keyword
https://read.qxmd.com/read/38476799/comparison-of-laparoscopic-intraperitoneal-onlay-mesh-ipom-hernioplasty-with-laparoscopic-ipom-plus-our-initial-experience-in-pakistan
#1
JOURNAL ARTICLE
Fahad Yasin, Ali Abaid, Ahsan Shafiq, Muhammad Umar, Wasim Hayat Khan, Mahmood Ayyaz, Usman Ismat Butt
Objectives Laparoscopic intraperitoneal onlay mesh hernioplasty (IPOM) for ventral hernias has been used for a long time. However, there have been some issues associated with it, thereby leading to the introduction of a new technique that involves laparoscopic closure of the fascial defect with suture followed by intraperitoneal onlay mesh placement (IPOM-Plus). We carried out this study to compare the outcome of laparoscopic IPOM with fascial defect closure versus without defect closure in midline ventral hernia repair in terms of recurrence...
February 2024: Curēus
https://read.qxmd.com/read/38475706/a-road-map-for-the-management-of-a-pregnancy-complicated-by-maternal-bladder-exstrophy
#2
JOURNAL ARTICLE
A Hosiani, M E Smet, R Nayyar
Bladder exstrophy (BE) is a congenital genito-urinary malformation where there is a defect in the abdominal wall resulting in a protruding open bladder with exposed mucosa (Resnik R.P. et al. Creasy and Resnik's maternal-fetal medicine: principles and practice. Elsevier, 2019). Several reconstructive procedures are required to correct the anomalies, resulting in an ileal conduit which is an alternate urinary reservoir reconstructed from the terminal ileum (Madersbacher S, et al. J Urol 169(3):985-90, 2003)...
March 12, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38471700/loeys-dietz-syndrome-and-goldenhar-syndrome-unveiled-together
#3
JOURNAL ARTICLE
Henuka Verma, Prashant Kumar Verma, Nikhil Rajvanshi, Nowneet Kumar Bhat
Haemifacial microsomia is an asymmetrical congenital tissue malformation developed from the first and second branchial arches with or without multi-system involvement. Alternatively recognised as Goldenhar syndrome or oculoauriculovertebral spectrum (OAVS), it is an aetiologically heterogeneous group of disorders showing dominant trends in inheritable form.We present a case of a boy in early childhood with concomitant craniofacial features of craniofacial microsomia with Loeys-Dietz syndrome. He had a unilateral hypoplastic face, asymmetrical ear malformations and multiple preauricular tags with epibulbar dermoid (features suggestive of Goldenhar syndrome)...
March 12, 2024: BMJ Case Reports
https://read.qxmd.com/read/38471643/transcatheter-myotomy-to-reduce-left-ventricular-outflow-obstruction
#4
JOURNAL ARTICLE
Adam B Greenbaum, Hiroki A Ueyama, Patrick T Gleason, Jaffar M Khan, Christopher G Bruce, Rim N Halaby, Toby Rogers, George S Hanzel, Joe X Xie, Isida Byku, Robert A Guyton, Kendra J Grubb, John C Lisko, Nikoloz Shekiladze, Errol K Inci, Elizabeth A Grier, Gaetano Paone, James M McCabe, Robert J Lederman, Vasilis C Babaliaros
BACKGROUND: Left ventricular outflow tract (LVOT) obstruction is a source of morbidity in hypertrophic cardiomyopathy (HCM) and a life-threatening complication of transcatheter mitral (TMVR) and aortic valve replacement (TAVR). Available surgical and transcatheter approaches are limited by high surgical risk, unsuitable septal perforators, and heart block requiring permanent pacemakers. OBJECTIVES: We report the initial experience of a novel transcatheter electrosurgical procedure developed to mimic surgical myotomy...
February 16, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38466355/a-bmp-controlled-metabolic-epigenetic-signaling-cascade-directs-midfacial-morphogenesis
#5
JOURNAL ARTICLE
Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A Hallett, Lorin E Olson, Yuji Mishina
Craniofacial anomalies, especially midline facial defects, are among the most common birth defects in patients associated with increased mortality or require lifelong treatment. During mammalian embryogenesis, specific instructions arising at genetic, signaling, and metabolic levels are important for stem cell behaviors and fate determination, but how these functionally relevant mechanisms are coordinated to regulate craniofacial morphogenesis remain unknown. Here, we report that BMP signaling in cranial neural crest cells (CNCCs) is critical for glycolytic lactate production and subsequent epigenetic histone lactylation, thereby dictating craniofacial morphogenesis...
March 11, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38450283/a-selective-defect-in-the-glial-wedge-as-part-of-the-neuroepithelium-disruption-in-hydrocephalus-development-in-the-mouse-hyh-model-is-associated-with-complete-corpus-callosum-dysgenesis
#6
JOURNAL ARTICLE
Luis-Manuel Rodríguez-Pérez, Javier López-de-San-Sebastián, Isabel de Diego, Aníbal Smith, Ruth Roales-Buján, Antonio J Jiménez, Patricia Paez-Gonzalez
INTRODUCTION: Dysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital hydrocephalus and agenesis of the corpus callosum when they coappear during neurodevelopment persist unclear. In this work, the mechanistic relationship between both disorders is investigated in the hyh mouse model for congenital hydrocephalus, which also develops agenesis of the corpus callosum...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38449992/spontaneous-perforation-of-meckel-s-diverticulum-in-a-young-adult-male-a-case-report-and-review-of-the-literature
#7
Mahmoud S Aly, Zohaib Jamal
Meckel's diverticulum, a congenital defect that affects about 2% of the population, is a remnant of the embryologic vitelline duct. Perforated Meckel's diverticulum, a rare consequence of an already rare disease process, frequently presents and is diagnosed as a perforated appendix. We report a case of a 28-year-old male who presented with a two-day history of right-sided lower abdominal pain associated with nausea. The abdominal examination revealed a soft, nondistended abdomen with tenderness in the right iliac fossa...
February 2024: Curēus
https://read.qxmd.com/read/38447690/bilateral-whisker-representations-in-the-primary-somatosensory-cortex-in-robo3cko-mice-are-reflected-in-the-primary-motor-cortex
#8
JOURNAL ARTICLE
Vassiliy Tsytsarev, Céline Plachez, Shuxin Zhao, Daniel H O'Connor, Reha S Erzurumlu
In Robo3cKO mice, midline crossing defects of the trigeminothalamic projections from the trigeminal principal sensory nucleus result in bilateral whisker maps in the somatosensory thalamus and consequently in the face representation area of the primary somatosensory (S1) cortex (Renier et al., 2017; Tsytsarev et al., 2017). We investigated whether this bilateral sensory representation in the whisker-barrel cortex is also reflected in the downstream projections from the S1 to the primary motor (M1) cortex. To label these projections, we injected anterograde viral axonal tracer in S1 cortex...
March 4, 2024: Neuroscience
https://read.qxmd.com/read/38421079/smc1a-epilepsy-syndrome-clinical-data-from-a-large-international-cohort
#9
JOURNAL ARTICLE
Elisabetta Gibellato, Paola Cianci, Milena Mariani, Barbara Parma, Sylvia Huisman, Robert Śmigiel, Anne-Marie Bisgaard, Valentina Massa, Cristina Gervasini, Alex Moretti, Alessandro Cattoni, Andrea Biondi, Angelo Selicorni
SMC1A epilepsy syndrome or developmental and epileptic encephalopathy-85 with or without midline brain defects (DEE85, OMIM #301044) is an X-linked neurologic disorder associated with mutations of the SMC1A gene, which is also responsible for about 5% of patients affected by Cornelia de Lange syndrome spectrum (CdLS). Only described in female patients, SMC1A epilepsy syndrome is characterized by the onset of severe refractory epileptic seizures in the first year of life, global developmental delay, a variable degree of intellectual disability, and dysmorphic facial features not typical of CdLS...
February 29, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38393669/-endoscopic-endonasal-anterior-skull-base-surgery-presentation-of-a-monocentric-entity-profile
#10
JOURNAL ARTICLE
Lisa Schmitz, Christian S Betz, Katharina Stölzel
BACKGROUND: Extended endoscopic endonasal surgery (EEES) is an essential part of treatment of various pathologies of the anterior skull base. In addition to significant improvements in the quality of life of affected patients and a lower complication profile compared to open skull base surgery, the therapeutic results are comparable if the indications are correct. MATERIALS AND METHODS: Data of all endoscopic endonasal skull base procedures performed at the University Skull Base Center Hamburg under the direction of the Department of Otorhinolaryngology between June 2018 and November 2022 were retrospectively collected...
February 23, 2024: HNO
https://read.qxmd.com/read/38393191/scalp-closure-in-midline-cutis-aplasia-an-absolute-indication-for-preoperative-imaging
#11
JOURNAL ARTICLE
Harvey Chim, Christian Arcelona, Arun K Gosain
The ideal evaluation and treatment of aplasia cutis congenita remains disputed. We present a case of midline scalp cutis aplasia that healed by secondary intention, leaving an area of residual alopecia. There were no clinical indicators of an underlying calvarial defect. Tissue expansion of the scalp was done in preparation for scalp closure. However, on the removal of the expanders and scalp advancement, an unrecognized midline calvarial defect in which a scar tract of herniated dura was found. This resulted in a dural tear, repaired with minimal hemorrhage...
February 23, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38389767/surgical-management-of-sternal-tumours-a-decade-of-experience-from-a-tertiary-care-centre-in-india
#12
JOURNAL ARTICLE
Raj Kumar Joel, Santhosh Regini Benjamin, Vinay Murahari Rao, Thomas Alex Kodiatte, Birla Roy Gnanamuthu, Aamir Mohammad, Mallampati Sameer, Nishok David
Tumours of the sternum can be either primary or secondary with malignancy being the most common etiology. Wide local excision of these tumours results in a midline defect which pose a unique challenge for reconstruction. As limited data on the management of these tumours exists in the literature, we hereby report 14 consecutive patients who were treated at our institute between January 2009 to December 2020. Most of them were malignant with majority of them, 11 (78%) patients, with manubrial involvement requiring partial sternectomy...
March 2024: Indian Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38384523/a-new-classification-of-mandible-defects-and-condyle-changed-after-mandible-reconstruction-with-fff
#13
JOURNAL ARTICLE
Yaxi Wang, Guosheng Chen, Nuo Zhou, Xuanping Huang
OBJECTIVES: To explore a new classification of mandibular defects and changes in the preserved condyle after mandibular reconstruction with free fibular flap(FFF). STUDY DESIGN: We reviewed patients who underwent mandibular reconstruction with FFF from 2015 to 2021 and classified the mandibular defects into five categories: classⅠ(unilateral-mandibular excluding condyle), classⅡ(unilateral-mandibular including condyle), classⅢ(bilateral-mandibular excluding condyle), classⅣ(bilateral-mandibular including one condyle), and classⅤ(bilateral-mandibular including both condyles)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38379817/new-perspectives-on-assessment-and-understanding-of-the-patient-with-cranial-bone-defect-a-morphometric-and-cerebral-radiodensity-assessment
#14
JOURNAL ARTICLE
Arthur Maynart Pereira Oliveira, Almir Ferreira De Andrade, Leonardo Zumerkorn Pipek, Corrado Iaccarino, Andres M Rubiano, Robson Luis Amorim, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
BACKGROUND: Skull defects after decompressive craniectomy (DC) cause physiological changes in brain function and patients can have neurologic symptoms after the surgery. The objective of this study is to evaluate whether there are morphometric changes in the cortical surface and radiodensity of brain tissue in patients undergoing cranioplasty and whether those variables are correlated with neurological prognosis. METHODS: This is a prospective cohort with 30 patients who were submitted to cranioplasty and followed for 6 months...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38376330/dural-and-calvarial-metastasis-of-thyroid-follicular-carcinoma-mimicking-sindou-type-6-parafalcine-meningioma
#15
JOURNAL ARTICLE
Abdulkerim Gokoglu, Merdan Orunoglu, Murat Sakir Eksi, Vedat Arsa, Ahmet Selcuklu
Fifty-two years, NID type-2 diabetic female was admitted with progressive headache, enlarging, pulsatile midline mass, dizziness, and numbness of extremities. Physical examination revealed only hypoesthesia in the upper left extremity C7-dermatome. Preoperative computed tomography revealed eroded parafalcian dural mass and caused a round 7 cm calvarial defect over the superior sagittal sinus (SSS) and another left parietal 1.2 cm satellite mass. Magnetic resonance imaging revealed an extra-axial, diffuse heterogeneous gadolinium-enhanced, well-circumscribed lesion invading the SSS and Trolard veins (bilaterally)...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38366238/delphi-consensus-statement-for-understanding-and-managing-the-subcostal-hernia-subcostal-hernias-collaborative-report-scholar-study
#16
JOURNAL ARTICLE
S J Baig, G V Kulkarni, P Priya, M Y Afaque, J Bueno-Lledo, S Chintapatla, A de Beaux, J A Gandhi, M A Garcia Urena, T M Hammond, D Lomanto, R Liu, A Mehta, M Miserez, A Montgomery, S Morales-Conde, C Palanivelu, E M Pauli, S A Rege, Y Renard, M Rosen, D L Sanders, V K Singhal, D A J Slade, O J Warren, S Wijerathne
INTRODUCTION: Subcostal hernias are categorized as L1 based on the European Hernia Society (EHS) classification and frequently involve M1, M2, and L2 sites. These are common after hepatopancreatic and biliary surgeries. The literature on subcostal hernias mostly comprises of retrospective reviews of small heterogenous cohorts, unsurprisingly leading to no consensus or guidelines. Given the limited literature and lack of consensus or guidelines for dealing with these hernias, we planned for a Delphi consensus to aid in decision making to repair subcostal hernias...
February 16, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38344583/endoscopic-assisted-curettage-of-posterior-proximal-tibia-chondroblastoma-a-case-report-and-review-of-literature
#17
Hawra M Albaqali, Emad Alabsi, Mohammad S Alfehaid, Rasees F Alotaibi, Amani Joudeh
Chondroblastoma is a benign cartilage-producing bone lesion that characteristically occurs in the epiphyseal region of long bones. The most typical locations are the proximal humerus, proximal femur, distal femur, and proximal tibia. There is no medical treatment for the disease; classically, it must be treated by intralesional curettage and bone grafting. A 15-year-old female patient presented with chronic knee pain with no antecedent history of trauma. Clinical examination showed deep tenderness on maximum flexion and 15 degrees extension lag with full knee flexion...
January 2024: Curēus
https://read.qxmd.com/read/38327949/cervical-dermal-sinus-tract-a-case-report-and-comprehensive-literature-review
#18
Cristopher Ramirez-Loera, Víctor Hugo Galván Soto, Ricardo Martínez-Pérez, Armando S Ruiz-Treviño
The cervical and thoracic dermal sinuses are rare entities, conforming epithelium-lined tracts that extend from an opening in the skin through a corridor to the layers of the spinal cord. They are commonly detected in early childhood; however, adult reports are singularly rare, especially in cervical regions. We report a very unusual case of a 45-year-old Mexican female who developed progressive left-side weakness and dexterity suffered from childhood, getting worse in the last year. Physical examination revealed a soft, congenital round cystic lesion in the dorsal-midline skin at the level of C4-C5 vertebrae with no previous treatment received...
January 2024: Curēus
https://read.qxmd.com/read/38322172/defective-blastogenesis-of-postnatally-diagnosed-type-vi-sirenomelia-in-a-young-primigravida-a-case-report
#19
Mhd Mustafa Albitar, Mohamad Moamen Almouallem, Ahmad Mostafa Kanaan, Ieman Alawad
Sirenomelia is a rare lethal multi-systemic birth malformation in which the two lower limbs are replaced with a rotated single midline tail-like limb. Several hypotheses try to explain this syndrome, with the most prominent theories being the "vascular steal hypothesis" and the "defective blastogenesis hypothesis." We report a case of a baby with sirenomelia who had a single femur and a single tibia, which classify the case as type VI on Stocker and Heifetz classification. The only risk factor in our case is young maternal age...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38321728/pituitary-stalk-interruption-syndrome-analysis-of-response-to-growth-hormone-therapy
#20
JOURNAL ARTICLE
Raghuraman Ravichandran, Uma K Saikia, Ashok K Bhuyan, Abhamoni Baro
OBJECTIVE: To analyse the clinical and radiological characteristics of pituitary stalk interruption syndrome (PSIS). METHODS: A retrospective analysis of confirmed cases of PSIS was performed. The development of new pituitary hormonal deficiencies and response to recombinant human growth hormone (rhGH) therapy were assessed during follow-up. RESULTS: This study included 14 children (10 boys) of PSIS with median (range) age of 12.15 years (2 months - 18 years)...
February 15, 2024: Indian Pediatrics
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