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https://www.readbyqxmd.com/read/29351626/neuroendovascular-fellowship-training-self-assessment-of-a-program-accredited-by-the-committee-on-advanced-subspecialty-training
#1
Hakeem J Shakir, Hussain Shallwani, Leonardo Rangel-Castilla, Amade Bregy, Jason M Davies, Ashish Sonig, Christopher S Ogilvy, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy
The University at Buffalo's neuroendovascular fellowship is one of the longest running fellowship programs in North America. The burgeoning neurointerventional workforce and the rapid growth in the neurointerventional space on the heels of groundbreaking clinical trials prompted us to assess the fellowship's academic impact and its graduates' perceptions and productivity. An anonymized web-based survey was sent to all former neuroendovascular fellows with specific questions pertaining to current practice, research and funding, and perceptions about the fellowship's impact on their skills, competitiveness, and compensation...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29346410/an-evaluation-of-multi-probe-locality-sensitive-hashing-for-computing-similarities-over-web-scale-query-logs
#2
Graham Cormode, Anirban Dasgupta, Amit Goyal, Chi Hoon Lee
Many modern applications of AI such as web search, mobile browsing, image processing, and natural language processing rely on finding similar items from a large database of complex objects. Due to the very large scale of data involved (e.g., users' queries from commercial search engines), computing such near or nearest neighbors is a non-trivial task, as the computational cost grows significantly with the number of items. To address this challenge, we adopt Locality Sensitive Hashing (a.k.a, LSH) methods and evaluate four variants in a distributed computing environment (specifically, Hadoop)...
2018: PloS One
https://www.readbyqxmd.com/read/29334896/global-analysis-of-prokaryotic-trna-derived-cyclodipeptide-biosynthesis
#3
Michael A Skinnider, Chad W Johnston, Nishanth J Merwin, Chris A Dejong, Nathan A Magarvey
BACKGROUND: Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological activities. However, no tools are available to link cyclodipeptide synthases identified within prokaryotic genome sequences to their chemical products. Consequently, it is unclear how many genetically encoded cyclodipeptides represent novel products, and which producing organisms should be targeted for discovery. RESULTS: We developed a pipeline for identification and classification of cyclodipeptide biosynthetic gene clusters and prediction of aminoacyl-tRNA substrates and complete chemical structures...
January 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29332979/standardized-maximim-d-optimal-designs-for-enzyme-kinetic-inhibition-models
#4
Ping-Yang Chen, Ray-Bing Chen, Heng-Chin Tung, Weng Kee Wong
Locally optimal designs for nonlinear models require a single set of nominal values for the unknown parameters. An alternative is the maximin approach that allows the user to specify a range of values for each parameter of interest. However, the maximin approach is difficult because we first have to determine the locally optimal design for each set of nominal values before maximin types of optimal designs can be found via a nested optimization process. We show that particle swarm optimization (PSO) techniques can solve such complex optimization problems effectively...
October 15, 2017: Chemometrics and Intelligent Laboratory Systems
https://www.readbyqxmd.com/read/29328995/filter-base-a-web-accessible-chemical-database-for-small-compound-libraries
#5
Baban S Kolte, Sanjay R Londhe, Bhushan R Solanki, Rajesh N Gacche, Rohan J Meshram
Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup...
January 6, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29322209/infiltrating-angiolipoma-of-the-foot-magnetic-resonance-imaging-features-and-review-of-the-literature
#6
Eui Dong Yeo, Bo Mi Chung, Eun Ju Kim, Wan Tae Kim
Angiolipoma is a benign soft tissue tumor with two subtypes: non-infiltrating and infiltrating. Although histologically benign, infiltrating angiolipoma can invade surrounding structures. The foot is a very rare location for angiolipoma, with only four cases reported in the English literature, including one infiltrating type. Here, we report a very rare case of infiltrating angiolipoma of the foot with magnetic resonance imaging (MRI) and ultrasonography (US) findings. A 7-year-old boy presented with a slowly growing foot mass...
January 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29319351/amniotic-constriction-bands-secondary-deformities-and-their-treatments
#7
Benjamin T Drury, Ghazi M Rayan
BACKGROUND: The purpose of this study was to report the surgical treatment experience of patients with amniotic constriction bands (ACB) over a 35-year interval and detail consequential limb deformities with emphasis on hands and upper extremities, along with the nature and frequency of their surgical treatment methods. METHODS: Fifty-one patients were identified; 26 were males and 25 females. The total number of deformities was listed. The total number of operations, individual procedures, and operations plus procedures that were done for each patient and their frequency were recorded...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29318667/antibody-side-chain-conformations-are-position-dependent
#8
Jinwoo Leem, Guy Georges, Jiye Shi, Charlotte M Deane
Side chain prediction is an integral component of computational antibody design and structure prediction. Current antibody modelling tools use backbone-dependent rotamer libraries with conformations taken from general proteins. Here we present our antibody-specific rotamer library, where rotamers are binned according to their IMGT position, rather than their local backbone geometry. We find that for some amino acid types at certain positions, only a restricted number of side chain conformations are ever observed...
January 10, 2018: Proteins
https://www.readbyqxmd.com/read/29313380/an-on-top-plasty-reconstruction-for-complicated-radial-polydactyly
#9
Brian P Kelley, Carrie Kubiak, Kevin C Chung
BACKGROUND: The clinical presentation of radial polydactyly can vary greatly. Careful planning and appreciation of the anatomic subtleties provides alternative surgical options to improve patient outcomes. METHODS: We present a case of a well-formed accessory web space thumb and a hypoplastic primary thumb. RESULTS: Rather than excising the accessory digit, we performed a spare-part, on-top-plasty reconstruction to replace the diminutive distal phalanx of the primary thumb...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29307267/-there-is-zero-regulation-on-the-selling-of-alcohol-the-voice-of-the-youth-on-the-context-and-determinants-of-alcohol-drinking-in-lebanon
#10
Nasser Yassin, Rima Afifi, Neil Singh, Reem Saad, Lilian Ghandour
Alcohol-related research from the Arab world has rarely touched on the experiences or views of Arab adolescents. In this article, we present an in-depth analysis of youth alcohol drinking patterns and determinants derived from focus group discussions completed with more than 100 Lebanese high school/vocational students (15-19 years). The social ecology of alcohol use framework guided our research and analysis. Findings reveal that alcohol drinking is perceived as a pervasive and serious public health problem, triggered by a complex web of social relations, and facilitated by lax policies...
January 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29304432/the-largest-lyapunov-exponent-of-gait-in-young-and-elderly-individuals-a-systematic-review
#11
REVIEW
Sina Mehdizadeh
The largest Lyapunov exponent (LyE) is an accepted method to quantify gait stability in young and old adults. However, a range of LyE values has been reported in the literature for healthy young and elderly adults in normal walking. Therefore, it has been impractical to use the LyE as a clinical measure of gait stability. The aims of this systematic review were to summarize different methodological approaches of quantifying LyE, as well as to classify LyE values of different body segments and joints in young and elderly individuals during normal walking...
December 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29286959/congenital-quintus-valgus-an-extremely-rare-anomaly-a-case-report
#12
Ali J Electricwala, Jaffer T Electricwala
CASE: We present an unusual case of unilateral congenital quintus valgus of the left foot (congenital lateral deviation of the fifth [little] toe) in a 1.5-year-old boy. The child had no other congenital malformations. Radiographs revealed the abnormal presence of 2 accessory phalangeal ossicles in the fourth web space, leading to lateral deviation of the fifth toe. Remarkably, the ossicles of the middle and distal phalanges of the fifth toe were absent. Surgical excision of the accessory ossicles was performed, and correction of the deformity was achieved...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29286729/dirac-and-nodal-line-magnons-in-three-dimensional-antiferromagnets
#13
Kangkang Li, Chenyuan Li, Jiangping Hu, Yuan Li, Chen Fang
We study the topological properties of magnon excitations in three-dimensional antiferromagnets, where the ground state configuration is invariant under time reversal followed by space inversion (PT symmetry). We prove that Dirac points and nodal lines, the former being the limiting case of the latter, are the generic forms of symmetry-protected band crossings between magnon branches. As a concrete example, we study a Heisenberg spin model for a "spin-web" compound, Cu_{3}TeO_{6}, and show the presence of the magnon Dirac points assuming a collinear magnetic structure...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29286379/automated-robotic-liquid-handling-assembly-of-modular-dna-devices
#14
Luis Ortiz, Marilene Pavan, Lloyd McCarthy, Joshua Timmons, Douglas M Densmore
Recent advances in modular DNA assembly techniques have enabled synthetic biologists to test significantly more of the available "design space" represented by "devices" created as combinations of individual genetic components. However, manual assembly of such large numbers of devices is time-intensive, error-prone, and costly. The increasing sophistication and scale of synthetic biology research necessitates an efficient, reproducible way to accommodate large-scale, complex, and high throughput device construction...
December 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29283499/pharyngeal-airway-changes-following-maxillary-expansion-or-protraction-a-meta-analysis
#15
REVIEW
W-C Lee, Y-K Tu, C-S Huang, R Chen, M-W Fu, E Fu
The aim of this meta-analysis was to investigate the changes in airway dimensions after rapid maxillary expansion (RME) and facemask (FM) protraction. Using PubMed, Medline, ScienceDirect and Web of Science, only controlled clinical trials, published up to November 2016, with RME and/or FM as keywords that had ≥6 months follow-up period were included in this meta-analysis. The changes in pharyngeal airway dimension in both two-dimensional and three-dimensional images were included in the analysis. Nine studies met the criteria...
December 28, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/29276046/drug-target-commons-a-community-effort-to-build-a-consensus-knowledge-base-for-drug-target-interactions
#16
Jing Tang, Zia-Ur-Rehman Tanoli, Balaguru Ravikumar, Zaid Alam, Anni Rebane, Markus Vähä-Koskela, Gopal Peddinti, Arjan J van Adrichem, Janica Wakkinen, Alok Jaiswal, Ella Karjalainen, Prson Gautam, Liye He, Elina Parri, Suleiman Khan, Abhishekh Gupta, Mehreen Ali, Laxman Yetukuri, Anna-Lena Gustavsson, Brinton Seashore-Ludlow, Anne Hersey, Andrew R Leach, John P Overington, Gretchen Repasky, Krister Wennerberg, Tero Aittokallio
Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration...
December 15, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29273721/topographical-diversity-of-common-skin-microflora-and-its-association-with-skin-environment-type-an-observational-study-in-chinese-women
#17
Xi Li, Chao Yuan, Licong Xing, Philippe Humbert
This study evaluated cutaneous microbial distribution, and microbial co-occurrence at different body sites and skin environments in Chinese women (39.6 ± 11.9 years, N = 100) during the winter season. Microbial distribution (Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Lactobacillus, Pseudomonadaceae, and Malassezia furfur), association with biomarkers (antimicrobial peptides: LL-37, β-defensins [HBD-2, HBD-3]), and claudin-1) and skin biophysical parameters (transepidermal water loss, pH, skin scaliness and roughness, sebum and hydration levels) were also determined...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29236707/translating-statistical-species-habitat-models-to-interactive-decision-support-tools
#18
Lyndsie S Wszola, Victoria L Simonsen, Erica F Stuber, Caitlyn R Gillespie, Lindsey N Messinger, Karie L Decker, Jeffrey J Lusk, Christopher F Jorgensen, Andrew A Bishop, Joseph J Fontaine
Understanding species-habitat relationships is vital to successful conservation, but the tools used to communicate species-habitat relationships are often poorly suited to the information needs of conservation practitioners. Here we present a novel method for translating a statistical species-habitat model, a regression analysis relating ring-necked pheasant abundance to landcover, into an interactive online tool. The Pheasant Habitat Simulator combines the analytical power of the R programming environment with the user-friendly Shiny web interface to create an online platform in which wildlife professionals can explore the effects of variation in local landcover on relative pheasant habitat suitability within spatial scales relevant to individual wildlife managers...
2017: PloS One
https://www.readbyqxmd.com/read/29235101/aquatic-food-web-dynamics-following-incorporation-of-nutrients-derived-from-atlantic-anadromous-fishes
#19
K M Samways, D X Soto, R A Cunjak
Changes in the isotopic composition (δ13 C and δ15 N) in biofilm, macro-invertebrates and resident salmonids were used to characterize temporal dynamics of marine derived nutrients (MDNs) incorporation between stream reaches with and without MDN inputs. Five Atlantic rivers were chosen to represent contrasting MDN subsidies: four rivers with considerable numbers of anadromous fishes; one river with little MDN input. Rainbow smelt Osmerus mordax, alewife Alosa pseudoharengus, sea lamprey Petromyzon marinus and Atlantic salmon Salmo salar, were the primary anadromous species for the sampled rivers...
December 12, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29234984/bober-web-interface-to-the-base-of-bioisosterically-exchangeable-replacements
#20
Samo Lešnik, Blaž Škrlj, Nika Eržen, Urban Bren, Stanislav Gobec, Janez Konc, Dušanka Janežič
We describe a novel freely available web server Base of Bioisosterically Exchangeable Replacements (BoBER), which implements an interface to a database of bioisosteric and scaffold hopping replacements. Bioisosterism and scaffold hopping are key concepts in drug design and optimization, and can be defined as replacements of biologically active compound's fragments with other fragments to improve activity, reduce toxicity, change bioavailability or to diversify the scaffold space. Our web server enables fast and user-friendly searches for bioisosteric and scaffold replacements which were obtained by mining the whole Protein Data Bank...
December 12, 2017: Journal of Cheminformatics
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