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https://www.readbyqxmd.com/read/29877623/nutrient-optimization-reduces-phosphorylation-and-hydroxylation-level-on-an-fc-fusion-protein-in-a-cho-fed-batch-process
#1
Ye Hou, Hang Su, Zhiying Luo, Mingying Li, Xiaonan Ma, Ningning Ma
Phosphorylation and hydroxylation are post translational modifications (PTMs) rarely observed or reported in biopharmaceuticals. While developing a stable CHO cell line and a fed-batch process to produce a biosimilar dulaglutide, a GLP1-Fc fusion protein, we identified both serine phosphorylation and lysine hydroxylation. While the innovator dulaglutide contains less than 2% phosphorylated and only approximately 6.5% hydroxylated GLP1-Fc molecules, the clones that we obtained in the platform fed-batch process had approximately 20% phosphorylated and 25% hydroxylated GLP1-Fc molecules...
June 7, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29676875/-faster-aspart-insulin-fiasp%C3%A2
#2
N Paquot, A J Scheen
Fast-acting insulin aspart (faster aspart), commercialized under the trade name of Fiasp®, is insulin aspart in a new formulation aiming to mimic the physiologic prandial insulin release more closely than currently available rapid-acting insulin products. Fiasp® is insulin aspart (NovoRapid®) in which two excipients (L-arginine and niacinamide) have been added, L-arginine serving as a stabilising agent, while niacinamide being responsible for accelerated initial absorption after subcutaneous administration...
April 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29672269/garlic-allium-sativum-increases-sirt1-and-sirt2-gene-expressions-in-the-kidney-and-liver-tissues-of-stz-and-stz-niacinamide-induced-diabetic-rats
#3
Zahra Arab Sadeghabadi, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Roohollah Mohseni
BACKGROUND: Diabetic nephropathy and liver damage are important complications of diabetes mellitus (DM). Various factors, such as sirtuins (silent information regulators or SIRTs) are associated with these complications. Sirtuins are a family of NAD+-dependent proteins, and seven types of these can be found in mammalians. In this study, we evaluated the effects of aqueous garlic extract (G) on the expressions of SIRT1 and SIRT2 genes in the kidney and liver tissues of rats with types 1 and 2 diabetes...
April 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29665936/-metabolic-characteristics-of-leucocyte-deplated-and-suspended-rbc-produced-by-using-lipid-whole-blood-during-routine-storage
#4
Jun-Hong Yang, Yu-Lin Jiang, Yi-Feng Liu, Zhi-Qian Zhang, Chang-Li Zhong, Nian Wang, Fei-Hu Ji, Qian-Ni Jin, Xiang-Sen Ye, Ting-Mei Chen
OBJECTIVE: To investigate the differences of metabolic pathways of leucocyte-deplated RBCs prepared by using lipid whole blood and nomal blood during routine storage so as to provide some reference for clinical blood use. METHODS: Twenty U whole blood from 20 donors, including 10 U lipid blood and 10 U normal whole blood, were selected for preparing leukodepleted red blood cells, red blood cells were taken from storage bags on day 0, 14 and 35, respectively. Metabolites in the red blood cells were analyzed, red blood cell metabolic extracts were detected by UPLC-MS/MS...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29564872/reducing-the-oral-isotretinoin-skin-side-effects-efficacy-of-8-omega-ceramides-hydrophilic-sugars-5-niacinamide-cream-compound-in-acne-patients
#5
Maria V Cannizzaro, Annunziata Dattola, Virginia Garofalo, Ester Del Duca, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment...
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29552273/are-natural-ingredients-effective-in-the-management-of-hyperpigmentation-a-systematic-review
#6
REVIEW
Jasmine C Hollinger, Kunal Angra, Rebat M Halder
BACKGROUND: Hyperpigmentation disorders are commonly encountered in dermatology clinics. Botanical and natural ingredients have gained popularity as alternative depigmenting products. OBJECTIVE: We sought to review clinical studies evaluating the use of different natural products in treating hyperpigmentation so clinicians are better equipped to educate their patients. Specific ingredients reviewed include azelaic acid, aloesin, mulberry, licorice extracts, lignin peroxidase, kojic acid, niacinamide, ellagic acid, arbutin, green tea, turmeric, soy, and ascorbic acid...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29533537/the-protective-effect-of-niacinamide-on-cho-aa8-cell-line-against-ultraviolet-radiation-in-the-context-of-main-cytoskeletal-proteins
#7
Magdalena Izdebska, Marta Hałas-Wiśniewska, Iwona Adamczyk, Ismena Lewandowska, Iga Kwiatkowska, Maciej Gagat, Alina Grzanka
BACKGROUND: Niacinamide is a stable and water-soluble form of vitamin B3, a valuable and versatile cosmetic ingredient, which is well absorbed and tolerated by the skin. A large body of literature has reported on the antioxidant and cell repair properties of niacinamide. Therefore, it has been shown to be useful in the protection of the skin against ultraviolet B (UVB) radiation and free radicals. Despite numerous hypotheses on the mechanism of vitamin B3, its protective effects have not yet been fully elucidated...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29350822/resveratrol-suppresses-rotenone-induced-neurotoxicity-through-activation-of-sirt1-akt1-signaling-pathway
#8
Hui Wang, Xiaoguang Dong, Zengxun Liu, Shaowei Zhu, Haili Liu, Wenchuang Fan, Yanlai Hu, Tao Hu, Yonghui Yu, Yizhao Li, Tianwei Liu, Chengjia Xie, Qing Gao, Guibao Li, Jing Zhang, Zhaoxi Ding, Jinhao Sun
Rotenone is a common pesticide and has been reported as one of the risk factors for Parkinson disease. Rotenone can cause neuronal death or apoptosis through inducing oxidative injury and inhibiting mitochondrial function. As a natural polyphenolic compound, resveratrol possesses the antioxidant capacity and neuroprotective effect. However, the mechanism underlying the neuroprotective effect of resveratrol against rotenone-induced neurotoxicity remains elusive. Here, we treated PC12 cells with rotenone to induce neurotoxicity, and the neurotoxic cells were subjected to resveratrol treatment...
January 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29127752/-faster-insulin-aspart-a-new-prandial-insulin-analogue
#9
REVIEW
Milan Flekač
Preventing postprandial blood glucose excursions is one of the most challenging aspects of achieving adequate control, especially in patients with better long-term compensation of diabetes. Contemporary prandial insulin analogues that have more favorable properties than human insulin in terms of accelerated absorption, earlier onset of action and shorter duration of action are still significantly slower than endogenous insulin in healthy individuals. Fast-acting insulin aspart (FIAsp - faster aspart) is insulin aspart enriched with two excipients, of which niacinamide is responsible for accelerating absorption after subcutaneous administration...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28990239/tacrolimus-therapy-for-dermal-arteritis-of-the-nasal-philtrum-refractory-to-surgery-and-anti-inflammatory-therapy-doxycycline-niacinamide-and-topical-fluocinolone-in-a-dog
#10
Frane Banovic, Carmen Jerry, Elizabeth Howerth
BACKGROUND: Dermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs. OBJECTIVE: To describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog. ANIMAL: A 9-year-old, intact male German shorthair pointer dog was presented with well-demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage...
February 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/28979656/treatment-of-actinic-purpura
#11
REVIEW
Roger I Ceilley
Mature skin is prone to bruising, resulting in a condition known as actinic purpura, characterized by unsightly ecchymosis and purple patches. Similar to other skin conditions, the incidence of actinic purpura increases with advancing age and occurs with equal frequency among men and women. The unsightly appearance of actinic purpura may be a source of emotional distress among the elderly. A new product has been formulated specifically for the treatment of actinic purpura. This product contains retinol, α-hydroxy acids, arnica oil, ceramides, niacinamide, and phytonadione, which effectively treat actinic purpura by improving local circulation, thickening the skin, and repairing the skin barrier...
June 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28940145/pharmacological-properties-of-faster-acting-insulin-aspart
#12
REVIEW
Torben Biester, Olga Kordonouri, Thomas Danne
PURPOSE OF REVIEW: Faster aspart is a new formulation of insulin aspart (IAsp) produced by adding the excipients niacinamide and L-arginine. As this new, "ultra-rapid insulin" is available in the EU-market and Canada, the pharmacokinetic and pharmacodynamics data is summarized. RECENT FINDINGS: Faster aspart shows an earlier onset of appearance of insulin in the bloodstream after subcutaneous administration and an earlier onset of glucose-lowering action and a higher glycemic effect within the first 30 min...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28923651/high-resolution-magic-angle-spinning-nuclear-magnetic-resonance-spectroscopy-for-the-metabolic-assessment-of-acute-rejection-after-cardiac-transplantation-in-rats
#13
C W Lee, J S Lee, C W Woo, S Kim
PURPOSE: To evaluate the potential of high-resolution magic angle spinning (HR-MAS) (1)H nuclear magnetic resonance (NMR) spectroscopy for metabolite characterization and the differentiation of acute rejection after heart transplantation in rat models. METHODS: We transplanted syngeneic heart grafts from Lewis rats (n = 4) and allogeneic heart grafts from F344 rats (n = 4) heterotopically into Lewis recipients. On day 7 postoperatively, the transplanted hearts were harvested for ex vivo (1)H NMR spectroscopy and HR-MAS (1)H NMR spectroscopy...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28627707/tremella-fuciformis-polysaccharide-suppresses-hydrogen-peroxide-triggered-injury-of-human-skin-fibroblasts-via-upregulation-of-sirt1
#14
Tao Shen, Chao Duan, Beidong Chen, Meng Li, Yang Ruan, Danni Xu, Doudou Shi, Dan Yu, Jian Li, Changtao Wang
Tremella fuciformis polysaccharide (TFPS), which is the extract of Tremella fuciformis Berk, has previously been demonstrated to exhibit potent anti‑oxidative, anti‑inflammatory and anti‑aging effects. However, the mechanisms underlying these protective and therapeutic effects remain to be elucidated. The aim of the present study was to investigate the protective effects of TFPS on hydrogen peroxide‑induced injury of human skin fibroblasts and to elucidate the aforementioned underlying mechanisms...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28556616/fast-acting-insulin-aspart-in-japanese-patients-with-type-1-diabetes-faster-onset-higher-early-exposure-and-greater-early-glucose-lowering-effect-relative-to-insulin-aspart
#15
Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen, Hanne Haahr
INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing. The present study compared the pharmacokinetic/pharmacodynamic characteristics of faster aspart vs IAsp in Japanese patients with type 1 diabetes. MATERIALS AND METHODS: In a randomized, double-blind, cross-over design, 43 participants were given faster aspart and IAsp (0...
March 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28512843/assessment-of-the-efficacy-and-safety-of-a-new-complex-skin-cream-in-asian-women-a-controlled-clinical-trial
#16
Yu Seok Jung, Ji Hae Lee, Jung Min Bae, Dong Won Lee, Gyong Moon Kim
BACKGROUND: Medical products such as hydroquinone and tretinoin have been widely used to treat various types of skin hyperpigmentation. However, these products are limited in daily use given their adverse effects. Other alternative agents with fewer adverse side effects have been developed. However, single agents often do not produce satisfactory results. AIMS: To evaluate the efficacy and safety of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid...
June 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28501790/obesity-aggravates-toxic-effect-of-bpa-on-spermatogenesis
#17
Weiyue Hu, Tianyu Dong, Lingling Wang, Quanquan Guan, Ling Song, Daozhen Chen, Zuomin Zhou, Minjian Chen, Yankai Xia, Xinru Wang
Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We firstly analyzed the interaction on semen volume, sperm count per ejaculate, sperm concentration and sperm motility in 357 men, and found that urinary BPA concentration was significantly correlated with sperm count per ejaculate in obese men (β=-34...
August 2017: Environment International
https://www.readbyqxmd.com/read/28403270/evidence-for-anti-aging-south-korean-cosmeceuticals
#18
Ellinor R Quay, Yunyoung C Chang, Emmy Graber
<p>As the market for South Korean skin care products grows in the U.S. and worldwide, consumers will increasingly seek advice from dermatologists regarding their efficacy. In this paper, the evidence behind the anti-aging and skin whitening activity of ingredients in the most popular South Korean skin care products was reviewed and critically evaluated. Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea. The top selling products and their ingredients were then identified from individual brand websites...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28182848/simultaneous-determination-of-eight-b-vitamins-in-rat-intestinal-perfusate-to-identify-effects-of-osmotic-pressures-on-absorptions
#19
Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun
A rapid and accurate HPLC-DAD method was developed and validated to simultaneously determine eight B-vitamins (VBs, namely thiamine, riboflavin, niacinamide, calcium pantothenic, pyridoxine, biotin, folic acid and cyanocobalamin) and phenolsulfonphthalein in rat intestinal perfusate. Chromatographic separation was achieved using an Inertsil ODS-3 column (250 × 4.6 mm i.d., 5 μm) at a temperature of 40°C. Gradient elution mode was applied at the flow rate of 1.0 mL/min with the mobile phase of acetonitrile-30 mm K2 HPO4 (pH 5...
September 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28165180/faster-acting-insulin-aspart-provides-faster-onset-and-greater-early-exposure-vs-insulin-aspart-in-children-and-adolescents-with-type-1-diabetes-mellitus
#20
Maryam Fath, Thomas Danne, Torben Biester, Lars Erichsen, Olga Kordonouri, Hanne Haahr
BACKGROUND: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM: This randomized, double-blind, 2-period crossover trial investigated the pharmacological properties of faster aspart vs IAsp in 12 children (6-11 years), 13 adolescents (12-17 years), and 15 adults (18-64 years) with type 1 diabetes mellitus...
December 2017: Pediatric Diabetes
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