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https://www.readbyqxmd.com/read/29166651/stiffness-analysis-of-3d-spheroids-using-microtweezers
#1
Devina Jaiswal, Norah Cowley, Zichao Bian, Guoan Zheng, Kevin P Claffey, Kazunori Hoshino
We describe a novel mechanical characterization method that has directly measured the stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a key parameter that characterizes cancerous and normal cells. Atomic force microscopy or optical tweezers have been typically used for characterization of single cells with the measurable forces ranging from sub pN to a few hundred nN, which are not suitable for measurement of larger 3D cellular structures such as spheroids, whose mechanical characteristics have not been fully studied...
2017: PloS One
https://www.readbyqxmd.com/read/29165896/investigation-of-the-abnormal-nasal-aerodynamics-and-trigeminal-functions-among-empty-nose-syndrome-patients
#2
Chengyu Li, Alexander A Farag, Guillermo Maza, Sam McGhee, Michael A Ciccone, Bhakthi Deshpande, Edmund A Pribitkin, Bradley A Otto, Kai Zhao
BACKGROUND: Abnormal nasal aerodynamics or trigeminal functions have been frequently implicated in the symptomology of empty nose syndrome (ENS), yet with limited evidence. METHODS: Individual computed tomography (CT)-based computational fluid dynamics (CFD) was applied to 27 ENS patients to simulate their nasal aerodynamics and compared with 42 healthy controls. Patients' symptoms were confirmed with Empty Nose Syndrome 6-item Questionnaire (ENS6Q), 22-item Sino-Nasal Outcome Test (SNOT-22), and Nasal Obstruction Symptom Evaluation (NOSE) scores...
November 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29165798/weight-management-and-physical-activity-throughout-the-cancer-care-continuum
#3
Wendy Demark-Wahnefried, Kathryn H Schmitz, Catherine M Alfano, Jennifer R Bail, Pamela J Goodwin, Cynthia A Thomson, Don W Bradley, Kerry S Courneya, Christie A Befort, Crystal S Denlinger, Jennifer A Ligibel, William H Dietz, Melinda R Stolley, Melinda L Irwin, Marcas M Bamman, Caroline M Apovian, Bernardine M Pinto, Kathleen Y Wolin, Rachel M Ballard, Andrew J Dannenberg, Elizabeth G Eakin, Matt M Longjohn, Susan D Raffa, Lucile L Adams-Campbell, Joanne S Buzaglo, Sharyl J Nass, Greta M Massetti, Erin P Balogh, Elizabeth S Kraft, Anand K Parekh, Darshak M Sanghavi, G Stephen Morris, Karen Basen-Engquist
Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum...
November 22, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29165736/the-spartacus-trial-controversies-and-unresolved-issues
#4
Felix Beuschlein, Paolo Mulatero, Evelyn Asbach, Silvia Monticone, Cristiana Catena, Leonardo A Sechi, Michael Stowasser
Adrenal vein sampling (AVS) is considered the gold standard for the differential diagnosis in patients with primary aldosteronism (PA). The distinction between unilateral and bilateral disease dictates the targeted therapeutic approach with surgery for aldosterone producing adenomas and medical therapy for patients with bilateral hyperplasia. Thereby, this diagnostic step is crucial in clinical care. As AVS is an invasive, not well standardized procedure that is restricted to few specialized centers, several attempts have been made to simplify diagnostic algorithms...
November 17, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29165720/-relationship-strain-parkinson-s-disease-gender-specific-distress-of-partners-of-patients-with-parkinson-s-disease
#5
Christoph Braukhaus, Uwe Jahnke, Tanja Zimmermann
A Parkinson's disease is attended by high strain for the patients and an obvious loss of relationship functioning. Partners of patients (N=110) were evaluated via self-assessment in terms of own depression (PHQ-9), own fear of progression (PA-F-P-KF), relationship quality (PFB) as well as perceived deficits in everyday life and nonverbal communication. 26% of women and 11% of men showed depression scores, 51% of women and 41% of men dysfunctional fear of progression and about 60% were unsatisfied with their relationship...
November 17, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29165626/the-influence-of-physical-activity-and-sedentary-behavior-on-living-to-age-85-years-without-disease-and-disability-in-older-women
#6
Eileen Rillamas-Sun, Michael J LaMonte, Kelly R Evenson, Cynthia A Thomson, Shirley A Beresford, Mathilda C Coday, Todd M Manini, Wenjun Li, Andrea Z LaCroix
Background: Whether physical activity (PA) and sedentary behavior influence the odds of women living to age 85 years without chronic disease or disability is not well described. Methods: Participants of the Women's Health Initiative (n=49,612) were categorized based on health status by age 85 years: 1) lived without developing major chronic disease or mobility disability ("healthy"); 2) lived and developed mobility disability with or without disease; 3) lived and developed major chronic disease, but not mobility disability; and 4) died before their 85 th birth year...
November 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29165381/factors-associated-with-the-need-for-and-the-impact-of-extracorporeal-membrane-oxygenation-in-children-with-congenital-heart-disease-during-admissions-for-cardiac-surgery
#7
Salvatore Aiello, Rohit S Loomba
INTRODUCTION: This study aimed to determine factors associated with the need for extracorporeal membrane oxygenation (ECMO) in children with congenital heart disease (CHD) during admission for cardiac surgery (CS). A secondary aim was to determine how ECMO impacted length, cost, and mortality of the admission. METHODS: Data from the Kids' Inpatient Database (KIDS) were utilized. Admissions with CHD under 18 years of age with cardiac surgery were included. Need for ECMO in these admissions was then identified...
November 22, 2017: Children
https://www.readbyqxmd.com/read/29165218/molecular-identification-of-trichuris-suis-and-trichuris-trichiura-eggs-in-human-populations-from-thailand-lao-pdr-and-myanmar
#8
Issarapong Phosuk, Oranuch Sanpool, Tongjit Thanchomnang, Lakkhana Sadaow, Rutchanee Rodpai, Witthaya Anamnart, Penchom Janwan, Adulsak Wijit, Sakhone Laymanivong, Win Pa Pa Aung, Pewpan M Intapan, Wanchai Maleewong
Trichuris trichiura is a soil-transmitted helminth infecting human populations globally. Human cases caused by Trichuris suis and Trichuris vulpis have also been reported. Molecular identifications of Trichuris species infecting human populations in Lao PDR and Myanmar are lacking. Here, we explored molecular data obtained from Trichuris eggs recovered from human fecal samples from these countries and compared these with new and existing data from Thailand. Nuclear ribosomal DNA (18S and ITS2) sequences were amplified from Trichuris eggs and sequenced...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165128/associations-between-accelerometer-measured-physical-activity-and-body-fatness-in-school-aged-children
#9
Aleš Gába, Josef Mitáš, Lukáš Jakubec
BACKGROUND: The main aim of the study was to examine the cross-sectional associations between objectively measured physical activity (PA) and body fatness in 7-12-year-old children. METHODS: We performed an analysis of 365 children (209 girls). Participant recruitment was performed in eight randomly selected elementary schools in cities and towns with various numbers of inhabitants. The body composition analysis was performed according to a multi-frequency bioelectrical impedance analysis; PA was monitored using an accelerometer...
April 28, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165018/efficacy-of-an-individually-tailored-internet-mediated-physical-activity-intervention-in-older-adults-a-randomized-controlled-trial
#10
Taylor W Rowley, Elizabeth K Lenz, Ann M Swartz, Nora E Miller, Hotaka Maeda, Scott J Strath
OBJECTIVE: This study determined the effectiveness of an individually tailored, Internet-mediated physical activity (PA) intervention for increasing walking behavior in inactive older adults. METHOD: This 12-week randomly controlled intervention divided participants ( N = 170) into three groups: control (CON, n = 51), pedometer only (PED, n = 62), and an individually tailored, Internet-mediated pedometer (TI-PED, n = 57) group. The PED group was instructed to increase weekly step count by 10% until 10,000 steps per day was achieved...
October 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164848/static-capacitive-pressure-sensing-using-a-single-graphene-drum
#11
Dejan Davidovikj, Paul H Scheepers, Herre S J van der Zant, Peter Gerard Steeneken
To realize nanomechanical graphene-based pressure sensors, it is beneficial to have a method to electrically readout the static displacement of a suspended graphene membrane. Capacitive readout, typical in micro-electro-mechanical systems (MEMS), gets increasingly challenging as one starts shrinking the dimensions of these devices, since the expected responsivity of such devices is below 0.1 aF/Pa. To overcome the challenges of detecting small capacitance changes, we design an electrical readout device fabricated on top of an insulating quartz substrate, maximizing the contribution of the suspended membrane to the total capacitance of the device...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29164820/dual-ppar%C3%AE-%C3%AE-agonist-saroglitazar-improves-liver-histopathology-and-biochemistry-in-experimental-nash-models
#12
Mukul R Jain, Suresh R Giri, Bibhuti Bhoi, Chitrang Trivedi, Akshyaya Rath, Rohan Rathod, Ramchandra Ranvir, Shekhar Kadam, Hiren Patel, Prabodha Swain, Sib Sankar Roy, Nabanita Das, Eshani Karmakar, Walter Wahli, Pankaj R Patel
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common clinico-pathological conditions that affect millions of patients worldwide. In this study, the efficacy of saroglitazar, a novel PPARα/γ agonist, was assessed in models of NAFLD/NASH. METHODS & RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFα,IL1β and IL6)...
November 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164497/identifying-motives-of-midlife-black-triathlete-women-using-survey-transformation-to-guide-qualitative-inquiry
#13
Candace S Brown, Kevin S Masters, Amy G Huebschmann
Demonstrating health disparities related to race, age, and gender, older Black women (BW) are the most sedentary demographic group in the United States. Increasing PA in mid-life is important, as it improves health as BW age into their later years. Advancing our understanding of the exercise motives of BW triathletes presents a "reverse engineering" opportunity to identify motives that could influence sedentary mid-life BW to increase their activity. The purposes of this study were to: (a) utilize an innovative survey transformation method to adapt a measure developed primarily in Caucasian males, i...
November 22, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/29164375/patient-reported-physical-activity-and-the-association-with-health-related-quality-of-life-in-head-and-neck-cancer-survivors
#14
Annette J van Nieuwenhuizen, Laurien M Buffart, Cornelia F van Uden-Kraan, Lilly-Ann van der Velden, Martin Lacko, Johannes Brug, C René Leemans, Irma M Verdonck-de Leeuw
PURPOSE: This study aimed to assess patient-reported levels of physical activity (PA) and its associations with health-related quality of life (HRQoL) adjusted for important demographic, lifestyle-related, and clinical factors, among head and neck (HNC) survivors. METHODS: This cross-sectional study included 116 HNC survivors. PA was assessed with the Physical Activity Scale for the Elderly (PASE) and HRQoL with the EORTC-QLQ-C30 and EORTC-HN35. Associations were studied using univariable and multivariable regression analyses...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29163743/comparison-of-endovascular-treatment-with-intravenous-thrombolysis-for-isolated-m2-segment-of-middle-cerebral-artery-occlusion-in-acute-ischemic-stroke
#15
Adnan I Qureshi, Muhammad A Saleem, Emrah Aytac
Background: The benefit of endovascular treatment for distal large artery ischemic occlusions such as M2 segment of middle cerebral artery is not clear. Methods: We retrospectively analyzed data from 51 subjects who had an isolated M2 segment occlusion on baseline computed tomographic (CT) angiogram who were randomized to either intravenous (IV) recombinant tissue plasminogen activator (rt-PA) followed by endovascular treatment or IV rt-PA alone in a multicenter trial...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29163361/girls-with-a-history-of-premature-adrenarche-have-advanced-growth-and-pubertal-development-at-the-age-of-12-years
#16
Jani Liimatta, Pauliina Utriainen, Raimo Voutilainen, Jarmo Jääskeläinen
Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of mostly full-term and appropriate for gestational age-born 43 PA (36 girls) and 63 control children (52 girls) were analyzed prospectively. Children examined first at the mean age of 7.6 years were reexamined at the mean age of 12.0 years. Results: The PA girls but not the boys were taller and had higher body mass index (BMI) than the controls...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163114/interaction-between-bdnf-polymorphism-and-physical-activity-on-inhibitory-performance-in-the-elderly-without-cognitive-impairment
#17
Anne Canivet, Cédric T Albinet, Montserrat Rodríguez-Ballesteros, Christian Chicherio, Delphine Fagot, Nathalie André, Michel Audiffren
Background: In the elderly, physical activity (PA) enhances cognitive performances, increases brain plasticity and improves brain health. The neurotrophic hypothesis is that the release of brain-derived neurotrophic factor (BDNF), which is implicated in brain plasticity and cognition, is triggered by PA because motoneurons secrete BDNF into the bloodstream during exercise. Individual differences in cognitive performance may be explained by individual differences in genetic predisposition. A single nucleotide polymorphism on the BDNF gene, BDNFVal66Met, affects activity-dependent BDNF secretion...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29162544/immunostimulation-and-yellow-head-virus-yhv-disease-resistance-induced-by-a-lignin-based-pulping-by-product-in-black-tiger-shrimp-penaeus-monodon-linn
#18
Prapansak Srisapoome, Kaoru Hamano, Isao Tsutsui, Kenji Iiyama
Yellow head virus (YHV) is classified as one of the most serious pathogens causing a harmful disease in many penaeids, especially black tiger shrimp (Penaeus monodon), with high economic loss. To determine a potent and practical prophylactic strategy for controlling this disease, the toxicity of the by-product kraft lignin and its ability to control severe YHV infection were investigated in juvenile black tiger shrimp (15.9 ± 1.2 g body weight). The median lethal dosage at 96 h (96-hrs LD50) of lignin in shrimp was 297 mg/L...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29162447/co-administration-of-liposomal-fasudil-and-tissue-plasminogen-activator-ameliorated-ischemic-brain-damage-in-occlusion-model-rats-prepared-by-photochemically-induced-thrombosis
#19
Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
Delivery of neuroprotectants with liposomes has been shown to be effective for the treatment of ischemic stroke. We have recently revealed that intravenous administration of liposomal fasudil (Fasudil-Lip), a Rho-kinase inhibitor, prior to thrombolysis with tissue plasminogen activator (t-PA) can extend the narrow therapeutic time window (TTW) of t-PA. In the present study, we examined the influence of t-PA treatment on liposomal accumulation into the ischemic region and cerebroprotective effect of combined treatment with Fasudil-Lip and t-PA performed at the same timing after the onset of ischemia in middle cerebral artery occlusion (MCAO) prepared by photochemically induced thrombosis...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29162291/the-efficacy-of-self-disinfecting-bedrail-covers-in-an-intensive-care-unit
#20
Lisa M Esolen, Lokendra Thakur, Abraham J Layon, Thomas A Fuller, Deni-Jo Harrington, Kunal Jha, Subhashinie Kariyawasam
BACKGROUND: Hospital surfaces are considered important vectors in the spread of nosocomial pathogens. This study evaluated microbial counts on novel antimicrobial bedrail covers over a 2-week period in a critical care environment. METHODS: Disposable bedrail covers (Aionx Inc, Hershey, PA) made of a copper and silver polymer and capable of conducting an imperceptible surface potential, were installed in a case-control manner on a series of occupied intensive care unit beds...
November 19, 2017: American Journal of Infection Control
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