Brian M Wei, Lindy P Fox, Benjamin H Kaffenberger, Abraham M Korman, Robert G Micheletti, Arash Mostaghimi, Megan H Noe, Misha Rosenbach, Kanade Shinkai, Jason H Kwah, Elizabeth J Phillips, Jean L Bolognia, William Damsky, Caroline A Nelson
Drug-induced hypersensitivity syndrome (DiHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS), is a severe cutaneous adverse reaction (SCAR) characterized by an exanthem, fever, and hematologic and visceral organ involvement. Anticonvulsants, antibiotics, and allopurinol are the most common triggers. The pathogenesis involves a complex interplay between drugs, viruses, and the immune system primarily mediated by T-cells. DiHS/DRESS typically presents with a morbilliform eruption 2-6 weeks after drug exposure, and is associated with significant morbidity, mortality, and risk of relapse...
July 27, 2023: Journal of the American Academy of Dermatology