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https://www.readbyqxmd.com/read/28817114/trauma-informed-care-in-the-newborn-intensive-care-unit-promoting-safety-security-and-connectedness
#1
M R Sanders, S L Hall
Both babies and their parents may experience a stay in the newborn intensive care unit (NICU) as a traumatic or a 'toxic stress,' which can lead to dysregulation of the hypothalamic-pituitary-adrenal axis and ultimately to poorly controlled cortisol secretion. Toxic stresses in childhood or adverse childhood experiences (ACEs) are strongly linked to poor health outcomes across the lifespan and trauma-informed care is an approach to caregiving based on the recognition of this relationship. Practitioners of trauma-informed care seek to understand clients' or patients' behaviors in light of previous traumas they have experienced, including ACEs...
August 17, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28813201/applying-movement-ecology-to-marine-animals-with-complex-life-cycles
#2
Richard M Allen, Anna Metaxas, Paul V R Snelgrove
Marine animals with complex life cycles may move passively or actively for fertilization, dispersal, predator avoidance, resource acquisition, and migration, and over scales from micrometers to thousands of kilometers. This diversity has catalyzed idiosyncratic and unfocused research, creating unsound paradigms regarding the role of movement in ecology and evolution. The emerging movement ecology paradigm offers a framework to consolidate movement research independent of taxon, life-history stage, scale, or discipline...
August 16, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28812573/adjusting-diet-outcome-associations-for-random-error-comparison-of-associations-based-on-observed-and-estimated-usual-intakes
#3
E Verly-Jr, R Sichieri, V T Baltar
BACKGROUND/OBJECTIVES: To compare linear regression coefficients adjusted for random errors with true coefficients. SUBJECTS/METHODS: Three hundred and two individuals from the city of Rio de Janeiro, Brazil answered 20 non-consecutive 24-hr. Means of 20 24-hr were used as an approximation of the usual dietary intakes. It was simulated outcomes with pre-defined linear regression coefficient (β=1.0, referred as 'true coefficient') for usual coffee and soft-drink intakes as explanatory variables controlled for sex and age...
August 16, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28806728/costing-evidence-for-health-care-decision-making-in-austria-a-systematic-review
#4
Susanne Mayer, Noemi Kiss, Agata Łaszewska, Judit Simon
BACKGROUND: With rising healthcare costs comes an increasing demand for evidence-informed resource allocation using economic evaluations worldwide. Furthermore, standardization of costing and reporting methods both at international and national levels are imperative to make economic evaluations a valid tool for decision-making. The aim of this review is to assess the availability and consistency of costing evidence that could be used for decision-making in Austria. It describes systematically the current economic evaluation and costing studies landscape focusing on the applied costing methods and their reporting standards...
2017: PloS One
https://www.readbyqxmd.com/read/28805717/the-fragility-index-in-a-cohort-of-pediatric-randomized-controlled-trials
#5
Travis J Matics, Nadia Khan, Priti Jani, Jason M Kane
Data suggest inadequacy of common statistical techniques for reporting outcomes in clinical trials. The Fragility Index can measure how many events the statistical significance hinges on, and may facilitate better interpretation of trial results. This study aimed to assess the Fragility Index in pediatric randomized controlled trials (RCTs) with statistically significant findings published in high-quality medical journals. A Fragility Index was calculated on included trials with dichotomous positive outcomes...
August 14, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28803434/special-issue-of-biophysical-reviews-dedicated-to-the-19-th-iupab-conference-in-edinburgh-scotland-july-2017-%C3%AF
#6
EDITORIAL
Damien Hall, Cristobal G Dos Remedios
From the 16th to the 20th of July 2017, the 19th IUPAB (International Union of Pure and Applied Biophysics) world congress was held in Edinburgh, Scotland. Organized in conjunction with the 11th EBSA (European Biophysical Societies' Association) the meeting attracted over 1430 participants, had 35 scientific sessions and 10 plenary speakers. Each invited speaker was invited to contribute either a short review or a letter article that summarized the contents of their session. This special issue of Biophysical Reviews is dedicated to providing contextual background to some of the many talks presented at the meeting in Edinburgh...
August 12, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28800406/a-research-based-mantra-for-compassionate-caring
#7
Louise Terry, Roger Newham, Sinéad Hahessy, Siobhan Atherley, Yolanda Babenko-Mould, Marilyn Evans, Karen Ferguson, Graham Carr, S H Cedar
BACKGROUND: The United Kingdom introduced the Six C's strategy to help address deficits in approaching nursing care in a compassionate and caring manner. OBJECTIVE: To identify the book, article, poem, film or play that most influenced nurse educators' understanding of care and compassion and to articulate a clearer understanding of compassionate caring. DESIGN: A qualitative study applying discourse analysis to respondents' questionnaires and their nominated narrative...
August 2, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28800135/network-analysis-of-gut-microbiota-literature-an-overview-of-the-research-landscape-in-non-human-animal-studies
#8
Emily L Pascoe, Heidi C Hauffe, Julian R Marchesi, Sarah E Perkins
A wealth of human studies have demonstrated the importance of gut microbiota to health. Research on non-human animal gut microbiota is now increasing, but what insight does it provide? We reviewed 650 publications from this burgeoning field (2009-2016) and determined that animals driving this research were predominantly 'domestic' (48.2%), followed by 'model' (37.5%), with least studies on 'wild' (14.3%) animals. Domestic studies largely experimentally perturbed microbiota (81.8%) and studied mammals (47.9%), often to improve animal productivity...
August 11, 2017: ISME Journal
https://www.readbyqxmd.com/read/28797031/regulation-of-hypoxia-induced-autophagy-in-glioblastoma-involves-atg9a
#9
Siti Aminah Abdul Rahim, Anne Dirkse, Anais Oudin, Anne Schuster, Jill Bohler, Vanessa Barthelemy, Arnaud Muller, Laurent Vallar, Bassam Janji, Anna Golebiewska, Simone P Niclou
BACKGROUND: Hypoxia is negatively associated with glioblastoma (GBM) patient survival and contributes to tumour resistance. Anti-angiogenic therapy in GBM further increases hypoxia and activates survival pathways. The aim of this study was to determine the role of hypoxia-induced autophagy in GBM. METHODS: Pharmacological inhibition of autophagy was applied in combination with bevacizumab in GBM patient-derived xenografts (PDXs). Sensitivity towards inhibitors was further tested in vitro under normoxia and hypoxia, followed by transcriptomic analysis...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28795823/correction-to-sun-and-chen-2017
#10
(no author information available yet)
Reports an error in "Is Political Behavior a Viable Coping Strategy to Perceived Organizational Politics? Unveiling the Underlying Resource Dynamics" by Shuhua Sun and Huaizhong Chen (Journal of Applied Psychology, Advanced Online Publication, May 22, 2017, np). Table 1 contained a formatting error. Correlation coefficient values in the last four cells of column 6 were misplaced with correlation coefficient values in the last four cells of column 7. All versions of this article have been corrected. (The following abstract of the original article appeared in record 2017-22542-001...
August 10, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28794841/reporting-and-methodologic-evaluation-of-meta-analyses-published-in-the-anesthesia-literature-according-to-amstar-and-prisma-checklists-a-preliminary-study
#11
Jae Hoon Oh, Woo Jong Shin, Suin Park, Jae Soon Chung
BACKGROUND: There have been few recent reports on the methodological quality of meta-analysis, despite the enormous number of studies using meta-analytic techniques in the field of anesthesia. The purpose of this study was to evaluate the quality of meta-analyses and systematic reviews according to the Assessment of Multiple Systematic Reviews (AMSTAR) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in the anesthesia literature. METHODS: A search was conducted to identify all meta-analyses ever been published in the British Journal of Anaesthesia (BJA), Anaesthesia, and Korean Journal of Anesthesiology (KJA) between Jan...
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28792002/in-vitro-human-skin-permeation-of-benzene-in-gasoline-effects-of-concentration-multiple-dosing-and-skin-preparation
#12
H Frederick Frasch, Ana M Barbero
In vitro human skin benzene permeation was measured from gasoline formulations with benzene concentrations ranging from 0.8 to 10 vol% and from neat benzene. Steady-state fluxes (JSS), permeability coefficients (kp) and lag times (tlag) were calculated from infinite dose exposures. Permeation of benzene from small gasoline doses administered over a two-day period was also studied. The thermodynamic activity of benzene in gasoline at 30 °C was determined and the solution is near-ideal over the range from 0...
August 9, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28792001/implicating-candidate-genes-at-gwas-signals-by-leveraging-topologically-associating-domains
#13
Gregory P Way, Daniel W Youngstrom, Kurt D Hankenson, Casey S Greene, Struan Fa Grant
Genome-wide association studies (GWAS) have contributed significantly to the understanding of complex disease genetics. However, GWAS only report association signals and do not necessarily identify culprit genes. As most signals occur in non-coding regions of the genome, it is often challenging to assign genomic variants to the underlying causal mechanism(s). Topologically associating domains (TADs) are primarily cell-type-independent genomic regions that define interactome boundaries and can aid in the designation of limits within which an association most likely impacts gene function...
August 9, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28791472/keloid-skin-flap-retention-and-resurfacing-in-facial-keloid-treatment
#14
Shu Liu, Weizhong Liang, Kexin Song, Youbin Wang
OBJECTIVE: Facial keloids commonly occur in young patients. Multiple keloid masses often converge into a large lesion on the face, representing a significant obstacle to keloid mass excision and reconstruction. We describe a new surgical method that excises the keloid mass and resurfaces the wound by saving the keloid skin as a skin flap during facial keloid treatment. METHODS: Forty-five patients with facial keloids were treated in our department between January 2013 and January 2016...
August 8, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28782460/horticulture-in-portugal-1850-1900-the-role-of-science-and-public-utility-in-shaping-knowledge
#15
Ana Duarte Rodrigues, Ana Simões
In this paper, we address the emergence of horticultural practice, agents, spaces and institutions in the two urban settings of Lisbon and Porto, in Portugal, during the second half of the nineteenth century. We do so by following the networking activities of two players: the self-made horticulturist and entrepreneur José Marques Loureiro, who created, in Porto, a commercial horticultural establishment and founded the Journal of Practical Horticulture; and the agronomist Francisco Simões Margiochi, head of the gardens and green grounds department of the municipality, who created the first course on gardening and horticulture, and founded the Royal Horticultural Society, both in Lisbon...
August 7, 2017: Annals of Science
https://www.readbyqxmd.com/read/28782337/diagnosis-management-and-prevention-of-hepatitis-c-in-pakistan-2017
#16
Muhammad Umar, Hamama-Tul-Bushra Khaar, Tayyab Saeed Akhter, Faiza Aslam, Syed Irfan Ahmad, Rai Mohammad Asghar, Mohammad Khurram, Tassawar Hussain, Amjad Salamat, Anwar A Khan, Fazal-E-Hadi, Zahid Mahmood Minhas, Hasnain Ali Shah, Javed Farooqui, Asif Abbas Naqvi, Aftab Mohsin, Waseem-Ud-Din, Sohail Iqbal Bhutta, Sibt Ul Hasnain Syed, Saleem Qureshi, Tashfeen Adam, Moazzam Uddin, Ghias-U-Nabi Tayyab, Najeeb Ul Haq, Atifa Shoaib, Saima Ambreen, Arslan Shahzad, Nadeem Ikram, Gul Nisar, Mohammad Mujeeb Khan, Mohammad Osama
Aims and Objectives: Since the advent of direct acting antiviral agents, there is a revolutionary change in the management of HCV infection. Newer drugs with different mechanism of action are being introduced and are expected to be available in coming few months in Pakistan as well. The main purpose of the guideline is to review and induct the latest research in field of HCV infection in Pakistani perspective so that our healthcare professionals can apply the new recommendations in timely and judicial manner...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28777928/the-paired-t-test-and-beyond-recommendations-for-testing-the-central-tendencies-of-two-paired-samples-in-research-on-speech-language-and-hearing-pathology
#17
Toni Rietveld, Roeland van Hout
PURPOSE: In this tutorial we review current practice in the analysis of data obtained in designs involving two dependent samples and evaluate two conventional statistics: the t test for paired samples and its non-parametric alternative, the Wilcoxon Signed Ranks test (WSR). It is a sequel to our tutorial on the analysis of designs with two independent samples on the basis of non-count data (Rietveld & van Hout, 2015). The frequency with which these statistics are used is assessed on the basis of publications on disordered communication in Clinical Linguistics & Phonetics, Journal of Communication Disorders and Journal of Speech, Language and Hearing Research for the time interval 2006-2015...
July 25, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28777252/n-methyl-d-aspartate-receptor-nmdar-driven-calcium-influx-potentiates-the-adverse-effects-of-myocardial-ischemia-reperfusion-injury-ex-vivo
#18
Zi-You Liu, Shou Hu, Qin-Wen Zhong, Cheng-Nan Tian, Hou-Mou Ma, Jun-Jian Yu
BACKGROUND: Despite the adverse effects of N-methyl-D-aspartate receptor (NMDAR) activity in cardiomyocytes, no study has yet examined the effects of NMDAR activity under ex vivo ischemic-reperfusion (I/R) conditions. Therefore, our aim was to comprehensively evaluate the effects of NMDAR activity through an ex vivo myocardial I/R rat model. METHODS: Isolated rat hearts were randomly segregated into six groups (n=20 in each group): (i) an untreated control group; (ii) a NMDA-treated control group; (iii) an untreated I/R group; (iv) an I/R+NMDA group treated with NMDA; (v) an I/R+NMDA+MK-801 group treated with NMDA and the NMDAR inhibitor MK-801; and (vi) an I/R+NMDA+[Ca]-free group treated with NMDA and [Ca]-free buffer...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28775197/protocol-for-a-randomised-controlled-trial-of-90-kanuka-honey-versus-5-aciclovir-for-the-treatment-of-herpes-simplex-labialis-in-the-community-setting
#19
Alex Semprini, Joseph Singer, Nicholas Shortt, Irene Braithwaite, Richard Beasley
INTRODUCTION: Worldwide, about 90% of people are infected with the herpes simplex virus, 30% of whom will experience recurrent herpes simplex labialis, commonly referred to as 'cold sores', which can last up to 10 days. The most common treatment is aciclovir cream which reduces healing time by just half a day compared with no specific treatment. This is a protocol for a randomised controlled trial (RCT) to determine the efficacy of medical grade kanuka honey-based topical treatment (Honevo) in reducing the healing time and pain of cold sores, compared with topical aciclovir treatment (Viraban)...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28774374/effectiveness-and-cost-effectiveness-of-serum-b-type-natriuretic-peptide-testing-and-monitoring-in-patients-with-heart-failure-in-primary-and-secondary-care-an-evidence-synthesis-cohort-study-and-cost-effectiveness-model
#20
Maria Pufulete, Rachel Maishman, Lucy Dabner, Syed Mohiuddin, William Hollingworth, Chris A Rogers, Julian Higgins, Mark Dayer, John Macleod, Sarah Purdy, Theresa McDonagh, Angus Nightingale, Rachael Williams, Barnaby C Reeves
BACKGROUND: Heart failure (HF) affects around 500,000 people in the UK. HF medications are frequently underprescribed and B-type natriuretic peptide (BNP)-guided therapy may help to optimise treatment. OBJECTIVE: To evaluate the clinical effectiveness and cost-effectiveness of BNP-guided therapy compared with symptom-guided therapy in HF patients. DESIGN: Systematic review, cohort study and cost-effectiveness model. SETTING: A literature review and usual care in the NHS...
August 2017: Health Technology Assessment: HTA
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