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https://www.readbyqxmd.com/read/28627707/tremella%C3%A2-fuciformis-polysaccharide-suppresses-hydrogen-peroxide-triggered-injury-of-human-skin-fibroblasts-via-upregulation-of-sirt1
#1
Tao Shen, Chao Duan, Beidong Chen, Meng Li, Yang Ruan, Danni Xu, Doudou Shi, Dan Yu, Jian Li, Changtao Wang
Tremella fuciformis polysaccharide (TFPS), which is the extract of Tremella fuciformis Berk, has previously been demonstrated to exhibit potent anti‑oxidative, anti‑inflammatory and anti‑aging effects. However, the mechanisms underlying these protective and therapeutic effects remain to be elucidated. The aim of the present study was to investigate the protective effects of TFPS on hydrogen peroxide‑induced injury of human skin fibroblasts and to elucidate the aforementioned underlying mechanisms...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28556616/fast-acting-insulin-aspart-in-japanese-patients-with-type-1-diabetes-faster-onset-higher-early-exposure-and-greater-early-glucose-lowering-effect-relative-to-insulin-aspart
#2
Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen, Hanne Haahr
AIMS/INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing. This study compared the pharmacokinetic/pharmacodynamic characteristics of faster aspart vs. IAsp in Japanese patients with type 1 diabetes (T1D). MATERIALS AND METHODS: In a randomized, double-blind, crossover design, 43 participants were administered faster aspart and IAsp (0...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28512843/assessment-of-the-efficacy-and-safety-of-a-new-complex-skin-cream-in-asian-women-a-controlled-clinical-trial
#3
Yu Seok Jung, Ji Hae Lee, Jung Min Bae, Dong Won Lee, Gyong Moon Kim
BACKGROUND: Medical products such as hydroquinone and tretinoin have been widely used to treat various types of skin hyperpigmentation. However, these products are limited in daily use given their adverse effects. Other alternative agents with fewer adverse side effects have been developed. However, single agents often do not produce satisfactory results. AIMS: To evaluate the efficacy and safety of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid...
May 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28501790/obesity-aggravates-toxic-effect-of-bpa-on-spermatogenesis
#4
Weiyue Hu, Tianyu Dong, Lingling Wang, Quanquan Guan, Ling Song, Daozhen Chen, Zuomin Zhou, Minjian Chen, Yankai Xia, Xinru Wang
Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We firstly analyzed the interaction on semen volume, sperm count per ejaculate, sperm concentration and sperm motility in 357 men, and found that urinary BPA concentration was significantly correlated with sperm count per ejaculate in obese men (β=-34...
August 2017: Environment International
https://www.readbyqxmd.com/read/28403270/evidence-for-anti-aging-south-korean-cosmeceuticals
#5
Ellinor R Quay, Yunyoung C Chang, Emmy Graber
<p>As the market for South Korean skin care products grows in the U.S. and worldwide, consumers will increasingly seek advice from dermatologists regarding their efficacy. In this paper, the evidence behind the anti-aging and skin whitening activity of ingredients in the most popular South Korean skin care products was reviewed and critically evaluated. Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea. The top selling products and their ingredients were then identified from individual brand websites...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28182848/simultaneous-determination-of-eight-b-vitamins-in-rat-intestinal-perfusate-to-identify-effects-of-osmotic-pressures-on-absorptions
#6
Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun
A rapid and accurate HPLC-DAD method was developed and validated to simultaneously determine eight B-vitamins (VBs, namely thiamine, riboflavin, niacinamide, calcium pantothenic, pyridoxine, biotin, folic acid and cyanocobalamin) and phenolsulfonphthalein in rat intestinal perfusate. Chromatographic separation was achieved using an Inertsil ODS-3 column (250 × 4.6 mm i.d., 5 μm) at a temperature of 40°C. Gradient elution mode was applied at the flow rate of 1.0 mL/min with the mobile phase of acetonitrile-30 mm K2 HPO4 (pH 5...
February 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28165180/faster-acting-insulin-aspart-provides-faster-onset-and-greater-early-exposure-vs-insulin-aspart-in-children-and-adolescents-with-type-1-diabetes-mellitus
#7
Maryam Fath, Thomas Danne, Torben Biester, Lars Erichsen, Olga Kordonouri, Hanne Haahr
BACKGROUND: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM: This randomized, double-blind, 2-period crossover trial investigated the pharmacological properties of faster aspart vs IAsp in 12 children (6-11 years), 13 adolescents (12-17 years), and 15 adults (18-64 years) with type 1 diabetes mellitus...
February 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28153652/in-vitro-permeation-and-disposition-of-niacinamide-in-silicone-and-porcine-skin-of-skin-barrier-mimetic-formulations
#8
Tasnuva Haque, Majella E Lane, Bruno C Sil, Jonathan M Crowther, David J Moore
Niacinamide (NIA) is an amide form of vitamin B3 which is used in cosmetic formulations to improve various skin conditions and it has also been shown to increase stratum corneum thickness following repeated application. In this study, three doses (5, 20 and 50μL per cm(2)) of two NIA containing oil-in-water skin barrier-mimetic formulations were evaluated in silicone membrane and porcine ear skin and compared with a commercial control formulation. Permeation studies were conducted over 24h in Franz cells and at the end of the experiment membranes were washed and niacinamide was extracted...
March 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28152570/niacin-intake-and-risk-of-skin-cancer-in-us-women-and-men
#9
Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Martin Weinstock, Abrar A Qureshi, Eunyoung Cho
A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospectively evaluated whether total, dietary and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010)...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28094872/niacinamide-leave-on-formulation-provide-long-lasting-protection-against-bacteria-in-vivo
#10
Mruthyunjaya M S, Prathyusha Mallemalla, Shilpa Vora, Vidula Iyer, Jyoti Kumar Tiwari, Amit Chakrabortty, Amitabha Majumdar
No abstract text is available yet for this article.
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28063095/the-use-of-cosmeceuticals-in-acne-help-or-hoax
#11
REVIEW
Brittany S Barros, Andrea L Zaenglein
The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid...
April 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28052374/use-of-nicotinamide-in-dermatology
#12
REVIEW
E Forbat, F Al-Niaimi, F R Ali
Nicotinamide (niacinamide) is the water-soluble, amide form of vitamin B3. We review the evidence underlying the use of nicotinamide for various dermatological indications, including nonmelanoma cancer prophylaxis, blistering disorders, acne vulgaris and cosmetic indications, and speculate upon its future role in dermatological practice.
March 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27986589/3-acetylpyridine-neurotoxicity-in-mice
#13
L Wecker, B Marrero-Rosado, M E Engberg, B E Johns, R M Philpot
3-acetylpyridine (3-AP) is a metabolic antagonist used in research to decrease levels of nicotinamide (niacinamide) in laboratory animals. The administration of 3-AP followed by nicotinamide to rats leads to the selective destruction of neurons in the medial inferior olive, resulting in a loss of climbing fibers innervating cerebellar Purkinje cells and a consequent ataxia manifest by alterations in both balance and gait. Although 3-AP has also been administered to mice to destroy neurons in the inferior olive, there are limited studies quantifying the consequent effects on balance, and no studies on gait...
January 2017: Neurotoxicology
https://www.readbyqxmd.com/read/27916694/regenerated-cellulose-capsules-for-controlled-drug-delivery-part-iv-in-vitro-evaluation-of-novel-self-pore-forming-regenerated-cellulose-capsules
#14
Bhavik Bhatt, Vijay Kumar
In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs...
January 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27846769/effect-of-cichorium-intybus-l-seed-extract-on-renal-parameters-in-experimentally-induced-early-and-late-diabetes-type-2-in-rats
#15
Yasin Pourfarjam, Lotfollah Rezagholizadeh, Azin Nowrouzi, Alipasha Meysamie, Sarah Ghaseminejad, Nasrin Ziamajidi, Davood Norouzi
Blood and urine biochemistry screening tests are important for initial detection of diabetes, determination of severity of its complications, and monitoring of therapy. We evaluated the effects of aqueous chicory seed extract (CSE), on renal biochemical parameters, histology, and Na+/glucose cotansporters, SGLT1 and SGLT2 expression levels using metformin, and aspirin as controls. Late stage type 2 diabetes (LT2D; FBS, >300 mg/dl) and early stage type 2 diabetes (ET2D; FBS, 140-220 mg/dl) were induced in rats by streptozotocin (STZ group) and a combination of STZ and niacinamide (NIA/STZ group), respectively...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/27759577/a-case-report-of-bullous-pemphigoid-associated-with-a-melanoma-and-review-of-the-literature
#16
Kyle T Amber, Christine M Panganiban, Dorota Korta, Sebastien de Feraudy, Kristen M Kelly, Sergei A Grando
The association of bullous pemphigoid with melanoma remains controversial and poorly understood. Recent studies report the presence of the bullous pemphigoid antigen, BP180, in melanoma cells, yet not normal melanocytes, suggesting an underlying mechanism for cases of melanoma-associated bullous pemphigoid. We report on an 88-year-old woman who showed a temporal relationship between the development of bullous pemphigoid and melanoma. The patient did not receive programmed death ligand 1 inhibitor therapy and improved rapidly following complete excision of her melanoma, with clobetasol, doxycycline, and niacinamide...
February 2017: Melanoma Research
https://www.readbyqxmd.com/read/27747960/clinical-and-microscopic-features-of-generalized-discoid-lupus-erythematosus-in-dogs-10-cases
#17
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27619974/spectroscopic-structural-characterizations-and-antioxidant-capacity-of-the-chromium-iii-niacinamide-compound-as-a-diabetes-mellitus-drug-model
#18
Moamen S Refat, Samy M El-Megharbel, M A Hussien, Reham Z Hamza, Mohamed A Al-Omar, Ahmed M Naglah, Walid M Afifi, Mohamed I Kobeasy
New binuclear chromium (III) niacinamide compound with chemical formula [Cr2(Nic)(Cl)6(H2O)4]·H2O was obtained upon the reaction of chromium (III) chloride with niacinamide (Nic) in methanol solvent at 60°C. The proposed structure was discussed with the help of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-vis.), magnetic calculations, thermogravimetric analyses (TG/TGA), and morphological studies (X-ray of solid powder and scan electron microscopy. The infrared spectrum of free niacinamide in comparison with its chromium (III) compound indicated that the chelation mode occurs via both nitrogen atoms of pyridine ring and primary -NH2 group...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27503774/-1-h-nmr-linked-metabolomics-analysis-of-liver-from-a-mouse-model-of-np-c1-disease
#19
Victor Ruiz-Rodado, Elena-Raluca Nicoli, Fay Probert, David A Smith, Lauren Morris, Christopher A Wassif, Frances M Platt, Martin Grootveld
Clinical manifestations of Niemann-Pick type C1 (NP-C1) disease include neonatal hepatosplenomegaly and in some patients progressive liver dysfunction and failure. This study involved a (1)H NMR-linked metabolomics analysis of liver samples collected from a NP-C1 disease mutant mouse model in order to explore time-dependent imbalances in metabolic pathways associated with NP-C1 liver dysfunction, including fibrosis. NP-C1 mutant (Npc1(-/-); NP-C1), control (Npc1(+/+); WT), and NP-C1 heterozygous mice (Npc1(+/-); HET) were generated from heterozygote matings...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27489862/durable-response-of-glioblastoma-to-adjuvant-therapy-consisting-of-temozolomide-and-a-weekly-dose-of-amd3100-plerixafor-a-cxcr4-inhibitor-together-with-lapatinib-metformin-and-niacinamide
#20
Adan Rios, Sigmund H Hsu, Angel Blanco, Jamie Buryanek, Arthur L Day, Mary F McGuire, Robert E Brown
UNLABELLED: Glioblastoma multiforme (GBM) is a CNS (central nervous system) malignancy with a low cure rate. Median time to progression after standard treatment is 7 months and median overall survival is 15 months [1]. Post-treatment vasculogenesis promoted by recruitment of bone marrow derived cells (BMDCs, CD11b+ myelomonocytes) is one of main mechanisms of GBM resistance to initial chemoradiotherapy treatment [2]. Local secretion of SDF-1, cognate ligand of BMDCs CXCR4 receptors attracts BMDCs to the post-radiation tumor site...
2016: Oncoscience
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