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https://www.readbyqxmd.com/read/29783188/%C3%AE-pyrone-compounds-flavonoids-and-maltol-glucoside-derivatives-from-herniaria-glabra-l-collected-in-the-ternopil-region-of-the-ukraine
#1
Solomiia Kozachok, Łukasz Pecio, Joanna Kolodziejczyk-Czepas, Svitlana Marchyshyn, Pawel Nowak, Jarosław Mołdoch, Wiesław Oleszek
The phytochemical investigation of the whole plant extracts of Herniaria glabra L. (Caryophyllaceae) led to the identification and isolation of four known flavonoids, one known and three undescribed maltol derivatives, and benzyl β-gentiobioside. The structures were established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. For the first time in Herniaria genus, as well as in Caryophylaceae family the presence of apiorutin {quercetin 3-O-[(D-apio-β-d-furanosyl-(1 → 2)-O-[-α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside]} and licoagroside B {maltol 3-O-[6-O-(3-hydroxy-3-methylglutaroyl)]-β-d-glucopyranoside} were revealed...
May 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783017/the-hydro-ethanolic-extract-of-acacia-seyal-mimosaceae-stem-barks-induced-death-in-an-er-negative-breast-cancer-cell-line-by-the-intrinsic-pathway-of-apoptosis-and-inhibited-cell-migration
#2
Stephane Zingue, Thomas Michel, Julia Cisilotto, Alain Brice Tueche, Derek Tantoh Ndinteh, Leônidas João Mello, Dieudonné Njamen, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Despite the significant developments occurring in the treatment of cancer, it still remains the second deadly disease, responsible for 8.2 million deaths every year. Various natural substances have been studied for active molecules of tumor suppression in the past and the tropical flora, by its diversity, continues to provide new antitumor drugs. Acacia seyal is a plant used in Cameroonian traditional system to treat cancer. It exhibited cytotoxic effects towards human breast adenocarcinoma cells...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29782822/simultaneous-determination-of-intestinal-permeability-and-potential-drug-interactions-of-complex-mixtures-using-caco-2-cells-and-high-resolution-mass-spectrometry-studies-with-rauwolfia-serpentina-extract
#3
Thomas J Flynn, Sanah N Vohra
Caco-2 cells are a commonly used model for estimating the intestinal bioavailability of single chemical entity pharmaceuticals. Caco-2 cells, when induced with calcitriol, also express other biological functions such as phase I (CYP) and phase II (glucuronosyltransferases) drug metabolizing enzymes which are relevant to drug-supplement interactions. Intestinal bioavailability is an important factor in the overall safety assessment of products consumed orally. Foods, including herbal dietary supplements, are complex substances with multiple chemical components...
May 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29782649/development-of-an-hplc-dad-method-for-the-determination-of-five-alkaloids-in-stephania-yunnanensis-lo-and-in-rat-plasma-after-oral-dose-of-stephania-yunnanensis-lo-extracts
#4
Aiyi Xin, Yaming Zhang, Yanxia Zhang, Duolong Di, Junxi Liu
For the rational utilization and the quantitative quality control of the Stephania yunnanensis Lo, an HPLC-DAD method was developed for the quantitative and simultaneous determination of five alkaloids in rat plasma (stepharine, sinomenine, palmatine, isocorydine and tetrahydropalmatine), which were the main active chemical constituents of this plant and belong to four kinds of isoquinoline-type alkaloids (protoberberine, morphine, aporphine and protaporphine alkaloids). The contents of five alkaloids ranged from 0...
May 21, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29782021/exploring-the-root-microbiome-extracting-bacterial-community-data-from-the-soil-rhizosphere-and-root-endosphere
#5
Tuesday Simmons, Daniel F Caddell, Siwen Deng, Devin Coleman-Derr
The intimate interaction between plant host and associated microorganisms is crucial in determining plant fitness, and can foster improved tolerance to abiotic stresses and diseases. As the plant microbiome can be highly complex, low-cost, high-throughput methods such as amplicon-based sequencing of the 16S rRNA gene are often preferred for characterizing its microbial composition and diversity. However, the selection of appropriate methodology when conducting such experiments is critical for reducing biases that can make analysis and comparisons between samples and studies difficult...
May 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781354/effects-and-possible-mechanisms-of-alpinia-officinarum-ethanol-extract-on-indomethacin-induced-gastric-injury-in-rats
#6
Jingwen Gong, Zhong Zhang, Xuguang Zhang, Feng Chen, Yinfeng Tan, Hailong Li, Jie Jiang, Junqing Zhang
CONTEXT: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known. OBJECTIVE: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model. MATERIAL AND METHODS: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29781304/a-phytochemical-study-of-the-cuphea-glutinosa-from-southern-brazil-na-k-atpase-activity-inhibition-and-antioxidant-properties
#7
Adriana M Zago, Fabiano B Carvalho, Jessié Martins Gutierres, Crystiani Bohnert, Marilda da Cruz Fernandes, Liziane M Morandini, Helena S Coelho, Aline O Fogaça, Cinthia M Andrade, Marco A Mostardeiro, Ionara I Dalcol, Ademir F Morel
This study investigated the antioxidant activity of Cuphea glutinosa (CG) and its effect on Na+ , K+ -ATPase from cardiac muscle. The ethanolic extract showed higher antioxidant capacity compared to aqueous and ethyl acetate fraction. Ethyl acetate fraction showed β-sitosterol-3-O-β-glucoside, kaempferol, quercetin, isoquercetin, gallic acid methyl ester, and gallic acid. The ethanolic extract also reduced the Na+ ,K+ -ATPase activity. CG presented a promising antioxidant activity and inhibitory effect on the Na+ , K+ -ATPase activity, supporting biochemical evidences the popular use of this plant in the treatment of heart failure...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781300/quaternary-ammonium-compounds-in-roots-and-leaves-of-capparis-spinosa-l-from-saudi-arabia-and-italy-investigation-by-hplc-ms-and-1-h-nmr
#8
Amal Al-Tamimi, Mohamad Khatib, Giuseppe Pieraccini, Nadia Mulinacci
Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in protecting against abiotic stress. Aim of this work was to determine QACs in root and leaves of caper from two proveniences. The presence of stachydrine, choline, glycine betaine and homo-stachydrine has been confirmed by high resolution MS, while 1 H NMR was applied to quantify the main QACs in the aqueous extracts...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29780682/-nitraria-schoberi-l-hairy-root-culture-as-a-source-of-compounds-with-antiviral-activity-against-influenza-virus-subtypes-%C3%B0-h5n1-and-%C3%B0-h3n2
#9
Tatiana Zheleznichenko, Evgenii Banaev, Sergey Asbaganov, Maria Voronkova, Tatiana Kukushkina, Ekaterina Filippova, Natalia Mazurkova, Larisa Shishkina, Tatyana Novikova
The hairy root culture of halophyte Nitraria schoberi was obtained by transforming seedlings' primary leaves with a wild strain of Agrobacterium rhizogenes 15834 SWISS (transformation frequency was 78.7%). The roots' transgenic status was confirmed by PCR analysis using rolB -, rolC -, virC -, virD1 -specific primers. There was a significant increase in the biosynthesis of flavonoids, hydroxycinnamic acids, pectins, protopectins and saponins in hairy roots as compared to intact plant roots. The сatechin content in ethanol extracts of transformed roots' exceeded this factor 3...
June 2018: 3 Biotech
https://www.readbyqxmd.com/read/29780217/the-impact-of-media-composition-on-production-of-flavonoids-in-agitated-shoot-cultures-of-the-three-hypericum-perforatum-l-cultivars-elixir-helos-and-topas
#10
Inga Kwiecień, Julia Smolin, Ludger Beerhues, Halina Ekiert
The aims of the study were to evaluate the effect of media composition on the growth potential and morphology of the in vitro cultured biomass of three cultivars of Hypericum perforatum , and on the production of flavonoids. Agitated shoot cultures were maintained in parallel on Linsmaier and Skoog (LS) and Murashige and Skoog (MS) media supplemented with 0.1-3.0 mg L-1 of α-naphthaleneacetic acid and 6-benzylaminopurine. Methanolic extracts from the biomass collected after 3-wk growth cycles were analyzed quantitatively, for 21 flavonoids using high performance liquid chromatography...
2018: In Vitro Cellular & Developmental Biology. Plant: Journal of the Tissue Culture Association
https://www.readbyqxmd.com/read/29779374/molecularly-imprinted-polymers-for-compound-specific-isotope-analysis-of-polar-organic-micropollutants-in-aquatic-environments
#11
Rani Bakkour, Jakov Bolotin, Börje Sellergren, Thomas B Hofstetter
Compound-specific isotope analysis (CSIA) of polar organic micropollutants in environmental waters requires a processing of large sample volumes to obtain the required analyte masses for analysis by gas chromatography / isotope-ratio mass spectrometry (GC/IRMS). However, the accumulation of organic matter of unknown isotopic composition in standard enrichment procedures currently compromises the accurate determination of isotope ratios. We explored the use of molecularly-imprinted polymers (MIPs) for selective analyte enrichment for 13C/12C and 15N/14N ratio measurements by GC/IRMS using 1H-benzotriazole, a typical corrosion inhibitor in dishwashing detergents, as example of a widely detected polar organic micropollutant...
May 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29779268/variation-in-polyphenolic-profiles-antioxidant-and-antimicrobial-activity-of-different-achillea-species-as-natural-sources-of-antiglycative-compounds
#12
Mahvash Afshari, Mehdi Rahimmalek, Mehran Miroliaei
A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC50 = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC...
May 19, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29778978/tough-love-accommodating-intracellular-bacteria-through-directed-secretion-of-antimicrobial-peptides-during-the-nitrogen-fixing-symbiosis
#13
REVIEW
Christina Stonoha-Arther, Dong Wang
The symbiosis formed by nitrogen-fixing bacteria with plant hosts mainly in the legume family involves a very intimate interaction. Within the symbiotic organ (the nodule) the bacteria are fully internalized by the host cell to become an intracellular organelle surrounded by a host-derived membrane. This arrangement is probably necessary for the efficient provision of energy and the sequestration of free oxygen molecules, two conditions required for sustained nitrogen fixation. Recent advances made in model legume species, such as Medicago truncatula, are beginning to uncover the genetic components allowing rhizobia to access the host cytoplasm and establish chronic intracellular infections without overt detrimental effects...
May 17, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29778538/naringenin-exhibits-the-protective-effect-on-cardiac-hypertrophy-via-eets-ppars-activation-in-streptozocin-induced-diabetic-mice
#14
Jie Zhang, Hongmei Qiu, Jiajun Huang, Shumei Ding, Bo Huang, Qin Wu, Qingsong Jiang
Cardiac hypertrophy is one of the key structural changes in diabetic cardiomyopathy. Naringenin, a dihydroflavonoid extracted from citrus plants with multiple pharmacological activities, yet the underlying effects on diabetic cardiac hypertrophy remain unclear. This study aimed to evaluate the potential effects of naringenin on cardiac hypertrophy in diabetic mice. Long-term high-fat feeding combined with streptozotocin resulted in cardiac hypertrophy after a diabetic model has been established for 4 weeks in mice, which were improved by naringenin supplementation (25 or 75 mg/kg/day, i...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29778168/development-of-a-novel-myconanomining-approach-for-the-recovery-of-agriculturally-important-elements-from-jarosite-waste
#15
Ankita Bedi, Braj Raj Singh, Sunil K Deshmukh, Nisha Aggarwal, Colin J Barrow, Alok Adholeya
In this study, an ecofriendly and economically viable waste management approach have been attempted towards the biosynthesis of agriculturally important nanoparticles from jarosite waste. Aspergillus terreus strain J4 isolated from jarosite (waste from Debari Zinc Smelter, Udaipur, India), showed good leaching efficiency along with nanoparticles (NPs) formation under ambient conditions. Fourier-transform infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM) confirmed the formation of NPs...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#16
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777901/interrogation-of-ethnomedicinal-plants-for-synthetic-lethality-effects-in-combination-with-deficiency-in-the-dna-repair-endonuclease-rad1-using-a-yeast-cell-based-assay
#17
Hsu Mon Aung, Chananya Huangteerakul, Wittaya Panvongsa, Amornrat N Jensen, Arthit Chairoungdua, Suchada Sukrong, Laran T Jensen
ETHNOPHARMACOLOGICAL RELEVANCE: Plant materials used in this study were selected based on the ethnobotanical literature. Plants have either been utilized by Thai practitioners as alternative treatments for cancer or identified to exhibit anti-cancer properties. AIM OF THE STUDY: To screen ethnomedicinal plants using a yeast cell-based assay for synthetic lethal interactions with cells deleted for RAD1, the yeast homologue of human ERCC4 (XPF) MATERIALS AND METHODS: Ethanolic extracts from thirty-two species of medicinal plants utilized in Thai traditional medicine were screened for synthetic lethal/sick interactions using a yeast cell-based assay...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777813/polyphenolic-polysaccharide-conjugates-from-flowers-and-fruits-of-single-seeded-hawthorn-crataegus-monogyna-jacq-chemical-profiles-and-mechanisms-of-anticoagulant-activity
#18
Izabela Pawlaczyk-Graja
The polyphenolic-polysaccharide conjugates were isolated from flowers and fruits of medicinal plant Crataegus monogyna Jacq. (Lindm.) by the alkaline extraction, followed by neutralization, partitioning with organic solvents and dialysis against water. The isolates from flowers as well as from fruits were homogenous macromolecular compounds, with a molecular weight over 760 × 103  g/mol and 970 × 103  g/mol, respectively, what was assessed in HPGPC analysis. Both products were characterized spectrophotometrically, and by GLC-MS, FT-IR and NMR techniques...
May 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29777739/alkaline-treatment-of-resting-spores-prior-to-dna-extraction-improves-the-purity-of-plasmodiophora-brassicae-dna
#19
Yalong Yang, Kher Zahr, Michael W Harding, Stephen E Strelkov, Krista Zuzak, David Feindel, Jie Feng
A commonly used protocol for DNA extraction from Plasmodiophora brassicae was modified by adding an alkaline treatment step to increase the purity of resting spores. The quality of DNA extracted by the modified protocol was improved due to the removal of DNA contamination from host plant cells and other microorganisms.
May 16, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29777494/residue-behavior-and-risk-assessment-of-thifluzamide-in-the-maize-field-ecosystem
#20
Cong Ma, Zhongdong Liu, Yan Qi, Shanshan Wang, Xiaolin Cao, Jing Wang, Yongxin She, Yong Shao, Jitai Shen, Chao Zhang, Zejun Jiang
In the present work, the dissipation kinetics and final residue levels of thifluzamide in the maize field ecosystem were investigated. Using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction combined with liquid chromatography-tandem mass spectrometric detection (LC-MS/MS), a rapid, sensitive, efficient, and reliable method for extraction and quantitative analysis of thifluzamide residues in maize grain, maize plant, and soil was developed. Satisfactory recoveries of 78.7-97.0% were achieved with relative standard deviations (RSDs) in the range of 1...
May 18, 2018: Environmental Science and Pollution Research International
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