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https://www.readbyqxmd.com/read/28524117/ebutterfly-leveraging-massive-online-citizen-science-for-butterfly-consevation
#1
Kathleen L Prudic, Kent P McFarland, Jeffrey C Oliver, Rebecca A Hutchinson, Elizabeth C Long, Jeremy T Kerr, Maxim Larrivée
Data collection, storage, analysis, visualization, and dissemination are changing rapidly due to advances in new technologies driven by computer science and universal access to the internet. These technologies and web connections place human observers front and center in citizen science-driven research and are critical in generating new discoveries and innovation in such fields as astronomy, biodiversity, and meteorology. Research projects utilizing a citizen science approach address scientific problems at regional, continental, and even global scales otherwise impossible for a single lab or even a small collection of academic researchers...
May 18, 2017: Insects
https://www.readbyqxmd.com/read/28511646/emergence-of-microbial-diversity-due-to-cross-feeding-interactions-in-a-spatial-model-of-gut-microbial-metabolism
#2
Milan J A van Hoek, Roeland M H Merks
BACKGROUND: The human gut contains approximately 10(14) bacteria, belonging to hundreds of different species. Together, these microbial species form a complex food web that can break down nutrient sources that our own digestive enzymes cannot handle, including complex polysaccharides, producing short chain fatty acids and additional metabolites, e.g., vitamin K. Microbial diversity is important for colonic health: Changes in the composition of the microbiota have been associated with inflammatory bowel disease, diabetes, obesity and Crohn's disease, and make the microbiota more vulnerable to infestation by harmful species, e...
May 16, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28507859/the-double-volar-flap-technique-for-aesthetic-repair-of-syndactyly-and-polysyndactyly-of-toe-without-skin-grafting
#3
Toru Miyanaga, Kenichi Shimada, Miyuki Kishibe, Masanobu Yamashita, Akiko Yamashita
BACKGROUND: Aesthetic repair of syndactyly of the toes is desirable because patients may have psychological concerns about its appearance. There are 2 important factors for the aesthetic repair of syndactyly of the toe. One is to hide the operative scar from the visual site (dorsal site), whereas the other is to create an interdigital space close to the normal anatomical skin characteristics (2 general types of skin: glabrous and hairy). METHODS: In total, 12 patients (4 males and 8 females) with 15 syndactylous webs were operated on by using the double volar flap technique...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28498966/genprobis-web-server-for-mapping-of-sequence-variants-to-protein-binding-sites
#4
Janez Konc, Blaz Skrlj, Nika Erzen, Tanja Kunej, Dusanka Janezic
Discovery of potentially deleterious sequence variants is important and has wide implications for research and generation of new hypotheses in human and veterinary medicine, and drug discovery. The GenProBiS web server maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein-protein, protein-nucleic acid, protein-compound, and protein-metal ion binding sites. The concept of a protein-compound binding site is understood in the broadest sense, which includes glycosylation and other post-translational modification sites...
May 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28494745/global-view-on-rare-diseases-a-mini-review
#5
Blanka Klimova, Martin Valis, Michael Storek, Kamil Kuca
BACKGROUND: Rare diseases are often serious, life-threatening and debilitating group of disorders. Nowadays, there are approximately 8,000 rare diseases and it is estimated that 350 million people are affected by these conditions worldwide. Unfortunately, rare diseases are quite complex and chronic, only a small number of these diseases can be relevantly diagnosed and treated, and lifelong treatment is often required. OBJECTIVE: The purpose of this mini review is to explore the issue of rare diseases, describe their classification, discuss the current treatment and management and set future research in this field...
May 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28487275/a-phenome-database-neauhlfpd-designed-and-constructed-for-broiler-lines-divergently-selected-for-abdominal-fat-content
#6
Li Min, Dong Xiangyu, Liang Hao, Leng Li, Zhang Hui, Wang Shouzhi, Li Hui, Du Zhi-Qiang
Effective management and analysis of precisely recorded phenotypic traits are important components of the selection and breeding of superior livestocks. Over two decades, we divergently selected chicken lines for abdominal fat content at Northeast Agricultural University (Northeast Agricultural University High and Low Fat, NEAUHLF), and collected large volume of phenotypic data related to the investigation on molecular genetic basis of adipose tissue deposition in broilers. To effectively and systematically store, manage and analyze phenotypic data, we built the NEAUHLF Phenome Database (NEAUHLFPD)...
May 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28485226/web-review-arthur-s-place
#7
Simon Stones
A similar Facebook group, Arthur's Place, provides a space for people with RMDs aged up to 35 to support each other.
May 9, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28481897/macroscale-patterns-in-body-size-of-intertidal-crustaceans-provide-insights-on-climate-change-effects
#8
Eduardo Jaramillo, Jenifer E Dugan, David M Hubbard, Heraldo Contreras, Cristian Duarte, Emilio Acuña, David S Schoeman
Predicting responses of coastal ecosystems to altered sea surface temperatures (SST) associated with global climate change, requires knowledge of demographic responses of individual species. Body size is an excellent metric because it scales strongly with growth and fecundity for many ectotherms. These attributes can underpin demographic as well as community and ecosystem level processes, providing valuable insights for responses of vulnerable coastal ecosystems to changing climate. We investigated contemporary macroscale patterns in body size among widely distributed crustaceans that comprise the majority of intertidal abundance and biomass of sandy beach ecosystems of the eastern Pacific coasts of Chile and California, USA...
2017: PloS One
https://www.readbyqxmd.com/read/28475578/tiled-vector-data-model-for-the-geographical-features-of-symbolized-maps
#9
Lin Li, Wei Hu, Haihong Zhu, You Li, Hang Zhang
Electronic maps (E-maps) provide people with convenience in real-world space. Although web map services can display maps on screens, a more important function is their ability to access geographical features. An E-map that is based on raster tiles is inferior to vector tiles in terms of interactive ability because vector maps provide a convenient and effective method to access and manipulate web map features. However, the critical issue regarding rendering tiled vector maps is that geographical features that are rendered in the form of map symbols via vector tiles may cause visual discontinuities, such as graphic conflicts and losses of data around the borders of tiles, which likely represent the main obstacles to exploring vector map tiles on the web...
2017: PloS One
https://www.readbyqxmd.com/read/28475326/spectrophotometric-analysis-of-phenolic-compounds-in-grapes-and-wines
#10
Jose Luis Aleixandre-Tudo, Astrid Buica, Helene Nieuwoudt, Jose Luis Aleixandre, Wessel du Toit
Phenolic compounds are of crucial importance for red wine color and mouthfeel attributes. A large number of enzymatic and chemical reactions involving phenolic compounds take place during winemaking and aging. Despite the large number of published analytical methods for phenolic analyses, the values obtained may vary considerably. In addition, the existing scientific knowledge needs to be updated, but also critically evaluated and simplified for newcomers and wine industry partners. The most used and widely cited spectrophotometric methods for grape and wine phenolic analysis were identified through a bibliometric search using the Science Citation Index-Expanded (SCIE) database accessed through the Web of Science (WOS) platform from Thompson Reuters...
May 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28472495/c-spade-a-web-tool-for-interactive-analysis-and-visualization-of-drug-screening-experiments-through-compound-specific-bioactivity-dendrograms
#11
Balaguru Ravikumar, Zaid Alam, Gopal Peddinti, Tero Aittokallio
The advent of polypharmacology paradigm in drug discovery calls for novel chemoinformatic tools for analyzing compounds' multi-targeting activities. Such tools should provide an intuitive representation of the chemical space through capturing and visualizing underlying patterns of compound similarities linked to their polypharmacological effects. Most of the existing compound-centric chemoinformatics tools lack interactive options and user interfaces that are critical for the real-time needs of chemical biologists carrying out compound screening experiments...
May 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28468262/scalability-issues-for-remote-sensing-infrastructure-a-case-study
#12
Yang Liu, Sean Picard, Carey Williamson
For the past decade, a team of University of Calgary researchers has operated a large "sensor Web" to collect, analyze, and share scientific data from remote measurement instruments across northern Canada. This sensor Web receives real-time data streams from over a thousand Internet-connected sensors, with a particular emphasis on environmental data (e.g., space weather, auroral phenomena, atmospheric imaging). Through research collaborations, we had the opportunity to evaluate the performance and scalability of their remote sensing infrastructure...
April 29, 2017: Sensors
https://www.readbyqxmd.com/read/28467051/openmsi-arrayed-analysis-toolkit-analyzing-spatially-defined-samples-using-mass-spectrometry-imaging
#13
Markus de Raad, Tristan de Rond, Oliver Rübel, Jay D Keasling, Trent R Northen, Benjamin P Bowen
Mass spectrometry imaging (MSI) has primarily been applied in localizing biomolecules within biological matrices. Although well-suited, the application of MSI for comparing thousands of spatially defined spotted samples has been limited. One reason for this is a lack of suitable and accessible data processing tools for the analysis of large arrayed MSI sample sets. The OpenMSI Arrayed Analysis Toolkit (OMAAT), is a software package that addresses the challenges of analyzing spatially defined samples in MSI datasets...
May 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28460065/sbspksv2-structure-based-sequence-analysis-of-polyketide-synthases-and-non-ribosomal-peptide-synthetases
#14
Shradha Khater, Money Gupta, Priyesh Agrawal, Neetu Sain, Jyoti Prava, Priya Gupta, Mansi Grover, Narendra Kumar, Debasisa Mohanty
Genome guided discovery of novel natural products has been a promising approach for identification of new bioactive compounds. SBSPKS web-server has been a valuable resource for analysis of polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) gene clusters. We have developed an updated version - SBSPKSv2 which is based on comprehensive analysis of sequence, structure and secondary metabolite chemical structure data from 311 experimentally characterized PKS/NRPS gene clusters with known biosynthetic products...
April 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453644/traitrateprop-a-web-server-for-the-detection-of-trait-dependent-evolutionary-rate-shifts-in-sequence-sites
#15
Eli Levy Karin, Haim Ashkenazy, Susann Wicke, Tal Pupko, Itay Mayrose
Understanding species adaptation at the molecular level has been a central goal of evolutionary biology and genomics research. This important task becomes increasingly relevant with the constant rise in both genotypic and phenotypic data availabilities. The TraitRateProp web server offers a unique perspective into this task by allowing the detection of associations between sequence evolution rate and whole-organism phenotypes. By analyzing sequences and phenotypes of extant species in the context of their phylogeny, it identifies sequence sites in a gene/protein whose evolutionary rate is associated with shifts in the phenotype...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28444340/ligpargen-web-server-an-automatic-opls-aa-parameter-generator-for-organic-ligands
#16
Leela S Dodda, Israel Cabeza de Vaca, Julian Tirado-Rives, William L Jorgensen
The accurate calculation of protein/nucleic acid-ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions. Despite the progress made in force fields, small molecule parameterization remains an open problem due to the magnitude of the chemical space; the most critical issue is the estimation of a balanced set of atomic charges with the ability to reproduce experimental properties. The LigParGen web server provides an intuitive interface for generating OPLS-AA/1...
April 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28442452/homestyles-a-web-based-childhood-obesity-prevention-program-for-families-with-preschool-children-protocol-for-a-randomized-controlled-trial
#17
Carol Byrd-Bredbenner, Jennifer Martin-Biggers, Mallory Koenings, Virginia Quick, Nobuko Hongu, John Worobey
BACKGROUND: The home environment is where young children spend most of their time, and is critically important to supporting behaviors that promote health and prevent obesity. However, the home environment and lifestyle patterns remain understudied, and few interventions have investigated parent-led makeovers designed to create home environments that are supportive of optimal child health and healthy child weights. OBJECTIVE: The aim of the HomeStyles randomized controlled trial (RCT) is to determine whether the Web-based HomeStyles intervention enables and motivates parents to shape the weight-related aspects of their home environments and lifestyle behavioral practices (diet, exercise, and sleep) to be more supportive of their preschool children's optimal health and weight...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28427994/global-dynamics-in-a-stoichiometric-food-chain-model-with-two-limiting-nutrients
#18
Ming Chen, Meng Fan, Yang Kuang
Ecological stoichiometry studies the balance of energy and multiple chemical elements in ecological interactions to establish how the nutrient content affect food-web dynamics and nutrient cycling in ecosystems. In this study, we formulate a food chain with two limiting nutrients in the form of a stoichiometric population model. A comprehensive global analysis of the rich dynamics of the targeted model is explored both analytically and numerically. Chaotic dynamic is observed in this simple stoichiometric food chain model and is compared with traditional model without stoichiometry...
April 18, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28425075/technical-note-real-time-web-based-wireless-visual-guidance-system-for-radiotherapy
#19
Danny Lee, Siyong Kim, Jatinder R Palta, Taeho Kim
Describe a Web-based wireless visual guidance system that mitigates issues associated with hard-wired audio-visual aided patient interactive motion management systems that are cumbersome to use in routine clinical practice. Web-based wireless visual display duplicates an existing visual display of a respiratory-motion management system for visual guidance. The visual display of the existing system is sent to legacy Web clients over a private wireless network, thereby allowing a wireless setting for real-time visual guidance...
April 19, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28419807/otolaryngology-residency-program-research-resources-and-scholarly-productivity
#20
Jennifer A Villwock, Chelsea S Hamill, Brian D Nicholas, Jesse T Ryan
Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded...
April 1, 2017: Otolaryngology—Head and Neck Surgery
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