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MAOA gene

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https://www.readbyqxmd.com/read/28101368/polymorphisms-in-the-canine-monoamine-oxidase-a-maoa-gene-identification-and-variation-among-five-broad-dog-breed-groups
#1
James Sacco, Andrew Ruplin, Paul Skonieczny, Michael Ohman
BACKGROUND: In humans, reduced activity of the enzyme monoamine oxidase type A (MAOA) due to genetic polymorphisms within the MAOA gene leads to increased brain neurotransmitter levels associated with aggression. In order to study MAOA genetic diversity in dogs, we designed a preliminary study whose objectives were to identify novel alleles in functionally important regions of the canine MAOA gene, and to investigate whether the frequencies of these polymorphisms varied between five broad breed groups (ancient, herding, mastiff, modern European, and mountain)...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28097908/common-and-specific-genes-and-peripheral-biomarkers-in-children-and-adults-with-attention-deficit-hyperactivity-disorder
#2
Cristian Bonvicini, Stephen V Faraone, Catia Scassellati
OBJECTIVES: Elucidating the biological mechanisms involved in Attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age. METHODS: We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults. A systematic search (up until February, 2016) was conducted. RESULTS: From a PRISMA flow-chart, a total of eligibility 350 studies from genomics and metabolomics were found for cADHD and 91 for aADHD...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28094812/putative-presynaptic-dopamine-dysregulation-in-schizophrenia-is-supported-by-molecular-evidence-from-post-mortem-human-midbrain
#3
T D Purves-Tyson, S J Owens, D A Rothmond, G M Halliday, K L Double, J Stevens, T McCrossin, C Shannon Weickert
The dopamine hypothesis of schizophrenia posits that increased subcortical dopamine underpins psychosis. In vivo imaging studies indicate an increased presynaptic dopamine synthesis capacity in striatal terminals and cell bodies in the midbrain in schizophrenia; however, measures of the dopamine-synthesising enzyme, tyrosine hydroxylase (TH), have not identified consistent changes. We hypothesise that dopamine dysregulation in schizophrenia could result from changes in expression of dopamine synthesis enzymes, receptors, transporters or catabolic enzymes...
January 17, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28088578/the-effect-of-long-term-hindlimb-unloading-on-the-expression-of-risk-neurogenes-encoding-elements-of-serotonin-dopaminergic-systems-and-apoptosis-comparison-with-the-effect-of-actual-spaceflight-on-mouse-brain
#4
E A Kulikova, V A Kulikov, N A Sinyakova, A V Kulikov, N K Popova
The study of spaceflight effects on the brain is technically complex concern; complicated by the problem of applying an adequate ground model. The most-widely used experimental model to study the effect of microgravity is the tail-suspension hindlimb unloading model; however, its compliance with the effect of actual spaceflight on the brain is still unclear. We evaluated the effect of one month hindlimb unloading on the expression of genes related to the brain neuroplasticity - brain neutotrophic factors (Gdnf, Cdnf), apoptotic factors (Bcl-xl, Bax), serotonin- and dopaminergic systems (5-HT2A, Maoa, Maob, Th, D1r, Comt), and compared the results with the data obtained on mice that spent one month in spaceflight on Russian biosatellite Bion-M1...
January 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27989490/paraphilic-sexual-offenders-do-not-differ-from-control-subjects-with-respect-to-dopamine-and-serotonin-related-genetic-polymorphisms
#5
Andrzej Jakubczyk, Aleksandra Krasowska, Marcin Bugaj, Maciej Kopera, Anna Klimkiewicz, Agata Łoczewska, Aneta Michalska, Aleksandra Majewska, Natalia Szejko, Anna Podgórska, Małgorzata Sołowiej, Leszek Markuszewski, Sławomir Jakima, Rafał Płoski, Kirk Brower, Marcin Wojnar
INTRODUCTION: Rape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors. AIM: To analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects. METHODS: The study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76)...
December 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27935229/cortico-limbic-connectivity-in-maoa-l-carriers-is-vulnerable-to-acute-tryptophan-depletion
#6
Patrick Eisner, Martin Klasen, Dhana Wolf, Klaus Zerres, Thomas Eggermann, Albrecht Eisert, Mikhail Zvyagintsev, Pegah Sarkheil, Krystyna A Mathiak, Florian Zepf, Klaus Mathiak
INTRODUCTION: A gene-environment interaction between expression genotypes of the monoamine oxidase A (MAOA) and adverse childhood experience increases the risk of antisocial behavior. However, the neural underpinnings of this interaction remain uninvestigated. A cortico-limbic circuit involving the prefrontal cortex (PFC) and the amygdala is central to the suppression of aggressive impulses and is modulated by serotonin (5-HT). MAOA genotypes may modulate the vulnerability of this circuit and increase the risk for emotion regulation deficits after specific life events...
December 9, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27880961/characterization-of-aspergillus-sojae-isolated-from-meju-korean-traditional-fermented-soybean-bricks
#7
Kyung Min Kim, Jaeho Lim, Jae Jung Lee, Byung-Serk Hurh, Inhyung Lee
Initially, we screened 18 A. sojae-like strains from Aspergillus spp. isolated from meju (Korean traditional fermented soybean bricks) according to their morphological characteristics. Because members of Aspergillus section Flavi are often incorrectly identified because of their phylogenetic similarity, we re-identified these strains at morphological and molecular genetic levels. Fourteen strains were finally identified as A. sojae. The isolates produced protease and α-amylase with ranges of 2.66-10.64 and 21...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27852517/regulation-of-emotional-response-in-juvenile-monkeys-treated-with-fluoxetine-maoa-interactions
#8
M S Golub, C E Hogrefe, A M Bulleri
Juvenile male rhesus macaques received therapeutic doses of fluoxetine daily from one to three years of age and were compared to vehicle-treated controls (N=16/group). Genotyping for monoamine oxidase A (MAOA) polymorphisms was used to form subgroups (N=8) with high and low expression of the gene. Behavioral responses were scored during 30-second exposures to pictures differing in affective content. As expected from its therapeutic effect, fluoxetine decreased the behavioral response to emotionally evocative pictures...
December 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27821364/modification-of-the-association-between-early-adversity-and-obsessive-compulsive-disorder-by-polymorphisms-in-the-maoa-maob-and-comt-genes
#9
N W McGregor, S M J Hemmings, L Erdman, I Calmarza-Font, D J Stein, C Lochner
The monoamine oxidases (MAOA/B) and catechol-O-methyltransferase (COMT) enzymes break down regulatory components within serotonin and dopamine pathways, and polymorphisms within these genes are candidates for OCD susceptibility. Childhood trauma has been linked OCD psychopathology, but little attention has been paid to the interactions between genes and environment in OCD aetiology. This pilot study investigated gene-by-environment interactions between childhood trauma and polymorphisms in the MAOA, MAOB and COMT genes in OCD...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27629597/genetic-moderation-of-intervention-efficacy-dopaminergic-genes-the%C3%A2-incredible-years-and-externalizing-behavior-in-children
#10
Rabia R Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio de Castro, Danielle van der Giessen, Jay Belsky
This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents' manifested the most positive change in parenting in response to the intervention...
September 15, 2016: Child Development
https://www.readbyqxmd.com/read/27613936/high-prevalence-of-smoking-in-the-roma-population-seems-to-have-no-genetic-background
#11
Szilvia Fiatal, Réka Tóth, Ágota Moravcsik-Kornyicki, Zsigmond Kósa, János Sándor, Martin McKee, Róza Ádány
INTRODUCTION: The prevalence of smoking in Romani of both genders is significantly higher than in the general population. Our aim was to determine whether a genetic susceptibility contributes to the high prevalence of smoking among Roma in a study based on data collected from cross-sectional surveys. METHODS: Twenty single nucleotide polymorphisms known to be closely related to smoking behavior were investigated in DNA samples of Hungarian Roma (N = 1273) and general (N = 2388) populations...
December 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27610078/maoa-influences-the-trajectory-of-attentional-development
#12
Rebecca A Lundwall, Claudia G Rasmussen
Attention is vital to success in all aspects of life (Meck and Benson, 2002; Erickson et al., 2015), hence it is important to identify biomarkers of later attentional problems early enough to intervene. Our objective was to determine if any of 11 genes (APOE, BDNF, HTR4, CHRNA4, COMT, DRD4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25) predicted the trajectory of attentional development within the same group of children between infancy and childhood. We recruited follow up participants from children who participated as infants in visual attention studies and used a similar task at both time points...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27545756/gene-x-environment-interactions-in-conduct-disorder-implications-for-future-treatments
#13
Nathalie E Holz, Katrin Zohsel, Manfred Laucht, Tobias Banaschewski, Sarah Hohmann, Daniel Brandeis
Conduct disorder (CD) causes high financial and social costs, not only in affected families but across society, with only moderately effective treatments so far. There is consensus that CD is likely caused by the convergence of many different factors, including genetic and adverse environmental factors. There is ample evidence of gene-environment interactions in the etiology of CD on a behavioral level regarding genetically sensitive designs and candidate gene-driven approaches, most prominently and consistently represented by MAOA...
August 18, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27450565/vitamin-d-signaling-and-the-differentiation-of-developing-dopamine-systems
#14
Renata A N Pertile, Xiaoying Cui, Darryl W Eyles
Vitamin D regulates multiple factors including those involved in the ontogeny of dopaminergic systems. It has been shown that in neonatal rats maternally deprived of vitamin D, dopamine (DA) turnover is decreased with associated reductions in one catabolic enzyme, catechol-o-methyl transferase (COMT). To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27444553/a-test-replicate-approach-to-candidate-gene-research-on-addiction-and-externalizing-disorders-a-collaboration-across-five-longitudinal-studies
#15
Diana R Samek, Jennifer Bailey, Karl G Hill, Sylia Wilson, Susanne Lee, Margaret A Keyes, Marina Epstein, Andrew Smolen, Michael Miller, Ken C Winters, J David Hawkins, Richard F Catalano, William G Iacono, Matt McGue
This study presents results from a collaboration across five longitudinal studies seeking to test and replicate models of gene-environment interplay in the development of substance use and externalizing disorders (SUDs, EXT). We describe an overview of our conceptual models, plan for gene-environment interplay analyses, and present main effects results evaluating six candidate genes potentially relevant to SUDs and EXT (MAOA, 5-HTTLPR, COMT, DRD2, DAT1, and DRD4). All samples included rich longitudinal and phenotypic measurements from childhood/adolescence (ages 5-13) through early adulthood (ages 25-33); sample sizes ranged from 3487 in the test sample, to ~600-1000 in the replication samples...
September 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27381555/genetic-variants-of-maob-affect-serotonin-level-and-specific-behavioral-attributes-to-increase-autism-spectrum-disorder-asd-susceptibility-in-males
#16
Barnali Chakraborti, Deepak Verma, Arijit Karmakar, Preeti Jaiswal, Aritrika Sanyal, Debarshi Paul, Swagata Sinha, Asem Surindro Singh, Subhrangshu Guhathakurta, Anirban Roychowdhury, Chinmoy Kumar Panda, Saurabh Ghosh, Kochupurackal P Mohanakumar, Kanchan Mukhophadhyay, Usha Rajamma
Serotonergic system participates in various developmental processes and modulation of behaviour. Autism Spectrum Disorder (ASD) is characterized by a range of behavioral symptoms scaling from mild to severe. Abnormal 5-HT synthesis and signalling, platelet hyperserotonemia and amelioration of repetitive behaviours by SSRI are some of the key findings, which reinforced the hypothesis that serotonergic genes might act as ASD susceptible genes. Therefore, genes encoding monoamine oxidases A/B (MAOA/MAOB) received special attention as these genes are located on the X-chromosome and the gene products are responsible for 5-HT degradation...
November 3, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27350097/genetic-influences-on-conduct-disorder
#17
Jessica E Salvatore, Danielle M Dick
Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist...
June 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27341797/monoamine-oxidase-b-gene-variants-associated-with-attention-deficit-hyperactivity-disorder-in-the-indo-caucasoid-population-from-west-bengal
#18
Arijit Karmakar, Subhamita Maitra, Barnali Chakraborti, Deepak Verma, Swagata Sinha, Kochupurackal P Mohanakumar, Usha Rajamma, Kanchan Mukhopadhyay
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is characterized by symptoms of inattention, excessive motor activity and impulsivity detected mostly during childhood. These traits are known to be controlled by monoamine neurotransmitters, chiefly dopamine, serotonin and norepinephrine. Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups...
2016: BMC Genetics
https://www.readbyqxmd.com/read/27300740/interacting-effect-of-maoa-genotype-and-maternal-prenatal-smoking-on-aggressive-behavior-in-young-adulthood
#19
Sarah Hohmann, Katrin Zohsel, Arlette F Buchmann, Dorothea Blomeyer, Nathalie Holz, Regina Boecker-Schlier, Christine Jennen-Steinmetz, Marcella Rietschel, Stephanie H Witt, Martin H Schmidt, Günter Esser, Andreas Meyer-Lindenberg, Tobias Banaschewski, Daniel Brandeis, Erika Hohm, Manfred Laucht
Findings on the etiology of aggressive behavior have provided evidence for an effect both of genetic factors, such as variation in the monoamine oxidase A (MAOA) gene, and adverse environmental factors. Recent studies have supported the existence of gene × environment interactions, with early experiences playing a key role. In the present study, the effects of prenatal nicotine exposure, MAOA genotype and their interaction on aggressive behavior during young adulthood were examined. In a sample of 272 young adults (129 males, 143 females) from an epidemiological cohort study, smoking during pregnancy was measured with a standardized parent interview at the offspring's age of 3 months...
August 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27238716/differential-patterning-of-genes-involved-in-serotonin-metabolism-and-transport-in-extra-embryonic-tissues-of-the-mouse
#20
Hsiao-Huei Wu, Sera Choi, Pat Levitt
INTRODUCTION: Serotonin (5-HT) is an important neuromodulator, but recently has been shown to be involved in neurodevelopment. Although previous studies have demonstrated that the placenta is a major source of forebrain 5-HT during early forebrain development, the processes of how 5-HT production, metabolism, and transport from placenta to fetus are regulated are unknown. As an initial step in determining the mechanisms involved, we investigated the expression patterns of genes critical for 5-HT system function in mouse extraembryonic tissues...
June 2016: Placenta
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