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Reut Avinun, Adam Nevo, Annchen R Knodt, Maxwell L Elliott, Spenser R Radtke, Bartholomew D Brigidi, Ahmad R Hariri
Sleep disturbances represent one risk factor for depression. Reward-related brain function, particularly the activity of the ventral striatum (VS), has been identified as a potential buffer against stress-related depression. We were therefore interested in testing whether reward-related VS activity would moderate the effect of sleep disturbances on depression in a large cohort of young adults. Data were available from 1129 university students (mean age 19.71 ± 1.25 years; 637 women) who completed a reward-related functional MRI task to assay VS activity and provided self-reports of sleep using the Pittsburgh Sleep Quality Index and symptoms of depression using a summation of the General Distress/Depression (GDD) and Anhedonic Depression (AD) subscales of the Mood and Anxiety Symptoms Questionnaire-short form...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Margaret Y Wang, Kishan Patel, Lauren S Blieden, Alice Z Chuang, Laura A Baker, Nicholas P Bell, Robert M Feldman
PURPOSE: Compare intraocular pressure (IOP) control and complication rates of a second glaucoma drainage device (GDD) to diode transscleral cyclophotocoagulation (TSCPC) following failure of an initial GDD. PATIENTS AND METHODS: Eyes with one GDD that required a second GDD or TSCPC for glaucoma control were included. Exclusion criteria were a cyclodestructive procedure prior to initial GDD, no light perception vision, or follow-up less than one year. Failure was defined as one or more of (1) reoperation for lowering IOP; (2) explantation of second GDD; (3) persistent hypotony; (4) use of oral carbonic anhydrase inhibitor for lowering IOP in the study eye; or (5) loss of light perception...
August 28, 2017: Journal of Glaucoma
Chantel C Barney, Raymond Tervo, George L Wilcox, Frank J Symons
Assessing tactile function among children with intellectual, motor, and communication impairments remains a clinical challenge. A case control design was used to test whether children with global developmental delays (GDD; n = 20) would be more/less reactive to a modified quantitative sensory test (mQST) compared to controls (n = 20). Reactivity was indexed by blinded behavioral coding across vocal, facial, and gross motor responses during the mQST. On average the children with GDD were significantly more reactive than controls to most tactile sensory modalities including light touch (p = ...
September 2017: American Journal on Intellectual and Developmental Disabilities
Yi Liu, Mei-Mei Cheng, Jian-Jian Dong, An Zhou
To study the intestinal absorptive characteristics of the ethanol extracts from Gandou decoction(GDD), everted intestinal sac models were used. The six representative ingredients (berberine hydrochloride, quercetin, kaempferide, rhein, chrysophanol, and aloe emodin) of GDD, were selected as the experimental targets to investigate the absorptive characteristics of various ingredients in different intestinal sections. The results showed that all six ingredients from GDD were detected in the intestinal sac, three active ingredients (berberine hydrochloride, quercetin, kaempferide) in high, medium and low doses had linear absorption properties in the small intestine segment, consistent with zero-order absorption rate; in addition, the absorption rate constant (Ka) of three components in jejunum and ileum were increased with the increase of the concentration of GDD (P<0...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Theresa M Crimmins, Michael A Crimmins, Katharine L Gerst, Alyssa H Rosemartin, Jake F Weltzin
PURPOSE: In support of science and society, the USA National Phenology Network (USA-NPN) maintains a rapidly growing, continental-scale, species-rich dataset of plant and animal phenology observations that with over 10 million records is the largest such database in the United States. The aim of this study was to explore the potential that exists in the broad and rich volunteer-collected dataset maintained by the USA-NPN for constructing models predicting the timing of phenological transition across species' ranges within the continental United States...
2017: PloS One
Simon S M Fung, Samir Jabbour, Mona Harissi-Dagher, Reginald R G Tan, Patrick Hamel, Kashif Baig, Asim Ali
PURPOSE: To report outcomes and complications of Boston type 1 keratoprosthesis (KPro) implantation in children. DESIGN: Retrospective, multicenter case series. PARTICIPANTS: All children 16 years of age or younger who underwent KPro surgery at 3 ophthalmology centers in Canada between January 2010 and November 2014. METHODS: Records of patients having undergone KPro implantation were reviewed. Data on preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes were collected and analyzed...
August 11, 2017: Ophthalmology
Jiyeon Park, Myoseon Jang, Zechen Yu
The impact of authentic mineral dust particles sourced from the Gobi Desert (GDD) on the kinetic uptake coefficient of SO2 was studied under varying environments (humidity, O3, and NOx) using both an indoor chamber and an outdoor chamber. There was a significant increase in the kinetic uptake coefficient of SO2 (γSO4(2-),light) for GDD particles under UV light compared to the value (γSO4(2-),dark) under dark conditions at various relative humidities (RH) ranging from 20% to 80%. In both the presence and the absence of O3 and NOx, γSO4(2-),light and γSO4(2-),dark greatly increased with increasing RH...
August 9, 2017: Environmental Science & Technology
Sarah F Ahmed, Mason Schmutz, Sameh Mosaed
PURPOSE: Tube exposure remains one of the most common complications after glaucoma drainage device (GDD) implantation, despite various types of patch grafts available today. We present a 4 patient case series following the effectivity of the keratolimbal allograft (KLAL) as a patch graft for cases of tube exposure. Given its inherent population of stem cells, our hypothesis was that this highly replicative, biological tissue would provide an adequate means of glaucoma tube coverage. The subset of patients chosen for the KLAL patch graft all had a history of abnormally scarred conjunctiva or thin sclera...
July 20, 2017: Journal of Glaucoma
Amy E Miller, Tammy L Wilson, Rosemary L Sherriff, James Walton
Regional warming has led to increased productivity near the boreal forest margin in Alaska. To date, the effects of warming on seedling recruitment have received little attention, in spite of forecasted forest expansion. Here, we used stand structure and environmental data from ninety-five white spruce (Picea glauca) plots sampled across a longitudinal gradient in southwest Alaska to explore factors influencing spruce establishment and recruitment near western treeline. We used total counts of live seedlings, saplings, and trees, representing five life stages, to evaluate whether geospatial, climate, and measured plot covariates predicted abundance, using current abundance distributions as a surrogate for climate conditions in the past...
July 16, 2017: Global Change Biology
Kateki Vinod, Steven J Gedde, William J Feuer, Joseph F Panarelli, Ta C Chang, Philip P Chen, Richard K Parrish
PURPOSE: The purpose of this study is to assess surgical practice patterns among the American Glaucoma Society (AGS) membership. METHODS: An anonymous online survey evaluating the use of glaucoma surgeries in various clinical settings was redistributed to AGS members. Survey responses were compared with prior results from 1996, 2002, and 2008 to determine shifts in surgical practice patterns. Questions were added to assess the preferred approach to primary incisional glaucoma surgery and phacoemulsification combined with glaucoma surgery...
August 2017: Journal of Glaucoma
Cem Ozgonul, Cagri G Besirli, Brenda L Bohnsack
PURPOSE: To evaluate efficacy of combined vitrectomy with posteriorly-placed glaucoma drainage device (GDD) in lowering intraocular pressure (IOP) in children. PATIENTS AND METHODS: Retrospective case review identified 20 children who underwent vitrectomy with posteriorly-placed GDD with minimal 6-months follow-up. First eye operated on was included. Success was defined as IOP 5-20 mmHg, no additional IOP-lowering surgery or visually-devastating complications. RESULTS: Patients with primary infantile-onset glaucoma (25%), traumatic glaucoma (15%), Peters anomaly (15%), microphthalmia (25%), glaucoma following cataract surgery (10%), microspherophakia (5%), and retinopathy of prematurity (5%) were included...
June 3, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Ariel Venezian, Evgenia Dor, Guy Achdari, Dina Plakhine, Evgeny Smirnov, Joseph Hershenhorn
Broomrapes (Phelipanche spp. and Orobanche spp.) are holoparasitic plants that cause tremendous losses of agricultural crops worldwide. Broomrape control is extremely difficult and only amino acid biosynthesis-inhibiting herbicides present an acceptable control level. It is expected that broomrape resistance to these herbicides is not long in coming. Our objective was to develop a broomrape control system in tomato (Solanum lycopersicum L.) based on the plant growth regulator maleic hydrazide (MH). Petri-dish and polyethylene-bag system experiments revealed that MH has a slight inhibitory effect on Phelipanche aegyptiaca seed germination but is a potent inhibitor of the first stages of parasitism, namely attachment and the tubercle stage...
2017: Frontiers in Plant Science
Young-Sook Kim, Myoung-Jae Lee
We consider the use of difference in differences (DD) to evaluate the effect of an activity assistance program on the health of severely disabled Koreans. There are, however, 2 problems in the data: the number of response categories for self-assessed health changed over the waves of the repeated cross-section survey and the "parallel untreated response path" assumption for DD is suspect. We show how to overcome these problems by renormalizing parameters and applying "generalized difference in differences (GDD)...
May 24, 2017: Health Economics
Kara Murias, Andrea Moir, Kenneth Alexis Myers, Irene Liu, Xing-Chang Wei
AIM: To summarize the reported rates of magnetic resonance imaging (MRI) abnormalities in children with isolated global developmental delay (GDD) or intellectual disability (ID). METHOD: A literature search was conducted using electronic databases for studies reporting the rate of MRI abnormalities in children with clinically diagnosed ID or GDD and no other neurological signs, symptoms, or previously determined aetiology. All investigations with participants from birth to 18years were considered...
April 27, 2017: Brain & Development
Paul Baciu, Stephen J Moster, Richard K Lee
PURPOSE: To describe a new approach for shortening silicone tubes of glaucoma drainage devices (GDDs). MATERIALS AND METHODS: A retrospective intervention case series describing 3 patients undergoing the same treatment at a single institutional center RESULTS:: Three patients underwent successful ab interno trimming of GDD silicone tubes without complication CONCLUSIONS:: This technique allows for rapid and successful shortening of GDD tubes via an ab interno approach avoiding risks of traditional glaucoma tube trimming approaches...
May 2017: Journal of Glaucoma
Edward Dervan, Edward Lee, Antonio Giubilato, Tina Khanam, Panayiotis Maghsoudlou, William H Morgan
IMPORTANCE: This study provides results of a treatment option for patients with failed primary glaucoma drainage device. BACKGROUND: The study aimed to describe and evaluate the long-term intraocular pressure control and complications of a new technique joining a second glaucoma drainage device directly to an existing glaucoma drainage device termed 'piggyback drainage'. DESIGN: This is a retrospective, interventional cohort study. PARTICIPANTS: Eighteen eyes of 17 patients who underwent piggyback drainage between 2004 and 2013 inclusive have been studied...
April 19, 2017: Clinical & Experimental Ophthalmology
Norma Kayrouz, Susan L Milne, Jenny L McDonald
AIM: To explore the association between social disadvantage and developmental diagnoses in pre-school children. METHODS: Between 2012 and 2015, 845 pre-school children were assessed by the Child Assessment Team at Campbelltown Hospital. A social worker interviewed 469 families and these children were eligible for inclusion in the study. Autism spectrum disorder (ASD) was confirmed in 290 children. Of those without ASD, 72 did not have global developmental delay (GDD) and were excluded from the study...
April 11, 2017: Journal of Paediatrics and Child Health
Itay Gdor, Tufan Ghosh, Oleg Lioubashevski, Sanford Ruhman
Impulsive Raman excitation in neat organic liquids far from resonance is followed using chirped broad-band supercontinuum probe pulses. Spectral modulations due to impulsively induced coherent vibrations vary in intensity 10-fold as a function of the probe's linear chirp. Simulations clarify why the vibrational signature is maximized for a group delay dispersion (GDD) in reduced units of νvib(-2) = 0.5 while a probe GDD of twice that quenches the same spectral modulations. Accordingly, recent claims that chirped white-light probe pulses provide equivalent information on material response to their compressed analogues must be taken with caution...
April 20, 2017: Journal of Physical Chemistry Letters
Zhaoxing Dai, Xiaobo Yu, Jianguo Sun, Xinghuai Sun
Purpose: To study the functional outcomes of filtration surgery by implanting improved glaucoma drainage devices (GDDs) comprising surface grooves and a composite coating of cyclosporine A (CsA) and PLGA in experimental rabbit eyes. Methods: Improved GDDs were designed and prepared by modifying normal GDD with surface grooves and a CsA-PLGA composite coating. Normal GDDs, grooved GDDs (G-GDDs), and G-GDDs with a CsA-PLGA composite coating (CsA@G-GDD) were implanted into 18 rabbit eyes (six eyes per group)...
March 1, 2017: Investigative Ophthalmology & Visual Science
Shawn M Iverson, Oriel Spierer, George C Papachristou, William J Feuer, Wei Shi, David S Greenfield, Terrence P O'Brien
PURPOSE: To compare corneal graft survival rates after penetrating keratoplasty (PK) and Descemet's stripping endothelial keratoplasty (DSEK) in patients with a glaucoma drainage device (GDD) or medically managed glaucoma. METHODS: A retrospective chart review was conducted on consecutive patients who underwent primary PK or primary DSEK. Inclusion criteria consisted of eyes with a diagnosis of glaucoma prior to corneal transplantation and a minimum of 6 months of follow-up...
March 16, 2017: International Ophthalmology
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