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Faye Mariz Razon, Emily Weidman-Evans
Scabies, an infectious disease caused by the scabies mite, manifests as an intensely pruritic skin rash. Children, the underprivileged, and patients with immunocompromise are at a higher risk of acquiring this contagious disease. Infectivity occurs worldwide in patients of all races, ages, and sex. The classical appearance of papular burrows between the webbed spaces of digits or along the wrists can help distinguish scabies from other dermatologic diseases. Practitioners need to be familiar with how scabies may present so that patients can be treated and taught how to prevent spread of the disease...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
Clark Funnell, Mary M Doyle-Waters, Samuel Yip, Thalia Field
BACKGROUND: Cerebral small vessel disease (CSVD) is a common cause of stroke, dementia, and functional decline. In recent years, neuroradiologic correlates of CSVD have been identified. These imaging findings, best characterized on magnetic resonance imaging (MRI), include some combination of white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Though some cohorts have reported that participants with type 2 diabetes mellitus (T2DM), an important risk factor for CSVD, may have a distinct neuroradiologic phenotype, this relationship is not well-characterized...
January 17, 2017: Systematic Reviews
Joe Cambray
The complexity associated with deep interconnectedness in nature is beginning to be articulated and elaborated in the field of ecological studies. While some parallels to the psyche have been made and the field of Eco-psychology has been developing, Jung's explicit contribution by way of the image of rhizomes has not been considered in detail. Philosopher Gilles Deleuze acknowledges borrowing the term from Jung, though he disagreed with Jung's Empedoclean use of the term. The paper presents some fundamental properties of rhizomes along with contemporary scientific research on mycorrhizal (fungal) networks...
February 2017: Journal of Analytical Psychology
Kristof T Schütt, Farhad Arbabzadah, Stefan Chmiela, Klaus R Müller, Alexandre Tkatchenko
Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text and image search, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding quantum many-body systems? Here we develop an efficient deep learning approach that enables spatially and chemically resolved insights into quantum-mechanical observables of molecular systems. We unify concepts from many-body Hamiltonians with purpose-designed deep tensor neural networks, which leads to size-extensive and uniformly accurate (1 kcal mol(-1)) predictions in compositional and configurational chemical space for molecules of intermediate size...
January 9, 2017: Nature Communications
F Edward Boas, Govindarajan Srimathveeravalli, Jeremy C Durack, Elena A Kaye, Joseph P Erinjeri, Etay Ziv, Majid Maybody, Hooman Yarmohammadi, Stephen B Solomon
PURPOSE: To create and validate a planning tool for multiple-probe cryoablation, using simulations of ice ball size and shape for various ablation probe configurations, ablation times, and types of tissue ablated. MATERIALS AND METHODS: Ice ball size and shape was simulated using the Pennes bioheat equation. Five thousand six hundred and seventy different cryoablation procedures were simulated, using 1-6 cryoablation probes and 1-2 cm spacing between probes. The resulting ice ball was measured along three perpendicular axes and recorded in a database...
January 3, 2017: Cardiovascular and Interventional Radiology
Sathyakrishna Basavapatna Ramakrishnaiah, Santosh Singh Rajput, Nayar Sajeeth Gopinathan
Epidermoid cysts are common benign subcutaneous lesion also termed as epidermal cysts. Epidermoid cyst are commonly seen in hairy regions of body like scalp, face and scrotum, can be single or multiple, but rarely can occur in glabrous skin of palm and sole. They are known to result from progressive cystic ectasia of the infundibular portion of hair follicle but the pathogenesis in palmo-plantar epidermoid cyst differs that is traumatic sequestration of epidermal elements into dermis. Here, we report a case of 30-year-old female presented with complaints of swelling in her left sole...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
A Rodrigues, D Sawkey, Q Wu
PURPOSE: DEAR is a radiation therapy technique utilizing synchronized motion of gantry and couch during delivery to optimize dose distribution homogeneity and penumbra for treatment of superficial disease. Dose calculation for DEAR is not yet supported by commercial TPSs. The purpose of this study is to demonstrate the feasibility of using a web-based Monte Carlo (MC) simulation tool (VirtuaLinac) to calculate dose distributions for a DEAR delivery. METHODS: MC simulations were run through VirtuaLinac, which is based on the GEANT4 platform...
June 2016: Medical Physics
M Moriyama, Y Murakami, M Ohki, K Tokumori, S Okamoto
PURPOSE: The dcm4chee is an open source software for making a high-performance DICOM server. The process of dcm4chee is recorded in a log as text file. It takes a lot of time to read the log file for checking DICOM server performance. Therefore, we made a log analyzer for dcm4chee, which compiles the statistics on image transfer between DICOM server and imaging devices. METHODS: The log analysis program was written in Perl (practical extraction and report language)...
June 2016: Medical Physics
K Wijesooriya, N Liyanage, M Kaluarachchi, D Sawkey
PURPOSE: Patient dose far from the treatment field is comprised of scatter from within the patient, and treatment head leakage. We quantify the treatment head leakage for TrueBeam linear accelerator for 6X and 6X-FFF beams by comparing measurements to Monte Carlo simulations for a variety of jaw sizes and collimator rotations. This work is conceptually similar to that of Kry et al. (Medical Physics 2006; 33: 4405), who considered a Clinac linear accelerator. METHODS: Measurements were made using an EXRADIN A101 ion chamber positioned in the patient plane, at distances up to 100 cm from isocenter...
June 2016: Medical Physics
Jun Li, Shufen Li, Ruifang Chen, Xin Lu
This study is aimed to conduct a meta-analysis to evaluate the prognostic value of lymphovascular space invasion(LVSI) and to explore the potential association of SNAI1 and SNAI2 with LVSI in ovarian cancer. A systematic literature search in PubMed, ISI Web of Science, and Medline was conducted to identify relevant studies assessing the prognostic value of LVSI in ovarian cancer. The main outcomes analyzed were progression free survival/disease free survival and overall survival. TCGA database was used to explore the potential link of SNAI1 and SNAI2 with LVSI status...
December 25, 2016: Oncotarget
Maike Schulz, Matthias Romppel, Gesine Grande
OBJECTIVES: Empirical research on the relationship between the built environment and health is increasing at a tremendous pace. However, findings from Anglo-American countries may not apply to the European context. Therefore, we systematically reviewed the existing evidence on the role of the built environment for leading risk factors and health behavior in Germany. METHODS: Through an extensive search via PubMed and Web of Science, using predefined selection criteria, two independent reviewers identified 25 empirical studies...
December 29, 2016: Journal of Public Health
Hongyan Gu, Lulu Sun, Rui Jin, Fang Li, Yuanyuan Wei, Zhengzheng Xie
The closed pharmaceutical counseling room was so hard to be established for most of hospitals in China since limited space in the out-patient lobby, which dramatically affected the qualification of medication consultant. Few reports studied the importance of closed pharmaceutical counseling room construction.To investigate the necessary of closed pharmaceutical counseling room construction in the outpatient lobby.The closed pharmaceutical counseling room was established and equipped with hospital electronic information system, patient education flashes, and we-Chat in web...
December 2016: Medicine (Baltimore)
Jinlong He, Yunji Wang, Hongtao Hu, Qian Liao, Weiyi Zhang, Xuerong Xiang, Xiaoping Fan
OBJECTIVE: This study is aimed at assembling, through a systematic review and meta-analysis, scientific evidence related to the effects of mandibular setback (MdS) surgery and bimaxillary surgery for the correction of Class III malocclusion on the cross-sectional area (CSA) and volume of the upper airway as assessed using CT. METHODS: An electronic search was conducted on Cochrane Library, EMBASE, PubMed, Scopus and Web of Science up to June 20, 2016. The inclusion criteria were prospective or retrospective studies, with the aim of comparing the impact on the upper airway space of orthognathic surgery for the treatment of the skeletal class III malocclusion...
December 24, 2016: International Journal of Surgery
Sean J Blamires, Matthew Hasemore, Penny J Martens, Michael M Kasumovic
The adaptive benefits of extended phenotypic plasticity are imprecisely defined due to a paucity of experiments examining traits that are manipulable and measurable across environments. Spider webs are often used as models to explore the adaptive benefits of variations in extended phenotypes across environments. Nonetheless, our understanding of the adaptive nature of the plastic responses of spider webs is impeded when web architectures and silk physicochemical properties appear to co-vary. An opportunity to examine this co-variation is presented by modifying prey items while measuring web architectures and silk physiochemical properties...
December 23, 2016: Journal of Experimental Biology
Laura B Catano, Mark B Barton, Kevin M Boswell, Deron E Burkepile
Non-consumptive effects (NCEs) of predators occur as prey alters their habitat use and foraging decisions to avoid predation. Although NCEs are recognized as being important across disparate ecosystems, the factors influencing their strength and importance remain poorly understood. Ecological context, such as time of day, predator identity, and prey condition, may modify how prey species perceive and respond to risk, thereby altering NCEs. To investigate how predator identity affects foraging of herbivorous coral reef fishes, we simulated predation risk using fiberglass models of two predator species (grouper Mycteroperca bonaci and barracuda Sphyraena barracuda) with different hunting modes...
December 22, 2016: Oecologia
Dafang Zhang
OBJECTIVE: Spinal arachnoid webs are a rare variant of spinal arachnoid cysts where one or multiple focal membranes of arachnoid tissue obstruct the subarachnoid space. Only 11 prior cases of arachnoid webs have been reported in the literature. Our objective is to present a series of three consecutive cases of arachnoid webs from our institution and to review the literature on this rare condition to provide recommendations for its management. METHODS: A retrospective chart review was performed for three consecutive cases of intradural arachnoid webs causing spinal cord compression at our institution, with inconclusive preoperative imaging, treatment with surgical decompression and resection...
December 16, 2016: World Neurosurgery
Kyle H Elliott, John E Elliott
Mercury (Hg) is a neurotoxin that can be particularly harmful to top predators because it biomagnifies through the food web. Due to variation in the food web structure, variation in Hg exposure in predators may represent variation in diet rather than Hg availability. We measured Hg in eggs from six seabird species (N = 537) over 47 years. In contrast to expectation, storm-petrels feeding partially on invertebrates had the highest Hg burden while herons feeding on large fish had the lowest Hg burden. A multiple regression showed that Hg correlated with δ(34)S (R(2) = 0...
December 20, 2016: Environmental Science & Technology
Michiel Van Bel, Frederik Coppens
Selecting and filtering a reference expression and interaction dataset when studying specific pathways and regulatory interactions can be a very time-consuming and error-prone task. In order to reduce the duplicated efforts required to amass such datasets, we have created the CORNET (CORrelation NETworks) platform which allows for easy access to a wide variety of data types: coexpression data, protein-protein interactions, regulatory interactions, and functional annotations. The CORNET platform outputs its results in either text format or through the Cytoscape framework, which is automatically launched by the CORNET website...
2017: Methods in Molecular Biology
Jürgen Kasper, Adrian van de Roemer, Jana Pöttgen, Anne Rahn, Imke Backhus, Yasemin Bay, Sascha Köpke, Christoph Heesen
OBJECTIVE: Patients making treatment decisions require understandable evidence-based information. However, evidence on graphical presentation of benefits and side-effects of medical treatments is not conclusive. The study evaluated a new space-saving format, CLARIFIG (clarifying risk figures), aiming to facilitate accuracy of comprehension. METHODS: CLARIFIG displays groups of patients with and without treatment benefits as coloured sectors of a proportional bar graph representing in total 100 patients...
December 16, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
Yu-Feng Lin, Chih-Wen Cheng, Chung-Shiuan Shih, Jenn-Kang Hwang, Chin-Sheng Yu, Chih-Hao Lu
The structure of a protein determines its biological function(s) and its interactions with other factors; the binding regions tend to be conserved in sequence and structure, and the interacting residues involved are usually in close 3D space. The Protein Data Bank currently contains more than 110 000 protein structures, approximately one-third of which contain metal ions. Identifying and characterizing metal ion-binding sites is thus essential for investigating a protein's function(s) and interactions. However, experimental approaches are time-consuming and costly...
December 27, 2016: Journal of Chemical Information and Modeling
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