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https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#1
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29764520/investigation-of-a-typhoid-fever-epidemic-in-moyale-sub-county-kenya-2014-2015
#2
Dahabo Adi Galgallo, Zeinab Gura Roka, Waqo G Boru, Khalumi Abill, James Ransom
AIM: Typhoid fever is a vaccine-preventable bacterial disease that causes significant morbidity and mortality throughout Africa. This paper describes an upsurge of typhoid fever cases in Moyale Sub-County (MSC), Kenya, 2014-2015. METHODS: We conducted active hospital and health facility surveillance and laboratory and antimicrobial sensitivity testing for all patients presenting with headache, fever, stomach pains, diarrhea, or constipation at five MSC health facilities between December 2014 and January 2015...
May 15, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29761538/pharmacokinetics-of-cefuroxime-in-infants-and-neonates-undergoing-cardiac-surgery
#3
R Gertler, M Gruber, G Wiesner, S Grassin-Delyle, S Urien, P Tassani-Prell, K Martin
AIM: Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age. METHODS: 50 mg kg-1 CXM iv after induction were followed by 75 mg kg-1 into the CPB circuit. In 42 patients undergoing cardiac surgery 15 to 20 samples were obtained between 5 and 360 min after each dose. Total CXM concentrations were measured by high-performance liquid chromatography and a PK/PD modelling was performed...
May 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29759804/urinary-tract-infection-by-aerococcus-sanguinicola-an-emerging-opportunistic-pathogen
#4
G Jiménez-Guerra, A Lara-Oya, I Martínez-Egea, J M Navarro-Marí, J Gutiérrez-Fernández
Elderly patients with underlying urological disease have a greater risk of urinary tract infections due to uncommon pathogens. The disease caused by Aerococcus has been underestimated, but mass spectrometry could be a simple method for identifying this pathogen. In this study, we report 2 cases of urinary tract infection by Aerococcus sanguinicola. A descriptive clinical-microbiological study was conducted on the presence of A. sanguinicola causing urinary tract infections. The presence of A. sanguinicola occurred in elderly patients with previous urological disease and a significant count in urine obtained through bladder catheterisation...
May 11, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29759235/rapid-microbiological-methods-rmms-for-evaluating-the-activity-of-cephalosporin-antibiotics-employing-triphenyltetrazolium-chloride
#5
Alessandro Morais Saviano, Felipe Rebello Lourenço
Agar diffusion method has been used to evaluate antimicrobial activity since the discovery of penicillin. Nevertheless, little progress has occurred in reducing the time required to determine growth inhibition zones. The aim of this work was to develop, optimize and validate rapid microbiological methods (RMMs) for cephalosporin antibiotics using triphenyltetrazolium chloride (TTC) to reduce the incubation time of the assays. Through a factorial design in which the inoculum suspension, incubation time, and percentage of the TTC solution were varied, it was possible to validate the RMMs for cefazolin, cefuroxime, ceftriaxone, and cefepime...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29739103/bacteramia-caused-by-gardnerella-vaginalis-in-a-cesarean-section-patient
#6
Yili Chen, Xinhong Han, Penghao Guo, Han Huang, Zhongwen Wu, Kang Liao
BACKGROUND: Gardnerella vaginalis is a facultative anaerobic and small gram-variable rod bacterium. G. vaginalis, which can be transmitted through sexual contact, is the common pathogen for the feminine bacterial pathogen (BV). Here we describe a case of bacteremia in a patient after cesarean section caused by G. vaginalis in China. Case presentation: A 35-year-old woman suffered bacteremia caused by G. vaginalis after cesarean section. This patient, without evidence of polymicrobial infection, was treated with cefuroxime and had a good outcome...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29734648/bioactivity-guided-isolation-of-antimicrobial-and-antioxidant-metabolites-from-the-mushroom-tapinella-atrotomentosa
#7
Zoltán Béni, Miklós Dékány, Bernadett Kovács, Boglárka Csupor-Löffler, Zoltán Péter Zomborszki, Erika Kerekes, András Szekeres, Edit Urbán, Judit Hohmann, Attila Ványolós
Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1 ⁻ 4 . Two of the compounds are lactones—osmundalactone ( 1 ) and 5-hydroxy-hex-2-en-4-olide ( 2 )—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29731632/development-of-nanoemulsion-for-efficient-brain-parenteral-delivery-of-cefuroxime-designs-characterizations-and-pharmacokinetics
#8
Siti Norhawani Harun, Syafinaz Amin Nordin, Siti Salwa Abd Gani, Ahmad Fuad Shamsuddin, Mahiran Basri, Hamidon Bin Basri
Background and aim: Drugs that are effective against diseases in the central nervous system and reach the brain via blood must pass through the blood-brain barrier (BBB), a unique interface that protects against potential harmful molecules. This presents a major challenge in neuro-drug delivery. This study attempts to fabricate the cefuroxime-loaded nanoemulsion (CLN) to increase drug penetration into the brain when parenterally administered. Methods: The nanoemulsions were formulated using a high-pressure homogenization technique and were characterized for their physicochemical properties...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29729161/antimicrobial-susceptibility-patterns-of-escherichia-coli-in-children-and-adults-with-urinary-tract-infections
#9
Yaroslav O Mykhalko
OBJECTIVE: Introduction: Urinary tract infections (UTIs) are common pathology in children and adults that is caused mainly by Gram-negative bacteria among which Escherichia coli plays an outstanding role. UTIs treatment demands empiric antibiotic therapy and knowing of antimicrobial local susceptibility and resistance patterns is crucial for making a decision about an agent for the first line therapy. The aim of this study was to evaluate the local susceptibility patterns of uropathogenic E...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29720043/antimicrobial-stewardship-through-telemedicine-and-its-impact-on-multi-drug-resistance
#10
Rodrigo P Dos Santos, Camila H Dalmora, Stephani A Lukasewicz, Otávio Carvalho, Caroline Deutschendorf, Raquel Lima, Tiago Leitzke, Nilson C Correa, Marcelo V Gambetta
Introduction Telemedicine technologies are increasingly being incorporated into infectious disease practice. We aimed to demonstrate the impact of antimicrobial stewardship through telemedicine on bacterial resistance rates. Methods We conducted a quasi-experimental study in a 220-bed hospital in southern Brazil. An antimicrobial stewardship program incorporating the use of telemedicine was implemented. Resistance and antimicrobial consumption rates were determined and analysed using a segmented regression model...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29715477/simultaneous-retrodialysis-by-calibrator-for-rapid-in-vivo-recovery-determination-in-target-site-microdialysis
#11
Yichao Yu, Hardik Chandasana, Taran Sangari, Christoph Seubert, Hartmut Derendorf
Concentrations in the interstitial tissue space are of clinical interest for many antibiotics and can be directly measured by microdialysis. Quantitative microdialysis strongly depends on reliable recovery estimates obtained from a suitable calibrator. Cefazolin is frequently used as a prophylactic antibiotic to prevent surgical site infections. This study aimed to develop a reliable and rapid calibration technique for cefazolin microdialysis using cefuroxime as a calibrator, which is applied simultaneously in the opposite direction via retrodialysis...
April 28, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29703287/pupil-dilation-dynamics-with-an-intracameral-fixed-combination-of-mydriatics-and-anesthetic-during-cataract-surgery
#12
Frederic Chiambaretta, Uwe Pleyer, Anders Behndig, Pierre-Jean Pisella, Erik Mertens, Antonio Limao, Francesco Fasce, Joaquin Fernandez, Salah-Eddine Benmoussa, Marc Labetoulle, Beatrice Cochener
PURPOSE: To compare the pupil dynamics of an intracameral combination of 2 mydriatics and 1 anesthetic (Mydrane) to a standard topical regimen for cataract surgery. SETTING: Sixty-two centers in Europe and 6 centers in Algeria. DESIGN: Prospective case series. METHODS: Pupil size measurements were performed in 2 randomized studies (phase 2 and phase 3) under masked conditions (recorded videography, masked reading center)...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29701728/synthesis-and-antibacterial-activity-of-new-thiazolidine-2-4-dione-based-chlorophenylthiosemicarbazone-hybrids
#13
Nazar Trotsko, Urszula Kosikowska, Agata Paneth, Tomasz Plech, Anna Malm, Monika Wujec
Series of new thiazolidine-2,4-dione-based chlorophenylthiosemicarbazone hybrids ( 17 ⁻ 40 ) were synthesized by the reaction of condensation chlorophenylthiosemicarbazides with formylphenyl 2-(2,4-dioxothiazolidin-5-yl/ylidene)acetates. New compounds were tested on reference strains of Gram-positive and Gram-negative bacteria. The antibacterial activity of target compounds was determined by broth dilution method. Most active compounds possess minimum inhibitory concentration (MIC) = 3.91 mg/L. These compounds were non-toxic at concentrations close to their antibacterial effect...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29684574/genetic-characterization-of-class-i-integrons-among-multidrug-resistant-salmonella-serovars-in-broiler-chicken-farms
#14
Rasha M Elkenany, Abdelfattah H Eladl, Reham A El-Shafei
BACKGROUND: The antibiotic resistance of Salmonella serovars is recorded and the integrons play an important role in the dissemination of antibiotic resistance genes in bacteria. Little literatures are available on the recognition of integrons in isolated Salmonella from broiler chickens. OBJECTIVES: In this study, antibiotic resistance and characterization of class 1 (Cls1) integrons among Multidrug resistance serovars of Salmonella enterica in broiler chicken farms were performed...
April 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29682477/identification-of-extended-spectrum-beta-lactamases-ampc-and-carbapenemase-production-among-isolates-of-escherichia-coli-in-north-indian-tertiary-care-centre
#15
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli , helps clinician to rationalize the choice of antibiotics. However, there is a lack of simple and effective method for simultaneous identification of these beta lactamases. Aim: To determine the concurrent production of beta lactamases using twelve disc method on E. coli isolates. Materials and Methods: A total of 200 multidrug resistant E...
April 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29680695/microbiological-quality-and-antimicrobial-resistance-characterization-of-salmonella-spp-in-fresh-milk-value-chains-in-ghana
#16
Angela Parry-Hanson Kunadu, Mark Holmes, Eric L Miller, Andrew J Grant
Consumer perception of poor hygiene of fresh milk products is a major barrier to promotion of milk consumption as an intervention to alleviate the burden of malnutrition in Ghana. Fresh milk is retailed raw, boiled, or processed into unfermented cheese and spontaneously fermented products in unlicensed outlets. In this study, we have determined microbiological quality of informally retailed fresh milk products and characterized the genomic diversity and antimicrobial resistance (AMR) patterns of non-typhoidal Salmonella (NTS) in implicated products...
April 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29659885/results-from-the-survey-of-antibiotic-resistance-soar-2014-16-in-ukraine-and-the-slovak-republic
#17
D Torumkuney, T Pertseva, E Bratus, A Dziublik, V Yachnyk, A Liskova, O Sopko, K Malynovska, I Morrissey
Objectives: To determine antibiotic susceptibility in isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2014-16 from Ukraine and the Slovak Republic. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: S. pneumoniae isolates collected in Ukraine (n = 100) showed susceptibility rates ≥97% for amoxicillin, amoxicillin/clavulanic acid, penicillin [intravenous (iv) non-meningitis] and fluoroquinolones, between 83% and 86% for oral penicillin, macrolides and cefaclor, and 75% for trimethoprim/sulfamethoxazole...
April 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29659884/results-from-the-survey-of-antibiotic-resistance-soar-2014-16-in-greece
#18
D Torumkuney, J Papaparaskevas, I Morrissey
Objectives: To determine antimicrobial susceptibility in isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2014-16 from patients with community-acquired respiratory tract infections in Greece. Methods: MICs were determined by CLSI broth microdilution and susceptibility assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: A total of 99 S. pneumoniae and 52 H. influenzae isolates were collected...
April 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29659883/results-from-the-survey-of-antibiotic-resistance-soar-2014-16-in-the-czech-republic
#19
D Torumkuney, H Zemlickova, M Maruscak, I Morrissey
Objectives: To determine the antibiotic susceptibility of isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2014-16 from patients with community-acquired respiratory infections in the Czech Republic. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: S. pneumoniae isolates (n = 200) showed high rates of susceptibility (>95%) to amoxicillin, amoxicillin/clavulanic acid, penicillin [intravenous (iv) non-meningitis], ceftriaxone, cefuroxime and the fluoroquinolones using CLSI breakpoints...
April 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29659882/results-from-the-survey-of-antibiotic-resistance-soar-2014-16-in-bulgaria-romania-serbia-and-croatia
#20
D Torumkuney, M Nica, I Nistor, R Vatcheva-Dobrevska, V Petrovic, A Stoica, B Hanicar, Dj Antic, I Morrissey
Objectives: To determine antibiotic susceptibility of isolates of Streptococcus pneumoniae (n = 573) and Haemophilus influenzae (n = 345) collected in 2014-16 from Bulgaria, Romania, Serbia and Croatia. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: Among S. pneumoniae, susceptibility was generally lowest in Romania and Serbia and highest in Bulgaria...
April 1, 2018: Journal of Antimicrobial Chemotherapy
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