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Her 2 positive Breast cancer

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https://www.readbyqxmd.com/read/29785153/prevalence-of-deleterious-mutations-among-patients-with-breast-cancer-referred-for-multigene-panel-testing-in-a-romanian-population
#1
Iulian Gabriel Goidescu, Gabriela Caracostea, Dan Tudor Eniu, Florin Vasile Stamatian
Aim: Multigene panel testing for Hereditary Breast and Ovarian Cancer (HBOC) using next generation sequencing is becoming more common in medical care.We report our experience regarding deleterious mutations of high and moderate-risk breast cancer genes (BRCA1/2, TP53, STK11, CDH1, PTEN, PALB2, CHEK2, ATM), as well as more recently identified cancer genes, many of which have increased risk but less well-defined penetrance. Methods: Genetic testing was performed in 130 consecutive cases with breast cancer referred to our clinic for surgical evaluation and who met the 2016 National Comprehensive Cancer Network (NCCN) criteria for genetic testing...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29785116/myopathy-due-to-hmgcr-antibodies-in-adult-mimicking-muscular-dystrophy-associated-with-cancer-and-statin-exposure-narrative-review-of-the-literature-case-report
#2
Alzira Alves de Siqueira Carvalho, Vinicius Gomes da Silva, Edmar Zanoteli, David Feder
Necrotizing autoimmune myopathy is characterized by predominant muscle fiber necrosis and regeneration with little or no inflammation. We describe a 58-year-old woman with previous breast cancer and statin use who complained of rapidly progressive weakness of lower limbs without pain, making walking, running and climbing stairs difficult. The creatine kinase level was 2,843 U/L, and muscle biopsy showed a dystrophic pattern. The genetic test for muscular dystrophies was negative and for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase was positive...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29783652/pituitary-gonadal-thyroid-hormones-and-endocrine-disruptors-in-pre-and-postmenopausal-nigerian-women-with-er-pr-and-her-2-positive-and-negative-breast-cancers
#3
Olulope Ajayi, Mabel Charles-Davies, John Anetor, Adeyinka Ademola
Breast cancer is broadly sub-divided into hormone responsive and non-hormone responsive subtypes. Estradiol has been associated with hormone responsive breast cancers. There is, however, a paucity of information on the role of sex hormones, gonadotropins, and thyroid hormone in non-hormone responsive breast cancer. This study aimed to determine differences in the serum levels of sex hormones, gonadotropins, thyroid hormones, and endocrine disruptors (lead, cadmium, and arsenic) in Nigerian women with hormone responsive and non-hormone responsive breast cancers...
May 18, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29752822/germline-mutations-in-40-cancer-susceptibility-genes-among-chinese-patients-with-high-hereditary-risk-breast-cancer
#4
Junyan Li, Ruilin Jing, Hongyi Wei, Minghao Wang, Xiaowei Qi, Haoxi Liu, Jian Liu, Jianghua Ou, Weihua Jiang, Fuguo Tian, Yuan Sheng, Hengyu Li, Hong Xu, Ruishan Zhang, Aihua Guan, Ke Liu, Hongchuan Jiang, Yu Ren, Jianjun He, Weiwei Huang, Ning Liao, Xiangjun Cai, Jia Ming, Rui Ling, Yan Xu, Chunyan Hu, Jianguo Zhang, Baoliang Guo, Lizhi Ouyang, Ping Shuai, Zhenzhen Liu, Ling Zhong, Zhen Zeng, Ting Zhang, Zhaoling Xuan, Xuanni Tan, Junbin Liang, Qinwen Pan, Li Chen, Fan Zhang, Linjun Fan, Yi Zhang, Xinhua Yang, Jingbo Li, Chongjian Chen, Jun Jiang
Multigene panel testing of breast cancer predisposition genes have been extensively conducted in Europe and America, which is relatively rare in Asia however. In this study, we assessed the frequency of germline mutations in 40 cancer predisposition genes, including BRCA1 and BRCA2, among a large cohort of Chinese patients with high hereditary risk of BC. From 2015 to 2016, consecutive BC patients from 26 centers of China with high hereditary risk were recruited (n=937). Clinical information was collected and next-generation sequencing (NGS) was performed using blood samples of participants to identify germline mutations...
May 12, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29750305/alterations-in-mrna-profiles-of-trastuzumab%C3%A2-resistant-her%C3%A2-2%C3%A2-positive-breast-cancer
#5
Bin Zhao, Yang Zhao, Yan Sun, Haitao Niu, Long Sheng, Dongfang Huang, Li Li
Breast cancer is one of the most common malignancies in women. Neoadjuvant trastuzumab therapy improves the prognosis of certain Her‑2‑positive breast cancer patients, however around two‑thirds of patients with Her‑2‑positive breast cancer do not benefit from Her‑2‑targeted therapy. To investigate the key mechanisms in trastuzumab resistance, potential biomarkers for neoadjuvant trastuzumab sensitivity were investigated using the gene expression omnibus (GEO) database for mRNA microarray data of Her‑2‑positive breast cancer patients who received neoadjuvant trastuzumab therapy...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29743141/chemotherapy-patient-with-stevens-johnson-syndrome-presents-to-the-emergency-department-a-case-report
#6
Stephanie Widmer, Michele Grossman
BACKGROUND: Stevens-Johnson syndrome (SJS) is part of a continuum of severe mucocutaneous reactions, commonly thought to be triggered by certain medications. The syndrome itself is characterized by diffuse necrosis and detachment of the epidermis. CASE REPORT: This case report discusses a patient who presented to the Emergency Department with signs and symptoms of Stevens-Johnson syndrome four days after chemotherapy administration of ribociclib (Kisqali®). Ribociclib is a newly approved, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor indicated for the treatment of hormone receptor positive, human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer...
April 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29738261/the-significance-of-the-stromal-response-in-breast-cancer-an-immunohistochemical-study-of-myofibroblasts-in-primary-and-metastatic-breast-cancer
#7
Alale Roozdar, Malcolm M Hayes, Bahram Pourseyedei, Hamid Zeinalinejad, Manzumeh Shamsi Meymandi, Bahram Dabiri, Shahriar Dabiri
BACKGROUND: Gene expression profiling of breast cancer has demonstrated the importance of stromal response in determining the prognosis of invasive breast cancer. The host response to breast cancer is of increasing interest to pathologists and may be a future focus for novel pharmacological treatments. METHODS: This study describes the pattern of distribution of stromal myofibroblasts using immunostains for CD10 and smooth muscle actin (SMA) in 50 primary breast cancers and their matched nodal metastases (68...
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29731922/correlation-of-immunohistochemistry-and-fluorescence-in-situ-hybridization-for-her-2-assessment-in-breast-cancer-patients-single-centre-experience
#8
Magdalena Bogdanovska-Todorovska, Slavica Kostadinova-Kunovska, Rubens Jovanovik, Blagica Krsteska, Goran Kondov, Borislav Kondov, Gordana Petrushevska
BACKGROUND: Accurate assessment of HER-2 is imperative in selecting patients for targeted therapy. Most commonly used test methods for HER-2 are immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH). We evaluated the concordance between FISH and IHC for HER-2 in breast cancer samples using Food and Drug Administration approved tests. MATERIAL AND METHODS: Archived paraffin tissue blocks from 73 breast cancer patients were used. HER-2 immunostaining was performed using Ventana anti-HER-2 monoclonal antibody...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731666/association-of-two-foxp3-polymorphisms-with-breast-cancer-susceptibility-in-chinese-han-women
#9
Tian Tian, Meng Wang, Yi Zheng, Tielin Yang, Wenge Zhu, Hongtao Li, Shuai Lin, Kang Liu, Peng Xu, Yujiao Deng, Linghui Zhou, Zhijun Dai
Background: Forkhead box P3 ( FOXP3 ) is a key gene in the immune system which also plays a role in tumor development. This study aims to explore the association of two FOXP3 polymorphisms (rs3761548 and rs3761549) with susceptibility to breast cancer (BC). Method: A case-control study was conducted, involving 560 patients and 583 healthy individuals from the Chinese Han population. The genotypes of FOXP3 polymorphisms were detected using the Sequenom MassARRAY method...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29721370/a-pi3k-p110%C3%AE-selective-inhibitor-enhances-the-efficacy-of-anti-her2-neu-antibody-therapy-against-breast-cancer-in-mice
#10
Jae-Hyeog Choi, Ki Hyang Kim, Kug-Hwan Roh, Hana Jung, Anbok Lee, Ji-Young Lee, Joo Yeon Song, Seung Jae Park, Ilhwan Kim, Won-Sik Lee, Su-Kil Seo, Il-Whan Choi, Yang-Xin Fu, Sung Su Yea, SaeGwang Park
Combination therapies with phosphoinositide 3-kinase (PI3K) inhibitors and trastuzumab (anti-human epidermal growth factor receptor [HER]2/neu antibody) are effective against HER2+ breast cancer. Isoform-selective PI3K inhibitors elicit anti-tumor immune responses that are distinct from those induced by inhibitors of class I PI3K isoforms (pan-PI3K inhibitors). The present study investigated the therapeutic effect and potential for stimulating anti-tumor immunity of combined therapy with an anti-HER2/neu antibody and pan-PI3K inhibitor (GDC-0941) or a PI3K p110α isoform-selective inhibitor (A66) in mouse models of breast cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29719409/prediction-of-tumor-mutation-burden-in-breast-cancer-based-on-the-expression-of-er-pr-her-2-and-ki-67
#11
Junnan Xu, Xiangyu Guo, Mingxi Jing, Tao Sun
Objective: Cancer immunoediting is the process of eliminating highly immunogenic tumor cells by somatic evolution and protecting the host from tumor development in the host immune system. Frequencies of somatic mutations or tumor mutation burden (TMB) were associated with immunogenicity of breast cancer. This study aimed to predict the level of TMB in patients with breast cancer by the expression of estrogen (ER), progesterone (PR), HER-2, and Ki-67, thereby anticipating the prognosis of patients and the possible response to immunotherapy...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29706855/actively-targeted-deep-tissue-imaging-and-photothermal-chemo-therapy-of-breast-cancer-by-antibody-functionalized-drug-loaded-x-ray-responsive-bismuth-sulfide-mesoporous-silica-core-shell-nanoparticles
#12
Lihua Li, Yao Lu, Chunyan Jiang, Ye Zhu, Xianfeng Yang, Xiaoming Hu, Zefeng Lin, Yu Zhang, Mingying Peng, Hong Xia, Chuanbin Mao
A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (Bi2 S3 @ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like Bi2 S3 NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin...
January 31, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29706375/balixafortide-plus-eribulin-in-her2-negative-metastatic-breast-cancer-a-phase-1-single-arm-dose-escalation-trial
#13
Sonia Pernas, Miguel Martin, Peter A Kaufman, Marta Gil-Martin, Patricia Gomez Pardo, Sara Lopez-Tarruella, Luis Manso, Eva Ciruelos, Jose Alejandro Perez-Fidalgo, Cristina Hernando, Foluso O Ademuyiwa, Katherine Weilbaecher, Ingrid Mayer, Timothy J Pluard, Maria Martinez Garcia, Linda Vahdat, Jose Perez-Garcia, Achim Wach, Debra Barker, Samson Fung, Barbara Romagnoli, Javier Cortes
BACKGROUND: The C-X-C chemokine receptor type 4 (CXCR4)-stromal cell-derived factor-1α (SDF-1α) axis regulates function and trafficking of immune cells and the tumour microenvironment. CXCR4 antagonists have been shown to enhance the activity of different anticancer treatments in preclinical models. We assessed the safety, tolerability, pharmacokinetics, and preliminary phase 1 activity of the CXCR4 antagonist, balixafortide, in combination with eribulin chemotherapy in patients with heavily pretreated, relapsed metastatic breast cancer...
April 26, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29700127/-18-f-alfatide-ii-pet-ct-for-identification-of-breast-cancer-a-preliminary-clinical-study
#14
Jiang Wu, Shaohua Wang, Xianzhong Zhang, Zhaogang Teng, Jingjie Wang, Bryant Yung, Gang Niu, Hong Zhu, Guangming Lu, Xiaoyuan Chen
18 F-Alfatide II has been proven to have excellent clinical translational potential. In this study, we investigated 18 F-Alfatide II for identifying breast cancer and compared the performances between 18 F-Alfatide II and 18 F-FDG. Methods: Forty-four female patients suspected of primary breast cancer were recruited. PET/CT images using 18 F-Alfatide II and 18 F-FDG were acquired within seven days. Tracer uptakes in breast lesions were evaluated by visual analysis, semiquantitative analysis with maximum standardized uptake value (SUVmax ) and mean standardized uptake value (SUVmean)...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#15
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690797/atezolizumab-for-the-treatment-of-breast-cancer
#16
Debora Basile, Giacomo Pelizzari, Maria Grazia Vitale, Camilla Lisanti, Marika Cinausero, Donatella Iacono, Fabio Puglisi
Breast cancer (BC) is the most common cancer diagnosed among women. The development of new personalized therapeutic strategies has reshaped the landscape in this field. However, BC is still the first cause of death among women. Interestingly, several preclinical studies and some clinical evidences are focused their attention on the role of immune system and immunotherapy on cancer control, also in BC. Areas covered: Usually, BC has been considered a not immunogenic tumor for its low mutational load. However, recent studies have evidenced that some subtypes, triple negative and HER-2 positive BC, are 'hot' tumors, thus more immunogenic...
May 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29682102/expression-of-pentose-phosphate-pathway-related-proteins-in-breast-cancer
#17
Junjeong Choi, Eun-Sol Kim, Ja Seung Koo
Purpose: The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods: Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers...
2018: Disease Markers
https://www.readbyqxmd.com/read/29679553/potential-diagnostic-role-of-circulating-mirnas-in-breast-cancer-implications-on-clinicopathological-characters
#18
Menha Swellam, Hekmat M El Magdoub, Naglaa M Hassan, Mona M Hefny, Mohamed Emam Sobeih
BACKGROUND: Circulating miRNAs are stable in body fluids and resembles their levels in cancer tissue/cells. They have been expressed in many cancers among them is breast cancer. Authors aimed to investigate the expression level of three circulating oncomiRNAs (miRNA-21, miRNA-222 and miRNA-373) in serum samples as a minimally non-invasive method for early detection of breast cancer, and study their relation with clinicopathological characters. METHODS: MiRNAs expression levels were determined using quantitative real-time polymerase chain reaction (qPCR) in serum samples from three groups: primary breast cancer patients (n = 137), benign breast lesion patients (n = 60), and healthy individuals as control group (n = 38)...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29665663/-analysis-of-neoadjuvant-docetaxel-carboplatin-and-trastuzumab-tch-in-her-2-positive-breast-cancer
#19
L Xu, J M Ye, S N Zhu, J Y Zhao, L Xin, Y J Cheng, Q Liu, H Zhang, S Zhang, X N Duan, Y H Liu
Objective: To analyze docetaxel (T) and carboplatin (C) combined with trastuzumab (H) -TCH regimen as neoadjuvant systemic therapy in early breast cancer patients with human epidermal growth factor receptor 2 (HER-2) positive. Methods: From January 2008 to December 2014, the data of patients diagnosed as early breast cancer in Breast Disease Center of Peking University First Hospital were retrospective reviewed. The data of patients with HER-2 positive conducted TCH neoadjuvant therapy and surgery, and with the complete clinicopathological information were analyzed...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29620140/diagnostic-and-prognostic-values-of-contrast%C3%A2-enhanced-ultrasound-combined-with-diffusion%C3%A2-weighted-magnetic-resonance-imaging-in-different-subtypes-of-breast-cancer
#20
Gui-Feng Liu, Zong-Qiang Wang, Shu-Hua Zhang, Xue-Feng Li, Lin Liu, Ying-Ying Miao, Shao-Nan Yu
The present study aimed to investigate the diagnostic and prognostic values of contrast‑enhanced ultrasound (CEUS) combined with diffusion‑weighted magnetic resonance imaging (DW‑MRI) in different subtypes of breast cancer (BC). CEUS and DW‑MRI were conducted in 232 patients with BC prior to surgical treatment. Patients were categorized as having the luminal A subtype, the luminal B subtype, triple‑negative subtype or the human epidermal growth factor receptor 2 (Her‑2)‑positive subtype according to their expression of the estrogen receptor (ER), progesterone receptor (PR) and Her‑2, as detected by immunohistochemistry...
March 27, 2018: International Journal of Molecular Medicine
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