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https://www.readbyqxmd.com/read/28430188/interactions-between-soil-and-dead-wood-inhabiting-fungal-communities-during-the-decay-of-norway-spruce-logs
#1
Raisa Mäkipää, Tiina Rajala, Dmitry Schigel, Katja T Rinne, Taina Pennanen, Nerea Abrego, Otso Ovaskainen
We investigated the interaction between fungal communities of soil and dead wood substrates. For this, we applied molecular species identification and stable isotope tracking to both soil and decaying wood in an unmanaged boreal Norway spruce-dominated stand. Altogether, we recorded 1990 operational taxonomic units, out of which more than 600 were shared by both substrates and 589 were found to exclusively inhabit wood. On average the soil was more species-rich than the decaying wood, but the species richness in dead wood increased monotonically along the decay gradient, reaching the same species richness and community composition as soil in the late stages...
April 21, 2017: ISME Journal
https://www.readbyqxmd.com/read/28427835/maxillofacial-growth-and-speech-outcome-after-one-stage-or-two-stage-palatoplasty-in-unilateral-cleft-lip-and-palate-a-systematic-review
#2
Rajgopal R Reddy, Srinivas Gosla Reddy, Anitha Vaidhyanathan, Stefaan J Bergé, Anne Marie Kuijpers-Jagtman
BACKGROUND: The number of surgical procedures to repair a cleft palate may play a role in the outcome for maxillofacial growth and speech. The aim of this systematic review was to investigate the relationship between the number of surgical procedures performed to repair the cleft palate and maxillofacial growth, speech and fistula formation in non-syndromic patients with unilateral cleft lip and palate. MATERIAL AND METHODS: An electronic search was performed in PubMed/old MEDLINE, the Cochrane Library, EMBASE, Scopus and CINAHL databases for publications between 1960 and December 2015...
March 22, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28426839/medical-history-in-the-hellenic-journal-of-nuclear-medicine
#3
EDITORIAL
Andreas Otte, Byeong Cheol Ahn
The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28426242/cellular-electron-cryotomography-toward-structural-biology-in-situ
#4
Catherine M Oikonomou, Grant J Jensen
Electron cryotomography (ECT) provides three-dimensional views of macromolecular complexes inside cells in a native frozen-hydrated state. Over the last two decades, ECT has revealed the ultrastructure of cells in unprecedented detail. It has also allowed us to visualize the structures of macromolecular machines in their native context inside intact cells. In many cases, such machines cannot be purified intact for in vitro study. In other cases, the function of a structure is lost outside the cell, so that the mechanism can be understood only by observation in situ...
April 19, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28424925/cross-vertical-mattress-suturing-with-basilar-tightening-during-the-correction-of-inverted-nipple-in-30-cases
#5
Weizhong Liang, Zuojun Zhao, Shu Liu, Tingmin Gu
OBJECTIVE: To investigate the efficacy of cross vertical mattress suturing with basilar tightening during the correction of inverted nipple. METHODS: Thirty patients with inverted nipples underwent cross vertical mattress suturing with basilar tightening. The postoperative results were recorded. RESULTS: All the patients were followed up for 6 months to 2 years. The results of 28 cases were satisfactory, and there was no recurrence. Two patients relapsed, and a mild depression was formed...
April 19, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28424481/the-first-genome-wide-association-study-identifying-new-susceptibility-loci-for-obstetric-antiphospholipid-syndrome
#6
Mayumi Sugiura-Ogasawara, Yosuke Omae, Minae Kawashima, Licht Toyo-Oka, Seik-Soon Khor, Hiromi Sawai, Tetsuya Horita, Tatsuya Atsumi, Atsuko Murashima, Daisuke Fujita, Tomio Fujita, Shinji Morimoto, Eriko Morishita, Shinji Katsuragi, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Katsushi Tokunaga
Antiphospholipid syndrome (APS) is the most important treatable cause of recurrent pregnancy loss. The live birth rate is limited to only 70-80% in patients with APS undergoing established anticoagulant therapy. Lupus anticoagulant (LA), but not anticardiolipin antibody (aCL), was found to predict adverse pregnancy outcome. Recent genome-wide association studies (GWAS) of APS focusing on aCL have shown that several molecules may be involved. This is the first GWAS for obstetric APS focusing on LA. A GWAS was performed to compare 115 Japanese patients with obstetric APS, diagnosed according to criteria of the International Congress on APS, and 419 healthy individuals...
April 20, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28418011/more-than-25-years-of-genetic-studies-of-clozapine-induced-agranulocytosis
#7
REVIEW
S A J de With, S L Pulit, W G Staal, R S Kahn, R A Ophoff
Clozapine is one of the most effective atypical antipsychotic drugs prescribed to patients with treatment-resistant schizophrenia. Approximately 1% of patients experience potential life-threatening adverse effects in the form of agranulocytosis, greatly hindering its applicability in clinical practice. The etiology of clozapine-induced agranulocytosis (CIA) remains unclear, but is thought to be a heritable trait. We reviewed the genetic studies of CIA published thus far. One recurrent finding from early candidate gene study to more recent genome-wide analysis is that of the involvement of human leukocyte antigen locus...
April 18, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28415862/multivariate-analysis-and-statistics-in-pharmaceutical-process-research-and-development
#8
José E Tabora, Nathan Domagalski
The application of statistics in pharmaceutical process research and development has evolved significantly over the past decades, motivated in part by the introduction of the Quality by Design paradigm, a landmark change in regulatory expectations for the level of scientific understanding associated with the manufacturing process. Today, statistical methods are increasingly applied to accelerate the characterization and optimization of new drugs created via numerous unit operations well known to the chemical engineering discipline...
April 17, 2017: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/28413630/patient-healthcare-trajectory-an-essential-monitoring-tool-a-systematic-review
#9
REVIEW
Jessica Pinaire, Jérôme Azé, Sandra Bringay, Paul Landais
BACKGROUND: Patient healthcare trajectory is a recent emergent topic in the literature, encompassing broad concepts. However, the rationale for studying patients' trajectories, and how this trajectory concept is defined remains a public health challenge. Our research was focused on patients' trajectories based on disease management and care, while also considering medico-economic aspects of the associated management. We illustrated this concept with an example: a myocardial infarction (MI) occurring in a patient's hospital trajectory of care...
December 2017: Health Information Science and Systems
https://www.readbyqxmd.com/read/28409206/inverted-nipple-correction-with-selective-dissection-of-lactiferous-ducts-using-an-operative-microscope-and-a-traction-technique
#10
Yoshihiro Sowa, Sizu Itsukage, Daiki Morita, Toshiaki Numajiri
BACKGROUND: An inverted nipple is a common congenital condition in young women that may cause breastfeeding difficulty, psychological distress, repeated inflammation, and loss of sensation. Various surgical techniques have been reported for correction of inverted nipples, and all have advantages and disadvantages. Here, we report a new technique for correction of an inverted nipple using an operative microscope and traction that results in low recurrence and preserves lactation function and sensation...
April 13, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28405067/heterogeneity-of-systematic-reviews-in-oncology
#11
REVIEW
Jonathan Holmes, David Herrmann, Chelsea Koller, Sarah Khan, Blake Umberham, Jody A Worley, Matt Vassar
Systematic reviews synthesize data across multiple studies to answer a research question, and an important component of the review process is to evaluate the heterogeneity of primary studies considered for inclusion. Little is known, however, about the ways that systematic reviewers evaluate heterogeneity, especially in clinical specialties like oncology. We examined a sample of systematic reviews from this body of literature to determine how meta-analysts assessed and reported heterogeneity. A PubMed search of 6 oncology journals was conducted to locate systematic reviews and meta-analyses...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28404609/moxibustion-versus-diclofenac-sodium-gel-for-the-treatment-of-knee-osteoarthritis-a-study-protocol-for-a-double-blinded-double-placebo-randomised-controlled-trial
#12
Jian-Ying Zhou, Ling Luo, Lin-Lin Zhu, Hai-Yan Yin, Qiaofeng Wu, Jia-Xi Peng, Cheng-Shun Zhang, Peng Lv, Yong Tang, Shu-Guang Yu
INTRODUCTION: Knee osteoarthritis is a common form of arthritis in elderly patients that is characterised by pain and functional limitation. Moxibustion has been employed to relieve chronic pain as an alternative therapy for knee osteoarthritis. However, the evidence of its efficacy is equivocal due to the low methodological quality in most clinical studies. Therefore, we are performing a double-blinded, double-placebo, randomised controlled trial to evaluate the efficacy of moxibustion in participants with knee osteoarthritis...
April 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28399014/physiotherapists-behaviour-attitudes-awareness-knowledge-and-barriers-in-relation-to-evidence-based-practice-implementation-in-saudi-arabia-a-cross-sectional-study
#13
Mansour A Alshehri, Ahmed Alalawi, Hammad Alhasan, Emma Stokes
AIM: The implementation of evidence-based practice (EBP) is extremely important and plays a vital role in healthcare practice. There have been few studies concerning the level of healthcare provided to patients in Saudi Arabia, using EBP as an indicator. This study is aimed at investigating physiotherapists' behaviour, attitudes, awareness and knowledge about EBP, along with barriers that curb the implementation of EBP. METHODS: A sample of convenience was used and an online survey consisting of 14 closed-ended questions was given to both clinical and academic physiotherapists in Saudi Arabia from May to October 2016...
April 10, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28393540/microfracture-state-of-the-art-in-cartilage-surgery
#14
Florian Frehner, Jan P Benthien
Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication quality has risen in orthopaedic sports medicine recently. Therefore, we think it is necessary to evaluate recent clinical trials being rated for their evidence-based medicine (EBM) quality. We also compared the mean impact factor of the journals publishing the different studies as an indicator of the study's citation and evaluated for a change over the studied time frame...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28389489/long-term-effect-of-smartphone-delivered-interval-walking-training-on-physical-activity-in-patients-with-type-2-diabetes-protocol-for-a-parallel-group-single-blinded-randomised-controlled-trial
#15
Laura Staun Valentiner, Mathias Ried-Larsen, Kristian Karstoft, Cecilie Fau Brinkløv, Charlotte Brøns, Rasmus Oestergaard Nielsen, Robin Christensen, Jens Steen Nielsen, Allan Arthur Vaag, Bente Klarlund Pedersen, Henning Langberg
INTRODUCTION: Physical activity is a cornerstone in type 2 diabetes (T2D) rehabilitation. Effective long-term and low-cost strategies to keep these patients' physically active are needed. However, maintaining physical activity behaviour is difficult once formalised interventions end. Structured exercise training supported by mobile technology and remote feedback is potentially an effective strategy. The objective of the trial is to investigate whether mobile health support using the InterWalk application for smartphones is effective in increasing physical activity levels in persons with T2D over time compared with standard care...
April 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28385690/what-is-the-impact-of-a-research-publication
#16
Seena Fazel, Achim Wolf
An increasing number of metrics are used to measure the impact of research papers. Despite being the most commonly used, the 2-year impact factor is limited by a lack of generalisability and comparability, in part due to substantial variation within and between fields. Similar limitations apply to metrics such as citations per paper. New approaches compare a paper's citation count to others in the research area, while others measure social and traditional media impact. However, none of these measures take into account an individual author's contribution to the paper or the number of authors, which we argue are key limitations...
April 6, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28383309/utility-of-functioning-in-predicting-costs-of-care-for-patients-with-mood-and-anxiety-disorders-a-prospective-cohort-study
#17
Conal Twomey, Alarcos Cieza, David S Baldwin
Development of payment systems for mental health services has been hindered by limited evidence for the utility of diagnosis or symptoms in predicting costs of care. We investigated the utility of functioning information in predicting costs for patients with mood and anxiety disorders. This was a prospective cohort study involving 102 adult patients attending a tertiary referral specialist clinic for mood and anxiety disorders. The main outcome was total costs, calculated by applying unit costs to healthcare use data...
April 5, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28382668/the-association-of-physical-activity-and-academic-behavior-a-systematic-review
#18
Rachel A Sullivan, AnnMarie H Kuzel, Michael E Vaandering, Weiyun Chen
BACKGROUND: In this systematic review, we assessed the existing research describing the effects of physical activity (PA) on academic behavior, with a special focus on the effectiveness of the treatments applied, study designs, outcome measures, and results. METHODS: We obtained data from various journal search engines and 218 journal articles were downloaded that were relevant to PA and academic performance topics. The abstracts of all the articles were independently peer reviewed to assess whether they met the inclusion criteria for further analysis...
May 2017: Journal of School Health
https://www.readbyqxmd.com/read/28381894/teaching-student-pharmacists-to-apply-drug-literature-to-patient-cases
#19
Robert D Beckett, Jennifer A Henriksen, Kierstan Hanson, Holly D Robison
Objective. To implement a series of activities designed to build drug literature evaluation skills and assess their impact on student pharmacists' ability to apply study results to patient cases. Design. Coursework was integrated across two didactic and pharmacy practice laboratory (PPL) courses. Team and individual journal clubs were used in traditional and case-based approaches during PPL courses to reinforce skills introduced in didactic courses. Student performance and perceptions were assessed during orientation for the third professional (P3) year and after the objective structured clinical examination (OSCE) at the end of the P3 year in identical drug literature evaluation assessments and pre- and post-intervention surveys of students...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28381242/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-15-24-edited-by-chinese-journal-of-cancer
#20
EDITORIAL
(no author information available yet)
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 10 more questions are presented as follows. Question 15: Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs? Question 16: Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor? Question 17: How can a cancer cell stay dormant for years? Question 18: Why do cancer cells use distinct transcriptomic and proteomic programs to reach the same metastatic phenotype? Question 19: Why do some cancers regress spontaneously? Question 20: What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells? Are the genetic transfer and exchange of biological messages between cells transient? Is the phenotypic manipulation of recipient cells temporary or prolonged and persistent? If extracellular vesicles possess immune-modulatory potential, how could they be exploited for immune interventions and cancer immunotherapy? Presumably the cargo of extracellular vesicles reflects the cells of their origin and can be used for cancer diagnosis, how could the uniform/stringent capture criteria be met universally for applying EVs in point-of-care diagnostics for cancer patients? Question 21: Can we use self-sampling technologies to monitor the tumor genetic alterations for more precise targeted therapy? Can we cure a heterogeneous tumor by sequentially targeting the driver molecules? Question 22: Can we postpone the onset of non-infection-related cancers? Question 23: How many types of cells can jointly form the tumor vasculature to provide blood supply for tumor progression? Question 24: How tumor cells transmit their epigenetic features to daughter cells and maintain the malignant phenotype?...
April 5, 2017: Chinese Journal of Cancer
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