keyword
https://read.qxmd.com/read/38411871/liver-imaging-and-pregnancy-what-to-expect-when-your-patient-is-expecting
#21
REVIEW
Giorgia Porrello, Roberto Cannella, Jacques Bernuau, Antoine Agman, Giuseppe Brancatelli, Marco Dioguardi Burgio, Valérie Vilgrain
Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver diseases that are more frequent during or exacerbated by pregnancy: acute herpes simplex hepatitis, Budd-Chiari syndrome, hemorrhagic hereditary telangiectasia, hepatocellular adenoma, portal vein thrombosis, and cholelithiasis; (3) coincidental conditions, including acute hepatitis, incidental focal liver lesions, metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatocellular carcinoma, liver abscesses and parasitosis, and liver transplantation...
February 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38405357/-nr1h4-mutation-and-rapid-progressive-intrahepatic-cholestasis-in-infancy-a-case-report-and-literature-review
#22
Chiao-Yu Yang, Hung-Wen Tsai, Yen-Yin Chou, Yao-Jong Yang
Farnesoid X receptor (FXR) is a nuclear bile acid receptor encoded by the NR1H4 gene, a vital regulator of bile acid homeostasis. Pathogenic mutations of NR1H4 manifest as low gamma-glutamyl transferase (GGT) cholestasis with rapid progression to liver failure, which is referred to as progressive familial intrahepatic cholestasis 5 (PFIC-5). Herein, we present a case with rapid progressive cholestasis, liver failure in early infancy with the NR1H4 termination mutation.
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38403070/gradual-dosing-of-ursodeoxycholic-acid-in-mothers-with-intrahepatic-cholestasis-of-pregnancy-may-improve-composite-neonatal-outcome
#23
JOURNAL ARTICLE
Amir Hamud, Matan J Cohen, Drorith Hochner-Celnikier, Benjamin Bar-Oz, Zvi Ackerman
INTRODUCTION AND OBJECTIVES: Intrahepatic cholestasis of pregnancy (ICP) is often accompanied by fetal and maternal complications. MATERIALS AND METHODS: Retrospective review of the clinical course of women with ICP and their neonates treated at our medical center over a 10-year period. Special attention was paid to the maternal and neonatal response to 2 different modes of ursodeoxycholic acid (UDCA) administration. RESULTS: Neonates of mothers with high total bile acid levels had a poorer composite neonatal outcome...
February 23, 2024: Annals of Hepatology
https://read.qxmd.com/read/38389228/-guidelines-for-clinical-diagnosis-treatment-and-management-of-intrahepatic-cholestasis-of-pregnancy-2024
#24
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2024: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/38385789/serum-transaminase-monitoring-and-successful-treatment-of-adhd-with-dextroamphetamine-in-a-patient-with-progressive-familial-intrahepatic-cholestasis-type-3-a-case-report-and-literature-review
#25
JOURNAL ARTICLE
Geoffrey Russel, Benjamin DeLucia
No abstract text is available yet for this article.
February 16, 2024: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/38384504/a-study-on-the-relationship-between-gut-microbiota-and-intrahepatic-cholestasis-of-pregnancy
#26
JOURNAL ARTICLE
Li-Wen Liu, Yan Chen, Liu-Jing Zhu, Qun-Xiang Xu, Shaolin Xu, Yanling Ding, Biao Yin
OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with a high incidence of complications in the mid and late stages of gestation. This study investigates differences in the composition of intestinal flora among pregnant women diagnosed with ICP, employing Illumina MiSeq high-throughput sequencing technology. METHODS: This case-control study obtained patient data from the hospital information system (HIS) and the laboratory information system (LIS)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38383222/acute-sickle-cell-hepatopathy-a-case-report-and-literature-review
#27
REVIEW
Morteza Hassanzadeh, Zahra Momayez Sanat, Somayeh Khayatian, Mohammadjavad Sotoudeheian, Amirmasoud Shahbazian, SeyedAhmad Hoseini
Sickle cell disease (SCD) is an inherited hemoglobinopathy with protean clinical manifestations. The liver could be affected by various SCD-associated complications of an overlapping nature. The clinical presentations of "sickle cell hepatopathy" range from clinically asymptomatic patients to those with life-threatening complications. Herein we report an SCD patient who presented with right upper quadrant abdominal pain and jaundice, eventually diagnosed as a self-limited form of acute sickle cell hepatopathy with overlapping features of acute hepatic crisis and benign intrahepatic cholestasis...
April 2024: Journal of the National Medical Association
https://read.qxmd.com/read/38379768/intrahepatic-cholestasis-of-pregnancy
#28
REVIEW
Rebecca Roediger, Jaquelyn Fleckenstein
No abstract text is available yet for this article.
2024: Clinical Liver Disease
https://read.qxmd.com/read/38375845/newly-described-mutations-of-the-unc45a-gene-in-infants-with-jaundice-and-pruritus
#29
Anna Degtyareva, Alina Dokshukina, Elena Filippova, Jekaterina Shubina, Ekaterina Tolmacheva, Igor Sadelov, Marina Albegova, Dmitriy Degtyarev
BACKGROUND: Cholestatic liver disease is an important cause of morbidity and mortality and a leading indication for liver transplantation in children. These include diseases, such as biliary atresia, Alagille syndrome, progressive familial intrahepatic cholestasis, sclerosing cholangitis, bile acid synthesis defects, and many others. CASE PRESENTATION: NGS was used as a diagnostic tool to identify the genetic cause in the patient with cholestatic syndrome and to figure out and describe what mutation will be found...
February 16, 2024: Current Pediatric Reviews
https://read.qxmd.com/read/38374662/hepatic-artery-vasospasm-masquerading-as-early-hepatic-artery-thrombosis-in-progressive-familial-intrahepatic-cholestasis-3-a-case-report
#30
Divij Jayant, Swapnesh Sahu, Basil Babu, Cherring Tandup, Arunanshu Behera
Post-liver transplant (LT) hepatic artery vasospasm is a vascular complication that is not well recognized and its incidence is not known. As a possible sequela to vasospasm, hepatic artery thrombosis is the second major cause of allograft failure after primary nonfunction and its reported incidence is 2.9% in adults and 8.3% in pediatric LT. Lacuna in knowledge regarding early hepatic artery vasospasm post-LT makes it a difficult condition to diagnose and treat, as the initial ischemic insult on graft can have devastating consequences...
February 20, 2024: Korean journal of transplantation
https://read.qxmd.com/read/38374571/update-on-the-diagnosis-and-management-of-neonatal-intrahepatic-cholestasis-caused-by-citrin-deficiency-expert-review-on-behalf-of-the-asian-pan-pacific-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#31
REVIEW
Ayano Inui, Jae Sung Ko, Voranush Chongsrisawat, Anupam Sibal, Winita Hardikar, Mei-Hwei Chang, Suporn Treepongkaruna, Katsuhiro Arai, Kyung Mo Kim, Huey-Ling Chen
Citrin deficiency is an autosomal recessive metabolic liver disease caused by mutations in the SLC25A13 gene. The disease typically presents with cholestasis, elevated liver enzymes, hyperammonemia, hypercitrullinemia, and fatty liver in young infants, resulting in a phenotype known as "neonatal intrahepatic cholestasis caused by citrin deficiency" (NICCD). The diagnosis relies on clinical manifestation, biochemical evidence of hypercitrullinemia, and identifying mutations in the SLC25A13 gene. Several common mutations have been found in patients of East Asian background...
February 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38374565/clinical-outcomes-of-abcb4-heterozygosity-in-infants-and-children-with-cholestatic-liver-disease
#32
JOURNAL ARTICLE
Robert Hegarty, Olivia Gurra, Jenneh Tarawally, Sammi Allouni, Obydur Rahman, Sandra Strautnieks, Eirini Kyrana, Nedim Hadzic, Richard J Thompson, Tassos Grammatikopoulos
OBJECTIVES: Biallelic variants in the adenosine triphosphate binding cassette subfamily B member 4 (ABCB4) gene which encodes the multidrug resistance 3 protein (MDR3) leads to progressive familiar intrahepatic cholestasis type 3. However, monoallelic variants are increasingly recognized as contributing to liver disease in adults. Our aim was to describe the clinical characteristics of MDR3 heterozygous variants in a large cohort of infants and children with cholestatic liver disease...
February 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38367126/current-understanding-of-essential-trace-elements-in-intrahepatic-cholestasis-of-pregnancy
#33
JOURNAL ARTICLE
Dan Shan, Qian Chen, Yupei Xie, Siyu Dai, Yayi Hu
Trace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma...
February 17, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/38366839/the-phospholipid-flippase-atp8b1-is-involved-in-the-pathogenesis-of-ulcerative-colitis-via-establishment-of-intestinal-barrier-function
#34
JOURNAL ARTICLE
Pim J Koelink, Valentina E Gómez-Mellado, Suzanne Duijst, Manon van Roest, Sander Meisner, Kam S Ho-Mok, Sabrina Frank, Babette S Appelman, Lysbeth Ten Bloemendaal, Georg F Vogel, Stan F J van de Graaf, Piter J Bosma, Ronald P J Oude Elferink, Manon E Wildenberg, Coen C Paulusma
OBJECTIVE: Patients with mutations in ATP8B1 develop Progressive Familial Intrahepatic Cholestasis type 1 (PFIC1), a severe liver disease that requires life-saving liver transplantation. PFIC1 patients also present with gastrointestinal problems, including intestinal inflammation and diarrhea, which are aggravated after liver transplantation. Here we investigate the intestinal function of ATP8B1 in relation to inflammatory bowel diseases. DESIGN: ATP8B1 expression was investigated in intestinal samples of patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) as well as in murine models of intestinal inflammation...
February 16, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38366352/thiopurine-metabolite-shunting-in-late-pregnancy-increases-the-risk-of-intrahepatic-cholestasis-of-pregnancy-in-women-with-inflammatory-bowel-disease-and-can-be-managed-with-split-dosing
#35
JOURNAL ARTICLE
Ralley Prentice, Emma Flanagan, Emily Wright, Lani Prideaux, William Connell, Miles Sparrow, Peter De Cruz, Mark Lust, Winita Hardikar, Rimma Goldberg, Sara Vogrin, Kirsten Palmer, Alyson Ross, Megan Burns, Tessa Greeve, Sally Bell
BACKGROUND AND AIMS: The risk of intrahepatic cholestasis of pregnancy (ICP) is increased in thiopurine exposed pregnancies. Thiopurine 'shunting', with a 6-methylmecrcaptopurine (MMP) to 6-thioguanine (TGN) ratio of >11, progresses over pregnancy, and may promote ICP development. We aimed to explore the association between thiopurine exposure and ICP, including the hypothesized impact of thiopurine shunting, and identify risk minimization strategies. METHODS: This prospective multi-centre cohort study compared thiopurine and biologic monotherapy exposed pregnant participants...
February 15, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38361799/global-incidence-of-intrahepatic-cholestasis-of-pregnancy-a-protocol-for-systematic-review-and-meta-analysis
#36
JOURNAL ARTICLE
Alireza Sadeghi
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) typically develops in the late second and third trimesters and resolves rapidly after delivery. Although not associated with serious maternal sequelae, ICP can be highly bothersome. On the other hand, the major complications of ICP are fetal and neonatal, which can be fatal. The current knowledge lacks an estimation regarding the global prevalence of ICP. METHODS: PubMed, Scopus, and Web of Science will be searched systematically...
February 2024: Health Science Reports
https://read.qxmd.com/read/38361148/exosomes-from-intrahepatic-cholestasis-of-pregnancy-induce-cell-apoptosis-through-the-mirna-6891-5p-ywhae-pathway
#37
JOURNAL ARTICLE
Ningzhen Ye, Xinrui Shi, Jianyi Gao, Ruirui Dong, Gaoying Wang, Jing Wang, Liang Luo, Ting Zhang
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse pregnancy outcomes; however, the underlying mechanisms are not fully understood. AIMS: This study aimed to determine the role of exosomal miR-6891-5p in placental trophoblast dysfunction in ICP and identify new biomarkers for ICP diagnosis. METHODS: Serum samples were collected from ICP patients and healthy pregnant women, and serum exosomes were extracted and identified...
February 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38355761/the-association-between-aspartate-aminotransferase-ast-to-platelets-plt-ratio-apri-and-the-development-of-intrahepatic-cholestasis-in-pregnancy-and-other-related-complications
#38
JOURNAL ARTICLE
Razan Saadi, Alla Saban, Adi Y Weintraub, David Yardeni, Tamar Eshkoli
OBJECTIVE: To assess the association between aspartate aminotransferase (AST) to platelet count ratio index (APRI score), during the first and third trimesters of pregnancy and the development of intrahepatic cholestasis in pregnancy (ICP). METHODS: Case-control study was conducted. The study included patients diagnosed with ICP by elevated bile acids (n = 118) and a control group of women with symptoms such as elevated liver enzymes or pruritus with normal level of bile acids (n = 127) who attended a large tertiary teaching medical center between the years 2014 and 2021...
February 15, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38353595/simultaneous-total-internal-biliary-diversion-during-liver-transplantation-for-progressive-familial-intrahepatic-cholestasis-type-1-standard-of-care
#39
JOURNAL ARTICLE
Jagadeesh Menon, Naresh Shanmugam, Mukul Vij, Fadl H Veerankutty, Ashwin Rammohan, Mohamed Rela
BACKGROUND: Post liver transplant (LT) patients with Progressive Familial Intrahepatic Cholestasis Type 1 (PFIC-1) often develop progressive graft steatohepatitis, intractable diarrhea & growth failure. A total internal biliary diversion (TIBD) during a LT may prevent or reverse these adverse events. METHODS: Children with PFIC- 1 who underwent a LT at our institute were divided into two groups, A & B based on the timeline where we started offering a TIBD in association with LT...
February 15, 2024: Liver Transplantation
https://read.qxmd.com/read/38346375/the-role-of-erp29-fos-emt-pathway-in-excessive-apoptosis-of-placental-trophoblast-cells-in-intrahepatic-cholestasis-of-pregnancy
#40
JOURNAL ARTICLE
Gaoying Wang, Ruirui Dong, Haijian Zhao, Ningzhen Ye, Jing Wang, Jing Cheng, Xinrui Shi, Liang Luo, Ting Zhang
BACKGROUND: Abnormal bile acid metabolism leading to changes in placental function during pregnancy. To determine whether endoplasmic reticulum protein 29 (ERp29) can mediate the pregnancy effects of cholestasis by altering the level of trophoblast cell apoptosis. METHODS: ERp29 in serum of 66 intrahepatic cholestasis of pregnancy (ICP) pregnant women and 74 healthy were detected by ELISA. Subcutaneous injection of ethinyl estradiol (E2) was used to induce ICP in pregnant rats...
February 8, 2024: Placenta
keyword
keyword
36057
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.