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https://www.readbyqxmd.com/read/28338452/differentiation-of-idiopathic-spinal-cord-herniation-from-dorsal-arachnoid-webs-on-mri-and-ct-myelography
#1
Randall Schultz, Andrew Steven, Aaron Wessell, Nancy Fischbein, Charles A Sansur, Dheeraj Gandhi, David Ibrahimi, Prashant Raghavan
OBJECTIVE Dorsal arachnoid webs (DAWs) and spinal cord herniation (SCH) are uncommon abnormalities affecting the thoracic spinal cord that can result in syringomyelia and significant neurological morbidity if left untreated. Differentiating these 2 entities on the basis of clinical presentation and radiological findings remains challenging but is of vital importance in planning a surgical approach. The authors examined the differences between DAWs and idiopathic SCH on MRI and CT myelography to improve diagnostic confidence prior to surgery...
March 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28320317/navigo-interactive-tool-for-visualization-and-functional-similarity-and-coherence-analysis-with-gene-ontology
#2
Qing Wei, Ishita K Khan, Ziyun Ding, Satwica Yerneni, Daisuke Kihara
BACKGROUND: The number of genomics and proteomics experiments is growing rapidly, producing an ever-increasing amount of data that are awaiting functional interpretation. A number of function prediction algorithms were developed and improved to enable fast and automatic function annotation. With the well-defined structure and manual curation, Gene Ontology (GO) is the most frequently used vocabulary for representing gene functions. To understand relationship and similarity between GO annotations of genes, it is important to have a convenient pipeline that quantifies and visualizes the GO function analyses in a systematic fashion...
March 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28316236/webmolcs-a-web-based-interface-for-visualizing-molecules-in-3d-chemical-spaces
#3
Mahendra Awale, Daniel Probst, Jean-Louis Reymond
The concept of chemical space provides a convenient framework to analyze large collections of molecules by placing them in property spaces where distances represent similarities. Here we report webMolCS, a new type of web-based interface visualizing up to 5000 user-defined molecules in six different 3D chemical spaces obtained by principal component analysis or similarity mapping of multi-dimensional property spaces describing composition (MQN: 42D Molecular Quantum Numbers, SMIfp: 34D SMILES fingerprint), shapes and pharmacophores (APfp: 20D atom pair fingerprint, Xfp: 55D category extended atom pair fingerprint), and substructures (Sfp: 1024D binary substructure fingerprint, ECfp4: 1024D extended connectivity fingerprint)...
March 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28315472/complex-postaxial-polydactyly-types-a-and-b-with-camptodactyly-hypoplastic-third-toe-zygodactyly-and-other-digit-anomalies-caused-by-a-novel-gli3-mutation
#4
Sara Mumtaz, Esra Yildiz, Karmoon Lal, Aslıhan Tolun, Sajid Malik
Polydactyly is a phenotypically and genetically highly heterogeneous limb malformation with preaxial and postaxial subtypes and subtypes A and B. Most polydactyly entities are associated with GLI3 mutation. We report on 10 affected individuals from a large Pakistani kindred initially evaluated as a possible new condition. The phenotype is postaxial polydactyly types A and B associated with zygodactyly, postaxial webbing of toes and additional features not previously reported for isolated polydactyly such as camptodactyly, hypoplasia of third toe, and wide space between hallux and second toe...
March 14, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28300997/-the-contribution-of-web-2-0-technologies-to-the-empowerment-of-active-patients
#5
Martí Oliver-Mora, Lupicinio Iñiguez-Rueda
The Spanish health system has recently been marked by the emergence of more active patients who are characterized as being better informed about their disease, having a more participatory attitude, wanting to have a greater influence in making decisions about their health and asserting their rights as patients. Therefore, this article aims to report on how the introduction of Web 2.0 technologies can contribute to the empowering of more active patients. To achieve this, 14 semi-structured interviews were conducted with patients and representatives of patient associations who have used Web 2...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28292601/a-survey-of-cone-beam-computed-tomographic-use-among-endodontic-practitioners-in-the-united-states
#6
Frank C Setzer, Nathan Hinckley, Meetu R Kohli, Bekir Karabucak
INTRODUCTION: Cone-beam computed tomographic (CBCT) imaging is an emerging technology for clinical endodontic practice. The aim of this study was to investigate the acceptance, accessibility, and usage of CBCT imaging among American Association of Endodontists members in the United States by means of an online survey. METHODS: An invitation to participate in a web-based survey was sent to 3076 members of the American Association of Endodontists. The survey consisted of 8 questions on demographics, access to CBCT machines, field of view (FOV), frequency of use for particular applications, and reasons in case CBCT was not used...
March 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28287610/multivariate-simulation-framework-reveals-performance-of-multi-trait-gwas-methods
#7
Heather F Porter, Paul F O'Reilly
Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance is unclear. Here we develop a simulation framework to model the complex networks underlying multivariate genetic epidemiology, enabling the vast model space of genetic effects on multiple correlated traits to be explored systematically...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282284/increasing-the-use-of-earth-science-data-and-models-in-air-quality-management
#8
Jana B Milford, Daniel Knight
In 2010, the U.S. National Aeronautics and Space Administration (NASA) initiated the Air Quality Applied Science Team (AQAST) as a 5-year, $17.5-million award with 19 principal investigators. AQAST aims to increase the use of Earth science products in air quality-related research and to help meet air quality managers' information needs. We conducted a Web-based survey and a limited number of follow-up interviews to investigate federal, state, tribal, and local air quality managers' perspectives on usefulness of Earth science data and models, and on the impact AQAST has had...
April 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28279182/the-use-of-mesenchymal-stem-cells-for-cartilage-repair-and-regeneration-a-systematic-review
#9
REVIEW
Andy Goldberg, Katrina Mitchell, Julian Soans, Louise Kim, Razi Zaidi
BACKGROUND: The management of articular cartilage defects presents many clinical challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation techniques, such as microfracture, are the most frequently used method in clinical practice however the resulting mixed fibrocartilage tissue which is inferior to native hyaline cartilage. Other methods have shown promise but are far from perfect. There is an unmet need and growing interest in regenerative medicine and tissue engineering to improve the outcome for patients requiring cartilage repair...
March 9, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28272123/reconstruction-of-moderate-sized-hand-defects-using-a-superficial-lateral-sural-artery-perforator-flap
#10
Xiao-Qing He, Yue-Liang Zhu, Jia-Zhang Duan, Xi Yang, Fanzhe Feng, Yong-Qing Xu
BACKGROUND: The skin on the lower leg has abundant perforators and, thus, is an excellent donor site for transplant tissue flaps. However, due to vascular variations and body positions, tissue flaps at the posterolateral proximal portion of the lower leg are rarely used for transplantation. This study reports our experience with the use of superficial lateral sural artery perforator (SLSAP) flaps in the repair of moderate-sized hand wounds. METHODS: From March 2012 to April 2015, the hand wounds of 15 patients were planned for repair using a superficial sural artery perforator flap...
April 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28269272/a-pdms-based-optical-waveguide-for-transcutaneous-powering-of-microelectrode-arrays
#11
Ali Ersen, Mesut Sahin
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261433/ultrasonographic-and-clinical-characteristics-of-schwannoma-of-the-hand
#12
Seoung Joon Lee, Seok Tae Yoon
BACKGROUND: The purpose of this study was to report the ultrasonographic findings and clinical features of schwannoma of the hand. METHODS: We enrolled 8 patients who were initially diagnosed with ganglion by ultrasonography but finally with schwannoma by a tissue biopsy. We retrospectively analyzed the ultrasonographic findings of eight patients including echogenicity, internal homogeneity, posterior enhancement, internal vascularity, and clinical manifestations such as the occurrence site, tenderness, Tinel's sign, and paresthesia before the surgery...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28251874/prodigen-visualizing-the-probability-landscape-of-stochastic-gene-regulatory-networks-in-state-and-time-space
#13
Chihua Ma, Timothy Luciani, Anna Terebus, Jie Liang, G Elisabeta Marai
BACKGROUND: Visualizing the complex probability landscape of stochastic gene regulatory networks can further biologists' understanding of phenotypic behavior associated with specific genes. RESULTS: We present PRODIGEN (PRObability DIstribution of GEne Networks), a web-based visual analysis tool for the systematic exploration of probability distributions over simulation time and state space in such networks. PRODIGEN was designed in collaboration with bioinformaticians who research stochastic gene networks...
February 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28249977/the-role-of-the-width-of-the-forefoot-in-the-development-of-morton-s-neuroma
#14
Y H Park, S M Jeong, G W Choi, H J Kim
AIMS: Morton's neuroma is common condition of the forefoot, but its aetiology remains unclear. Our aim was to evaluate the relationship between the width of the forefoot and the development of a Morton's neuroma. PATIENTS AND METHODS: Between January 2013 and May 2016, a total of 84 consecutive patients (17 men, 67 women) with a unilateral Morton's neuroma were enrolled into the study. The involved and uninvolved feet of each patient were compared. A control group of patients with symptoms from the foot, but without a neuroma who were matched for age, gender, affected side, and web space location, were enrolled...
March 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28247920/adaptive-advantages-of-appearance-predation-thermoregulation-and-color-of-webbing-built-by-new-zealand-s-largest-moth
#15
Kirsty Yule, Kevin Burns
Prey are often difficult to locate visually, which may help them avoid predators. However, an animal's appearance might also evolve in response to the abiotic environment. Here, we investigate the processes that determine the appearance of silk webbing built by New Zealand's largest endemic moth Aenetus virescens (Lepidoptera: Hepialidae), whose larvae burrow into the trunks of native trees. Larvae cover tunnel entrances with silk webbing, detritus and epiphytes, giving them a similar appearance to tree bark...
March 1, 2017: Ecology
https://www.readbyqxmd.com/read/28244002/randomized-trial-of-a-social-networking-intervention-for-cancer-related-distress
#16
Jason E Owen, Erin O'Carroll Bantum, Ian S Pagano, Annette Stanton
BACKGROUND: Web and mobile technologies appear to hold promise for delivering evidence-informed and evidence-based intervention to cancer survivors and others living with trauma and other psychological concerns. Health-space.net was developed as a comprehensive online social networking and coping skills training program for cancer survivors living with distress. PURPOSE: The purpose of this study was to evaluate the effects of a 12-week social networking intervention on distress, depression, anxiety, vigor, and fatigue in cancer survivors reporting high levels of cancer-related distress...
February 27, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28227506/a-pdms-based-optical-waveguide-for-transcutaneous-powering-of-microelectrode-arrays
#17
Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28205252/sensory-deficits-after-a-radial-nerve-injury
#18
Jayme Augusto Bertelli, Erica Cavalli, Vera Lúcia Mendes Lehn, Marcos Flávio Ghizoni
BACKGROUND: The aim of our study was to objectively test sensibility on the dorsal side of the hand in patients with radial nerve injury, to document deficits and to detect if surgery for sensory reconstruction is needed. METHODS: Nineteen patients of mean age 31 ± 10 years were examined at a mean of 26.4 ± 27.8 months post radial nerve injury. Sensory mechanical thresholds on the dorsal surface of the hand were evaluated using Semmes-Weinstein monofilaments...
February 16, 2017: Microsurgery
https://www.readbyqxmd.com/read/28185593/decentralization-and-health-system-performance-a-focused-review-of-dimensions-difficulties-and-derivatives-in-india
#19
REVIEW
Bhuputra Panda, Harshad P Thakur
INTRODUCTION: One of the principal goals of any health care system is to improve health through the provision of clinical and public health services. Decentralization as a reform measure aims to improve inputs, management processes and health outcomes, and has political, administrative and financial connotations. It is argued that the robustness of a health system in achieving desirable outcomes is contingent upon the width and depth of 'decision space' at the local level. Studies have used different approaches to examine one or more facets of decentralization and its effect on health system functioning; however, lack of consensus on an acceptable framework is a critical gap in determining its quantum and quality...
October 31, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28179166/macroanatomy-and-3d-probabilistic-atlas-of-the-human-insula
#20
Isabelle Faillenot, Rolf A Heckemann, Maud Frot, Alexander Hammers
The human insula is implicated in numerous functions. More and more neuroimaging studies focus on this region, however no atlas offers a complete subdivision of the insula in a reference space. The aims of this study were to define a protocol to subdivide insula, to create probability maps in the MNI152 stereotaxic space, and to provide normative reference volume measurements for these subdivisions. Six regions were manually delineated bilaterally on 3D T1 MR images of 30 healthy subjects: the three short gyri, the anterior inferior cortex, and the two long gyri...
February 4, 2017: NeuroImage
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