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ischemic memory

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https://www.readbyqxmd.com/read/29467328/allograft-dendritic-cell-p40-homodimers-activate-donor-reactive-memory-cd8-t-cells
#1
Hidetoshi Tsuda, Charles A Su, Toshiaki Tanaka, Katayoun Ayasoufi, Booki Min, Anna Valujskikh, Robert L Fairchild
Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior to organ transplantation increase early posttransplant inflammation and negatively impact early graft function and long-term graft outcome. Little is known about the mechanisms enhancing endogenous memory T cell activation to mediate tissue injury within the increased inflammatory environment of allografts subjected to prolonged cold ischemic storage (CIS)...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29452136/neuroprotective-effects-of-valproic-acid-on-brain-ischemia-are-related-to-its-hdac-and-gsk3-inhibitions
#2
Monalisa Ribeiro Silva, Alyne Oliveira Correia, Gabriel Cabral Alencar Dos Santos, Lucas Leimig Telles Parente, Keicy Parente de Siqueira, Danielly Gonçalves Sombra Lima, Jonathan Almeida Moura, Ana Elisa da Silva Ribeiro, Roberta Oliveira Costa, Daniel Luna Lucetti, Elaine Cristina Pereira Lucetti, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders. The objective was to evaluate the neuroprotective effects of VA on a brain ischemia model. The groups of male Wistar rats were: SO (sham-operated), ischemic and ischemic treated with VA (25, 50 and 100 mg/kg, p.o.). After anesthesia with ketamine and xilazine, the animals were subjected to clamping of carotid arteries (30 min) and reperfusion. Except for the carotid clamping, the SO group was submitted to the same procedure...
February 13, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29408270/gaba-function-may-be-related-to-the-impairment-of-learning-and-memory-caused-by-systemic-prenatal-hypoxia-ischemia
#3
Marta Cristina Cunha-Rodrigues, Cassiana Thayara do Nascimento Balduci, Frank Tenório, Penha Cristina Barradas
Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant rat is obstructed for 45 minutes we have described oligodendrocyte death, astrogliosis and neuronal loss. In this work we investigated hippocampal neuronal population and performed a functional evaluation of memory and learning of young rats that had been affected by prenatal HI...
February 3, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29406402/impaired-cognitive-performance-in-endothelial-nitric-oxide-synthase-knock-out-mice-after-ischemic-stroke-a-pilot-study
#4
Shanshan Li, Yao Wang, Ze Jiang, Yaping Huai, James K Liao, Kaari A Lynch, Ross Zafonte, Lisa J Wood, Qing Mei Wang
OBJECTIVES: Cognitive dysfunction and dementia are common following ischemic stroke. Endothelial nitric oxide synthase (eNOS) has been found to play an important role in neurological function and cognition. The purpose of the present study was to assess the specific role of eNOS in cognitive performance after stroke. DESIGN: Male wildtype (WT) and mice lacking eNOS (eNOS) underwent middle cerebral artery occlusion (MCAO) or sham-surgery. Primary outcomes were repeated measures of neurological score, limb asymmetry, sensory/motor function and spatial memory/learning assessed at intervals up to 28-days post-surgery...
February 5, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29393247/optical-coherence-tomography-based-angiography-in-retinal-artery-occlusion-in-children
#5
Wojciech Hautz, Joanna Gołębiewska, Agnieszka Czeszyk-Piotrowicz
PURPOSE: To evaluate the role of optical coherence tomography (OCT)-based angiography (OCTA) in the diagnosis and monitoring of pediatric patients with retinal artery occlusion (RAO). MATERIAL AND METHODS: This retrospective study was conducted at the Department of Ophthalmology, The Children's Memorial Health Institute, in Warsaw between March 2015 and May 2016. Every patient underwent a complete ophthalmological examination. The diagnosis of the disease was based on fundus examination and fluorescein angiography (FA)...
January 24, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29381739/impaired-memory-is-more-closely-associated-with-brain-beta-amyloid-than-leukoaraiosis-in-hypertensive-patients-with-cognitive-symptoms
#6
Eric E Smith, Alona Muzikansky, Cheryl R McCreary, Saima Batool, Anand Viswanathan, Bradford C Dickerson, Keith Johnson, Steven M Greenberg, Deborah Blacker
BACKGROUND: Hypertension is the strongest modifiable risk factor for subcortical ischemic changes and is also a risk factor for Alzheimer's dementia. We used neuroimaging to investigate the pathological basis of early cognitive symptoms in patients with hypertension. METHODS: In this cross-sectional cohort study 67 patients age >60 years with hypertension and Clinical Dementia Rating scale score of 0.5 without dementia, and without history of symptomatic stroke, underwent MRI for measurement of subcortical vascular changes and positron emission tomography (PET) scan with Pittsburgh Compound B (PiB-PET) to detect beta-amyloid deposition...
2018: PloS One
https://www.readbyqxmd.com/read/29357019/disruption-to-the-5-ht7-receptor-following-hypoxia-ischemia-in-the-immature-rodent-brain
#7
Julie A Wixey, Hanna E Reinebrant, Kirat K Chand, Kathryn M Buller
It has become increasingly evident the serotonergic (5-hydroxytryptamine, 5-HT) system is an important central neuronal network disrupted following neonatal hypoxic-ischemic (HI) insults. Serotonin acts via a variety of receptor subtypes that are differentially associated with behavioural and cognitive mechanisms. The 5-HT7 receptor is purported to play a key role in epilepsy, anxiety, learning and memory and neuropsychiatric disorders. Furthermore, the 5-HT7 receptor is highly localized in brain regions damaged following neonatal HI insults...
January 22, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29354568/anatomical-correlates-of-neuropsychological-deficits-among-patients-with-the-cerebellar-stroke
#8
Min A Shin, Oak Tae Park, Joon-Ho Shin
Objective: To investigate the anatomical correlates of the neuropsychological deficits in patients with the cerebellar stroke. Methods: We screened patients who were admitted to the National Rehabilitation Center with the cerebellar stroke between October 2012 and November 2016. The patients with the cerebellar stroke who underwent neuropsychological testing for which the Seoul Neuropsychological Screening Battery (SNSB) or the SNSB-II were enrolled. The neuropsychological function capacities were compared in accordance with the stroke type (hemorrhagic vs...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29354228/severe-episodic-memory-impairment-after-strategic-infarct-a-case-report
#9
Francisco Wilson Nogueira Holanda, Katie Moraes de Almondes, Rodrigo Alencar E Silva
Brain infarcts located in strategic regions often result in cognitive impairment. Based on a case study, this paper describes unusual and specific clinical and neuropsychological features of a strategic ischemic lesion in the left medial temporal lobe (MTL) structures. Taken together with the literature data, the case illustrates that a unilateral strategic infarct in MTL structures may result in severe impairment of episodic memory (EM), which refers to the ability to encode and retrieve personal experiences, including information about the time and place of an event and detailed description of the event itself...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29341891/long-term-treadmill-exercise-improves-memory-impairment-through-restoration-of-decreased-synaptic-adhesion-molecule-1-2-3-induced-by-transient-cerebral-ischemia-in-the-aged-gerbil-hippocampus
#10
Ji Hyeon Ahn, Joon Ha Park, Jinseu Park, Myoung Cheol Shin, Jun Hwi Cho, In Hye Kim, Jeong-Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Bich Na Shin, Young-Myeong Kim, Choong Hyun Lee, In Koo Hwang, Il Jun Kang, Bai Hui Chen, Bing Chun Yan, Young Joo Lee, Moo-Ho Won, Soo Young Choi
Exercise improves cognitive impairments induced by transient cerebral ischemia and modulates synaptic adhesion molecules. In this study, we investigated effects of long-term treadmill exercise on cognitive impairments and its relation to changes of synaptic cell adhesion molecule (SynCAM) 1/2/3 in the hippocampus after 5 min of transient cerebral ischemia in aged gerbils. Animals were assigned to sedentary and exercised groups, given treadmill exercise for 4 consecutive weeks from 5 days after transient ischemia and evaluated cognitive function through passive avoidance test and Morris water maze test...
January 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29338604/clinical-significance-of-cerebral-microbleeds-on-mri-a-comprehensive-meta-analysis-of-risk-of-intracerebral-hemorrhage-ischemic-stroke-mortality-and-dementia-in-cohort-studies-v1
#11
Andreas Charidimou, Sara Shams, Jose R Romero, Jie Ding, Roland Veltkamp, Solveig Horstmann, Gudny Eiriksdottir, Mark A van Buchem, Vilmundur Gudnason, Jayandra J Himali, M Edip Gurol, Anand Viswanathan, Toshio Imaizumi, Meike W Vernooij, Sudha Seshadri, Steven M Greenberg, Oscar R Benavente, Lenore J Launer, Ashkan Shoamanesh
Background Cerebral microbleeds can confer a high risk of intracerebral hemorrhage, ischemic stroke, death and dementia, but estimated risks remain imprecise and often conflicting. We investigated the association between cerebral microbleeds presence and these outcomes in a large meta-analysis of all published cohorts including: ischemic stroke/TIA, memory clinic, "high risk" elderly populations, and healthy individuals in population-based studies. Methods Cohorts (with > 100 participants) that assessed cerebral microbleeds presence on MRI, with subsequent follow-up (≥3 months) were identified...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29286319/cellular-and-molecular-mechanisms-underlying-non-pharmaceutical-ischemic-stroke-therapy-in-aged-subjects
#12
REVIEW
Raluca Elena Sandu, Danut Dumbrava, Roxana Surugiu, Daniela-Gabriela Glavan, Andrei Gresita, Eugen Bogdan Petcu
The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29283314/delayed-inhibition-of-tonic-inhibition-enhances-functional-recovery-following-experimental-ischemic-stroke
#13
James E Orfila, Himmat Grewal, Robert M Dietz, Frank Strnad, Takeru Shimizu, Myriam Moreno, Christian Schroeder, Joan Yonchek, Krista M Rodgers, Andra Dingman, Timothy J Bernard, Nidia Quillinan, Wendy B Macklin, Richard J Traystman, Paco S Herson
The current study focuses on the ability to improve cognitive function after stroke with interventions administered at delayed/chronic time points. In light of recent studies demonstrating delayed GABA antagonists improve motor function, we utilized electrophysiology, biochemistry and neurobehavioral methods to investigate the role of α5 GABAA receptors on hippocampal plasticity and functional recovery following ischemic stroke. Male C57Bl/6 mice were exposed to 45 min transient middle cerebral artery occlusion and analysis of synaptic and functional deficits performed 7 or 30 days after recovery...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29258727/the-role-of-preliminary-hospitals-in-the-management-of-a-mass-burn-casualty-disaster
#14
Ling-Wei Kuo, Cheng-I Yen, Chih-Yuan Fu, Chun-Hao Pan, Chih-Po Hsu, Yen-Chang Hsiao, Chi-Hsun Hsieh, Yu-Pao Hsu
PURPOSE: The Formosa Fun Coast explosion is an internationally-known event that occurred in Taiwan on June 27th, 2015. The blast involved 495 casualties in total, with 253 patients receiving 2nd degree or deeper burns on greater than 40% of the total body surface area (TBSA). Questions were raised regarding whether these victims were sent to the appropriate hospitals or not. Therefore, we analyzed the effect of the initial admission destination in this study. MATERIAL AND METHODS: We retrospectively reviewed all of the victims from the explosion who were sent to the emergency department of Linkou and Keelung Chang Gung Memorial Hospitals...
December 16, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29258335/targeting-of-microbubbles-contrast-agents-for-ultrasound-molecular-imaging
#15
Shiying Wang, John A Hossack, Alexander L Klibanov
For contrast ultrasound imaging, the most efficient contrast agents comprise highly compressible gas-filled microbubbles. These micrometer-sized particles are typically filled with low-solubility perfluorocarbon gases, and coated with a thin shell, often a lipid monolayer. These particles circulate in the bloodstream for several minutes; they demonstrate good safety and are already in widespread clinical use as blood pool agents with very low dosage necessary (sub-mg per injection). As ultrasound is an ubiquitous medical imaging modality, with tens of millions of exams conducted annually, its use for molecular/targeted imaging of biomarkers of disease may enable wider implementation of personalized medicine applications, precision medicine, non-invasive quantification of biomarkers, targeted guidance of biopsy and therapy in real time...
December 20, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29222024/continuous-and-not-continuous-2-week-treadmill-training-enhances-the-performance-in-the-passive-avoidance-test-in-ischemic-gerbils
#16
Ana Paula Cassiano Silveira, Takae Tamy Kitabatake, Vivian Mozol Pantaleo, Hélio Zangrossi, Guilherme Bertolino, Elaine Caldeira de Oliveira Guirro, Hugo Celso Dutra de Souza, João Eduardo de Araujo
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29221967/improving-cognitive-function-in-patients-with-stroke-can-computerized-training-be-the-future
#17
Rosaria De Luca, Simona Leonardi, Letteria Spadaro, Margherita Russo, Bianca Aragona, Michele Torrisi, Maria Grazia Maggio, Alessia Bramanti, Antonino Naro, Maria Cristina De Cola, Rocco Salvatore Calabrò
BACKGROUND: Cognitive impairment after stroke is common and can cause disability with a high impact on quality of life and independence. Cognitive rehabilitation is a therapeutic approach designed to improve cognitive functioning after central nervous system's injuries. Computerized cognitive rehabilitation (CCR) uses multimedia and informatics resources to optimize cognitive compromised performances. The aim of this study is to evaluate the effects of pc cognitive training with Erica software in patients with stroke...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29218785/increased-affinity-of-endothelial-cells-to-niti-using-ultraviolet-irradiation-an-in-vitro-study
#18
Satoshi Tateshima, Naoki Kaneko, Masahiro Yamada, Gary Duckwiler, Fernando Vinuela, Takahiro Ogawa
Nickel - Titanium alloy (NiTi) is one of the most popular materials used endovascularly because of its shape memory and superelasticity. The NiTi device needs to be covered by endothelial cells after being placed in the blood vessel to reduce ischemic complications. The objective of this study was to examine the impact of ultraviolet (UV) irradiation on the biocompatibility of NiTi surfaces with endothelial cells. NiTi sheets were treated with UV irradiation for 48 hours and human aorta derived endothelial cells were used in this study...
December 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29215306/a-peptide-mimetic-of-tyrosine-phosphatase-step-as-a-potential-therapeutic-agent-for-treatment-of-cerebral-ischemic-stroke
#19
Ranjana Poddar, Sathyanarayanan Rajagopal, Lucas Winter, Andrea M Allan, Surojit Paul
Extensive research over the last two decades has advanced our understanding of the pathophysiology of ischemic stroke. However, current pharmacologic therapies are still limited to rapid reperfusion using thrombolytic agents, and neuroprotective approaches that can reduce the consequences of ischemic and reperfusion injury, are still not available. To bridge this gap, we have evaluated the long-term efficacy and therapeutic time window of a novel peptide-based neuroprotectant TAT-STEP, derived from the brain-enriched and neuron-specific tyrosine phosphatase STEP...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#20
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
December 4, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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