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https://www.readbyqxmd.com/read/29222024/continuous-and-not-continuous-2-week-treadmill-training-enhances-the-performance-in-the-passive-avoidance-test-in-ischemic-gerbils
#1
Ana Paula Cassiano Silveira, Takae Tamy Kitabatake, Vivian Mozol Pantaleo, Hélio Zangrossi, Guilherme Bertolino, Elaine Caldeira de Oliveira Guirro, Hugo Celso Dutra de Souza, João Eduardo de Araujo
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29221967/improving-cognitive-function-in-patients-with-stroke-can-computerized-training-be-the-future
#2
Rosaria De Luca, Simona Leonardi, Letteria Spadaro, Margherita Russo, Bianca Aragona, Michele Torrisi, Maria Grazia Maggio, Alessia Bramanti, Antonino Naro, Maria Cristina De Cola, Rocco Salvatore Calabrò
BACKGROUND: Cognitive impairment after stroke is common and can cause disability with a high impact on quality of life and independence. Cognitive rehabilitation is a therapeutic approach designed to improve cognitive functioning after central nervous system's injuries. Computerized cognitive rehabilitation (CCR) uses multimedia and informatics resources to optimize cognitive compromised performances. The aim of this study is to evaluate the effects of pc cognitive training with Erica software in patients with stroke...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29218785/increased-affinity-of-endothelial-cells-to-niti-using-ultraviolet-irradiation-an-in-vitro-study
#3
Satoshi Tateshima, Naoki Kaneko, Masahiro Yamada, Gary Duckwiler, Fernando Vinuela, Takahiro Ogawa
Nickel - Titanium alloy (NiTi) is one of the most popular materials used endovascularly because of its shape memory and superelasticity. The NiTi device needs to be covered by endothelial cells after being placed in the blood vessel to reduce ischemic complications. The objective of this study was to examine the impact of ultraviolet (UV) irradiation on the biocompatibility of NiTi surfaces with endothelial cells. NiTi sheets were treated with UV irradiation for 48 hours and human aorta derived endothelial cells were used in this study...
December 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29215306/a-peptide-mimetic-of-tyrosine-phosphatase-step-as-a-potential-therapeutic-agent-for-treatment-of-cerebral-ischemic-stroke
#4
Ranjana Poddar, Sathyanarayanan Rajagopal, Lucas Winter, Andrea M Allan, Surojit Paul
Extensive research over the last two decades has advanced our understanding of the pathophysiology of ischemic stroke. However, current pharmacologic therapies are still limited to rapid reperfusion using thrombolytic agents, and neuroprotective approaches that can reduce the consequences of ischemic and reperfusion injury, are still not available. To bridge this gap, we have evaluated the long-term efficacy and therapeutic time window of a novel peptide-based neuroprotectant TAT-STEP, derived from the brain-enriched and neuron-specific tyrosine phosphatase STEP...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#5
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
December 4, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29196212/axl-activation-attenuates-neuroinflammation-by-inhibiting-the-tlr-traf-nf-%C3%AE%C2%BAb-pathway-after-mcao-in-rats
#6
Guangyong Wu, Devin W McBride, John H Zhang
BACKGROUND AND PURPOSE: Ischemic stroke activates Toll-like receptors (TLRs), triggering rapid inflammatory cytokine production. Axl signaling has multiple roles, including regulating cytokine secretion, clearing apoptotic cells, and maintaining cell survival, however, its role in inflammation after ischemic stroke has not been examined. We hypothesized that activation of Axl by recombinant Growth-arrest-specific protein 6 (rGas6) attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after middle cerebral artery occlusion (MCAO) in rats...
November 28, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29175152/transplantation-of-human-umbilical-cord-blood-mononuclear-cells-attenuated-ischemic-injury-in-mcao-rats-via-inhibition-of-nf-%C3%AE%C2%BAb-andnlrp3inflammasome
#7
Lu Liu, Juan Cen, Yong Man, Jianbin Li, Dahuan Zhang, Fei Wang, Jinhua Li, Ji Ma, Xiaoming Wang, Biansheng Ji
Accumulated evidences displayed that transplantation of stem cells may be a promising approach for the treatment of neurological disorders. However, the underlying mechanisms remain to be well elucidated. Moreover, some investigators can not reproduce similar results as the previous. The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29174035/effects-of-standard-ethanolic-extract-from-erythrina-velutina-in-acute-cerebral-ischemia-in-mice
#8
Francisca Taciana Rodrigues de Sousa, Caren Nádia Soares de Sousa, Naiara Coelho Ximenes, Anália Barbosa Almeida, Lucas Moraes Cabral, Cláudio Felipe Vasconcelos Patrocínio, Aline Holanda Silva, Luzia Kalyne Almeida Moreira Leal, José Eduardo Ribeiro Honório Júnior, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
The objective of this study was to verify a possible neuroprotective effect of the ethanolic extract of Erythrina velutina (EEEV). Male Swiss mice were submitted to transient cerebral ischemia by occlusion of both carotid arteries for 30 min and treated for 5 days with EEEV (200 or 400 mg/kg) or Memantine (MEM) 10 mg/kg, with initiation of treatment 2 or 24 h after Ischemia. On the 6th day after the induction of ischemia, the animals were submitted to evaluation of locomotor activity and memory and then sacrificed...
November 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29171488/-the-efficacy-of-recognan-in-the-early-stage-of-ischemic-stroke
#9
V V Mashin, L A Belova, E M Dudikov, T M Bergelson, V A Lankov, K A Zakuraeva
AIM: To assess the efficacy and safety of recognan in patients with acute ischemic stroke (IS). MATERIAL AND METHODS: Seventy-nine patients, aged from 30 to 80 years, were examined in the early stage of IS. All patients received recognan (citicoline) in dose of 1000 mg/daily during 15 days. The recovery of cognitive functions (MMSE), level of consciousness (Glasgow Coma Scale), severity of focal neurological deficit (NIHSS) and functional recovery (Rankin scale, Barthel index, Rivermead Mobility Index) were assessed...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29167635/physical-exercise-promotes-novel-object-recognition-memory-in-spontaneously-hypertensive-rats-after-ischemic-stroke-by-promoting-neural-plasticity-in-the-entorhinal-cortex
#10
Xiaona Pan, Ting Jiang, Liying Zhang, Haiqing Zheng, Jing Luo, Xiquan Hu
Cerebral ischemia leads to memory impairment, and several studies have indicated that physical exercise (PE) has memory-improving effects after ischemia. This study was designed to further explore the specific role of PE in novel object recognition (NOR) memory after stroke and the exact cortical regions in which memory is restored by PE. Spontaneously hypertensive rats (SHR) were subjected to transient middle cerebral artery occlusion (tMCAO) or sham surgery, followed by 26 days of PE starting on day 3 post-tMCAO...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29164308/endovascular-repair-of-40-visceral-artery-aneurysms-and-pseudoaneurysms-with-the-viabahn-stent-graft-technical-aspects-clinical-outcome-and-mid-term-patency
#11
Massimo Venturini, Paolo Marra, Michele Colombo, Marta Panzeri, Simone Gusmini, Claudio Sallemi, Marco Salvioni, Carolina Lanza, Giulia Agostini, Gianpaolo Balzano, Yamume Tshomba, Germano Melissano, Massimo Falconi, Roberto Chiesa, Francesco De Cobelli, Alessandro Del Maschio
PURPOSE: Endovascular repair of true visceral artery aneurysms (VAAs) and pseudoaneurysms (VAPAs) with stent-grafting (SG) can simultaneously allow aneurysm exclusion and vessel preservation, minimizing the risk of ischemic complications. Our aim was to report a single-center experience on SG of visceral aneurysms, focusing on technical aspects, clinical outcome and mid-term patency. MATERIALS AND METHODS: Consecutive patients affected by VAAs-VAPAs and submitted to endovascular treatment were retrospectively reviewed, and SG cases with the self-expandable peripheral Viabahn stent-graft were analyzed (2003-2017)...
November 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29159048/resting-state-connectivity-and-executive-functions-after-pediatric-arterial-ischemic-stroke
#12
Salome Kornfeld, Rui Yuan, Bharat B Biswal, Sebastian Grunt, Sandeep Kamal, Juan Antonio Delgado Rodríguez, Mária Regényi, Roland Wiest, Christian Weisstanner, Claus Kiefer, Maja Steinlin, Regula Everts
Background: The aim of this study was to compare the relationship between core executive functions and frontoparietal network connections at rest between children who had suffered an arterial ischemic stroke and typically developing peers. Methods: Children diagnosed with arterial ischemic stroke more than two years previously and typically developing controls were included. Executive function (EF) measures comprised inhibition (Go-NoGo task), fluency (category fluency task), processing speed (processing speed tasks), divided attention, working memory (letter-number sequencing), conceptual reasoning (matrices) and EF in everyday life (questionnaire)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158448/executive-function-declines-in-the-first-6-months-after-a-transient-ischemic-attack-or-transient-neurological-attack
#13
Frank G van Rooij, Nicole O Plaizier, Sarah E Vermeer, Bozena M Góraj, Peter J Koudstaal, Edo Richard, Frank-Erik de Leeuw, Roy P C Kessels, Ewoud J van Dijk
BACKGROUND AND PURPOSE: Although by definition transient, both transient ischemic attack (TIA) and transient neurological attack (TNA) are associated with cognitive impairment. Determinants and course of cognitive function afterward are, however, unclear. We prospectively determined cognitive performance after TIA and TNA in relation to clinical diagnosis and diffusion-weighted imaging (DWI) results. METHODS: TIA and TNA patients aged ≥45 years without prior stroke or dementia underwent comprehensive cognitive assessment and magnetic resonance imaging within 7 days after the qualifying event...
November 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29143805/mechanisms-of-acupuncture-therapy-in-ischemic-stroke-rehabilitation-a-literature-review-of-basic-studies
#14
REVIEW
Lina M Chavez, Shiang-Suo Huang, Iona MacDonald, Jaung-Geng Lin, Yu-Chen Lee, Yi-Hung Chen
Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29137683/tanshinone-i-alleviates-motor-and-cognitive-impairments-via-suppressing-oxidative-stress-in-the-neonatal-rats-after-hypoxic-ischemic-brain-damage
#15
Chunfang Dai, Yannan Liu, Zhifang Dong
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it is unclear whether administration of TsI has neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), and if so, the potential mechanisms also remain unclear. Here, we reported that treatment with TsI (5 mg/kg, i...
November 14, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29121965/chronic-cerebral-hypoperfusion-induces-post-stroke-dementia-following-acute-ischemic-stroke-in-rats
#16
Dong Bin Back, Kyoung Ja Kwon, Dong-Hee Choi, Chan Young Shin, Jongmin Lee, Seol-Heui Han, Hahn Young Kim
BACKGROUND: Post-stroke dementia (PSD) is one of the major consequences after stroke. Chronic cerebral hypoperfusion (CCH) can induce vascular cognitive impairment and potentiate amyloid pathology. We investigated how CCH contributes to the development of PSD after stroke in the context of neuroinflammation and amyloid pathology. METHODS: We designed a unique animal model for PSD. We performed middle cerebral artery occlusion (MCAO) surgery in rats mimicking acute territorial infarct, which was followed by bilateral common carotid artery occlusion (BCCAo) surgery mimicking CCH...
November 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29115588/limb-remote-ischemic-post%C3%A2-conditioning-reduces-injury-and-improves-long%C3%A2-term-behavioral-recovery-in-rats-following-subarachnoid-hemorrhage-possible-involvement-of-the-autophagic-process
#17
Xiang Hu, Tao Lv, Shao-Feng Yang, Xiao-Hua Zhang, Yi-Feng Miao
Hemorrhage‑related neurologic injury is a primary cause of disability and mortality following subarachnoid hemorrhage (SAH). The aim of the present study was to investigate the potential neuroprotective effect and the possible role of autophagy in limb remote ischemic post‑conditioning (RIPostC) using an endovascular puncture rat model of SAH. RIPostC was induced by three cycles of occlusion (10 min) and release (10 min) in the bilateral femoral artery using an aneurysm clip. Early RIPostC began immediately following SAH, delayed RIPostC began following a 30 min delay and the repeated RIPostC group underwent the protocol every day for 3 days...
October 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114096/fingolimod-protects-against-ischemic-white-matter-damage-by-modulating-microglia-toward-m2-polarization-via-stat3-pathway
#18
Chuan Qin, Wen-Hui Fan, Qian Liu, Ke Shang, Madhuvika Murugan, Long-Jun Wu, Wei Wang, Dai-Shi Tian
BACKGROUND AND PURPOSE: White matter (WM) ischemic injury, a major neuropathological feature of cerebral small vessel diseases, is an important cause of vascular cognitive impairment in later life. The pathogenesis of demyelination after WM ischemic damage are often accompanied by microglial activation. Fingolimod (FTY720) was approved for the treatment of multiple sclerosis for its immunosuppression property. In this study, we evaluated the neuroprotective potential of FTY720 in a WM ischemia model...
November 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29091896/effect-of-the-nadph-oxidase-inhibitor-apocynin-on-ischemia-reperfusion-hippocampus-injury-in-rat-brain
#19
Monika Kapoor, Neha Sharma, Rajat Sandhir, Bimla Nehru
Blockage along with sudden restoration of blood following ischemia, results in several cascading events, such as a massive ROS production which plays an important role in the pathophysiology of ischemia. NADPH oxidase complex in mitochondria complex is believed to be the major source for ROS production. The present study explores the therapeutic potential of apocynin, an NADPH oxidase inhibitor in attenuating the ROS production, and the resultant neuroinflammation and mitochondrial injury during cerebral ischemia in rats...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29078045/higher-aminopeptidase-activity-determined-by-electroosmotic-push-pull-perfusion-contributes-to-selective-vulnerability-of-the-hippocampal-ca1-region-to-oxygen-glucose-deprivation
#20
Yangguang Ou, Stephen G Weber
It has been known for over a century that the hippocampus, the center for learning and memory in the brain, is selectively vulnerable to ischemic damage, with the CA1 being more vulnerable than the CA3. It is also known that leucine enkephalin, or YGGFL, is neuroprotective. We hypothesized that the extracellular hydrolysis of YGGFL may be greater in the CA1 than the CA3, which would lead to the observed difference in susceptibility to ischemia. In rat organotypic hippocampal slice cultures, we estimated the Michaelis constant and the maximum velocity for membrane-bound aminopeptidase activity in the CA1 and CA3 regions...
November 16, 2017: ACS Chemical Neuroscience
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