keyword
https://read.qxmd.com/read/38536128/drug-induced-liver-injury-during-a-glaucoma-neuroprotection-clinical-trial
#1
JOURNAL ARTICLE
Aakriti Garg Shukla, George A Cioffi, Jeffrey M Liebmann
There are several ongoing, worldwide clinical trials with a cumulative target enrollment of over 1300 participants on the role of nicotinamide (a specific form of vitamin B3) as a therapeutic neuroprotective treatment for glaucoma. We describe a serious adverse event of drug-induced liver injury (DILI) likely related to the use of 3 grams/day nicotinamide in a glaucoma clinical trial (clinicaltrials.gov identifier: NCT05695027) based in the United States. This report is important to share with the medical community, as other participants in glaucoma nicotinamide trials globally may have similar adverse events and many patients are using nicotinamide as a health supplement without medical supervision...
March 28, 2024: Journal of Glaucoma
https://read.qxmd.com/read/38535469/isolation-and-purification-of-chitosan-oligosaccharides-mw-%C3%A2-1000-and-their-protective-effect-on-acute-liver-injury-caused-by-ccl-4
#2
JOURNAL ARTICLE
Kai Wang, Dawei Yu, Yan Bai, Hua Cao, Jiao Guo, Zhengquan Su
Chitosan oligosaccharides are the degradation products of chitin obtained from the shell extracts of shrimps and crabs. Compared with chitosan, chitosan oligosaccharides have better solubility and a wider application range. In this study, high-molecular-weight chitosan oligosaccharides (COST, chitosan oligosaccharides, MW ≤ 1000) were isolated and purified by a GPC gel column, and the molecular weight range was further reduced to obtain high-purity and low-molecular-weight chitosan (COS46). Compared with COST, COS46 is better at inhibiting CCl4 -induced cell death, improving cell morphology, reducing ALT content, and improving cell antioxidant capacity...
March 8, 2024: Marine Drugs
https://read.qxmd.com/read/38534974/protective-effects-of-propolis-and-chitosan-nanoparticles-against-ibuprofen-induced-hepatotoxicity-in-albino-rats
#3
JOURNAL ARTICLE
Fajer M AlKandari, Hussein S Mohamed, Sayed A Ahmed, Basant Mahmoud, Asmaa M Mahmoud
Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38530825/application-of-covalent-binding-body-burden-in-the-h%C3%AE-rel-human-hepatocyte-coculture-model-for-reactivity-risk-assessment-of-metabolically-low-turnover-drugs
#4
JOURNAL ARTICLE
Jackie Shang, Kevin J Coe, Heng Keang Lim, Lu Chen, Buddha B Khatri, Rhys Salter, Kaushik Mitra, Ramaswamy Iyer
The human hepatocyte suspension model has been a valuable tool to study covalent binding (CVB) for compounds that form reactive metabolites. However, accurately measuring CVB values with the suspension model becomes challenging for metabolically low turnover compounds. In this study, we evaluated the HμREL human hepatocyte coculture model relative to existing literature using human hepatocyte suspension for drugs of known drug-induced liver injury category. Our results indicate that this coculture model provides ample metabolic turnover to reproducibly measure CVB...
March 26, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38529697/has-the-rescheduling-of-modified-release-paracetamol-in-australia-affected-the-frequency-of-overdoses
#5
JOURNAL ARTICLE
Michaela J Ryan, Andis Graudins, Nicole O'Shea, Firouzeh Noghrehchi, Anselm Wong
OBJECTIVES: In June 2020, modified-release paracetamol (paracetamol-MR) preparations were up-scheduled from schedule-2 (available in pharmacy) to schedule-3 (available by request to a pharmacist only). The present study aims to ascertain whether up-scheduling affected the frequency of paracetamol-MR overdoses. METHODS: This is a retrospective cohort study of two data sets from 1 June 2017 to 31 May 2022. Monash Health data were extracted using the diagnosis of paracetamol overdose coding and electronic medical records data...
March 26, 2024: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/38528719/difference-in-the-mechanism-of-iron-overload-enhanced-acute-hepatotoxicity-induced-by-thioacetamide-and-carbon-tetrachloride-in-rats
#6
JOURNAL ARTICLE
Yohei Inai, Takeshi Izawa, Tomomi Kamei, Sho Fujiwara, Miyuu Tanaka, Jyoji Yamate, Mitsuru Kuwamura
Iron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4 ). Hepatic and systemic iron overload were seen in the 0...
March 25, 2024: Toxicologic Pathology
https://read.qxmd.com/read/38527016/adoption-of-policies-to-improve-respectful-maternity-care-in-timor-leste
#7
JOURNAL ARTICLE
Angelina da Costa Fernandes, Stefanus Supriyanto, Chatarina Umbul Wahyuni, Hari Basuki Notobroto, Alexandra Gregory, Kayli Wild
INTRODUCTION: There are now well-established global standards for supporting improvement in women's experience of maternity services, including frameworks for the prevention of mistreatment during childbirth. To support initiatives to improve the quality of care in maternal health services in Timor-Leste, we examine the adoption of global respectful maternity care standards in the national intrapartum care policy and in three urban birth facilities in Dili. METHODS: From May to July 2022, we conducted a desk review of the Timor-Leste National Intrapartum Care Standards and Clinical Protocols for Referral Facilities and Community Health Centres...
2024: PloS One
https://read.qxmd.com/read/38526593/trans-2-nonadecyl-4-hydroxymethyl-1-3-dioxolane-tnhd-purified-from-freshwater-clams-markedly-alleviates-dimethylnitrosamine-induced-hepatic-fibrosis
#8
JOURNAL ARTICLE
Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan
Liver fibrosis occurs due to injury or inflammation, which results in the excessive production of collagen and the formation of fibrotic scar tissue that impairs liver function. Despite the limited treatment options available, freshwater clams may hold promise in the treatment of liver fibrosis. In this study, we demonstrated the effects of ethanol extract of freshwater clam (FCE), ethyl acetate extract of FCE (EA-FCE), and trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) on liver fibrosis induced by dimethylnitrosamine (DMN)...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38522313/multi-omics-reveals-that-5-o-methylvisammioside-prevention-acute-liver-injury-in-mice-by-regulating-the-tnf-mapk-nf-%C3%AE%C2%BAb-arachidonic-acid-pathway
#9
JOURNAL ARTICLE
Tingwen Zhang, Yue Zhong, Yan Shi, Chengcheng Feng, Lu Xu, Zheng Chen, Xin Sun, Yan Zhao, Xialin Sun
BACKGROUND: The pathogenesis of acute liver injury (ALI) has been a pressing issue in the medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from Saposhnikovia divaricata (Turcz.) Schischk has excellent anti-inflammatory properties. However, the mechanism by which MeV protects against ALI still needs to be deeply investigated. PURPOSE: In the present study, we established an acetaminophen (APAP) -induced ALI mouse model and pre-protected the mice with MeV...
March 19, 2024: Phytomedicine
https://read.qxmd.com/read/38522265/host-determinants-and-responses-underlying-sars-cov-2-liver-tropism
#10
REVIEW
Natalie Heinen, Mara Klöhn, Saskia Westhoven, Richard Jp Brown, Stephanie Pfaender
Hepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liver autopsies and the susceptibility of explanted human hepatocytes to infection...
March 23, 2024: Current Opinion in Microbiology
https://read.qxmd.com/read/38521541/cytokeratin-18-is-a-sensitive-biomarker-of-alanine-transaminase-increase-in-a-placebo-controlled-randomized-crossover-trial-of-therapeutic-paracetamol-dosing-path-bp-biomarker-sub-study
#11
JOURNAL ARTICLE
Kathleen M Scullion, Iain M MacIntyre, Sian Sloan-Dennison, Benjamin Clark, Paul Fineran, Joanne Mair, David Creasey, Cicely Rathmell, Karen Faulds, Duncan Graham, David J Webb, James W Dear
Drug-induced liver injury (DILI) is a challenge in clinical medicine and drug development. Highly sensitive novel biomarkers have been identified for detecting DILI following a paracetamol overdose. The study objective was to evaluate biomarker performance in a 14-day trial of therapeutic dose paracetamol. The PATH-BP trial was a double-blind, placebo-controlled, crossover study. Individuals (n = 110) were randomized to receive 1 g paracetamol 4×daily or matched placebo for 2 weeks followed by a 2-week washout before crossing over to the alternate treatment...
March 23, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38521487/sulfide-catabolism-in-hibernation-and-neuroprotection
#12
JOURNAL ARTICLE
Fumito Ichinose, Allyson Hindle
The mammalian brain is exquisitely vulnerable to lack of oxygen. However, the mechanism underlying the brain's sensitivity to hypoxia is incompletely understood. In this narrative review, we present a case for sulfide catabolism as a key defense mechanism of the brain against acute oxygen shortage. We will examine literature on the role of sulfide in hypoxia/ischemia, deep hibernation, and leigh syndrome patients, and present our recent data that support the neuroprotective effects of sulfide catabolism and persulfide production...
March 21, 2024: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/38521426/astragaloside-iv-ameliorates-cisplatin-induced-liver-injury-by-modulating-ferroptosis-dependent-pathways
#13
JOURNAL ARTICLE
Jianan Guo, Yifei Le, Aini Yuan, Jing Liu, Hang Chen, Jiannan Qiu, Cui Wang, Xiaobing Dou, Xingyu Yuan, Dezhao Lu
ETHNOPHARMACOLOGICAL RELEVANCE: The use of antineoplastic drugs, such as cisplatin, in clinical practice can cause adverse effects in patients, such as liver injury, which limits their long-term use. Therefore, there is an urgent need to develop alternative therapeutic strategies or drugs to minimize cisplatin-induced liver injury. Huangqi, the root of Astragalus membranaceus, is extensively used in traditional Chinese medicine (TCM) and has been employed in treating diverse liver injuries...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38515844/case-report-minocycline-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome-a-case-report-and-literature-review
#14
Zhe Zhao, Ming Lu, Yingqiu Ying
Minocycline is a tetracycline commonly used for several dermatological diseases. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but severe adverse event which can be caused by minocycline. An 18-year-old male patient developed fever, acute rash, pharyngeal pain, lymphadenopathy, hematologic abnormalities, increased creatinine level, elevated liver enzyme levels, and splenomegaly 4 weeks after the oral treatment of minocycline, 100 mg daily, for acne. Once diagnosed with DRESS syndrome, intravenous methylprednisolone was applied and his clinical manifestations and laboratory results remarkably improved...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38514990/unconjugated-hyperbilirubinemia-in-acetaminophen-related-acute-liver-failure
#15
JOURNAL ARTICLE
Marie Philippart, Jean-Baptiste Mesland, Vincent Haufroid, Christine Collienne, Philippe Hantson
BACKGROUND In the absence of liver transplantation, the natural history of acetaminophen-induced liver failure is characterized by a progressive increase of liver function tests, including bilirubin mainly as its conjugated form. The presence of high levels of unconjugated bilirubin is more unusual; its etiology is unclear and its prognostic factor has been poorly investigated. CASE REPORT A 52-year-old man with a history of chronic analgesics, alcohol, and illicit drug abuse developed acute liver failure in relationship with the ingestion of largely supra-therapeutic doses of acetaminophen over the days preceding admission...
March 22, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38514262/-study-based-on-the-acetaldehyde-dehydrogenase-2-gene-polymorphism-and-acetaminophen-induced-liver-injury
#16
JOURNAL ARTICLE
F Chen, Q H Li, Y J Wu, L Y Lyu, X M Xu, F Wang
Objective: To explore the association between aldehyde dehydrogenase 2 (ALDH2) gene polymorphisms and abnormal liver function-induced by acetaminophen (APAP) drugs. Methods: An ALDH2 gene knockout mouse model was constructed using CRISPR/Cas9 gene editing technology. The obtained heterozygous mice were mated with opposite sex of heterozygotes. Genomic DNA was extracted from the tail of the offspring mouse. The polymerase chain reaction (PCR) method was used to determine the ALDH2 genotype. APAP was further used to induce acute drug-induced liver injury models in wild-type and ALDH2 knockout mice...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514261/-role-of-mitochondrial-autophagy-and-the-curative-effect-of-rehmannia-glutinosa-leaves-total-glycoside-capsules-on-nucleos-t-ide-drug-induced-renal-injury
#17
JOURNAL ARTICLE
K Zhong, M M Zhang, Z X Zhu, X Liao, B F Zhang, M L Cheng
Objective: To study the curative effect of rehmannia glutinosa leaves total glycoside capsules and the role of mitochondrial autophagy on nucleos(t)ide drug-induced renal injury. Methods: Adefovir dipivoxil (ADV) was used to construct a hepatitis B virus (HBV) transgenic mouse model for renal injury. Renal function was measured in each group at one and two weeks of modeling. Mitochondrial autophagy indicators were measured at two weeks of modeling in renal tissue. Transmission electron microscopy was used to detect mitochondrial autophagy phenomena in renal tissue...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38512445/angiotensin-receptor-blockers-and-the-risk-of-suspected-drug-induced-liver-injury-a-retrospective-cohort-study-using-electronic-health-record-based-common-data-model-in-south-korea
#18
JOURNAL ARTICLE
Hyunjoo Kim, Nayeong Son, Dahee Jeong, Myungsik Yoo, In Young Choi, Wona Choi, Yeon Woong Chung, Sung Woo Ko, Seonjeong Byun, Sun Im, Da Woon Sim, Jewon Seo, Min-Gyu Kang, Jun Kyu Lee, Young-Gyun Seo, Hye-Ji An, Yeesuk Kim, Sungeu Chae, Dae Won Jun, Dong-Jin Chang, Seong Geun Kim, Siyeon Yi, Hyeon-Jong Yang, Inho Lee, Hye Jung Park, Jae-Hyun Lee, Bonggi Kim, Eunkyung Euni Lee
INTRODUCTION: Angiotensin receptor blockers are widely used antihypertensive drugs in South Korea. In 2021, the Korea Ministry of Food and Drug Safety acknowledged the need for national compensation for a drug-induced liver injury (DILI) after azilsartan use. However, little is known regarding the association between angiotensin receptor blockers and DILI. OBJECTIVE: We conducted a retrospective cohort study in incident users of angiotensin receptor blockers from a common data model database (1 January, 2017-31 December, 2021) to compare the risk of DILI among specific angiotensin receptor blockers against valsartan...
March 21, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38512019/sex-differences-in-the-susceptibility-to-valproic-acid-associated-liver-injury-in-epileptic-patients
#19
JOURNAL ARTICLE
Linfeng Ma, Dan Wang
BACKGROUND: Valproic acid has been widely used as an antiepileptic drug for several decades. Long-term valproic acid treatment is usually accompanied by liver injury. Although both men and women are susceptible to valproic acid-associated liver injury, hepatotoxicity differs between the sexes. However, the mechanisms underlying sex differences in valproic acid-associated liver injury remain unclear. METHODS: To explore potential risk factors for the susceptibility to valproic acid-associated liver injury, 231 pediatric patients with epilepsy (119 males, 112 females) were enrolled for laboratory and genetic analysis...
February 2024: Clinical Toxicology
https://read.qxmd.com/read/38510874/drug-induced-liver-injury-secondary-to-terbinafine-use
#20
Aaron Brown, Mark Potesta, Ajmal Hameed
Drug-induced liver injury (DILI) has a symptomatic profile that mimics many forms of hepatic injury. In patients presenting with symptoms suspicious of acute liver injury, it is important that clinicians effectively rule out more common causes while simultaneously maintaining a broad differential diagnosis that includes DILI. In this report, we present the case of a 41-year-old African American male who was admitted to the hospital for two weeks' duration of worsening jaundice, right upper quadrant pain, pruritus, and acholic stools after terbinafine use for an acute episode of onychomycosis...
February 2024: Curēus
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