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https://www.readbyqxmd.com/read/29771932/a-multi-center-preclinical-study-of-gadoxetate-dce-mri-in-rats-as-a-biomarker-of-drug-induced-inhibition-of-liver-transporter-function
#1
Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers...
2018: PloS One
https://www.readbyqxmd.com/read/29754670/knowledge-to-action-rationale-and-design-of-the-patient-centered-care-transitions-in-heart-failure-pact-hf-stepped-wedge-cluster-randomized-trial
#2
Harriette G C Van Spall, Shun Fu Lee, Feng Xie, Dennis T Ko, Lehana Thabane, Quazi Ibrahim, Peter R Mitoff, Michael Heffernan, Manish Maingi, Michael C Tjandrawidjaja, Mohammad I Zia, Mohamed Panju, Richard Perez, Kim D Simek, Liane Porepa, Ian D Graham, R Brian Haynes, Dilys Haughton, Stuart J Connolly
INTRODUCTION: Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional care model. METHODS: Adopting an integrated Knowledge Translation (iKT) approach in which decision-makers and clinicians are partners in research, we implement and test the effectiveness of PACT-HF among patients hospitalized for HF...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29751876/recent-advances-in-the-histopathology-of-drug-induced-liver-injury
#3
REVIEW
David E Kleiner
Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29750764/linezolid-containing-treatment-regimens-for-tuberculosis-in-children
#4
Luis M Prieto, Begoña Santiago, Teresa Del Rosal, Begoña Carazo, Ana B Jiménez, Beatriz Pérez-Gorricho, Felipe Rubio, Alfredo Tagarro, Daniel Blázquez, David Moreno-Pérez, María J Mellado, Fernando Baquero-Artigao
BACKGROUND: In recent years there is an increasing interest in the use of linezolid for the treatment of tuberculosis (TB). METHODS: Patients under 18 years of age who received linezolid within the Spanish Pediatric TB Network (pTBred) from 2001 to 2016 were retrospectively included. Treatment characteristics, adverse events (AEs) and outcomes were analyzed. RESULTS: Fifteen children were included (53% male) with a median age of 3.6 years (IQR: 1...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29747593/companionship-during-facility-based-childbirth-results-from-a-mixed-methods-study-with-recently-delivered-women-and-providers-in-kenya
#5
Patience Afulani, Caroline Kusi, Leah Kirumbi, Dilys Walker
BACKGROUND: Research suggests that birth companionship, and in particular, continuous support during labor and delivery, can improve women's childbirth experience and birth outcomes. Yet, little is known about the extent to which birth companionship is practiced, as well as women and providers' perceptions of it in low-resource settings. This study aimed to assess the prevalence and determinants of birth companionship, and women and providers' perceptions of it in health facilities in a rural County in Western Kenya...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29735795/lncrna-regulated-autophagy-and-its-potential-role-in-drug-induced-liver-injury
#6
Juan Zhou, Yi Li, XinYu Liu, Yunzhu Long, Jun Chen
BACKGROUND AND AIM: Autophagy and its regulated pathways participate in many important cellular physiology and pathological processes involving protein aggregates, damaged mitochondria, excessive peroxisomes, ribosomes, and invading pathogens. This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during drug-induced liver injury (DILI). MATERIAL AND METHODS: DILI, autophagy, autophagy-related genes (ATGs), and lncRNA were used as key words to search published studies from PubMed, Google Scholar, and Web of Science...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29729369/reference-intervals-for-putative-biomarkers-of-drug-induced-liver-injury-and-liver-regeneration-in-healthy-human-volunteers
#7
Ben Francis, Joanna I Clarke, Lauren E Walker, Nathalie Brillant, Andrea L Jorgensen, B Kevin Park, Munir Pirmohamed, Daniel J Antoine
BACKGROUND & AIMS: The potential of mechanistic biomarkers to improve the prediction of drug-induced liver injury (DILI) and hepatic regeneration is widely acknowledged. We sought to determine reference intervals for new biomarkers of DILI and regeneration as well as to characterize their natural variability and impact of diurnal variation. METHODS: Serum samples from 200 healthy volunteers were recruited as part of a cross sectional study; of these, 50 subjects had weekly serial sampling over 3 weeks, while 24 had intensive blood sampling over a 24h period...
May 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29723689/development-and-validation-of-a-test-to-identify-drugs-that-cause-idiosyncratic-drug-induced-liver-injury
#8
Andreas Benesic, Isabelle Rotter, Diana Dragoi, Sabine Weber, Marie-Luise Buchholtz, Alexander L Gerbes
BACKGROUND & AIMS: Idiosyncratic drug-induced liver injury (iDILI) is one of the most challenging diagnoses in hepatology. It is frequently impossible to identify the agent that has caused iDILI in patients who take multiple medicines. We developed an in vitro method to identify drugs that cause liver injury in patients, based on drug toxicity to monocyte-derived hepatocyte-like (MH) cells from patient blood samples. We then collected data on patients who were re-exposed to drugs found to be toxic in the MH test to validate test performance...
April 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29722540/impact-of-physicochemical-properties-on-dose-and-hepatotoxicity-of-oral-drugs
#9
Paul D Leeson
A database containing maximum daily doses of 1841 marketed oral drugs was used to examine the influence of physicochemical properties on dose and hepatotoxicity (drug induced liver injury, DILI). Drugs in the highest ~20% dose range had significantly reduced mean lipophilicity and molecular weight, increased fractional surface area, increased % of acids and decreased % of bases, versus drugs in the lower ~60% dose range. Drugs in the ~20-40% dose range had intermediate mean properties, similar to the mean values for the full drug set...
May 3, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29722533/advancing-predictive-hepatotoxicity-at-the-intersection-of-experimental-in-silico-and-artificial-intelligence-technologies
#10
Keith Fraser, Dylan M Bruckner, Jonathan S Dordick
Adverse drug reactions (ADRs), particularly those that result in drug-induced liver injury (DILI) is a major cause of drug failure in clinical trials and drug withdrawals. Hepatotoxicity-mediated drug attrition occurs despite substantial investments of time and money in developing cellular assays, animal models and computational models to predict its occurrence in humans. Underperformance in predicting hepatotoxicity associated with drugs and drug candidates has been attributed to existing gaps in our understanding of the mechanisms involved in driving hepatic injury after these compounds perfuse and are metabolized by the liver...
May 3, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29719358/antipsychotic-drugs-and-liver-injury
#11
Qinyu Lv, Zhenghui Yi
In October 2015, the drug-induced liver diseases group of the Chinese Society of Hepatology drafted and published the first Diagnosis and Treatment Guidelines on Drug-induced Liver Injury in China, giving suggestions on the diagnosis and treatment of drug-induced liver injury (DILI). As a psychiatrist, I have found that in clinical practice both typical and new antipsychotic drugs can induce liver injury to varying degrees. Therefore, it is necessary to quickly and accurately determine the cause of liver injury and the type and severity of injury and establish a solution...
February 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29708070/drug-induced-cholestasis-mechanisms-models-and-markers
#12
Sagnik Chatterjee, Pieter Annaert
Drug-induced cholestasis is a risk factor in progression of drug candidates, and poses serious health hazard if not detected before going into human. Intrahepatic accumulation of bile acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. The major challenges in obtaining a complete understanding of drug-induced cholestasis lies in the complexity of BA-mediated toxicity mechanisms and the impact of bile acids at different 'targets' such as transporters, enzymes and nuclear receptors...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29642817/rheumatic-heart-disease-in-timor-leste-school-students-an-echocardiography-based-prevalence-study
#13
Kimberly Davis, Bo Remenyi, Anthony Dk Draper, Januario Dos Santos, Noel Bayley, Elizabeth Paratz, Benjamin Reeves, Alan Appelbe, Andrew Cochrane, Timothy D Johnson, Laura M Korte, Ivonia M Do Rosario, Inez T Da Silva Almeida, Kathryn V Roberts, Jonathan R Carapetis, Joshua R Francis
OBJECTIVES: To determine the prevalence of rheumatic heart disease (RHD) in school-aged children and young people in Timor-Leste. DESIGN: Prospective cross-sectional survey. Echocardiography was performed by Australian cardiologists to determine the presence of RHD. Demographic data were also collected. Patients in whom RHD was detected were entered into a register to allow monitoring of adherence to secondary prophylaxis; the first dose of benzathine penicillin G (BPG) was administered on the day of screening...
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29621595/extracellular-vesicles-as-potential-biomarkers-for-alcohol-and-drug-induced-liver-injury-and-their-therapeutic-applications
#14
REVIEW
Young-Eun Cho, Byoung-Joon Song, Mohammed Akbar, Moon-Chang Baek
Extracellular vesicles (EVs) are small membranous vesicles originating from various cells and tissues, including the liver parenchymal hepatocytes and nonparenchymal cells such as Kupffer and stellate cells. Recently, the pathophysiological role of EVs, such as exosomes and microvesicles, has been increasingly recognized based on intercellular communications. These EVs travel through the circulating blood and interact with specific cells and then deliver their cargos such as nucleic acids and proteins into recipient cells...
April 3, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29616137/video-monitoring-a-simulation-based-quality-improvement-program-in-bihar-india
#15
Jessica Dyer, Hilary Spindler, Amelia Christmas, Malay Bharat Shah, Melissa Morgan, Susanna R Cohen, Jason Sterne, Tanmay Mahapatra, Dilys Walker
Background: Simulation-based training has become an accepted clinical training andragogy in high-resource settings with its use increasing in low-resource settings. Video recordings of simulated scenarios are commonly used by facilitators. Beyond using the videos during debrief sessions, researchers can also analyze the simulation videos to quantify technical and nontechnical skills during simulated scenarios over time. Little is known about the feasibility and use of large-scale systems to video record and analyze simulation and debriefing data for monitoring and evaluation in low-resource settings...
April 2018: Clinical Simulation in Nursing
https://www.readbyqxmd.com/read/29610668/hcfc-123-induced-toxic-hepatitis-and-death-at-a-korean-fire-extinguisher-manufacturing-facility-a-case-series
#16
Mu Young Shin, Jong Soo Park, Hae Dong Park, Jihye Lee
Background: Exposure to sustained high concentrations of HCFC-123 is known to be hepatotoxic. We report two simultaneous cases of toxic hepatitis related to exposure to 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123), a common refrigerant, at a Korean fire extinguisher manufacturing facility. Case presentation: Patients A and B were men aged 21 and 22 years, respectively, with no notable medical histories. They had recently started working for a manufacturer of fire extinguishers...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29610385/coordinating-agmip-data-and-models-across-global-and-regional-scales-for-1-5%C3%A2-c-and-2-0%C3%A2-c-assessments
#17
Cynthia Rosenzweig, Alex C Ruane, John Antle, Joshua Elliott, Muhammad Ashfaq, Ashfaq Ahmad Chatta, Frank Ewert, Christian Folberth, Ibrahima Hathie, Petr Havlik, Gerrit Hoogenboom, Hermann Lotze-Campen, Dilys S MacCarthy, Daniel Mason-D'Croz, Erik Mencos Contreras, Christoph Müller, Ignacio Perez-Dominguez, Meridel Phillips, Cheryl Porter, Rubi M Raymundo, Ronald D Sands, Carl-Friedrich Schleussner, Roberto O Valdivia, Hugo Valin, Keith Wiebe
The Agricultural Model Intercomparison and Improvement Project (AgMIP) has developed novel methods for Coordinated Global and Regional Assessments (CGRA) of agriculture and food security in a changing world. The present study aims to perform a proof of concept of the CGRA to demonstrate advantages and challenges of the proposed framework. This effort responds to the request by the UN Framework Convention on Climate Change (UNFCCC) for the implications of limiting global temperature increases to 1.5°C and 2...
May 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29609830/safety-data-and-withdrawal-of-hepatotoxic-drugs
#18
Samy Babai, Laurent Auclert, Hervé Le-Louët
BACKGROUND AND AIM: The occurrence of drug induced liver injury (DILI) is the most common reason of post-marketing withdrawals. DILI in humans is difficult to predict using in vitro cytotoxicity screening and animal studies. A review of hepatotoxicity data was performed with the aim of identifying relevant factors that could have predicted the occurrence of serious DILI. METHODS: The drugs withdrawn from the market due to hepatotoxicity in Europe and/or in USA either by marketing authorization holders or by Regulatory agencies from 1997 to 2016 were selected...
February 21, 2018: Thérapie
https://www.readbyqxmd.com/read/29607530/systematic-review-drug-induced-liver-injury-alternative-causes-in-case-series-as-confounding-variables
#19
REVIEW
Rolf Teschke, Gaby Danan
AIMS: Drug-induced liver injury (DILI) is rare as compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case series of DILI for alternative causes. METHODS: Pertinent studies were identified using a computerized search of the Medline database for publications from 1993 through 30 October 2017...
April 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29607414/pharmacoeconomics-of-three-therapeutic-schemes-for-anti-tuberculosis-therapy-induced-liver-injury-in-china
#20
Yu Chen, Peng Ye, Chongwu Ren, Pengfei Ren, Zheng Ma, Lin Zhang, Wenliang Zhou, Changjie Jiang
To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). Methods: In the construction of a decision tree model, the efficacy and safety parameters came from the results of the randomized, controlled trial conducted here, the effect parameters were derived from expert advice, and the cost parameters, such as usage specification, number, and unit price, came from literature, expert advice, and so on. Results: The cost-effectiveness analysis (CEA) based on the effect degrees showed that bicyclol had the best effect (4...
2018: Open Medicine (Warsaw, Poland)
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