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ischemic memory

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https://www.readbyqxmd.com/read/29036822/cortical-cerebral-microinfarcts-on-3-tesla-mri-in-patients-with-vascular-cognitive-impairment
#1
Doeschka A Ferro, Susanne J van Veluw, Huiberdina L Koek, Lieza G Exalto, Geert Jan Biessels
BACKGROUND: Cerebral microinfarcts (CMIs) are small ischemic lesions that are a common neuropathological finding in patients with stroke or dementia. CMIs in the cortex can now be detected in vivo on 3 Tesla MRI. OBJECTIVE: To determine the occurrence of CMIs and associated clinical features in patients with possible vascular cognitive impairment (VCI). METHOD: 182 memory-clinic patients (mean age 71.4±10.6, 55% male) with vascular injury on brain MRI (i...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29034421/hippocampal-deformations-and-entorhinal-cortex-atrophy-as-an-anatomical-signature-of-long-term-cognitive-impairment-from-the-mcao-rat-model-to-the-stroke-patient
#2
C Delattre, C Bournonville, F Auger, R Lopes, C Delmaire, H Henon, A M Mendyk, S Bombois, J C Devedjian, D Leys, C Cordonnier, R Bordet, M Bastide
Stroke patients have an elevated risk of developing long-term cognitive disorders or dementia. The latter is often associated with atrophy of the medial temporal lobe. However, it is not clear whether hippocampal and entorhinal cortex atrophy is the sole predictor of long-term post-stroke dementia. We hypothesized that hippocampal deformation (rather than atrophy) is a predictive marker of long-term post-stroke dementia on a rat model and tested this hypothesis in a prospective cohort of stroke patients.Male Wistar rats were subjected to transient middle cerebral artery occlusion and assessed 6 months later...
October 16, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29026580/-123-i-bmipp-single-photon-emission-computed-tomography-for-diagnosing-chest-pain-in-patients-with-nonobstructive-coronary-angiograms-takotsubo-or-vasospasm
#3
Yuta Seko, Kenichi Sasaki, Takao Kato, Moriaki Inoko
The decreased 123I-BMIPP uptake, while having normal perfusion, in the correspondent coronary artery territory is caused by a delayed metabolic recovery after the recovery of perfusion. This phenomenon termed ischemic memory can clearly differentiate vasospastic angina from other chest pain syndromes.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29021742/neuroprotective-mechanisms-of-lycium-barbarum-polysaccharides-against-ischemic-insults-by-regulating-nr2b-and-nr2a-containing-nmda-receptor-signaling-pathways
#4
Zhongshan Shi, Lihui Zhu, Tingting Li, Xiaoya Tang, Yonghui Xiang, Xinjia Han, Luoxing Xia, Ling Zeng, Junhua Nie, Yongxia Huang, Chi Kwan Tsang, Ying Wang, Zhigang Lei, Zaocheng Xu, Kwok-Fai So, Yiwen Ruan
Glutamate excitotoxicity plays an important role in neuronal death after ischemia. However, all clinical trials using glutamate receptor inhibitors have failed. This may be related to the evidence that activation of different subunit of NMDA receptor will induce different effects. Many studies have shown that activation of the intrasynaptic NR2A subunit will stimulate survival signaling pathways, whereas upregulation of extrasynaptic NR2B will trigger apoptotic pathways. A Lycium barbarum polysaccharide (LBP) is a mixed compound extracted from Lycium barbarum fruit...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29021365/lactic-acid-no-longer-an-inert-and-end-product-of-glycolysis
#5
REVIEW
Shiren Sun, Heng Li, Jianghua Chen, Qi Qian
For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.
November 2017: Physiology
https://www.readbyqxmd.com/read/29017492/electroacupuncture-ameliorating-post-stroke-cognitive-impairments-via-inhibition-of-peri-infarct-astroglial-and-microglial-macrophage-p2-purinoceptors-mediated-neuroinflammation-and-hyperplasia
#6
Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao, Lidian Chen
BACKGROUND: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28977360/cognitive-function-and-changes-in-cognitive-function-as-predictors-of-incident-cardiovascular-disease-the-women-s-health-initiative-memory-study
#7
Xiaoyan Leng, Mark A Espeland, JoAnn E Manson, Marcia L Stefanick, Emily W Gower, Kathleen M Hayden, Marian C Limacher, Leslie Vaughan, Jennifer Robinson, Robert Wallace, Sylvia Wassertheil-Smoller, Kristine Yaffe, Sally A Shumaker
Background: Cognitive impairment and decline may signal the increased risk of incident cardiovascular disease (CVD). We examined associations of global cognitive function, as measured by the Modified Mini-Mental State Examination (3MS) and changes in 3MS over time, with incident CVD, individual CVD outcomes, CVD death, and all-cause mortality. Methods: A total of 5,596 women (≥ 60) from the Women's Health Initiative Memory Study free of CVD at baseline were followed for an average of 7...
July 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28970969/slower-eeg-alpha-generation-synchronization-and-flow-possible-biomarkers-of-cognitive-impairment-and-neuropathology-of-minor-stroke
#8
Jelena Petrovic, Vuk Milosevic, Miroslava Zivkovic, Dragan Stojanov, Olga Milojkovic, Aleksandar Kalauzi, Jasna Saponjic
BACKGROUND: We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke neuropathology and cognitive functions in the subacute and chronic stages of minor strokes. METHODS: We included 10 patients with right middle cerebral artery (MCA) ischemic strokes and 11 healthy controls. All the assessments of stroke patients were done both in the subacute and chronic stages. Neurological impairment was measured using the National Institute of Health Stroke Scale (NIHSS), whereas cognitive functions were assessed using the Montreal Cognitive Assessment (MoCA) and MoCA memory index (MoCA-MIS)...
2017: PeerJ
https://www.readbyqxmd.com/read/28968811/human-parahippocampal-cortex-supports-spatial-binding-in-visual-working-memory
#9
Neil Michael Dundon, Mohammad Zia Ul Haq Katshu, Bronson Harry, Daniel Roberts, E Charles Leek, Paul Downing, Ayelet Sapir, Craig Roberts, Giovanni d'Avossa
Studies investigating the functional organization of the medial temporal lobe (MTL) suggest that parahippocampal cortex (PHC) generates representations of spatial and contextual information used by the hippocampus in the formation of episodic memories. However, evidence from animal studies also implicates PHC in spatial binding of visual information held in short term, working memory. Here we examined a 46-year-old man (P.J.), after he had recovered from bilateral medial occipitotemporal cortex strokes resulting in ischemic lesions of PHC and hippocampal atrophy, and a group of age-matched healthy controls...
September 15, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28962173/tetramethylpyrazine-reduces-blood-brain-barrier-permeability-associated-with-enhancement-of-peripheral-cholinergic-anti-inflammatory-effects-for-treating-traumatic-brain-injury
#10
Aimin Wang, Guangbin Zhu, Ping Qian, Tao Zhu
Traumatic brain injury (TBI) is a diverse group of intracranial injuries resulting from external mechanical insults to the brain. While basic and clinical research for TBI has been conducted for decades, it has not identified cost-effective medical interventions for treating TBI. Tetramethylpyrazine (TMP), which is derived from the Chinese herb, Ligusticum chuanxiong Hort (Chuan Xiong), has been clinically used for treating ischemic brain injury for years. However, whether TMP could provide effective benefits for improving the outcomes following TBI is unknown...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28956204/high-flow-bypass-with-radial-artery-graft-followed-by-internal-carotid-artery-ligation-for-large-or-giant-aneurysms-of-cavernous-or-cervical-portion-clinical-results-and-cognitive-performance
#11
Hideaki Ono, Tomohiro Inoue, Takeo Tanishima, Akira Tamura, Isamu Saito, Nobuhito Saito
High-flow bypass followed by ligation of the internal carotid artery (ICA) is an effective treatment, but the impact of abrupt occlusion of the ICA is unpredictable, especially on postoperative cognitive function. The present study evaluated the clinical results as well as cognitive performances after high-flow bypass using radial artery graft (RAG) with supportive superficial temporal artery (STA)-middle cerebral artery (MCA) bypass, followed by ICA ligation. Ten consecutive patients underwent high-flow bypass surgery for large or giant ICA aneurysms of cavernous or cervical portion...
September 27, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28944854/effect-of-hippocampal-l%C3%A2-nbp-on-bdnf-and-trkb-expression-and-neurological-function-of-vascular-dementia-rats
#12
Yujing Huang, Zhaohui Li, Guangxian Nan
The pathogenesis of vascular dementia (VD) is associated with neuronal degeneration, apoptosis or necrosis following ischemic brain injury. L‑butylphthalide (L‑NBP), has been demonstrated to exhibit potent anti‑ischemic and anti‑VD effects, however the associated specific mechanism remains to be elucidated. The present study generated a VD rat model, in which the effect of L‑NBP on neurological function and expression levels of brain‑derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) were observed...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28934194/arginine-vasopressin-ameliorates-spatial-learning-impairments-in-chronic-cerebral-hypoperfusion-via-v1a-receptor-and-autophagy-signaling-partially
#13
C Yang, X Zhang, J Gao, M Wang, Z Yang
Chronic cerebral hypoperfusion (CCH) is a major factor contributing to neurological disorders and cognitive decline. Autophagy activation is believed to provide both beneficial and detrimental roles during hypoxic/ischemic cellular injury. Although arginine vasopressin (AVP) has been strongly involved in many behaviors, especially in learning and memory, the effects of AVP on CCH and their molecular mechanisms remain unclear. Here, to investigate whether there was neuroprotective effects of AVP on CCH through V1a receptor (an AVP receptor) signaling, permanent bilateral carotid arteries occlusion (two vessel occlusion, 2VO) was used to establish a rat model of CCH, and hypertonic saline (5...
July 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28931035/neuroprotection-with-hypothermia-and-allopurinol-in-an-animal-model-of-hypoxic-ischemic-injury-is-it-a-gender-question
#14
COMPARATIVE STUDY
Javier Rodríguez-Fanjul, Cristina Durán Fernández-Feijóo, Míriam Lopez-Abad, Maria Goretti Lopez Ramos, Rafael Balada Caballé, Soledad Alcántara-Horillo, Marta Camprubí Camprubí
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ischemic injury (HI). Despite this, TH does not provide complete neuroprotection. Allopurinol seems to be a good neuroprotector in several animal studies, but it has never been tested in combination with hypothermia. Clinical findings show that male infants with (HI) fare more poorly than matched females in cognitive outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28922154/atrial-fibrillation-is-independently-associated-with-cognitive-impairment-after-ischemic-stroke
#15
Russell Jude Chander, Levinia Lim, Sagarika Handa, Shaun Hiu, Angeline Choong, Xuling Lin, Rajinder Singh, Daniel Oh, Nagaendran Kandiah
BACKGROUND: While atrial fibrillation (AF) is an important risk factor for ischemic strokes and mild cognitive impairment (MCI) in Alzheimer's disease, the association between AF and post-stroke cognitive impairment (PSCI), and the factors mediating this association, is unclear. OBJECTIVE: To investigate the role of AF in PSCI, especially in relation to other markers of cerebrovascular disease. METHODS: 445 subjects with mild ischemic stroke without pre-stroke cognitive decline were assessed 3-6 months post-stroke for cognitive deficits...
September 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28910298/adult-hippocampal-neurogenesis-poststroke-more-new-granule-cells-but-aberrant-morphology-and-impaired-spatial-memory
#16
Florus Woitke, Mihai Ceanga, Max Rudolph, Fanny Niv, Otto W Witte, Christoph Redecker, Albrecht Kunze, Silke Keiner
Stroke significantly stimulates neurogenesis in the adult dentate gyrus, though the functional role of this postlesional response is mostly unclear. Recent findings suggest that newborn neurons generated in the context of stroke may fail to correctly integrate into pre-existing networks. We hypothesized that increased neurogenesis in the dentate gyrus following stroke is associated with aberrant neurogenesis and impairment of hippocampus-dependent memory. To address these questions we used the middle cerebral artery occlusion model (MCAO) in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28895445/strategic-infarct-location-for-post-stroke-cognitive-impairment-a-multivariate-lesion-symptom-mapping-study
#17
Lei Zhao, J Matthijs Biesbroek, Lin Shi, Wenyan Liu, Hugo J Kuijf, Winnie Wc Chu, Jill M Abrigo, Ryan Kl Lee, Thomas Wh Leung, Alexander Yl Lau, Geert J Biessels, Vincent Mok, Adrian Wong
Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28882820/high-levels-of-un-switched-memory-b-cells-are-associated-with-better-outcome-in-patients-with-advanced-atherosclerotic-disease
#18
John A L Meeuwsen, Amerik van Duijvenvoorde, Aisha Gohar, Maria O Kozma, Sander M van de Weg, Crystel M Gijsberts, Saskia Haitjema, Harry Björkbacka, Gunilla N Fredrikson, Gert J de Borst, Hester M den Ruijter, Gerard Pasterkamp, Christoph J Binder, Imo E Hoefer, Saskia C A de Jager
BACKGROUND: Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease. METHODS AND RESULTS: This cohort study consists of 168 patients who were included in the Athero-Express biobank between 2009 and 2011...
September 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28880682/investigating-patterns-of-memory-impairment-in-ischemic-stroke-in-an-iranian-population
#19
Negar Karimian, Karim Asgari, Hamid Taher Neshat Doost, Hamid Reza Oreizi, Mohammad Reza Najafi
Up until the date of this research, studies have examined poststroke cognitive impairments in attention, memory, and executive functions. In this study, we investigated the occurrence of memory problems in various patterns of memory in ischemic stroke patients in an attempt to determine specific memory profiles of the patients. The goal was to determine the severity and patterns of memory impairments in ischemic stroke patients and to identify specific profiles of memory impairments in stroke patients, in order to help therapists to develop more appropriate memory rehabilitation programs for the patients...
September 7, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28842830/beneficial-effects-of-delayed-p7c3-a20-treatment-after-transient-mcao-in-rats
#20
Zachary B Loris, Justin R Hynton, Andrew A Pieper, W Dalton Dietrich
Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion after a 90-min middle cerebral artery occlusion (MCAO). In the present study, we investigated a more clinically relevant therapeutic window for P7C3-A20 treatment after ischemic stroke. MCAO rats were administered P7C3-A20 for 1 week, beginning immediately or at a delayed point, 6 h post-reperfusion...
August 25, 2017: Translational Stroke Research
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