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https://www.readbyqxmd.com/read/27921058/celiac-crisis-associated-with-herpes-simplex-virus-esophagitis
#1
Alan Chen, Christopher M Linz, Julie L Tsay, Ming Jin, Samer S El-Dika
Celiac crisis is a rare presentation of celiac disease that is characterized by life-threatening electrolyte abnormalities, vitamin and mineral deficiencies, and diarrhea. Triggers for celiac crisis include major surgeries, pancreatitis, and infections of cytomegalovirus, and salmonella. A 24-year-old woman presented with celiac crisis associated with severe herpes simplex virus (HSV) esophagitis. This case demonstrates that nutritional deficiencies seen in celiac disease can result in a relative immunodeficiency, which may lead to other infectious complications...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27920756/salmonella-typhimurium-and-multidirectional-communication-in-the-gut
#2
REVIEW
Elena V Gart, Jan S Suchodolski, Thomas H Welsh, Robert C Alaniz, Ronald D Randel, Sara D Lawhon
The mammalian digestive tract is home to trillions of microbes, including bacteria, archaea, protozoa, fungi, and viruses. In monogastric mammals the stomach and small intestine harbor diverse bacterial populations but are typically less populated than the colon. The gut bacterial community (microbiota hereafter) varies widely among different host species and individuals within a species. It is influenced by season of the year, age of the host, stress and disease. Ideally, the host and microbiota benefit each other...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27908385/the-mutagenic-assessment-of-an-electronic-cigarette-and-reference-cigarette-smoke-using-the-ames-assay-in-strains-ta98-and-ta100
#3
D Thorne, I Crooks, M Hollings, A Seymour, C Meredith, M Gaca
Salmonella typhimurium strains TA98 and TA100 were used to assess the mutagenic potential of the aerosol from a commercially available, rechargeable, closed system electronic-cigarette. Results obtained were compared to those for the mainstream smoke from a Kentucky reference (3R4F) cigarette. Two different test matrices were assessed. Aerosol generated from the e-cigarette was trapped on a Cambridge filter pad, eluted in DMSO and compared to cigarette smoke total particulate matter (TPM), which was generated in the same manner for mutagenicity assessment in the Salmonella assay...
December 2016: Mutation Research
https://www.readbyqxmd.com/read/27891531/origanum-majorana-essential-oil-lacks-mutagenic-activity-in-the-salmonella-microsome-and-micronucleus-assays
#4
Andrea Dos Santos Dantas, Luiz Carlos Klein-Júnior, Miriana S Machado, Temenouga N Guecheva, Luciana D Dos Santos, Régis A Zanette, Fernanda B de Mello, João Antonio Pêgas Henriques, João Roberto Braga de Mello
The present study aimed to investigate the in vitro mutagenic activity of Origanum majorana essential oil. The most abundant compounds identified by GC-MS were γ-terpinene (25.73%), α-terpinene (17.35%), terpinen-4-ol (17.24%), and sabinene (10.8%). Mutagenicity was evaluated by the Salmonella/microsome test using the preincubation procedure on TA98, TA97a, TA100, TA102, and TA1535 Salmonella typhimurium strains, in the absence or in the presence of metabolic activation. Cytotoxicity was detected at concentrations higher than 0...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27879336/beyond-antimicrobial-resistance-evidence-for-a-distinct-role-of-the-acrd-efflux-pump-in-salmonella-biology
#5
Michelle M C Buckner, Jessica M A Blair, Roberto M La Ragione, Jane Newcombe, Daniel J Dwyer, Alasdair Ivens, Laura J V Piddock
: For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment conditions, and why have multiple pumps if their only purpose is antimicrobial efflux? Salmonella spp. possess five efflux pump families, including the resistance-nodulation-division (RND) efflux pumps. Notably, the RND efflux pump AcrD has a unique substrate profile, distinct from other Salmonella efflux pumps...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27849183/contribution-of-asparagine-catabolism-to-salmonella-virulence
#6
Patrick A McLaughlin, Michael McClelland, Hee-Jeong Yang, Steffen Porwollik, Lydia Bogomolnaya, Juei-Suei Chen, Helene Andrews-Polymenis, Adrianus W M van der Velden
Salmonellae are pathogenic bacteria that cause significant morbidity and mortality in humans worldwide. Salmonellae establish infection and avoid clearance by the immune system by mechanisms that are not well understood. We previously showed that L-Asparaginase II produced by Salmonella enterica serovar Typhimurium (S Typhimurium) inhibits T cell responses and mediates virulence. In addition, we previously showed that asparagine deprivation such as that mediated by L-Asparaginase II of S Typhimurium causes suppression of activation-induced T cell metabolic reprogramming...
November 14, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27821122/effects-of-chromium-enriched-bacillus-subtilis-kt260179-supplementation-on-chicken-growth-performance-plasma-lipid-parameters-tissue-chromium-levels-cecal-bacterial-composition-and-breast-meat-quality
#7
Jiajun Yang, Kun Qian, Wei Zhang, Yayuan Xu, Yijing Wu
BACKGROUND: Both chromium (Cr) and probiotic bacillus own the virtues of regulating animal metabolism and meat quality. Purpose of this study was to evaluate the efficiency of supplemental Cr and bacillus in the form of chromium-enriched Bacillus subtilis KT260179 (CEBS) on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality. METHODS: Six hundred of 1-day-old Chinese Huainan Partridge chickens were divided into four groups randomly: Control, inorganic Cr, Bacillus subtilis, and CEBS...
November 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27817242/nanoparticle-fullerene-c60-demonstrated-stable-binding-with-antibacterial-potential-towards-probable-targets-of-drug-resistant-salmonella-typhi-a-computational-perspective-and-in-vitro-investigation
#8
Sinosh Skariyachan, Asma Parveen, Shruti Garka
Salmonella typhi, a Gram negative bacterium, has become multidrug resistant (MDR) to wide classes of antibacterials which necessitate an alarming precaution. This study focuses on the binding potential and therapeutic insight of Nano-Fullerene C60 towards virulent targets of Salmonella typhi by computational prediction and preliminary in vitro assays. The clinical isolates of Salmonella typhi were collected and antibiotic susceptibility profiles were assessed. The drug targets of pathogen were selected by rigorous literature survey and gene network analysis by various metabolic network resources...
November 6, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27800482/stabilization-of-the-virulence-plasmid-pslt-of-salmonella-typhimurium-by-three-maintenance-systems-and-its-evaluation-by-using-a-new-stability-test
#9
Damián Lobato-Márquez, Laura Molina-García, Inma Moreno-Córdoba, Francisco García-Del Portillo, Ramón Díaz-Orejas
Certain Salmonella enterica serovars belonging to subspecies I carry low-copy-number virulence plasmids of variable size (50-90 kb). All of these plasmids share the spv operon, which is important for systemic infection. Virulence plasmids are present at low copy numbers. Few copies reduce metabolic burden but suppose a risk of plasmid loss during bacterial division. This drawback is counterbalanced by maintenance modules that ensure plasmid stability, including partition systems and toxin-antitoxin (TA) loci...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27790927/an-investigation-of-the-mutagenic-activity-of-salamide-a-major-impurity-of-hydrochlorothiazide
#10
Esra Emerce, Ismet Cok, Sibel Sari, Omur Bostanci
Hydrochlorothiazide is a widely used antihypertensive agent and one of its major impurities, salamide (4-amino-6-chlorobenzene-1,3-disulphonamide), has a chemical structure containing a primary amino group, a functional group that has previously been reported to be associated with carcinogenic activity. It is known that hydrochlorothiazide purity is a challenging problem for the pharmaceutical industry. As there were no prior mutagenicity data for the impurity salamide, the aim was to investigate its mutagenicity in this study...
October 28, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27766229/evaluation-of-betulin-mutagenicity-by-salmonella-microsome-test
#11
Edson Hideaki Yoshida, Natália Tribuiani, Giovana Sabadim, Débora Antunes Neto Moreno, Eliana Aparecida Varanda, Yoko Oshima-Franco
Purpose: Betulin is a pentacyclic triterpene found in the outer barks of innumerous plants. This secondary metabolite is easily isolated from plants with the major interest in converting it to betulinic acid, which pharmacological properties were much more exploited than betulin. But, investments in the own betulin have been grown since no chemical step is necessary. In this study we focused the precursor betulin in order to evaluate its mutagenicity by Salmonella/microsome assay (Ames test). Methods: The Ames test was carried out using a commercial betulin exposed to Salmonella typhimurium strains TA98, TA100, TA102, and TA97a, in experiments with (+S9) and without (-S9) metabolic activation...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27764694/toxicity-and-genotoxicity-assessment-in-sediments-from-the-matanza-riachuelo-river-basin-argentina-under-the-influence-of-heavy-metals-and-organic-contaminants
#12
Lucía N Biruk, Juan Moretton, Alicia Fabrizio de Iorio, Cristian Weigandt, Jimena Etcheverry, Javier Filippetto, Anahí Magdaleno
The aim of this study was to investigate the parameters of chemical extraction associated with the detection of toxicity and genotoxicity in sediment sample extracts. Quantitative analysis of metals and polycyclic aromatic hydrocarbons (PAHs), together with a battery of four bioassays, was performed in order to evaluate the extraction efficiency of inorganic and organic toxicants. The extracts were carried out using two inorganic solvents, two organic solvents and two extraction methodologies, making a total of five extracts...
October 17, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27737816/safety-evaluation-of-styrax-liquidus-from-the-viewpoint-of-genotoxicity-and-mutagenicity
#13
Mohammad Charehsaz, Rengin Reis, Sinem Helvacioglu, Hande Sipahi, Etil Guzelmeric, Ebru Turkoz Acar, Gamze Cicek, Erdem Yesilada, Ahmet Aydin
ETHNOPHARMACOLOGICAL RELEVANCE: Styrax liquidus is a resinous exudate (balsam) obtained from the wounded trunk of the Liquidambar orientalis Mill. (Hamamelidaceae). Styrax has been used for treatment of various ailments in Turkish folk medicine such as skin problems, peptic ulcers, nocturnal enuresis, parasitic infections, antiseptic or as expectorant. AIM OF STUDY: In spite of frequent use of styrax in Turkish folk medicine as well as once as a stabilizer in perfumery industry, negative reports have been noticed by the international authority for restriction its use based on some limited evidences from an in vitro study...
October 10, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27735784/anaerobic-formate-and-hydrogen-metabolism
#14
Constanze Pinske, R Gary Sawers
Numerous recent developments in the biochemistry, molecular biology, and physiology of formate and H2 metabolism and of the [NiFe]-hydrogenase (Hyd) cofactor biosynthetic machinery are highlighted. Formate export and import by the aquaporin-like pentameric formate channel FocA is governed by interaction with pyruvate formate-lyase, the enzyme that generates formate. Formate is disproportionated by the reversible formate hydrogenlyase (FHL) complex, which has been isolated, allowing biochemical dissection of evolutionary parallels with complex I of the respiratory chain...
October 2016: EcoSal Plus
https://www.readbyqxmd.com/read/27726002/photorhabdus-asymbiotica-as-an-insect-and-human-pathogen
#15
Alexia Hapeshi, Nick R Waterfield
Photorhabdus asymbiotica is a species of bacterium that is pathogenic to humans whilst retaining the ability to infect insect hosts. Currently, there are two recognised subspecies, P. asymbiotica subsp. asymbiotica and P. asymbiotica subsp. australis with strains isolated from various locations in the USA, Australia, Thailand, Nepal and Europe. Like other species of Photorhabdus, P. asymbiotica subsp. australis was shown to form a symbiotic relationship with a Heterorhabditis nematode. In contrast to most strains of Photorhabdus luminescens, P...
September 14, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27713728/cell-free-spent-media-obtained-from-bifidobacterium-bifidum-and-bifidobacterium-crudilactis-grown-in-media-supplemented-with-3-sialyllactose-modulate-virulence-gene-expression-in-escherichia-coli-o157-h7-and-salmonella-typhimurium
#16
Pauline Bondue, Sébastien Crèvecoeur, François Brose, Georges Daube, Marie-Christine Seghaye, Mansel W Griffiths, Gisèle LaPointe, Véronique Delcenserie
Complex oligosaccharides from human milk (HMO) possess an antimicrobial activity and can promote the growth of bifidobacteria such as Bifidobacterium bifidum and Bifidobacterium longum subsp. infantis. In addition, fermentation of carbohydrates by bifidobacteria can result in the production of metabolites presenting an antivirulence effect on several pathogenic bacteria. Whey is rich in complex bovine milk oligosaccharides (BMO) structurally similar to HMO and B. crudilactis, a species of bovine origin, is able to metabolize some of those complex carbohydrates...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27694229/phosphinothricin-acetyltransferases-identified-using-in-vivo-in-vitro-and-bioinformatic-analyses
#17
Chelsey M VanDrisse, Kristy L Hentchel, Jorge C Escalante-Semerena
Acetylation of small molecules is widespread in nature, and in some cases, cells use this process to detoxify harmful chemicals. Streptomyces species utilize a Gcn5 N-acetyltransferase (GNAT), known as Bar, to acetylate and detoxify a self-produced toxin, phosphinothricin (PPT), a glutamate analogue. Bar homologues, such as MddA from Salmonella enterica, acetylate methionine analogues such as methionine sulfoximine (MSX) and methionine sulfone (MSO), but not PPT, even though Bar homologues are annotated as PPT acetyltransferases...
December 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27632361/impact-of-gluten-friendly-bread-on-the-metabolism-and-function-of-in-vitro-gut-microbiota-in-healthy-human-and-coeliac-subjects
#18
Antonio Bevilacqua, Adele Costabile, Triana Bergillos-Meca, Isidro Gonzalez, Loretta Landriscina, Emanuela Ciuffreda, Paola D'Agnello, Maria Rosaria Corbo, Milena Sinigaglia, Carmela Lamacchia
The main aim of this paper was to assess the in vitro response of healthy and coeliac human faecal microbiota to gluten-friendly bread (GFB). Thus, GFB and control bread (CB) were fermented with faecal microbiota in pH-controlled batch cultures. The effects on the major groups of microbiota were monitored over 48 h incubations by fluorescence in situ hybridisation. Short-chain fatty acids (SCFAs) were measured by high-performance liquid chromatography (HPLC). Furthermore, the death kinetics of Lactobacillus acidophilus, Bifidobacterium animalis subsp...
2016: PloS One
https://www.readbyqxmd.com/read/27628961/short-chain-nitrocompounds-as-a-treatment-of-layer-hen-manure-and-litter-effects-on-in-vitro-survivability-of-salmonella-generic-e-coli-and-nitrogen-metabolism
#19
Oscar Ruiz-Barrera, Robin C Anderson, Michael E Hume, Jonatan Corrales-Millan, Yamicela Castillo-Castillo, Agustin Corral-Luna, Jose Luis Guevara-Valdez, Jaime Salinas-Chavira, Carlos Rodriguez-Muela, Claudio Arzola-Alvarez
The current study was conducted to assess the bactericidal effectiveness of several nitrocompounds against pathogens in layer hen manure and litter. Evidence from an initial study indicated that treatment of layer hen manure with 12 mM nitroethane decreased populations of generic E. coli and total coliforms by 0.7 and 2.2 log10 colony forming units (CFU) g(-1), respectively, after 24 h aerobic incubation at ambient temperature when compared to untreated populations. Salmonella concentrations were unaffected by nitroethane in this study...
September 14, 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/27628932/fine-tuning-of-amino-sugar-homeostasis-by-eiia-ntr-in-salmonella-typhimurium
#20
Woongjae Yoo, Hyunjin Yoon, Yeong-Jae Seok, Chang-Ro Lee, Hyung Ho Lee, Sangryeol Ryu
The nitrogen-metabolic phosphotransferase system, PTS(Ntr), consists of the enzymes I(Ntr), NPr and IIA(Ntr) that are encoded by ptsP, ptsO, and ptsN, respectively. Due to the proximity of ptsO and ptsN to rpoN, the PTS(Ntr) system has been postulated to be closely related with nitrogen metabolism. To define the correlation between PTS(Ntr) and nitrogen metabolism, we performed ligand fishing with EIIA(Ntr) as a bait and revealed that D-glucosamine-6-phosphate synthase (GlmS) directly interacted with EIIA(Ntr)...
2016: Scientific Reports
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