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https://www.readbyqxmd.com/read/29132790/ulnar-thumb-pulp-reconstruction-using-the-anterograde-homodigital-neurovascular-island-flap
#1
REVIEW
Valeriy Shubinets, River M Elliott
The thumb ulnar pulp is a critical component of key pinch and precision manipulation. Injuries to this area should be reconstructed with robust, sensate tissue that restores bulk and contour. The existing reconstructive options, however, have substantial risks and drawbacks. We describe an anterograde homodigital neurovascular island flap that provides both sensate and durable coverage of the ulnar thumb pulp. The flap uses innervated glabrous tissue, limits donor site morbidity to the thumb and first web space, and does not require microvascular anastomoses or nerve coaptation...
November 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29132254/reverse-flow-intrinsic-fasciocutaneous-island-flaps-in-foot-reconstruction
#2
Sujin Bahk, GyeongHyeon Doh, Ki Yong Hong, SooA Lim, SuRak Eo
Reconstruction of soft tissue defects in the foot remains a challenge due to its specialized tissue for weightbearing and ambulation. Considering the principle of replacing "like with like," adjacent soft tissues would be a best option for a donor site. Although several kinds of reverse-flow island flaps for the lower leg have been well described, intrinsic foot reverse flow flaps have been rarely reported. We describe 3 kinds of reverse-flow intrinsic fasciocutaneous flaps (RIFFs) for foot reconstruction. From September 2012 to August 2015, a retrospective study was done on case notes of all patients who had a RIFF for coverage of soft tissue defects within the foot following trauma or tumor ablation...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29130235/-a-meta-analysis-on-risk-factors-of-postoperative-perineal-wound-complications-after-abdominoperineal-resection-for-rectal-cancer
#3
Senqi Lu, Xiaofeng Chang, Xiaodong Yang, Decai Yu, Qigen Huang, Feng Wang
OBJECTIVE: To investigate the risk factors of postoperative perineal wound complications after abdominoperineal resection for rectal cancer. METHODS: The databases of Medline, Embase, Web of Science, Ovid, Cochrane Library, CBM, CNKI, VIP and WANFANG were searched for the studies of abdominoperineal resection up to October 2016. The quality of the included studies was assessed by using "Cochrane collaboration's tool for assessing risk of bias" and "the Newcastle-Ottawa Scale"...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29111222/ssel-ade-a-semi-supervised-ensemble-learning-framework-for-extracting-adverse-drug-events-from-social-media
#4
Jing Liu, Songzheng Zhao, Gang Wang
With the development of Web 2.0 technology, social media websites have become lucrative but under-explored data sources for extracting adverse drug events (ADEs), which is a serious health problem. Besides ADE, other semantic relation types (e.g., drug indication and beneficial effect) could hold between the drug and adverse event mentions, making ADE relation extraction - distinguishing ADE relationship from other relation types - necessary. However, conducting ADE relation extraction in social media environment is not a trivial task because of the expertise-dependent, time-consuming and costly annotation process, and the feature space's high-dimensionality attributed to intrinsic characteristics of social media data...
October 27, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29101138/do-digital-innovations-for-hiv-and-sexually-transmitted-infections-work-results-from-a-systematic-review-1996-2017
#5
Jana Daher, Rohit Vijh, Blake Linthwaite, Sailly Dave, John Kim, Keertan Dheda, Trevor Peter, Nitika Pant Pai
OBJECTIVE: Digital innovations with internet/mobile phones offer a potential cost-saving solution for overburdened health systems with high service delivery costs to improve efficiency of HIV/STI (sexually transmitted infections) control initiatives. However, their overall evidence has not yet been appraised. We evaluated the feasibility and impact of all digital innovations for all HIV/STIs. DESIGN: Systematic review. SETTING/PARTICIPANTS: All settings/all participants...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29075027/mini-implants-for-orthodontic-anchorage
#6
Reint Meursinge Reynders, Luisa Ladu
Data sourcesPubmed, Embase, Cochrane Central Register of Controlled Trials and the Web of Science databases. Hand searches of the journals European Journal of Orthodontics, Journal of Orthodontics, Journal of Clinical Orthodontics, Seminars in Orthodontics, American Journal of Orthodontics & Dentofacial Orthopaedics and Angle Orthodontist.Study selectionTwo reviewers independently selected studies. Randomised controlled trials (RCTs) and controlled clinical trials (CCTs) of orthodontic patients requiring extraction of the maxillary first premolars and closure of the spaces without anchorage loss were considered...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29054615/where-is-the-usa-corn-belt-and-how-is-it-changing
#7
Timothy R Green, Holm Kipka, Olaf David, Gregory S McMaster
The "Corn Belt" is a commonly used term, but often referenced as a vaguely defined region in the Midwest USA. A few key studies have delineated synoptic maps of the Corn Belt boundaries going back to the early 20th century, but a modern flexible and accessible framework for mapping the Corn Belt in space and time is needed. New tools provide reference maps for the Corn Belt in the 21st century and the ability to quantify space-time changes in corn cropping patterns. The Landuse and Agricultural Management Practices web-Service (LAMPS) was used to estimate the average corn (maize, Zea mays L...
October 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29032233/proteome-wide-prediction-and-annotation-of-mitochondrial-and-sub-mitochondrial-proteins-by-incorporating-domain-information
#8
Ravindra Kumar, Bandana Kumari, Manish Kumar
Mitochondrion is one of the most important subcellular organelle of eukaryotic cells. It carries out several biochemical functions that are extremely vital for cells. Defects in mitochondria also play an important role in the development and progression of different types of cancer. Therefore knowledge of complete mitochondrial protein repertoire is essential to understand overall mitochondrial functionality, maintenance, dynamics and metabolism. It would be of a great practical significance to develop an automated and reliable approach that can identify the mitochondrial proteins and their sub-mitochondrial location...
October 11, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29026435/halign-ii-efficient-ultra-large-multiple-sequence-alignment-and-phylogenetic-tree-reconstruction-with-distributed-and-parallel-computing
#9
Shixiang Wan, Quan Zou
BACKGROUND: Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. METHODS: Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses...
2017: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/28987008/mvmapper-interactive-spatial-mapping-of-genetic-structures
#10
Julian R Dupuis, Forest T Bremer, Thibaut Jombart, Sheina B Sim, Scott M Geib
Characterizing genetic structure across geographic space is a fundamental challenge in population genetics. Multivariate statistical analyses are powerful tools for summarizing genetic variability, but geographic information and accompanying metadata are not always easily integrated into these methods in a user-friendly fashion. Here, we present a deployable Python-based web-tool, mvmapper, for visualizing and exploring results of multivariate analyses in geographic space. This tool can be used to map results of virtually any multivariate analysis of georeferenced data, and routines for exporting results from a number of standard methods have been integrated in the R package adegenet, including principal components analysis (PCA), spatial PCA, discriminant analysis of principal components, principal coordinates analysis, nonmetric dimensional scaling and correspondence analysis...
October 7, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28976996/beyond-funding-acknowledgement-patterns-in-biomedical-natural-and-social-sciences
#11
Adèle Paul-Hus, Adrián A Díaz-Faes, Maxime Sainte-Marie, Nadine Desrochers, Rodrigo Costas, Vincent Larivière
For the past 50 years, acknowledgments have been studied as important paratextual traces of research practices, collaboration, and infrastructure in science. Since 2008, funding acknowledgments have been indexed by Web of Science, supporting large-scale analyses of research funding. Applying advanced linguistic methods as well as Correspondence Analysis to more than one million acknowledgments from research articles and reviews published in 2015, this paper aims to go beyond funding disclosure and study the main types of contributions found in acknowledgments on a large scale and through disciplinary comparisons...
2017: PloS One
https://www.readbyqxmd.com/read/28975713/pepsweetener-a-web-based-tool-to-support-manual-annotation-of-intact-glycopeptide-ms-spectra
#12
Marcin Jakub Domagalski, Davide Alocci, Andreia Almeida, Daniel Kolarich, Frédérique Lisacek
PURPOSE: PepSweetener is a web-based visualization tool designed to facilitate the manual annotation of intact glycopeptides from mass spectrometry (MS) data regardless of the instrument that produced this data. EXPERIMENTAL DESIGN: This exploratory tool uses a theoretical glycopeptide dataset to visualize all peptide-glycan combinations that fall within the error range of the query precursor ion. PepSweetener simplifies the determination of the correct peptide and glycan composition of a glycopeptide based on its precursor mass...
October 3, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28968713/an-automated-tool-for-obtaining-qsar-ready-series-of-compounds-using-semantic-web-technologies
#13
Oriol López-Massaguer, Ferran Sanz, Manuel Pastor
Summary: We describe an application (Collector) for obtaining series of compounds annotated with bioactivity data, ready to be used for the development of quantitative structure-activity relationships (QSAR) models. The tool extracts data from the 'Open Pharmacological Space' (OPS) developed by the Open PHACTS project, using as input a valid name of the biological target. Collector uses the OPS ontologies for expanding the query using all known target synonyms and extracts compounds with bioactivity data against the target from multiple sources...
September 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28966897/new-dmsp-database-of-precipitating-auroral-electrons-and-ions
#14
Robert J Redmon, William F Denig, Liam M Kilcommons, Delores J Knipp
Since the mid 1970's, the Defense Meteorological Satellite Program (DMSP) spacecraft have operated instruments for monitoring the space environment from low earth orbit. As the program evolved, so to have the measurement capabilities such that modern DMSP spacecraft include a comprehensive suite of instruments providing estimates of precipitating electron and ion fluxes, cold/bulk plasma composition and moments, the geomagnetic field, and optical emissions in the far and extreme ultraviolet. We describe the creation of a new public database of precipitating electrons and ions from the Special Sensor J (SSJ) instrument, complete with original counts, calibrated differential fluxes adjusted for penetrating radiation, estimates of the total kinetic energy flux and characteristic energy, uncertainty estimates, and accurate ephemerides...
August 2017: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/28965988/influence-of-orthodontic-premolar-extraction-therapy-on-the-eruption-of-the-third-molars-a-systematic-review-of-the-literature
#15
REVIEW
Damien Brezulier, Victor Fau, Olivier Sorel
BACKGROUND: Through a systematic literature review, the authors assess the effect of premolar extractions on third-molar (M3) eruption considering eruption rate, retromolar space, and molar angulation. TYPES OF STUDIES REVIEWED: The authors performed a systematic search using MEDLINE and Web of Science databases up through April 2017 to identify quality studies available comparing M3 eruption between a group with premolar extraction and a group without premolar extraction...
September 28, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28961954/pimp-my-metabolome-an-integrated-web-based-tool-for-lc-ms-metabolomics-data
#16
Yoann Gloaguen, Fraser Morton, Rónán Daly, Ross Gurden, Simon Rogers, Joe Wandy, David Wilson, Michael Barrett, Karl Burgess
Summary: The Polyomics integrated Metabolomics Pipeline (PiMP) fulfils an unmet need in metabolomics data analysis. PiMP offers automated and user-friendly analysis from mass spectrometry data acquisition to biological interpretation. Our key innovations are the Summary Page, which provides a simple overview of the experiment in the format of a scientific paper, containing the key findings of the experiment along with associated metadata; and the Metabolite Page, which provides a list of each metabolite accompanied by 'evidence cards', which provide a variety of criteria behind metabolite annotation including peak shapes, intensities in different sample groups and database information...
August 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28961075/indocyanine-green-lymphographic-and-lymphoscintigraphic-findings-in-genital-lymphedema-genital-pathway-score
#17
Hisako Hara, Makoto Mihara
BACKGROUND: Although genital lymphedema is a challenging disease, its mechanism is unclear. The aim of this study was to identify the lymphatic flow in genital lymphedema and establish a suitable examination for genital lymphedema. METHODS: We injected phytic acid or albumin labeled with (99m)Tc at the bilateral first web spaces of the feet of 47 patients for lymphoscintigraphy. For indocyanine green (ICG) lymphography, we injected ICG into the first web spaces of both feet and other points if necessary...
September 29, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28954678/fate-of-environmental-pollutants
#18
Rahul Kumar, Lokesh P Padhye
This annual review covers the literature published in 2016 on topics related to the occurrence and fate of emerging environmental pollutants in wastewater. Due to the vast amount of literature published on this topic, we have discussed only a portion of the quality research publications, due to limitation of space. The abstract search was carried out using Web of Science, and the abstracts were selected based on their relevance. In few cases, fulltext articles were referred to better understand new findings...
October 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28951341/culture-characterization-of-the-skin-microbiome-in-type-2-diabetes-mellitus-a-focus-on-the-role-of-innate-immunity
#19
Akshay Thimmappaiah Jagadeesh, Peralam Yegneswaran Prakash, N Karthik Rao, V Ramya
AIMS: The current study aimed at determining the differences between the cutaneous microbial flora of patients with Type 2 diabetes mellitus (T2DM) and those without, and thus evaluate for cutaneous microbiome dysbiosis in diabetes. METHODS: We employed a case-control study design with 41 participants in each group. The skin over the toe-web space was swabbed and cultured aerobically. Data was analyzed for differences in microbial prevalences and growths between the two groups...
September 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28950866/public-and-patient-involvement-in-needs-assessment-and-social-innovation-a-people-centred-approach-to-care-and-research-for-congenital-disorders-of-glycosylation
#20
Cláudia de Freitas, Vanessa Dos Reis, Susana Silva, Paula A Videira, Eva Morava, Jaak Jaeken
BACKGROUND: Public and patient involvement in the design of people-centred care and research is vital for communities whose needs are underserved, as are people with rare diseases. Innovations devised collectively by patients, caregivers, professionals and other members of the public can foster transformative change toward more responsive services and research. However, attempts to involve lay and professional stakeholders in devising community-framed strategies to address the unmet needs of rare diseases are lacking...
September 26, 2017: BMC Health Services Research
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