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https://www.readbyqxmd.com/read/28508173/neuroprotective-effects-of-lycium-barbarum-polysaccharide-on-focal-cerebral-ischemic-injury-in-mice
#1
Peng Zhao, Ru Zhou, Xiao-Yun Zhu, Gang Liu, Yu-Ping Zhao, Peng-Sheng Ma, Wei Wu, Yang Niu, Tao Sun, Yu-Xiang Li, Jian-Qiang Yu, Zhong-Ming Qian
Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory deficits. We recently indicated that LBP exerts neuroprotective effect against focal cerebral ischemic injury in mice via attenuating the mitochondrial apoptosis pathway. The aim of this study was to investigate the neuroprotective effects of LBP against the behavioral dysfunction induced by focal cerebral ischemia injury in mice...
May 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28506806/selective-associative-phonagnosia-after-right-anterior-temporal-stroke
#2
Simona Luzzi, Michela Coccia, Gabriele Polonara, Carlo Reverberi, Gabriella Ceravolo, Mauro Silvestrini, Fabio Fringuelli, Sara Baldinelli, Leandro Provinciali, Guido Gainotti
We report the case of a 48 year old men who developed a selective impairment in famous voice recognition after ischemic stroke in right subcortical structures (lenticular nucleus and head of the caudate) and right anterior temporal lobe. He underwent fibrinolytic treatment. During the following days he progressively recovered and was discharged without neurological focal sign. Patent foramen ovale was found. When he got back to his house he noticed that he was unable to recognize the voice of his favoured singers and needed to ask who was the singer to his relatives...
May 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28502261/profiles-of-executive-function-across-children-with-distinct-brain-disorders-traumatic-brain-injury-stroke-and-brain-tumor
#3
Gabriel C Araujo, Tanya N Antonini, Vicki Anderson, Kathryn A Vannatta, Christina G Salley, Erin D Bigler, H Gerry Taylor, Cynthia Gerhardt, Kenneth Rubin, Maureen Dennis, Warren Lo, Mark T Mackay, Anne Gordon, Christine Hajek Koterba, Alison Gomes, Mardee Greenham, Keith Owen Yeates
OBJECTIVES: This study examined whether children with distinct brain disorders show different profiles of strengths and weaknesses in executive functions, and differ from children without brain disorder. METHODS: Participants were children with traumatic brain injury (N=82; 8-13 years of age), arterial ischemic stroke (N=36; 6-16 years of age), and brain tumor (N=74; 9-18 years of age), each with a corresponding matched comparison group consisting of children with orthopedic injury (N=61), asthma (N=15), and classmates without medical illness (N=68), respectively...
May 15, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28502042/tale-of-the-good-and-the-bad-cdk5-remodeling-of-the-actin-cytoskeleton-in-the-brain
#4
REVIEW
Kavita Shah, Sandra Rossie
Cdk5 kinase, a cyclin-dependent kinase family member, is a key regulator of cytoskeletal remodeling in the brain. Cdk5 is essential for brain development during embryogenesis. After birth, it is essential for numerous neuronal processes such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity is deregulated in various brain disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and ischemic stroke, resulting in profound remodeling of the neuronal cytoskeleton, loss of synapses, and ultimately neurodegeneration...
May 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28501693/necrostatin-1-protects-hippocampal-neurons-against-ischemia-reperfusion-injury-via-the-rip3-daxx-signaling-pathway-in-rats
#5
Rongli Yang, Kun Hu, Jieyun Chen, Shiguang Zhu, Lei Li, Hailong Lu, Pingjing Li, Ruiguo Dong
Global cerebral ischemia/reperfusion (I/R) induces selective neuronal injury in CA1 region of hippocampus, leading to severe impairment in behavior, learning and memory functions. However, the molecular mechanism underlying the processes was not elucidated clearly. RIP3 is a key molecular switch connecting apoptosis, necrosis and necroptosis. DAXX, as a novel substrate of RIP3, plays a vital role in ischemia-induced neuronal death. The aim of this study is to investigate the role and mechanism of RIP3/DAXX signaling pathway on neurons in CA1 region of the rat hippocampus after cerebral I/R...
May 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28499951/effects-of-task-specific-rehabilitation-training-on-tau-modification-in-rat-with-photothrombotic-cortical-ischemic-damage
#6
Kyung-Lim Joa, Sohee Moon, Ji-Hye Kim, Dong Wun Shin, Kyoung-Hee Lee, Seon Jung, Myeong-Ok Kim, Chang-Hwan Kim, Han-Young Jung, Ju-Hee Kang
Although stroke elicits progressive cognitive decline and is a leading cause of dementia, molecular interplay between stroke and Alzheimer's disease (AD) pathology has not been fully elucidated. Furthermore, studies on the effects of post-stroke rehabilitation on AD pathology are limited. We evaluated the acute effect of stroke on tau modification, and the molecular effects of task-specific training (TST) on tau modification using a model of photochemically-induced thrombosis (PIT)-induced cortical infarction...
May 9, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28495306/long-term-effects-of-enriched-environment-following-neonatal-hypoxia-ischemia-on-behavior-bdnf-and-synaptophysin-levels-in-rat-hippocampus-effect-of-combined-treatment-with-g-csf
#7
Myrsini Griva, Rosa Lagoudaki, Olga Touloumi, Evangelia Nousiopoulou, Filippos Karalis, Thomas Georgiou, Georgia Kokaraki, Constantina Simeonidou, Despina A Tata, Evangelia Spandou
Increasing evidence shows that exposure to an enriched environment (EE) is neuroprotective in adult and neonatal animal models of brain ischemia. However, the mechanisms underlying this effect remain unclear. The aim of the current study was to investigate whether post-weaning EE would be effective in preventing functional deficits and brain damage by affecting markers of synaptic plasticity in a neonatal rat model of hypoxia-ischemia (HI). We also examined the possibility that granulocyte-colony stimulating factor (G-CSF), a growth factor with known neuroprotective effects in a variety of experimental brain injury models, combined with EE stimulation could enhance the potential beneficial effect of EE...
May 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28490880/protective-efficacy-of-a-single-salvianolic-acid-a-treatment-on-photothrombosis-induced-sustained-spatial-memory-impairments
#8
Chun-Xiang Jiao, Heng Zhou, Chun-Xian Yang, Chen Ma, Yue-Xiong Yang, Rong-Rong Mao, Lin Xu, Qi-Xin Zhou
With respect to the high burden of ischemic stroke and the absence of pharmacological treatment for promoting rehabilitation, promising candidates with specific effects on long-term functional recovery are highly desired. Candidates need reasonable experimental paradigms to evaluate the long-term functional outcome focused on ischemia-induced sensorimotor and memory deficits. "Danshen", a traditional Chinese herb, has long been used to treat coronary and cerebral vascular diseases as well as dementia. Salvianolic acid A (SAA), one of the major active ingredients of Danshen, was demonstrated to be effective in protecting against cerebral ischemic injury...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28487337/haptoglobin-hp2-variant-promotes-premature-cardiovascular-death-in-stroke-survivors
#9
Petra Ijäs, Susanna Melkas, Jani Saksi, Antti Jula, Matti Jauhiainen, Niku Oksala, Tarja Pohjasvaara, Markku Kaste, Pekka J Karhunen, Perttu Lindsberg, Timo Erkinjuntti
BACKGROUND AND PURPOSE: Haptoglobin (Hp) is an acute phase plasma protein protecting tissues from oxidative damage. It exists in 2 variant alleles (hp1/hp2) giving rise to 3 protein isoforms with different biochemical properties and efficiency to limit oxidative stress. We previously found that hp2 variant is associated with stroke risk in the patients with carotid stenosis and the risk of ischemic cardiovascular events in a general population cohort. This study examined the hypothesis that Hp genotype is associated with general cardiovascular risk in patients with stroke...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28465087/supplementation-with-different-teas-from-camellia-sinensis-prevents-memory-deficits-and-hippocampus-oxidative-stress-in-ischemia-reperfusion
#10
Alexandre Martins, Helen L Schimidt, Alexandre Garcia, Caroline Dalla Colletta Altermann, Francielli W Santos, Felipe P Carpes, Weber Cláudio da Silva, Pâmela B Mello-Carpes
Memory and cognition impairments resultant of ischemic stroke could be minimized or avoided by antioxidant supplementation. In this regard, the neuroprotective potential of Green tea from Camellia sinensis has been investigated. However, there is a lack of information regarding the neuroprotective potential of others teas processed from the Camellia sinensis. Here we investigate the neuroprotective role of green, red, white and black tea on memory deficits and brain oxidative stress in a model of ischemic stroke in rats...
April 29, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28438578/global-cerebral-ischemia-in-rats-leads-to-amnesia-due-to-selective-neuronal-death-followed-by-astroglial-scar-formation-in-the-ca1-layer
#11
Kevin Sadelli, Jean-Claude Stamegna, Stéphane D Girard, Nathalie Baril, Guy Escoffier, Maïna Brus, Antoine D Véron, Michel Khrestchatisky, François S Roman
Global Cerebral Ischemia (GCI) occurs following cardiac arrest or neonatal asphyxia and leads to harmful neurological consequences. In most cases, patients who survive cardiac arrest develop severe cognitive and motor impairments. This study focused on learning and memory deficits associated with brain neuroanatomical reorganization that appears after GCI. The four-vessel occlusion (4VO) model was performed to produce a transient GCI. Hippocampal lesions in ischemic rats were visualized using anatomical Magnetic Resonance Imaging (aMRI)...
April 21, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28438076/increased-work-and-social-engagement-is-associated-with-increased-stroke-specific-quality-of-life-in-stroke-survivors-at-3%C3%A2-months-and-12-months-post-stroke-a-longitudinal-study-of-an-australian-stroke-cohort
#12
Tamara Tse, Siti Zubaidah Binte Yusoff, Leonid Churilov, Henry Ma, Stephen Davis, Geoffrey Alan Donnan, Leeanne M Carey
BACKGROUND: There is a relative lack of longitudinal studies investigating stroke-specific outcomes and quality of life (QOL). This study aimed to identify which factors (level of disability, cognitive functioning, depressive symptoms, physical activity, and work and social engagement) were independently associated with each stroke-specific domain of QOL, adjusting for age and gender, at 3 months and 12 months post-stroke in an Australian cohort. METHOD: Survivors of ischemic stroke were recruited from 18 sites of the STroke imAging pRevention and Treatment (START) longitudinal cohort study...
April 24, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28431607/sigma-1-receptor-in-brain-ischemia-reperfusion-possible-role-in-the-nr2a-induced-pathway-to-regulate-brain-derived-neurotrophic-factor
#13
Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zou
Sigma-1 receptor (σ1r) activation could attenuate the learning and memory deficits in the AD model, ischemia model and others. In our previous study, the activation of σ1r increased the expression of brain-derived neurotrophic factor (BDNF), possibly through the NR2A-induced pathway, and σ1r agonists might function as neuroprotectant agents in vascular dementia. Here, we used σ1r knockout mice to confirm the role of σ1r. Furthermore, an antagonist of NR2A was first used to investigate whether the NR2A-induced pathway is the necessary link between σ1r and BDNF...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427203/regional-structural-impairments-outside-lesions-are-associated-with-verbal-short-term-memory-deficits-in-chronic-subcortical-stroke
#14
Qingqing Diao, Jingchun Liu, Caihong Wang, Jingliang Cheng, Tong Han, Xuejun Zhang
BACKGROUND AND PURPOSE: We aimed to explore the neural mechanisms of verbal short-term memory (VSTM) impairment in subcortical stroke by evaluating the contributions of lesion and remote grey matter volume (GMV) reduction. RESULTS: There was no significant correlation between lesions and VSTM. In stroke patients with left lesions, GMV reductions in the right middle frontal gyrus and in the left inferior frontal gyrus were positively correlated with VSTM impairment...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424610/characterizing-brain-iron-deposition-in-patients-with-subcortical-vascular-mild-cognitive-impairment-using-quantitative-susceptibility-mapping-a-potential-biomarker
#15
Yawen Sun, Xin Ge, Xu Han, Wenwei Cao, Yao Wang, Weina Ding, Mengqiu Cao, Yong Zhang, Qun Xu, Yan Zhou, Jianrong Xu
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment as indicated by z-scores. We recruited 20 subcortical ischemic vascular disease (SIVD) patients who fulfilled the criteria for svMCI...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28422578/korean-version-of-the-mini-mental-state-examination-using-smartphone-a-validation-study
#16
Hae-Yeon Park, Sung-Soo Jeon, Jin-Youn Lee, Ah-Ra Cho, Joo Hyun Park
BACKGROUND: Stroke often leads to disability, and poststroke survivors often have limited accessibility to medical facilities. INTRODUCTION: For such patients, mobile videoconferencing technology offers an opportunity to perform follow-up assessment and appropriate management of cognitive impairment. We aimed to determine the validity of the Korean version of the Mini-Mental State Examination (MMSE-K) when administered using a smartphone. MATERIALS AND METHODS: Thirty patients with ischemic or hemorrhagic stroke were included in this study (20 males, 10 females; mean age, 69...
April 19, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28416406/acute-stroke-despite-dabigatran-anticoagulation-treated-with-idarucizumab-and-intravenous-tissue-plasminogen-activator
#17
David Bissig, Rashmi Manjunath, Brittany R Traylor, David P Richman, Kwan L Ng
Dabigatran is a direct thrombin inhibitor used to reduce the risk of stroke in patients with nonvalvular atrial fibrillation. For patients who present with an acute stroke despite dabigatran therapy, clinical data on the use of intravenous tissue plasminogen activator (IV-tPA) is limited. There is an anticipated increased risk of symptomatic intracranial hemorrhage (sICH) when using IV-tPA in patients on dabigatran therapy. In 2015, the humanized monoclonal antibody fragment idarucizumab was approved for rapid (minutes) reversal of anticoagulant effects of dabigatran...
April 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28382852/cardiorespiratory-fitness-cognition-and-brain-structure-after-tia-or-minor-ischemic-stroke
#18
H Myrthe Boss, Sander M Van Schaik, Theo D Witkamp, Mirjam I Geerlings, Henry C Weinstein, Renske M Van den Berg-Vos
Background It is not known whether cardiorespiratory fitness is associated with better cognitive performance and brain structure in patients with a TIA or minor ischemic stroke. Aims To examine the association between cardiorespiratory fitness, cognition and brain structure in patients with a TIA and minor stroke. Methods The study population consisted of patients with a TIA or minor stroke with a baseline measurement of the peak oxygen consumption, a MRI scan of brain and neuropsychological assessment. Composite z-scores were calculated for the cognitive domains attention, memory and executive functioning...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28271640/neuroprotective-effect-of-lacosamide-on-hypoxic-ischemic-brain-injury-in-neonatal-rats
#19
Gun Ha Kim, Jung Hye Byeon, Baik Lin Eun
BACKGROUND AND PURPOSE: Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of traumatic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury. METHODS: We divided rats into three groups at each testing session: pre- or postfed with LCM, fed with normal saline, and sham...
April 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28271403/combination-treatment-with-methylene-blue-and-hypothermia-in-global-cerebral-ischemia
#20
Lei Li, Rongli Yang, Pingjing Li, Hailong Lu, Jingbo Hao, Liyan Li, Donovan Tucker, Quanguang Zhang
Therapeutic hypothermia (TH) is the most potent therapeutic strategy for global cerebral ischemia (GCI), usually induced by cardiac arrest. TH has been shown both to suppress the delayed neuronal cell death in the vulnerable hippocampal CA1 subregion and to improve neurological outcomes in experimental animals after GCI. However, given the multiple adverse effects resulting from TH, application of such a therapy is typically limited. In recent years, methylene blue (MB) has emerged as a potential therapeutic drug for the treatment of neurodegenerative diseases...
March 7, 2017: Molecular Neurobiology
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