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https://www.readbyqxmd.com/read/29028675/the-risk-of-stroke-in-physicians-a-population-based-cohort-study-in-taiwan
#1
Hon-Pheng Tam, Hung-Jung Lin, Shih-Feng Weng, Chien-Chin Hsu, Jhi-Joung Wang, Shih-Bin Su, Chien-Cheng Huang, How-Ran Guo
BACKGROUND: Physicians in Taiwan work in stressful workplaces and have heavy workloads, both of which may contribute to the occurrence of a stroke. However, it is not clear whether they have a higher risk of stroke. Therefore, we conducted a population-based cohort study to compare the risks of stroke between physicians and the general population and among subgroups of physicians in Taiwan. METHODS: In the National Health Insurance Research Database of Taiwan, we identified 28,062 physicians and selected 84,186 age- and sex-matched nonmedical staff beneficiaries as the references...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028315/nanoparticles-of-short-cationic-peptidopolysaccharide-self-assembled-by-hydrogen-bonding-with-antibacterial-effect-against-multi-drug-resistant-bacteria
#2
Zheng Hou, Yogesh Vikhe Shankar, Yang Liu, Feiqing Ding, Jothy Lachumy Subramanion, Vikashini Ravikumar, Rubí Zamudio-Vázquez, Damien Keogh, Huiwen Lim, Moon Yue Feng Tay, Surajit Bhattacharjya, Scott A Rice, Jian Shi, Hongwei Duan, Xue-Wei Liu, Yuguang Mu, Nguan Soon Tan, Kam Michael Chiu Tam, Kevin Pethe, Mary B Chan-Park
Cationic antimicrobial peptides (AMPs) and polymers are active against many multi-drug resistant (MDR) bacteria but only a limited number of these compounds are in clinical use due to their unselective toxicity. The typical strategy for achieving selective antibacterial efficacy with low mammalian cell toxicity is through balancing the ratio of cationicity to hydrophobicity. Herein, we report a cationic nanoparticle self-assembled from chitosan-graft-oligolysine (CSM5-K5) chains with ultra-low molecular weight (1450 Daltons) that selectively kills bacteria...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29027979/molecular-mechanics-of-the-moisture-effect-on-epoxy-carbon-nanotube-nanocomposites
#3
Lik-Ho Tam, Chao Wu
The strong structural integrity of polymer nanocomposite is influenced in the moist environment; but the fundamental mechanism is unclear, including the basis for the interactions between the absorbed water molecules and the structure, which prevents us from predicting the durability of its applications across multiple scales. In this research, a molecular dynamics model of the epoxy/single-walled carbon nanotube (SWCNT) nanocomposite is constructed to explore the mechanism of the moisture effect, and an analysis of the molecular interactions is provided by focusing on the hydrogen bond (H-bond) network inside the nanocomposite structure...
October 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29027937/abrin-toxicity-and-bioavailability-after-temperature-and-ph-treatment
#4
Christina C Tam, Thomas D Henderson, Larry H Stanker, Xiaohua He, Luisa W Cheng
Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and an in vivo mouse bioassay. pH treatment of abrin had no detrimental effect on its stability and toxicity as seen either in vitro or in vivo. Abrin exposure to increasing temperatures did not completely abrogate protein translation...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29026551/extrinsic-pulmonary-artery-compression-mimicking-acute-pulmonary-embolism
#5
Jonathan Xinguo Fang, Benjamin Xinhao Fang, Cheung-Chi Simon Lam, Pak-Hei Chan, Frankie Choi-Cheung Tam, Chung-Wah Siu
Right ventricular strain patterns on electrocardiogram such as right axis derivation and S1Q3T3 are well known for their diagnostic value in cases of acute pulmonary embolism. Nonetheless, these changes are not pathognomonic. We report a patient with electrocardiographic evidence of right ventricular strain secondary to an unusual etiology.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29026049/diabetes-in-older-people-position-statement-of-the-hong-kong-geriatrics-society-and-the-hong-kong-society-of-endocrinology-metabolism-and-reproduction
#6
C W Wong, J Sw Lee, K F Tam, H F Hung, W Y So, C K Shum, C Y Lam, J N Cheng, S P Man, T W Auyeung
Following a survey on the clinical practice of geriatricians in the management of older people with diabetes and a study of hypoglycaemia in diabetic patients, a round-table discussion with geriatricians and endocrinologists was held in January 2015. Consensus was reached for six domains specifically related to older diabetic people: (1) the considerations when setting an individualised diabetic management; (2) inclusion of geriatric syndrome screening in assessment; (3) glycaemic and blood pressure targets; (4) pharmacotherapy; (5) restrictive diabetic diet; and (6) management goals for nursing home residents...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29024938/expression-and-role-of-tyro3-and-axl-as-potential-therapeutical-targets-in-leiomyosarcoma
#7
Carmela Dantas-Barbosa, Tom Lesluyes, François Le Loarer, Fréderic Chibon, Isabelle Treilleux, Jean-Michel Coindre, Pierre Meeus, Mehdi Brahmi, Olivia Bally, Isabelle Ray-Coquard, Marie-Pierre Sunyach, Axel Le Cesne, Olivier Mir, Sylvie Bonvalot, Maud Toulmonde, Antoine Italiano, Pierre Saintigny, Myriam Jean-Denis, Francoise Ducimetiere, Dominique Ranchere, Hiba El Sayadi, Laurent Alberti, Jean-Yves Blay
BACKGROUND: Leiomyosarcoma (LMS) are 15% of adult sarcomas and remain seldom curable in metastatic phase. The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. METHODS: The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. TYRO3 and AXL were knocked down. Crizotinib and foretinib were investigated in vitro. RESULTS: High expression of TYRO3 and AXL was detected in LMS cell lines...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29024813/a-prodrug-of-green-tea-polyphenol-epigallocatechin-3-gallate-pro-egcg-serves-as-a-novel-angiogenesis-inhibitor-in-endometrial-cancer
#8
Jianzhang Wang, Gene Chi Wai Man, Tak Hang Chan, Joseph Kwong, Chi Chiu Wang
Anti-angiogenesis effect of a prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer. Tumor xenografts of human endometrial cancer were established and subjected to microarray analysis after Pro-EGCG treatment. First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining...
October 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29024520/allergen-immunotherapy-exploring-areas-for-further-inquiry
#9
Tam Ramsey, Wanda Lai, Peter F Svider, Houmehr Hojjat, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS: On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29024269/fluid-resuscitation-in-patients-with-severe-burns-a-meta-analysis-of-randomized-controlled-trials
#10
Yuan Kao, El-Wui Loh, Chien-Chin Hsu, Hung-Jung Lin, Chien-Cheng Huang, Yun-Yun Chou, Chieh-Chun Lien, Ka-Wai Tam
OBJECTIVES: Fluid resuscitation is the mainstay treatment to reconstitute intravascular volume and maintain end-organ perfusion in patients with severe burns. The use of a hyper-osmotic or iso-osmotic solution in fluid resuscitation to manage myocardial depression and increased capillary permeability during burn shock has been debated. We conducted a systematic review and meta-analysis to compare the efficacies of hyper-osmotic and iso-osmotic solutions in restoring hemodynamic stability after burn injuries...
October 11, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29022575/gefitinib-inhibits-m2-like-polarization-of-tumor-associated-macrophages-in-lewis-lung-cancer-by-targeting-the-stat6-signaling-pathway
#11
Muhammad Tariq, Jie-Qiong Zhang, Gui-Kai Liang, Qiao-Jun He, Ling Ding, Bo Yang
M2-like polarized tumor-associated macrophages (TAMs) play a pivotal role in promoting cancer cell growth, invasion, metastasis and angiogenesis. The identification of M2-like TAMs during tumor progression is an attractive approach for cancer therapy. In this study, we investigated the relevance of macrophage polarization and the antitumor effect of gefitinib in Lewis Lung cancer (LLC) in vitro and in vivo. Gefitinib at a concentration below 2.5 μmol/L did not cause significant growth inhibition on LLC and RAW 264...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29022111/a-novel-strain-of-porcine-deltacoronavirus-in-vietnam
#12
Van Phan Le, Sok Song, Byung-Hyun An, Gyu-Nam Park, Ngoc Thach Pham, Dinh Quyen Le, Van Tam Nguyen, Thi Thu Hang Vu, Ki-Sun Kim, SeEun Choe, Dong-Jun An
Two porcine deltacoronavirus (PDCoV) strains (Binh21 and HaNoi6) were isolated from two pig farms in North Vietnam. Phylogenetic analysis of the complete genomes and the Spike and Membrane genes revealed that the two Vietnam PDCoVs belong to the same lineage as PDCoVs from Thailand and Laos; however, the N genes belonged to the same lineage as PDCoVs from the USA, Korea, China, and Hong Kong. The recombination detection program subsequently identified the major parent (S5011 strain) and minor parent (HKU15-44 strain) of the two Vietnam PDCoV strains (p < 0...
October 11, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29020940/the-epidemiology-and-transmission-of-methicillin-resistant-staphylococcus-aureus-in-the-community-in-singapore-study-protocol-for-a-longitudinal-household-study
#13
Nivedita Shankar, Angela Li Ping Chow, Jolene Oon, Li Yang Hsu, Brenda Ang, Junxiong Pang, Paola Florez De Sessions, Balamurugan Periaswamy, Paul A Tambyah, Desmond B Teo, Clarence C Tam
BACKGROUND/AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission. METHODS: MRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29019987/establishment-of-mouse-expanded-potential-stem-cells
#14
Jian Yang, David J Ryan, Wei Wang, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A Kolodziejczyk, Lia S Campos, Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie A Eckersley-Maslin, Michael Woods, Yosuke Tanaka, Xi Chen, Adam C Wilkinson, James Bussell, Jacqui White, Ramiro Ramirez-Solis, Wolf Reik, Berthold Göttgens, Sarah A Teichmann, Patrick P L Tam, Hiromitsu Nakauchi, Xiangang Zou, Liming Lu, Pentao Liu
Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst. Here we report that cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells. Remarkably, a single expanded potential stem cell can contribute both to the embryo proper and to the trophectoderm lineages in a chimaera assay...
October 11, 2017: Nature
https://www.readbyqxmd.com/read/29019578/nutritional-assessment-methods-as-predictors-of-postoperative-mortality-in-gastric-cancer-patients-submitted-to-gastrectomy
#15
Aline Kirjner Poziomyck, Leandro Totti Cavazzola, Luisa Jussara Coelho, Edson Braga Lameu, Antonio Carlos Weston, Luis Fernando Moreira
OBJECTIVES: to determine the nutritional evaluation method that best predicts mortality in 90 days of patients submitted to gastrectomy for gastric cancer. METHODS: we conducted a prospective study with 44 patients with gastric cancer, stages II to IIIa, of whom nine were submitted to partial gastrectomy, 34 to total gastrectomy, and one to esophago-gastrectomy. All patients were nutritionally evaluated through the same protocol, up to 72h after hospital admission...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28994114/macrophage-subtypes-in-recurrent-nodular-basal-cell-carcinoma-after-mohs-micrographic-surgery
#16
Emerson H Padoveze, Nilton Di Chiacchio, Jorge Ocampo-Garza, Selma S Cernea, Walter Belda, Mirian N Sotto
BACKGROUND: The macrophages associated with solid tumors are related to the progression or regression of tumors, depending on the differentiation in M1 or M2. M2 subtype promotes angiogenesis, remodeling, and tissue repair (tumor proliferation). In contrast, M1 produces toxic mediators and presents antigens, destroying microorganisms and tumor cells. The microenvironment of most aggressive forms of basal cell carcinoma (BCC) shows an increase in macrophages due to M2 phenotype compared to noninvasive forms...
October 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28992900/cultural-differences-in-symptom-representation-for-depression-and-somatization-measured-by-the-phq-between-vietnamese-and-german-psychiatric-outpatients
#17
Annegret Dreher, Eric Hahn, Albert Diefenbacher, Main Huong Nguyen, Kerem Böge, Hannah Burian, Michael Dettling, Ronald Burian, Thi Minh Tam Ta
OBJECTIVE: Despite an extensive body of research on somatic symptom presentation among people of East- and Southeast-Asian descent, results are still inconclusive. Examining and comparing symptom presentation in clinically and ethnically well-characterized populations may constitute a step towards understanding symptom presentation between patients with a different cultural background. This study aims to compare Vietnamese and German patients regarding cultural dynamics of symptom presentation upon first admission to a psychiatric outpatient service...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28991491/nanowire-aptasensors-for-electrochemical-detection-of-cell-secreted-cytokines
#18
Ying Liu, Ali Rahimian, Sergiy Krylyuk, Tam Vu, Bruno Crulhas, Gulnaz Stybayeva, Meruyert Imanbekova, Dong-Sik Shin, Albert Davydov, Alexander Revzin
Cytokines are small proteins secreted by immune cells in response to pathogens/infections; therefore, these proteins can be used in diagnosing infectious diseases. For example, release of a cytokine interferon (IFN)-γ from T-cells is used for blood-based diagnosis of tuberculosis (TB). Our lab has previously developed an atpamer-based electrochemical biosensor for rapid and sensitive detection of IFN-γ. In this study, we explored the use of silicon nanowires (NWs) as a way to create nanostructured electrodes with enhanced sensitivity for IFN-γ...
October 9, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28991472/the-discovery-of-a-dual-ttk-protein-kinase-cdc2-like-kinase-clk2-inhibitor-for-the-treatment-of-triple-negative-breast-cancer-initiated-from-a-phenotypic-screen
#19
Jennifer R Riggs, Mark Nagy, Jan Elsner, Paul Erdman, Dan Cashion, Dale Robinson, Roy Harris, Dehua Huang, Lida Tehrani, Gordafaried Deyanat-Yazdi, Rama Krishna Narla, Xiaohui Peng, Tam Tran, Leo Barnes, Terra Miller, Jason Katz, Yang Tang, Ming Chen, Mehran F Moghaddam, Sogole Bahmanyar, Barbra Pagarigan, Silvia L Delker, Laurie LeBrun, Philip Paul Chamberlain, Andrew Calabrese, Stacie S Canan, Katerina Leftheris, Dan Zhu, John F Boylan
Triple negative breast cancer (TNBC) remains a serious unmet medical need with discouragingly high relapse rates. We report here the synthesis and structure-activity relationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines with potent activity against TNBC tumor cell lines. These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition profile targeting TTK (mitotic exit) and CLK2 (mRNA splicing). Design and optimization, driven with a TNBC tumor cell assay, identified potent and selective compounds with favorable in vitro and in vivo activity profiles and good iv PK properties...
October 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28991409/effects-of-seasonal-and-pandemic-influenza-on-health-related-quality-of-life-work-and-school-absence-in-england-results-from-the-flu-watch-cohort-study
#20
Ellen B Fragaszy, Charlotte Warren-Gash, Peter J White, Maria Zambon, W John Edmunds, Jonathan S Nguyen-Van-Tam, Andrew C Hayward
BACKGROUND: Estimates of health-related quality of life (HRQoL) and work/school absences for influenza are typically based on medically-attended cases or those meeting influenza-like-illness (ILI) case definitions, and thus biased towards severe disease. Although community influenza cases are more common, estimates of their effects on HRQoL and absences are limited. OBJECTIVES: To measure Quality-Adjusted Life Days and Years (QALDs and QALYs) lost and work/school absences among community cases of acute respiratory infections (ARI), ILI and influenza A and B and to estimate community burden of QALY loss and absences from influenza...
October 9, 2017: Influenza and Other Respiratory Viruses
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