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MicroRNA 10b

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https://www.readbyqxmd.com/read/29125963/a-capillary-electrophoresis-method-for-identifying-forensically-relevant-body-fluids-using-mirnas
#1
Carrie Mayes, Sarah Seashols-Williams, Sheree Hughes-Stamm
Body fluid identification (BFID) can provide crucial information during the course of an investigation. In recent years, microRNAs (miRNAs) have shown considerable body fluid specificity, are able to be co-extracted with DNA, and their small size (18-25 nucleotides) make them ideal for analyzing highly degraded forensic samples. In this study, we designed a preliminary 8-marker system for BFID including an endogenous reference gene (let-7g) to differentiate between venous blood (miR-451a and miR-142-3p), menstrual blood (miR-141-3p and miR-412-3p), semen (miR-891a and miR-10b), and saliva (miR-205) using a capillary electrophoresis approach...
October 31, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29113216/microrna-10b-expression-in-node-negative-breast-cancer-correlation-with-metastasis-and-angiogenesis
#2
Xia Liu, Yong Guan, Li Wang, Yun Niu
Metastasis accounts for the majority of cases of mortality in patients with axillary lymph node-negative (ANN) breast cancer. Angiogenesis is an essential component of the metastatic pathway. Studies regarding microRNA (miR)-10b expression in patients with ANN breast cancer and the function of angiogenesis in breast cancer remain scarce. The present study was performed in order to determine the biological significance of miR-10b, and investigate the association between miR-10b and microvessel density (MVD) measured in ANN breast cancer...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29084369/bleomycin-can-cleave-an-oncogenic-non-coding-rna
#3
Matthew Disney, Alicia Angelbello
Non-coding RNAs are pervasive in cells and contribute to diseases such as cancer. A question in biomedical research is if non-coding RNAs are targets of medicines. Bleomycin is a natural product that cleaves DNA, however, it is known to cleave RNA in vitro. Herein, an in-depth analysis of the RNA cleavage preferences of bleomycin A5 is presented. Bleomycin A5 prefers to cleave RNAs with stretches of AU base pairs. Based on these preferences and a bioinformatic analysis, the microRNA10b hairpin precursor was identified as a potential substrate for bleomycin A5...
October 30, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29069873/prognostic-value-of-microrna-expression-levels-in-pancreatic-adenocarcinoma-a-review-of-the-literature
#4
REVIEW
Patrick Wald, X Shawn Liu, Cory Pettit, Mary Dillhoff, Andrei Manilchuk, Carl Schmidt, Evan Wuthrick, Wei Chen, Terence M Williams
BACKGROUND: Clinical and pathologic markers of prognosis and patterns of failure help guide clinicians in selecting patients for adjuvant therapy after surgical resection for pancreatic adenocarcinoma (PDAC). Recent studies have reported the prognostic utility of microRNA profiling in numerous malignancies. Here, we review and summarize the current literature regarding associations between microRNA expression and overall survival in PDAC patients. MATERIALS AND METHODS: We conducted a systematic search in the PubMed database to identify all primary research studies reporting prognostic associations between tumor and/or serum microRNA expression and overall survival in PDAC patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29023075/evaluation-of-mir-21-and-mir-10b-expression-of-human-breast-cancer-in-west-sumatera
#5
Yanwirasti, Wirsma A Harahap, Dessy Arisanty
BACKGROUND: Abnormal expression of several microRNAs (miRNAs) has been demonstrated in many types of cancer tumor tissue. The miR-10b and miR-21 are an oncogenic miRNAs which play role in proliferation and invasion of Breast Cancer (BC) tumorigenesis. The aim of this study was to evaluate the miR-21 and miR-10b expression in BC in West Sumatran women, Indonesia. MATERIALS AND METHODS: A total of 40 samples, consisting of 30 samples of breast cancer tissues (BC) and 10 samples of fibroadenoma tissues (FATs) as control and non-cancerous were analyzed...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28989695/simultaneous-visualization-of-the-subfemtomolar-expression-of-microrna-and-microrna-target-gene-using-hilo-microscopy
#6
Yi-Zhen Lin, Da-Liang Ou, Hsin-Yuan Chang, Wei-Yu Lin, Chiun Hsu, Po-Ling Chang
The family of microRNAs (miRNAs) not only plays an important role in gene regulation but is also useful for the diagnosis of diseases. A reliable method with high sensitivity may allow researchers to detect slight fluctuations in ultra-trace amounts of miRNA. In this study, we propose a sensitive imaging method for the direct probing of miR-10b (miR-10b-3p, also called miR-10b*) and its target (HOXD10 mRNA) in fixed cells based on the specific recognition of molecular beacons combined with highly inclined and laminated optical sheet (HILO) fluorescence microscopy...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28979765/micrornas-in-the-development-and-neoplasia-of-the-mammary-gland
#7
REVIEW
Manoj Kumar Jena
Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation...
2017: F1000Research
https://www.readbyqxmd.com/read/28900502/a-bap1-mutation-specific-microrna-signature-predicts-clinical-outcomes-in-clear-cell-renal-cell-carcinoma-patients-with-wild-type-bap1
#8
Yu-Zheng Ge, Lu-Wei Xu, Chang-Cheng Zhou, Tian-Ze Lu, Wen-Tao Yao, Ran Wu, You-Cai Zhao, Xiao Xu, Zhi-Kai Hu, Min Wang, Xiao-Bing Yang, Liu-Hua Zhou, Bing Zhong, Zheng Xu, Wen-Cheng Li, Jia-Geng Zhu, Rui-Peng Jia
Background: Clear cell renal cell carcinoma (ccRCC) is the most prevalent histologic subtype of kidney cancers in adults, which could be divided into two distinct subgroups according to the BRCA1 associated protein-1 (BAP1) mutation status. In the current study, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in ccRCC, with the aim to identify the differentially expressed miRNAs between BAP1 mutant and wild-type tumors, and generate a BAP1 mutation-specific miRNA signature for ccRCC patients with wild-type BAP1...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28900486/upregulation-of-serum-mir-10b-is-associated-with-poor-prognosis-in-patients-with-melanoma
#9
Ming Bai, Hailin Zhang, Loubin Si, Nanze Yu, Ang Zeng, Ru Zhao
Aberrant expression of microRNAs (miRNAs) are believed to play a central role in the initiation and development of cancer. The aim of our study was to determine the clinical significance of serum miR-10b in melanoma. A total of 85 and 30 serum samples were obtained from patients with melanoma and healthy volunteers respectively. qRT-PCR was performed to evaluate the expression level of miR-10b in the melanoma cell lines and the serum samples from the participants. Then the clinical significance of serum miR-10b was further determined...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28864233/microrna-10b-and-the-clinical-outcomes-of-various-cancers-a-systematic-review-and-meta-analysis
#10
REVIEW
Qiangxin Huang, Qian Song, Weixian Zhong, Yalan Chen, Ludong Liang
BACKGROUND: The impact of miR-10b expression on the survival outcome of patients with cancers is still controversial. METHOD AND MATERIALS: A systematic review and meta-analysis was performed to determine its implication on the survival of cancer patients. We carried out an electrical literature search to identify the eligible studies published in PubMed, Web of Science and Embase together with the Chinese databases. RESULT: In total, 28 studies of 23 articles enrolling 3134 patients were included for this meta-analysis, of which 25 studies reported overall survival (OS), 4 studies evaluated recurrence-free survival (RFS) and 3 studies were related to disease-free survival (DFS)...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28840962/biomarkers-and-therapeutic-advances-in-glioblastoma-multiforme
#11
Andrew Octavian Sasmita, Ying Pei Wong, Anna Pick Kiong Ling
Glioblastoma multiforme (GBM) is a malignant tumor within the brain. Generally classified as primary and secondary with several different subtypes, ample molecular biomarkers have risen throughout the years which have garnered the attention of researchers. The advancements in genomics and proteomics have allowed researchers to gather prominent molecular biomarkers. All these biomarkers are gathered by means of biopsy or bodily fluid sample collection and are quantitatively analyzed by polymerase chain reaction coupled with other computational technologies...
August 25, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28816269/-microrna-differential-expression-profile-in-tuberous-sclerosis-complex-cell-line-tsc2-mefs-and-normal-cell-line-tsc2-mefs
#12
Y Cai, H Guo, H Z Li, W D Wang, Y S Zhang
OBJECTIVE: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by mutations in the TSC1 and TSC2 genes, but the molecular events contributing to TSC are not well understood. However, little is known about the role of microRNAs in TSC. To explore the microRNA differential expression profile between tuberous sclerosis complex cell line TSC2(-/-) MEFs and normal type cell line TSC2(+/+) MEFs, and to provide new clues to study the mechanism of microRNA function in tuberous sclerosis complex...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28797712/estrogen-receptor-beta-as-epigenetic-mediator-of-mir-10b-and-mir-145-in-mammary-cancer
#13
Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K Karamanos
Even though the role of estrogen receptor alpha (ERα) in the modulation of breast cancer cells' behavior is thoroughly studied, the biological functions of its isoform, ERβ, are less elucidated. The suppression of ERβ in the aggressive ERα-negative MDA-MB-231 breast cancer cells resulted in the inhibition of epithelial to mesenchymal transition (EMT) and major changes in the basic functional properties and expression levels of certain matrix components of breast cancer cells. This arrest in metastatic potential of breast cancer cells suggests the contribution of ERβ in the induction of a more aggressive phenotype in MDA-MB-231 breast cancer cells...
August 8, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28793339/modeling-mirna-mrna-interactions-that-cause-phenotypic-abnormality-in-breast-cancer-patients
#14
Sanghoon Lee, Xia Jiang
BACKGROUND: The dysregulation of microRNAs (miRNAs) alters expression level of pro-oncogenic or tumor suppressive mRNAs in breast cancer, and in the long run, causes multiple biological abnormalities. Identification of such interactions of miRNA-mRNA requires integrative analysis of miRNA-mRNA expression profile data. However, current approaches have limitations to consider the regulatory relationship between miRNAs and mRNAs and to implicate the relationship with phenotypic abnormality and cancer pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28736700/profiling-and-characterization-of-a-longissimus-dorsi-muscle-microrna-dataset-from-an-f2-duroc%C3%A2-%C3%A3-%C3%A2-pietrain-pig-resource-population
#15
Kaitlyn R Daza, Juan P Steibel, Deborah Velez-Irizarry, Nancy E Raney, Ronald O Bates, Catherine W Ernst
To elucidate the effects of microRNA (miRNA) regulation in skeletal muscle of adult pigs, miRNA expression profiling was performed with RNA extracted from longissimus dorsi (LD) muscle samples from 174 F2 pigs (~ 5.5 months of age) from a Duroc × Pietrain resource population. Total RNA was extracted from LD samples, and libraries were sequenced on an Illumina HiSeq 2500 platform in 1 × 50 bp format. After processing, 232,826,977 total reads were aligned to the Sus scrofa reference genome (v10.2.79), with 74...
September 2017: Genomics Data
https://www.readbyqxmd.com/read/28699479/micrornas-based-therapy-a-novel-and-promising-strategy-for-cancer-treatment
#16
Ramona Moles
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer. Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, and miR-221 are promising targets to develop a miRNAs-based therapy for human malignancies...
July 10, 2017: MicroRNA
https://www.readbyqxmd.com/read/28691018/genetic-variants-in-the-promoter-region-of-mir-10b-and-the-risk-of-breast-cancer
#17
Jiaping Chen, Yue Jiang, Jing Zhou, Sijun Liu, Yayun Gu, Guangfu Jin, Zhibin Hu, Hongxia Ma, Hongbing Shen, Juncheng Dai
Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28615632/genome-wide-analysis-suggests-a-differential-microrna-signature-associated-with-normal-and-diabetic-human-corneal-limbus
#18
Mangesh Kulkarni, Aleksandra Leszczynska, Gabbie Wei, Michael A Winkler, Jie Tang, Vincent A Funari, Nan Deng, Zhenqiu Liu, Vasu Punj, Sophie X Deng, Alexander V Ljubimov, Mehrnoosh Saghizadeh
Small non-coding RNAs, in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide range of biological processes. However, their roles in normal and diseased limbal epithelial stem cells (LESC) remain unknown. Using deep sequencing analysis, we investigated miRNA expression profiles in central and limbal regions of normal and diabetic human corneas. We identified differentially expressed miRNAs in limbus vs. central cornea in normal and diabetic (DM) corneas including both type 1 (T1DM/IDDM) and type 2 (T2DM/NIDDM) diabetes...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604742/microrna-10b-enhances-pancreatic-cancer-cell-invasion-by-suppressing-tip30-expression-and-promoting-egf-and-tgf-%C3%AE-actions
#19
H Ouyang, J Gore, S Deitz, M Korc
This corrects the article DOI: 10.1038/onc.2013.405.
August 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28599502/microrna-10b-inhibits-proliferation-migration-and-invasion-in-cervical-cancer-cells-via-direct-targeting-of-insulin-like-growth-factor-1-receptor
#20
Ren Hou, Daixian Wang, Jian Lu
MicroRNAs are deregulated in numerous types of human cancers and have crucial roles in the carcinogenesis and progression of human cancers. MicroRNA-10b (miR-10b) has been studied in several types of human cancer. However, the expression and roles of miR-10b in cervical cancer remain unknown. In the present study, the expression, functions and molecular mechanisms of miR-10b were explored in cervical cancer. The present data revealed that miR-10b was significantly downregulated in cervical cancer tissues and cell lines...
June 2017: Oncology Letters
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