keyword
MENU ▼
Read by QxMD icon Read
search

Cellular theory

keyword
https://www.readbyqxmd.com/read/28430271/theoretical-modulation-of-singlet-triplet-chemiexcitation-of-chemiluminescent-imidazopyrazinone-dioxetanone-via-c8-substitution
#1
L Pinto da Silva, C M Magalhães, D M A Crista, J C G Esteves da Silva
Coelenterazine, a member of the imidazopyrazinone class of chemiluminescent substrates, presents significant potential as a dynamic probe of reactive oxygen species in a biological environment, such as a superoxide anion, in which these species are important in cellular biology and pathology. The objective of the current study was to understand in what way the efficiency of singlet and triplet chemiexcitation could be modulated, towards a more efficient use of imidazopyrazinone-based compounds as dynamic chemiluminescent probes...
April 21, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28428620/formal-definitions-of-unbounded-evolution-and-innovation-reveal-universal-mechanisms-for-open-ended-evolution-in-dynamical-systems
#2
Alyssa Adams, Hector Zenil, Paul C W Davies, Sara Imari Walker
Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on key aspects of open-ended evolution as it appears in biology. We recast the problem as a more general one in dynamical systems theory, providing simple criteria for open-ended evolution based on two hallmark features: unbounded evolution and innovation. We define unbounded evolution as patterns that are non-repeating within the expected Poincare recurrence time of an isolated system, and innovation as trajectories not observed in isolated systems...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425679/soft-interactions-and-volume-exclusion-by-polymeric-crowders-can-stabilize-or-destabilize-transient-structure-in-disordered-proteins-depending-on-polymer-concentration
#3
Farai I Rusinga, David D Weis
The effects of macromolecular crowding on the transient structure of intrinsically disordered proteins is not well-understood. Crowding by biological molecules inside cells could modulate transient structure and alter IDP function. Volume exclusion theory and observations of structured proteins suggest that IDP transient structure would be stabilized by macromolecular crowding. Amide hydrogen exchange (HX) of IDPs in highly concentrated polymer solutions would provide valuable insights into IDP transient structure under crowded conditions...
April 20, 2017: Proteins
https://www.readbyqxmd.com/read/28417973/excitability-in-the-p53-network-mediates-robust-signaling-with-tunable-activation-thresholds-in-single-cells
#4
Gregor Mönke, Elena Cristiano, Ana Finzel, Dhana Friedrich, Hanspeter Herzel, Martin Falcke, Alexander Loewer
Cellular signaling systems precisely transmit information in the presence of molecular noise while retaining flexibility to accommodate the needs of individual cells. To understand design principles underlying such versatile signaling, we analyzed the response of the tumor suppressor p53 to varying levels of DNA damage in hundreds of individual cells and observed a switch between distinct signaling modes characterized by isolated pulses and sustained oscillations of p53 accumulation. Guided by dynamic systems theory we show that this requires an excitable network structure comprising positive feedback and provide experimental evidence for its molecular identity...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417927/wireless-fractal-ultra-dense-cellular-networks
#5
Yixue Hao, Min Chen, Long Hu, Jeungeun Song, Mojca Volk, Iztok Humar
With the ever-growing number of mobile devices, there is an explosive expansion in mobile data services. This represents a challenge for the traditional cellular network architecture to cope with the massive wireless traffic generated by mobile media applications. To meet this challenge, research is currently focused on the introduction of a small cell base station (BS) due to its low transmit power consumption and flexibility of deployment. However, due to a complex deployment environment and low transmit power of small cell BSs, the coverage boundary of small cell BSs will not have a traditional regular shape...
April 12, 2017: Sensors
https://www.readbyqxmd.com/read/28416779/neuronal-network-models-of-epileptogenesis
#6
Aminu T Abdullahi, Lawan H Adamu
Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders. In this review, we briefly describe the concept of neuronal networks and highlight 2 methods used to analyse such networks. The first method, graph theory, is used to describe general characteristics of a network to facilitate comparison between normal and abnormal networks...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28415639/epithelial-to-mesenchymal-transition-in-the-development-of-endometriosis
#7
Yan-Meng Yang, Wan-Xi Yang
Endometriosis, an estrogen-dependent chronic gynecological disease, is common in reproductive-age women and profoundly affects their life quality. Although various pathogenic theories have been proposed, the origin of endometriosis remains unclear. Epithelial to mesenchymal transition (EMT) is a process that epithelial cells lose polarized organization of the cytoskeleton and cell-to-cell contacts, acquiring the high motility of mesenchymal cells. These changes are thought to be prerequisites for the original establishment of endometriotic lesions...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413952/building-new-bridges-between-in-vitro-and-in-vivo-in-early-drug-discovery-where-molecular-modeling-meets-systems-biology
#8
Robert A Pearlstein, Daniel J J McKay, Viktor Hornak, Callum Dickson, Andrei Golosov, Tyler Harrison, Camilo Velez-Vega, José Duca
Cellular drug targets exist within networked function generating systems whose constituent molecular species undergo dynamic interdependent non-equilibrium state transitions in response to specific perturbations (i.e. inputs). Cellular phenotypic behaviors are manifest through the integrated behaviors of such networks. However, in vitro data are frequently measured and/or interpreted with empirical equilibrium or steady state models (e.g. Hill, Michaelis-Menten, Briggs-Haldane) relevant to isolated target populations...
April 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28410135/custom-built-tools-for-the-study-of-deer-antler-biology
#9
Wenhui Chu, Haiping Zhao, Junde Li, Chunyi Li
Deer antlers can be developed into multiple novel models to study growth and development of tissues for biomedical research. To facilitate this process, we have invented and further refined five custom-built tools through three decades of antler research. These are: 1. Pedicle growth detector to pinpoint the timing when pedicle growth is initiated, thus stimuli for pedicle and first antler formation can be investigated and identified. 2. Thin periosteum slice cutter to thinly slice (0.2mm or 0.7 mm thick) a whole piece of antlerogenic periosteum (AP) or pedicle periosteum (PP), which facilitates gene delivery into cells resident in these tissues, thus making transgenic antlers possible...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28393281/reaction-time-impairments-in-decision-making-networks-as-a-diagnostic-marker-for-traumatic-brain-injuries-and-neurological-diseases
#10
Pedro D Maia, J Nathan Kutz
The presence of diffuse Focal Axonal Swellings (FAS) is a hallmark cellular feature in many neurological diseases and traumatic brain injury. Among other things, the FAS have a significant impact on spike-train encodings that propagate through the affected neurons, leading to compromised signal processing on a neuronal network level. This work merges, for the first time, three fields of study: (i) signal processing in excitatory-inhibitory (EI) networks of neurons via population codes, (ii) decision-making theory driven by the production of evidence from stimulus, and (iii) compromised spike-train propagation through FAS...
April 10, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28384477/rethinking-the-pedunculopontine-nucleus-from-cellular-organization-to-function
#11
REVIEW
Juan Mena-Segovia, J Paul Bolam
The pedunculopontine nucleus (PPN) has long been considered an interface between the basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a key position to modulate behavior. Despite the large amount of data obtained over recent decades, a unified theory of its function is still incomplete. By putting together classical concepts and new evidence that dissects the influence of its different neuronal subtypes on their various targets, we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the behavioral state as a result of changes in environmental contingencies...
April 5, 2017: Neuron
https://www.readbyqxmd.com/read/28375630/tuning-electron-transfer-properties-in-5-10-15-20-tetra-1-hexanoylferrocenyl-porphyrins-as-prospective-systems-for-quantum-cellular-automata-and-platforms-for-four-bit-information-storage
#12
Nathan R Erickson, Cole D Holstrom, Hannah M Rhoda, Gregory T Rohde, Yuriy V Zatsikha, Pierluca Galloni, Victor N Nemykin
Metal-free (1) and zinc (2) 5,10,15,20-tetra(1'-hexanoylferrocenyl)porphyrins were prepared using an acid-catalyzed tetramerization reaction between pyrrole and 1'-(1-hexanoyl)ferrocencarboxaldehyde. New organometallic compounds were characterized by combination of (1)H, (13)C, and variable-temperature NMR, UV-vis, magnetic circular dichroism, and high-resolution electrospray ionization mass spectrometry methods. The redox properties of 1 and 2 were probed by electrochemical (cyclic voltammetry and differential pulse voltammetry), spectroelectrochemical, and chemical oxidation approaches coupled with UV-vis-near-IR and Mössbauer spectroscopy...
April 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28374954/multifunctional-gadolinium-doped-mesoporous-tio2-nanobeads-photoluminescence-enhanced-spin-relaxation-and-reactive-oxygen-species-photogeneration-beneficial-for-cancer-diagnosis-and-treatment
#13
Roghayeh Imani, Ralf Dillert, Detlef W Bahnemann, Meysam Pazoki, Tomaž Apih, Veno Kononenko, Neža Repar, Veronika Kralj-Iglič, Gerrit Boschloo, Damjana Drobne, Tomas Edvinsson, Aleš Iglič
Materials with controllable multifunctional abilities for optical imaging (OI) and magnetic resonant imaging (MRI) that also can be used in photodynamic therapy are very interesting for future applications. Mesoporous TiO2 sub-micrometer particles are doped with gadolinium to improve photoluminescence functionality and spin relaxation for MRI, with the added benefit of enhanced generation of reactive oxygen species (ROS). The Gd-doped TiO2 exhibits red emission at 637 nm that is beneficial for OI and significantly improves MRI relaxation times, with a beneficial decrease in spin-lattice and spin-spin relaxation times...
April 4, 2017: Small
https://www.readbyqxmd.com/read/28360887/oxidative-stress-function-in-women-over-40%C3%A2-years-of-age-considering-their-lifestyle
#14
Maria Paula Gonçalves Mota, Zirlene Santos, Jorge Soares, Ana Pereira, Sandra Fonseca, Francisco Peixoto, Isabel Gaivão, Maria Oliveira
Aging is dependent on biological processes that determine the aging of the organism at the cellular level. The Oxidative Stress Theory of Aging might explain some of the age-related changes in cell macromolecules. Moreover, exposome and lifestyle may also induce changes in cell damage induced by oxidative stress. The aim of the present study was to analyze the related redox changes in lymphocyte function of healthy women over 40 years old. Three groups: younger (YG: 40-49 years), middle aged (MAG: 50-59 years), and older (OG: ≥60 years) were evaluated on anthropometric variables, blood pressure, cardiovascular fitness, lifestyle habits, perceived stress, DNA damage, malondialdehyde, catalase activity, and total antioxidant capacity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28358721/cavity-theory-applications-for-kilovoltage-cellular-dosimetry
#15
Patricia A K Oliver, Rowan Thomson
Relationships between macroscopic (bulk tissue) and microscopic (cellular) dose 
descriptors are investigated using cavity theory and Monte Carlo (MC) simulations. 
Small, large, and multiple intermediate cavity theory (SCT, LCT, and ICT, respectively) approaches are considered for 20 to 370 keV incident photons; ICT is a sum 
of SCT and LCT contributions weighted by parameter <i>d</i>. Considering μm-sized cavities of water in bulk tissue phantoms, different cavity theory approaches are evaluated 
via comparison of <i>D<sub>w,m</sub></i>/<i>D<sub>m,m</sub></i> (where <i>D<sub>w,m</sub></i> is dose-to-water-in-medium and <i>D<sub>m,m</sub></i> is 
dose-to-medium-in-medium) with MC results...
March 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28349474/graph-theory-based-analysis-of-the-lymph-node-fibroblastic-reticular-cell-network
#16
Mario Novkovic, Lucas Onder, Gennady Bocharov, Burkhard Ludewig
Secondary lymphoid organs have developed segregated niches that are able to initiate and maintain effective immune responses. Such global organization requires tight control of diverse cellular components, specifically those that regulate lymphocyte trafficking. Fibroblastic reticular cells (FRCs) form a densely interconnected network in lymph nodes and provide key factors necessary for T cell migration and retention, and foster subsequent interactions between T cells and dendritic cells. Development of integrative systems biology approaches has made it possible to elucidate this multilevel complexity of the immune system...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28348254/vertex-models-from-cell-mechanics-to-tissue-morphogenesis
#17
REVIEW
Silvanus Alt, Poulami Ganguly, Guillaume Salbreux
Tissue morphogenesis requires the collective, coordinated motion and deformation of a large number of cells. Vertex model simulations for tissue mechanics have been developed to bridge the scales between force generation at the cellular level and tissue deformation and flows. We review here various formulations of vertex models that have been proposed for describing tissues in two and three dimensions. We discuss a generic formulation using a virtual work differential, and we review applications of vertex models to biological morphogenetic processes...
May 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28345458/proteasome-expression-and-activity-in-cancer-and-cancer-stem-cells
#18
REVIEW
Ioannis A Voutsadakis
Proteasome is a multi-protein organelle that participates in cellular proteostasis by destroying damaged or short-lived proteins in an organized manner guided by the ubiquitination signal. By being in a central place in the cellular protein complement homeostasis, proteasome is involved in virtually all cell processes including decisions on cell survival or death, cell cycle, and differentiation. These processes are important also in cancer, and thus, the proteasome is an important regulator of carcinogenesis...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28344990/inspiired-a-pipeline-for-quantitative-analysis-of-sites-of-new-dna-integration-in-cellular-genomes
#19
Eric Sherman, Christopher Nobles, Charles C Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K Everett, Laure Caccavelli, Mary J Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D Bushman
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy. Tracking the distributions of integration sites is important to characterize populations of transduced cells and to monitor potential outgrow of pathogenic cell clones. Here, we describe a pipeline for quantitative analysis of integration site distributions named INSPIIRED (integration site pipeline for paired-end reads). We describe optimized biochemical steps for site isolation using Illumina paired-end sequencing, including new technology for suppressing recovery of unwanted contaminants, then software for alignment, quality control, and management of integration site sequences...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28343391/single-molecule-peptide-lipid-affinity-assay-reveals-interplay-between-solution-structure-and-partitioning
#20
Tina R Matin, Krishna P Sigdel, Milica Utjesanovic, Brendan P Marsh, Fabio Gallazzi, Virginia F Smith, Ioan Kosztin, Gavin M King
Interactions between short protein segments and phospholipid bilayers dictate fundamental aspects of cellular activity and have important applications in biotechnology. Yet, the lack of a suitable methodology for directly probing these interactions has hindered the mechanistic understanding. We developed a precision atomic force microscopy-based single-molecule force spectroscopy assay and probed partitioning into lipid bilayers by measuring the mechanical force experienced by a peptide. Protein segments were constructed from the peripheral membrane protein SecA, a key ATPase in bacterial secretion...
April 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
keyword
keyword
36081
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"