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MicroRNA 10b

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https://www.readbyqxmd.com/read/29765554/targeted-nanoparticle-delivery-of-therapeutic-antisense-micrornas-presensitizes-glioblastoma-cells-to-lower-effective-doses-of-temozolomide-in-vitro-and-in-a-mouse-model
#1
Meenakshi Malhotra, Thillai Veerapazham Sekar, Jeyarama S Ananta, Rammohan Devulapally, Rayhaneh Afjei, Husam A Babikir, Ramasamy Paulmurugan, Tarik F Massoud
Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that systemic injection of antisense microRNAs (antagomiR-21 and antagomiR-10b) encapsulated in cRGD-tagged PEG-PLGA nanoparticles would result in high cellular delivery of intact functional antagomiRs, with consequent efficient therapeutic response and increased sensitivity of GBM cells to lower doses of TMZ...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29742582/changes-in-microrna-expression-level-of-circulating-platelets-contribute-to-platelet-defect-after-cardiopulmonary-bypass
#2
Nobuhiro Mukai, Yoshinobu Nakayama, Sachiyo Ishi, Satoru Ogawa, Sachiko Maeda, Natuki Anada, Satoshi Murakami, Toshiki Mizobe, Teiji Sawa, Yasufumi Nakajima
OBJECTIVES: Platelet defect mechanisms after cardiopulmonary bypass remain unclear. Our hypothesis microRNA expressions in circulating platelets significantly change between pre and post cardiopulmonary bypass, and consequent messenger RNA and protein expression level alterations cause postcardiopulmonary bypass platelet defect. DESIGN: Single-center prospective observational study. SETTING: Operating room of Kyoto Prefectural University of Medicine...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29707120/mirna-based-signatures-in-cerebrospinal-fluid-as-potential-diagnostic-tools-for-early-stage-parkinson-s-disease
#3
Marcia Cristina T Dos Santos, Miguel Arturo Barreto-Sanz, Bruna Renata S Correia, Rosie Bell, Catherine Widnall, Luis Tosar Perez, Caroline Berteau, Claudia Schulte, Dieter Scheller, Daniela Berg, Walter Maetzler, Pedro A F Galante, Andre Nogueira da Costa
Parkinson's Disease is the second most common neurodegenerative disorder, affecting 1-2% of the elderly population. Its diagnosis is still based on the identification of motor symptoms when a considerable number of dopaminergic neurons are already lost. The development of translatable biomarkers for accurate diagnosis at the earliest stages of PD is of extreme interest. Several microRNAs have been associated with PD pathophysiology. Consequently, microRNAs are emerging as potential biomarkers, especially due to their presence in Cerebrospinal Fluid and peripheral circulation...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29672315/microrna-10b-promotes-apoptosis-via-jnk-pathway-in-clear-cell-renal-cell-carcinoma
#4
Jianyang Qin, Jia Zhou, Ling Teng, Ying Han
BACKGROUND/AIMS: To investigate the downregulation of microRNA (miR)-10b in clear cell renal cell carcinoma (ccRCC) and its mechanistic involvement in tumourigenesis. METHODS: The relative expression of miR-10b in ccRCC samples were determined by real-time PCR. Exogenous expression and knockdown of endogenous miR-10b were performed by transfection with indicated plasmids into 786-0 cells. Cell proliferation was evaluated using Cell Counting Kit-8 assay. Cell apoptosis was analyzed by Annexin V/propidium iodide staining...
April 19, 2018: Nephron
https://www.readbyqxmd.com/read/29658967/identification-of-microrna-signature-in-different-pediatric-brain-tumors
#5
Marwa Tantawy, Mariam G Elzayat, Dina Yehia, Hala Taha
Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29604463/identification-of-differentially-expressed-micrornas-during-preadipocyte-differentiation-in-chinese-crested-duck
#6
Shasha Wang, Yang Zhang, Xiaoya Yuan, Rui Pan, Wencheng Yao, Li Zhong, Qianqian Song, Shenghan Zheng, Zhixiu Wang, Qi Xu, Guobin Chang, Guohong Chen
MicroRNAs (miRNAs) are considered key players in the regulation of a broad range of biological processes. Specifically, miRNAs have been reported to play an important role in the process of adipogenesis. In this study, we constructed a model of adipogenesis by isolating preadipocytes (WCC) derived from adipose tissue and preadipocytes after 72 h differentiation (WCT) in vitro. Deep sequencing of miRNAs expressed in WCT and WCC cells was conducted; we identified 105 differentially expressed miRNA candidates (fifty up-regulated and fifty-five down-regulated)...
March 28, 2018: Gene
https://www.readbyqxmd.com/read/29602299/identification-of-human-skeletal-muscle-mirna-related-to-strength-by-high-throughput-sequencing
#7
Cameron J Mitchell, Randall F D'Souza, William Schierding, Nina Zeng, Farha Ramzan, Justin M O'Sullivan, Sally D Poppitt, David Cameron-Smith
The loss of muscle size, strength and quality with ageing is a major determinant of morbidity and mortality in the elderly. The regulatory pathways that impact on the muscle phenotype include the translational regulation maintained by microRNAs (miRNA). Yet the miRNAs that are expressed in human skeletal muscle and relationship to muscle size, strength and quality are unknown. Using next-generation sequencing, the 50 most abundantly expressed miRNAs were selected and then analysed in m. vastus lateralis, obtained by biopsy from middle-aged males (n=48; 50...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29599829/microrna-10b-expression-and-its-correlation-with-molecular-subtypes-of-early-invasive-ductal-carcinoma
#8
Chenming Guo, Minggang Fu, Yilamu Dilimina, Sha Liu, Liying Guo
The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, progesterone receptor (PR) and human epidermal growth factor receptor-2 (Her-2). The positive expression rate of miR-10b in patients with early invasive ductal carcinoma with ER-α (+) or PR (+) was decreased compared with ER-α (-) or PR (-) patients (P<0...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29588449/confirmation-of-a-metastasis-specific-microrna-signature-in-primary-colon-cancer
#9
Robert R J Coebergh van den Braak, Anieta M Sieuwerts, Zarina S Lalmahomed, Marcel Smid, Saskia M Wilting, Sandra I Bril, Shanshan Xiang, Michelle van der Vlugt-Daane, Vanja de Weerd, Anne van Galen, Katharina Biermann, J Han J M van Krieken, Wigard P Kloosterman, John A Foekens, John W M Martens, Jan N M IJzermans
The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for these patients based on an understanding of tumour biology. MicroRNAs have been proposed as markers of the prognosis or treatment response in colorectal cancer. Recently, a 2-microRNA signature (let-7i and miR-10b) was proposed to identify colorectal cancer patients at risk of developing distant metastasis. We assessed the prognostic value of this signature and additional candidate microRNAs in an independent, clinically well-defined, prospectively collected cohort of primary colon cancer patients including stage I-II colon cancer without and stage III colon cancer with adjuvant treatment...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29570800/dna-methylation-of-mirna-encoding-genes-in-non-small-cell-lung-cancer-patients
#10
Gerwin Heller, Corinna Altenberger, Irene Steiner, Thais Topakian, Barbara Ziegler, Erwin Tomasich, György Lang, Adelheid End-Pfützenreuter, Sonja Zehetmayer, Balazs Döme, Britt-Madeleine Arns, Walter Klepetko, Christoph C Zielinski, Sabine Zöchbauer-Müller
De-regulated DNA methylation leading to transcriptional inactivation of certain genes occurs frequently in non-small cell lung cancers (NSCLC). Besides protein-encoding genes also microRNA (miRNA)-encoding genes may be targets for methylation in NSCLCs, however, the number of known methylated miRNA genes is still small. Thus, we investigated methylation of miRNA genes in primary tumours (TU) and corresponding non-malignant lung tissue samples (NL) of 50 NSCLC patients using methylated DNA immunoprecipitation followed by custom designed tiling microarray analyses (MeDIP-chip) and 252 differentially methylated probes between TU and NL samples were identified...
March 23, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29552198/microrna-10a-b-are-regulators-of-myeloid-differentiation-and-acute-myeloid-leukemia
#11
Laixi Bi, Lan Sun, Zhenlin Jin, Shenghui Zhang, Zhijian Shen
MicroRNAs (miRs) have been demonstrated to perform important roles in normal hematopoiesis and leukemogenesis. Accumulating evidence suggests that miR-10a and miR-10b may behave as novel oncogenes or tumor suppressors in human cancer. The present study reported the function of the miR-10 family in myeloid differentiation and acute myeloid leukemia (AML). The levels of miR-10a/b expression were increased in AML cases compared with normal controls, particularly in M1, M2 and M3 subtypes. The levels of miR-10a/b expression were also upregulated in patients with nucleophosmin-mutated AML and AML patients with t(8;21) and t(9;11), compared with the normal control...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29514931/voltage-gated-potassium-channel-blocker-4-aminopyridine-induces-glioma-cell-apoptosis-by-reducing-expression-of-microrna-10b-5p
#12
Qin Ru, Wei-Ling Li, Qi Xiong, Lin Chen, Xiang Tian, Chao-Ying Li
Accumulating evidence has demonstrated that voltage-gated potassium channels (Kv channels) were associated with regulating cell proliferation and apoptosis in tumor cells. Our previous study proved that the Kv channel blocker 4-aminopyridine (4-AP) could inhibit cell proliferation and induce apoptosis in glioma. However, the precise mechanisms were not clear yet. MicroRNAs (miRNAs) are small noncoding RNAs that act as key mediators in the progression of tumor, so the aim of this study was to investigate the role of miRNAs in the apoptosis-promoting effect of 4-AP in glioma cells...
May 1, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29434944/microrna-196a-5p-is-a-potential-prognostic-marker-of-delayed-lymph-node-metastasis-in-early-stage-tongue-squamous-cell-carcinoma
#13
Tessho Maruyama, Kazuhide Nishihara, Masato Umikawa, Akira Arasaki, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Kimiko Takei, Saori Nakachi, Ken-Ichi Kariya, Naoki Yoshimi
MicroRNAs (miRs) are expected to serve as prognostic tools for cancer. However, many miRs have been reported as prognostic markers of recurrence or metastasis in oral squamous cell carcinoma patients. We aimed to determine the prognostic markers in early-stage tongue squamous cell carcinoma (TSCC). Based on previous studies, we hypothesized that miR-10a, 10b, 196a-5p, 196a-3p, and 196b were prognostic markers and we retrospectively performed miR expression analyses using formalin-fixed paraffin-embedded sections of surgical specimens...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29409452/whole-blood-micrornas-as-potential-biomarkers-in-post-operative-early-breast-cancer-patients
#14
Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K Trapp, Marie Tzschaschel, Sven Mahner, Peter A Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W P Friedl, Wolfgang Janni, Brigitte Rack
BACKGROUND: microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patients (EBC) to assess the utility of miRNAs as prognostic markers in this setting. METHOD: A total of 48 post-operative patients, recruited in frame of the SUCCESS A trial, were included in this retrospective study and tested with a panel of 8 miRNAs (miR-10b, -19a, - 21, - 22, -20a, - 127, - 155, -200b)...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29408861/microrna-10b-expression-in-breast-cancer-and-its-clinical-association
#15
Jianhui Zhang, Jing Yang, Xin Zhang, Jia Xu, Yiyi Sun, Purong Zhang
MicroRNAs (miRNAs) are short non-coding RNA molecules that play a significant role in many types of cancers including breast cancer. In the current study, we evaluated the expression levels of microR-10b (miR-10b) in 115 breast cancer patients from Sichuan Cancer Center. Real time reverse transcription-PCR was used to assess miR-10b expression. Clinical data including disease stage, survival status, age, ER/PR/HER2 status, molecular subtypes, tumor size, lymph node status and Ki-67 expression levels were correlated with miR-10b expression levels...
2018: PloS One
https://www.readbyqxmd.com/read/29397781/ionizing-radiation-deregulates-the-microrna-expression-profile-in-differentiated-thyroid-cells
#16
Ricardo Cortez Cardoso Penha, Simona Pellecchia, Roberto Pacelli, Luis Felipe Ribeiro Pinto, Alfredo Fusco
BACKGROUND: Ionizing radiation (IR) is a well-known risk factor for papillary thyroid cancer, and it has been reported to deregulate microRNA expression, which is important to thyroid carcinogenesis. Therefore, this study investigated the impact of IR on microRNA expression profile of the normal thyroid cell line (FRTL-5 CL2), as well as its effect on radiosensitivity of thyroid cancer cell lines, especially the human anaplastic thyroid carcinoma cell line (8505c). METHODS: The global microRNA expression profile of irradiated FRTL-5 CL2 cells (5 Gy X-ray) was characterized, and data were confirmed by quantitative real-time polymerase chain reaction evaluating the expression of rno-miR-10b-5p, rno-miR-33-5p, rno-miR-128-1-5p, rno-miR-199a-3p, rno-miR-296-5p, rno-miR-328a-3p, and rno-miR-541-5p in irradiated cells...
March 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29385395/microrna-expression-pattern-differs-depending-on-endometriosis-lesion-type
#17
Maria E Haikalis, Jocelyn M Wessels, Nicholas A Leyland, Sanjay K Agarwal, Warren G Foster
MicroRNA (miRNA), noncoding segments of RNA involved in post-transcriptional regulation of protein expression are differentially expressed in eutopic endometrium of women with and without endometriosis compared to endometriotic lesions. However, endometriotic lesion types are known to be biochemically distinct and therefore hypothesized that miRNAs are differentially expressed in endometriomas compared to peritoneal and deep-infiltrating lesions. Therefore, endometrial biopsies and ectopic implants from women (n = 38) undergoing laparoscopic surgery for chronic pelvic pain were collected...
May 1, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29383182/transcriptomic-analysis-in-pediatric-spinal-ependymoma-reveals-distinct-molecular-signatures
#18
Anbarasu Lourdusamy, Li Z Luo, Lisa Cd Storer, Kenneth J Cohen, Linda Resar, Richard G Grundy
Pediatric spinal ependymomas (SEPN) are important albeit uncommon malignant central nervous system tumors with limited treatment options. Our current knowledge about the underlying biology of these tumors is limited due to their rarity. To begin to elucidate molecular mechanisms that give rise to pediatric SEPN, we compared the transcriptomic landscape of SEPNs to that of intracranial ependymomas using genome-wide mRNA and microRNA (miRNA) expression profiling in primary tumour samples. We found that pediatric SEPNs are characterized by increased expression of genes involved in developmental processes, oxidative phosphorylation, cellular respiration, electron transport chain, and cofactor metabolic process...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29375271/microrna-10b-regulates-epithelial-mesenchymal-transition-by-modulating-klf4-klf11-smads-in-hepatocellular-carcinoma
#19
Gulibaha Hujie, Sheng-Hua Zhou, Hua Zhang, Jie Qu, Xiao-Wei Xiong, Outikuer Hujie, Cheng-Gong Liao, Shun-E Yang
Background: Our previous work showed that miR-10b was overexpressed in hepatocellular carcinoma (HCC) and promoted HCC cell migration and invasion. Epithelial-mesenchymal transition (EMT) is involved in HCC metastasis. So, we suspected that miR-10b might participate in the HCC EMT. Methods: We performed morphological analysis and immunofluorescence to observe the roles of miR-10b in HCC EMT. The expression of KLF11 and EMT markers were detected by real-time RT-PCR and western blot...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29374690/microrna-expression-in-kras-and-braf-mutated-colorectal-cancers
#20
Ida V Lundberg, Maria L Wikberg, Ingrid Ljuslinder, Xingru Li, Robin Myte, Carl Zingmark, Anna Löfgren-Burström, Sofia Edin, Richard Palmqvist
BACKGROUND/AIM: KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expression of microRNAs (miRNAs) could explain the clinicopathological differences seen between KRAS- and BRAF-mutated CRCs. MATERIALS AND METHODS: Using a PCR array, we analyzed the expression of 84 different miRNAs in CRC cell lines wild-type in KRAS and BRAF, or mutated in KRAS or BRAF...
February 2018: Anticancer Research
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