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Cefuroxime

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https://www.readbyqxmd.com/read/27917708/synthesis-spectroscopic-characterization-and-antimicrobial-activities-of-benzoxazolone-derivatives
#1
Nida Iqbal Siddiqui, Muhammad Ali Versiani, Khurshid Jawaid, Maryam Shafique, Abdul Hameed, Nida Ambreen, Aneela Karim, Khalid Mohammed Khan
: : Background: Pathogenic microbial diseases are now the key virulence in our daily life. Significant research has been carried out in order to trigger the bacterial infections. Amongst the organic molecules, oxazolone and derivatives were found to have excellent bioactivities including antimicrobial activities. METHODS: By keeping in mind the considerable antimicrobial activities of class benzoxazolones, a series of benzoxazolone derivatives 3-16 have been synthesized...
December 5, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27906556/combination-effect-of-cefuroxime-and-levofloxacin-against-bacteria-isolated-from-the-healthy-conjunctival-sac-and-endophthalmitis-cases-using-a-fractional-inhibitory-concentration-index
#2
Takashi Suzuki, Toshihiro Yamamoto, Tomohiko Torikai, Yuichi Ohashi
PURPOSE: Intracameral cefuroxime (CXM) and antibiotic eye drops such as fluoroquinolone are widely used for preventing endophthalmitis after cataract surgery. However, few reports are available regarding their interactions. This study was conducted to examine the in vitro interaction of CXM and levofloxacin (LVFX) against bacterial isolates from the healthy conjunctival sac before cataract surgery and from endophthalmitis cases. METHODS: The activity of each drug was determined using a broth dilution method...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27898714/comparable-effectiveness-of-first-week-treatment-with-anti-staphylococcal-penicillin-versus-cephalosporin-in-methicillin-sensitive-staphylococcus-aureus-bacteremia-a-propensity-score-adjusted-retrospective-study
#3
Erik Forsblom, Eeva Ruotsalainen, Asko Järvinen
: The objective was to compare the prognostic impact of first week treatment with anti-staphylococcal penicillin (ASP) versus cephalosporin in methicillin-sensitive Staphylococcus aureus bacteremia (MS-SAB). Altogether 580 patients were retrospectively followed and categorized according to first week treatment; 84% (488) received ASP (cloxacillin) and 16% (92) cephalosporin (cefuroxime or ceftriaxone). SAB management was optimized with formal bedside infectious disease specialist consultation in 88%, deep infection foci diagnosed in 77% and adjunctive rifampicin therapy given to 61% of patients...
2016: PloS One
https://www.readbyqxmd.com/read/27889501/endophthalmitis-after-clear-corneal-cataract-surgery-outcomes-over-two-decades
#4
Nicolas A Yannuzzi, Nancy Si, Nidhi Relhan, Ajay E Kuriyan, Thomas A Albini, Audina M Berrocal, Janet L Davis, William E Smiddy, Justin Townsend, Darlene Miller, Harry W Flynn
PURPOSE: To report the clinical features, causative organisms, and visual acuity (VA) outcomes associated with acute-onset endophthalmitis after clear corneal cataract surgery over the past two decades. DESIGN: Retrospective case series. METHODS: Clinical and microbiology records were reviewed for 63 eyes of 63 patients who presented to a tertiary referral center between 2006 and 2015 with culture-positive endophthalmitis occurring within 6 weeks of clear corneal cataract surgery...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27888174/phenotypic-and-antibiogram-pattern-of-v-cholerae-isolates-from-a-tertiary-care-hospital-in-mumbai-during-2004-2013-a-retrospective-cross-sectional-study
#5
V Torane, S Kuyare, G Nataraj, P Mehta, S Dutta, B Sarkar
OBJECTIVES: Cholera is a major gastroenteric disease with reports on fluctuation and resistance. Hence, the objective is to determine the trend in seasonality, resistance pattern, prevalent biotypes, serotypes and phage types between 2004 and 2013 among Vibrio cholerae isolates. DESIGN: A retrospective cross-sectional study. SETTINGS: A single-centre study was carried out at a tertiary care hospital in a metropolitan city (Mumbai) of a developing country (India)...
November 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27878620/the-role-of-single-shot-metronidazole-in-the-prevention-of-clostridium-difficile-infection-following-ileostomy-reversal-surgery
#6
Roland Fernandes, Paul Robinson, Karan Rangarajan, Sophie Scott, Laura Angco
PURPOSE: Symptomatic infection with Clostridium difficile is strongly linked to antibiotic use and rates are higher for colorectal surgery. In February 2015, trust policy for antibiotic prophylaxis of ileostomy reversal surgery was changed from three doses of metronidazole plus cefuroxime to single-dose metronidazole, in a bid to reduce rates of Clostridium difficile infection. METHODS: A retrospective cohort study was conducted at a single, large hospital trust between February 2014 and February 2016, before and after change in antimicrobial policy...
November 23, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27867375/ceftriaxone-pulse-dosing-fails-to-eradicate-biofilm-like-microcolony-b-burgdorferi-persisters-which-are-sterilized-by-daptomycin-doxycycline-cefuroxime-without-pulse-dosing
#7
Jie Feng, Shuo Zhang, Wanliang Shi, Ying Zhang
Although the majority of Lyme disease patients can be cured, at least 10-20% of the patients continue to suffer from persisting symptoms such as fatigue, muscular and joint pain, and neurologic impairment after standard 2-4 week antibiotic treatment. While the causes for this post-treatment Lyme disease symptoms are unclear, one possibility is due to Borrelia burgdorferi persisters that are not effectively killed by current antibiotics such as doxycycline or amoxicillin used to treat Lyme disease. A previous study showed that four rounds of ceftriaxone pulse dosing treatment eradicated B...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27845294/-antibiotic-sensitivity-resistance-of-microbial-strains-isolated-in-traumatological-department
#8
N Avazashvili, P Imnadze, I Mchedlishvili, Kh Gachechiladze
In this article, there are given data of study for antibiotic sensitivity/resistance of gram-positive and gram-negative representatives of different microbial species, isolated from patients after primary hip replacement and osteosynthesis of long bones, which had post operative infectious complications, and also isolated from samples of traumatology department environment. Identification of sensitivity/resistance to antibiotics was performed with use of two methods - disc diffusion and serial dilution on solid nutrient media...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27843267/bacteriology-of-urine-specimens-obtained-from-men-with-symptomatic-benign-prostatic-hyperplasia
#9
Jude Orumuah Agbugui, E O Obarisiagbon, I I Osaigbovo
BACKGROUND: Bacteriuria and urinary tract infections are common sequelae of benign prostatic hyperplasia (BPH). Thus, the knowledge of urine bacteriology in men with symptomatic BPH in our environment may play a complementary role in management. OBJECTIVES: To determine the incidence of bacteriuria and the antibiotic sensitivity pattern of bacterial isolates in cultured urine samples of men with symptomatic BPH. PATIENTS AND METHODS: This was a 1 year prospective study...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27834330/distribution-trends-antibiogram-pattern-of-salmonella-enterica-serovar-newport-in-india
#10
Y Kumar, N Gupta, V B Vaish, S Gupta
BACKGROUND & OBJECTIVES: Salmonellosis is a major public health concern worldwide. Besides typhoidal salmonellae, infections due to non-typhoidal serovars of Salmonella are also associated with high morbidity and mortality leading to huge economic losses. Among non-typhoidal serovars, Salmonella Newport has been reported as a major cause of foodborne infections resulting in outbreaks due to consumption of contaminated food items. Little data related to this serovar are available from India leading to the scarcity of information on the distribution trends of this important serovar in the country...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27824933/perioperative-antibiotics-to-prevent-acute-endophthalmitis-after-ophthalmic-surgery-a-systematic-review-and-meta-analysis
#11
Jinzhu Huang, Xiaofang Wang, Xiaohong Chen, Qiuyue Song, Wen Liu, Laichun Lu
BACKGROUND: Post-operative endophthalmitis is a rare and dreaded complication in ophthalmic operations because it often induces irreparable vision loss. Although many ophthalmological studies aimed at reducing the rate of endophthalmitis have been performed around the world, controversy continues to surround some issues, including the choice of antimicrobials and their route of administration, duration and timing. The aim of this study is to investigate some of these unresolved issues...
2016: PloS One
https://www.readbyqxmd.com/read/27822762/clinical-practice-audit-concerning-antimicrobial-prophylaxis-in-paediatric-neurosurgery-results-from-a-german-paediatric-oncology-unit
#12
Katja Weiss, Arne Simon, Norbert Graf, Jakob Schöpe, Joachim Oertel, Stefan Linsler
BACKGROUND: Perioperative antimicrobial prophylaxis (PAP) has been identified as an important target for internal audits, concerning the judicious use of antibiotics. Paediatric oncology patients with brain tumours face an increased risk of surgical site infection (SSI) after neurosurgery and receive routine PAP in this setting. PATIENTS AND METHODS: All patients younger than 18 years admitted to the paediatric oncology centre (POC) with a neurosurgical intervention...
November 7, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27793818/randomised-controlled-trial-of-prophylactic-antibiotic-treatment-for-the-prevention-of-endophthalmitis-after-open-globe-injury-at-groote-schuur-hospital
#13
N Du Toit, S Mustak, C Cook
BACKGROUND/AIMS: Most post-traumatic acute infectious endophthalmitis occur within a week of open globe trauma, necessitating early antibiotic prophylaxis. There are few randomised studies that demonstrate the benefits of prophylactic antibiotics. This randomised controlled non-inferiority trial was aimed at determining the incidence of post-traumatic endophthalmitis using established intravenous/oral prophylaxis and comparing this to the incidence using oral antibiotics only. METHODS: All adult patients admitted with open globe injury were included...
October 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27759360/a-relook-of-cefuroxime-in-community-infections-an-option-still-beneficial
#14
V R Badhwar, S Ganapathy, P P Prabhudesai, N K Tulara, A Y Varaiya, D Vyas
In community and family practice, infections are a common OPD presentation. In the management of common bacterial infections seen in community especially RTI, UTI, SSTI; cefuroxime a second generation cephalosporin with a broad spectrum of activity can be used for empirical treatment. To know current place of cefuroxime in the management of infections, physicians, surgeons, microbiologist, chest physician, gynecologist and pediatrician came together to discuss and debate their experience with cefuroxime and its place in today's world...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27737742/coupling-data-mining-and-laboratory-experiments-to-discover-drug-interactions-causing-qt-prolongation
#15
Tal Lorberbaum, Kevin J Sampson, Jeremy B Chang, Vivek Iyer, Raymond L Woosley, Robert S Kass, Nicholas P Tatonetti
BACKGROUND: QT interval-prolonging drug-drug interactions (QT-DDIs) may increase the risk of life-threatening arrhythmia. Despite guidelines for testing from regulatory agencies, these interactions are usually discovered after drugs are marketed and may go undiscovered for years. OBJECTIVES: Using a combination of adverse event reports, electronic health records (EHR), and laboratory experiments, the goal of this study was to develop a data-driven pipeline for discovering QT-DDIs...
October 18, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27714984/quantification-of-three-beta-lactam-antibiotics-in-breast-milk-and-human-plasma-by-hydrophilic-interaction-liquid-chromatography-positive-ion-electrospray-ionization-mass-spectrometry
#16
Evaggelos Kiriazopoulos, Sabina Zaharaki, Ariadni Vonaparti, Panagiota Vourna, Eirini Panteri-Petratou, Dimitra Gennimata, Kara Lombardo, Irene Panderi
The use of cephalosporins during breast feeding raises several issues, including the risk of drug exposure through breast milk for the infant. In this article a hydrophilic interaction liquid chromatography/ positive ion electrospray mass spectrometric assay (HILIC/ESI-MS) was developed for the quantitation of cefuroxime, cefoxitin and cefazolin in breast milk and human plasma. The assay was based on the use of small sample size, 25 μL of biological samples, following acetonitrile precipitation of proteins and filtration that enabled injection into the HILIC/ESI-MS system...
October 7, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27697250/endophthalmitis-after-cataract-surgery-despite-intracameral-antibiotic-prophylaxis-with-licensed-cefuroxime
#17
Charles Mesnard, Laurence Beral, Rabih Hage, Harold Merle, Selim Farès, Thierry David
PURPOSE: To report a case series of post-phacoemulsification endophthalmitis despite antibiotic prophylaxis with an intracameral injection of a licensed cefuroxime formulation (Aprokam). SETTING: University Hospitals of Pointe-à-Pitre, Guadeloupe, and Fort-de-France, Martinique, French West Indies. DESIGN: Retrospective case series. METHODS: Patients who had cataract surgery with licensed cefuroxime prophylaxis between March 1, 2013, and July 31, 2015, and developed endophthalmitis were included...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27697249/ocular-flora-and-their-antibiotic-susceptibility-in-patients-having-cataract%C3%A2-surgery-in-italy
#18
Vincenzo Papa, Anna Rita Blanco, Marcello Santocono
PURPOSE: To characterize the ocular flora in a consecutive group of patients having cataract surgery and to determine the antibiotic susceptibility profile of isolates to several ophthalmic antibiotics. SETTING: Hospital Di Stefano, Catania, Italy. DESIGN: Observational case series. METHODS: Conjunctival and eyelid cultures from patients were obtained 14 days before surgery and, if positive, repeated the day of the surgery...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27692104/effect-of-cefazolin-and-cefuroxime-on-fracture-healing-in-rats
#19
Moises Natividad-Pedreño, Alberto Nuñez-Chia, Nuria Cobo-Valenzuela, Tomas Alcantara-Martos, Maria T Carrascal, Alberto D Delgado-Martinez
OBJECTIVE: To determine the effect of cefazolin and cefuroxime (the two most commonly used beta lactam antibiotics) at therapeutic doses in fracture healing in an animal model. MATERIAL AND METHODS: 75 adult male wistar rats (3months old) were selected. They were divided into three groups of 25 animals each (placebo, cefazolin and cefuroxime). A closed fracture was made in the middle third of the right femur of each rat and fixed with a Kirschner wire. Each group was treated with either saline (placebo), cefazolin or cefuroxime at therapeutic doses during fracture healing...
September 2016: Injury
https://www.readbyqxmd.com/read/27629738/the-efficacy-of-perioperative-antibiotic-therapy-in-tonsillectomy-patients
#20
Krzysztof Orłowski, Grażyna Lisowska, Hanna Misiołek, Zbigniew Paluch, Maciej Misiołek
BACKGROUND: While the results of early research suggested that perioperative antibiotic prophylaxis in tonsillectomy patients is associated with many benefits, these data were not confirmed by further studies and meta-analyses. OBJECTIVES: The aim of this study was to investigate the usefulness and efficacy of antibiotic monotherapy in the healing of surgical wounds of patients undergoing bilateral resection of the palatine tonsils, based on an analysis of selected objective and subjective characteristics of wound healing during the postoperative period...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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