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https://www.readbyqxmd.com/read/29725053/u-s-agro-climate-in-20-th-century-growing-degree-days-first-and-last-frost-growing-season-length-and-impacts-on-crop-yields
#1
Meetpal S Kukal, Suat Irmak
Significant air temperature changes have occurred globally during the 20th century, which are spatially variable to a considerable degree and these changes can have substantial implications in agroecosystem productivity. The agroclimate indicators that are responsible in these contexts are first fall frost (FFF), last spring frost (LSF), climatological growing season (CGS) length, and heat accumulation (growing degree days, GDD). We explore spatial and temporal trends associated with these indices across the continental U...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29673742/skin-models-and-their-impact-on-mean-glandular-dose-in-mammography
#2
Rodrigo Trevisan Massera, Alessandra Tomal
PURPOSE: To quantify the influence of different skin models on mammographic breast dosimetry, based on dosimetric protocols and recent breast skin thickness findings. METHODS: By using an adapted PENELOPE (v. 2014) + PenEasy (v. 2015) Monte Carlo (MC) code, simulations were performed in order to obtain the mean glandular dose (MGD), the normalized MGD by incident air Kerma (DgN), and the glandular depth dose (GDD(z)). The geometry was based on a cranio-caudal mammographic examination...
April 16, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29660288/atomic-orbital-implementation-of-extended-symmetry-adapted-perturbation-theory-xsapt-and-benchmark-calculations-for-large-supramolecular-complexes
#3
Ka Un Lao, John M Herbert
We report an implementation of extended symmetry-adapted perturbation theory (XSAPT) in the atomic orbital basis, extending this method to systems where the monomers are large. In our "XSAPT(KS)" approach, monomers are described using range-separated Kohn-Sham (KS) density functionals whose asymptotic behavior is set by tuning the range-separation parameter, ω, in a monomer-specific way. This is accomplished either by conventional ionization potential (IP)-based tuning, in which ω is adjusted to satisfy the condition εHOMO (ω) = -IP(ω), or else using a so-called "global density-dependent" (GDD) condition, in which ω is fixed based on the size of the exchange hole...
April 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29649939/participation-patterns-of-preschool-children-with-intellectual-developmental-disabilities
#4
Yafit Gilboa, Reut Fuchs
We aim to examine the pattern of participation of children with intellectual developmental disabilities (IDD) or global developmental delay (GDD) in comparison with typically developing preschoolers. In addition, to identify environmental and personal factors associated with their participation, 20 children with mild to moderate GDD or IDD, and 24 age- and gender-matched controls, aged 3 to 6 years, were assessed using the Assessment of Preschool Children's Participation and the Environmental Restriction Questionnaire...
April 1, 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29601363/outcomes-of-trabeculectomy-and-glaucoma-drainage-devices-for-elevated-intraocular-pressure-after-penetrating-keratoplasty
#5
Mehmet Yakin, Umit Eksioglu, Zuleyha Yalniz-Akkaya, Selma Uzman, Evin Singar-Ozdemir, Kemal Gultekin, Gulizar Demirok, Ilgaz Yalvac, Firdevs Ornek, Ayse Burcu
PURPOSE: To assess and compare the outcomes of trabeculectomy with and without antimetabolites (AMs) and glaucoma drainage devices (GDDs) in the management of elevated intraocular pressure (IOP) after penetrating keratoplasty (PK). METHODS: Data of 84 eyes of 81 patients who underwent trabeculectomy (12 eyes without an AM and 42 eyes with an AM) or GDD implantation (30 eyes) after PK were reviewed retrospectively. The main outcome measures were IOP control, corneal graft survival, and postoperative ocular complications...
March 28, 2018: Cornea
https://www.readbyqxmd.com/read/29593293/beclin1-restricts-rna-virus-infection-in-plants-through-suppression-and-degradation-of-the-viral-polymerase
#6
Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou, Aiming Wang
Autophagy emerges as an essential immunity defense against intracellular pathogens. Here we report that turnip mosaic virus (TuMV) infection activates autophagy in plants and that Beclin1 (ATG6), a core component of autophagy, inhibits virus replication. Beclin1 interacts with NIb, the RNA-dependent RNA polymerase (RdRp) of TuMV, via the highly conserved GDD motif and the interaction complex is targeted for autophagic degradation likely through the adaptor protein ATG8a. Beclin1-mediated NIb degradation is inhibited by autophagy inhibitors...
March 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/29557829/repair-of-exposed-ahmed-glaucoma-valve-tubes-long-term-outcomes
#7
Adi Einan-Lifshitz, Avner Belkin, David Mathew, Nir Sorkin, Clara C Chan, Yvonne M Buys, Graham E Trope, David S Rootman
PURPOSE: To assess the long-term outcomes of GDD exposure repair with corneal lamellar patch graft covered by a buccal mucous membrane graft sutured to surrounding conjunctiva. METHODS: In this retrospective longitudinal study, the charts of all patients who underwent buccal mucous membrane grafts combined with corneal lamellar patch grafts for exposed GDD tubes between the years 2006 to 2013 were reviewed. A minimum follow-up of 3 years was required for inclusion...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29521717/long-term-clinical-outcomes-of-pars-plana-versus-anterior-chamber-placement-of-glaucoma-implant-tubes
#8
Vivian L Qin, Mona Kaleem, Felipe F Conti, Edward J Rockwood, Annapurna Singh, Shalini Sood-Mendiratta, Jonathan E Sears, Fabiana Q Silva, Jonathan Eisengart, Rishi P Singh
PURPOSE: To compare long-term surgical outcomes and complications of pars plana (PP) tube implantation with conventional anterior chamber (AC) tube implantation. MATERIALS AND METHODS: Records of patients undergoing glaucoma tube implant surgery at a single institution between 2007 and 2015 were retrospectively reviewed. Eyes were matched for glaucoma diagnosis and patient age. Demographics, baseline characteristics, and treatment outcomes were recorded. Surgical success was defined as intraocular pressure (IOP) between 6 and 21 mm Hg, no subsequent glaucoma surgeries performed, and at least light perception vision...
May 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29518808/prosthodontic-treatment-of-a-patient-with-gnathodiaphyseal-dysplasia-30-year-follow-up
#9
Mohamed Moustafa Said, Takafumi Otomaru, Ayako Kanazaki, Haruka Fujita, Hisashi Taniguchi
This case history report describes the long-term prosthodontic treatment of a patient with gnathodiaphyseal dysplasia (GDD). The patient was initially diagnosed with osteomyelitis in the maxilla in 1986, followed by osteonecrosis spread throughout the mandible. GDD was genetically diagnosed in 2006. Despite the severe alveolar bone resorption, prosthodontic treatment improved the patient's satisfaction and ability to perform essential functions. Regular prosthesis adjustments and periodic follow-up should continue to avoid future complications...
March 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29505439/surgical-outcomes-of-a-new-low-cost-nonvalved-glaucoma-drainage-device-in-refractory-glaucoma-results-at-1-year
#10
Vanita Pathak Ray, Divya P Rao
PURPOSE: The purpose of this study was to report the early outcomes in terms of efficacy and safety of a new, indigenously manufactured, low-cost nonvalved drainage device [AADI (Aurolab Aqueous Drainage Implant)] in the management of refractory glaucoma in the Indian population. METHODS: Retrospective review of consecutive patients older than 12 years, who underwent glaucoma drainage device surgery (GDD) using AADI, by a single fellowship-trained surgeon, between January 2014 and December 2016, who had at least 3 months of documented post-op follow-up...
May 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29468208/novel-use-of-fibrin-sealant-for-scleral-suture-free-placement-of-a-glaucoma-drainage-device-in-advanced-scleral-thinning
#11
Justin D Harvey, Ronald L Gross, Brian D McMillan
Purpose: This reports a case using fibrin glue to secure a glaucoma drainage device plate to the sclera where there is a concern with the use of suture. Observations: A 13-year-old patient with congenital aniridia and associated glaucoma refractory to topical medications underwent implantation of a glaucoma drainage device (GDD) for improved intraocular pressure (IOP) control. The patient had substantial scleral thinning with staphyloma formation, potentially making the use of traditional suturing techniques problematic...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29423340/the-effects-of-glaucoma-drainage-devices-on-oxygen-tension-glycolytic-metabolites-and-metabolomics-profile-of-aqueous-humor-in-the-rabbit
#12
Blake K Williamson, Nathan M Hawkey, Diane A Blake, Joshua W Frenkel, Kevin P McDaniel, Justin K Davis, Celine Satija, Alex Beazer, Suraj Dhungana, James Carlson, Susan McRitchie, Ramesh S Ayyala
Purpose: Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods: Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealand white rabbits. Right eyes were used as a control. Oxygen tension was measured immediately before surgery and at 1 and 2 months postoperation. Aqueous humor was collected from the surgical and control eyes at 1, 2, and 5 months postoperation...
February 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29419708/intravenous-calcium-zinc-diethylene-triamine-penta-acetic-acid-in-patients-with-presumed-gadolinium-deposition-disease-a-preliminary-report-on-25-patients
#13
Richard C Semelka, Miguel Ramalho, Michael Jay, Lisa Hickey, Joseph Hickey
OBJECTIVES: The aim of this study was to report the use of intravenous calcium (Ca)-/zinc (Zn)-diethylene triamine penta-acetic acid (DTPA) for the treatment of 25 symptomatic patients diagnosed with gadolinium deposition disease (GDD). MATERIALS AND METHODS: Written informed consent was obtained. Twenty-five patients (18 women; mean age, 46.8 ± 15.3 years) with a diagnosis of GDD were included. All patients had received at least 1 administration of a gadolinium (Gd)-based contrast agent...
June 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29383822/comparison-of-diode-laser-trans-scleral-cyclophotocoagulation-versus-implantation-of-a-350-mm-2-baerveldt-glaucoma-drainage-device-for-the-treatment-of-glaucoma-in-dogs-a-retrospective-study-2010-2016
#14
Kathleen L Graham, Evelyn J S Hall, Charles Caraguel, Andrew White, Francis A Billson, F Mark Billson
OBJECTIVE: To compare outcomes following trans-scleral cyclophotocoagulation (TSCP) and 350-mm2 Baerveldt implantation in the treatment of canine refractory glaucoma. DESIGN: Retrospective case study. CASE SELECTION: Client owned dogs undergoing surgical treatment of glaucoma within a veterinary referral hospital. PROCEDURES: Eighty-six glaucoma surgeries were performed on 83 eyes (69 dogs) diagnosed with primary or secondary glaucoma...
January 31, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29239864/trabeculectomy-outcomes-after-glaucoma-drainage-device-surgery
#15
Reza Alizadeh, Handan Akil, James Tan, Simon K Law, Joseph Caprioli
PURPOSE: To evaluate outcomes of trabeculectomy with adjunctive mitomycin C in patients with uncontrolled intraocular pressure (IOP) after glaucoma drainage device implantation. MATERIALS AND METHODS: Consecutive patients who had undergone a trabeculectomy after GDD were reviewed. The primary outcome was surgical success with stratified IOP targets based on the following criteria: (A) IOP<18 mm Hg and IOP reduction of 20%; (B) IOP<15 mm Hg and IOP reduction of 25%; (C) IOP<12 mm Hg and IOP reduction of 30%...
February 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29209992/cost-effectiveness-of-karyotyping-chromosomal-microarray-analysis-and-targeted-next-generation-sequencing-of-patients-with-unexplained-global-developmental-delay-or-intellectual-disability
#16
Yonghong Li, Lori A Anderson, Edward I Ginns, James J Devlin
BACKGROUND: Genetic diagnosis of unexplained global developmental delay and intellectual disability (GDD/ID) often ends the diagnostic odyssey and can lead to changes in clinical management. OBJECTIVE: The objective of this study was to investigate the cost effectiveness of testing scenarios involving several methods used to diagnose GDD/ID: karyotyping, chromosomal microarray analysis (CMA), and targeted next-generation sequencing (NGS). METHODS: We used decision-tree models to estimate the number of genetic diagnoses, the cost from a payers' perspective in the USA, and the incremental cost per additional genetic diagnosis...
February 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29197142/new-insights-on-plant-phenological-response-to-temperature-revealed-from-long-term-widespread-observations-in-china
#17
Haicheng Zhang, Shuguang Liu, Pierre Regnier, Wenping Yuan
Constraints of temperature on spring plant phenology are closely related to plant growth, vegetation dynamics, and ecosystem carbon cycle. However, the effects of temperature on leaf onset, especially for winter chilling, are still not well understood. Using long-term, widespread in situ phenology observations collected over China for multiple plant species, this study analyzes the quantitative response of leaf onset to temperature, and compares empirical findings with existing theories and modeling approaches, as implemented in 18 phenology algorithms...
December 2, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29175271/gnathodiaphyseal-dysplasia-severe-atypical-presentation-with-novel-heterozygous-mutation-of-the-anoctamin-gene-ano5
#18
Ghada A Otaify, Michael P Whyte, Gary S Gottesman, William H McAlister, J Eric Gordon, Abby Hollander, Marisa V Andrews, Samir K El-Mofty, Wei-Shen Chen, Deborah V Veis, Marina Stolina, Albert S Woo, Panagiotis Katsonis, Olivier Lichtarge, Fan Zhang, Marwan Shinawi
Gnathodiaphyseal dysplasia (GDD; OMIM #166260) is an ultra-rare autosomal dominant disorder caused by heterozygous mutation in the anoctamin 5 (ANO5) gene and features fibro-osseous lesions of the jawbones, bone fragility with recurrent fractures, and bowing/sclerosis of tubular bones. The physiologic role of ANO5 is unknown. We report a 5-year-old boy with a seemingly atypical and especially severe presentation of GDD and unique ANO5 mutation. Severe osteopenia was associated with prenatal femoral fractures, recurrent postnatal fractures, and progressive bilateral enlargement of his maxilla and mandible beginning at ~2months-of-age that interfered with feeding and speech and required four debulking operations...
February 2018: Bone
https://www.readbyqxmd.com/read/29155662/global-disease-detection-achievements-in-applied-public-health-research-capacity-building-and-public-health-diplomacy-2001-2016
#19
Carol Y Rao, Grace W Goryoka, Olga L Henao, Kevin R Clarke, Stephanie J Salyer, Joel M Montgomery
The Centers for Disease Control and Prevention has established 10 Global Disease Detection (GDD) Program regional centers around the world that serve as centers of excellence for public health research on emerging and reemerging infectious diseases. The core activities of the GDD Program focus on applied public health research, surveillance, laboratory, public health informatics, and technical capacity building. During 2015-2016, program staff conducted 205 discrete projects on a range of topics, including acute respiratory illnesses, health systems strengthening, infectious diseases at the human-animal interface, and emerging infectious diseases...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29124309/gain-of-function-of-tmem16e-ano5-scrambling-activity-caused-by-a-mutation-associated-with-gnathodiaphyseal-dysplasia
#20
Eleonora Di Zanni, Antonella Gradogna, Joachim Scholz-Starke, Anna Boccaccio
Mutations in the human TMEM16E (ANO5) gene are associated both with the bone disease gnathodiaphyseal dysplasia (GDD; OMIM: 166260) and muscle dystrophies (OMIM: 611307, 613319). However, the physiological function of TMEM16E has remained unclear. We show here that human TMEM16E, when overexpressed in mammalian cell lines, displayed partial plasma membrane localization and gave rise to phospholipid scrambling (PLS) as well as non-selective ionic currents with slow time-dependent activation at highly depolarized membrane potentials...
November 9, 2017: Cellular and Molecular Life Sciences: CMLS
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