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https://www.readbyqxmd.com/read/28647397/actinomyces-radicidentis-and-actinomyces-haliotis-coccoid-actinomyces-species-isolated-from-the-human-oral-cavity
#1
Rolf Claesson, Ulf Sjögren, Anders Esberg, Malin Brundin, Margareta Granlund
There are few reports on the bacterial species Actinomyces radicidentis in the literature. In this study, putative A. radicidentis isolates were collected from 16 root canal samples from 601 examined patients. The isolates were examined by biochemical tests, 16S rRNA gene sequencing, Arbitrarily-primed (AP-) PCR, antibiotic susceptibility testing, and MALDI-TOF analyses. In parallel, two A. radicidentis reference strains and two putative A. radicidentis isolates from United Kingdom were tested. Sixteen of the 18 isolates were confirmed as A...
June 21, 2017: Anaerobe
https://www.readbyqxmd.com/read/28631985/effect-of-a-standardized-protocol-of-antibiotic-therapy-on-surgical-site-infection-after-laparoscopic-surgery-for-complicated-appendicitis
#2
Hyoung-Chul Park, Min Jeong Kim, Bong Hwa Lee
BACKGROUND: Although it is accepted that complicated appendicitis requires antibiotic therapy to prevent post-operative surgical infections, consensus protocols on the duration and regimens of treatment are not well established. This study aimed to compare the outcome of post-operative infectious complications in patients receiving old non-standardized and new standard antibiotic protocols, involving either 5 or 10 days of treatment, respectively. METHODS: We enrolled 1,343 patients who underwent laparoscopic surgery for complicated appendicitis between January 2009 and December 2014...
June 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28629795/epidemiological-features-and-antibiotic-resistance-patterns-of-haemophilus-influenzae-originating-from-respiratory-tract-and-vaginal-specimens-in-pediatric-patients
#3
Jian-Ping Li, Chun-Zhen Hua, Li-Ying Sun, Hong-Jiao Wang, Zhi-Min Chen, Shi-Qiang Shang
BACKGROUND: Haemophilus influenzae (H. influenzae) is a common pathogen of respiratory tract infections in children, however, as a possible cause of vulvovaginitis in prepubertal girls, its epidemiological features,antibiotic-resistance patterns, and treatment are seldom noted. METHODS: Specimens obtained from patients were inoculated on Haemophilus selective medium; and drug-sensitivities tests were determined with disc diffusion method. Cefinase disc was used to detect β-lactamase...
June 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28618388/simultaneous-determination-of-nine-%C3%AE-lactam-antibiotics-in-human-plasma-by-an-ultrafast-hydrophilic-interaction-chromatography-tandem-mass-spectrometry
#4
Alan Abdulla, Soma Bahmany, Rixt A Wijma, Bart C H van der Nagel, Birgit C P Koch
Contemporary β-lactam antibiotic dosing is debatable in severely ill patients, since the occurrence of pathophysiological changes in critical illness can result in great inter-individual variability. Therapeutic drug monitoring (TDM) is a commonly used dosing strategy to optimize exposure and thereby minimize toxicity and maximize the efficacy. Currently, TDM of β-lactam antibiotics is rarely performed, due to poor availability in clinical practice. We describe an ultrafast Hydrophilic-Interaction Chromatography (HILIC) based UPLC-MS/MS method for the determination of amoxicillin, benzylpenicillin, cefotaxime, cefuroxime, ceftazidime, flucloxacillin, imipenem, meropenem and piperacillin in human plasma...
June 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28600499/clinical-on-site-monitoring-of-%C3%A3-lactam-antibiotics-for-a-personalized-antibiotherapy
#5
R Bruch, C Chatelle, A Kling, B Rebmann, S Wirth, S Schumann, W Weber, C Dincer, G Urban
An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients' outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588285/isolation-and-characterization-of-listeria-species-from-rodents-in-natural-environments-in-china
#6
Yan Wang, Liang Lu, Ruiting Lan, Joelle K Salazar, Jingli Liu, Jianguo Xu, Changyun Ye
Listeria is ubiquitous in a variety of environments and can be isolated from a wide range of animal hosts. Rodents are capable of carrying pathogenic bacteria in their intestines, such as Listeria, and can disseminate those pathogens into the natural environment and to where human activity occurs. In this study, we investigated the occurrence and antimicrobial susceptibility of Listeria spp. isolated from wild rodents found in natural environments in China. We collected 341 intestinal fecal samples of rodents from five different regions of China, all representing different rodent habitats...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28582518/substitutions-in-pbp3-confer-resistance-to-both-ampicillin-and-extended-spectrum-cephalosporins-in-haemophilus-parainfluenzae-as-revealed-by-site-directed-mutagenesis-and-gene-recombinants
#7
Nanna H Wienholtz, Aynur Barut, Niels Nørskov-Lauritsen
Objectives: To determine the association of amino acid substitutions in PBP3 with β-lactam susceptibility in Haemophilus parainfluenzae . Methods: Single and multiple amino acid mutations at positions 385, 511 and 526 were introduced into PBP3 of a β-lactam-susceptible H. parainfluenzae strain using site-directed mutagenesis. Recombinants were also generated using PCR-amplified ftsI from clinical strains encoding multiple amino acid substitutions. MICs of ampicillin, cefuroxime, cefotaxime and ceftriaxone were determined using Etest ® ...
June 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28580612/utility-of-basophil-activation-testing-to-assess-perioperative-anaphylactic-reactions-in-real-world-practice
#8
Bernadette Eberlein, Sibylle Wigand, Heidrun Lewald, Eberhard Kochs, Johannes Ring, Tilo Biedermann, Ulf Darsow
INTRODUCTION: Perioperative anaphylactic reactions due to drugs and substances associated with general anesthesia can potentially be life-threatening. The objective of this study was to investigate the significance of the basophil activation test (BAT) for allergy diagnosis work up. METHODS: A total of 14 patients (5 men, 9 women; mean age: 57.8 years) with clinical records of anaphylactic reactions under general anesthesia were studied by means of anesthesia records, skin and serological tests...
June 5, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28577519/drug-allergy-evaluation-for-betalactam-hypersensitivity-cross-reactivity-with-cephalosporines-carbapenems-and-negative-predictive-value
#9
Mona Al-Ahmad, Tito Rodriguez-Bouza
BACKGROUND: There are no studies on cross-reactivity of betalactams among patients allergic to penicillin, or on the negative predictive value (NPV) of penicillin allergy evaluation from Arabian Gulf countries OBJECTIVE: We aimed to assess the role and NPV of drug provocation test (DPT) for betalactam hypersensitivity reactions in patients referred for allergy evaluation in Kuwait METHODS: Skin test (ST) was performed for all patients with a history of betalactam hypersensitivity, other than anaphylaxis...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28576315/electrochemical-determination-of-cephalosporins-using-a-bare-boron-doped-diamond-electrode
#10
Bogdan Feier, Ana Gui, Cecilia Cristea, Robert Săndulescu
The electrochemical oxidation of seven cephalosporins (ceftriaxone, cefotaxime, ceftazidime, cefadroxil, cefuroxime, cefaclor, cefalexin) was evaluated at high potential, using a bare boron-doped diamond electrode and the influence on the analytical response of the side chains was investigated. Based on the anodic oxidation of the cephalosporin nucleus, a simple and sensitive method was developed for the electrochemical detection of cefalexin by differential pulse voltammetry. After the optimization of the experimental conditions, a linear correlation was obtained between the peak height and the molar concentration of cefalexin in the range of 0...
July 11, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28574956/identifying-high-alert-medications-in-a-university-hospital-by-applying-data-from-the-medication-error-reporting-system
#11
Lotta Tyynismaa, Anni Honkala, Marja Airaksinen, Kenneth Shermock, Lasse Lehtonen
OBJECTIVES: To facilitate safe use of high-alert medications, lists of medications posing higher risks for medication errors (MEs) and harmful effects have been compiled. These lists can be general or reflect clinical practices in specific settings. Less common has been to compile a hospital-specific list applying data from the organization's ME reporting system. Our objective was to demonstrate a method for compiling such a high-alert medication list in a university hospital. METHODS: Of the eighteen 136 MEs reported during 2007 to 2013, ME reports with medications coded as a contributing factor to the incident were included (n = 249)...
June 1, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28561169/-adequate-antibiotic-prophylaxis-and-therapy-of-periprosthetic-infections-of-the-breast-review-of-468-consecutive-implant-removals
#12
Jörn Andreas Lohmeyer, Mai Alawadi, Philipp Alexander Bergmann, Daniel Schmauss, Klaus Stephan Wittig
Background Periprosthetic infections are feared complications in aesthetic as well as in reconstructive breast surgery. The purpose of our study was to evaluate our institution's specific culture data and to identify most common organisms and suitable antibiotics for prophylaxis and first line treatment in implant-based breast surgery. Patients and Methods We analyzed all patients with a change or removal of breast implants in the period from 01.01.2012 to 31.12.2015 retrospectively. Based on the medical records, the surgical indications were identified and specifically analyzed for signs of infection and capsular fibrosis...
April 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28556943/infected-mediastinal-bronchogenic-cyst-successfully-treated-by-eus-fna-drainage-via-esophagus
#13
I O Davarashvili, Yulia Epstein, Tawfik Khoury
A 61-year old female admitted with complaints of 10 days of productive cough and fever of 38 °C. She was started on antibiotics with oral cefuroxime 500 mg and azithromycin 500 mg. An X-Ray showed mediastinal mass with an air-fluid within. The patient was referred to our institution due to a suspicion of lung abscess. This article is protected by copyright. All rights reserved.
May 29, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28546689/risks-of-cefuroxime-prophylaxis-for-postcataract-endophthalmitis
#14
REVIEW
Khaled A Al-Abduljabbar, Donald U Stone
BACKGROUND: Endophthalmitis after cataract surgery is a rare but vision-threatening complication. Intracameral cefuroxime (ICC) has been reported to be effective at reducing the risk, but concerns regarding the risks associated with this intervention remain. METHODS: Systematic review and synthesis of the literature on ICC, with a focus on the risks of therapy. RESULTS: Level 2a evidence was found to support the use of cefuroxime in penicillin-allergic patients...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28543859/pustular-erythema-multiforme-major-associated-with-atypical-pneumonia
#15
R Wolf, S Ständer, O Well, L Frey, I Klier, S Brunner, M Flaig, A Wollenberg, T Ruzicka
A 52-year-old male patient presented to the hospital with severe difficulties swallowing, sore eyes and an asymptomatic skin rash. The patient was fully oriented, vital signs were normal. Two days before admission to the hospital, the referring physician had suspected an upper respiratory tract infection and had started treatment with oral cefuroxime while also prescribing ibuprofen for sore throat. This article is protected by copyright. All rights reserved.
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28529866/which-orthopaedic-patients-are-infected-with-gram-negative-non-fermenting-rods
#16
Omid Jamei, Shpresa Gjoni, Besa Zenelaj, Benjamin Kressmann, Wilson Belaieff, Didier Hannouche, Ilker Uçkay
Background : 1(st) and 2(nd) generation cephalosporins used for perioperative prophylaxis in orthopaedic surgery do not cover non-fermenting Gram-negative rods (NFR). Methods: Epidemiological cohort study of adult patients operated for orthopedic infections between 2004 and 2014 with perioperative cefuroxim or vancomycin prophylaxis. Exclusion of polyneuropathic ischemic foot infections and septic bursitis cases. Results: Of the total 1840 surgical procedures in the study, 430 grew Gram-negative pathogens (23%), of which 194 (11%) were due to NFR and 143 (8%) to Pseudomonas aeruginosa...
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28526202/capnocytophaga-canimorsus-an-underestimated-cause-of-periprosthetic-joint-infection
#17
Marcel Orth, Patrick Orth, Konstantinos Anagnostakos
BACKGROUND: Periprosthetic joint infection (PJI) is a major clinical problem in orthopedic surgery. Capnocytophaga canimorsus (C. canimorsus) is an unusual and hardly detectable bacterium. A review of the literature indicates that C. canimorsus affects mainly immunocompromised patients. It has not been reported to cause periprosthetic joint infections in immunocompetent patients so far. This case report aims to raise awareness of C. canimorsus in orthopedic surgery with special regard to joint arthroplasty...
May 16, 2017: Knee
https://www.readbyqxmd.com/read/28503446/comment-on-hydration-with-cefuroxime-a-method-for-sealing-a-small-leaking-corneal-perforation
#18
Murat Aslankurt, Osman Çekiç
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499779/-treating-through-decision-and-follow-up-in-antibiotic-therapy-associated-exanthemas
#19
Axel Trautmann, Sandrine Benoit, Matthias Goebeler, Johanna Stoevesandt
BACKGROUND: Immediate discontinuation or replacement of suspected drugs is considered standard medical care in acute exanthematous skin reactions. In the treatment of bacterial infections, structurally different alternative antibiotics, however, are commonly second choice options due to a suboptimal antimicrobial activity or an unfavorable side effect profile. Nonetheless, "treating through," the continuation of antibiotic treatment despite an objective exanthema, is practiced only rarely...
May 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28497052/etiological-and-resistance-profile-of-bacteria-involved-in-urinary-tract-infections-in-young-children
#20
Antonio Sorlózano-Puerto, José María Gómez-Luque, Juan de Dios Luna-Del-Castillo, José María Navarro-Marí, José Gutiérrez-Fernández
Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated...
2017: BioMed Research International
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