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https://www.readbyqxmd.com/read/29793181/exogenously-applied-spermidine-alleviates-photosynthetic-inhibition-under-drought-stress-in-maize-zea-mays-l-seedlings-associated-with-changes-in-endogenous-polyamines-and-phytohormones
#1
Lijie Li, Wanrong Gu, Jing Li, Congfeng Li, Tenglong Xie, Danyang Qu, Yao Meng, Caifeng Li, Shi Wei
Drought stress (DS) is a major environmental factor limiting plant growth and crop productivity worldwide. It has been established that exogenous spermidine (Spd) stimulates plant tolerance to DS. The effects of exogenous Spd on plant growth, photosynthetic performance, and chloroplast ultrastructure as well as changes in endogenous polyamines (PAs) and phytohormones were investigate in DS-resistant (Xianyu 335) and DS-sensitive (Fenghe 1) maize seedlings under well-watered and DS treatments. Exogenous Spd alleviated the stress-induced reduction in growth, photosynthetic pigment content, photosynthesis rate (Pn ) and photochemical quenching (qP ) parameters, including the maximum photochemistry efficiency of photosystem II (PSII) (Fv /Fm ), PSII operating efficiency (ФPSII), and qP coefficient...
May 15, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29793152/identification-of-seven-polyamine-oxidase-genes-in-tomato-solanum-lycopersicum-l-and-their-expression-profiles-under-physiological-and-various-stress-conditions
#2
Yanwei Hao, Binbin Huang, Dongyu Jia, Taylor Mann, Xinyi Jiang, Yuxing Qiu, Masaru Niitsu, Thomas Berberich, Tomonobu Kusano, Taibo Liu
Polyamines (PAs) are implicated in developmental processes and stress responses of plants. Polyamine oxidases (PAOs), flavin adenine dinucleotide-dependent enzymes that function in PA catabolism, play a critical role. Even though PAO gene families of Arabidopsis and rice have been intensely characterized and their expression in response to developmental and environmental changes has been investigated, little is known about PAOs in tomato (Solanum lycopersicum). We found seven PAO genes in S. lycopersicum and named them SlPAO1∼7...
May 15, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29792849/the-role-and-mechanism-of-k-ca-3-1-channels-in-human-monocyte-migration-induced-by-palmitic-acid
#3
Xiao-Zhen Ma, Zheng-Da Pang, Jun-Hong Wang, Zheng Song, Li-Mei Zhao, Xiao-Jun Du, Xiu-Ling Deng
Monocyte migration into diseased tissues contributes to the pathogenesis of diseases. Intermediate-conductance Ca2+ -activated K+ (KCa 3.1) channels play an important role in cell migration. However, the role of KCa 3.1 channels in mediating monocyte migration induced by palmitic acid (PA) is still unclear. Using cultured THP-1 cells and peripheral blood mononuclear cells from healthy subjects, we investigated the role and signaling mechanisms of KCa 3.1 channels in mediating the migration induced by PA. Using methods of Western blotting analysis, RNA interference, cell migration assay and ELISA, we found that PA-treated monocytes exhibited increment of the protein levels of KCa 3...
May 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29792796/nano-lc-nsi-ms-refines-lipidomics-by-enhancing-lipid-coverage-measurement-sensitivity-and-linear-dynamic-range
#4
Niklas Danne-Rasche, Cristina Coman, Robert Ahrends
Nano-liquid chromatography (nLC) - nano-electrospray (NSI) is one of the cornerstones of mass spectrometry based bioanalytics. Nevertheless, the application of nLC is not prevailing lipid analyses so far. In this study, we established a reproducible nLC separation for global lipidomics and describe the merits of using such a miniaturized system for lipid analyses. In order to enable comprehensive lipid analyses that is not restricted to specific lipid classes, we particularly optimized sample preparation conditions and reversed phase separation parameters...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792130/weekday-weekend-variations-in-mother-father-child-physical-activity-and-screen-time-relationship-a-cross-sectional-study-in-a-random-sample-of-czech-families-with-5-to-12-year-old-children
#5
Dagmar Sigmundová, Petr Badura, Erik Sigmund, Jens Bucksch
This study assessed the associations between these factors in a random sample of Czech families with preschool and school-aged children. A nationally representative sample comprised 185 families with preschool children and 649 families with school-aged children (dyads; both parents and child n = 365, mother and child n = 730, and father and child n = 469). The participants wore Yamax Digiwalker SW-200 pedometers at least four weekdays and both weekend days and completed family logbooks (anthropometric parameters, daily step counts (SC), and screen time (ST))...
May 23, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29790537/physical-defects-in-basement-membrane-mimicking-collagen-iv-matrices-trigger-cellular-emt-and-invasion
#7
Christopher Walter, Joshua T Davis, Jairaj Mathur, Amit Pathak
In fibrosis and cancer, degradation of basement membrane (BM) and cell invasion are considered as key outcomes of a cellular transformation called epithelial-mesenchymal transition (EMT). Here, we pose a converse question - can preexisting physical defects in the BM matrix cause EMT in normal epithelial cells? On a BM-mimicking matrix of collagen-IV-coated polyacrylamide (PA) gel, we have discovered a reverse phenomenon in which preexisting defects trigger EMT in normal epithelial cells. Through spatiotemporal measurements and simulations in silico, we demonstrate that the EMT precedes cellular mechanoactivation on defective matrices, but they occur concurrently on stiff matrices...
May 23, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29790478/validation-of-a-novel-non-hyperaemic-index-of-coronary-artery-stenosis-severity-the-resting-full-cycle-ratio-validate-rfr-study
#8
Johan Svanerud, Jung-Min Ahn, Allen Jeremias, Marcel van 't Veer, Ankita Gore, Akiko Maehara, Aaron Crowley, Nico H J Pijls, Bernard De Bruyne, Nils P Johnson, Barry Hennigan, Stuart Watkins, Colin Berry, Keith G Oldroyd, Seung-Jung Park, Ziad A Ali
AIMS: Randomised controlled trials have reported instantaneous wave-free ratio (iFR) to be non-inferior to fractional flow reserve (FFR) for major adverse cardiovascular events at one year; however, iFR is limited by sensitive landmarking of the pressure waveform, and the assumption that maximal flow and minimal resistance occur during a fixed period of diastole. We sought to validate the resting full-cycle ratio (RFR), a novel non-hyperaemic index of coronary stenosis severity based on unbiased identification of the lowest distal coronary pressure to aortic pressure ratio (Pd/Pa), independent of the ECG, landmark identification, and timing within the cardiac cycle...
May 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29790409/postural-stability-and-physical-activity-of-workers-working-at-height
#9
Magdalena Cyma, Katarzyna Marciniak, Maciej Tomczak, Rafał Stemplewski
The purpose of the study was to analyze the level of postural stability and physical activity of at-height workers. The study included 34 healthy men aged 25-43. Two groups were identified based on the type of work they performed: at-height workers (HW) ( n = 17), and office workers (OW) ( n = 17). Physical activity, including physical activity at work, sports activity, and leisure, was assessed with a Baecke questionnaire. For evaluation of postural stability, the one-leg standing test with eyes open and closed was used...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29789938/meta-analysis-of-physical-activity-and-effects-of-social-function-and-quality-of-life-on-the-physical-activity-in-patients-with-schizophrenia
#10
Kazutaka Ohi, Yuzuru Kataoka, Takamitsu Shimada, Aki Kuwata, Hiroaki Okubo, Kohei Kimura, Toshiki Yasuyama, Takashi Uehara, Yasuhiro Kawasaki
Schizophrenia patients have increased mortality and morbidity, mainly due to premature cardiovascular disease resulting from decreased physical activity (PA). However, which PA intensity is impaired in the patients and how factors such as social function and quality of life (QoL) are related to decreased PA is unknown. To assess PA, social function and QoL, the International Physical Activity Questionnaire (IPAQ), Social Functioning Scale (SFS) and Schizophrenia Quality of Life Scale (SQLS), respectively, were used in 109 schizophrenia patients and 69 healthy subjects...
May 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29789689/postmenopausal-osteoporosis-is-associated-with-elevated-aldosterone-renin-ratio
#11
Xiaoyu Shu, Mei Mei, Linqiang Ma, Zhihong Wang, Shumin Yang, Jinbo Hu, Ying Song, Wenwen He, Ting Luo, Qingfeng Cheng, Yue Wang, Qianna Zhen, Qifu Li
Plasma aldosterone/renin ratio (ARR) is a useful method for primary aldosteronism (PA) screening. However some confounders, such as medications and dietary, affect plasma renin and aldosterone levels, resulting in false-negative or -positive plasma ARR. This study investigated the association between postmenopausal osteoporosis (PMO) and plasma ARR. Bone mineral density (BMD) was measured by dual-energy X-ray-absorptiometry (DXA) in 324 normotensive postmenopausal women. Based on clinical characteristics and BMD, 186 and 96 subjects were diagnosed as PMO and osteopenia respectively, and the remaining 42 subjects were grouped as normal BMD...
May 22, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29789344/pgc-1%C3%AE-as-a-biomarker-of-physical-activity-protective-effect-on-colorectal-cancer
#12
Fernanda De Souza-Teixeira, Jéssica Alonso-Molero, Carlos Ayán, Laura Vilorio-Marques, Antonio J Molina, Carmen González-Donquiles, Veronica Davila-Batista, Tania Fernández-Villa, Jose Antonio de Paz, Vicente Martín
Colorectal cancer is a significant public health concern. As a multistage and multifactorial disease, environmental and genetic factors interact at each stage of the process, and an individual's lifestyle also plays a relevant role. We set out to review the scientific evidence to study the need to investigate the role of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) gene as a biomarker of the physical activity's (PA) effect on colorectal cancer. PA is a protective factor against colorectal cancer and usually increases the expression of PGC-1α...
May 22, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29788858/capacity-of-objective-measures-of-physical-activity-to-predict-brazilian-children-s-low-motor-proficiency
#13
Manoella O Santos, Diego G Barbosa, Geraldo J F Junior, Raísa C Silva, Andreia Pelegrini, Érico P G Felden
This study analyzed the associations between physical activity (PA) and motor proficiency (MP) so as to determine what level of moderate PA might help avoid low MP in 8-10-year-old Brazilian children. We assessed MP of 98 children using the Bruininks-Oseretsky Motor Proficiency, Second Edition Short Form (BOT-2 SF), and we assessed PA using the GT3X + accelerometer. We analyzed data using means, standard deviations, frequency distribution, spearman coefficient correlation test, Mann-Whitney U test, and receiver operating characteristics curve...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29788543/a-new-glutathione-conjugate-of-the-pyrrolizidine-alkaloids-produced-by-human-cytosolic-enzyme-dependent-reactions-in-vitro
#14
Fashe Muluneh, Merja R Häkkinen, Rami El-Dairi, Markku Pasanen, Risto O Juvonen
RATIONALE: The toxic metabolites of pyrrolizidine alkaloids (PAs) are initially formed by cytochrome P450 mediated oxidation reactions and primarily eliminated as glutathione (GSH) conjugates. Although the reaction between the reactive metabolites and GSH can occur spontaneously, the role of the cytosolic enzymes in the process has not been studied. METHODS: The toxic metabolites of selected PAs (retrorsine, monocrotaline, senecionine, lasiocarpine, heliotrine or senkirkine) were generated by incubating them in 100 mM phosphate buffer pH 7...
May 22, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29788165/physical-activity-in-relation-to-risk-of-prostate-cancer-a-systematic-review-and-meta-analysis
#15
I N Benke, M F Leitzmann, G Behrens, D Schmid
Background: Prostate cancer (PCa) is one of the most common cancers among men, yet little is known about its modifiable risk and protective factors. This study aims to quantitatively summarize observational studies relating physical activity (PA) to PCa incidence and mortality. Materials and methods: Published articles pertaining to PA and PCa incidence and mortality were retrieved in July 2017 using the Medline and EMBASE databases. The literature review yielded 48 cohort studies and 24 case-control studies with a total of 151 748 PCa cases...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29787553/logistics-of-air-medical-transport-when-and-where-does-helicopter-transport-reduce-prehospital-time-for-trauma
#16
Xilin Chen, Mark L Gestring, Matthew R Rosengart, Andrew B Peitzman, Timothy R Billiar, Jason L Sperry, Joshua B Brown
BACKGROUND: Trauma is a time sensitive disease. Helicopter emergency medical services (HEMS) have shown benefit over ground EMS (GEMS), which may be related to reduced prehospital time. The distance at which this time benefit emerges depends on many factors that can vary across regions. Our objective was to determine the threshold distance at which HEMS has shorter prehospital time than GEMS under different conditions. METHODS: Patients in the PA trauma registry 2000-2013 were included...
May 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787510/metacognition-formative-assessment-and-student-perspective-learning-about-metacognition-through-in-class-comparison-of-response-systems
#17
Melanie Brady, Christopher P Forest
PURPOSE: Educators influence learning context through, among other things, triadic reciprocal causation-a behavioral model used in social cognitive theory. Eliciting responses from learners during instruction may contribute to learning by engaging their metacognition. In this study, metacognition was examined based on learners' experience with 2 different polling methods: student response systems (SRS), commonly known as "clickers," and a low-technology response system (LTRS), where students raise labeled signs, each with a different response...
June 2018: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29787509/use-of-moulage-to-evaluate-student-assessment-of-skin-in-an-objective-structured-clinical-examination
#18
Jennifer Zorn, Jennifer Snyder, Jennifer Guthrie
PURPOSE: This study investigated the physician assistant (PA) student evaluation of skin and the use of moulage in an objective structured clinical examination (OSCE). METHODS: Clinical-year PA students participated in an OSCE, taking a history, completing a physical examination, and writing a focused clinical note. The standardized patient's history simulated a primary diagnosis of right-sided carpal tunnel syndrome and an incidental skin lesion consistent with melanoma, only if the student made an inquiry in this replication study...
June 2018: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29787508/impact-of-a-required-service-learning-curriculum-on-preclinical-students
#19
Christopher P Forest, Désirée A Lie
PURPOSE: The impact of brief service-learning curricula on physician assistant (PA) students is not well reported. This study explores student learning immediately and then one to 2 years after a preclinical service-learning experience through written reflections and a survey. METHODS: The 16-hour curriculum within a behavioral science course involved community immersion and engagement with underserved clients. Reflections written by students from 3 consecutive classes were coded for major themes, and theme frequency was assessed...
June 2018: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29787482/physical-performance-in-relation-to-menopause-status-and-physical-activity
#20
Dmitriy Bondarev, Eija K Laakkonen, Taija Finni, Katja Kokko, Urho M Kujala, Pauliina Aukee, Vuokko Kovanen, Sarianna Sipilä
OBJECTIVE: The aim of this study was to examine differences in physical performance (muscle power, muscle strength, aerobic capacity, and walking speed) across menopausal stages and potential of leisure physical activity (PA) to modify the impact of menopause on physical performance. METHODS: In this cross-sectional study, women aged 47 to 55 were randomly selected from the Finnish National Registry and categorized as premenopausal (n = 233), perimenopausal (n = 381), or postmenopausal (n = 299) based on serum concentrations of follicle-stimulating hormone and bleeding diary...
May 21, 2018: Menopause: the Journal of the North American Menopause Society
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