keyword
https://read.qxmd.com/read/32960627/-celiac-disease-causes-pathology-and-nutritional-assessment-of-gluten-free-diet-a-review
#21
REVIEW
Irene de la Calle, Gaspar Ros, Rocío Peñalver Miras, Gema Nieto
Introduction: celiac patients suffer deficiencies before and during their maintenance of a gluten-free diet. This is due to malabsorption, associated with the disease, and to non-enriched, mostly processed foods high in saturated fats and deficient in the minerals typically present in wheat. Objectives: the main objective of this review was to determine the molecular basis of celiac disease and the nutritional deficiencies that gluten-free diet entails, as well as an assessment of gluten-free diet and its nutritional deficiencies once the intestinal microvilli have been restored...
October 21, 2020: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/32384058/haematological-and-biochemical-reference-intervals-in-healthy-racing-and-retired-italian-greyhounds
#22
JOURNAL ARTICLE
Paola Scarpa, Beatrice Ruggerone, Sara Gironi, Tiziana Vitiello, Saverio Paltrinieri
In view of the enormous variability of dog breeds, breed-specific reference intervals (RIs) are recommended for use in veterinary clinical decision-making. The aim of this study was to determine whether RIs of the general canine population may be applied to the Italian Greyhound (Piccoli Levrieri Italiani or PLI), and to generate breed-specific RIs, where appropriate. Sixty-three privately owned clinically healthy fasted dogs were examined. Routine haematology and biochemistry were performed on 58 enrolled patients using the ADVIA 120 haematology analyzer and the Cobas Mira system, respectively...
May 8, 2020: Acta Veterinaria Hungarica
https://read.qxmd.com/read/32143096/as-v-sorption-from-aqueous-solutions-using-quaternized-algal-polyethyleneimine-composite-beads
#23
JOURNAL ARTICLE
Mohammed F Hamza, Siming Lu, Khalid A M Salih, Hamed Mira, Abdelghaffar S Dhmees, Toyohisa Fujita, Yuezhou Wei, Thierry Vincent, Eric Guibal
Composite beads (APEI*), obtained by the controlled interaction of algal biomass with PEI, followed by ionotropic gelation and crosslinking processes using CaCl2 /glutaraldehyde solution, constitute efficient supports for metal binding. The quaternization of algal/PEI beads (Q-APEI*) significantly increases the sorption properties of the composite beads (APEI*) for As(V). The materials are characterized by SEM/EDX, TGA, BET, elemental analysis, FTIR, XPS, and titration. The sorption of As(V) is studied in function of pH while sorption mechanism is discussed in function of metal speciation and surface characteristics of the sorbent...
February 20, 2020: Science of the Total Environment
https://read.qxmd.com/read/31553949/professional-female-athletes-are-at-a-heightened-risk-of-iron-deficient-erythropoiesis-compared-with-nonathletes
#24
JOURNAL ARTICLE
Nenad Ponorac, Mira Popović, Dea Karaba-Jakovljević, Zorislava Bajić, Aaron Scanlan, Emilija Stojanović, Dragan Radovanović
This study primarily aimed to quantify and compare iron status in professional female athletes and nonathletes. Furthermore, this study also aimed to identify differences in iron status according to sporting discipline and explore the relationship between ferritin concentration and weekly training volume in professional athletes. A total of 152 participants were included in this study, including 85 athletes who were members of senior teams (handball, n = 24; volleyball, n = 36; soccer, n = 19; and judo, n = 6) involved at the highest level of competition and 67 nonathletes...
January 1, 2020: International Journal of Sport Nutrition and Exercise Metabolism
https://read.qxmd.com/read/30718249/iron-chelator-deferasirox-reduces-candida-albicans-invasion-of-oral-epithelial-cells-and-infection-levels-in-murine-oropharyngeal-candidiasis
#25
JOURNAL ARTICLE
Sumant Puri, Rohitashw Kumar, Isolde G Rojas, Ornella Salvatori, Mira Edgerton
Candida albicans , the causative agent of mucosal infections including oropharyngeal candidiasis (OPC) as well as bloodstream infections is becoming increasingly resistant to existing treatment options. In the absence of novel drug candidates, drug repurposing aimed at using existing drugs to treat off label diseases is a promising strategy. C. albicans requires environmental iron for survival and virulence while host nutritional immunity deploys iron-binding proteins to sequester iron and reduce fungal growth...
February 4, 2019: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/30704361/toxicity-evaluation-of-monodisperse-pegylated-magnetic-nanoparticles-for-nanomedicine
#26
JOURNAL ARTICLE
Vitalii Patsula, Jana Tulinska, Štěpánka Trachtová, Miroslava Kuricova, Aurelia Liskova, Alena Španová, Fedor Ciampor, Ivo Vavra, Bohuslav Rittich, Monika Ursinyova, Mária Dusinska, Silvia Ilavska, Mira Horvathova, Vlasta Masanova, Iveta Uhnakova, Daniel Horák
Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic Fe3 O4 nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible in water and cell culture medium, they were modified with phosphonic acid- (PA) and hydroxamic acid (HA)-terminated poly(ethylene glycol) yielding PA-PEG@Fe3 O4 and HA-PEG@Fe3 O4 nanoparticles; conventional γ-Fe2 O3 particles were prepared as a control...
February 1, 2019: Nanotoxicology
https://read.qxmd.com/read/30489504/persistent-inflammation-and-anemia-among-critically-ill-septic-patients
#27
JOURNAL ARTICLE
Tyler J Loftus, Juan C Mira, Julie A Stortz, Tezcan Ozrazgat-Baslanti, Gabriella L Ghita, Zhongkai Wang, Babette A Brumback, Ricardo F Ungaro, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A Moore, Lyle L Moldawer, Scott C Brakenridge, Philip A Efron, Alicia M Mohr
BACKGROUND: Associations among inflammatory cytokines, erythropoietin (EPO), and anemia in critically ill septic patients remain unclear. This study tested the hypothesis that elevated inflammatory cytokines and decreased EPO would be associated with iron-restricted anemia while accounting for operative blood loss, phlebotomy blood loss, and red blood cell (RBC) transfusion volume. METHODS: Prospective observational cohort study of 42 critically ill septic patients was conducted...
February 2019: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/29793376/longitudinal-assessments-in-continuing-specialty-certification-and-lifelong-learning
#28
JOURNAL ARTICLE
David W Price, David B Swanson, Mira B Irons, Richard E Hawkins
Longitudinal assessment (LA) involves the regular, spaced delivery of a limited number of questions on practice relevant content on a computer or mobile internet platform. Depending on the platform, participants may indicate relevance of the content to their practice and confidence in their answer prior to receiving immediate feedback (including critiques) on each question. Individual dashboards may be included to assist participants in tracking progress and identifying areas of strength and weaknesss across a content blueprint...
May 24, 2018: Medical Teacher
https://read.qxmd.com/read/29768025/the-postinjury-inflammatory-state-and-the-bone-marrow-response-to-anemia
#29
JOURNAL ARTICLE
Tyler J Loftus, Juan C Mira, Elizabeth S Miller, Kolenkode B Kannan, Jessica M Plazas, Daniel Delitto, Julie A Stortz, Jennifer E Hagen, Hari K Parvataneni, Kalia K Sadasivan, Scott C Brakenridge, Frederick A Moore, Lyle L Moldawer, Philip A Efron, Alicia M Mohr
RATIONALE: The pathophysiology of persistent injury-associated anemia is incompletely understood, and human data are sparse. OBJECTIVES: To characterize persistent injury-associated anemia among critically ill trauma patients with the hypothesis that severe trauma would be associated with neuroendocrine activation, erythropoietin dysfunction, iron dysregulation, and decreased erythropoiesis. METHODS: A translational prospective observational cohort study comparing severely injured, blunt trauma patients who had operative fixation of a hip or femur fracture (n = 17) with elective hip repair patients (n = 22)...
September 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/29686781/salivary-metals-age-and-gender-correlate-with-cultivable-oral-candida-carriage-levels
#30
JOURNAL ARTICLE
Hannah L Norris, Justin Friedman, Ziqiang Chen, Sumant Puri, Gregory Wilding, Mira Edgerton
Background : Little is known about the normal range of metal levels in unstimulated saliva, nor whether these might impact Candida carriage in healthy individuals. Both are important in determining which populations are at risk for candidiasis, as the availability of metal ions can influence the growth and pathogenesis of Candida albicans . Objective : We quantified salivary metals of healthy individuals to determine the correlation with C. albicans oral colonization. Design : Unstimulated whole saliva was collected from healthy adults and plated to determine fungal carriage, and metal content was measured using ICP-mass spectrometry (ICP-MS)...
2018: Journal of Oral Microbiology
https://read.qxmd.com/read/29466280/persistent-injury-associated-anemia-and-aging-novel-insights
#31
JOURNAL ARTICLE
Tyler J Loftus, Kolenkode B Kannan, Christy S Carter, Jessica M Plazas, Juan C Mira, Scott C Brakenridge, Christiaan Leeuwenburgh, Philip A Efron, Alicia M Mohr
BACKGROUND: Hypercatecholaminemia and bone marrow dysfunction have been implicated in the pathophysiology of persistent injury-associated anemia. The elderly may be more vulnerable to bone marrow dysfunction due to high basal and peak catecholamine levels and impaired hematopoietic progenitor growth. We hypothesized that aging would adversely affect persistent injury-associated anemia. METHODS: Male Sprague-Dawley rats aged 8 to 9 weeks and F344-BN rats aged 25 months were randomized to naive controls, lung contusion plus hemorrhagic shock (LCHS), and LCHS plus daily chronic restraint stress (LCHS/CS)...
March 2018: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/29335019/patient-blood-management-programs-how-to-spread-the-word
#32
COMMENT
Shoshana Revel-Vilk, Mira Naamad
Red blood cell (RBC) transfusions save lives and improve health; however, unnecessary transfusion practice exposes patients to immediate and long-term negative consequences. Indirect consequences of unnecessary transfusions are the reduced availability of RBC units for patients who are in need. Accumulating evidence shows that restricting RBC transfusions improves outcomes and current guidelines suggest limiting RBC transfusion to the minimum number of units required to relieve symptoms of anemia or to return the patient to a safe hemoglobin range (7-8 g/dl in stable, non-cardiac inpatients)...
January 15, 2018: Israel Journal of Health Policy Research
https://read.qxmd.com/read/28813428/soil-features-in-rookeries-of-antarctic-penguins-reveal-sea-to-land-biotransport-of-chemical-pollutants
#33
JOURNAL ARTICLE
Anna C Santamans, Rafael Boluda, Antonio Picazo, Carlos Gil, Joaquín Ramos-Miras, Pablo Tejedo, Luis R Pertierra, Javier Benayas, Antonio Camacho
The main soil physical-chemical features, the concentrations of a set of pollutants, and the soil microbiota linked to penguin rookeries have been studied in 10 selected sites located at the South Shetland Islands and the Antarctic Peninsula (Maritime Antarctica). This study aims to test the hypothesis that biotransport by penguins increases the concentration of pollutants, especially heavy metals, in Antarctic soils, and alters its microbiota. Our results show that penguins do transport certain chemical elements and thus cause accumulation in land areas through their excreta...
2017: PloS One
https://read.qxmd.com/read/28719049/pulmonary-vein-stenosis-in-patients-with-smith-lemli-opitz-syndrome
#34
JOURNAL ARTICLE
Aaron R Prosnitz, Jane Leopold, Mira Irons, Kathy Jenkins, Amy E Roberts
OBJECTIVE: To describe a group of children with co-incident pulmonary vein stenosis and Smith-Lemli-Opitz syndrome and to generate hypotheses as to the shared pathogenesis of these disorders. DESIGN: Retrospective case series. PATIENTS: Five subjects in a pulmonary vein stenosis cohort of 170 subjects were diagnosed with Smith-Lemli-Opitz syndrome soon after birth. RESULTS: All five cases were diagnosed with Smith-Lemli-Opitz syndrome within 6 weeks of life, with no family history of either disorder...
July 2017: Congenital Heart Disease
https://read.qxmd.com/read/28535237/effect-of-intravenous-ferric-carboxymaltose-on-hemoglobin-response-among-patients-with-acute-isovolemic-anemia-following-gastrectomy-the-fairy-randomized-clinical-trial
#35
RANDOMIZED CONTROLLED TRIAL
Young-Woo Kim, Jae-Moon Bae, Young-Kyu Park, Han-Kwang Yang, Wansik Yu, Jeong Hwan Yook, Sung Hoon Noh, Mira Han, Keun Won Ryu, Tae Sung Sohn, Hyuk-Joon Lee, Oh Kyoung Kwon, Seung Yeob Ryu, Jun-Ho Lee, Sung Kim, Hong Man Yoon, Bang Wool Eom, Min-Gew Choi, Beom Su Kim, Oh Jeong, Yun-Suhk Suh, Moon-Won Yoo, In Seob Lee, Mi Ran Jung, Ji Yeong An, Hyoung-Il Kim, Youngsook Kim, Hannah Yang, Byung-Ho Nam
IMPORTANCE: Acute isovolemic anemia occurs when blood loss is replaced with fluid. It is often observed after surgery and negatively influences short-term and long-term outcomes. OBJECTIVE: To evaluate the efficacy and safety of ferric carboxymaltose to treat acute isovolemic anemia following gastrectomy. DESIGN, SETTING, AND PARTICIPANTS: The FAIRY trial was a patient-blinded, randomized, phase 3, placebo-controlled, 12-week study conducted between February 4, 2013, and December 15, 2015, in 7 centers across the Republic of Korea...
May 23, 2017: JAMA
https://read.qxmd.com/read/28237752/novel-magnetically-separable-silver-iron-oxide-nanoparticles-decorated-graphitic-carbon-nitride-nano-sheets-a-multifunctional-photocatalyst-via-one-step-hydrothermal-process
#36
JOURNAL ARTICLE
Bishweshwar Pant, Mira Park, Joong Hee Lee, Hak-Yong Kim, Soo-Jin Park
Development of photocatalytic materials with magnetic and antibacterial properties is highly desirable in wastewater treatment. In this study, a novel magnetically separable silver-iron oxide nanoparticles (Ag-Fe3O4 NPs) decorated graphitic carbon nitride (g-C3N4) nanocomposite via hydrothermal treatment has been presented for the multifaceted applications. The physiochemical properties of the as-synthesized ternary nanocomposite were characterized by the field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and photoluminescence (PL) studies...
June 15, 2017: Journal of Colloid and Interface Science
https://read.qxmd.com/read/28060487/how-does-the-amount-and-composition-of-pm-deposited-on-platanus-acerifolia-leaves-change-across-different-cities-in-europe
#37
JOURNAL ARTICLE
Chiara Baldacchini, Ana Castanheiro, Nairuhi Maghakyan, Gregorio Sgrigna, Jolien Verhelst, Rocío Alonso, Jorge H Amorim, Patrick Bellan, Danijela Đunisijević Bojović, Jürgen Breuste, Oliver Bühler, Ilie C Cântar, Paloma Cariñanos, Giulia Carriero, Galina Churkina, Lucian Dinca, Raffaela Esposito, Stanisław W Gawroński, Maren Kern, Didier Le Thiec, Marco Moretti, Tine Ningal, Eleni C Rantzoudi, Iztok Sinjur, Biljana Stojanova, Mira Aničić Urošević, Violeta Velikova, Ivana Živojinović, Lilit Sahakyan, Carlo Calfapietra, Roeland Samson
Particulate matter (PM) deposited on Platanus acerifolia tree leaves has been sampled in the urban areas of 28 European cities, over 20 countries, with the aim of testing leaf deposited particles as indicator of atmospheric PM concentration and composition. Leaves have been collected close to streets characterized by heavy traffic and within urban parks. Leaf surface density, dimensions, and elemental composition of leaf deposited particles have been compared with leaf magnetic content, and discussed in connection with air quality data...
February 7, 2017: Environmental Science & Technology
https://read.qxmd.com/read/27563589/evaluation-of-impact-of-teaching-clinical-pharmacology-and-rational-therapeutics-to-medical-undergraduates-and-interns
#38
JOURNAL ARTICLE
Mira K Desai, Jigar R Panchal, Samdih Shah, Geetha Iyer
OBJECTIVES: To find out the impact of teaching clinical pharmacology and rational therapeutics (CPT) to medical undergraduates (UGs) and interns. MATERIALS AND METHODS: This cross-sectional, prospective study was conducted on three UGs batches and interns using two pretested validated structured questionnaires, modified from the work of Tobaiqy et al. The study was approved by the Institutional Ethics Committee. ANOVA and Chi-square test were used for statistical analysis...
July 2016: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/27409249/from-peptide-aptamers-to-inhibitors-of-fur-bacterial-transcriptional-regulator-of-iron-homeostasis-and-virulence
#39
JOURNAL ARTICLE
Sophie Mathieu, Cheickna Cissé, Sylvia Vitale, Aynur Ahmadova, Mélissa Degardin, Julien Pérard, Pierre Colas, Roger Miras, Didier Boturyn, Jacques Covès, Serge Crouzy, Isabelle Michaud-Soret
FUR (Ferric Uptake Regulator) protein is a global transcriptional regulator that senses iron status and controls the expression of genes involved in iron homeostasis, virulence, and oxidative stress. Ubiquitous in Gram-negative bacteria and absent in eukaryotes, FUR is an attractive antivirulence target since the inactivation of the fur gene in various pathogens attenuates their virulence. The characterization of 13-aa-long anti-FUR linear peptides derived from the variable part of the anti-FUR peptide aptamers, that were previously shown to decrease pathogenic E...
September 16, 2016: ACS Chemical Biology
https://read.qxmd.com/read/27355778/the-abms-moc-part-iii-examination-value-concerns-and-alternative-formats
#40
Richard E Hawkins, Mira Bjelotomich Irons, Catherine M Welcher, Mellie Villahermosa Pouwels, Eric S Holmboe, Earl J Reisdorff, Joshua M Cohen, Susan Dentzer, David G Nichols, Cynthia A Lien, Thomas D Horn, R Barrett Noone, Rebecca S Lipner, Kevin W Eva, John J Norcini, Lois Margaret Nora, Jeffrey P Gold
This article describes the presentations and discussions at a conference co-convened by the Council on Medical Education of the American Medical Association (AMA) and by the American Board of Medical Specialties (ABMS). The conference focused on the ABMS Maintenance of Certification (MOC) Part III Examination. This article, reflecting the conference agenda, covers the value of and evidence supporting the examination, as well as concerns about the cost of the examination, and-given the current format-its relevance...
November 2016: Academic Medicine
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