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MAOA gene

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https://www.readbyqxmd.com/read/29781947/childhood-trauma-dna-methylation-of-stress-related-genes-and-depression-findings-from-two-monozygotic-twin-studies
#1
Hao Peng, Yun Zhu, Eric Strachan, Emily Fowler, Tamara Bacus, Peter Roy-Byrne, Jack Goldberg, Viola Vaccarino, Jinying Zhao
OBJECTIVE: DNA methylation has been associated with both early life stress and depression. This study examined the combined association of DNA methylation at multiple CpG probes in five stress-related genes with depressive symptoms, and tested whether these genes methylation mediated the association between childhood trauma and depression in two monozygotic (MZ) twin studies. METHODS: The current analysis comprised 119 MZ twin pairs (84 male pairs [mean 55 years], and 35 female pairs [mean 36 years])...
May 17, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29730831/the-relationship-between-the-maoa-uvntr-polymorphism-delinquent-peer-affiliation-and-antisocial-behavior-with-a-consideration-of-sex-differences
#2
Eric M Cooke, Todd Armstrong, Danielle Boisvert, Jessica Wells, Richard H Lewis, Sheree Hughes-Stamm, David Gangitano
With the advent of new and more readily usable gene sequencing techniques, researchers have been able to examine the interactions between genes and the environment (G X E) within a multitude of scientific perspectives. One area that G X E interactions have been implicated in is the development of antisocial behavior (ASB). Antisocial behavior consists of a wide range of maladaptive behaviors and has been at the forefront of public health and mental health concerns for decades. One genetic polymorphism that has been associated with ASB is MAOA-uVNTR...
May 5, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29712944/appetitive-and-reactive-aggression-are-differentially-associated-with-the-stin2-genetic-variant-in-the-serotonin-transporter-gene
#3
Sian Megan Joanna Hemmings, Khethelo Xulu, Jessica Sommer, Martina Hinsberger, Stefanie Malan-Muller, Gerard Tromp, Thomas Elbert, Roland Weierstall, Soraya Seedat
Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667298/distinct-chromatin-structures-at-the-monoamine-oxidase-a-maoa-promoter-correlate-with-allele-specific-expression-in-sh-sy5y-cells
#4
M Manca, V Pessoa, P Myers, A Pickles, J Hill, H Sharp, C Murgatroyd, V J Bubb, J P Quinn
Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders. A polymorphic repetitive DNA domain, termed the uVNTR (upstream variable number tandem repeat), located at the promoter of the MAOA gene is a risk factor for many of these disorders. MAOA is on the X chromosome suggesting gender could play a role in regulation. We analysed MAOA regulation in the human female cell line, SH-SY5Y, which is polymorphic for the uVNTR. This heterozygosity allowed us to correlate allele specific gene expression with allele specific transcription factor binding and epigenetic marks for MAOA...
April 18, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29617172/a-case-of-exudative-vitreoretinopathy-and-chorioretinal-coloboma-associated-with-microcephaly-in-a-female-with-contiguous-xp11-3-11-4-deletion
#5
Anne-Marie Hinds, Elisabeth Rosser, M Ashwin Reddy
The constellation of signs including microcephaly, retinal colobomas, and exudative vitreo-retinopathy suggests a mutation of the KIF-11 gene on chromosome 10q. We report a female infant with these features but due, instead, to a contiguous gene deletion on chromosome Xp including the OMIM morbid genes CASK, KDM6A, NDP, MAOA, NYX, and DDX3X. The NDP deletion could account for the exudative retinopathy and the CASK deletion for the microcephaly, while CASK and KDM6A have both been associated with coloboma. This case highlights genetic heterogeneity for the clustering of these signs...
April 4, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29602729/sperm-count-and-motility-are-quantitatively-affected-by-functional-polymorphisms-of-htr2a-maoa-and-slc18a
#6
Miriam Cortés-Rodriguez, Jose-Luis Royo, Arturo Reyes-Palomares, Ana M Lendínez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel
Spermatozoa and neurones share similar membrane characteristics and features. Associations of multiple polymorphisms traditionally related to neurotransmission were investigated. Infertile men were grouped into controls with normospermia (n = 182) and idiopathic infertile men with asthenozoospermia (n = 103), and analysed as a case-control study and as a quantitative association of each genotype. Ten neurotransmission-associated genetic variants were mapped by SNP analysis using quantitative polymerase chain reaction with TaqMan probes...
February 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29600412/associations-of-monoamine-oxidase-a-gene-first-exon-methylation-with-sexual-abuse-and-current-depression-in-women
#7
David Checknita, Tomas J Ekström, Erika Comasco, Kent W Nilsson, Jari Tiihonen, Sheilagh Hodgins
Childhood physical abuse (PA) and sexual abuse (SA) interact with monoamine oxidase A (MAOA) gene polymorphism to modify risk for mental disorders. In addition, PA and SA may alter gene activity through epigenetic mechanisms such as DNA methylation, thereby further modifying risk for disorders. We investigated whether methylation in a region spanning the MAOA first exon and part of the first intron was associated with PA and/or SA, MAOA genotype, alcohol dependence, drug dependence, depression disorders, anxiety disorders, and conduct disorder...
March 29, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29575277/association-study-of-functional-polymorphisms-of-dopaminergic-pathway-in-epilepsy-related-factors-of-temporal-lobe-epilepsy-in-brazilian-population
#8
Juliana A Alcantara, Silvia Vincentiisa, Daniel S Kerr, Bernardo Dos Santos, Ruda Alessi, Helio van der Linden, Tiffany Chaim, Maurício H Serpa, Geraldo Busatto, Wagner F Gattaz, Renata Demarque, Kette Dr Valente
BACKGROUND: There is scarce data about the role of neurotransmission modulated by dopamine (DA) in epilepsy, especially temporal lobe epilepsy. This is the first study that aimed to analyze the dopaminergic polymorphisms in an etiologically homogeneous group of patients with temporal lobe epilepsy determined by hippocampal sclerosis (TLE-HS). Selected polymorphisms were: (i) the most expressed receptors in the limbic system D2-like (DRD2/ANKK1 TAQ-1A, D4_VNTR, and D4_rs1800955); (ii) the dopamine transporter DAT - 3 'untranslated region (3'UTR) and Intron 8; (iii) two degrading enzymes regulating the synaptic activity - the main metabolizer of dopamine Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA)...
March 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29557505/differences-in-snp-genotype-distributions-between-complex-and-simple-suicides
#9
Tanja Čugura, Jakob Boh, Tomaž Zupanc, Peter Pregelj, Alja Videtič Paska
Dysregulations in serotonin neurotransmission can be a strong contributing factor in suicide and impulsive-aggressive personality traits. Victims of suicide form a heterogeneous group in terms of planning, lethality and number of used methods. In this study, we tested single nucleotide polymorphisms (SNPs) of the monoamine oxidase (MAO) A and B genes on the Slovenian population, which has one of the highest suicide rates in the world. Genotyping was performed on 77 victims of complex suicide, 406 victims of simple suicide and 289 controls...
March 20, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29542091/the-regulation-of-monoamine-oxidase-a-gene-expression-by-distinct-variable-number-tandem-repeats
#10
Maurizio Manca, Veridiana Pessoa, Ana Illera Lopez, Patrick T Harrison, Fabio Miyajima, Helen Sharp, Andrew Pickles, Jonathan Hill, Chris Murgatroyd, Vivien J Bubb, John P Quinn
The monoamine oxidase A (MAOA) uVNTR (upstream variable number tandem repeat) is one of the most often cited examples of a gene by environment interaction (GxE) in relation to behavioral traits. However, MAOA possesses a second VNTR, 500 bp upstream of the uVNTR, which is termed d- or distal VNTR. Furthermore, genomic analysis indicates that there are a minimum of two transcriptional start sites (TSSs) for MAOA, one of which encompasses the uVNTR within the 5' untranslated region of one of the isoforms. Through expression analysis in semi-haploid HAP1 cell lines genetically engineered in order to knockout (KO) either the uVNTR, dVNTR, or both VNTRs, we assessed the effect of the two MAOA VNTRs, either alone or in combination, on gene expression directed from the different TSSs...
March 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29505805/analysis-of-promoter-polymorphism-in-monoamine-oxidase-a-maoa-gene-in-completed-suicide-on-slovenian-population
#11
Katarina Uršič, Tomaž Zupanc, Alja Videtič Paska
Suicide is a well-defined public health problem and is a complex phenomenon influenced by a number of different risk factors, including genetic ones. Numerous studies have examined serotonin system genes. Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Upstream variable number of tandem repeats (uVNTR) in the promoter region of MAOA gene affects the activity of transcription. In the present study we genotyped MAOA-uVNTR polymorphism in 266 suicide victims and 191 control subjects of Slovenian population, which ranks among the European and world populations with the highest suicide rate...
April 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29478144/integration-of-transcriptomic-and-cytoarchitectonic-data-implicates-a-role-for-maoa-and-tac1-in-the-limbic-cortical-network
#12
Sebastian Bludau, Thomas W Mühleisen, Simon B Eickhoff, Michael J Hawrylycz, Sven Cichon, Katrin Amunts
Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while the JuBrain Atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. To date, an integrated framework that combines the analytical benefits of both scientific platforms towards a multi-level brain atlas of adult humans was not available...
February 24, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29467046/the-interaction-between-monoamine-oxidase-a-maoa-and-childhood-maltreatment-as-a-predictor-of-personality-pathology-in-females-emotional-reactivity-as-a-potential-mediating-mechanism
#13
Amy L Byrd, Stephen B Manuck, Samuel W Hawes, Tayler J Vebares, Vishwajit Nimgaonkar, Kodavali V Chowdari, Alison E Hipwell, Kate Keenan, Stephanie D Stepp
Research consistently demonstrates that common polymorphic variation in monoamine oxidase A (MAOA) moderates the influence of childhood maltreatment on later antisocial behavior, with growing evidence that the "risk" allele (high vs. low activity) differs for females. However, little is known about how this Gene × Environment interaction functions to increase risk, or if this risk pathway is specific to antisocial behavior. Using a prospectively assessed, longitudinal sample of females (n = 2,004), we examined whether changes in emotional reactivity (ER) during adolescence mediated associations between this Gene × Environment and antisocial personality disorder in early adulthood...
February 22, 2018: Development and Psychopathology
https://www.readbyqxmd.com/read/29439093/dysregulated-genes-and-their-functional-pathways-in-luteinized-granulosa-cells-from-pcos-patients-after-cabergoline-treatment
#14
H Ferrero, P Díaz-Gimeno, P Sebastián-León, A Faus, R Gómez, A Pellicer
Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Therefore, to understand the PCOS ovarian physiology, it is important to explore the mechanisms that underlie syndrome based on the therapeutic effects of Cb2...
April 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29434543/altered-functional-connectivity-of-fronto-cingulo-striatal-circuits-during-error-monitoring-in-adolescents-with-a-history-of-childhood-abuse
#15
Heledd Hart, Lena Lim, Mitul A Mehta, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with error hypersensitivity. We examined the effect of childhood abuse and abuse-by-gene ( 5-HTTLPR, MAOA ) interaction on functional brain connectivity during error processing in medication/drug-free adolescents. Functional connectivity was compared, using generalized psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 22 age- and gender-matched medication-naïve and substance abuse-free adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed an individually adjusted tracking stop-signal task, designed to elicit 50% inhibition failures...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29423924/timing-of-prenatal-exposure-to-trauma-and-altered-placental-expressions-of-hypothalamic-pituitary-adrenal-axis-genes-and-genes-driving-neurodevelopment
#16
W Zhang, Q Li, M Deyssenroth, L Lambertini, J Finik, J Ham, Y Huang, K J Tsuchiya, P Pehme, J Buthmann, S Yoshida, J Chen, Y Nomura
Prenatal maternal stress increases the risk for negative developmental outcomes in offspring; however, the underlying biological mechanisms remain largely unexplored. In the present study, alterations in placental gene expression associated with maternal stress were examined to clarify the potential underlying epi/genetic mechanisms. Expression levels of 40 selected genes involved in regulating foetal hypothalamic-pituitary-adrenal axis and neurodevelopment were profiled in placental tissues collected from a birth cohort established around the time of Superstorm Sandy...
April 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29423105/transcriptome-profiling-identified-differentially-expressed-genes-and-pathways-associated-with-tamoxifen-resistance-in-human-breast-cancer
#17
Xin Men, Jun Ma, Tong Wu, Junyi Pu, Shaojia Wen, Jianfeng Shen, Xun Wang, Yamin Wang, Chao Chen, Penggao Dai
Tamoxifen (TAM) resistance is an important clinical problem in the treatment of breast cancer. In order to identify the mechanism of TAM resistance for estrogen receptor (ER)-positive breast cancer, we screened the transcriptome using RNA-seq and compared the gene expression profiles between the MCF-7 mamma carcinoma cell line and the TAM-resistant cell line TAMR/MCF-7, 52 significant differential expression genes (DEGs) were identified including SLIT2, ROBO, LHX, KLF , VEGFC, BAMBI, LAMA1, FLT4, PNMT, DHRS2, MAOA and ALDH...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415053/the-association-between-glutamine-repeats-in-the-androgen-receptor-gene-and-personality-traits-in-dromedary-camel-camelus-dromedarius
#18
Sherif Ramadan, Amira M Nowier, Yusuke Hori, Miho Inoue-Murayama
Temperament traits such as fearfulness are important as they define an animal's responses to its environment and handling. The increasing automation of daily tasks and growing population limits contact between camels and humans. Such limitations contribute to fear of humans and changes in physical environment. Monoamine oxidase A (MAOA) and androgen receptor (AR) genes are important candidates associated with mammal personality. In our analysis, MAOA exon 15 showed no polymorphism but a novel polymorphism was seen in the camel AR exon 1; 16, 17, 18, and 19 glutamine repeats were detected...
2018: PloS One
https://www.readbyqxmd.com/read/29321361/a-novel-contiguous-deletion-involving-ndp-maob-and-efhc2-gene-in-a-patient-with-familial-norrie-disease-bilateral-blindness-and-leucocoria-without-other-deficits
#19
Bei Jia, Liping Huang, Yaoyu Chen, Siping Liu, Cuihua Chen, Ke Xiong, Lanlin Song, Yulai Zhou, Xinping Yang, Mei Zhong
Contiguous microdeletions of the Norrie disease pseudoglioma (NDP) region on chromosome Xp11.3 have been widely confirmed as contributing to the typical clinical features of Norrie disease (ND). However, the precise relation between genotype and phenotype could vary. The contiguous deletion of NDP and its neighbouring genes, MAOA/B and EFHC2, reportedly leads to syndromic clinical features such as microcephaly, intellectual disability, and epilepsy. Herewe report a novel contiguous microdeletion of the NDP region containing the MAOB and EFHC2 genes,which causes eye defects but no cognitive disability...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29190830/reduced-functional-connectivity-of-fronto-parietal-sustained-attention-networks-in-severe-childhood-abuse
#20
Heledd Hart, Lena Lim, Mitul A Mehta, Antonia Chatzieffraimidou, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with attention deficits. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA, FKBP5) interaction on functional brain connectivity during sustained attention in medication/drug-free adolescents. Functional connectivity was compared, using generalised psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 21 age-and gender-matched adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed a parametrically modulated vigilance task requiring target detection with a progressively increasing load of sustained attention...
2017: PloS One
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