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https://www.readbyqxmd.com/read/28205252/sensory-deficits-after-a-radial-nerve-injury
#1
Jayme Augusto Bertelli, Erica Cavalli, Vera Lúcia Mendes Lehn, Marcos Flávio Ghizoni
BACKGROUND: The aim of our study was to objectively test sensibility on the dorsal side of the hand in patients with radial nerve injury, to document deficits and to detect if surgery for sensory reconstruction is needed. METHODS: Nineteen patients of mean age 31 ± 10 years were examined at a mean of 26.4 ± 27.8 months post radial nerve injury. Sensory mechanical thresholds on the dorsal surface of the hand were evaluated using Semmes-Weinstein monofilaments...
February 16, 2017: Microsurgery
https://www.readbyqxmd.com/read/28185593/decentralization-and-health-system-performance-a-focused-review-of-dimensions-difficulties-and-derivatives-in-india
#2
REVIEW
Bhuputra Panda, Harshad P Thakur
INTRODUCTION: One of the principal goals of any health care system is to improve health through the provision of clinical and public health services. Decentralization as a reform measure aims to improve inputs, management processes and health outcomes, and has political, administrative and financial connotations. It is argued that the robustness of a health system in achieving desirable outcomes is contingent upon the width and depth of 'decision space' at the local level. Studies have used different approaches to examine one or more facets of decentralization and its effect on health system functioning; however, lack of consensus on an acceptable framework is a critical gap in determining its quantum and quality...
October 31, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28179166/macroanatomy-and-3d-probabilistic-atlas-of-the-human-insula
#3
Isabelle Faillenot, Rolf A Heckemann, Maud Frot, Alexander Hammers
The human insula is implicated in numerous functions. More and more neuroimaging studies focus on this region, however no atlas offers a complete subdivision of the insula in a reference space. The aims of this study were to define a protocol to subdivide insula, to create probability maps in the MNI152 stereotaxic space, and to provide normative reference volume measurements for these subdivisions. Six regions were manually delineated bilaterally on 3D T1 MR images of 30 healthy subjects: the three short gyri, the anterior inferior cortex, and the two long gyri...
February 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28176631/grid-based-continual-analysis-of-molecular-interior-for-drug-discovery-qsar-and-qspr
#4
A V Potemkin, M A Grishina, V A Potemkin
BACKGROUND: In 1979, R.D.Cramer and M.Milne made a first realization of the above mentioned principles attempting to compare molecules by aligning them in space and by mapping their molecular fields to a 3D grid. Further, this approach was developed as the DYLOMMS (DYnamic Lattice-Oriented Molecular Modelling System) approach. In 1984, H.Wold and S.Wold proposed the use of partial least squares (PLS) analysis, instead of principal component analysis, to correlate the field values with biological activities...
February 7, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28155662/an-ensemble-micro-neural-network-approach-for-elucidating-interactions-between-zinc-finger-proteins-and-their-target-dna
#5
Shayoni Dutta, Spandan Madan, Harsh Parikh, Durai Sundar
BACKGROUND: The ability to engineer zinc finger proteins binding to a DNA sequence of choice is essential for targeted genome editing to be possible. Experimental techniques and molecular docking have been successful in predicting protein-DNA interactions, however, they are highly time and resource intensive. Here, we present a novel algorithm designed for high throughput prediction of optimal zinc finger protein for 9 bp DNA sequences of choice. In accordance with the principles of information theory, a subset identified by using K-means clustering was used as a representative for the space of all possible 9 bp DNA sequences...
December 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28150237/navigating-the-glycome-space-and-connecting-the-glycoproteome
#6
Matthew P Campbell, Robyn A Peterson, Elisabeth Gasteiger, Julien Mariethoz, Frederique Lisacek, Nicolle H Packer
UniCarbKB ( http://unicarbkb.org ) is a comprehensive resource for mammalian glycoprotein and annotation data. In particular, the database provides information on the oligosaccharides characterized from a glycoprotein at either the global or site-specific level. This evidence is accumulated from a peer-reviewed and manually curated collection of information on oligosaccharides derived from membrane and secreted glycoproteins purified from biological fluids and/or tissues. This information is further supplemented with experimental method descriptions that summarize important sample preparation and analytical strategies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28149207/intraneural-median-nerve-anatomy-and-implications-for-treating-mixed-median-nerve-injury-in-the-hand
#7
Michael J Franco, Dennis C Nguyen, Benjamin Z Phillips, Susan E Mackinnon
Background: Nerve transfers have resulted in increased interest in the microanatomy of peripheral nerves. Herein, we expand our understanding of the internal anatomy of the digital nerve to the ulnar index and long fingers, the radial long and ring fingers, and the nerves to the second and third web spaces. Methods: The median nerve was dissected from the digital nerves to the antecubital fossa in 14 fresh upper extremities. The distance of proximal internal neurolysis of the fascicles to the second and third web space and proper digital nerves was measured relative to the radial styloid...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28149087/motor-cognitive-processing-speed-estimation-among-the-primary-schoolchildren-by-deriving-prediction-formula-a-cross-sectional-study
#8
Vencita Priyanka Aranha, Monika Moitra, Shikha Saxena, Kanimozhi Narkeesh, Narkeesh Arumugam, Asir John Samuel
OBJECTIVES: Motor cognitive processing speed (MCPS) is often reported in terms of reaction time. In spite of being a significant indicator of function, behavior, and performance, MCPS is rarely used in clinics and schools to identify kids with slowed motor cognitive processing. The reason behind this is the lack of availability of convenient formula to estimate MCPS. Thereby, the aim of this study is to estimate the MCPS in the primary schoolchildren. MATERIALS AND METHODS: Two hundred and four primary schoolchildren, aged 6-12 years, were recruited by the cluster sampling method for this cross-sectional study...
January 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28137270/malaria-control-and-prevention-towards-elimination-data-from-an-eleven-year-surveillance-in-shandong-province-china
#9
Xiangli Kong, Xin Liu, Hong Tu, Yan Xu, Jianbing Niu, Yongbin Wang, Changlei Zhao, Jingxuan Kou, Jun Feng
BACKGROUND: Shandong Province experienced a declining malaria trend of local-acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of malaria and the control and elimination strategy and interventions is needed for better planning to achieve the overall elimination goal in Shandong Province. METHODS: A retrospective study was conducted and all individual cases from a web-based reporting system were reviewed and analysed to explore malaria-endemic characteristics in Shandong from 2005 to 2015...
January 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28112863/importance-of-functional-groups-in-predicting-the-activity-of-small-molecule-inhibitors-for-bcl-2-and-bcl-xl
#10
Vishnupriya Kanakaveti, R Sakthivel, S K Rayala, M Michael Gromiha
Evasion of apoptosis owing to aberrant expression of Bcl-2 (B-cell lymphoma-2) anti-apoptotic proteins is a promising hallmark of cancer. These proteins are associated with resistance to chemotherapy and radiation. Currently available QSAR models are limited to a set of inhibitors corresponding to a particular chemical scaffold, and unified models are required to identify the differential specificity of diverse compounds towards inhibiting these targets. In this study, we predicted the factors driving differential activity and specificity implementing multiplexed QSAR analysis for a data set of 1649 reported inhibitors of Bcl-2 (B-cell lymphoma-2) and Bcl-xL (B-cell lymphoma-extra large)...
January 23, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28098680/insight-into-scabies
#11
Faye Mariz Razon, Emily Weidman-Evans
Scabies, an infectious disease caused by the scabies mite, manifests as an intensely pruritic skin rash. Children, the underprivileged, and patients with immunocompromise are at a higher risk of acquiring this contagious disease. Infectivity occurs worldwide in patients of all races, ages, and sex. The classical appearance of papular burrows between the webbed spaces of digits or along the wrists can help distinguish scabies from other dermatologic diseases. Practitioners need to be familiar with how scabies may present so that patients can be treated and taught how to prevent spread of the disease...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28095899/what-is-the-relationship-between-type-2-diabetes-mellitus-status-and-the-neuroradiological-correlates-of-cerebral-small-vessel-disease-in-adults-protocol-for-a-systematic-review
#12
Clark Funnell, Mary M Doyle-Waters, Samuel Yip, Thalia Field
BACKGROUND: Cerebral small vessel disease (CSVD) is a common cause of stroke, dementia, and functional decline. In recent years, neuroradiologic correlates of CSVD have been identified. These imaging findings, best characterized on magnetic resonance imaging (MRI), include some combination of white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Though some cohorts have reported that participants with type 2 diabetes mellitus (T2DM), an important risk factor for CSVD, may have a distinct neuroradiologic phenotype, this relationship is not well-characterized...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28093751/the-emergence-of-the-ecological-mind-in-hua-yen-kegon-buddhism-and-jungian-psychology
#13
Joe Cambray
The complexity associated with deep interconnectedness in nature is beginning to be articulated and elaborated in the field of ecological studies. While some parallels to the psyche have been made and the field of Eco-psychology has been developing, Jung's explicit contribution by way of the image of rhizomes has not been considered in detail. Philosopher Gilles Deleuze acknowledges borrowing the term from Jung, though he disagreed with Jung's Empedoclean use of the term. The paper presents some fundamental properties of rhizomes along with contemporary scientific research on mycorrhizal (fungal) networks...
February 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28067221/quantum-chemical-insights-from-deep-tensor-neural-networks
#14
Kristof T Schütt, Farhad Arbabzadah, Stefan Chmiela, Klaus R Müller, Alexandre Tkatchenko
Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text and image search, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding quantum many-body systems? Here we develop an efficient deep learning approach that enables spatially and chemically resolved insights into quantum-mechanical observables of molecular systems. We unify concepts from many-body Hamiltonians with purpose-designed deep tensor neural networks, which leads to size-extensive and uniformly accurate (1 kcal mol(-1)) predictions in compositional and configurational chemical space for molecules of intermediate size...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28050658/development-of-a-searchable-database-of-cryoablation-simulations-for-use-in-treatment-planning
#15
F Edward Boas, Govindarajan Srimathveeravalli, Jeremy C Durack, Elena A Kaye, Joseph P Erinjeri, Etay Ziv, Majid Maybody, Hooman Yarmohammadi, Stephen B Solomon
PURPOSE: To create and validate a planning tool for multiple-probe cryoablation, using simulations of ice ball size and shape for various ablation probe configurations, ablation times, and types of tissue ablated. MATERIALS AND METHODS: Ice ball size and shape was simulated using the Pennes bioheat equation. Five thousand six hundred and seventy different cryoablation procedures were simulated, using 1-6 cryoablation probes and 1-2 cm spacing between probes. The resulting ice ball was measured along three perpendicular axes and recorded in a database...
January 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28050432/epidermoid-cyst-of-the-sole-a-case-report
#16
Sathyakrishna Basavapatna Ramakrishnaiah, Santosh Singh Rajput, Nayar Sajeeth Gopinathan
Epidermoid cysts are common benign subcutaneous lesion also termed as epidermal cysts. Epidermoid cyst are commonly seen in hairy regions of body like scalp, face and scrotum, can be single or multiple, but rarely can occur in glabrous skin of palm and sole. They are known to result from progressive cystic ectasia of the infundibular portion of hair follicle but the pathogenesis in palmo-plantar epidermoid cyst differs that is traumatic sequestration of epidermal elements into dermis. Here, we report a case of 30-year-old female presented with complaints of swelling in her left sole...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048763/su-g-brc-10-feasibility-of-a-web-based-monte-carlo-simulation-tool-for-dynamic-electron-arc-radiotherapy-dear
#17
A Rodrigues, D Sawkey, Q Wu
PURPOSE: DEAR is a radiation therapy technique utilizing synchronized motion of gantry and couch during delivery to optimize dose distribution homogeneity and penumbra for treatment of superficial disease. Dose calculation for DEAR is not yet supported by commercial TPSs. The purpose of this study is to demonstrate the feasibility of using a web-based Monte Carlo (MC) simulation tool (VirtuaLinac) to calculate dose distributions for a DEAR delivery. METHODS: MC simulations were run through VirtuaLinac, which is based on the GEANT4 platform...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048082/su-f-i-62-a-dcm4chee-log-analyzer-for-monitoring-dicom-network-performance
#18
M Moriyama, Y Murakami, M Ohki, K Tokumori, S Okamoto
PURPOSE: The dcm4chee is an open source software for making a high-performance DICOM server. The process of dcm4chee is recorded in a log as text file. It takes a lot of time to read the log file for checking DICOM server performance. Therefore, we made a log analyzer for dcm4chee, which compiles the statistics on image transfer between DICOM server and imaging devices. METHODS: The log analysis program was written in Perl (practical extraction and report language)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046926/su-f-t-658-out-of-field-dose-comparison-for-truebeam-low-energy-beams-for-extended-distances-measurement-vs-monte-carlo-simulation
#19
K Wijesooriya, N Liyanage, M Kaluarachchi, D Sawkey
PURPOSE: Patient dose far from the treatment field is comprised of scatter from within the patient, and treatment head leakage. We quantify the treatment head leakage for TrueBeam linear accelerator for 6X and 6X-FFF beams by comparing measurements to Monte Carlo simulations for a variety of jaw sizes and collimator rotations. This work is conceptually similar to that of Kry et al. (Medical Physics 2006; 33: 4405), who considered a Clinac linear accelerator. METHODS: Measurements were made using an EXRADIN A101 ion chamber positioned in the patient plane, at distances up to 100 cm from isocenter...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039463/increased-risk-of-poor-survival-in-ovarian-cancer-patients-with-high-expression-of-snai2-and-lymphovascular-space-invasion
#20
Jun Li, Shufen Li, Ruifang Chen, Xin Lu
This study is aimed to conduct a meta-analysis to evaluate the prognostic value of lymphovascular space invasion(LVSI) and to explore the potential association of SNAI1 and SNAI2 with LVSI in ovarian cancer. A systematic literature search in PubMed, ISI Web of Science, and Medline was conducted to identify relevant studies assessing the prognostic value of LVSI in ovarian cancer. The main outcomes analyzed were progression free survival/disease free survival and overall survival. TCGA database was used to explore the potential link of SNAI1 and SNAI2 with LVSI status...
February 7, 2017: Oncotarget
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