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https://www.readbyqxmd.com/read/29683785/association-study-of-cacna1c-polymorphisms-with-large-artery-atherosclerotic-stroke-in-chinese-han-population
#1
Chen Peng, Ying Ding, Xin Yi, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou, Xu Chen
Aims Ischemic stroke (IS) is one of the most common diseases of neurology and the main cause of death and disability in Chinese population. CACNA1C was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of CACNA1C and ischemic stroke. Our study was designed to elucidate the relationship between four single-nucleotide polymorphisms (SNPs) variants in CACNA1C gene and the risk of large-artery atherosclerotic (LAA) stroke patients...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683355/a-novel-pcr-based-technology-for-rapid-and-non-sequencing-authentication-of-bombyx-batryticatus-using-species-specific-primers
#2
Huan Yang, Ying Zhou, Pingtian Yu, Yaya Yang, Zhaoqun Jiao, James P Tam, Yuping Shen, Xiaobin Jia
A novel PCR technology was developed to detect short DNA fragments using species-specific primers for rapid and non-sequencing authentication of Bombyx batryticatus based on differences in the mitochondrial genome. Three specifically designed primer reactions were established to target species for the reliable identification of their commercial products. They were confirmed to have a high inter-species specificity and intra-species stability. The limit of detection was estimated as 1 ng of genomes for Beauveria bassiana and 100 pg for Bombyx mori and Metarhizium anisopliae...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29683262/celecoxib-enhances-the-therapeutic-efficacy-of-epirubicin-for-novikoff-hepatoma-in-rats
#3
Tian-Huei Chu, Hoi-Hung Chan, Tsung-Hui Hu, E-Ming Wang, Yi-Ling Ma, Shih-Chung Huang, Jian-Ching Wu, Yi-Chen Chang, Wen-Tsan Weng, Zhi-Hong Wen, Deng-Chyang Wu, Yi-Ming Arthur Chen, Ming-Hong Tai
Epirubicin is a chemotherapy agent for hepatocellular carcinoma (HCC). However, the outcome of HCC patients receiving epirubicin remains unsatisfactory. Moreover, our previous study indicated that celecoxib suppresses HCC progression and liver cancer stemness. This study evaluated the potential of celecoxib to serve as a complementary therapy during epirubicin treatment. Cell proliferation, apoptosis, invasiveness, and anchorage-independent growth were analyzed in hepatoma cells. Therapeutic efficacy was validated in rat orthotopic Novikoff hepatoma...
April 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29681184/tam-infiltration-differences-in-tumor-first-and-zheng-first-models-and-the-underlying-inflammatory-molecular-mechanism-in-pancreatic-cancer
#4
Feng-Jiao Wang, Peng Wang, Lian-Yu Chen, Ya-Wen Geng, Hao Chen, Zhi-Qiang Meng, Lu-Ming Liu, Zhen Chen
BACKGROUND: Syndrome ( ZHENG in Chinese) in traditional Chinese medicine (TCM) refers to the intrinsic characteristics of a pathological process at a certain stage; these characteristics are influenced by internal and external environments and reveal the nature of a disease. Proper syndrome differentiation is the basic principle that guides clinical treatment. OBJECTIVE: To have a good understanding of tumor progression and the different mechanisms related to ZHENG that have occurred before and after tumor development and to explore the valid evaluation criteria of different pancreatic cancer syndromes to improve the guiding role of TCM syndrome differentiation in pancreatic cancer treatment...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29680783/arabidopsis-ilithyia-protein-is-necessary-for-proper-chloroplast-biogenesis-and-root-development-independent-of-eif2%C3%AE-phosphorylation
#5
I Faus, R Niñoles, V Kesari, P Llabata, E Tam, S G Nebauer, J Santiago, M T Hauser, J Gadea
One of the main mechanisms blocking translation after stress situations is mediated by phosphorylation of the α-subunit of the eukaryotic initiation factor 2 (eIF2), performed in Arabidopsis by the protein kinase GCN2 which interacts and is activated by ILITHYIA(ILA). ILA is involved in plant immunity and its mutant lines present phenotypes not shared by the gcn2 mutants. The functional link between these two genes remains elusive in plants. In this study, we show that, although both ILA and GCN2 genes are necessary to mediate eIF2α phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes...
April 12, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29680383/tumour-associated-macrophages-relation-with-progression-and-invasiveness-and-assessment-of-m1-m2-macrophages-in-canine-mammary-tumours
#6
L N Monteiro, M A Rodrigues, D A Gomes, B S Salgado, G D Cassali
Macrophages represent a major component of the overall leucocyte population within neoplasms and are important for tumour behaviour in several cancers in human beings. However, little information regarding their role in canine mammary tumours (CMTs) is available. The aim of this study was to address the potential role of tumour-associated macrophages (TAMs) in CMTs. TAMs in CMTs excised from 82 female dogs were quantified at high power (400× magnification) and categorised as low (≤50) or high (>50) TAM counts...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29678976/fostering-active-living-and-healthy-eating-through-understanding-physical-activity-and-dietary-behaviours-of-arabic-speaking-adults-a-cross-sectional-study-from-the-middle-east
#7
Tam Truong Donnelly, Tak Shing Fung, Al-Anoud Bint Mohammad Al-Thani
OBJECTIVES: Physical inactivity and unhealthy diets increase the risk for diabetes, cardiovascular diseases and cancer. Many people in Qatar are sedentary and consume diets high in fats, salt and sugar. The purpose of this study was to determine physical activity levels, food habits and understand the variables that might predict physical activity and healthy eating behaviours among Arabic-speaking adults living in the State of Qatar. SETTING: A cross-sectional community-based survey was conducted with 1606 Arab adults ≥18 years of age from March 2013 to June 2015...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677679/a-four-parameter-optimization-and-troubleshooting-of-a-rplc-charged-aerosol-detection-stability-indicating-method-for-determination-of-s-lysophosphatidylcholines-in-a-phospholipid-formulation
#8
James Tam, Imad A Haidar Ahmad, Andrei Blasko
A four parameter optimization of a stability indicating method for non-chromophoric degradation products of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1-stearoyl-sn-glycero-3-phosphocholine and 2-stearoyl-sn-glycero-3-phosphocholine was achieved using a reverse phase liquid chromatography-charged aerosol detection (RPLC-CAD) technique. Using the hydrophobic subtraction model of selectivity, a core-shell, polar embedded RPLC column was selected followed by gradient-temperature optimization, resulting in ideal relative peak placements for a robust, stability indicating separation...
April 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29677511/an-integrated-genome-wide-crispra-approach-to-functionalize-lncrnas-in-drug-resistance
#9
Assaf C Bester, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, Martin Sauvageau, Emanuele Monteleone, John L Rinn, Paolo Provero, George M Church, John G Clohessy, Pier Paolo Pandolfi
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia (AML), we developed a comprehensive and integrated genome-wide platform based on a dual protein-coding and non-coding integrated CRISPRa screening (DICaS). Putative resistance genes were initially identified using pharmacogenetic data from 760 human pan-cancer cell lines. Subsequently, genome scale functional characterization of both coding and long non-coding RNA (lncRNA) genes by CRISPR activation was performed...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29672526/structured-patient-handoff-on-an-internal-medicine-ward-a-cluster-randomized-control-trial
#10
Penny Tam, Aman P Nijjar, Mark Fok, Chris Little, Alexandra Shingina, Jesse Bittman, Rashmi Raghavan, Nadia A Khan
BACKGROUND: The effect of a multi-faceted handoff strategy in a high volume internal medicine inpatient setting on process and patient outcomes has not been clearly established. We set out to determine if a multi-faceted handoff intervention consisting of education, standardized handoff procedures, including fixed time and location for face-to-face handoff would result in improved rates of handoff compared with usual practice. We also evaluated resident satisfaction, health resource utilization and clinical outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29671926/cancer-as-a-tissue-the-significance-of-cancer-stromal-interactions-in-the-development-morphogenesis-and-progression-of-human-upper-digestive-tract-cancer
#11
REVIEW
Hiroshi Yokozaki, Yu-Ichiro Koma, Manabu Shigeoka, Mari Nishio
We review the significance of cancer-stromal interactions (CSIs) in the development, morphogenesis and progression of human gastric and esophageal cancer based on the data obtained from co-culture experiments. Orthotopic fibroblasts in the gastric cancer stroma not only promoted their growth by cancer cells but were also responsible for the mobility, morphogenesis and epithelial-to-mesenchymal transition (EMT) of the cancer cells through CSI. Bone marrow-derived mesenchymal stem cells could be part of the origin of cancer-associated fibroblasts (CAFs) of the gastric cancer providing an advantageous microenvironment for the restoration of cancer stem cells with the induction of the EMT...
April 19, 2018: Pathology International
https://www.readbyqxmd.com/read/29670880/targeting-tumor-associated-macrophages-as-a-potential-strategy-to-enhance-the-response-to-immune-checkpoint-inhibitors
#12
REVIEW
Luca Cassetta, Takanori Kitamura
Inhibition of immune checkpoint pathways in CD8+ T cell is a promising therapeutic strategy for the treatment of solid tumors that has shown significant anti-tumor effects and is now approved by the FDA to treat patients with melanoma and lung cancer. However the response to this therapy is limited to a certain fraction of patients and tumor types, for reasons still unknown. To ensure success of this treatment, CD8+ T cells, the main target of the checkpoint inhibitors, should exert full cytotoxicity against tumor cells...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29670110/tumor-associated-macrophages-promote-progression-and-the-warburg-effect-via-ccl18-nf-kb-vcam-1-pathway-in-pancreatic-ductal-adenocarcinoma
#13
Huilin Ye, Quanbo Zhou, Shangyou Zheng, Guolin Li, Qing Lin, Lusheng Wei, Zhiqiang Fu, Bin Zhang, Yimin Liu, Zhihua Li, Rufu Chen
Tumor-associated macrophages (TAMs) are frequently found near pancreatic cancer cells, but it is uncertain whether they are involved in pancreatic cancer progression and the Warburg effect. Here, we show that CCL18 secreted by TAMs facilitates malignant progression and induced a glycolytic phenotype in pancreatic cancer, partially owing to paracrine induction of VCAM-1 in pancreatic cancer cells. Reciprocally, VCAM-1-induced lactate production from pancreatic cancer cells with enhanced aerobic glycolysis activates macrophages to a TAM-like phenotype, forming a positive feedback loop...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29669207/ros-inducing-micelles-sensitize-tumor-associated-macrophages-to-tlr3-stimulation-for-potent-immunotherapy
#14
Lanlan Liu, Huamei He, Ruijing Liang, Huqiang Yi, Xiaoqing Meng, Zhikuan Chen, Hong Pan, Yifan Ma, Lintao Cai
One approach to cancer immunotherapy is the repolarization of immunosuppressive tumor-associated macrophages (TAMs) to anti-tumor M1 macrophages. The present study developed galactose-functionalized zinc protoporphyrin IX (ZnPP) grafted poly(L-lysine)-b-poly(ethyleneglycol) polypeptide micelles (ZnPP PM ) for TAM-targeted immunopotentiator delivery, which aimed at in vivo repolarization of TAMs to anti-tumor M1 macrophages. The outcomes revealed that ROS-inducing ZnPP PM demonstrated specificity for the in vitro and in vivo targeting of macrophages, elevated the level of ROS, and lowered STAT3 expression in BM-TAMs...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29667169/expression-of-scavenger-receptor-marco-defines-a-targetable-tumor-associated-macrophage-subset-in-non-small-cell-lung-cancer
#15
Linnéa La Fleur, Vanessa F Boura, Andrey Alexeyenko, Anders Berglund, Victor Pontén, Johanna Sm Mattsson, Dijana Djureinovic, Johan Persson, Hans Brunnström, Johan Isaksson, Eva Brandén, Hirsh Koyi, Patrick Micke, Mikael Ci Karlsson, Johan Botling
Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated the expression of MARCO in relation to other macrophage markers and immune pathways in a non-small cell lung cancer (NSCLC) cohort (n=352). MARCO, CD68, CD163, MSR1 and programmed death ligand-1 (PD-L1) were analyzed by immunohistochemistry and immunofluorescence, and associations to other immune cells and regulatory pathways were studied in a subset of cases (n=199) with available RNA-seq data...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29663845/a-24-month-advanced-magnetic-resonance-imaging-study-of-multiple-sclerosis-patients-treated-with-alemtuzumab
#16
Irene M Vavasour, Roger Tam, David Kb Li, Cornelia Laule, Carolyn Taylor, Shannon H Kolind, Alex L MacKay, Adil Javed, Anthony Traboulsee
BACKGROUND: Tissue damage in both multiple sclerosis (MS) lesions and normal-appearing white matter (NAWM) are important contributors to disability and progression. Specific aspects of MS pathology can be measured using advanced imaging. Alemtuzumab is a humanised monoclonal antibody targeting CD52 developed for MS treatment. OBJECTIVE: To investigate changes over 2 years of advanced magnetic resonance (MR) metrics in lesions and NAWM of MS patients treated with alemtuzumab...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29662092/diffusion-limited-growth-of-microbial-colonies
#17
Hayden Tronnolone, Alexander Tam, Zoltán Szenczi, J E F Green, Sanjeeva Balasuriya, Ee Lin Tek, Jennifer M Gardner, Joanna F Sundstrom, Vladimir Jiranek, Stephen G Oliver, Benjamin J Binder
The emergence of diffusion-limited growth (DLG) within a microbial colony on a solid substrate is studied using a combination of mathematical modelling and experiments. Using an agent-based model of the interaction between microbial cells and a diffusing nutrient, it is shown that growth directed towards a nutrient source may be used as an indicator that DLG is influencing the colony morphology. A continuous reaction-diffusion model for microbial growth is employed to identify the parameter regime in which DLG is expected to arise...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661833/no-is-required-for-memory-formation-and-expression-of-memory-and-for-minor-behavioral-changes-during-training-with-inedible-food-in-aplysia
#18
Valeria Briskin-Luchinsky, Shlomit Tam, Shlomit Shabbat, Itay Hurwitz, Abraham J Susswein
A learning experience may lead to changes in behavior during the experience, and also to memory expressed at a later time. Are signals causing changes in behavior during the learning experience related to the formation and expression of memory? We examined this question, using learning that food is inedible in Aplysia Treatment of an isolated buccal ganglia preparation with an NO donor elicited rejection-like motor programs. Rejection initiated by NO production is consistent with aspects of behavioral changes seen while animals learn, and with memory formation...
May 2018: Learning & Memory
https://www.readbyqxmd.com/read/29661164/helicase-like-transcription-factor-expression-is-associated-with-a-poor-prognosis-in-non-small-cell-lung-cancer-nsclc
#19
Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao, Céline Mascaux
BACKGROUND: The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like Transcription Factor (HLTF) is a tumor suppressor, altered in cancer either by gene hypermethylation or mRNA alternative splicing. This study assessed the expression and the clinical relevance of wild-type (WT) and variant forms of HLTF RNAs in NSCLC. METHODS: We analyzed online databases (TCGA, COSMIC) for HLTF alterations in NSCLC and assessed WT and spliced HLTF mRNAs expression by RT-ddPCR in 39 lung cancer cell lines and 171 patients with resected stage I-II NSCLC...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29660746/free-versus-pedicled-perforator-flaps-for-lower-extremity-reconstruction-a-multicenter-comparison-of-institutional-practices-and-outcomes
#20
Keith Koh, Terence L H Goh, Christopher Tam Song, Hyun Suk Suh, Peter V Rovito, Joon-Pio Hong, Geoffrey G Hallock
BACKGROUND:  Of all body regions, lower extremity wounds have been and remain the greatest challenge. Perforator free flaps have been accepted as a reasonable option to solve this dilemma but require the complexity of microsurgery. As a consequence, the possibility that pedicled perforator flaps could supplant even perforator free flaps has recently gained intense enthusiasm. METHODS:  A retrospective investigation was undertaken to compare the validity for the use of perforator flaps of all types at three dissimilar institutions, that is, a university, a regional center, and a community hospital...
April 16, 2018: Journal of Reconstructive Microsurgery
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