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https://www.readbyqxmd.com/read/27563589/evaluation-of-impact-of-teaching-clinical-pharmacology-and-rational-therapeutics-to-medical-undergraduates-and-interns
#1
Mira K Desai, Jigar R Panchal, Samdih Shah, Geetha Iyer
OBJECTIVES: To find out the impact of teaching clinical pharmacology and rational therapeutics (CPT) to medical undergraduates (UGs) and interns. MATERIALS AND METHODS: This cross-sectional, prospective study was conducted on three UGs batches and interns using two pretested validated structured questionnaires, modified from the work of Tobaiqy et al. The study was approved by the Institutional Ethics Committee. ANOVA and Chi-square test were used for statistical analysis...
July 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27409249/from-peptide-aptamers-to-inhibitors-of-fur-bacterial-transcriptional-regulator-of-iron-homeostasis-and-virulence
#2
Sophie Mathieu, Cheickna Cissé, Sylvia Vitale, Aynur Ahmadova, Mélissa Degardin, Julien Pérard, Pierre Colas, Roger Miras, Didier Boturyn, Jacques Covès, Serge Crouzy, Isabelle Michaud-Soret
FUR (Ferric Uptake Regulator) protein is a global transcriptional regulator that senses iron status and controls the expression of genes involved in iron homeostasis, virulence, and oxidative stress. Ubiquitous in Gram-negative bacteria and absent in eukaryotes, FUR is an attractive antivirulence target since the inactivation of the fur gene in various pathogens attenuates their virulence. The characterization of 13-aa-long anti-FUR linear peptides derived from the variable part of the anti-FUR peptide aptamers, that were previously shown to decrease pathogenic E...
September 16, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27355778/the-abms-moc-part-iii-examination-value-concerns-and-alternative-formats
#3
Richard E Hawkins, Mira Bjelotomich Irons, Catherine M Welcher, Mellie Villahermosa Pouwels, Eric S Holmboe, Earl J Reisdorff, Joshua M Cohen, Susan Dentzer, David G Nichols, Cynthia A Lien, Thomas D Horn, R Barrett Noone, Rebecca S Lipner, Kevin W Eva, John J Norcini, Lois Margaret Nora, Jeffrey P Gold
This article describes the presentations and discussions at a conference co-convened by the Council on Medical Education of the American Medical Association (AMA) and by the American Board of Medical Specialties (ABMS). The conference focused on the ABMS Maintenance of Certification (MOC) Part III Examination. This article, reflecting the conference agenda, covers the value of and evidence supporting the examination, as well as concerns about the cost of the examination, and-given the current format-its relevance...
June 28, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27172188/fungal-innate-immunity-induced-by-bacterial-microbe-associated-molecular-patterns-mamps
#4
Simon Ipcho, Thomas Sundelin, Gitte Erbs, H Corby Kistler, Mari-Anne Newman, Stefan Olsson
Plants and animals detect bacterial presence through Microbe-Associated Molecular Patterns (MAMPs) which induce an innate immune response. The field of fungal-bacterial interaction at the molecular level is still in its infancy and little is known about MAMPs and their detection by fungi. Exposing Fusarium graminearum to bacterial MAMPs led to increased fungal membrane hyperpolarization, a putative defense response, and a range of transcriptional responses. The fungus reacted with a different transcript profile to each of the three tested MAMPs, although a core set of genes related to energy generation, transport, amino acid production, secondary metabolism, and especially iron uptake were detected for all three...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27106358/functionalized-porous-silica-maghemite-core-shell-nanoparticles-for-applications-in-medicine-design-synthesis-and-immunotoxicity
#5
Beata A Zasonska, Aurelia Líškova, Miroslava Kuricova, Jana Tulinska, Ognen Pop-Georgievski, Fedor Čiampor, Ivo Vavra, Maria Dušinska, Silvia Ilavska, Mira Horvathova, Daniel Horák
AIM: To determine cytotoxicity and effect of silica-coated magnetic nanoparticles (MNPs) on immune response, in particular lymphocyte proliferative activity, phagocytic activity, and leukocyte respiratory burst and in vitro production of interleukin-6 (IL-6) and 8 (IL-8), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and granulocyte macrophage colony stimulating factor (GM-CSF). METHODS: Maghemite was prepared by coprecipitation of iron salts with ammonia, oxidation with NaOCl and modified by tetramethyl orthosilicate and aminosilanes...
April 23, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/26886069/quaternary-structure-of-fur-proteins-a-new-subfamily-of-tetrameric-proteins
#6
Julien Pérard, Jacques Covès, Mathieu Castellan, Charles Solard, Myriam Savard, Roger Miras, Sandra Galop, Luca Signor, Serge Crouzy, Isabelle Michaud-Soret, Eve de Rosny
The ferric uptake regulator (Fur) belongs to the family of the DNA-binding metal-responsive transcriptional regulators. Fur is a global regulator found in all proteobacteria. It controls the transcription of a wide variety of genes involved in iron metabolism but also in oxidative stress or virulence factor synthesis. When bound to ferrous iron, Fur can bind to specific DNA sequences, called Fur boxes. This binding triggers the repression or the activation of gene expression, depending on the regulated genes...
March 15, 2016: Biochemistry
https://www.readbyqxmd.com/read/26445083/expanding-educators-contributions-to-continuous-quality-improvement-of-american-board-of-medical-specialties-maintenance-of-certification
#7
Lois Margaret Nora, Mellie Villahermosa Pouwels, Mira Irons
The American Board of Medical Specialties board certification has transformed into a career-long process of learning, assessment, and performance improvement through its Program for Maintenance of Certification (MOC). Medical educators across many medical professional organizations, specialty societies, and other institutions have played important roles in shaping MOC and tailoring its overarching framework to the needs of different specialties. This Commentary addresses potential barriers to engagement in work related to MOC for medical school (MS) and academic health center (AHC) educators and identifies reasons for, and ways to accomplish, greater involvement in this work...
January 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/26272225/the-human-oral-metaproteome-reveals-potential-biomarkers-for-caries-disease
#8
Pedro Belda-Ferre, James Williamson, Áurea Simón-Soro, Alejandro Artacho, Ole N Jensen, Alex Mira
Tooth decay is considered the most prevalent human disease worldwide. We present the first metaproteomic study of the oral biofilm, using different mass spectrometry approaches that have allowed us to quantify individual peptides in healthy and caries-bearing individuals. A total of 7771 bacterial and 853 human proteins were identified in 17 individuals, which provide the first available protein repertoire of human dental plaque. Actinomyces and Coryneybacterium represent a large proportion of the protein activity followed by Rothia and Streptococcus...
October 2015: Proteomics
https://www.readbyqxmd.com/read/25930980/a-study-on-the-effect-of-cimetidine-and-l-carnitine-on-myoglobinuric-acute-kidney-injury-in-male-rats
#9
Suzanne Estaphan, Hassan Eissa, Samah Elattar, Laila Rashed, Mira Farouk
Myoglobinuric acute renal failure is the most important life threatening complication of rhabdomyolysis. Iron, free radicals, nitric oxide and cytochrome p450 are involved in the pathogenesis of mARF. The aim of this study is to compare the effect of cimetidine, l-carnitine and both agents together on mARF in rats. Forty rats were divided into 5 groups; group I: control rats, group II: myoglobinuric ARF rats, group III: mARF rats received l-carnitine (200mg/kg, i.p.), group IV: mARF rats received cimetidine (150mg/kg i...
July 2015: Injury
https://www.readbyqxmd.com/read/25853251/the-palaeoenvironmental-impact-of-prehistoric-settlement-and-proto-historic-urbanism-tracing-the-emergence-of-the-oppidum-of-corent-auvergne-france
#10
Paul M Ledger, Yannick Miras, Matthieu Poux, Pierre Yves Milcent
Early human societies and their interactions with the natural world have been extensively explored in palaeoenvironmental studies across Central and Western Europe. Yet, despite an extensive body of scholarship, there is little consideration of the environmental impacts of proto-historic urbanisation. Typically palaeoenvironmental studies of Bronze and Iron Age societies discuss human impact in terms of woodland clearance, landscape openness and evidence for agriculture. Although these features are clearly key indicators of human settlement, and characterise Neolithic and early to Middle Bronze Age impacts at Corent, they do not appear to represent defining features of a protohistoric urban environment...
2015: PloS One
https://www.readbyqxmd.com/read/25564894/maintenance-of-certification-2-0-strong-start-continued-evolution
#11
Mira B Irons, Lois M Nora
New England Journal of Medicine, Volume 372, Issue 2, Page 104-106, January 2015.
January 8, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25463232/electricity-generation-from-tetrathionate-in-microbial-fuel-cells-by-acidophiles
#12
Mira L K Sulonen, Marika E Kokko, Aino-Maija Lakaniemi, Jaakko A Puhakka
Inorganic sulfur compounds, such as tetrathionate, are often present in mining process and waste waters. The biodegradation of tetrathionate was studied under acidic conditions in aerobic batch cultivations and in anaerobic anodes of two-chamber flow-through microbial fuel cells (MFCs). All four cultures originating from biohydrometallurgical process waters from multimetal ore heap bioleaching oxidized tetrathionate aerobically at pH below 3 with sulfate as the main soluble metabolite. In addition, all cultures generated electricity from tetrathionate in MFCs at pH below 2...
March 2, 2015: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/25048341/significant-association-of-deficiencies-of-hemoglobin-iron-vitamin-b12-and-folic-acid-and-high-homocysteine-level-with-recurrent-aphthous-stomatitis
#13
Andy Sun, Hsin-Ming Chen, Shih-Jung Cheng, Yi-Ping Wang, Julia Yu-Fong Chang, Yang-Che Wu, Chun-Pin Chiang
BACKGROUND: A portion of patients with recurrent aphthous stomatitis (RAS) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high blood homocysteine level with RAS. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 273 RAS patients were measured and compared with the corresponding levels in 273 age- and sex-matched healthy control subjects...
April 2015: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/24889932/iron-responsive-chromatin-remodelling-and-mapk-signalling-enhance-adhesion-in-candida-albicans
#14
Sumant Puri, William K M Lai, Jason M Rizzo, Michael J Buck, Mira Edgerton
Recent cumulative data show that various transcription factors are recruited to the chromatin in an iron-responsive manner to affect diverse cellular functions in the pathogenic fungus Candida albicans. Here we identified groups of iron-responsive genes in C. albicans by chromatin remodelling analysis at gene promoters, using micrococcal nuclease (MNase) digestion followed by deep sequencing. Chromatin in the promoter regions of iron uptake and utilization genes showed repressed and active configuration, respectively, under iron-replete conditions...
July 2014: Molecular Microbiology
https://www.readbyqxmd.com/read/24811917/copy-number-variation-plays-an-important-role-in-clinical-epilepsy
#15
Heather Olson, Yiping Shen, Jennifer Avallone, Beth R Sheidley, Rebecca Pinsky, Ann M Bergin, Gerard T Berry, Frank H Duffy, Yaman Eksioglu, David J Harris, Fuki M Hisama, Eugenia Ho, Mira Irons, Christina M Jacobsen, Philip James, Sanjeev Kothare, Omar Khwaja, Jonathan Lipton, Tobias Loddenkemper, Jennifer Markowitz, Kiran Maski, J Thomas Megerian, Edward Neilan, Peter C Raffalli, Michael Robbins, Amy Roberts, Eugene Roe, Caitlin Rollins, Mustafa Sahin, Dean Sarco, Alison Schonwald, Sharon E Smith, Janet Soul, Joan M Stoler, Masanori Takeoka, Wen-Han Tan, Alcy R Torres, Peter Tsai, David K Urion, Laura Weissman, Robert Wolff, Bai-Lin Wu, David T Miller, Annapurna Poduri
OBJECTIVE: To evaluate the role of copy number abnormalities detectable using chromosomal microarray (CMA) testing in patients with epilepsy at a tertiary care center. METHODS: We identified patients with International Classification of Diseases, ninth revision (ICD-9) codes for epilepsy or seizures and clinical CMA testing performed between October 2006 and February 2011 at Boston Children's Hospital. We reviewed medical records and included patients who met criteria for epilepsy...
June 2014: Annals of Neurology
https://www.readbyqxmd.com/read/24663495/automation-of-o-dianisidine-assay-for-ceruloplasmin-activity-analyses-usefulness-of-investigation-in-wilson-s-disease-and-in-hepatic-encephalopathy
#16
Mariacristina Siotto, Patrizio Pasqualetti, Massimo Marano, Rosanna Squitti
Ceruloplasmin (Cp) is a serum ferroxidase that plays an essential role in iron metabolism. It is routinely tested by immunoturbidimetric assays that quantify the concentration of the protein both in its active and inactive forms. Cp activity is generally analyzed manually; the process is time-consuming, has a limited repeatability, and is not suitable for a clinical setting. To overcome these inconveniences, we have set the automation of the o-dianisidine Cp activity assay on a Cobas Mira Plus apparatus. The automation was rapid and repeatable, and the data were provided in terms of IU/L...
October 2014: Journal of Neural Transmission
https://www.readbyqxmd.com/read/24513609/assembly-and-core-transformation-properties-of-two-tetrahedral-clusters-fe-iii-13p8w60o227-oh-15-h2o-2-30-and-fe-iii-13p8w60o224-oh-12-po4-4-33
#17
Pedro I Molina, Haralampos N Miras, De-Liang Long, Leroy Cronin
Two nanosized 2.6 nm Fe(III) substituted polyoxotungstates [Fe(III)13P8W60O227(OH)15(H2O)2](30-) (1) and [Fe(III)13P8W60O224(OH)12(PO4)4](33-) (2) are presented herein. Both clusters are synthesized from the reactions of trilacunary polyoxotungstate precursor [α-P2W15O56](12-) and FeCl3 under strict pH control at atmospheric pressure. The compounds are fully characterised in the solid state (FTIR and single-crystal XRD, elemental and thermogravimetric analyses), solution (cyclic voltammetry and UV-Vis spectroscopy) and in the gas phase (ESI-MS)...
April 7, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24123817/structural-and-functional-characterization-of-an-orphan-atp-binding-cassette-atpase-involved-in-manganese-utilization-and-tolerance-in-leptospira-spp
#18
Nadia Benaroudj, Frederick Saul, Jacques Bellalou, Isabelle Miras, Patrick Weber, Vincent Bondet, Gerald L Murray, Ben Adler, Paula Ristow, Hélène Louvel, Ahmed Haouz, Mathieu Picardeau
Pathogenic Leptospira species are the etiological agents of the widespread zoonotic disease leptospirosis. Most organisms, including Leptospira, require divalent cations for proper growth, but because of their high reactivity, these metals are toxic at high concentrations. Therefore, bacteria have acquired strategies to maintain metal homeostasis, such as metal import and efflux. By screening Leptospira biflexa transposon mutants for their ability to use Mn(2+), we have identified a gene encoding a putative orphan ATP-binding cassette (ABC) ATPase of unknown function...
December 2013: Journal of Bacteriology
https://www.readbyqxmd.com/read/23850511/-liver-enzymes-elevation-etiologic-study-and-efficiency-of-a-single-act-office-visit
#19
Rogger Álvaro Bendezú García, Marta Casado Martín, Marta Lázaro Sáez, Gustavo Óliver Patrón Román, Alejandra Gálvez Miras, Gonzalo P Rodríguez Laiz, Mercedes González Sánchez, José Luis Vega Sáenz
BACKGROUND: Liver enzyme (LE) elevation is a common finding in routine blood analysis. There is very little information on the most prevalent causes of these alterations in our population. In addition, a number of tests and several visits to the specialist are required to reach a diagnosis. For these reasons, we designed a protocol to streamline the evaluation of patients with LE elevations in a single-act office visit. METHODS: From March 2008 until June 2010, we studied all patients with incidental LE elevation (isolated transaminase elevation, combined elevation of alkaline phosphatase [FA] and gamma-glutamyl transpeptidase [GGT], or isolated elevation of GGT) who were referred by their primary care physicians...
August 2013: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/23782800/transcriptome-profiling-analysis-of-vibrio-vulnificus-during-human-infection
#20
Naiel Bisharat, Michal Bronstein, Mira Korner, Temima Schnitzer, Yael Koton
Vibrio vulnificus is a waterborne pathogen that was responsible for an outbreak of severe soft-tissue infections among fish farmers and fish consumers in Israel. Several factors have been shown to be associated with virulence. However, the transcriptome profile of the pathogen during human infection has not been determined yet. We compared the transcriptome profile, using RNA sequencing, of a human-pathogenic strain harvested directly from tissue of a patient suffering from severe soft-tissue infection with necrotizing fasciitis, with the same strain and three other environmental strains grown in vitro...
September 2013: Microbiology
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