E Hatzimichael, C Lo Nigro, L Lattanzio, N Syed, R Shah, A Dasoula, K Janczar, D Vivenza, M Monteverde, M Merlano, A Papoudou-Bai, M Bai, P Schmid, J Stebbing, M Bower, M J S Dyer, L E Karran, C ElguetaKarstegl, P J Farrell, A Thompson, E Briasoulis, T Crook
BACKGROUND: Prolyl hydroxylation is a post-translational modification that affects the structure, stability and function of proteins including collagen by catalysing hydroxylation of proline to hydroxyproline through action of collagen prolyl hydroxylases3 (C-P3H) and 4 (C-P4H). Three C-P3Hs (nomenclature was amended according to approval by the HGNC symbols and names at https://www.genenames.org/ and Entrez database at https://www.ncbi.nlm.nih.gov/gene) leucineproline-enriched proteoglycan (leprecan) 1 (Lepre1), leprecan-like 1 (Leprel1), leprecan-like 2 (Leprel2) and two paralogs Cartilage-Related Protein (CRTAP) and leprecan-like 4 (Leprel4) are found in humans...
October 9, 2012: British Journal of Cancer