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Min-Suk Yang, Dong-Yoon Kang, Bomi Seo, Hye Jung Park, So-Young Park, Mi-Yeong Kim, Kyung Hee Park, So-My Koo, Young-Hee Nam, Sujeong Kim, Jae-Woo Jung, Tae-Bum Kim, Gwang Cheon Jang, Hyeon-Jong Yang, Young-Min Ahn, Jung-Won Park, Hye-Ryun Kang
BACKGROUND: Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin-induced anaphylaxis and evaluate the clinical efficacy of screening skin tests. METHODS: In this retrospective cohort study, we obtained information on total cephalosporin use and cephalosporin-induced anaphylaxis in intravenous cephalosporin recipients in 12 general hospitals between 2013 and 2015...
March 8, 2018: Allergy
Alexander K C Leung, Benjamin Barankin, Kin Fon Leong
BACKGROUND: Staphylococcal-scalded skin syndrome (SSSS), also known as Ritter disease, is a potentially life-threatening disorder and a pediatric emergency. Early diagnosis and treatment is imperative to reduce the morbidity and mortality of this condition. The purpose of this article is to familiarize physicians with the evaluation, diagnosis, and treatment of SSSS. DATA SOURCES: A PubMed search was completed in Clinical Queries using the key terms "Staphylococcal scalded skin syndrome" and "Ritter disease"...
March 5, 2018: World Journal of Pediatrics: WJP
Chengguo Zuo, Lan Mi, Dan Ye, Xinxing Guo, Hui Xiao, Mingxing Wu, Xing Liu
PURPOSE: To determine the clinical characteristics and outcomes of patients with toxic retinopathy after phacoemulsification and intraocular lens implantation when the correct cefuroxime dilution is administered. SETTING: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. DESIGN: Prospective case series. METHODS: Patients developing toxic retinopathy after phacoemulsification between January 2016 and April 2017 were observed...
January 2018: Journal of Cataract and Refractive Surgery
Maria Daniel, Hania Szajewska, Małgorzata Pańczyk-Tomaszewska
INTRODUCTION: The optimal duration of antibiotic therapy in children with febrile urinary tract infections (UTIs) is still a matter of debate. Current guidelines recommend treating children with febrile UTIs with antimicrobials for 7 to 14 days. We aim to compare the efficacy and safety of 7-day versus 10-day course of oral or sequence therapy (intravenous with a switch to oral) with cefuroxime/cefuroxime axetil for febrile UTIs in children. METHODS AND ANALYSIS: A non-inferiority, double-blind, randomised, controlled trial will be conducted...
March 2, 2018: BMJ Open
Nilüfer Bayrak
This article presents a complete and detailed study of synthesis, structural characterization, and possible applications of a new family of azanaphthoquinones as antimicrobial agents. A series of (alkoxy)phenylamino-chloro-2-methylquinoline-5,8-dione derivatives (3a-j, 3a', 3e') was prepared by regioselective nucleophilic substitution of 6,7-dichloro-2-methylquinoline-5,8-dione (1) with (alkoxy)arylamines (2) in the presence of CeCl3 ·7H2 O. In vitro antimicrobial study of the newly synthesized compounds was evaluated in a panel of three fungi and seven bacterial strains (three Gram-positive and four Gram-negative bacteria)...
February 23, 2018: Chemistry Central Journal
Chenyang Li, Greta Gölz, Thomas Alter, Andrea Barac, Stefan Hertwig, Carolin Riedel
Yersinia enterocolitica is a zoonotic enteropathogenic bacterium that can cause acute gastroenteritis and mesenteric lymphadenitis. Although Y. enterocolitica is common in animals, food, and the environment, the reservoirs and transmission routes of this pathogen are still not fully understood. The aim of our study was to determine the prevalence of Y. enterocolitica in seafood in Germany, because only limited data are available on that topic. Seafood samples were purchased from retail shops in Berlin, Germany and examined for the presence of Y...
February 23, 2018: Journal of Food Protection
Fikret Türkan, Zübeyir Huyut, Parham Taslimi, İlhami Gülçin
In this paper, the in vivo effects of some antibiotics including cefazolin, cefuroxime, and cefoperazon, on the activity of the carbonic anhydrase enzyme (CA) in heart, brain, eye, liver, and kidney tissues of rats were evaluated. For this purpose, 16 different groups, which each containing six rats (n = 6), were formed (control group, cefazolin groups, cefuroxime groups, and cefoperazon groups). The rats were necropsied 60 min after the intraperitoneal injection of the chemicals into the rats. The CA activities were measured for each tissue using esterase activity methods...
February 19, 2018: Journal of Biochemical and Molecular Toxicology
Sorin Claudiu Man, Valentina Sas, Cristina Schnell, Camelia Florea, Adelina Ţuţu, Ariana Szilágyi, Sergiu Belenes, Amalia Hebriştean, Anca Bonaţ, Claudia Cladovan, Cornel Aldea
Background and aims: Community-acquired pneumonia (CAP) is a both common and serious childhood infection. Antibiotic treatment guidelines help to reduce inadequate antibiotics prescriptions. Methods: We conducted a retrospective study at the Clinical Emergency Hospital for Children, 3rd Pediatric Clinic, Cluj-Napoca and Dr. Gavril Curteanu Clinical City Hospital, in Oradea. All patients discharged with a diagnosis of CAP between December 1, 2014 and February 28, 2015, were included in the study...
2018: Clujul Medical (1957)
E Friling, P Montan
BACKGROUND: Intracameral cefuroxime as prophylaxis against postoperative endophthalmitis (POE) following cataract surgery was introduced in 1996 at St Erik Eye Hospital. Soon after the introduction of intracameral cefuroxime the rate of POE fell dramatically and a shift in the aetiology was noticed. AIM: To analyse bacteriology and susceptibility to cefuroxime before and after the introduction. METHODS: All culture-proven endophthalmitis cases at St Erik Eye Hospital after cataract surgery performed over a 20-year period were included in a retrospective observational study...
February 9, 2018: Journal of Hospital Infection
Jan K Adamski, Björn B Jäschke, Raija S Uusitalo-Seppälä, Kalle V J Moilanen, Antti V Pehkonen, Wojciech Weigl
Development of the extreme form of hypothyroidism defined as myxedema is very rare. Acute symptoms and their management have been described in detail previously. However, not much attention has been devoted to therapeutic challenges that are faced in the recovery phase of the treatment, especially pertaining to the gastrointestinal system. The link between myxedema and the appearance of severe Clostridium difficile infection (CDI) has not been established so far. A 61-year-old woman with no significant medical record was admitted to hospital because of infected heel pressure and thyroid dysfunction...
September 2017: Case Reports in Gastroenterology
Magdalena Absmaier, Tilo Biedermann, Knut Brockow
No abstract text is available yet for this article.
February 8, 2018: Journal of Allergy and Clinical Immunology in Practice
Appiah-Korang Labi, Noah Obeng-Nkrumah, Edmund Tetteh Nartey, Stephanie Bjerrum, Nii Armah Adu-Aryee, Yaw Adjei Ofori-Adjei, Alfred E Yawson, Mercy J Newman
Background: The global rise and spread of antibiotic resistance is limiting the usefulness of antibiotics in the prevention and treatment of infectious diseases. The use of antibiotic stewardship programs guided by local data on prescribing practices is a useful strategy to control and reduce antibiotic resistance. Our objective in this study was to determine the prevalence and indications for use of antibiotics at the Korle-Bu Teaching Hospital Accra, Ghana. Methods: An antibiotic point prevalence survey was conducted among inpatients of the Korle-Bu Teaching Hospital between February and March 2016...
2018: Antimicrobial Resistance and Infection Control
Antonino Romano, Rocco Luigi Valluzzi, Cristiano Caruso, Michela Maggioletti, Donato Quaratino, Francesco Gaeta
BACKGROUND: Studies performed since 1990 on samples of at least 30 subjects with a documented IgE-mediated hypersensitivity to penicillins have found a rate of positive responses to allergy tests with cephalosporins ranging from 0% to 27%. OBJECTIVE: We sought to assess the cross-reactivity with cephalosporins and evaluate the possibility of using cephalosporins in penicillin-allergic subjects. METHOD: We conducted a prospective study of 252 consecutive subjects who had suffered 319 immediate reactions (mostly anaphylaxis) to penicillins and had positive skin tests to at least one penicillin reagent...
February 2, 2018: Journal of Allergy and Clinical Immunology in Practice
Jun Wang, Lijiao He, Jintong Sha, Haobo Zhu, Liqu Huang, Xiaojiang Zhu, Juan Dong, Guogen Li, Zheng Ge, Rugang Lu, Geng Ma, Yaqi Shi, Yunfei Guo
BACKGROUND: Urinary tract infections (UTIs) are one of most common pediatric infections. The aim of this study was to investigate the etiology and antimicrobial resistance patterns of hospitalized children in our center. METHODS: We conducted a retrospective, descriptive study of all UTIs from January 1, 2013 to November 31, 2016 in children discharged from Nanjing Children's Hospital. The isolated pathogens and their resistance patterns were examined from midstream urine culture...
February 2, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Hélène Cornillier, Bruno Giraudeau, Stéphane Munck, Florence Hacard, Annie-Pierre Jonville-Bera, Gwenaëlle d'Acremont, Bach-Nga Pham, Annabel Maruani
BACKGROUND: Chronic spontaneous urticaria (CSU) is not frequent in children. Management guidelines have been developed for adults and randomized controlled trials (RCTs) included teenagers aged 12 to 18, but data for children under age 12 are limited. We performed a systematic review to assess comorbidities in children < 12 years old with CSU and the efficacy and safety of treatments. METHODS: We searched for original articles of epidemiologic and treatment data in children < 12 years old with CSU that were published from 2005 to July 2016 in MEDLINE, EMBASE, CENTRAL and LILACS...
February 2, 2018: Pediatric Allergy and Immunology
Yu Zhou, Xuhui Zhu, Hongyan Hou, Yanfang Lu, Jing Yu, Lie Mao, Liyan Mao, Ziyong Sun
BACKGROUND: Diarrhea is the leading infectious cause of childhood morbidity and mortality. Among bacterial agents, diarrheagenic Escherichia coli (DEC) is the major causal agent of childhood diarrhea in developing countries, particularly in children under the age of 5 years. Here, we performed a hospital-based prospective study to explore the pathotype distribution, epidemiological characteristics and antibiotic resistance patterns of DEC from < 5-year-old diarrheal children. METHODS: Between August 2015 and September 2016, 684 stool samples were collected from children (< 5 years old) with acute diarrhea...
February 1, 2018: BMC Infectious Diseases
J Gaspar-Marques, E Finelli, P C Martins, S Prates, P Leiria-Pinto
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure...
November 20, 2017: European Annals of Allergy and Clinical Immunology
Lars Helbig, Maren Bechberger, Riyadh Aldeeri, Adriana Ivanova, Patrick Haubruck, Matthias Miska, Gerhard Schmidmaier, Georg W Omlor
Purpose: Infected nonunions of the long bones belong to the most feared complications in the field of orthopedic and trauma surgery. Optimal antibiotic therapy should start early with the first revision surgery. Therefore, the aim of this study was to evaluate our peri- and postoperative antibiotic regime in context with the microbial spectrum and antibiotic resistances of patients with infected nonunions and to assess the possible impact on healing rates. Methods: We included all patients with first revision surgery during 2010-2015 due to nonunion of long bones with a clinical history of infection treated with radical debridement, local application of a gentamicin-impregnated bone cement, and systemic cefuroxime...
2018: Therapeutics and Clinical Risk Management
Sebastian Bischoff, Thomas Walter, Marlis Gerigk, Matthias Ebert, Roger Vogelmann
BACKGROUND: The aim of this study was to identify clinical risk factors for antimicrobial resistances and multidrug resistance (MDR) in urinary tract infections (UTI) in an emergency department in order to improve empirical therapy. METHODS: UTI cases from an emergency department (ED) during January 2013 and June 2015 were analyzed. Differences between patients with and without resistances towards Ciprofloxacin, Piperacillin with Tazobactam (Pip/taz), Gentamicin, Cefuroxime, Cefpodoxime and Ceftazidime were analyzed with Fisher's exact tests...
January 26, 2018: BMC Infectious Diseases
Henry D J Hogg, We Fong Siah, Arthur Okonkwo, Manjusha Narayanan, Francisco C Figueiredo
OBJECTIVES: Stenotrophomonas maltophilia is an opportunistic pathogen known to form biofilms on contact lens and case surfaces that may result in permanent visual loss in cases of microbial keratitis. Because of its multiple drug resistance and extremely low incidence, there is little consensus on treatment. We investigated the predisposing factors, management, and visual outcomes in a small case series of patients to better inform the management of this rarely reported keratitis. METHODS: Retrospective analysis of medical records was performed at a single tertiary referral center between 2011 and 2017...
January 22, 2018: Eye & Contact Lens
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