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https://www.readbyqxmd.com/read/29896224/nicotine-reduces-effectiveness-of-doxorubicin-chemotherapy-and-promotes-cd44-cd24-cancer-stem-cells-in-mcf-7-cell-populations
#1
Leyla Türker Şener, Celal Güven, Aziz Şener, Suzan Adin Çinar, Seyhun Solakoğlu, Işil Albeniz
Breast cancer is the most common type of cancer in females and the second most common cause of cancer mortality after lung cancer. Cancer stem cells represent a novel approach to target cancer and reduce cancer recurrence and metastasis. Many patients with breast cancer continue to smoke after receiving their diagnosis. Nicotine is a key factor in tobacco addiction and also changes some cellular functions, such as activation of mitogenic pathways, angiogenesis and cell proliferation. In the present study, the impact of nicotine was assessed in a population of MCF-7 human breast cancer cells...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29890181/prevalence-and-risk-factors-of-antibodies-to-human-leukocyte-antigens-in-haploidentical-stem-cell-transplantation-candidates-a-multi-center-study
#2
Ming-Rui Huo, Ya-Jing Xu, Shu-Zhen Zhai, Meng Lv, Yu Wang, Le-Qing Cao, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Wei Han, Yu-Qian Sun, Chen-Hua Yan, Fei-Fei Tang, Xiao-Dong Mo, Ming-Feng Zhao, Kai-Yan Liu, Xiao-Jun Huang, Ying-Jun Chang
We investigated the prevalence of and risk factors for antibodies to HLA in 1,663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P=0.018), prior transfusions (P<0.001) or pregnancy (P<0.001), and cases with MDS (P=0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P=0...
June 8, 2018: Human Immunology
https://www.readbyqxmd.com/read/29888111/chd4-mutations-promote-endometrial-cancer-stemness-by-activating-tgf-beta-signaling
#3
Yang Li, Qingxin Liu, Daniel J McGrail, Hui Dai, Kaiyi Li, Shiaw-Yih Lin
Endometrial cancer is one of the most common cancers of the female reproductive system. CHD4, a core subunit of the nucleosome remodeling and deacetylation (NuRD) complex, is frequently mutated in these patients. However the role it plays in promoting endometrial tumorigenesis is poorly understood. Here, we use genetic engineering approaches to modulate CHD4 expression levels and functionally evaluate hot spot mutations R975H and R1162W. We find that CHD4 depletion induces up-regulation of the cancer stem cell (CSC) marker CD133...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29887366/germline-stem-cell-heterogeneity-supports-homeostasis-in-drosophila
#4
Amanda Yunn Ee Ng, Kimberly Rae Guzman Peralta, Jun Wei Pek
Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological significance of stem cell heterogeneity is not well understood. We show that, in Drosophila, female germline stem cells (GSCs) exhibit heterogeneous expression of a GSC differentiation-promoting factor Regena (Rga). The Drosophila homolog of human SON, dsn, is required to maintain GSC heterogeneity by suppressing sustained high levels of Rga. Reducing the expression of Rga in dsn mutants restores GSC heterogeneity and self-renewal...
May 29, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29884852/haematopoietic-stem-cell-transplant-for-hyper-igm-syndrome-due-to-cd40-defects-a-single-centre-experience
#5
B Al-Saud, M Al-Jomaie, A Al-Ghonaium, A Al-Ahmari, H Al-Mousa, S Al-Muhsen, A Al-Seraihy, R Arnaout, S Elshorbagi, H Al-Dhekri, M Ayas
Hyper-IgM syndrome due to CD40 deficiency (HIGM3) is a rare disease with only a few reported cases of haematopoietic stem cell transplantation (HSCT). In retrospective study, we reviewed all patients with HIGM3 who underwent HSCT at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between 2008 and 2013. Six patients were identified. Three male and three female patients from three families. The median age of diagnosis was 13 months (range, 1-28 months). All lacked CD40 expression on B cells by flow cytometry...
June 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29884747/maintenance-of-proper-germline-stem-cell-number-requires-adipocyte-collagen-in-adult-drosophila-females
#6
Lesley N Weaver, Daniela Drummond-Barbosa
Stem cells reside in specialized niches and are regulated by a variety of physiological inputs. Adipocytes influence whole-body physiology and stem cell lineages; however, the molecular mechanisms linking adipocytes to stem cells are poorly understood. Here, we report that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through β-integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs...
June 8, 2018: Genetics
https://www.readbyqxmd.com/read/29883505/an-mri-analysis-of-the-pelvis-to-determine-the-ideal-method-for-ultrasound-guided-bone-marrow-aspiration-from-the-iliac-crest
#7
Alan M Hirahara, Alberto Panero, Wyatt J Andersen
Use of mesenchymal stem cells from bone marrow has gained significant popularity. The iliac crest has been determined to be an effective site for harvesting mesenchymal stem cells. Review of the literature reveals that multiple techniques are used to harvest bone marrow aspirate from the iliac crest, but the descriptions are based on the experience of various authors as opposed to studied anatomy. A safe, reliable, and reproducible method for aspiration has yet to be studied and described. We hypothesized that there would be an ideal angle and distance for aspiration that would be the safest, most consistent, and most reliable...
May 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29882687/gender-and-age-related-cell-compositional-differences-in-c57bl-6-murine-adipose-tissue-stromal-vascular-fraction
#8
Trivia Frazier, Stephen Lee, Annie Bowles, Julie Semon, Bruce Bunnell, Xiying Wu, Jeffrey Gimble
Adipose tissue is now recognized as a functional organ that contains cellular heterogeneity and diversity within anatomical depots. The stromal vascular fraction (SVF) of adipose contains endothelial progenitors, fibroblasts, lymphocytes, monocyte/macrophages, pericytes, pre-adipocytes, and stromal/stem cells, among others. In recent years, there has been a growing appreciation of the influence of age and gender in the field of stem cell biology. Yet few studies have evaluated the influence of biological age or sex on either SVF cell heterogeneity or immunophenotype...
June 8, 2018: Adipocyte
https://www.readbyqxmd.com/read/29882232/utility-of-tissue-elafin-as-an-immunohistochemical-marker-for-diagnosis-of-acute-skin-graft-versus-host-disease-a-pilot-study
#9
G D Mahabal, L George, D Peter, M Bindra, M Thomas, A Srivastava, V Mathews, B George, S A Pulimood
BACKGROUND: The skin is the most common organ involved in acute graft-versus-host disease (GvHD). Because histopathology has limited utility in ruling out clinical mimics of acute skin GvHD, more accurate diagnostic techniques are required. AIM: To evaluate the utility of elafin expression in skin by immunohistochemistry (IHC) for accurate diagnosis of acute skin GvHD. METHODS: Consecutive allogeneic haematopoietic stem cell transplant (HSCT) recipients during a 6-month period who developed rash within the first 100 days post-transplant were recruited...
June 7, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29877232/-ovum-collection-following-ovarian-stimulation-in-patients-with-chronic-active-epstein-barr-virus-infection
#10
Erika Onozawa, Tomonori Ishikawa, Yasuhiro Tomaru, Norio Shimizu, Ayako Arai
The only curative treatment for chronic active Epstein-Barr virus infection (CAEBV) is hematopoietic stem cell transplantation. For young female patients, ovulation induction and oocyte cryopreservation may be performed prior to transplantation to provide for future pregnancies. However, the effects of this ovum treatment on CAEBV and EBV infections have not been reported. Attempts were made to collect ova from three female CAEBV patients before transplantation conditioning, but this was only successful in two cases...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29869673/long-term-outcomes-of-total-body-irradiation-plus-cyclophosphamide-versus-busulfan-plus-cyclophosphamide-as-conditioning-regimen-for-acute-lymphoblastic-leukemia-a-comparative-study
#11
Ioanna Sakellari, Eleni Gavriilaki, Konstantinos Chatziioannou, Maria Papathanasiou, Despina Mallouri, Ioannis Batsis, Zoi Bousiou, Stella Bouziana, Varnavas Constantinou, Vassiliki Douka, Chrysa Apostolou, Michalis Iskas, Chrysavgi Lalayanni, Anastasia Athanasiadou, Damianos Sotiropoulos, Evangelia Yannaki, Vasilis Gianouzakos, Achilles Anagnostopoulos
The role of total body irradiation (TBI) in allogeneic hematopoietic stem cell transplantation (HCT) for adult acute lymphoblastic leukemia (ALL) remains controversial. Therefore, we investigated long-term treatment outcomes of transplanted ALL patients aiming to identify prognostic factors and the impact of conditioning. We enrolled consecutive ALL patients transplanted from 1990 to 2016, following TBI- or busulfan (Bu)-based conditioning regimen. We studied 151 ALL patients transplanted in first complete remission (CR) (60), other CR (33), or relapsed/refractory disease (58) from sibling (87), and HLA-matched (42) or mismatched (17) unrelated and alternative donors (5)...
June 5, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29862097/timing-embryo-preservation-for-a-patient-with-high-risk-newly-diagnosed-acute-myeloid-leukemia
#12
Rebecca Ye, Benjamin Tomlinson, Marcos de Lima, Ehsan Malek
Great strides have been made in the treatment of acute myeloid leukemia (AML) resulting in increased number of survivors over all age groups, but especially in patients of reproductive age. Given the gonadotoxicity of high-dose induction chemotherapy and subsequent allogeneic stem cell transplant, it is paramount that fertility preservation options are discussed and explored at the time of diagnosis as fertility preservation has been associated with greater quality of life in survivors. Starting the conversation early is especially important for female patients given the time needed for all currently available fertility preservation techniques...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29861859/epigenetic-reprogramming-by-na%C3%A3-ve-conditions-establishes-an-irreversible-state-of-partial-x-chromosome-reactivation-in-female-stem-cells
#13
Alexandra V Panova, Alexandra N Bogomazova, Maria A Lagarkova, Sergey L Kiselev
Female human pluripotent stem cells (PSCs) have variable X-chromosome inactivation (XCI) status. One of the X chromosomes may either be inactive (Xi) or display some active state markers. Long-term cultivation of PSCs may lead to an erosion of XCI and partial X reactivation. Such heterogeneity and instability of XCI status might hamper the application of human female PSCs for therapy or disease modeling. We attempted to address XCI heterogeneity by reprogramming human embryonic stem cells (hESCs) to the naïve state...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29861704/molecular-and-cellular-pathogenesis-of-endometriosis
#14
REVIEW
Petra A B Klemmt, Anna Starzinski-Powitz
Background: A substantial body of studies supports the view that molecular and cellular features of endometriotic lesions differ from those of eutopic endometrium. Apart from that, evidence exists that the eutopic endometrium from pa-tients with endometriosis differs from that of females without endometriosis. Objective: Aberrant expression profiles include a number of non-steroid signaling pathways that exert their putative influ-ence on the pathogenesis of endometriosis at least in part via crosstalk(s) with estrogen-mediated mechanisms...
June 2018: Current Women's Health Reviews
https://www.readbyqxmd.com/read/29860300/retinoid-x-receptor-activation-during-adipogenesis-of-female-mesenchymal-stem-cells-programs-a-dysfunctional-adipocyte
#15
Bassem M Shoucri, Victor T Hung, Raquel Chamorro-García, Toshi Shioda, Bruce Blumberg
Early life exposure to endocrine disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and diabetes later in life. We previously showed that prenatal exposure to the EDC tributyltin (TBT) results in increased adiposity in the offspring. These effects linger into adulthood and are propagated through successive generations. TBT activates two nuclear receptors, the peroxisome proliferator-activated receptor γ (PPARγ) and its heterodimeric partner retinoid X receptor (RXR), that promote adipogenesis in vivo and in vitro...
May 31, 2018: Endocrinology
https://www.readbyqxmd.com/read/29852467/derivation-of-an-induced-pluripotent-stem-cell-line-musii004-a-from-dermal-fibroblasts-of-a-48-year-old-spinocerebellar-ataxia-type-3-patient
#16
Alisa Ritthaphai, Methichit Wattanapanitch, Manop Pithukpakorn, Worapa Heepchantree, Rungtip Soi-Ampornkul, Panchalee Mahaisavariya, Daranporn Triwongwaranat, Kovit Pattanapanyasat, Chinnavuth Vatanashevanopakorn
Dermal fibroblasts were obtained from a 48-year-old female patient with spinocerebellar ataxia type 3 (SCA3). Fibroblasts were reprogrammed by nucleofection with episomal plasmids, carrying L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1 and shRNA against p53. The SCA3 patient-specific iPSC line, MUSIi004-A, was characterized by immunofluorescence staining to verify the expression of pluripotent markers. The iPSC line exhibited an ability to differentiate into three germ layers by embryoid body (EB) formation. Karyotypic analysis of the MUSIi004-A line was normal...
May 21, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29849920/longevity-related-gene-transcriptomic-signature-in-glioblastoma-multiforme
#17
Manal S Fawzy, Dahlia I Badran, Essam Al Ageeli, Saeed Awad M Al-Qahtani, Saleh Ali Alghamdi, Ghada M Helal, Eman A Toraih
Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2 , OCT3/4 , and NANOG to evaluate their diagnostic and performance values in high-grade gliomas...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29846284/therapeutic-progestin-segesterone-acetate-promotes-neurogenesis-implications-for-sustaining-regeneration-in-female-brain
#18
Shuhua Chen, Narender Kumar, Zisu Mao, Regine Sitruk-Ware, Roberta Diaz Brinton
OBJECTIVE: Neurogenesis is the principal regenerative mechanism to sustain the plasticity potential in adult brains. Decreased neurogenesis parallels the cognition decline with aging, and has been suggested as a common hallmark in the progression of many neurodegeneration diseases. We previously reported that acute exposure to segesterone acetate (ST-1435; Nestorone), alone or in combination with 17β-estradiol (E2), increased human neural stem cells proliferation and survival both in vitro and in vivo...
May 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29845800/attitude-of-a-sample-of-iranian-researchers-toward-the-future-of-stem-cell-research
#19
Mahdi Lotfipanah, Fereydoon Azadeh, Mehdi Totonchi, Reza Omani-Samani
Objective: Stem cells that have unlimited proliferation potential as well as differentiation potency are considered to be a promising future treatment method for incurable diseases. The aim of the present study is to evaluate the future trend of stem cell researches from researchers' viewpoints. Materials and Methods: This was a cross-sectional descriptive study on researchers involved in stem cell research at Royan Institute. We designed a questionnaire using a qualitative study based on expert opinion and a literature review...
October 2018: Cell Journal
https://www.readbyqxmd.com/read/29844633/therapeutic-potential-effect-of-bone-marrow-derived-mesenchymal-stem-cells-on-chronic-liver-disease-in-murine-schistosomiasis-mansoni
#20
Mohamed H Hegab, Somia H Abd-Allah, Maha S Badawey, Ayman A Saleh, Ashraf S Metwally, Ghada M Fathy, Soad M Nada, Sara A Abdel-Rahman, Amira A Saleh, Amal Fawzy, Mohammed Abu El-Magd
Some reports have shown that mesenchymal stem cells (MSCs) therapy could ameliorate chemically-induced hepatic fibrosis. This research assesses the therapeutic action of bone marrow mesenchymal stem cells (BM-MSCs) on chronic diseased liver in Schistosoma mansoni infected mice. All infected female mice divided into three groups, one group (15 mice) treated with oral praziquantel (PZQ), second group (15 mice) received intravenous injection of BM-MSCs and third group (15 mice) treated with both MSCs + PZQ...
June 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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