keyword
MENU ▼
Read by QxMD icon Read
search

Cellular theory

keyword
https://www.readbyqxmd.com/read/27904609/deciphering-biological-characteristics-of-tumorigenic-subpopulations-in-human-colorectal-cancer-reveals-cellular-plasticity
#1
Hamed Mirzaei, Hossein Salehi, Amirhossein Sahebkar, Amir Avan, Mahmoud Reza Jaafari, Afshin Namdar, Abbas Rezaei, Hamid Reza Mirzaei
BACKGROUND: It is supposed that human colorectal cancer consists of a phenotypically distinct population of tumorigenic cancer cells known as cancer stem cells (CSCs) which play a pivotal role in cancer progression, maintenance, metastasis, and the relapse. The aim of this effort was to investigate and compare biological characterizations of CD133(+) with CD133(-) cell subsets isolated from both primary and metastatic human colorectal tumors. MATERIALS AND METHODS: Using our optimized protocols, unfixed colorectal tumors were enzymatically and mechanically dissociated into single cells followed by evaluation of postdigestion viability...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902924/simple-mechanisms-of-early-life-simulation-model-on-the-origin-of-semi-cells
#2
Adrian Klein, Martin Bock, Wolfgang Alt
The development of first cellular structures played an important role in the early evolution of life. Early evolution of life probably took place on a molecular level in a reactive environment. The iron-sulfur theory postulates the formation of cell-like structures on catalytic surfaces. Experiments show that H2S together with FeS and other metallic centers drive auto-catalytic surface reactions, in which organic molecules such as pyruvic and amino acids occur. It is questionable which mechanisms are needed to form cell-like structures under these conditions...
November 27, 2016: Bio Systems
https://www.readbyqxmd.com/read/27895596/reciprocal-modulation-of-ik1-ina-extends-excitability-in-cardiac-ventricular-cells
#3
Anthony Varghese
The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes. An increase in the expression of channels responsible for one of these two currents results in a corresponding increase in expression of the other. These currents are critical in the propagation of action potentials (AP) during the normal functioning of the heart. This study identifies a physiological role for IK1-INa reciprocal modulation in ventricular fiber activation thresholds and conduction...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27895025/medical-treatment-of-aortic-stenosis
#4
Guillaume Marquis-Gravel, Björn Redfors, Martin B Leon, Philippe Généreux
Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27891292/cancer-stem-cells-cellular-plasticity-niche-and-its-clinical-relevance
#5
Gina Lee, Robert R Hall, Atique U Ahmed
Cancer handles an estimated 7.6 million deaths worldwide per annum. A recent theory focuses on the role Cancer Stem Cells (CSCs) in driving tumorigenesis and disease progression. This theory hypothesizes that a population of the tumor cell with similar functional and phenotypic characteristics as normal tissue stem cells are responsible for formation and advancement of many human cancers. The CSCs subpopulation can differentiate into non-CSC tumor cells and promote phenotypic and functional heterogeneity within the tumor...
October 2016: Journal of Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27891204/neutral-impulsive-shunting-inhibitory-cellular-neural-networks-with-time-varying-coefficients-and-leakage-delays
#6
Chaouki Aouiti
In this article, we consider a class of neutral impulsive shunting inhibitory cellular neural networks with time varying coefficients and leakage delays. We study the existence and the exponential stability of the piecewise differentiable pseudo almost-periodic solutions and establish sufficient conditions for the existence and exponential stability of such solutions. An example is provided to illustrate the theory developed in this work.
December 2016: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/27889998/micrornas-and-aging-biomarkers-or-therapeutic-targets
#7
Kyriacos Felekkis
Understanding the molecular mechanism of aging is of utmost importance to the scientific communities. Various theories have been proposed up to date and many of them were evaluated as potential targets in the battle against aging. MicroRNAs, the universal gene expression regulators, were found to be associated with the aging process as many of them have been linked to biological process associated with cellular deterioration. In this short report, we briefly review the contribution of miRNAs to the aging process and offer an opinion as to how the knowledge of therole of these molecules in aging can be utilized...
November 24, 2016: Current Aging Science
https://www.readbyqxmd.com/read/27889642/redox-control-of-senescence-and-age-related-disease
#8
REVIEW
Akshaya Chandrasekaran, Maria Del Pilar Sosa Idelchik, J Andrés Melendez
The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways...
November 16, 2016: Redox Biology
https://www.readbyqxmd.com/read/27886595/synthesis-photophysical-properties-and-systematic-evaluations-of-new-phenanthroimidazole-fluorescent-probe-for-bioimaging-experimental-and-theoretical-study
#9
Przemysław Krawczyk, Beata Jędrzejewska, Marek Pietrzak, Tomasz Janek
In this study, the newly synthesized 4'-(1H-phenantro[9,10-d]-imidazol-2-yl)-bifenyl-4-carboaldehyde - PB2 was investigated as a fluorescent dye. For this reason, the spectroscopic properties in solvents of different polarity were studied. The experimental data were supported by quantum-chemical calculations using density functional theory. Measurements and theoretical calculations showed that PB2 compound is characterized by the non-monotonic solvatochromism, strongly polar charge transfer excited state, large Stokes' shift, high fluorescence quantum yield and high fluorescence lifetime...
November 8, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27885945/clinical-imaging-and-immunohistochemical-characteristics-of-focal-cortical-dysplasia-type-ii-extratemporal-epilepsies-in-children-analyses-of-an-institutional-case-series
#10
Friederike Knerlich-Lukoschus, Mary B Connolly, Glenda Hendson, Paul Steinbok, Christopher Dunham
OBJECTIVE Focal cortical dysplasia (FCD) Type II is divided into 2 subgroups based on the absence (IIA) or presence (IIB) of balloon cells. In particular, extratemporal FCD Type IIA and IIB is not completely understood in terms of clinical, imaging, biological, and neuropathological differences. The aim of the authors was to analyze distinctions between these 2 formal entities and address clinical, MRI, and immunohistochemical features of extratemporal epilepsies in children. METHODS Cases formerly classified as Palmini FCD Type II nontemporal epilepsies were identified through the prospectively maintained epilepsy database at the British Columbia Children's Hospital in Vancouver, Canada...
November 25, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27876574/the-emerging-role-of-ecm-crosslinking-in-t-cell-mobility-as-a-hallmark-of-immunosenescence-in-humans
#11
REVIEW
Jean-Francois Moreau, Thomas Pradeu, Andrea GRignolio, Christine Nardini, Filippo Castiglione, Paolo Tieri, Miriam Capri, Stefano Salvioli, Jean-Luc Taupin, Paolo Garagnani, Claudio Franceschi
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of "inflammaging". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM)...
November 19, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27872658/exploiting-the-dynamic-properties-of-covalent-modification-cycle-for-the-design-of-synthetic-analog-biomolecular-circuitry
#12
Mathias Foo, Rucha Sawlekar, Declan G Bates
BACKGROUND: Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinct input-output mapping behaviours - ultrasensitive, hyperbolic, signal-transducing and threshold-hyperbolic. RESULTS: In this paper, we show how the set of chemical reactions underlying covalent modification cycles can be exploited for the design of synthetic analog biomolecular circuitry...
2016: Journal of Biological Engineering
https://www.readbyqxmd.com/read/27866797/the-impact-of-structural-heterogeneity-on-excitation-inhibition-balance-in-cortical-networks
#13
Itamar D Landau, Robert Egger, Vincent J Dercksen, Marcel Oberlaender, Haim Sompolinsky
Models of cortical dynamics often assume a homogeneous connectivity structure. However, we show that heterogeneous input connectivity can prevent the dynamic balance between excitation and inhibition, a hallmark of cortical dynamics, and yield unrealistically sparse and temporally regular firing. Anatomically based estimates of the connectivity of layer 4 (L4) rat barrel cortex and numerical simulations of this circuit indicate that the local network possesses substantial heterogeneity in input connectivity, sufficient to disrupt excitation-inhibition balance...
November 5, 2016: Neuron
https://www.readbyqxmd.com/read/27862210/the-mechanostat-principle-and-the-osteoprotegerin-opg-rankl-rank-system-part-ii-the-role-of-the-hypothalamic-pituitary-axis
#14
Joanna B Tyrovola
Recent literature provides us with the indication that the ratio of OPG/RANKL concentrations fluctuate in a non-linear (bell-shaped) mode, according to Frost's 'mechanostat' theory, during the application of mechanical strain. A similar cellular signal transduction mechanism to mechanical loading, that may also regulate bone resorptive activities, has nowdays been proposed. Since the skeleton is considered to be an endocrine organ, as such, it may likewise be subject to hypothalamic control. This central regulatory system may continually modulate the adaptation of the bone homeostatic system to external challenges...
November 15, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27855666/prevalence-and-correlates-of-problematic-smartphone-use-in-a-large-random-sample-of-chinese-undergraduates
#15
Jiang Long, Tie-Qiao Liu, Yan-Hui Liao, Chang Qi, Hao-Yu He, Shu-Bao Chen, Joël Billieux
BACKGROUND: Smartphones are becoming a daily necessity for most undergraduates in Mainland China. Because the present scenario of problematic smartphone use (PSU) is largely unexplored, in the current study we aimed to estimate the prevalence of PSU and to screen suitable predictors for PSU among Chinese undergraduates in the framework of the stress-coping theory. METHODS: A sample of 1062 undergraduate smartphone users was recruited by means of the stratified cluster random sampling strategy between April and May 2015...
November 17, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27843124/evolution-of-cell-to-cell-variability-in-stochastic-controlled-heteroplasmic-mtdna-populations
#16
Iain G Johnston, Nick S Jones
Populations of physiologically vital mitochondrial DNA (mtDNA) molecules evolve in cells under control from the nucleus. The evolution of populations of mixed mtDNA types is complicated and poorly understood, and variability of these controlled admixtures plays a central role in the inheritance and onset of genetic disease. Here, we develop a mathematical theory describing the evolution of, and variability in, these stochastic populations for any type of cellular control, showing that cell-to-cell variability in mtDNA and mutant load inevitably increases with time, according to rates that we derive and which are notably independent of the mechanistic details of feedback signaling...
November 3, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27834781/do-cancer-drugs-counteract-neurodegeneration-repurposing-for%C3%A2-alzheimer-s-disease
#17
Fiammetta Monacelli, Michele Cea, Roberta Borghi, Patrizio Odetti, Alessio Nencioni
In spite of in depth investigations in the field of the amyloid cascade hypothesis, so far, no disease modifying therapy has been developed for Alzheimer's disease (AD). The pathophysiology provides some evidence of the inverse correlation between cancer and AD. Both AD and cancer are characterized by abnormal cellular behaviors; trigger factors along with a meta synchronously action is expected to drive cancer or neurodegeneration, supporting, respectively, progressive neuronal loss or uncontrolled cell proliferation in cancer cells...
November 7, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27832454/a-tale-of-two-biographies-the-myth-and-truth-of-barbara-mcclintock
#18
Esha Shah
Evelyn Fox Keller wrote first biography of the Nobel Prize winning geneticist Barbara McClintock in which Keller discussed how McClintock felt being rejected by her peers in the 1950s because she questioned the dominant idea of the particulate gene and instead proposed that the genetic material jumped positions on the chromosome which indicated that the gene did not control but was controlled by the cellular environment. Keller's story of McClintock's life is an account of a woman scientist's conception of science and how her unorthodox views isolated her from the main stream science...
December 2016: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/27824360/association-of-atp6v1b2-rs1106634-with-lifetime-risk-of-depression-and-hippocampal-neurocognitive-deficits-possible-novel-mechanisms-in-the-etiopathology-of-depression
#19
X Gonda, N Eszlari, I M Anderson, J F W Deakin, G Bagdy, G Juhasz
Current understanding and treatment of depression is limited to the monoaminergic theory with little knowledge of the involvement of other cellular processes. Genome-wide association studies, however, implicate several novel single-nucleotide polymorphisms with weak but replicable effects and unclarified mechanisms. We investigated the effect of rs1106634 of the ATPV1B2 gene encoding the vacuolar H+ATPase on lifetime and current depression and the possible mediating role of neuroticism by logistic and linear regression in a white European general sample of 2226 subjects...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27823927/physical-mechanisms-of-micro-and-nanodomain-formation-in-multicomponent-lipid-membranes
#20
REVIEW
Friederike Schmid
This article summarizes a variety of physical mechanisms proposed in the literature, which can generate micro- and nanodomains in multicomponent lipid bilayers and biomembranes. It mainly focusses on lipid-driven mechanisms that do not involve direct protein-protein interactions. Specifically, it considers (i) equilibrium mechanisms based on lipid-lipid phase separation such as critical cluster formation close to critical points, and multiple domain formation in curved geometries, (ii) equilibrium mechanisms that stabilize two-dimensional microemulsions, such as the effect of linactants and the effect of curvature-composition coupling in bilayers and monolayers, and (iii) non-equilibrium mechanisms induced by the interaction of a biomembrane with the cellular environment, such as membrane recycling and the pinning effects of the cytoplasm...
November 5, 2016: Biochimica et Biophysica Acta
keyword
keyword
36081
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"