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https://www.readbyqxmd.com/read/28227850/a-kalman-filter-to-estimate-altitude-change-during-a-fall
#1
Michael C Stevens, Wei Lu, Changhong Wang, Stephen J Redmond, Nigel H Lovell, Michael C Stevens, Wei Lu, Changhong Wang, Stephen J Redmond, Nigel H Lovell, Changhong Wang, Wei Lu, Stephen J Redmond, Nigel H Lovell, Michael C Stevens
Barometers have been incorporated into fall detectors in order to enhance the accuracy of fall detection algorithms, however they are power-hungry devices. We present an offline evaluation of a Kalman filter (KF) for estimating the pressure change during a fall that enables low-power operation of the barometer. The KF takes advantage of the fact that a semi-permeable air membrane on a waterproof fall detector enclosure causes a delay in the equilibrium between internal and external enclosure pressure, and this delay enables the barometer to be switched off until a free-fall is detected...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227816/a-wide-range-and-high-sensitivity-four-channel-compact-electrochemical-biosensor-for-neurotransmitter-detection-on-a-microfluidic-platform
#2
Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Mounir Boukadoum, Hamza Landari
We present a four-channel, high-sensitivity and linearity electrochemical biosensor for neurotransmitter (NT) detection and measurement. Using a multi-channel microfluidic platform makes this biosensor capable of detecting NT-related currents going from nanoamperes to milliamperes, with a sensitivity of the order of picoamperes. Moreover, by using a fully differential potentiostat architecture, the biosensor offers a high common-mode rejection ratio (90 dB), making it appropriate for low-noise and high-sensitive applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227207/photoacoustic-imaging-based-temperature-monitoring-for-high-intensity-focused-ultrasound-therapy
#3
Xun Wu, Jean Lunsford Sanders, Douglas N Stephens, Omer Oralkan, Xun Wu, Jean Lunsford Sanders, Douglas N Stephens, Omer Oralkan, Douglas N Stephens, Jean Lunsford Sanders, Omer Oralkan, Xun Wu
Temperature monitoring during high-intensity focused ultrasound (HIFU) application is necessary to ensure effective therapy while minimizing thermal damage to adjacent tissue. In this study, we demonstrate a noninvasive approach for temperature measurement during HIFU therapy based on photoacoustic imaging (PAI). Because of the dependence of photoacoustic (PA) signal amplitude on temperature of the source tissue and the linearity of the PAI system, changes in temperature will cause changes in PA image intensity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227130/verification-of-a-research-prototype-for-hemodynamic-analysis-of-cerebral-aneurysms
#4
Takashi Suzuki, Cosmin Ioan Nita, Saikiran Rapaka, Hiroyuki Takao, Viorel Mihalef, Soichiro Fujimura, Chihebeddine Dahmani, Puneet Sharma, Hiroya Mamori, Toshihiro Ishibashi, Thomas Redel, Makoto Yamamoto, Yuichi Murayama, Takashi Suzuki, Cosmin Ioan Nita, Saikiran Rapaka, Hiroyuki Takao, Viorel Mihalef, Soichiro Fujimura, Chihebeddine Dahmani, Puneet Sharma, Hiroya Mamori, Toshihiro Ishibashi, Thomas Redel, Makoto Yamamoto, Yuichi Murayama, Cosmin Ioan Nita, Puneet Sharma, Hiroya Mamori, Soichiro Fujimura, Thomas Redel, Saikiran Rapaka, Chihebeddine Dahmani, Toshihiro Ishibashi, Makoto Yamamoto, Viorel Mihalef, Takashi Suzuki, Hiroyuki Takao, Yuichi Murayama
Owing to its clinical importance, there has been a growing body of research on understanding the hemodynamics of cerebral aneurysms. Traditionally, this work has been performed using general-purpose, state-of-the-art commercial solvers. This has meant requiring engineering expertise for making appropriate choices on the geometric discretization, time-step selection, choice of boundary conditions etc. Recently, a CFD research prototype has been developed (Siemens Healthcare GmbH, Prototype - not for diagnostic use) for end-to-end analysis of aneurysm hemodynamics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227060/a-statistical-estimation-framework-for-energy-expenditure-of-physical-activities-from-a-wrist-worn-accelerometer
#5
Qiao Wang, Suhas Lohit, Meynard John Toledo, Matthew P Buman, Pavan Turaga, Qiao Wang, Suhas Lohit, Meynard John Toledo, Matthew P Buman, Pavan Turaga, Pavan Turaga, Suhas Lohit, Qiao Wang, Matthew P Buman, Meynard John Toledo
Energy expenditure (EE) estimation from accelerometer-based wearable sensors is important to generate accurate assessment of physical activity (PA) in individuals. Approaches hitherto have mainly focused on using accelerometer data and features extracted from these data to learn a regression model to predict EE directly. In this paper, we propose a novel framework for EE estimation based on statistical estimation theory. Given a test sequence of accelerometer data, the probability distribution on the PA classes is estimated by a classifier and these predictions are used to estimate EE...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226927/possible-photoacoustic-gas-detection-for-a-smart-endoscope
#6
Naoki Wadamori, Naoki Wadamori, Naoki Wadamori
Endogenous gas analysis is a potentially fast and convenient noninvasive diagnostic method for a variety of diseases. However, sampling and sample preparation are error-prone steps and must be optimized to achieve reliable results. A miniature photoacoustic system was developed to allow gas sampling using a smart endoscope. The photoacoustic system was demonstrated to have a 1% detection limit for CO2, which is too high. Many improvements, including modifying the structure of PA cell, must be considered for further development...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226889/dual-mode-cmos-analog-front-end-afe-for-electrical-impedance-spectroscopy-eis-systems
#7
Virgilio Valente, Dai Jiang, Andreas Demosthenous, Virgilio Valente, Dai Jiang, Andreas Demosthenous, Dai Jiang, Andreas Demosthenous, Virgilio Valente
This paper presents the operation of a dual-mode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226192/carbazole-linked-nir-aza-bodipy-dyes-as-triplet-sensitizers-and-photoacoustic-contrast-agents-for-deep-tissue-imaging
#8
Nagaiyan Sekar, Ramaiah D, Yogesh Gawale, Adarsh N, Joseph J, M Pramanik, S K Kalva
Four novel N-ethylcarbazole linked aza-BODIPY dyes (8a-b and 9a-b) were synthesized and characterized. The presence of N-ethylcarbazole moiety shifts their absorption and fluorescence spectra to the near-infrared region, ca. 650-730 nm, of electromagnetic spectra. These dyes possess strong molar absorptivity in the range of 3-4 x 104 M-1cm-1 with low fluorescence quantum yields. The triplet excited state as well as singlet oxygen generation of these dyes were enhanced upon iodination at the core position. The core iodinated dyes 9a-b showed excellent triplet quantum yield of ca...
February 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28225005/autophagy-protects-against-palmitic-acid-induced-apoptosis-in-podocytes-in-vitro
#9
Xu-Shun Jiang, Xue-Mei Chen, Jiang-Min Wan, Hai-Bo Gui, Xiong-Zhong Ruan, Xiao-Gang Du
Autophagy is a highly conserved degradation process that is involved in the clearance of proteins and damaged organelles to maintain intracellular homeostasis and cell integrity. Type 2 diabetes is often accompanied by dyslipidemia with elevated levels of free fatty acids (FFAs). Podocytes, as an important component of the filtration barrier, are susceptible to lipid disorders. The loss of podocytes causes proteinuria, which is involved in the pathogenesis of diabetic nephropathy. In the present study, we demonstrated that palmitic acid (PA) promoted autophagy in podocytes...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224375/lanolin-based-organogel-of-salicylic-acid-evidences-of-better-dermatokinetic-profile-in-imiquimod-induced-keratolytic-therapy-in-balb-c-mice-model
#10
Gajanand Sharma, Neelam Devi, Kanika Thakur, Ashay Jain, O P Katare
The primary aim of the present study was to develop lanolin-based organogel with enhanced delivery potential and reduced skin irritation for the treatment of hyperkeratotic lesions and scaling. The drug was encapsulated in the lipidic bilayers of organogel. The values of particle size, polydispersity index (PDI), and zeta potential of the developed carrier system was found to be 257.5 nm, 0.272, and -24.9 mV, respectively. The system was pseudoplastic in nature with the yield value of 2.3078 Pa. The skin permeation studies exhibited superiority of the prepared lanolin-based organogel formulation over the conventional gel formulation (CGF)...
February 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28223999/factor-analysis-of-myb-gene-expression-and-flavonoid-affecting-petal-color-in-three-crabapple-cultivars
#11
Jie Zhang, Yingying Liu, YuFen Bu, Xi Zhang, Yuncong Yao
Flavonoid biosynthesis has received much attention concerning the structural genes and expression of the associated transcription factors (TFs). In the present study, we examined the gene expression patterns for petals of three colors using a statistical method. Factor analysis was successfully used to examine the expression patterns most present during regulation. The first expression patterns in the white and red petals were clearly demonstrated and have revealed different mechanisms of producing the proper components, whereas that in the pink petals was more complex, requiring factor analysis to supplement the other results...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28223993/diacylglycerol-kinases-are-widespread-in-higher-plants-and-display-inducible-gene-expression-in-response-to-beneficial-elements-metal-and-metalloid-ions
#12
Hugo F Escobar-Sepúlveda, Libia I Trejo-Téllez, Paulino Pérez-Rodríguez, Juan V Hidalgo-Contreras, Fernando C Gómez-Merino
Diacylglycerol kinases (DGKs) are pivotal signaling enzymes that phosphorylate diacylglycerol (DAG) to yield phosphatidic acid (PA). The biosynthesis of PA from phospholipase D (PLD) and the coupled phospholipase C (PLC)/DGK route is a crucial signaling process in eukaryotic cells. Next to PLD, the PLC/DGK pathway is the second most important generator of PA in response to biotic and abiotic stresses. In eukaryotic cells, DGK, DAG, and PA are implicated in vital processes such as growth, development, and responses to environmental cues...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28223953/predicting-future-reading-problems-based-on-pre-reading-auditory-measures-a-longitudinal-study-of-children-with-a-familial-risk-of-dyslexia
#13
Jeremy M Law, Maaike Vandermosten, Pol Ghesquière, Jan Wouters
Purpose: This longitudinal study examines measures of temporal auditory processing in pre-reading children with a family risk of dyslexia. Specifically, it attempts to ascertain whether pre-reading auditory processing, speech perception, and phonological awareness (PA) reliably predict later literacy achievement. Additionally, this study retrospectively examines the presence of pre-reading auditory processing, speech perception, and PA impairments in children later found to be literacy impaired. Method: Forty-four pre-reading children with and without a family risk of dyslexia were assessed at three time points (kindergarten, first, and second grade)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28223717/scale-up-and-pharmacokinetic-study-of-a-novel-mutated-chimeric-tissue-plasminogen-activator-mt-pa-in-rats
#14
Mozhgan Raigani, Mohammad-Reza Rouini, Ali-Akbar Golabchifar, Esmat Mirabzadeh, Behrouz Vaziri, Farzaneh Barkhordari, Fatemeh Davami, Fereidoun Mahboudi
Because of high mortality caused by cardiovascular diseases, various fibrinolytic agents with diverse pharmacokinetic and pharmacodynamic properties have been developed. A novel mutated chimeric tissue plasminogen activator (mt-PA) was developed by the removal of first three domains of t-PA, insertion of GHRP sequence and mutation towards resistance to plasminogen activator inhibitor-1 (PAI-1). Mt-PA protein was expressed in Expi293F cells. The expression level of mt-PA was found to be 5000 IU/mL. Following purification, the pharmacokinetic properties of mt-PA were evaluated in three doses in rats...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223357/lipid-sensing-by-mtor-via-de-novo-synthesis-of-phosphatidic-acid
#15
Deepak Menon, Darin Salloum, Elyssa Bernfeld, Elizabeth Gorodetsky, Alla Akselrod, Maria A Frias, Jessica Sudderth, Pei-Hsuan Chen, Ralph DeBerardinis, David A Foster
mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA)(2) interacts with the FRB (FK506 binding protein-12-rapamycin binding) domain of mTOR, which stabilizes both mTOR complexes - mTORC1 and mTORC2. We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis...
February 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28222621/digestive-and-urologic-hemorrhage-after-intravenous-thrombolysis-for-acute-ischemic-stroke-data-from-a-chinese-stroke-center
#16
Hong Chang, Xiaojuan Wang, Xin Yang, Haiqing Song, Yuchen Qiao, Jia Liu
Objective Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) is considered the most effective treatment method for AIS; however, it is associated with a risk of hemorrhage. We analyzed the risk factors for digestive and urologic hemorrhage during rt-PA therapy. Methods We retrospectively analyzed patients with AIS who underwent intravenous thrombolysis with rt-PA during a 5-year period in a Chinese stroke center. Data on the demographics, medical history, laboratory test results, and clinical outcomes were collected...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28222499/prediction-of-the-level-and-duration-of-shear-stress-exposure-that-induces-subhemolytic-damage-to-erythrocytes
#17
Michael J Simmonds, Herbert J Meiselman
BACKGROUND: Current generation mechanical circulatory assist devices are designed to minimize high shears to blood for prolonged durations to avoid hemolysis. However, red blood cells (RBC) demonstrate impaired capacity to deform when exposed to shear stress (SS) well below the "hemolytic threshold". OBJECTIVE: We endeavored to identify how changes in the magnitude and duration of SS exposure alter RBC deformability and subsequently develop a model to predict erythrocyte subhemolytic damage...
February 9, 2017: Biorheology
https://www.readbyqxmd.com/read/28222449/characterization-of-cutaneous-plasmacytosis-at-different-disease-stages
#18
Pa-Fan Hsiao, Yu-Hung Wu
BACKGROUND/AIMS: Cutaneous plasmacytosis is rare and still not well understood. A retrospective study was made of 9 Chinese patients with 1- to 15-year histories of biopsy-proven cutaneous plasmacytosis diagnosed between 2003 and 2015. METHODS: Patient records and archival photographs helped establish the pattern and duration of skin lesions, and skin biopsy specimens provided additional data. RESULTS: The mean age at diagnosis was 46.4 years...
February 22, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28222238/thrombolysis-with-intravenous-recombinant-tissue-plasminogen-activator-during-early-postpartum-period-a-review-of-the-literature
#19
Munetoshi Akazawa, Makoto Nishida
Thromboembolic events are one of the leading causes of maternal death during the postpartum period. Postpartum thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is controversial because the treatment may lead to massive bleeding. Data centralization may be beneficial for analyzing the safety and effectiveness of systemic thrombolysis during the early postpartum period. We performed a computerized MEDLINE and EMBASE search. We collected data for 13 cases of systemic thrombolytic therapy during the early postpartum period, when limiting the early postpartum period to 48 hours after delivery...
February 21, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28222085/physical-activity-promotion-beliefs-and-barriers-among-australasian-oncology-nurses
#20
Justin W L Keogh, Petra Pühringer, Alicia Olsen, Sally Sargeant, Lynnette M Jones, Mike Climstein
PURPOSE/OBJECTIVES: To describe the physical activity (PA) promotion practices, beliefs, and barriers of Australasian oncology nurses and gain preliminary insight into how PA promotion practices may be affected by the demographics of the nurses.
. DESIGN: Cross-sectional survey.
. SETTING: Australia and New Zealand.
. SAMPLE: 119 registered oncology nurses.
. METHODS: Self-reported online survey completed once per participant...
March 1, 2017: Oncology Nursing Forum
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