLADRB1*15:01 and amoxicillin/clavulanate DILI has been shown by a number of research groups. The presence of the HLA-B*57:01 allele has been associated with an 81-fold increased risk of flucloxacillin DILI...
2017: Current Hepatology Reports
https://www.readbyqxmd.com/read/28855920/occupational-exposure-to-needle-stick-and-sharp-injuries-and-associated-factors-among-health-care-workers-in-awi-zone-amhara-regional-state-northwest-ethiopia-2016
#10
Abebe Dilie, Desalegn Amare, Tenaw Gualu
BACKGROUND: Needle stick and sharp injuries were one of the major risk factors for blood and body fluid borne infections at health care facilities. OBJECTIVE: To assess occupational exposure to needle stick and sharp injuries and associated factors among health care workers in Awi zone, 2016. METHODS: institutional based cross-sectional study was conducted among 193 health care workers. Study participants were selected using systematic random sampling technique...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28842581/a-first-in-human-study-of-the-novel-hiv-fusion-inhibitor-c34-peg4-chol
#11
Killian Quinn, Cinzia Traboni, Sujan Dily Penchala, Georgios Bouliotis, Nicki Doyle, Vincenzo Libri, Saye Khoo, Deborah Ashby, Jonathan Weber, Alfredo Nicosia, Riccardo Cortese, Antonello Pessi, Alan Winston
Long-acting injectable antiretroviral (LA-ARV) drugs with low toxicity profiles and propensity for drug-drug interactions are a goal for future ARV regimens. C34-PEG4-Chol is a novel cholesterol tagged LA HIV-fusion-inhibitor (FI). We assessed pre-clinical toxicology and first-in-human administration of C34-PEG4-Chol. Pre-clinical toxicology was conducted in 2 species. HIV-positive men were randomised to a single subcutaneous dose of C34-PEG4-Chol at incrementing doses or placebo. Detailed clinical (including injection site reaction (ISR) grading), plasma pharmacokinetic (time-to-minimum-effective-concentration (MEC, 25 ng/mL) and pharmacodynamic (plasma HIV RNA) parameters were assessed...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839445/laparoscopic-ultrasonography-as-an-alternative-to-intraoperative-cholangiography-during-laparoscopic-cholecystectomy
#12
REVIEW
Alexandra Dili, Claude Bertrand
AIM: To assess the role of laparoscopic ultrasound (LUS) as a substitute for intraoperative cholangiography (IOC) during cholecystectomy. METHODS: We present a MEDLINE and PubMed literature search, having used the key-words "laparoscopic intraoperative ultrasound" and "laparoscopic cholecystectomy". All relevant English language publications from 2000 to 2016 were identified, with data extracted for the role of LUS in the anatomical delineation of the biliary tract, detection of common bile duct stones (CBDS), prevention or early detection of biliary duct injury (BDI), and incidental findings during laparoscopic cholecystectomy...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28831528/association-between-infection-and-severe-drug-adverse-reactions-an-analysis-using-data-from-the-japanese-adverse-drug-event-report-database
#13
Takuya Imatoh, Kimie Sai, Chisato Fukazawa, Yasushi Hinomura, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Katsunori Segawa, Yoshiro Saito
PURPOSE: It has been reported recently that immune reactions are involved in the pathogenesis of certain types of adverse drug reactions (ADRs). We aimed to determine the associations between infections and drug-induced interstitial lung disease (DILD), rhabdomyolysis, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), or drug-induced liver injury (DILI) using a spontaneous adverse drug event reporting database in Japan. METHODS: The reported cases were classified into three categories (anti-infectious drug group, concomitant infection group, and non-infection group) based on the presence of anti-infectious drugs (either as primary suspected drug or concomitant drug) and infectious disease...
August 22, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28831409/the-idiosyncratic-drug-induced-gene-expression-changes-in-hepg2-cells
#14
J Jiang, K Mathijs, L Timmermans, S M Claessen, A Hecka, J Weusten, R Peters, J H van Delft, J C S Kleinjans, D G J Jennen, T M de Kok
The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We exposed HepG2 cells with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, in the presence (I+ and N+) or absence (I- and N-) of a cytokine mix for 6, 12 and 24 h. To investigate the genome-wide expression patterns, microarray was performed using the Agilent 4×44K Whole Human Genome chips...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28820004/drug-induced-liver-injury-in-children-clinical-observations-animal-models-and-regulatory-status
#15
Qiang Shi, Xi Yang, James J Greenhaw, Alec Thomas Salminen, Gary M Russotti, William F Salminen
Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse drug reactions throughout all age groups, less than 10% of all clinical DILI cases, and around 20% of all acute liver failure cases in children. The overall DILI susceptibility in children has been assumed to be lower than in adults. Nevertheless, controversial evidence is emerging about children's sensitivity to DILI, with children's relative susceptibility to DILI appearing to be highly drug-specific. The culprit drugs in cDILI are similar but not identical to DILI in adults (aDILI)...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28809737/acute-liver-failure-due-to-etodolac-a-selective-cycloxygenase-2-cox-2-inhibitor-non-steroidal-anti-inflammatory-drug-established-by-rucam-based-causality-assessment
#16
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepatotoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF. Antibiotics are the most common cause of idiosyncratic DILI as well as DILI induced ALF. Etodolac is a selective cycloxygenase- 2 (COX -2) inhibitor non-steroidal anti-inflammatory drug used as an analgesic and anti-inflammatory in musculoskeletal diseases. Severe liver impairment is extremely rare...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28795997/celecoxib-induced-liver-injury-analysis-of-published-case-reports-and-cases-reported-to-the-food-and-drug-administration
#17
Pavan K Mukthinuthalapati, Robert J Fontana, Raj Vuppalanchi, Naga Chalasani, Marwan Ghabril
BACKGROUND: Celecoxib is a widely prescribed nonsteroidal anti-inflammatory drug, and has been associated with rare instances of idiosyncratic drug-induced liver injury (DILI). The aim of this study is to describe and analyze the salient features of published cases of celecoxib DILI. MATERIALS AND METHODS: A literature search using common terms for liver injury cross-referenced with celecoxib was undertaken from the year 2000 through June 2016. Identified cases were analyzed with respect to reported demographic and clinical data with descriptive...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28772086/highlights-of-drug-and-herb-induced-liver-injury-in-the-literature-from-2016-how-best-to-translate-new-information-into-clinical-practice
#18
Omar Shahbaz, Sandeep Mahajan, James H Lewis
INTRODUCTION: More than 1500 papers on drug-induced liver injury (DILI) and herb-induced liver injury (HILI) were published in 2016, many of which have the potential to impact clinical practice. AREAS COVERED: Clinical studies and case series that lent themselves to new concepts or directions in diagnosing, preventing, and treating DILI were selected for inclusion. Epidemiology of DILI in large prospective registries was highlighted, including the US DILIN network and Spanish DILI registry...
August 3, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28770534/antidepressant-induced-acute-liver-injury-a-case-control-study-in-an-italian-inpatient-population
#19
Carmen Ferrajolo, Cristina Scavone, Monia Donati, Oscar Bortolami, Giovanna Stoppa, Domenico Motola, Alfredo Vannacci, Alessandro Mugelli, Roberto Leone, Annalisa Capuano
INTRODUCTION: Pre-marketing clinical trials show that antidepressant-induced liver injury seems to be a rare adverse event. Because of short follow-up trial duration, the incidence of liver injury due to antidepressant use could be underestimated. OBJECTIVES: We aimed to quantify the risk of acute liver injury associated with antidepressant use through a case-control analysis among an inpatient population. METHODS: A multicenter study was carried out in nine Italian hospitals from October 2010 to January 2014, within the DILI-IT (Drug-Induced Liver Injury in Italy) study project...
August 2, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28762471/clinical-presentation-of-terbinafine-induced-severe-liver-injury-and-the-value-of-laboratory-monitoring-a-critically-appraised-topic
#20
REVIEW
O N Kramer, J Albrecht
CONTEXT: Many physicians monitor liver function tests during terbinafine therapy. OBJECTIVE: Evaluate the symptoms of published cases of terbinafine associated severe DILI (Drug Induced Liver Injury) to assess the utility of laboratory monitoring. DATA SOURCES: We based our search on the Liver Tox database of the National Institute of Health, but searched PUBMED as well as EMBASE. In addition, we hand-searched the references of the papers we found...
August 1, 2017: British Journal of Dermatology
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