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https://www.readbyqxmd.com/read/28211684/the-reactivity-of-germanium-phosphanides-with-chalcogens
#1
Lisa M Harris, Eric C Y Tam, Struan J W Cummins, Martyn P Coles, J Robin Fulton
The reactivity of germanium phosphanido complexes with elemental chalcogens is reported. Addition of sulfur to [(BDI)GePCy2] (BDI = CH{(CH3)CN-2,6-iPr2C6H3}2) results in oxidation at germanium to form germanium(IV) sulfide [(BDI)Ge(S)PCy2] and oxidation at both germanium and phosphorus to form germanium(IV) sulfide dicylohexylphosphinodithioate complex [(BDI)Ge(S)SP(S)Cy2], whereas addition of tellurium to [(BDI)GePCy2] only gives the chalcogen inserted product, [(BDI)GeTePCy2]. This reactivity is different from that observed between [(BDI)GePCy2] and selenium...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211358/a-prospective-interventional-study-to-examine-the-effect-of-a-silver-alloy-and-hydrogel-coated-catheter-on-the-incidence-of-catheter-associated-urinary-tract-infection
#2
P Hy Chung, C Wy Wong, C Kc Lai, H K Siu, D Nc Tsang, K Y Yeung, D Km Ip, P Kh Tam
INTRODUCTION: Catheter-associated urinary tract infection is a major hospital-acquired infection. This study aimed to analyse the effect of a silver alloy and hydrogel-coated catheter on the occurrence of catheter-associated urinary tract infection. METHODS: This was a 1-year prospective study conducted at a single centre in Hong Kong. Adult patients with an indwelling urinary catheter for longer than 24 hours were recruited. The incidence of catheter-associated urinary tract infection in patients with a conventional latex Foley catheter without hydrogel was compared with that in patients with a silver alloy and hydrogel-coated catheter...
February 17, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28210718/synthesis-and-epr-spectroscopic-characterization-of-the-perchlorotriarylmethyl-tricarboxylic-acid-radical-ptmtc-and-its-13-c-labelled-analogue-13c-ptmtc
#3
Marwa Elewa, Nadica Maltar-Strmečki, Mohamed M Said, Hosam A El Shihawy, Mohamed El-Sadek, Juliane Frank, Simon Drescher, Malte Drescher, Karsten Mäder, Dariush Hinderberger, Peter Imming
A hydrophilic tris(tetrachlorotriaryl)methyl (tetrachloro-TAM) radical labelled 50% with (13)C at the central carbon atom was prepared. The mixture of isotopologue radicals was characterised by continuous wave and pulsed X-band electron paramagnetic spectroscopy (EPS). For the pharmaceutical and medical applications planned, the quantitative influence of oxygen, viscosity, temperature and pH on EPR line widths was studied in aqueous buffer, DMSO, water-methanol and water-glycerol mixtures. Under in vivo conditions, pH can be disregarded...
February 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28210337/extraction-of-knowledge-from-the-topographic-attentive-mapping-network-and-its-application-in-skill-analysis-of-table-tennis
#4
Isao Hayashi, Masanori Fujii, Toshiyuki Maeda, Jasmin Leveille, Tokio Tasaka
The Topographic Attentive Mapping (TAM) network is a biologically-inspired classifier that bears similarities to the human visual system. In case of wrong classification during training, an attentional top-down signal modulates synaptic weights in intermediate layers to reduce the difference between the desired output and the classifier's output. When used in a TAM network, the proposed pruning algorithm improves classification accuracy and allows extracting knowledge as represented by the network structure...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28209156/breastdefend-enhances-effect-of-tamoxifen-in-estrogen-receptor-positive-human-breast-cancer-in-vitro-and-in-vivo
#5
Shujie Cheng, Victor Castillo, Matt Welty, Mark Alvarado, Isaac Eliaz, Constance J Temm, George E Sandusky, Daniel Sliva
BACKGROUND: Tamoxifen (TAM) has been widely used for the treatment of estrogen receptor (ER)-positive breast cancer and its combination with other therapies is being actively investigated as a way to increase efficacy and decrease side effects. Here, we evaluate the therapeutic potential of co-treatment with TAM and BreastDefend (BD), a dietary supplement formula, in ER-positive human breast cancer. METHODS: Cell proliferation and apoptosis were determined in ER-positive human breast cancer cells MCF-7 by MTT assay, quantitation of cytoplasmic histone-associated DNA fragments and expression of cleaved PARP, respectively...
February 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28208378/reconstructing-links-in-directed-networks-from-noisy-dynamics
#6
Emily S C Ching, H C Tam
We address the long-standing challenge of how to reconstruct links in directed networks from measurements, and present a general method that makes use of a noise-induced relation between network structure and both the time-lagged covariance of measurements taken at two different times and the covariance of measurements taken at the same time. When the coupling functions have certain additional properties, we can further reconstruct the weights of the links.
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207609/ischemic-central-retinal-vein-occlusion-in-the-anti-vascular-endothelial-growth-factor-era
#7
Emily K Tam, Pamela Golchet, Madeline Yung, Francis C DeCroos, Marc Spirn, Lydia Lehmann-Clarke, Aude Ambresin, Irena Tsui
PURPOSE: Anti-vascular endothelial growth factor therapy has improved the prognosis for patients with central retinal vein occlusion (CRVO). However, most studies published to date exclude ischemic CRVO. The purpose of this study was to describe the outcome in eyes with ischemic CRVO treated with anti-vascular endothelial growth factor therapy. METHODS: Thirty-seven patients with ischemic CRVO from 3 centers were followed for at least 6 months. Data on patient demographic, vision status, and anti-vascular endothelial growth factor treatments were collected...
February 15, 2017: Retina
https://www.readbyqxmd.com/read/28207000/spatial-transcriptomic-analysis-of-cryosectioned-tissue-samples-with-geo-seq
#8
Jun Chen, Shengbao Suo, Patrick Pl Tam, Jing-Dong J Han, Guangdun Peng, Naihe Jing
Conventional gene expression studies analyze multiple cells simultaneously or single cells, for which the exact in vivo or in situ position is unknown. Although cellular heterogeneity can be discerned when analyzing single cells, any spatially defined attributes that underpin the heterogeneous nature of the cells cannot be identified. Here, we describe how to use Geo-seq, a method that combines laser capture microdissection (LCM) and single-cell RNA-seq technology. The combination of these two methods enables the elucidation of cellular heterogeneity and spatial variance simultaneously...
March 2017: Nature Protocols
https://www.readbyqxmd.com/read/28205464/a-new-classification-scheme-for-closed-avulsion-injuries-of-the-flexor-digitorum-profundus-tendon
#9
Mokhtar Abdul Azeem, Yousef Marwan, Ahmed El Morshidy, Ali Esmaeel, Yehia Zakaria
BACKGROUND: Closed avulsion injury of the flexor digitorum profundus (FDP) tendon is a relatively common condition of the hand. Its present classification system seems to be deficient in including all possible patterns of injury, leading to improper selection of the best treatment method for the injury. We aim to provide a new classification scheme for this injury. METHODS: We developed a new classification scheme based on the possible pattern of FDP tendon injury...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28202857/cytokine-profiles-in-pericardial-effusion-in-a-down-syndrome-infant-with-transient-abnormal-myelopoiesis
#10
Yoshihiko Shitara, Naoto Takahashi, Yoshinori Aoki, Motohiro Kato, Riki Nishimura, Shinya Tsuchida, Akira Oka
Infants with Down Syndrome (DS) are at risk of developing a transient abnormal myelopoiesis (TAM). TAM is characterised by increased circulating blast cells but usually self-limiting. DS patients with TAM sometimes show fetal hydrops and effusion in body cavities, but the mechanism remains unclear. We report here a case of infant with DS who had pericardial effusion, TAM, and eosinophilia. In her pericardial effusion, white blood cell count was 6.0 × 10(3)/µL, 41% of which were eosinophils. After administration of prednisolone, pericardial effusion gradually decreased, and TAM and eosinophilia improved...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202524/scavenger-receptor-a1-prevents-metastasis-of-non-small-cell-lung-cancer-via-suppression-of-macrophage-serum-amyloid-a1
#11
Yan Zhang, Yongyue Wei, Bin Jiang, Lili Chen, Hui Bai, Xudong Zhu, Xiaoyu Li, Hanwen Zhang, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben, David C Christiani, Qi Chen
Mechanisms of crosstalk between tumor cells and tumor-associated macrophages (TAM) which drive metastasis are not fully understood. Scavenger receptor A1 (SR-A1) expressed primarily in macrophages has been associated with lung tumorigenesis. In this study, we used population genetics, transcriptomics and functional analyses to uncover how SR-A1 is involved in lung cancer and its prognosis. SR-A1 genetic variants were investigated for possible association with survival of advanced-stage NSCLC patients in the Harvard Lung Cancer Study cohort...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28202512/tumor-associated-neutrophils-and-macrophages-promote-gender-disparity-in-hepatocellular-carcinoma-in-zebrafish
#12
Chuan Yan, Qiqi Yang, Zhiyuan Gong
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than women, but the mechanistic basis of this gender disparity is obscure. Chronic inflammation is a major etiological factor in HCC, so we investigated the role of cortisol in gender discrepancy in a zebrafish model of HCC. Inducible expression of oncogenic KrasV12 in hepatocytes of transgenic zebrafish resulted in accelerated liver tumor progression in males. These tumors were more heavily infiltrated with tumor-associated neutrophils (TAN) and macrophages (TAM) versus females, and they both showed pro-tumor gene expression and promoted tumor progression...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28199524/impact-of-outpatient-neuraminidase-inhibitor-treatment-in-patients-infected-with-influenza-a-h1n1-pdm09-at-high-risk-of-hospitalization-an-individual-participant-data-ipd-meta-analysis
#13
Sudhir Venkatesan, Puja R Myles, Jo Leonardi-Bee, Stella G Muthuri, Malak Al Masri, Nick Andrews, Carlos Bantar, Gal Dubnov-Raz, Patrick Gérardin, Evelyn Sc Koay, Tze Ping Loh, Ziad Memish, Elizabeth Miller, Maria E Oliva, Barbara A Rath, Brunhilde Schweiger, Julian W Tang, Dat Tran, Tjasa Vidmar, Pauline A Waight, Jonathan S Nguyen-Van-Tam
No abstract text is available yet for this article.
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28199119/engineering-a-catalytically-efficient-recombinant-protein-ligase
#14
Renliang Yang, Yee Hwa Wong, Giang K T Nguyen, James P Tam, Julien Lescar, Bin Wu
Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein chemistry. Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-producing plant oldenlandia affinis that displayed weak peptide cyclase activity, despite having a similar structural fold with other asparaginyl endopeptidases (AEP). Here we report the first atomic structure of OaAEP1, at a resolution of 2.56 Å, in its pre-activation form. Our structure and biochemical analysis of this enzyme reveals its activation mechanism as well as structural features important for its ligation activity...
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28197369/the-transcriptome-of-lung-tumor-infiltrating-dendritic-cells-reveals-a-tumor-supporting-phenotype-and-a-microrna-signature-with-negative-impact-on-clinical-outcome
#15
Lotte Pyfferoen, Elisabeth Brabants, Celine Everaert, Nancy De Cabooter, Kelly Heyns, Kim Deswarte, Manon Vanheerswynghels, Sofie De Prijck, Glenn Waegemans, Melissa Dullaers, Hamida Hammad, Olivier De Wever, Pieter Mestdagh, Jo Vandesompele, Bart N Lambrecht, Karim Y Vermaelen
Targeting immunomodulatory pathways has ushered a new era in lung cancer therapy. Further progress requires deeper insights into the biology of immune cells in the lung cancer micro-environment. Dendritic cells (DCs) represent a heterogeneous and highly plastic immune cell system with a central role in controlling immune responses. The intratumoral infiltration and activation status of DCs are emerging as clinically relevant parameters in lung cancer. In this study, we used an orthotopic preclinical model of lung cancer to dissect how the lung tumor micro-environment affects tissue-resident DCs and extract novel biologically and clinically relevant information...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28197019/inflammation-and-cancer-extra-and-intracellular-determinants-of-tumor-associated-macrophages-as-tumor-promoters
#16
REVIEW
Gabor J Szebeni, Csaba Vizler, Klara Kitajka, Laszlo G Puskas
One of the hallmarks of cancer-related inflammation is the recruitment of monocyte-macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid cells are educated by the tumor milieu, rich in cancer cells and stroma components, to exert functions such as promotion of tumor growth, immunosuppression, angiogenesis, and cancer cell dissemination. Our review highlights the ontogenetic diversity of tumor-associated macrophages (TAMs) and describes their main phenotypic markers. We cover fundamental molecular players in the tumor microenvironment including extra- (CCL2, CSF-1, CXCL12, IL-4, IL-13, semaphorins, WNT5A, and WNT7B) and intracellular signals...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28197001/perceived-stigma-of-mental-illness-a-comparison-between-two-metropolitan-cities-in-india
#17
Aron Zieger, Aditya Mungee, Georg Schomerus, Thi Minh Tam Ta, Michael Dettling, Matthias C Angermeyer, Eric Hahn
PURPOSE: An increasing number of comparative studies are conducted on the stigmatization of persons with mental illness, in particular with regard to regional and diachronic variation. So far, there have been no studies comparing stigmatization of persons with mental illness in two different regions of India. Therefore, we examined the differences in perception of stigma attached to mental illnesses in Kolkata and Chennai, with regard to cultural and geographical differences to better understand the roots and origins of this issue...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28196877/using-quantitative-mass-spectrometry-to-better-understand-the-influence-of-genetics-and-nutritional-perturbations-on-the-virulence-potential-of-staphylococcus-aureus
#18
Jessica R Chapman, Divya Balasubramanian, Kayan Tam, Manor Askenazi, Richard Copin, Bo Shopsin, Victor J Torres, Beatrix Ueberheide
Staphylococcus aureus (Sa) is the leading cause of a variety of bacterial infections ranging from superficial skin infections to invasive and life threatening diseases such as septic bacteremia, necrotizing pneumonia, and endocarditis. The success of Sa as a human pathogen is due to its ability to adapt to the environment by changing expression, production, or secretion of virulence factors. Although Sa immune evasion is well-studied, the regulation of virulence factors under different nutrient and growth conditions is still not well understood...
February 14, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28196089/taxes-and-subsidies-for-improving-diet-and-population-health-in-australia-a-cost-effectiveness-modelling-study
#19
Linda J Cobiac, King Tam, Lennert Veerman, Tony Blakely
BACKGROUND: An increasing number of countries are implementing taxes on unhealthy foods and drinks to address the growing burden of dietary-related disease, but the cost-effectiveness of combining taxes on unhealthy foods and subsidies on healthy foods is not well understood. METHODS AND FINDINGS: Using a population model of dietary-related diseases and health care costs and food price elasticities, we simulated the effect of taxes on saturated fat, salt, sugar, and sugar-sweetened beverages and a subsidy on fruits and vegetables, over the lifetime of the Australian population...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28194508/open-reduction-and-internal-fixation-for-intraarticular-fracture-of-metacarpal-head
#20
Jun-Ku Lee, Yong-Gil Jo, Ji-Woong Kim, Yun Seong Choi, Soo-Hong Han
Intraarticular fracture of the metacarpophalangeal (MP) joint presents complex problems related to the sophisticated functional aspects of the hand. Injury to the metacarpal head may have a severe effect on hand function but few studies have investigated the management of this condition. In this study, we applied open reduction and internal fixation for the displaced fracture of the metacarpal head and report the clinical and radiographic outcomes of our experience. Thirteen patients (12 men, 1 woman; mean age 21 years) were included in this study, and medical records and radiographs were reviewed retrospectively...
February 13, 2017: Der Orthopäde
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