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https://www.readbyqxmd.com/read/29119214/safety-and-efficacy-of-radiofrequency-catheter-ablation-for-tachyarrhythmia-in-children-weighing-less-than-10%C3%A2-kg
#1
Noriyasu Ozaki, Yoshihide Nakamura, Tsugutoshi Suzuki, Jun Yoshimoto, Keiko Toyohara, Hitoo Fukuhara, Hiroshi Katayama, Kanta Kishi, Yutaka Odanaka, Hiroshi Tamai
An increasing number of children are undergoing radiofrequency catheter ablation (RFCA) for tachyarrhythmia. However, infants and toddlers undergoing RFCA are often resistant to medication or need to eliminate arrhythmia substrate, and the risks of RFCA complications are still high in infants and toddlers. From April 2008 and December 2016, 285 children who underwent radiofrequency catheter ablation (RFCA) were stratified according to body weight (group A, less than 10 kg, n = 22; group B, over 10 kg, n = 263) and the clinical features of RFCA were retrospectively reviewed in these groups...
November 8, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29110290/relationship-between-left-ventricular-dyssynchrony-and-scar-burden-in-the-genesis-of-ventricular-tachyarrhythmia
#2
Saurabh Malhotra, Deepak K Pasupula, Ravi K Sharma, Samir Saba, Prem Soman
BACKGROUND: Left ventricular (LV) ejection fraction (EF) has poor predictive value for ventricular tachyarrhythmia (VT). Other parameters such as LV dyssynchrony (LVD), and LV scar burden have also been individually associated with VT, but the interplay of these factors in the genesis of VT has not been explored. This retrospective study sought to evaluate the relationship between LVD and imaging characteristics of the myocardial substrate in predicting VT. METHODS: We identified 183 patients (150 men; mean age: 64 ± 14 years and mean LVEF: 23% ± 7%), who received an implantable cardioverter defibrillator (ICD) for primary prevention and who underwent a gated single-photon emission computed tomography (GSPECT) myocardial perfusion scan prior to ICD implantation...
November 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29103053/domperidone-for-hypotension-in-parkinson-s-disease-a-systematic-review
#3
Stephen Bacchi, Ivana Chim, Philippe Kramer, Ronald B Postuma
BACKGROUND: Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD). However, domperidone use in PD is tempered by concerns regarding QT prolongation and ventricular tachyarrhythmia and sudden cardiac death (VT/SCD). OBJECTIVE: The aim is to identify peer-reviewed studies in which either (1) the effect of domperidone on blood pressure in patients with PD, or (2) the adverse effects associated with domperidone use in PD patients has been reported...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29102650/safety-and-feasibility-of-atrial-fibrillation-ablation-using-amigo-%C3%A2-system-versus-manual-approach-a-pilot-study
#4
Antonio Scarà, Luigi Sciarra, Ermenegildo De Ruvo, Alessio Borrelli, Domenico Grieco, Zefferino Palamà, Paolo Golia, Lucia De Luca, Marco Rebecchi, Leonardo Calò
BACKGROUND: The Amigo(®) Remote Catheter System is a relatively new robotic system for catheter navigation. This study compared feasibility and safety using Amigo (RCM) versus manual catheter manipulation (MCM) to treat paroxysmal atrial fibrillation (PAF). Contact force (CF) and force-time integral (FTI) values obtained during pulmonary vein isolation (PVI) ablation were compared. METHODS: Forty patients were randomly selected for either RCM (20) or MCM (20). All were studied with the Thermocool(®) SmartTouch(®) force-sensing catheter (STc)...
November 1, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29100590/anemia-and-the-risk-of-life-threatening-ventricular-tachyarrhythmias-from-the-israeli-implantable-cardioverter-defibrillator-registry
#5
Ido Goldenberg, Alon Barsheshet, Avishag Laish-Farkash, Moshe Swissa, Jorge E Schliamser, Yoav Michowitz, Michael Glikson, Mahmoud Suleiman
Anemia was shown to be associated with increased risk for adverse events in patients with heart failure (HF). However, there are limited data on the association between anemia and the risk for ventricular arrhythmias (VAs) in patients with an implantable cardioverter defibrillator (ICD). The present study population comprised 2,352 patients who were enrolled and prospectively followed up in the Israeli ICD Registry. The risk for a first appropriate ICD shock for VA was assessed by the presence of anemia, categorized at the lower tertile of hemoglobin distribution (≤12 g/dL [n = 753])...
October 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29092973/landiolol-is-effective-for-the-treatment-of-tachycardia-induced-cardiogenic-shock-in-patients-during-septic-shock-therapy
#6
Yoh Arita, Takatsugu Segawa, Shohei Yamamoto, Shinji Hasegawa
Septic shock is a life-threatening condition that occurs when the blood pressure drops to a low level after an infection. Atrial fibrillation (AF) is the most common arrhythmia to complicate its course. Beta (β)-blockers are often administrated to manage supraventricular tachyarrhythmias observed in patients presenting with sepsis. A 74-year-old woman presenting with sepsis demonstrated AF tachycardia characterised by severe hypotension. She was refractory to conventional therapy including verapamil and digoxin; therefore, treatment using landiolol (an ultrashort-acting β-blocker) was initiated...
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29092036/antegrade-transseptal-approach-for-left-ventricular-tachyarrhythmia-in-patients-with-previous-mitraclip-implantation
#7
Kentaro Hayashi, Christian-H Heeger, Shibu Mathew, Tilman Maurer, Christine Lemes, Johannes Riedl, Bruno Reißmann, Christian Frerker, Stephan Geidel, Michael Schmoeckel, Ardan M Saguner, Francesco Santoro, Roland Richard Tilz, Andreas Metzner, Karl-Heinz Kuck, Feifan Ouyang
Aims: Antegrade-transseptal approach to treat left ventricular tachyarrhythmia (LVT) is useful and widespread. Meanwhile, Mitraclip has been recently introduced as an alternative to mitral valve surgery for severe mitral regurgitation, usually coexisting with ventricular arrhythmias. However, data on the antegrade approach for mapping and ablating LVT in these patients are insufficient. We evaluated the feasibility and clinical impact of the antegrade approach for LVT after Mitraclip implantation...
October 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29080865/dysfunction-of-myosin-light-chain-4-myl4-leads-to-heritable-atrial-cardiomyopathy-with-electrical-contractile-and-structural-components-evidence-from-genetically-engineered-rats
#8
Wenhui Peng, Miaoxin Li, Hailing Li, Kai Tang, Jianhui Zhuang, Jianguo Zhang, Jingjing Xiao, Hui Jiang, Dali Li, Yongchun Yu, Pak C Sham, Stanley Nattel, Yawei Xu
BACKGROUND: There is increasing interest in the concept of atrial cardiomyopathy, but the underlying molecular and mechanistic determinants remain poorly defined. We identified a family with heritable atrial cardiomyopathy manifesting as progressive atrial-selective electromechanical dysfunction, tachyarrhythmias, and bradyarrhythmias requiring pacemaker implantation. Myosin light-chain 4 (MYL4), encoding the atrial-selective essential myosin light chain, was identified as a candidate gene...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29079077/non-ion-channel-therapeutics-for-heart-failure-and-atrial-fibrillation-are-camkii-inhibitors-ready-for-clinical-use-editorial-on-neef-s-steffens-a-pellicena-p-mustroph-j-lebek-s-ort-kr-schulman-h-maier-ls-improvement-of-cardiomyocyte-function-by-a-novel-pyrimidine
#9
EDITORIAL
Eleonora Grandi, Dobromir Dobrev
The Ca(2+)-calmodulin dependent protein kinase II (CaMKII) is an established central mediator of electrophysiological and contractile responses to cardiac stress, and its hyper-activation in cardiac diseases has been linked to heart failure (HF) and atrial and ventricular arrhythmias. Here we summarize the evidence supporting the role of CaMKII as a critical nodal point for therapeutic intervention against HF and atrial and ventricular tachyarrhythmias. Targeting of CaMKII in heart with inhibitors possessing appropriate selectivity might represent a novel therapeutic approach for HF and arrhythmias...
October 24, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29072994/aborted-sudden-cardiac-death-in-a-patient-with-implantable-loop-recorder
#10
Mohammad Alasti, Kunal Verma, Karthikeyan Rangasamy, Stewart Healy, Emily Kotschet
We discuss a 46-year-old man with history of hypertension and inferior wall myocardial infarction and mild left ventricular dysfunction who presented with aborted sudden cardiac death due to episodes of ventricular tachyarrhythmia detected by a Reveal-LINQ which had been implanted one year prior to presentation.
March 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29070501/the-centers-for-medicare-and-medicaid-services-decision-to-reconsider-coverage-indications-for-icds-where-to-now
#11
Sana M Al-Khatib, Anne M Gillis, Anne B Curtis
Several well-designed and conducted randomized clinical trials (RCTs) have proven the survival benefit of implantable cardioverter defibrillators (ICDs). This benefit has been demonstrated in patients who survive a cardiac arrest due to a ventricular tachyarrhythmia or have sustained ventricular tachycardia not due to a transient or a reversible cause. The survival benefit of ICDs has also been shown in patients with significant systolic dysfunction (left ventricular ejection fraction (LVEF) ≤35%) due to ischemic or non-ischemic cardiomyopathy...
October 25, 2017: Circulation
https://www.readbyqxmd.com/read/29068909/contemporary-postnatal-incidence-of-acquiring-acute-myocarditis-by-age-15-years-and-the-outcomes-from-a-nationwide-birth-cohort
#12
Mei-Hwan Wu, En-Ting Wu, Ching-Chia Wang, Frank Lu, Hui-Chi Chen, Feng-Yu Kao, San-Kuei Huang
OBJECTIVES: Acute myocarditis can be lethal, but the incidence remains unclear because of its wide manifestation spectrum. We investigated the postnatal incidence of acute myocarditis and risk factors for morbidity and mortality. DESIGN: Retrospective derived birth cohort study. SETTING: Taiwan National Health Insurance Database for the period 2000-2014. PATIENTS: Children born between 2000 and 2009 with complete postnatal medical care data for at least 5 years...
October 24, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29068369/arrhythmia-evaluation-in-wearable-ecg-devices
#13
Muammar Sadrawi, Chien-Hung Lin, Yin-Tsong Lin, Yita Hsieh, Chia-Chun Kuo, Jen Chien Chien, Koichi Haraikawa, Maysam F Abbod, Jiann-Shing Shieh
This study evaluates four databases from PhysioNet: The American Heart Association database (AHADB), Creighton University Ventricular Tachyarrhythmia database (CUDB), MIT-BIH Arrhythmia database (MITDB), and MIT-BIH Noise Stress Test database (NSTDB). The ANSI/AAMI EC57:2012 is used for the evaluation of the algorithms for the supraventricular ectopic beat (SVEB), ventricular ectopic beat (VEB), atrial fibrillation (AF), and ventricular fibrillation (VF) via the evaluation of the sensitivity, positive predictivity and false positive rate...
October 25, 2017: Sensors
https://www.readbyqxmd.com/read/29068108/evaluation-of-sustained-tachyarrhythmia-in-children-younger-than-one-year-of-age
#14
Gulhan Tunca Sahin, Erkut Ozturk, Taner Kasar, Alper Guzeltas, Yakup Ergul
BACKGROUND: In this study, we aim to evaluate the results of non-operational sustained tachyarrhythmias in patients younger than 1 year of age in our center. METHODS: Between November 2010 and November 2016, the demographic characteristics, type and localization of the tachyarrhythmia, echocardiographic findings, and medical and/or ablation therapies applied for patients under 1 year of age who had sustained tachyarrhythmias were evaluated. RESULTS: Among 99 patients, 91 had sustained supraventricular tachycardia, and eight had sustained ventricular tachycardia...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29063180/serum-lipid-feature-and-potential-biomarkers-of-lethal-ventricular-tachyarrhythmia-lvta-induced-by-myocardial-ion-channel-diseases-a-rat-model-study
#15
Jiayan Wu, Qian Wu, WenTao Dai, Jing Kong, Junyao Lv, Xiaojun Yu, Xingxing Wang, Dian Wang
To determine the cause of death in myocardial ion channel diseases (MICD)-induced sudden cardiac death (SCD) cases is a difficulty in forensic identification practices. The majority of MICD-induced SCD cases would experience lethal ventricular tachyarrhythmia (LVTA) before deaths; thus, confirming the occurrence of LVTA in bodies can offer a key evidence to identify these cases. Several lipids in the myocardia were found disturbed after LVTA; yet, whether serum lipidome would be disrupted by LVTA is not clear...
October 23, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29061061/metabolic-disturbances-induce-malignant-heart-arrhythmias-in-rats
#16
B Liptak, V Knezl, Z Gasparova
OBJECTIVES: Metabolic disturbances are considered to condition the occurrence of malignant heart arrhythmias and negatively influence the chances of a patient to survive. To test this assumption, a model of metabolic syndrome was selected in which rats were receiving a diet resembling that of the westernized population. BACKGROUND: Metabolic syndrome is a comorbidity of major cardiovascular risk factors (dyslipidemia, hypertension, impaired glucose tolerance or insulin resistance, diabetes mellitus, and obesity), all facilitating cardiovascular complications leading to morbidity and mortality of patients...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29058590/left-ventricular-geometry-predicts-ventricular-tachyarrhythmia-in-patients-with-left-ventricular-systolic-dysfunction-a-comprehensive-cardiovascular-magnetic-resonance-study
#17
Shiro Nakamori, Haisam Ismail, Long H Ngo, Warren J Manning, Reza Nezafat
BACKGROUND: Most patients with implantable cardioverter-defibrillator (ICD) implantation fail to utilize the device resulting in increasing societal costs and patient exposure to device morbidity. We sought to determine whether volumetric cardiovascular magnetic resonance (CMR) left ventricular (LV) spherical remodeling predicts future ventricular arrhythmias in primary ICD patients with reduced LV ejection fraction (EF). METHODS: Sixty-eight consecutive patients with transthoracic echocardiographic LVEF <35% referred for CMR prior to ICD implantation for primary prevention of sudden death were identified...
October 23, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29057872/modelling-torsade-de-pointes-arrhythmias-in-vitro-in-3d-human-ips-cell-engineered-heart-tissue
#18
Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K Yamashita
Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug sensitivity of human cardiac tissue. Here, we present an in vitro TdP model using 3D cardiac tissue sheets (CTSs) that contain a mixture of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and non-myocytes. We simultaneously monitor the extracellular field potential (EFP) and the contractile movement of the CTSs. Upon treatment with IKr channel blockers, CTSs exhibit tachyarrhythmias with characteristics of TdP, including both a typical polymorphic EFP and meandering spiral wave re-entry...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29057449/efficacy-and-tolerability-of-mexiletine-treatment-in-patients-with-recurrent-ventricular-tachyarrhythmias-and-implantable-cardioverter-defibrillator-shocks
#19
Marcin Sobiech, Michał Lewandowski, Dariusz Zając, Aleksander Maciąg, Paweł Syska, Joanna Ateńska-Pawłowska, Ilona Kowalik, Maciej Sterliński, Hanna Szwed, Mariusz Pytkowski
BACKGROUND: Antiarrhythmic treatment of patients with recurrent ventricular tachyarrhythmia, in whom catheter ablation and amiodarone treatment were ineffective or contraindicated, is an unsolved clinical problem. AIM: The study aims to evaluate the efficacy and tolerability of mexiletine in patients with recurrent ventricular tachyarrhythmias and/or electrical storm events, in whom standard treatment strategies failed to prevent ventricular tachyarrhythmia. METHODS: We performed a retrospective cohort analysis of all patients treated with mexiletine for recurrent ventricular tachycardia and/or ventricular fibrillation in our institution between January 2011 and September 2015...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29057442/-subcutaneous-implantable-cardioverter-defibrillator-in-prevention-of-sudden-cardiac-death-in-poland-opinion-paper-endorsed-by-the-polish-cardiac-society-working-group-on-heart-rhythm
#20
Paweł Ptaszyński, Marcin Grabowski, Oskar Kowalski, Maciej Kempa, Przemysław Mitkowski, Andrzej Przybylski, Maciej Sterliński
In the past years, cardiovascular mortality has decreased but despite these cardiovascular diseases are responsible for millions of deaths every year in the world and approximately 25% of which are sudden cardiac death (SCD). Implantable defibrillators (ICD) is proven therapy used in primary and secondary SCD prevention. Currently majority of devices use transvenous leads inserted predominantly into the right heart for both pacing and defibrillation. On the other hand, ICD may cause complica-tions, including inappropriate shocks, device-related infection and lead failure...
2017: Kardiologia Polska
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